General Information of This Target (ID: PATR0CXRBX)
Target Name
Microtubule (MT)
Function
Microtubules are polymers of tubulin that form part of the cytoskeleton and provide structure and shape to eukaryotic cells. Microtubules play an important role in a number of cellular processes. They are involved in maintaining the structure of the cell and, together with microfilaments and intermediate filaments, they form the cytoskeleton. They also make up the internal structure of cilia and flagella. They provide platforms for intracellular transport and are involved in a variety of cellular processes, including the movement of secretory vesicles, organelles, and intracellular macromolecular assemblies.

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Full List of The ADC Related to This Target
Approved in 2019
Click To Hide/Show 10 ADC Related to This Stage
ADC Name Antibody Antigen Payload Linker ADC Info
Polatuzumab vedotin [4]
Polatuzumab
B-cell antigen receptor complex-associated protein beta chain (CD79B)
Monomethyl auristatin E
Mc-Val-Cit-PABC
Brentuximab vedotin
Brentuximab
Tumor necrosis factor receptor superfamily member 8 (TNFRSF8)
Monomethyl auristatin E
Mc-Val-Cit-PABC
Telisotuzumab vedotin
Telisotuzumab
Hepatocyte growth factor receptor (MET)
Monomethyl auristatin E
Mc-Val-Cit-PABC
Trastuzumab emtansine [5]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
DM1
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
Disitamab vedotin
Hertuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
Mc-Val-Cit-PABC
Tisotumab vedotin [6]
Tisotumab
Tissue factor (F3)
Monomethyl auristatin E
Mc-Val-Cit-PABC
Mirvetuximab soravtansine [7]
Mirvetuximab
Folate receptor alpha (FOLR1)
DM4
Sulfo-SPDB
Enfortumab vedotin [8]
Enfortumab
Nectin-4 (NECTIN4)
Monomethyl auristatin E
Mc-Val-Cit-PABC
Belantamab mafodotin [9]
Belantamab
Tumor necrosis factor receptor superfamily member 17 (TNFRSF17)
Monomethyl auristatin F
Maleimido-caproyl
Becotatug vedotin
Becotatug
Epidermal growth factor receptor (EGFR)
Monomethyl auristatin E
Mc-Val-Cit-PABC
Phase 3
Click To Hide/Show 8 ADC Related to This Stage
ADC Name Antibody Antigen Payload Linker ADC Info
Trastuzumab envedotin
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
NH2-PEG3-Val-Cit-PABC
Tusamitamab ravtansine
Tusamitamab
Carcinoembryonic antigen-related cell adhesion molecule 5 (CEACAM5)
DM4
N-succinimidyl 4-(2-pyridyldithio) butanoate (SPDB)
Upifitamab rilsodotin
Upifitamab
Sodium-dependent phosphate transport protein 2B (SLC34A2)
AF-HPA
Dolaflexin polymer
Tecotabart vedotin
Tecotabart
Claudin-18.2 (CLDN18.2)
Monomethyl auristatin E
Mc-Val-Cit-PABC
Sonesitatug vedotin
Sonesitatug
Claudin-18.2 (CLDN18.2)
Monomethyl auristatin E
Mc-Val-Cit-PABC
Fetrastobart vedotin
Anti-PD-L1 SGN-PDL1V mAb
Programmed cell death 1 ligand 1 (PD-L1)
Monomethyl auristatin E
Mc-Val-Cit-PABC
Sigvotatug vedotin
Sigvotatug
Integrin beta-6 (ITGB6)
Monomethyl auristatin E
Mc-Val-Cit-PABC
Recombinant anti-HER2 humanized mAb-DM1
Undisclosed
Receptor tyrosine-protein kinase erbB-2 (HER2)
Mertansine DM1
Undisclosed
Phase 3 (discontinued)
Click To Hide/Show 2 ADC Related to This Stage
ADC Name Antibody Antigen Payload Linker ADC Info
TAA-013
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Mertansine DM1
Succinimidyl-4- (N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
BAT8001
BAT0606
Receptor tyrosine-protein kinase erbB-2 (HER2)
Batansine
Maleimido-caproyl
Phase 2/3 (discontinued)
Click To Hide/Show 1 ADC Related to This Stage
ADC Name Antibody Antigen Payload Linker ADC Info
Luveltamab tazevibulin
Luveltamab
Folate receptor alpha (FOLR1)
SC209
DBCO-Val-Cit-PABA
Phase 2 (discontinued)
Click To Hide/Show 11 ADC Related to This Stage
ADC Name Antibody Antigen Payload Linker ADC Info
Praluzatamab ravtansine
Praluzatamab
CD166 antigen (ALCAM)
DM4
N-succinimidyl 4-(2-pyridyldithio) butanoate (SPDB)
BB-1701
Anti-HER2 antibody
Receptor tyrosine-protein kinase erbB-2 (HER2)
Eribulin
Mal-PEG2-Val-Cit-PABC
Ozuriftamab vedotin
Ozuriftamab
Tyrosine-protein kinase transmembrane receptor ROR2 (ROR2)
Monomethyl auristatin E
Mc-Val-Cit-PABC
Ladiratuzumab vedotin
Ladiratuzumab
Zinc transporter ZIP6 (SLC39A6)
Monomethyl auristatin E
Mc-Val-Cit-PABC
Anvatabart opadotin
Anvatabart
Receptor tyrosine-protein kinase erbB-2 (HER2)
Amberstatin 269 (AS269)
Hydroxylamine-PEG4
Zilovertamab vedotin
Zilovertamab
Inactive tyrosine-protein kinase transmembrane receptor ROR1 (ROR1)
Monomethyl auristatin E
Mc-Val-Cit-PABC
RC108
Anti-c-Met antibody
Hepatocyte growth factor receptor (MET)
Monomethyl auristatin E
Mc-Val-Cit-PABC
DX126-262
DX-CHO9
Receptor tyrosine-protein kinase erbB-2 (HER2)
Tub114
Mal-PEG10 based linker
FOR46
YS5
Membrane cofactor protein (CD46)
Monomethyl auristatin E
A cleavable linker
MRG001
Chimeric anti-CD20 mAb
B-lymphocyte antigen CD20 (MS4A1)
Monomethyl auristatin E
Mc-Val-Cit-PABC
SHR-4602
Pertuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
ER300
Stable enzyme-cleavable linker
Phase 2 (discontinued)
Click To Hide/Show 11 ADC Related to This Stage
ADC Name Antibody Antigen Payload Linker ADC Info
AGS-16C3F
Anti-ENPP3 AGS-16C3F mAb
Ectonucleotide pyrophosphatase/phosphodiesterase family member 3 (ENPP3)
Monomethyl auristatin F
Maleimido-caproyl
Naratuximab emtansine
Naratuximab
Leukocyte antigen CD37 (CD37)
DM1
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
Lifastuzumab vedotin
Lifastuzumab
Sodium-dependent phosphate transport protein 2B (SLC34A2)
Monomethyl auristatin E
Mc-Val-Cit-PABC
Anetumab ravtansine
Anetumab
Mesothelin (MSLN)
DM4
N-succinimidyl 4-(2-pyridyldithio) butanoate (SPDB)
Indusatumab vedotin
Indusatumab
GC-C
Monomethyl auristatin E
Mc-Val-Cit-PABC
Lorvotuzumab mertansine
Lorvotuzumab
Neural cell adhesion molecule 1 (NCAM1)
DM1
N-succinimidyl 4-(2-pyridyldithio) pentanoate (SPP)
Coltuximab ravtansine
Coltuximab
B-lymphocyte antigen CD19 (CD19)
DM4
N-succinimidyl 4-(2-pyridyldithio) butanoate (SPDB)
Glembatumumab vedotin
Glembatumumab
Transmembrane glycoprotein NMB (GPNMB)
Monomethyl auristatin E
Mc-Val-Cit-PABC
Cantuzumab ravtansine
Cantuzumab
Mucin-1 (MUC1)
DM4
N-succinimidyl 4-(2-pyridyldithio) butanoate (SPDB)
PSMA ADC
Fully human anti-PSMA IgG1 mAb
Glutamate carboxypeptidase 2 (FOLH1)
Monomethyl auristatin E
Mc-Val-Cit-PABC
SAR566658
huDS6
Carbonic anhydrase 6 (CA6)
DM4
N-succinimidyl 4-(2-pyridyldithio) butanoate (SPDB)
Phase 1/2
Click To Hide/Show 17 ADC Related to This Stage
ADC Name Antibody Antigen Payload Linker ADC Info
PEN-221
Undisclosed
Somatostatin receptor type 2 (SSTR2)
Mertansine DM1
Disulfide cleavable linker
Mecbotamab vedotin
Mecbotamab
Tyrosine-protein kinase receptor UFO (AXL)
Monomethyl auristatin E
Mc-Val-Cit-PABC
CX-2029
Anti-CD71 CX-151 probody
Transferrin receptor protein 1 (TFRC)
Monomethyl auristatin E
Mc-Val-Cit-PABC
Farletuzumab ecteribulin
Farletuzumab
Folate receptor alpha (FOLR1)
Eribulin
Mal-PEG2-Val-Cit-PABC
Bulumtatug fuvedotin
Bulumtatug
Nectin-4 (NECTIN4)
Monomethyl auristatin E
IDM-Val-Cit-PBCA
BB-1705
Anti-EGFR antibody
Epidermal growth factor receptor (EGFR)
Eribulin
Mal-PEG2-Val-Cit-PABC
BIO-106
Anti-TROP2 antibody
Tumor-associated calcium signal transducer 2 (TACSTD2)
TAMTM
A non-cleavable linker
Vemzatatug vedotin
Anti-GPRC5D antibody
G-protein coupled receptor family C group 5 member D (GPRC5D)
Monomethyl auristatin E
Mc-Val-Cit-PABC
MRG-004A
Undisclosed
Tissue factor (F3)
Monomethyl auristatin E
Valine-Citrulline (BCN-valyl-citrulline; Protease-cleavable linker)
Ciletatug vedotin
Ciletatug
Claudin-18.2 (CLDN18.2)
Monomethyl auristatin E
Mc-Val-Cit-PABC
Misitatug blivedotin
Misitatug
Mesothelin (MSLN)
Monomethyl auristatin E
PY-MAA-Val-Cit-PABC
REGN5093-M114
REGN5093
Hepatocyte growth factor receptor (MET)
Maytansine derivative M24
SC-Val-Cit-PABC
SYS6002
Anti-Nectin-4 antibody
Nectin-4 (NECTIN4)
Monomethyl auristatin E
NH2-PEG3-Val-Cit-PABC
JK06
Anti-5T4 antibody
Trophoblast glycoprotein (TPBG)
Monomethyl auristatin E
Mc-Val-Cit-PABC
ILB-3101
Anti-B7H3 antibody
CD276 antigen (CD276)
Eribulin
A cleavable linker
LCB84
Hu2G10
Tumor-associated calcium signal transducer 2 (TACSTD2)
Monomethyl auristatin E
β-glucuronide linker
PRO1107
Anti-PTK7 antibody
Inactive tyrosine-protein kinase 7 (PTK7)
Monomethyl auristatin E
A cleavable linker
Phase 1/2 (discontinued)
Click To Hide/Show 10 ADC Related to This Stage
ADC Name Antibody Antigen Payload Linker ADC Info
OBI-999
OBI-888
Globo H (globotriaosylceramide)
Monomethyl auristatin E
ThioBridge-PEG24-Val-Cit-PABC
Bezetabart debotansine
Bezetabart
HLA class II histocompatibility antigen gamma chain (CD74)
SC347
Cys-12 ADC linker
Enapotamab vedotin
Enapotamab
Tyrosine-protein kinase receptor UFO (AXL)
Monomethyl auristatin E
Mc-Val-Cit-PABC
Depatuxizumab mafodotin
Depatuxizumab
Epidermal growth factor receptor (EGFR)
Monomethyl auristatin F
Maleimido-caproyl
BMS-986148
BMS-986021
Mesothelin (MSLN)
Tubulysin
Mc-Val-Cit
Lonigutamab ugodotin
Lonigutamab
Insulin-like growth factor 1 receptor (IGF1R)
F554443
Maleimido-caproyl
STI-6129
STI-5171
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 (CD38)
Duostatin 5.2
Non-polyethylene glycol linker
MEDI4276
MEDI-4276
Receptor tyrosine-protein kinase erbB-2 (HER2 ECD2); Receptor tyrosine-protein kinase erbB-2 (HER2 ECD4)
AZ13599185
Maleimido-caproyl based linker
MLN2704
MLN591
Glutamate carboxypeptidase 2 (FOLH1)
DM1
N-succinimidyl 4-(2-pyridyldithio) pentanoate (SPP)
BMS-986183
Anti-GPC3 antibody
Glypican-3 (GPC3)
Tubulysin
Val-Cit dipeptide linker
Phase 1 (discontinued)
Click To Hide/Show 41 ADC Related to This Stage
ADC Name Antibody Antigen Payload Linker ADC Info
Felmetatug vedotin
Felmetatug
V-set domain-containing T-cell activation inhibitor 1 (VTCN1)
Monomethyl auristatin E
Mc-Val-Cit-PABC
B-003
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Mertansine DM1
Succinimidyl-4- (N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
GQ1001
Trastuzumab variant
Receptor tyrosine-protein kinase erbB-2 (HER2)
DM1
K'-MCC'
AMT-151
Ab-151
Folate receptor alpha (FOLR1)
Duostatin 5
Pip-Val-Cit linker
AGX101
Anti-TM4SF1 antibody
Transmembrane 4 L6 family member 1 (TM4SF1)
Maytansine derivative
A non-cleavable linker
ARX-305
Humanized anti-CD70 mAb
CD70 antigen (CD70)
Monomethyl auristatin F
Oxime-PEG3
ASN004
Anti-5T4 scFv-Fc mAb
Trophoblast glycoprotein (TPBG)
AF-HPA
Fleximer polymer
ATG-022
Anti-CLDN18.2 antibody
Claudin-18.2 (CLDN18.2)
Monomethyl auristatin E
Mc-Val-Cit-PABC
BB-1709
Anti-CD73 antibody
Thymidylate 5'-phosphatase (NT5E)
Monomethyl auristatin E
Undisclosed
BC3195
Anti-CDH3 antibody
Cadherin-3 (CDH3)
Monomethyl auristatin E
Val-Cit dipeptide linker
DXC009
Humanized anti-BCMA mAb
Tumor necrosis factor receptor superfamily member 17 (TNFRSF17)
Undisclosed
Undisclosed
JS107
Anti-CLDN18.2 mAb
Claudin-18.2 (CLDN18.2)
Monomethyl auristatin E
Maleimide linker of vc PAB
M1231 [10]
An antibody scaffold targeting MUC1 and EGFR
Epidermal growth factor receptor (EGFR); Mucin-1 (MUC1)
SC209
DBCO-Val-Cit-PABA
MEN-1309
MBH-1309
Lymphocyte antigen 75 (LY75)
Mertansine DM4
N-succinimidyl 4- (2-pyridyldithio) butanoate (SPDB)
MYTX-011
Anti-c-MET pH-dependent mAb
Hepatocyte growth factor receptor (MET)
Monomethyl auristatin E
Mc-Val-Cit-PABC
NBT508
Anti-CD79b antibody
B-cell antigen receptor complex-associated protein beta chain (CD79B)
Monomethyl auristatin E
TetraM-Val-Cit-PABC
PR301
Anti-CLDN18.2 antibody
Claudin-18.2 (CLDN18.2)
Duostatin 5
A cleavable linker
Micvotabart pelidotin
Micvotabart
EDB-FN
Auristatin 0101 (Aur0101)
Mc-Val-Cit-PABC
KM501
Trastuzumab/Pertuzumab biparatopic bsAb
Receptor tyrosine-protein kinase erbB-2 (HER2 ECD2); Receptor tyrosine-protein kinase erbB-2 (HER2 ECD4)
Monomethyl auristatin E
Undisclosed
DXC005
Anti-Muc1 antibody
Mucin-1 (MUC1)
Tub201
Undisclosed
Ixotatug vedotin
Ixotatug
Claudin-6 (CLDN6)
Monomethyl auristatin E
Mc-Val-Cit-PABC
TRS005
Anti-CD20 antibody
B-lymphocyte antigen CD20 (MS4A1)
Monomethyl auristatin E
Mc-Val-Cit-PABC
Emiltatug ledadotin
Emiltatug
V-set domain-containing T-cell activation inhibitor 1 (VTCN1)
AF-HPA
A cleavable ester linker
EBC-129
Anti N256-glycosylated CEACAM5 and CEACAM6 antibody
Carcinoembryonic antigen-related cell adhesion molecule 5 (CEACAM5); Carcinoembryonic antigen-related cell adhesion molecule 6 (CEACAM6)
Monomethyl auristatin E
Mc-Val-Cit-PABC
BA1302
Anti-CD228 antibody
Melanotransferrin (MELTF)
Monomethyl auristatin E
MC-β-Ala-(glucuronide)-PABC
DXC-004A
Nimotuzumab derivative
Epidermal growth factor receptor (EGFR)
Tubulysin B analog
Undisclosed
XB010
Anti-5T4 antibody
Trophoblast glycoprotein (TPBG)
Monomethyl auristatin E
RED-601 linker
BRY-812
Undisclosed
Zinc transporter ZIP6 (SLC39A6)
Monomethyl auristatin E
Undisclosed
NN3201
NN2101
Mast/stem cell growth factor receptor Kit (KIT)
Monomethyl auristatin E
Bis-sulfone-(PEG24)-Glu-Val-Cit-PAB
SMP-656
Anti-HER2 antibody
Receptor tyrosine-protein kinase erbB-2 (HER2)
Eribulin
SuperHydraTM linker
ADRX-0706
Anti-Nectin-4 antibody
Nectin-4 (NECTIN4)
AP052
Adcentrx' proprietary linker
Opugotamig olatansine
Opugotamig
Folate receptor alpha (FOLR1)
DM21-C
Stable cleavable peptide linker
F0002-ADC
Brentuximab
Tumor necrosis factor receptor superfamily member 8 (TNFRSF8)
DM1
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
Zarutatug vedotin
Zarutatug
Cadherin-17 (CDH17)
Monomethyl auristatin E
Mc-Val-Cit-PABC
roltotatug vedotin
Roltotatug
Protein delta homolog 1 (DLK1)
Monomethyl auristatin E
Mc-Val-Cit-PABC
BL-B16D1
Anti-EGFR/HER3 bsAb
Epidermal growth factor receptor (EGFR); Receptor tyrosine-protein kinase erbB-3 (HER3)
WA-00
Undisclosed
DXC007
A recombinant anti-CD33 mAb
Myeloid cell surface antigen CD33 (CD33)
Tub255
Undisclosed
BL-M17D1
Anti-HER2 antibody
Receptor tyrosine-protein kinase erbB-2 (HER2)
WA-00
Undisclosed
LNCB74
Anti-B7-H4 IgG1k mAb
V-set domain-containing T-cell activation inhibitor 1 (VTCN1)
Monomethyl auristatin E
β-glucuronide linker
INA03
Anti-CD71 mAb
Transferrin receptor protein 1 (TFRC)
Monomethyl auristatin E
APN-PEG5-Val-Cit-PABC
SGN-35T
Brentuximab
Tumor necrosis factor receptor superfamily member 8 (TNFRSF8)
Monomethyl auristatin E
Mp-D-leucine-alanine-glutamate-PABC
Phase 1 (discontinued)
Click To Hide/Show 62 ADC Related to This Stage
ADC Name Antibody Antigen Payload Linker ADC Info
Samrotamab vedotin
Samrotamab
Leucine-rich repeat-containing protein 15 (LRRC15)
Monomethyl auristatin E
Mc-Val-Cit-PABC
Denintuzumab mafodotin
Denintuzumab
B-lymphocyte antigen CD19 (CD19)
Monomethyl auristatin F
Maleimido-caproyl
Cantuzumab mertansine
Cantuzumab
Mucin-1 (MUC1)
DM1
N-succinimidyl 4-(2-pyridyldithio) pentanoate (SPP)
ALT-P7
Trastuzumab variant
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
Val-Cit dipeptide linker
Zanidatamab zovodotin
Zanidatamab
Receptor tyrosine-protein kinase erbB-2 (HER2 ECD2); Receptor tyrosine-protein kinase erbB-2 (HER2 ECD4)
ZD02044
Mc-PEG3-Val-Cit
Pinatuzumab vedotin
Pinatuzumab
B-cell receptor CD22 (CD22)
Monomethyl auristatin E
Mc-Val-Cit-PABC
Vorsetuzumab mafodotin
Vorsetuzumab
CD70 antigen (CD70)
Monomethyl auristatin F
Maleimido-caproyl
Sofituzumab vedotin
Sofituzumab
Mucin-16 (MUC16)
Monomethyl auristatin E
Mc-Val-Cit-PABC
Azintuxizumab vedotin
Azintuxizumab
SLAM family member 7 (SLAMF7)
Monomethyl auristatin E
Mc-Val-Cit-PABC
AVE9633
HuMy9-6
Myeloid cell surface antigen CD33 (CD33)
DM4
N-succinimidyl 4-(2-pyridyldithio) butanoate (SPDB)
BIIB015
HuB3F6
Teratocarcinoma-derived growth factor 1 (TDGF1)
DM4
N-succinimidyl 4-(2-pyridyldithio) butanoate (SPDB)
PCA062
CQY684
Cadherin-3 (CDH3)
DM1
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
CDX-014
CR014
Hepatitis A virus cellular receptor 1 (HAVCR1)
Monomethyl auristatin E
Mc-Val-Cit-PABC
XMT-1592
Anti-NaPi-2b antibody
Sodium-dependent phosphate transport protein 2B (SLC34A2)
AF-HPA
Cys-13 ADC linker
AbGn-107
Anti-AbGn-7 antibody
AbGn-7 antigen
DM4
Val-Cit dipeptide linker
AGS67E
AGS67C
Leukocyte antigen CD37 (CD37)
Monomethyl auristatin E
Mc-Val-Cit-PABC
AMG 224
Anti-human BCMA IgG1 mAb
Tumor necrosis factor receptor superfamily member 17 (TNFRSF17)
DM1
4-[N-maleimidomethyl] cyclohexane-1-carboxylate (MCC)
PF-06804103
Trastuzumab-(κK183C+K290C)
Receptor tyrosine-protein kinase erbB-2 (HER2)
Auristatin 0101 (Aur0101)
Mc-Val-Cit-PABC
Aprutumab ixadotin
Aprutumab
Fibroblast growth factor receptor 2 (FGFR2)
Auristatin W
Caproyl acid
Cofetuzumab pelidotin
Cofetuzumab
Inactive tyrosine-protein kinase 7 (PTK7)
Auristatin 0101 (Aur0101)
Mc-Val-Cit-PABC
DAC-002
Anti-TROP2 antibody
Tumor-associated calcium signal transducer 2 (TACSTD2)
Tubulysin 196
2,3-disubstituted long side-chain hydrolysis-resistant linker
GB251
Anti-HER2 antibody
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
BiM-Val-Cit-PABC
Iladatuzumab vedotin
Iladatuzumab
B-cell antigen receptor complex-associated protein beta chain (CD79B)
Monomethyl auristatin E
Mc-Val-Cit-PABC
Ispectamab debotansine
Ispectamab
Tumor necrosis factor receptor superfamily member 17 (TNFRSF17)
SC347
Cys-12 ADC linker
JBH492
121G12
C-C chemokine receptor type 7 (CCR7)
DM4
A cleavable linker
Losatuxizumab vedotin
Losatuxizumab
Epidermal growth factor receptor (EGFR)
Monomethyl auristatin E
Mc-Val-Cit-PABC
Lupartumab amadotin
Lupartumab
Ly6/PLAUR domain-containing protein 3 (LYPD3)
Auristatin W derivative
Mc-hydrazide linker
RG7841
MLYE4489A
Lymphocyte antigen 6E (LY6E)
Monomethyl auristatin E
Mc-Val-Cit-PABC
SGN-ALPV
H12F3
Phospholipase A-2-activating protein; Alkaline phosphatase, germ cell type (ALPG)
Monomethyl auristatin E
Mc-Val-Cit-PABC
SGN-CD228A
HL49
Melanotransferrin (MELTF)
Monomethyl auristatin E
Mal PEG12 based β-glucuronide linker
SGN-CD48A
Anti-SLAMF2 mAb
CD48 antigen (CD48)
Monomethyl auristatin E
PEGylated β-glucuronide linker
SGN-STNV
Anti-Onco-foetal sialyl-Tn antibody
Onco-foetal sialyl-Tn
Monomethyl auristatin E
Mc-Val-Cit-PABC
SHR-A1201
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Mertansine DM1
Succinimidyl-4- (N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
SHR-A1403
Anti-c-MET IgG2 mAb
Hepatocyte growth factor receptor (MET)
SHR152852
L2-MC
Sirtratumab vedotin
Sirtratumab
SLIT and NTRK-like protein 6 (SLITRK6)
Monomethyl auristatin E
Mc-Val-Cit-PABC
SYSA1801
Anti-CLDN18.2 mAb
Claudin-18.2 (CLDN18.2)
Monomethyl auristatin E
PEG3-Val-Cit-PABC
TRPH-222
Anti-CD20 antibody
B-cell receptor CD22 (CD22)
DM1
HIPS-4AP
Samatatug zovodotin
Samatatug
Tissue factor (F3)
ZD02044
Mc-PEG3-Val-Cit
PF-06263507
PF-06281192
Trophoblast glycoprotein (TPBG)
Monomethyl auristatin F
Maleimido-caproyl
ASG-5ME
Anti-SLC44A4 IgG2 mAb
Choline transporter-like protein 4 (SLC44A4)
Monomethyl auristatin E
Mc-Val-Cit-PABC
AGS62P1
Anti-FLT3 IgG1κ mAb
Receptor-type tyrosine-protein kinase FLT3 (FLT3)
AGD-0182
Alkoxyamine linker
LOP628
LMJ729
Mast/stem cell growth factor receptor Kit (KIT)
DM1
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
BAT8003
Anti-TROP2 antibody
Tumor-associated calcium signal transducer 2 (TACSTD2)
Batansine
Maleimido-caproyl
BAY 79-4620
3ee9
Carbonic anhydrase 9 (CA9)
Monomethyl auristatin E
Val-Cit dipeptide linker
Bivatuzumab mertansine
Bivatuzumab
CD44 antigen (CD44)
DM1
N-succinimidyl 4-(2-pyridyldithio) pentanoate (SPP)
HKT288
Anti-CDH6 HKT-288 mAb
Cadherin-6 (CDH6)
DM4
Sulfo-SPDB
IMGN388
Intetumumab
Integrin alpha-V (ITGAV)
DM4
N-succinimidyl 4-(2-pyridyldithio) butanoate (SPDB)
Laprituximab emtansine
Laprituximab
Epidermal growth factor receptor (EGFR)
DM1
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
MEDI-547
Anti-EPHA2 (1C1) mAb
Ephrin type-A receptor 2 (EPHA2)
Monomethyl auristatin F
Maleimido-caproyl
PF-06650808
Hu28
Neurogenic locus notch homolog protein 3 (NOTCH3)
Auristatin 0101 (Aur0101)
Mc-Val-Cit-PABC
PF-06664178
PF-06478924
Tumor-associated calcium signal transducer 2 (TACSTD2)
Auristatin 0101 (Aur0101)
AcLys-Val-Cit-PABC
RG7598
MFRF3266A
Fc receptor-like protein 5 (FCRL5)
Monomethyl auristatin E
Mc-Val-Cit-PABC
RG7636
MEDN6000A
ETB
Monomethyl auristatin E
Mc-Val-Cit-PABC
RG7882
MMUC3333A
Mucin-16 (MUC16)
Monomethyl auristatin E
Mc-Val-Cit-PABC
Vandortuzumab vedotin
Vandortuzumab
Metalloreductase STEAP1 (STEAP1)
Monomethyl auristatin E
Mc-Val-Cit-PABC
XMT-1522
XMT-1519
Receptor tyrosine-protein kinase erbB-2 (HER2)
AF-HPA
Fleximer polymer
SAR428926
Anti-LAMP-1 antibody
Lysosome-associated membrane glycoprotein 1 (LAMP1)
DM4
N-succinimidyl 4-(2-pyridyldithio) butanoate (SPDB)
LY3076226
IMC-D11
Fibroblast growth factor receptor 3 (FGFR3)
DM4
Sulfo-SPDB
AMG 172
Anti-CD70 mAb
CD70 antigen (CD70)
DM1
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
RG7600 [11]
H7D9.v3
Mesothelin (MSLN)
Monomethyl auristatin E
Mc-Val-Cit-PABC
AMG 595
Anti-EGFRvIII mAb
Epidermal growth factor receptor variant III (EGFRvIII)
DM1
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
SGN-CD47M
Humanized anti-CD47 IgG1 mAb
Leukocyte surface antigen CD47 (CD47)
Monomethyl auristatin E
Metalloproteinases cleavable linker
Clinical candidate
Click To Hide/Show 1960 ADC Related to This Stage
ADC Name Antibody Antigen Payload Linker ADC Info
Cirmtuzumab vedotin [12]
Cirmtuzumab
Inactive tyrosine-protein kinase transmembrane receptor ROR1 (ROR1)
Monomethyl auristatin E
Lysine-linker
Mirvetuximab-SPP-DM1 [13]
Mirvetuximab
Folate receptor alpha (FOLR1)
Mertansine DM1
N-succinimidyl 4-(2-pyridyldithio) pentanoate (SPP)
Mirvetuximab-SPDB-DM4 [14]
Mirvetuximab
Folate receptor alpha (FOLR1)
Mertansine DM4
N-succinimidyl 4-(2-pyridyldithio) butanoate (SPDB)
Mirvetuximab-SMCC-DM1 [13]
Mirvetuximab
Folate receptor alpha (FOLR1)
Mertansine DM1
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
HuFR1-48-SMCC-DM1 [13]
Anti-FOLR1 huFR1-48
Folate receptor alpha (FOLR1)
Mertansine DM1
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
HuFR1-49-SMCC-DM1 [13]
Anti-FOLR1 huFR1-49
Folate receptor alpha (FOLR1)
Mertansine DM1
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
HuFR1-57-SMCC-DM1 [13]
Anti-FOLR1 huFR1-57
Folate receptor alpha (FOLR1)
Mertansine DM1
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
HuFR1-65-SMCC-DM1 [13]
Anti-FOLR1 huFR1-65
Folate receptor alpha (FOLR1)
Mertansine DM1
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
54E-Val-Cit-MMAE [15]
Anit-TF mAb 54E
Tissue factor (F3)
Monomethyl auristatin E
Mc-Val-Cit-PABC
43Ea-Val-Cit-MMAE [15]
Anit-TF mAb 43Ea
Tissue factor (F3)
Monomethyl auristatin E
Mc-Val-Cit-PABC
43D7-Val-Cit-MMAE [15]
Anit-TF mAb 43D7
Tissue factor (F3)
Monomethyl auristatin E
Mc-Val-Cit-PABC
43B1-Val-Cit-MMAE [15]
Anit-TF mAb 43B1
Tissue factor (F3)
Monomethyl auristatin E
Mc-Val-Cit-PABC
39A-Val-Cit-MMAE [15]
Anit-TF mAb 39A
Tissue factor (F3)
Monomethyl auristatin E
Mc-Val-Cit-PABC
29E-Val-Cit-MMAE [15]
Anit-TF mAb 29E
Tissue factor (F3)
Monomethyl auristatin E
Mc-Val-Cit-PABC
25G1-Val-Cit-MMAE [15]
Anit-TF mAb 25G1
Tissue factor (F3)
Monomethyl auristatin E
Mc-Val-Cit-PABC
25A3-Val-Cit-MMAE [15]
Anit-TF mAb 25A3
Tissue factor (F3)
Monomethyl auristatin E
Mc-Val-Cit-PABC
25A-Val-Cit-MMAE [15]
Anit-TF mAb 25A
Tissue factor (F3)
Monomethyl auristatin E
Mc-Val-Cit-PABC
RcEDB-ADC [16]
Reverse chimeric (rc) Anti-EDB-FN L19
Fibronectin (FN1)
Auristatin 0101
Mc-Val-Cit-PABC
PODO447-ADC [17]
PODO447
Podocalyxin (PODXL)
Monomethyl auristatin E
Mc-Val-Cit-PABC
Anti-PIEZO1-MMAE [18]
Anti-PIEZO1 mAb
Piezo-type mechanosensitive ion channel component 1 (PIEZO1)
Monomethyl auristatin E
Mc-Val-Cit-PABC
C12G1-DM1 [19]
Anti-NECTIN2 mAb c12G1
Nectin-2 (NECTIN2)
Mertansine DM1
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
HzMUC1-MMAE [20]
HzMUC1
Mucin-1 (MUC1)
Monomethyl auristatin E
Mc-Val-Cit-PABC
LSR-ADC [21]
Anti-LSR mAb
Lipolysis-stimulated lipoprotein receptor (LSR)
Monomethyl auristatin E
Mc-Val-Cit-PABC
LRG1-ADC 5 [22]
Magacizumab
Leucine-rich alpha-2-glycoprotein (LRG1)
Monomethyl auristatin E
Dipeptide-diBrPD (dibromopyridazinedione )
1131-MMAE [23]
C-1131
Kita-kyushu lung cancer antigen 1 (CT83)
Monomethyl auristatin E
Mc-Val-Cit-PABC
Trastuzumab-SYNtansine [24]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Ahx-maytansine
BCN-HydraSpace-Val-Cit-PABC
Tmab-SPP-DM1 [25]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Mertansine DM1
N-succinimidyl 4-(2-pyridyldithio) pentanoate (SPP)
Tmab-SSNPP-DM3 [25]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Maytansinoid DM3
Sulfosuccinimidyl-N-succinimidyl-4-(5-nitro-2-pyridyldithio) pentanoate (SSNPP)
Tmab-SSNPP-DM4 [25]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Mertansine DM4
Sulfosuccinimidyl-N-succinimidyl-4-(5-nitro-2-pyridyldithio) pentanoate (SSNPP)
Trastuzumab-AJICAP-maytansinoid [26]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Mertansine DM1
AJICAP
Mil40-12B [27]
Mil40
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
Maleamic methyl ester-based linker 12B
ADAPT6-ABD-mcDM1 [28]
ADAPT6-ABD
Receptor tyrosine-protein kinase erbB-2 (HER2)
Mertansine DM1
Maleimidocaproyl (Ser3-Gly)3
HA15-1C25F [29]
Anti-SLITRK6 mAb Ha15-1c25
SLIT and NTRK-like protein 6 (SLITRK6)
Monomethyl auristatin F
Maleimido-caproyl
HA15-1C25E [30]
Anti-SLITRK6 mAb Ha15-1c25
SLIT and NTRK-like protein 6 (SLITRK6)
Monomethyl auristatin E
Mc-Val-Cit-PABC
HA15-1ABE16F [29]
Anti-SLITRK6 mAb Ha15-1abe16
SLIT and NTRK-like protein 6 (SLITRK6)
Monomethyl auristatin F
Maleimido-caproyl
HA15-1ABE16E [30]
Anti-SLITRK6 mAb Ha15-1abe16
SLIT and NTRK-like protein 6 (SLITRK6)
Monomethyl auristatin E
Mc-Val-Cit-PABC
HA15-10AC14F [29]
Anti-SLITRK6 mAb Ha15-10ac14
SLIT and NTRK-like protein 6 (SLITRK6)
Monomethyl auristatin F
Maleimido-caproyl
HA15-10AC14E [30]
Anti-SLITRK6 mAb Ha15-10ac14
SLIT and NTRK-like protein 6 (SLITRK6)
Monomethyl auristatin E
Mc-Val-Cit-PABC
GPC1-ADC-MMAE [31]
Anti-GPC1 GPC1-ADC (MMAE) mAb
Glypican-1 (GPC1)
Monomethyl auristatin E
Mc-Val-Cit-PABC
GPC1-ADC-MMAF [32]
Anti-GPC1 GPC1-ADC mAb
Glypican-1 (GPC1)
Monomethyl auristatin F
Mc-Val-Cit-PABC
LR004-Val-Cit-MMAE [33]
LR004
Epidermal growth factor receptor (EGFR)
Monomethyl auristatin E
Mc-Val-Cit-PABC
EDB-ADC [16]
Anti-EDB-FN L19
Fibronectin (FN1)
Auristatin 0101
Mc-Val-Cit-PABC
4C9-DM1 [19]
Anti-KIT mAb 4C9
Mast/stem cell growth factor receptor Kit (KIT)
Mertansine DM1
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
NN2101-DM1 [34]
NN2101
Mast/stem cell growth factor receptor Kit (KIT)
Mertansine DM1
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
CDH6-SPDB-DM4 [35]
Human Anti-CDH6 mAb
Cadherin-6 (CDH6)
Mertansine DM4
N-succinimidyl 4-(2-pyridyldithio) butanoate (SPDB)
1F6-Val-Cit-PABC-MMAF [36]
Anti-CD70 mAb IF6
CD70 antigen (CD70)
Monomethyl auristatin F
Mal-Val-Cit-PABC
1F6-Ile-Pro-AF [36]
Anti-CD70 mAb IF6
CD70 antigen (CD70)
Auristatin F
Mal-Ile-Pro
1F6-Me3-Lys-Pro-AF [36]
Anti-CD70 mAb IF6
CD70 antigen (CD70)
Auristatin F
Mal-Me3Lys-Pro
1F6-NorVal- (D)Asp-AF [36]
Anti-CD70 mAb IF6
CD70 antigen (CD70)
Auristatin F
Mal-NorVal-D-Asp
1F6-beta-Ala- (D)Asp-AF [36]
Anti-CD70 mAb IF6
CD70 antigen (CD70)
Auristatin F
Mal-bata-Ala-D-Asp
1F6-PhenylGly- (D)Lys-AF [36]
Anti-CD70 mAb IF6
CD70 antigen (CD70)
Auristatin F
Mal-PhenylGly-D-Lys
1F6-Met- (D)Lys-AF [36]
Anti-CD70 mAb IF6
CD70 antigen (CD70)
Auristatin F
Mal-Met-D-Lys
1F6-Asn- (D)Lys-AM [36]
Anti-CD70 mAb IF6
CD70 antigen (CD70)
Auristatin M
Mal-Asn-D-Lys
1F6-Met- (D)Lys-AW [36]
Anti-CD70 mAb IF6
CD70 antigen (CD70)
L-Alanyl-L-tryptophan
Mal-Met-D-Lys
CAC10-Gly5-MAY [37]
Brentuximab
Tumor necrosis factor receptor superfamily member 8 (TNFRSF8)
Mertansine DM1
Gly5
CBR96-Phe-Lys-MMAE [38]
Anti-Lewis-Y mAb cBR96
Lewis Y
Monomethyl auristatin E
Mc-Phe-Lys-PABC
BT062-SPDB-DM4 [39]
Indatuximab
Syndecan-1 (SDC1)
Mertansine DM4
N-succinimidyl 4-(2-pyridyldithio) butanoate (SPDB)
B-B4-DM1 [40]
Cantuzumab
Syndecan-1 (SDC1)
Mertansine DM1
Undisclosed
AXL02 [41]
AXL Anti-ody YW327.6S2
Tyrosine-protein kinase receptor UFO (AXL)
Monomethyl auristatin E
Mc-Val-Cit-PABC
AXL-733-MMAE [42]
AXL-733
Tyrosine-protein kinase receptor UFO (AXL)
Monomethyl auristatin E
Mc-Val-Cit-PABC
AXL-726-M101L-MMAE [42]
AXL-726-M101L
Tyrosine-protein kinase receptor UFO (AXL)
Monomethyl auristatin E
Mc-Val-Cit-PABC
AXL-613-MMAE [42]
AXL-613
Tyrosine-protein kinase receptor UFO (AXL)
Monomethyl auristatin E
Mc-Val-Cit-PABC
AXL-511-MMAE [42]
AXL-511
Tyrosine-protein kinase receptor UFO (AXL)
Monomethyl auristatin E
Mc-Val-Cit-PABC
AXL-183-N52Q-MMAE [42]
AXL-183-N52Q
Tyrosine-protein kinase receptor UFO (AXL)
Monomethyl auristatin E
Mc-Val-Cit-PABC
AXL-171-MMAE [42]
AXL-171
Tyrosine-protein kinase receptor UFO (AXL)
Monomethyl auristatin E
Mc-Val-Cit-PABC
AXL-154-M103L-MMAE [42]
AXL-154-M103L
Tyrosine-protein kinase receptor UFO (AXL)
Monomethyl auristatin E
Mc-Val-Cit-PABC
AXL-148-MMAE [42]
AXL-148
Tyrosine-protein kinase receptor UFO (AXL)
Monomethyl auristatin E
Mc-Val-Cit-PABC
ASG-15MF [29]
Sirtratumab
SLIT and NTRK-like protein 6 (SLITRK6)
Monomethyl auristatin F
Maleimido-caproyl
Anti-IL13RA2-ADC [43]
Anti-IL13RA2 PF-06473811 mAb
Interleukin-13 receptor subunit alpha-2 (IL13RA2)
Auristatin 0101
Mc-Val-Cit-PABC
ADC MMAE/F 4+2 [44]
Trastuzumab N297A
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E+Monomethyl auristatin F
DBCO-PEG3-Glu-Val-Cit-PABC; TCO-PEG3-Glu-Val-Cit-PABC
ADC MMAE/F 2+4 [44]
Trastuzumab N297A
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E+Monomethyl auristatin F
DBCO-PEG3-Glu-Val-Cit-PABC; TCO-PEG3-Glu-Val-Cit-PABC
HuIgG1-SPDB-DM4 [13]
Undisclosed
Folate receptor alpha (FOLR1)
Mertansine DM4
N-succinimidyl 4-(2-pyridyldithio) butanoate (SPDB)
Brentuximab-8 [45]
Brentuximab
Tumor necrosis factor receptor superfamily member 8 (TNFRSF8)
Monomethyl auristatin E
Alkyl phosphoramide-PEG24-Val-Cit-PAB
Brentuximab-7 [45]
Brentuximab
Tumor necrosis factor receptor superfamily member 8 (TNFRSF8)
Monomethyl auristatin E
Alkyl phosphoramide-PEG12-Val-Cit-PAB
Trastuzumab DVD-ADC [46]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin F
Hexapeptide linker ASTKGP
PD-L1 ADC 1 [47]
Avelumab
Programmed cell death 1 ligand 1 (PD-L1)
Monomethyl auristatin E
Mc-Val-Ala-PABC
PD-L1 ADC 2 [47]
Avelumab
Programmed cell death 1 ligand 1 (PD-L1)
Monomethyl auristatin E
Mc-Val-Cit-PABC
PD-L1 ADC 3 [47]
Atezolizumab
Programmed cell death 1 ligand 1 (PD-L1)
Monomethyl auristatin E
Mc-Val-Ala-PABC
T-CpHK-Tet-ADC [48]
Trastuzumab-CpHK
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
Tetrazine-PEG5-Val-Ala-PABC
T-CpHK-Mal-ADC [48]
Trastuzumab-CpHK
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
Mc-Val-Cit-PABC
Trastuzumab-Man-beta-1,4GlcNAc-MMAE [49]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
Man-beta-1,4-GlcNAc
Trastuzumab-Glc-beta-1,4GlcNAc-MMAE [49]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
Glc-beta-1,4GlcNAc
Trastuzumab-Gal-beta-1,4GlcNAc-MMAE [49]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
Gal-beta-1,4-GlcNAc
Trastuzumab-MMAE conjugate DAR2 [50]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
Man-beta-1,4-GlcNAc-DBCO-PEG5-VC-PAB
Trastuzumab-MMAE conjugate DAR4 [50]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
Man-beta-1,4-GlcNAc-DBCO-PEG5-VC-PAB
Trastuzumab-MMAE conjugate DAR6 [50]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
Man-beta-1,4-GlcNAc-DBCO-PEG5-VC-PAB
Trastuzumab-MMAE conjugate DAR8 [50]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
Man-beta-1,4-GlcNAc-DBCO-PEG5-VC-PAB
Trastuzumab-MMAE conjugate DAR12 [50]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
Man-beta-1,4-GlcNAc-DBCO-PEG5-VC-PAB
Anti-HER2 DVD-IgG1-h38c2-K99C_MMAF [51]
Anti-HER2 DVD-IgG1-H38c2-K99C
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin F
Dibromomaleimide-PEG4
Anti-HER2 DVD-Fab-h38c2-K99C_MMAF [51]
Anti-HER2 DVD-Fab-h38c2-K99C
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin F
Dibromomaleimide-PEG4
Anti-HER2 DVD-IgG1_MMAF [51]
Anti-HER2 DVD-IgG1
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin F
Dibromomaleimide-PEG4
Anti-HER2 DVD-Fab_MMAF [51]
Anti-HER2 DVD-Fab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin F
Dibromomaleimide-PEG4
Mil40-12A [27]
Mil40
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
Maleamic methyl ester-based linker 12A
Mil40-12C [27]
Mil40
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
Maleamic methyl ester-based linker 12C
Tras-Gly5-May [37]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Mertansine DM1
Gly5
Fcab-1-MMAE [52]
Fcab-1
Epidermal growth factor receptor (EGFR)
Monomethyl auristatin E
Gly3-Val-Cit-PABC
Fcab-2-MMAE [52]
Fcab-2
Epidermal growth factor receptor (EGFR)
Monomethyl auristatin E
Gly3-Val-Cit-PABC
Fcab-3-MMAE [52]
Fcab-3
Epidermal growth factor receptor (EGFR)
Monomethyl auristatin E
Gly3-Val-Cit-PABC
HuFc-MMAE [52]
Anti-EGFR huFc
Epidermal growth factor receptor (EGFR)
Monomethyl auristatin E
Gly3-Val-Cit-PABC
C-Fab-MMAE [52]
Cetuximab Fab
Epidermal growth factor receptor (EGFR)
Monomethyl auristatin E
Gly3-Val-Cit-PABC
C-IgG-Val-Cit-MMAE [52]
Cetuximab
Epidermal growth factor receptor (EGFR)
Monomethyl auristatin E
Gly3-Val-Cit-PABC
ADC MMAE/F 2+2 [44]
Trastuzumab N297A
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E+Monomethyl auristatin F
DBCO-PEG3-Glu-Val-Cit-PABC; TCO-PEG3-Glu-Val-Cit-PABC
Septuximab vedotin [53]
Septuximab
Frizzled-7 (FZD7)
Monomethyl auristatin E
Mc-Val-Cit-PABC
PeptibodyC19-PEG4-Val-Cit-MMAE [54]
Peptibody C19
Fibroblast growth factor receptor 1 (FGFR1)
Monomethyl auristatin E
Mc-Val-Cit-PABC
40H3-MCVCPAB-MMAE [55]
Anti-EGFR mAb 40H3
Epidermal growth factor receptor (EGFR)
Monomethyl auristatin E
Mc-Val-Cit-PABC
40H3-SMCC-DM1 [55]
Anti-EGFR mAb 40H3
Epidermal growth factor receptor (EGFR)
Mertansine DM1
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
Cet-DM1 [56]
Cetuximab
Epidermal growth factor receptor (EGFR)
Mertansine DM1
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
1F6-Ile-Val-AF [36]
Anti-CD70 mAb IF6
CD70 antigen (CD70)
Auristatin F
Mal-Ile-Val
1F6-Asp-Val-AF [36]
Anti-CD70 mAb IF6
CD70 antigen (CD70)
Auristatin F
Mal-Asp-Val
1F6-His-Val-AF [36]
Anti-CD70 mAb IF6
CD70 antigen (CD70)
Auristatin F
Mal-His-Val
1F6-Met-Lys-AF [36]
Anti-CD70 mAb IF6
CD70 antigen (CD70)
Auristatin F
Mal-Met-Lys
1F6-Asn-Lys-AF [36]
Anti-CD70 mAb IF6
CD70 antigen (CD70)
Auristatin F
Mal-Asn-Lys
1F6-Pro- (D)Lys-AF [36]
Anti-CD70 mAb IF6
CD70 antigen (CD70)
Auristatin F
Mal-Pro-D-Lys
1F6-Met- (D)Lys-MMAF [36]
Anti-CD70 mAb IF6
CD70 antigen (CD70)
Monomethyl auristatin F
Mal-Met-D-Lys
1F6-Asn- (D)Lys-MMAF [36]
Anti-CD70 mAb IF6
CD70 antigen (CD70)
Monomethyl auristatin F
Mal-Asn-D-Lys
1F6-Met- (D)Lys-AM [36]
Anti-CD70 mAb IF6
CD70 antigen (CD70)
Auristatin M
Mal-Met-D-Lys
1F6-Asn- (D)Lys-AW [36]
Anti-CD70 mAb IF6
CD70 antigen (CD70)
L-Alanyl-L-tryptophan
Mal-Asn-D-Lys
MAb-DMBA-SIL-MMAE [57]
Cetuximab
Epidermal growth factor receptor (EGFR)
Monomethyl auristatin E
DMBA-SIL
Alb-DMBA-SIL-MMAE [57]
Alb
Albumin (ALB)
Monomethyl auristatin E
DMBA-SIL
HB22.7-SAP [58]
Anti-CD22 mAb HB22.7
B-cell receptor CD22 (CD22)
Saporin
Undisclosed
GMF-1A3-MMAE [59]
Anti-cleaved-AREG 1A3 Anti-ody
Amphiregulin (AREG)
Monomethyl auristatin E
Mc-Val-Cit-PABC
OMTX705 [60]
OMTX005
Prolyl endopeptidase FAP (FAP)
TAM470
Mc-Val-Cit-PABC-PEG3
Izeltabart tapatansine [61]
Izeltabart
Disintegrin and metalloproteinase domain-containing protein 9 (ADAM9)
DM21-C
Mc-Ala-Ala-Ala
SHR-A1307 [62]
Anti-EGFR mAb hR3-YTE
Epidermal growth factor receptor (EGFR)
SHR152852
L2-MC
CD38-077 [63]
STI-5171
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 (CD38)
Duostatin 5.2
Non-polyethylene glycol linker
BCMA-077 [64]
Undisclosed
Tumor necrosis factor receptor superfamily member 17 (TNFRSF17)
Duostatin 5.2
Proprietary Concortis linker
BCMA-024 [64]
Undisclosed
Tumor necrosis factor receptor superfamily member 17 (TNFRSF17)
Duostatin 5.2
Proprietary Concortis linker
1959-SSS-DM3 [65]
Undisclosed
Galectin-3-binding protein (LGALS3BP)
Maytansinoid DM3
Undisclosed
RN927C [66]
Humanized Anti-Trop-2 hIgG1 Anti-ody
Tumor-associated calcium signal transducer 2 (TACSTD2)
Auristatin 0101
AcLys-Val-Cit-PABC
RN765C [67]
EGFR Ab-L
Epidermal growth factor receptor (EGFR)
Auristatin 0101
AcLys-Val-Cit-PABC
Anti-N3(i)-vc0101 [68]
Anti-NOTCH3(i) mAb
Neurogenic locus notch homolog protein 3 (NOTCH3)
Auristatin 0101
Mc-Val-Cit-PABC
Anti-N3-vc0101 [68]
Anti-NOTCH3 mAb
Neurogenic locus notch homolog protein 3 (NOTCH3)
Auristatin 0101
Mc-Val-Cit-PABC
Alpha-CLDN-VC0101 [69]
Undisclosed
Claudin-18.2 (CLDN18.2)
Auristatin 0101
Mc-Val-Cit-PABC
MP-1959-ADC [70]
Anti-LGALS3BP mAb 1959-sss
Galectin-3-binding protein (LGALS3BP)
Maytansinoid
Undisclosed
M9346A Sulfo-SPDB DM4 [13]
Mirvetuximab
Folate receptor alpha (FOLR1)
Mertansine DM4
Sulfo-SPDB
Anti-FcRL5-SPDB-DM4 [71]
Anti-FcRL5 mAb
Fc receptor-like protein 5 (FCRL5)
Mertansine DM4
N-succinimidyl 4-(2-pyridyldithio) butanoate (SPDB)
Anti-CD22-SPDB-DM4 [72]
Anti-CD22 Anti-ody (LC-K149C)
B-cell receptor CD22 (CD22)
Mertansine DM4
N-succinimidyl 4-(2-pyridyldithio) butanoate (SPDB)
Anti-CD22-K149C-MBT-DM4 [72]
Anti-CD22 Anti-ody (LC-K149C)
B-cell receptor CD22 (CD22)
Mertansine DM4
MBT
HuRH105-SSPDB-DM4 [73]
Undisclosed
Endoglin (ENG)
Mertansine DM4
Sulfo-SPDB
IMB-102 [74]
Undisclosed
Cathepsin D (CTSD)
Mertansine DM4
N-succinimidyl 4-(2-pyridyldithio) butanoate (SPDB)
CBX-13 [75]
Undisclosed
Undisclosed
Mertansine DM4
Undisclosed
Oberotatug ravtansine [76]
Oberotatug
Lymphocyte antigen 75 (LY75)
DM4
N-succinimidyl 4-(2-pyridyldithio) butanoate (SPDB)
Oba01 [77]
Zaptuzumab
Tumor necrosis factor receptor superfamily member 10B (TNFRSF10B)
Monomethyl auristatin E
PY-MAA-Val-Cit-PABC
Anti-HER2 antibody-drug conjugate (Spirea) [78]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
Undisclosed
TTZ-Mc-NPV-MMAE [79]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
Mc-Asn-Pro-Val-PABC
Adcitmer [80]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
Pyridino-caproic-Val-Cit-PABC
Trastuzumab-BCN-HydraSpace-Val-Cit-PABC-MMAE [24]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
BCN-HydraSpace-Val-Cit-PABC
MF-TTZ-MMAE [81]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
Dibromomethyl pyridine-Val-Cit-PABC
FGM-TTZ-MMAE [81]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
Mc-Val-Cit-PABC
NC-ADC [82]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
Divinylpyrimidine-PEG4
C-ADC [82]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
Divinylpyrimidine-PEG4-Val-Ala-PABC
RC68-PY-Val-Cit-PABC-MMAE [83]
RC68
Epidermal growth factor receptor (EGFR)
Monomethyl auristatin E
PY-VC-PABC
RC68-Mc-Val-Cit-PABC-MMAE [83]
RC68
Epidermal growth factor receptor (EGFR)
Monomethyl auristatin E
Mc-Val-Cit-PABC
PCM-MET01-MMAE [84]
PCM-MET01
Hepatocyte growth factor receptor (MET)
Monomethyl auristatin E
Mc-Val-Cit-PABC
Pab-001-MMAE [85]
Pab-001
Mucin-1 (MUC1)
Monomethyl auristatin E
Undisclosed
OBI-998 [86]
OBI-898
Stage-specific embryonic antigen-4 (SSEA-4)
Monomethyl auristatin E
Maleimide and PEGylated cleavable linker
Anti-ICOS-MMAE [87]
Murine Anti-ICOS Anti-ody
Inducible T-cell costimulator (ICOS)
Monomethyl auristatin E
Undisclosed
Mil40-12B [27]
Mil40
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
Mc-Val-Cit-PABC
Magacizumab PD-MMAE ADC 5 [22]
Magacizumab
Leucine-rich alpha-2-glycoprotein (LRG1)
Monomethyl auristatin E
Mepstra-PD-PEG3-Mal-Cit-PABC
1F-Val-Cit-MMAE [15]
Anit-TF mAb 1F
Tissue factor (F3)
Monomethyl auristatin E
Mc-Val-Cit-PABC
BVD-TEM8 ADC [88]
Anti-TEM8 mAb m825
Anthrax toxin receptor 1 (ANTXR1)
Monomethyl auristatin E
Mc-Val-Cit-PABC
IMAB362-Val-Cit-MMAE [89]
IMAB362
Claudin-18.2 (CLDN18.2)
Monomethyl auristatin E
Mc-Val-Cit-PABC
IMAB027-Val-Cit-MMAE [90]
IMAB027
Claudin-6 (CLDN6)
Monomethyl auristatin E
Mc-Val-Cit-PABC
SS1-Val-Cit-MMAE [91]
Anti-MSLN IgG1-SS1
Mesothelin (MSLN)
Monomethyl auristatin E
Mc-Val-Cit-PABC
CHS8-Val-Cit-MMAE [91]
Anti-MSLN IgG1-CHS8
Mesothelin (MSLN)
Monomethyl auristatin E
Mc-Val-Cit-PABC
CHS7-Val-Cit-MMAE [91]
Anti-MSLN IgG1-CHS7
Mesothelin (MSLN)
Monomethyl auristatin E
Mc-Val-Cit-PABC
CHS5-Val-Cit-MMAE [91]
Anti-MSLN IgG1-CHS5
Mesothelin (MSLN)
Monomethyl auristatin E
Mc-Val-Cit-PABC
ALA12-Val-Cit-MMAE [91]
Anti-MSLN IgG1-ALA12
Mesothelin (MSLN)
Monomethyl auristatin E
Mc-Val-Cit-PABC
Bstrongximab ADC [92]
Bstrongximab
TRA-1-60
Monomethyl auristatin E
Mc-Val-Cit-PABC
T-Fc-Val-Cit-MMAE [93]
Human Anti-FGFR1 Fc
Fibroblast growth factor receptor 1 (FGFR1)
Monomethyl auristatin E
Mc-Val-Cit-PABC
Anti-CD7 MMAE ADC [94]
Human Anti-CD7 mAb IgG1
T-cell antigen CD7 (CD7)
Monomethyl auristatin E
PermaLink-PEG4-Val-Cit-PAB
PCM5B14-MMAE [95]
H5B14
Macrophage-stimulating protein receptor (MST1R)
Monomethyl auristatin E
Mc-Val-Cit-PABC
GB7008-01-Val-Cit-MMAE [96]
GB7008-01
Claudin-6 (CLDN6)
Monomethyl auristatin E
Mc-Val-Cit-PABC
F7-ADC [53]
F7-Chimeric Ab
Frizzled-7 (FZD7)
Monomethyl auristatin E
Mc-Val-Cit-PABC
Cirmtuzumab-ADC-7 [97]
Cirmtuzumab
Inactive tyrosine-protein kinase transmembrane receptor ROR1 (ROR1)
Monomethyl auristatin E
Undisclosed
CDX3379-MMAE [98]
CDX3379
Receptor tyrosine-protein kinase erbB-3 (HER3)
Monomethyl auristatin E
Mc-Val-Cit-PABC
MF-BTX-MMAE [99]
Brentuximab
Tumor necrosis factor receptor superfamily member 8 (TNFRSF8)
Monomethyl auristatin E
Dibromomethyl pyridine-Val-Cit-PABC
ADC-AVP-04 [100]
AVP04
Tumor-associated glycoprotein 72 (TAG-72)
Monomethyl auristatin E
Maleimide-functionalized TCO
Atezolizumab ADC [47]
Atezolizumab
Programmed cell death 1 ligand 1 (PD-L1)
Monomethyl auristatin E
Mc-Val-Cit-PABC
S3F-CL-MMAE [101]
Anti-sTn mAb S3F
Onco-foetal sialyl-Tn
Monomethyl auristatin E
Mc-Val-Cit-PABC
111In-DTPA-D2B-DAR4-MMAE [102]
Anti-PSMA IgG1 mAb D2B
Glutamate carboxypeptidase 2 (FOLH1)
Monomethyl auristatin E
Mc-Val-Cit-PABC
111In-DTPA-D2B-DAR2-MMAE [102]
Anti-PSMA IgG1 mAb D2B
Glutamate carboxypeptidase 2 (FOLH1)
Monomethyl auristatin E
Mc-Val-Cit-PABC
Anti-FcRL5-Mc-vcPAB-MMAE [103]
Anti-FcRL5 mAb
Fc receptor-like protein 5 (FCRL5)
Monomethyl auristatin E
Mc-Val-Cit-PABC
DAR8-alphaCD30-mDPR-Gluc-MMAE [104]
Anti-CD30 DAR8-alphaCD30-mDPR-gluc-MMAE mAb
Tumor necrosis factor receptor superfamily member 8 (TNFRSF8)
Monomethyl auristatin E
Quaternary ammonium linker Gluc
A7R-ADC-MMAE [105]
Anti-IL7R mAb A7R
Interleukin-7 receptor subunit alpha (IL7R)
Monomethyl auristatin E
Mal-PEG12-Val-Cit-PABC
S7-E430G ADC [106]
9G8-7D12-Fc with E430G
Epidermal growth factor receptor (EGFR)
Monomethyl auristatin E
Mc-Val-Cit-PABC
S7 ADC [106]
9G8-7D12-Fc
Epidermal growth factor receptor (EGFR)
Monomethyl auristatin E
Mc-Val-Cit-PABC
7H5-Val-Cit-MMAE [107]
Anti-TIP1 mAb 7H5
Tax1-binding protein 3 (TAX1BP3)
Monomethyl auristatin E
Mc-Val-Cit-PABC
N41mab-Val-Cit-MMAE [108]
Undisclosed
Nectin-4 (NECTIN4)
Monomethyl auristatin E
Mc-Val-Cit-PABC
ST1 [109]
Undisclosed
Onco-foetal sialyl-Tn
Monomethyl auristatin E
Undisclosed
JY207 [110]
Undisclosed
Leukocyte surface antigen CD47 (CD47); Programmed cell death 1 ligand 1 (PD-L1)
Monomethyl auristatin E
Undisclosed
Hertuzumab vedotin [111]
Hertuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
Mc-Val-Cit-PABC
LCB-97 [112]
Undisclosed
AF4/FMR2 family member 4 (AFF4)
Monomethyl auristatin E
Undisclosed
LCB-67 [113]
Undisclosed
Protein delta homolog 1 (DLK1)
Monomethyl auristatin E
Undisclosed
Anti-endosialin-Mc-Val-Cit-PABC-MMAE [114]
Undisclosed
Endosialin (CD248)
Monomethyl auristatin E
Mc-Val-Cit-PABC
Anti-NaPi3b antibody-drug conjugate (Genentech/Roche) [115]
Undisclosed
Sodium-dependent phosphate transport protein 2B (SLC34A2)
Monomethyl auristatin E
Undisclosed
DM003 [116]
Undisclosed
Inactive tyrosine-protein kinase 7 (PTK7); Epidermal growth factor receptor (EGFR)
Monomethyl auristatin E
Undisclosed
MSLN ADC (Development Center for Biotechnology) [117]
Undisclosed
Mesothelin (MSLN)
Monomethyl auristatin E
Undisclosed
CBX-15 [75]
Undisclosed
Poly [ADP-ribose] polymerase 1 (PARP1)
Monomethyl auristatin E
Undisclosed
YH-012 [118]
Undisclosed
Receptor tyrosine-protein kinase erbB-2 (HER2); Tumor-associated calcium signal transducer 2 (TACSTD2)
Monomethyl auristatin E
Mc-Val-Cit-PABC
YH-013 [119]
Undisclosed
Epidermal growth factor receptor (EGFR); Hepatocyte growth factor receptor (MET)
Monomethyl auristatin E
Mc-Val-Cit-PABC
DM004 [120]
Undisclosed
Trophoblast glycoprotein (TPBG); Hepatocyte growth factor receptor (MET)
Monomethyl auristatin E
Undisclosed
BSA01 [121]
Undisclosed
Epidermal growth factor receptor (EGFR); Mucin-1 (MUC1)
Monomethyl auristatin E
Undisclosed
BCG033 [122]
Undisclosed
Tumor-associated calcium signal transducer 2 (TACSTD2); Inactive tyrosine-protein kinase 7 (PTK7)
Monomethyl auristatin E
Undisclosed
BCG022 [123]
Undisclosed
Receptor tyrosine-protein kinase erbB-3 (HER3); Hepatocyte growth factor receptor (MET)
Monomethyl auristatin E
Undisclosed
BA-3361 [124]
Undisclosed
Nectin-4 (NECTIN4)
Monomethyl auristatin E
Mc-Val-Cit-PABC
CD46 CAB-ADC [125]
Undisclosed
Membrane cofactor protein (CD46)
Monomethyl auristatin E
Mc-Val-Cit-PABC
ARC-02 [126]
Undisclosed
B-cell antigen receptor complex-associated protein beta chain (CD79B)
Monomethyl auristatin E
Undisclosed
MSLN MMAE [127]
Undisclosed
Mesothelin (MSLN)
Monomethyl auristatin E
Undisclosed
B7H3-MMAE [128]
Undisclosed
CD276 antigen (CD276)
Monomethyl auristatin E
Undisclosed
Tmab-SPDP-DM1 [25]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Mertansine DM1
N-succinimidyl 4-(2-pyridyldithio) butanoate (SPDB)
REGN2878-DM1 [129]
REGN2878
Prolactin receptor (PRLR)
Mertansine DM1
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
BT062-SPP-DM1 [39]
Indatuximab
Syndecan-1 (SDC1)
Mertansine DM1
N-succinimidyl 4-(2-pyridyldithio) pentanoate (SPP)
BT062-SMCC-DM1 [39]
Indatuximab
Syndecan-1 (SDC1)
Mertansine DM1
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
MD1.22-DM1 [130]
mD1.22
Envelope glycoprotein gp160 (env)
Mertansine DM1
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
LR-DM1 [131]
LR004
Epidermal growth factor receptor (EGFR)
Mertansine DM1
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
HJAA-F11 ADC [132]
JAA-F11
Tissue factor (F3)
Mertansine DM1
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
IIIA4-USAN [133]
Anti-EPHA3 mAb IIIA4
Ephrin type-A receptor 3 (EPHA3)
Mertansine DM1
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
IgG78-DM1 [134]
Anti-CD248 mAb IgG78
Endosialin (CD248)
Mertansine DM1
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
ICAM1-DM1 ADC [135]
Anti-ICAM1 mAb
Intercellular adhesion molecule 1 (ICAM1)
Mertansine DM1
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
DS6-DM1 [136]
Anti-MUC1 mAb DS6
Mucin-1 (MUC1)
Mertansine DM1
N-succinimidyl 4-(2-pyridyldithio) butanoate (SPDB)
DL35D-DM1 [130]
DL35D
Envelope glycoprotein gp160 (env); Envelope glycoprotein gp41 (env)
Mertansine DM1
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
Zt/g4-DM1 [137]
Anti-RON Zt/g4 (IgG1 kappa)
Macrophage-stimulating protein receptor (MST1R)
Mertansine DM1
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
Anti-SSTR2 ADC [138]
Anti-human and mouse SSTR2 mAb (IgG1 kappa)
Somatostatin receptor type 2 (SSTR2)
Mertansine DM1
Sulfo-SMCC
FMOD-ADC [139]
Anti-FMOD mAb
Fibromodulin (FMOD)
Mertansine DM1
Sulfo-SMCC
Anti-EGFR-PEG4-Mal-DM1 [140]
Anti-EGFR mAb rat IgG2a
Epidermal growth factor receptor (EGFR)
Mertansine DM1
PEG4-Mal
Anti-EGFR-Sulfo-SMCC-DM1 [141]
Anti-EGFR mAb
Epidermal growth factor receptor (EGFR)
Mertansine DM1
Sulfo-SMCC
Anti-CD47 mAb (IgG2b/kappa)-DM1 [142]
Anti-CD47 mAb (IgG2b/kappa)-
Leukocyte surface antigen CD47 (CD47)
Mertansine DM1
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
Anti-CD22-K149C-MPEO-DM1 [72]
Anti-CD22 Anti-ody (LC-K149C)
B-cell receptor CD22 (CD22)
Mertansine DM1
MPEO
Anti-CD22-K149C-DM1 [72]
Anti-CD22 Anti-ody (LC-K149C)
B-cell receptor CD22 (CD22)
Mertansine DM1
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
2G4-DM1 [143]
Anti-KIT mAb 2G4
Mast/stem cell growth factor receptor Kit (KIT)
Mertansine DM1
Undisclosed
Zt/g4-Maytansinoid [137]
Undisclosed
Macrophage-stimulating protein receptor (MST1R)
Mertansine DM1
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
APLP2/HER2 antibody-drug conjugate [144]
Undisclosed
Amyloid beta precursor like protein 2 (APLP2); Receptor tyrosine-protein kinase erbB-2 (HER2)
Mertansine DM1
Undisclosed
PTM-001-ADC [145]
Undisclosed
Undisclosed
Mertansine DM1
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
HuRH105-SMCC-DM1 [73]
Undisclosed
Endoglin (ENG)
Mertansine DM1
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
IMB-101 [74]
Undisclosed
Cathepsin D (CTSD)
Mertansine DM1
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
CTAT-ADC [146]
Undisclosed
Receptor tyrosine-protein kinase erbB-2 (HER2)
Mertansine DM1
Undisclosed
Humanized Anti-HER2 Mab-Maytansine Conjugate [147]
Undisclosed
Receptor tyrosine-protein kinase erbB-2 (HER2)
Mertansine DM1
Undisclosed
ZV-0501 [148]
ZV05
Trophoblast glycoprotein (TPBG)
Monomethyl auristatin F
Maleimido-caproyl
CD70-MMAF-ADC [149]
Vorsetuzumab
CD70 antigen (CD70)
Monomethyl auristatin F
Maleimido-caproyl
Anti-TrkB DVD-ADC [46]
TrkB-DVD (h38C2)
BDNF/NT-3 growth factors receptor (NTRK2)
Monomethyl auristatin F
Hexapeptide linker ASTKGP
T-K-F (DAR 3.9) [150]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin F
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
T-C-F (DAR 3.7) [150]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin F
Maleimido-caproyl
SG3-Val-Cit-MMAF8 [151]
SG3
Tumor necrosis factor receptor superfamily member 17 (TNFRSF17)
Monomethyl auristatin F
Mc-Val-Cit-PABC
SG2-Val-Cit-MMAF8 [151]
SG2
Tumor necrosis factor receptor superfamily member 17 (TNFRSF17)
Monomethyl auristatin F
Mc-Val-Cit-PABC
SG1-Val-Cit-MMAF8 [151]
SG1
Tumor necrosis factor receptor superfamily member 17 (TNFRSF17)
Monomethyl auristatin F
Mc-Val-Cit-PABC
LCB-ADC3 [152]
Isoprenylated trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin F
Bridged PEG4-valine-alanine
LCB-ADC2 [152]
Isoprenylated trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin F
Isoprene-PEG3,3,3-beta-Glu-PABC
LCB-ADC1 [152]
Isoprenylated trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin F
Isoprene-PEG3-beta-Glu-PABC
DAR2-ARC-ADC [153]
Human hCLL-1 Anti-ody genetically fused with CD38
Collectin-10 (COLEC10)
Monomethyl auristatin F
NAD-based dinucleotide linker
EV20/MMAF [154]
EV20
Receptor tyrosine-protein kinase erbB-3 (HER3)
Monomethyl auristatin F
Maleimido-caproyl
Anti-TrkB mAb 641 ADC [46]
Anti-TrkB mAb 641
BDNF/NT-3 growth factors receptor (NTRK2)
Monomethyl auristatin F
Hexapeptide linker ASTKGP
CD46-ADC [155]
Anti-CD46 mAb 23AG2
Membrane cofactor protein (CD46)
Monomethyl auristatin F
Mc-Val-Cit-PABC
MP-HER3-ADC [156]
Undisclosed
Receptor tyrosine-protein kinase erbB-3 (HER3)
Monomethyl auristatin F
Undisclosed
AVP10 [157]
Undisclosed
Tumor necrosis factor receptor superfamily member 8 (TNFRSF8)
Monomethyl auristatin F
Undisclosed
DAR4-ARC-ADC [153]
Undisclosed
Collectin-10 (COLEC10)
Monomethyl auristatin F
NAD-based dinucleotide linker
NC-6201 [158]
NCAB001
Epidermal growth factor receptor (EGFR)
E7974
Undisclosed
An2-anti-HER2-Doxetaxel [159]
ANG4043
Receptor tyrosine-protein kinase erbB-2 (HER2)
Docetaxel
Undisclosed
APH-0912 [160]
Undisclosed
Undisclosed
Docetaxel
Hydrophilic linker containing sugar molecules
DAR8-alphaCD30-mDPR-GlucQ-AE [104]
Anti-CD30 DAR8-alphaCD30-mDPR-glucQ-AE mAb
Tumor necrosis factor receptor superfamily member 8 (TNFRSF8)
Auristatin E
Quaternary ammonium linker GlucQ
T-N-F (DAR 3.2) [150]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Aldehyde-tagged MMAF
Undisclosed
T-N-F (DAR 1.6) [150]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Aldehyde-tagged MMAF
Undisclosed
1F6-Asn- (D)Lys-AF [36]
Anti-CD70 mAb IF6
CD70 antigen (CD70)
Auristatin F
Mal-Asn-D-Lys
Erbitux-MHT-71 [161]
Cetuximab
Epidermal growth factor receptor (EGFR)
Auristatin F
MHT-71
4D5-AF (CUAAC) [162]
Anti-HER2/neu mAb 4D5
Receptor tyrosine-protein kinase erbB-2 (HER2)
Auristatin F
N6-(2-azidoethoxy)carbonyl-L-lysine
DAN-405 [163]
Undisclosed
Glutamate carboxypeptidase 2 (FOLH1)
Cabazitaxel
Undisclosed
Anti-HER2 scFv-Fc (Ser396Sec)-CN29 [164]
Anti-HER2 scFv-Fc (Ser396Sec)
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin F derivative peptide (CN29)
Lodoacetamido-caproyl
Trastuzumab-deBouganin [165]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
DeBouganin
Undisclosed
DAR8-alphaCD30-mDPR-Gluc-DMTub [104]
Anti-CD30 DAR8-alphaCD30-mDPR-gluc-DMTub mAb
Tumor necrosis factor receptor superfamily member 8 (TNFRSF8)
DMTub
Quaternary ammonium linker Gluc
Eribulin ADC (Jiangsu hengrui) [166]
Undisclosed
Undisclosed
Eribulin
Undisclosed
MET/MET-M114 [167]
Biparatopic METxMET Anti-ody
Hepatocyte growth factor receptor (MET); Hepatocyte growth factor receptor (MET)
Maytansine derivative M24
Succinate-Val-Cit-PABC
CBT-3112 [168]
Undisclosed
Serine/threonine-protein kinase DCLK1 (DCLK1)
Paclitaxel
Undisclosed
MI-130004 [169]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
PM050489
6-(2,5-dioxopyrrol-1-yl)-N-Propylhexanamide
MI-130110 [170]
Anti-CD13 TEA1/8 mAb
Aminopeptidase N (ANPEP)
PM050489
6-(2,5-dioxopyrrol-1-yl)-N-Propylhexanamide
Monoclonal antibody HB2-saporin conjugate [171]
Anti-CD7 mAb HB2
T-cell antigen CD7 (CD7)
Saporin
Undisclosed
Anti-CD30 monoclonal antibody-saporin conjugate [172]
Anti-CD30 mAb Ber-H2
Tumor necrosis factor receptor superfamily member 8 (TNFRSF8)
Saporin
Undisclosed
33B7-Saporin [173]
Anti-PTGFRN mAb 33B7
Prostaglandin F2 receptor negative regulator (PTGFRN)
Saporin
Undisclosed
Anti-CD38 IT OKT10-SAPORIN [174]
Undisclosed
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 (CD38)
Saporin
Undisclosed
Anti-HER2 DVD-IgG1-Tiancimycin [175]
Anti-HER2 DVD-IgG1
Receptor tyrosine-protein kinase erbB-2 (HER2)
Tiancimycin
DVD-PEG4-Triazol
DAR8-alphaCD30-mDPR-GlucQ-Tub [104]
Anti-CD30 DAR8-alphaCD30-mDPR-glucQ-Tub mAb
Tumor necrosis factor receptor superfamily member 8 (TNFRSF8)
Tubulysin analogue 3
Quaternary ammonium linker GlucQ
LY3343544 [176]
Emibetuzumab
Hepatocyte growth factor receptor (MET)
Monomethyl auristatin E
Undisclosed
BB-1712 [177]
Anti-B7-H3 mAb
CD276 antigen (CD276)
Eribulin
A cleavable linker
Araris ADC [178]
Enfortumab
Nectin-4 (NECTIN4)
Monomethyl auristatin E
Cathepsin B cleavable linker
MP-EV-20 [179]
EV20
Receptor tyrosine-protein kinase erbB-3 (HER3)
Monomethyl auristatin F
Undisclosed
GENA-111-AF [180]
GENA-111
Tumor necrosis factor receptor superfamily member 17 (TNFRSF17)
Monomethyl auristatin F
Undisclosed
AG 02 saporin conjugate [181]
Anti-CSP-1 mAb AG02
Cell surface protein 1 (CSP-1)
Saporin
Undisclosed
SC16.3-DL1 [182]
SC16.3
Delta-like protein 3 (DLL3)
SG2000 derivative PBD 1
Mal-PEG8-Val-Ala
SC16.4-DL1 [182]
SC16.4
Delta-like protein 3 (DLL3)
SG2000 derivative PBD 1
Mal-PEG8-Val-Ala
SC16.5-DL1 [182]
SC16.5
Delta-like protein 3 (DLL3)
SG2000 derivative PBD 1
Mal-PEG8-Val-Ala
SC16.7-DL1 [182]
SC16.7
Delta-like protein 3 (DLL3)
SG2000 derivative PBD 1
Mal-PEG8-Val-Ala
SC16.8-DL1 [182]
SC16.8
Delta-like protein 3 (DLL3)
SG2000 derivative PBD 1
Mal-PEG8-Val-Ala
SC16.10-DL1 [182]
SC16.10
Delta-like protein 3 (DLL3)
SG2000 derivative PBD 1
Mal-PEG8-Val-Ala
SC16.11-DL1 [182]
SC16.11
Delta-like protein 3 (DLL3)
SG2000 derivative PBD 1
Mal-PEG8-Val-Ala
SC16.13-DL1 [182]
SC16.13
Delta-like protein 3 (DLL3)
SG2000 derivative PBD 1
Mal-PEG8-Val-Ala
SC16.15-DL1 [182]
SC16.15
Delta-like protein 3 (DLL3)
SG2000 derivative PBD 1
Mal-PEG8-Val-Ala
SC16.18-DL1 [182]
SC16.18
Delta-like protein 3 (DLL3)
SG2000 derivative PBD 1
Mal-PEG8-Val-Ala
SC16.19-DL1 [182]
SC16.19
Delta-like protein 3 (DLL3)
SG2000 derivative PBD 1
Mal-PEG8-Val-Ala
SC16.20-DL1 [182]
SC16.20
Delta-like protein 3 (DLL3)
SG2000 derivative PBD 1
Mal-PEG8-Val-Ala
SC16.21-DL1 [182]
SC16.21
Delta-like protein 3 (DLL3)
SG2000 derivative PBD 1
Mal-PEG8-Val-Ala
SC16.22-DL1 [182]
SC16.22
Delta-like protein 3 (DLL3)
SG2000 derivative PBD 1
Mal-PEG8-Val-Ala
SC16.23-DL1 [182]
SC16.23
Delta-like protein 3 (DLL3)
SG2000 derivative PBD 1
Mal-PEG8-Val-Ala
SC16.25-DL1 [182]
SC16.25
Delta-like protein 3 (DLL3)
SG2000 derivative PBD 1
Mal-PEG8-Val-Ala
SC16.26-DL1 [182]
SC16.26
Delta-like protein 3 (DLL3)
SG2000 derivative PBD 1
Mal-PEG8-Val-Ala
SC16.29-DL1 [182]
SC16.29
Delta-like protein 3 (DLL3)
SG2000 derivative PBD 1
Mal-PEG8-Val-Ala
SC16.30-DL1 [182]
SC16.30
Delta-like protein 3 (DLL3)
SG2000 derivative PBD 1
Mal-PEG8-Val-Ala
SC16.31-DL1 [182]
SC16.31
Delta-like protein 3 (DLL3)
SG2000 derivative PBD 1
Mal-PEG8-Val-Ala
SC16.34-DL1 [182]
SC16.34
Delta-like protein 3 (DLL3)
SG2000 derivative PBD 1
Mal-PEG8-Val-Ala
SC16.35-DL1 [182]
SC16.35
Delta-like protein 3 (DLL3)
SG2000 derivative PBD 1
Mal-PEG8-Val-Ala
SC16.36-DL1 [182]
SC16.36
Delta-like protein 3 (DLL3)
SG2000 derivative PBD 1
Mal-PEG8-Val-Ala
SC16.38-DL1 [182]
SC16.38
Delta-like protein 3 (DLL3)
SG2000 derivative PBD 1
Mal-PEG8-Val-Ala
SC16.41-DL1 [182]
SC16.41
Delta-like protein 3 (DLL3)
SG2000 derivative PBD 1
Mal-PEG8-Val-Ala
SC16.42-DL1 [182]
SC16.42
Delta-like protein 3 (DLL3)
SG2000 derivative PBD 1
Mal-PEG8-Val-Ala
SC16.45-DL1 [182]
SC16.45
Delta-like protein 3 (DLL3)
SG2000 derivative PBD 1
Mal-PEG8-Val-Ala
SC16.47-DL1 [182]
SC16.47
Delta-like protein 3 (DLL3)
SG2000 derivative PBD 1
Mal-PEG8-Val-Ala
SC16.49-DL1 [182]
SC16.49
Delta-like protein 3 (DLL3)
SG2000 derivative PBD 1
Mal-PEG8-Val-Ala
SC16.50-DL1 [182]
SC16.50
Delta-like protein 3 (DLL3)
SG2000 derivative PBD 1
Mal-PEG8-Val-Ala
SC16.52-DL1 [182]
SC16.52
Delta-like protein 3 (DLL3)
SG2000 derivative PBD 1
Mal-PEG8-Val-Ala
SC16.55-DL1 [182]
SC16.55
Delta-like protein 3 (DLL3)
SG2000 derivative PBD 1
Mal-PEG8-Val-Ala
SC16.56-DL1 [182]
SC16.56
Delta-like protein 3 (DLL3)
SG2000 derivative PBD 1
Mal-PEG8-Val-Ala
SC16.57-DL1 [182]
SC16.57
Delta-like protein 3 (DLL3)
SG2000 derivative PBD 1
Mal-PEG8-Val-Ala
SC16.58-DL1 [182]
SC16.58
Delta-like protein 3 (DLL3)
SG2000 derivative PBD 1
Mal-PEG8-Val-Ala
SC16.61-DL1 [182]
SC16.61
Delta-like protein 3 (DLL3)
SG2000 derivative PBD 1
Mal-PEG8-Val-Ala
SC16.62-DL1 [182]
SC16.62
Delta-like protein 3 (DLL3)
SG2000 derivative PBD 1
Mal-PEG8-Val-Ala
SC16.63-DL1 [182]
SC16.63
Delta-like protein 3 (DLL3)
SG2000 derivative PBD 1
Mal-PEG8-Val-Ala
SC16.65-DL1 [182]
SC16.65
Delta-like protein 3 (DLL3)
SG2000 derivative PBD 1
Mal-PEG8-Val-Ala
SC16.67-DL1 [182]
SC16.67
Delta-like protein 3 (DLL3)
SG2000 derivative PBD 1
Mal-PEG8-Val-Ala
SC16.68-DL1 [182]
SC16.68
Delta-like protein 3 (DLL3)
SG2000 derivative PBD 1
Mal-PEG8-Val-Ala
SC16.72-DL1 [182]
SC16.72
Delta-like protein 3 (DLL3)
SG2000 derivative PBD 1
Mal-PEG8-Val-Ala
SC16.73-DL1 [182]
SC16.73
Delta-like protein 3 (DLL3)
SG2000 derivative PBD 1
Mal-PEG8-Val-Ala
SC16.78-DL1 [182]
SC16.78
Delta-like protein 3 (DLL3)
SG2000 derivative PBD 1
Mal-PEG8-Val-Ala
SC16.79-DL1 [182]
SC16.79
Delta-like protein 3 (DLL3)
SG2000 derivative PBD 1
Mal-PEG8-Val-Ala
SC16.80-DL1 [182]
SC16.80
Delta-like protein 3 (DLL3)
SG2000 derivative PBD 1
Mal-PEG8-Val-Ala
SC16.81-DL1 [182]
SC16.81
Delta-like protein 3 (DLL3)
SG2000 derivative PBD 1
Mal-PEG8-Val-Ala
SC16.84-DL1 [182]
SC16.84
Delta-like protein 3 (DLL3)
SG2000 derivative PBD 1
Mal-PEG8-Val-Ala
SC16.88-DL1 [182]
SC16.88
Delta-like protein 3 (DLL3)
SG2000 derivative PBD 1
Mal-PEG8-Val-Ala
SC16.101-DL1 [182]
SC16.101
Delta-like protein 3 (DLL3)
SG2000 derivative PBD 1
Mal-PEG8-Val-Ala
SC16.103-DL1 [182]
SC16.103
Delta-like protein 3 (DLL3)
SG2000 derivative PBD 1
Mal-PEG8-Val-Ala
SC16.104-DL1 [182]
SC16.104
Delta-like protein 3 (DLL3)
SG2000 derivative PBD 1
Mal-PEG8-Val-Ala
SC16.105-DL1 [182]
SC16.105
Delta-like protein 3 (DLL3)
SG2000 derivative PBD 1
Mal-PEG8-Val-Ala
SC16.106-DL1 [182]
SC16.106
Delta-like protein 3 (DLL3)
SG2000 derivative PBD 1
Mal-PEG8-Val-Ala
SC16.107-DL1 [182]
SC16.107
Delta-like protein 3 (DLL3)
SG2000 derivative PBD 1
Mal-PEG8-Val-Ala
SC16.108-DL1 [182]
SC16.108
Delta-like protein 3 (DLL3)
SG2000 derivative PBD 1
Mal-PEG8-Val-Ala
SC16.109-DL1 [182]
SC16.109
Delta-like protein 3 (DLL3)
SG2000 derivative PBD 1
Mal-PEG8-Val-Ala
SC16.110-DL1 [182]
SC16.110
Delta-like protein 3 (DLL3)
SG2000 derivative PBD 1
Mal-PEG8-Val-Ala
SC16.111-DL1 [182]
SC16.111
Delta-like protein 3 (DLL3)
SG2000 derivative PBD 1
Mal-PEG8-Val-Ala
SC16.113-DL1 [182]
SC16.113
Delta-like protein 3 (DLL3)
SG2000 derivative PBD 1
Mal-PEG8-Val-Ala
SC16.114-DL1 [182]
SC16.114
Delta-like protein 3 (DLL3)
SG2000 derivative PBD 1
Mal-PEG8-Val-Ala
SC16.115-DL1 [182]
SC16.115
Delta-like protein 3 (DLL3)
SG2000 derivative PBD 1
Mal-PEG8-Val-Ala
SC16.116-DL1 [182]
SC16.116
Delta-like protein 3 (DLL3)
SG2000 derivative PBD 1
Mal-PEG8-Val-Ala
SC16.117-DL1 [182]
SC16.117
Delta-like protein 3 (DLL3)
SG2000 derivative PBD 1
Mal-PEG8-Val-Ala
SC16.118-DL1 [182]
SC16.118
Delta-like protein 3 (DLL3)
SG2000 derivative PBD 1
Mal-PEG8-Val-Ala
SC16.120-DL1 [182]
SC16.120
Delta-like protein 3 (DLL3)
SG2000 derivative PBD 1
Mal-PEG8-Val-Ala
SC16.121-DL1 [182]
SC16.121
Delta-like protein 3 (DLL3)
SG2000 derivative PBD 1
Mal-PEG8-Val-Ala
SC16.122-DL1 [182]
SC16.122
Delta-like protein 3 (DLL3)
SG2000 derivative PBD 1
Mal-PEG8-Val-Ala
SC16.123-DL1 [182]
SC16.123
Delta-like protein 3 (DLL3)
SG2000 derivative PBD 1
Mal-PEG8-Val-Ala
SC16.124-DL1 [182]
SC16.124
Delta-like protein 3 (DLL3)
SG2000 derivative PBD 1
Mal-PEG8-Val-Ala
SC16.125-DL1 [182]
SC16.125
Delta-like protein 3 (DLL3)
SG2000 derivative PBD 1
Mal-PEG8-Val-Ala
SC16.126-DL1 [182]
SC16.126
Delta-like protein 3 (DLL3)
SG2000 derivative PBD 1
Mal-PEG8-Val-Ala
SC16.129-DL1 [182]
SC16.129
Delta-like protein 3 (DLL3)
SG2000 derivative PBD 1
Mal-PEG8-Val-Ala
SC16.130-DL1 [182]
SC16.130
Delta-like protein 3 (DLL3)
SG2000 derivative PBD 1
Mal-PEG8-Val-Ala
SC16.131-DL1 [182]
SC16.131
Delta-like protein 3 (DLL3)
SG2000 derivative PBD 1
Mal-PEG8-Val-Ala
SC16.132-DL1 [182]
SC16.132
Delta-like protein 3 (DLL3)
SG2000 derivative PBD 1
Mal-PEG8-Val-Ala
SC16.133-DL1 [182]
SC16.133
Delta-like protein 3 (DLL3)
SG2000 derivative PBD 1
Mal-PEG8-Val-Ala
SC16.134-DL1 [182]
SC16.134
Delta-like protein 3 (DLL3)
SG2000 derivative PBD 1
Mal-PEG8-Val-Ala
SC16.135-DL1 [182]
SC16.135
Delta-like protein 3 (DLL3)
SG2000 derivative PBD 1
Mal-PEG8-Val-Ala
SC16.136-DL1 [182]
SC16.136
Delta-like protein 3 (DLL3)
SG2000 derivative PBD 1
Mal-PEG8-Val-Ala
SC16.137-DL1 [182]
SC16.137
Delta-like protein 3 (DLL3)
SG2000 derivative PBD 1
Mal-PEG8-Val-Ala
SC16.138-DL1 [182]
SC16.138
Delta-like protein 3 (DLL3)
SG2000 derivative PBD 1
Mal-PEG8-Val-Ala
SC16.139-DL1 [182]
SC16.139
Delta-like protein 3 (DLL3)
SG2000 derivative PBD 1
Mal-PEG8-Val-Ala
SC16.140-DL1 [182]
SC16.140
Delta-like protein 3 (DLL3)
SG2000 derivative PBD 1
Mal-PEG8-Val-Ala
SC16.141-DL1 [182]
SC16.141
Delta-like protein 3 (DLL3)
SG2000 derivative PBD 1
Mal-PEG8-Val-Ala
SC16.142-DL1 [182]
SC16.142
Delta-like protein 3 (DLL3)
SG2000 derivative PBD 1
Mal-PEG8-Val-Ala
SC16.143-DL1 [182]
SC16.143
Delta-like protein 3 (DLL3)
SG2000 derivative PBD 1
Mal-PEG8-Val-Ala
SC16.144-DL1 [182]
SC16.144
Delta-like protein 3 (DLL3)
SG2000 derivative PBD 1
Mal-PEG8-Val-Ala
SC16.147-DL1 [182]
SC16.147
Delta-like protein 3 (DLL3)
SG2000 derivative PBD 1
Mal-PEG8-Val-Ala
SC16.148-DL1 [182]
SC16.148
Delta-like protein 3 (DLL3)
SG2000 derivative PBD 1
Mal-PEG8-Val-Ala
SC16.149-DL1 [182]
SC16.149
Delta-like protein 3 (DLL3)
SG2000 derivative PBD 1
Mal-PEG8-Val-Ala
SC16.150-DL1 [182]
SC16.150
Delta-like protein 3 (DLL3)
SG2000 derivative PBD 1
Mal-PEG8-Val-Ala
HuM25-vcMMAE-E2 [183]
HuM25
Leucine-rich repeat-containing protein 15 (LRRC15)
Monomethyl auristatin E
Mc-Val-Cit-PABC
HuM25-vcMMAE-DAR4 [183]
HuM25
Leucine-rich repeat-containing protein 15 (LRRC15)
Monomethyl auristatin E
Mc-Val-Cit-PABC
HuAD208.4.1-vcMMAE-DAR4 [183]
huAD208.4.1
Leucine-rich repeat-containing protein 15 (LRRC15)
Monomethyl auristatin E
Mc-Val-Cit-PABC
HuAD208.14.1-vcMMAE-DAR4 [183]
huAD208.14.1
Leucine-rich repeat-containing protein 15 (LRRC15)
Monomethyl auristatin E
Mc-Val-Cit-PABC
HuM25-mcMMAF-E2 [183]
HuM25
Leucine-rich repeat-containing protein 15 (LRRC15)
Monomethyl auristatin F
Maleimido-caproyl
NS Cys-vc-MMAE [184]
Undisclosed
Epidermal growth factor receptor (EGFR)
Monomethyl auristatin E
Mc-Val-Cit-PABC
Cetux Cys-vc-MMAE [184]
Glyco-engineered cetuximab
Epidermal growth factor receptor (EGFR)
Monomethyl auristatin E
Mc-Val-Cit-PABC
Glyco-cetuximab Fab-vc-MMAE [184]
Glyco-engineered cetuximab Fab
Epidermal growth factor receptor (EGFR)
Monomethyl auristatin E
Mc-Val-Cit-PABC
Cetux Fc/Fab-vc-MMAE [184]
Glyco-engineered cetuximab Fc/Fab
Epidermal growth factor receptor (EGFR)
Monomethyl auristatin E
Mc-Val-Cit-PABC
IC1-MMAE [185]
Chimeric ICAM1 Anti-ody (clone #R6.5)
Intercellular adhesion molecule 1 (ICAM1)
Monomethyl auristatin E
Mc-Val-Cit-PABC
IC1-MMAF [185]
Chimeric ICAM1 Anti-ody (clone #R6.5)
Intercellular adhesion molecule 1 (ICAM1)
Monomethyl auristatin F
Maleimido-caproyl
IC1-DM4 [185]
Chimeric ICAM1 Anti-ody (clone #R6.5)
Intercellular adhesion molecule 1 (ICAM1)
Mertansine DM4
Mal-EBE-Mal
IC1-DM1 [185]
Chimeric ICAM1 Anti-ody (clone #R6.5)
Intercellular adhesion molecule 1 (ICAM1)
Mertansine DM1
Mal-EBE-Mal
ADC Trast-7 [186]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
Undisclosed
ADC Trast-10 [186]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
Bis-BCN-modified Val-Cit-PABC linker 10
MMAE-IgG1 17 [187]
Anti-ENPP1 IgG1 17
Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 (ENPP1)
Monomethyl auristatin E
Undisclosed
MMAE-IgG1 3G12 [187]
Anti-ENPP1 IgG1 3G12
Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 (ENPP1)
Monomethyl auristatin E
Undisclosed
AB-3A4-Val-Cit-MMAE [188]
Anti-KAAG1 mAb AB-3A4
Kidney-associated antigen 1 (KAAG1)
Monomethyl auristatin E
Mc-Val-Cit-PABC
IGN-786 [189]
Anti-SAIL mAb
Translocator protein (TSPO)
Monomethyl auristatin F
Maleimido-caproyl
AVID-300 [190]
Panitumumab
Epidermal growth factor receptor (EGFR)
Mertansine DM1
Undisclosed
1711 (scFv)-SNAP-AuriF [191]
1711/425 scFv-SNAP
Epidermal growth factor receptor (EGFR)
Auristatin F
BG based linker
MMAE.VC.SA.617 [192]
Undisclosed
Glutamate carboxypeptidase 2 (FOLH1)
Monomethyl auristatin E
Undisclosed
CLDN1 ADC [193]
Anti-CLDN1 mAb 6F6
Claudin-1 (CLDN1)
Monomethyl auristatin E
Undisclosed
1959-sss/DM4 [194]
Undisclosed
Galectin-3-binding protein (LGALS3BP)
Mertansine DM4
Undisclosed
ZHER2-ABD-mcMMAF [195]
ZHER2-ABD
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin F
Maleimido-caproyl
ZHER2-ABD-mcMMAE [195]
ZHER2-ABD
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
Maleimido-caproyl
ITcetuximab [196]
Cetuximab
Epidermal growth factor receptor (EGFR)
Saporin
Undisclosed
Bevacizumab vedotin [197]
Bevacizumab
Vascular endothelial growth factor A (VEGFA)
Monomethyl auristatin E
Mc-Val-Cit-PABC
Anti-DOG1-DM4-ADC [198]
Anti-DOG1 mAb
Anoctamin-1 (ANO1)
Mertansine DM4
N-succinimidyl 4-(2-pyridyldithio) butanoate (SPDB)
A5/158-vc-MMAE [199]
A5/158
C-type mannose receptor 2 (MRC2)
Monomethyl auristatin E
Mc-Val-Cit-PABC
MesoADC [200]
Anti-GSDME mAb
Gasdermin-E (GSDME)
Monomethyl auristatin E
Mc-Val-Cit-PABC
3A5-mc-VC-PAB-MMAE [201]
Anti-MUC16 Anti-ody 3A5
Mucin-16 (MUC16)
Monomethyl auristatin E
Mc-Val-Cit-PABC
3A5-55 ADC [201]
Anti-MUC16 Anti-ody 3A5
Mucin-16 (MUC16)
Maytansine derivative 55
Mal-EBE-Mal
3A5-56 ADC [201]
Anti-MUC16 Anti-ody 3A5
Mucin-16 (MUC16)
Maytansine derivative 56
Mal-EBE-Mal
3A5-57 ADC [201]
Anti-MUC16 Anti-ody 3A5
Mucin-16 (MUC16)
Maytansine derivative 57
Maleimido-caproyl
MUC16-55 ADC [201]
Anti-MUC16 mAb
Mucin-16 (MUC16)
Maytansine derivative 55
Mal-EBE-Mal
MUC16-56 ADC [201]
Anti-MUC16 mAb
Mucin-16 (MUC16)
Maytansine derivative 56
Mal-EBE-Mal
Cys-linker-MMAE-based ADC 11 [202]
Mil40
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
Cys-11 ADC linker
Cys-linker-MMAE-based ADC 12 [202]
Mil40
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
Cys-12 ADC linker
Cys-linker-MMAE-based ADC 13 [202]
Mil40
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
Cys-13 ADC linker
Cys-linker-MMAE-based ADC 14 [202]
Mil40
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
Cys-14 ADC linker
Cys-linker-MMAE-based ADC 15 [202]
Mil40
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
Mc-PABC
Cys-linker-MMAE-based ADC 16 [202]
Mil40
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
Mc-Val-Cit-PABC
P38B-DM1 [203]
P38B
Podoplanin (PDPN)
Mertansine DM1
Azide-modified dibenzocyclooctyne(DBCO)-albumin(HAS)
GPC-1-ADC [204]
Anti-GPC1 mAb clone 01a033
Glypican-1 (GPC1)
Monomethyl auristatin F
Mc-Val-Cit-PABC
10D7-MMAE [205]
Anti-CDCP1 mAb 10D7
CUB domain-containing protein 1 (CDCP1)
Monomethyl auristatin E
Undisclosed
CD4-Val-Cit-MMAE [206]
Anti-CD4 mAb
T-cell surface glycoprotein CD4 (CD4)
Monomethyl auristatin E
Mc-Val-Cit-PABC
Trastuzumab-iCME [207]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Membrane-impermable colchinolmethyl ether (iCME) cytotoxin
Pacific blue fluorophore-SH based linker
2G10 RED-106 maytansine 2 [208]
Anti-PLAUR mAb 2G10
Urokinase plasminogen activator surface receptor (PLAUR)
Mertansine DM1
RED-106
2G10 RED-106 maytansine 4 [208]
Anti-PLAUR mAb 2G10
Urokinase plasminogen activator surface receptor (PLAUR)
Mertansine DM1
RED-106
2G10 RED-425 maytansine 4 [208]
Anti-PLAUR mAb 2G10
Urokinase plasminogen activator surface receptor (PLAUR)
Mertansine DM1
RED-425
2G10 RED-432 maytansine 4 [208]
Anti-PLAUR mAb 2G10
Urokinase plasminogen activator surface receptor (PLAUR)
Mertansine DM1
RED-432
2G10 RED-244 MMAE 2 [208]
Anti-PLAUR mAb 2G10
Urokinase plasminogen activator surface receptor (PLAUR)
Monomethyl auristatin E
RED-244
2G10 RED-244 MMAE 4 [208]
Anti-PLAUR mAb 2G10
Urokinase plasminogen activator surface receptor (PLAUR)
Monomethyl auristatin E
RED-244
2G10 RED-412 MMAE 4 [208]
Anti-PLAUR mAb 2G10
Urokinase plasminogen activator surface receptor (PLAUR)
Monomethyl auristatin E
RED-412
2G10 RED-388 MMAE 4 [208]
Anti-PLAUR mAb 2G10
Urokinase plasminogen activator surface receptor (PLAUR)
Monomethyl auristatin E
RED-388
2G10 RED-426 MMAE 4 [208]
Anti-PLAUR mAb 2G10
Urokinase plasminogen activator surface receptor (PLAUR)
Monomethyl auristatin E
RED-426
IgG1 (trastuzumab)-vc-MMAE [209]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
Mc-Val-Cit-PABC
IgG1 (H32)-vc-MMAE [209]
Anti-HER2 IgG1(H32)
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
Mc-Val-Cit-PABC
IgG1 (GH2-20)-vc-MMAE [209]
Anti-HER2 IgG1(GH2-20)
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
Mc-Val-Cit-PABC
IgG1 (GH2-61)-vc-MMAE [209]
Anti-HER2 IgG1(GH2-61)
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
Mc-Val-Cit-PABC
IgG1 (GH2-75)-vc-MMAE [209]
Anti-HER2 IgG1(GH2-75)
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
Mc-Val-Cit-PABC
Ch735-Py-DM1 [210]
Chimeric human mAb ch735
Oncodevelopmental antigen polysialic acid (polySia)
Mertansine DM1
TCO-PEG3-Mal
T-Py-DM1 [210]
Trastuzumab
Oncodevelopmental antigen polysialic acid (polySia)
Mertansine DM1
TCO-PEG3-Mal
IgG1 (trastuzumab)-AL1-MMAE [209]
Trastuzumab-AL1
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
Undisclosed
IgG1 (H32)-AL1-MMAE [209]
Anti-HER2 IgG1(H32)-AL1
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
Undisclosed
IgG1 (GH2-20)-AL1-MMAE [209]
Anti-HER2 IgG1(GH2-20)-AL1
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
Undisclosed
IgG1 (GH2-61)-AL1-MMAE [209]
Anti-HER2 IgG1(GH2-61)-AL1
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
Undisclosed
IgG1 (GH2-75)-AL1-MMAE [209]
Anti-HER2 IgG1(GH2-75)-AL1
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
Undisclosed
SNS-622-DM1 [211]
SNS-622
Aspartyl/asparaginyl beta-hydroxylase (ASPH)
Mertansine DM1
Maleimido-caproyl
SNS-622-MMAE [211]
SNS-622
Aspartyl/asparaginyl beta-hydroxylase (ASPH)
Monomethyl auristatin E
Mc-Val-Cit-PABC
DAB4-DM1 [212]
DAB4
Lupus La protein (SSB)
Mertansine DM1
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
DAB4-DM4 [212]
DAB4
Lupus La protein (SSB)
Mertansine DM4
N-succinimidyl 4-(2-pyridyldithio) butanoate (SPDB)
Sal5-DM4 [212]
Sal5
Epidermal growth factor receptor (EGFR); Receptor tyrosine-protein kinase erbB-3 (HER3)
Mertansine DM4
N-succinimidyl 4-(2-pyridyldithio) butanoate (SPDB)
DAB4-MMAE [212]
DAB4
Lupus La protein (SSB)
Monomethyl auristatin E
Mc-Val-Cit-PABC
Sal5-MMAE [212]
Sal5
Epidermal growth factor receptor (EGFR); Receptor tyrosine-protein kinase erbB-3 (HER3)
Monomethyl auristatin E
Mc-Val-Cit-PABC
DAB4-MMAF [212]
DAB4
Lupus La protein (SSB)
Monomethyl auristatin F
Mc-Val-Cit-PABC
89Zr-DFO-T-DM1 [213]
Zr-labeled trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Mertansine DM1
Undisclosed
Zt/g4-MMAE [214]
Anti-RON Zt/g4 (IgG1 kappa)
Macrophage-stimulating protein receptor (MST1R)
Monomethyl auristatin E
Mc-Val-Cit-PABC
Promiximab-MMAE [215]
Promiximab
Neural cell adhesion molecule 1 (NCAM1)
Monomethyl auristatin E
Mc-Val-Cit-PABC
EGFRvIII-16 [216]
Anti-EGFRvIII mAb
Epidermal growth factor receptor variant III (EGFRvIII)
DM1 derivative 16
Mc-Val-Cit-PABC
EGFRvIII-MCC-DM1 [216]
Anti-EGFRvIII mAb
Epidermal growth factor receptor variant III (EGFRvIII)
Mertansine DM1
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
PSMA-15 [216]
Anti-PSMA mAb
Glutamate carboxypeptidase 2 (FOLH1)
DM1 derivative 15
Mc-Val-Cit-PABC
PSMA-16 [216]
Anti-PSMA mAb
Glutamate carboxypeptidase 2 (FOLH1)
DM1 derivative 16
Mc-Val-Cit-PABC
PRLR-16 [216]
Anti-PRLR mAb
Prolactin receptor (PRLR)
DM1 derivative 16
Mc-Val-Cit-PABC
Trastuzumab/nab-paclitaxel [217]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Paclitaxel
Undisclosed
GPC-1 ADC 1 [218]
Anti-GPC1 mAb 01a033
Glypican-1 (GPC1)
Monomethyl auristatin F
Mc-Val-Cit-PABC
GPC-1 ADC 2 [218]
Anti-GPC1 mAb 01a002
Glypican-1 (GPC1)
Monomethyl auristatin F
Mc-Val-Cit-PABC
GPC-1 ADC 3 [218]
Anti-GPC1 mAb 02a035
Glypican-1 (GPC1)
Monomethyl auristatin F
Mc-Val-Cit-PABC
GPC-1 ADC 4 [218]
Anti-GPC1 mAb 02a034
Glypican-1 (GPC1)
Monomethyl auristatin F
Mc-Val-Cit-PABC
GPC-1 ADC 5 [218]
Anti-GPC1 mAb 02a014
Glypican-1 (GPC1)
Monomethyl auristatin F
Mc-Val-Cit-PABC
GPC-1 ADC 6 [218]
Anti-GPC1 mAb 02a002
Glypican-1 (GPC1)
Monomethyl auristatin F
Mc-Val-Cit-PABC
GPC-1 ADC 7 [218]
Anti-GPC1 mAb 02a010
Glypican-1 (GPC1)
Monomethyl auristatin F
Mc-Val-Cit-PABC
GPC-1 ADC 8 [218]
Anti-GPC1 mAb 01a016
Glypican-1 (GPC1)
Monomethyl auristatin F
Mc-Val-Cit-PABC
GPC-1 ADC 9 [218]
Anti-GPC1 mAb 02b006
Glypican-1 (GPC1)
Monomethyl auristatin F
Mc-Val-Cit-PABC
GPC-1 ADC 10 [218]
Anti-GPC1 mAb 01a021
Glypican-1 (GPC1)
Monomethyl auristatin F
Mc-Val-Cit-PABC
GPC-1 ADC 11 [218]
Anti-GPC1 mAb 02a022
Glypican-1 (GPC1)
Monomethyl auristatin F
Mc-Val-Cit-PABC
GPC-1 ADC 12 [218]
Anti-GPC1 mAb 01a009
Glypican-1 (GPC1)
Monomethyl auristatin F
Mc-Val-Cit-PABC
GPC-1 ADC 13 [218]
Anti-GPC1 mAb 01a030
Glypican-1 (GPC1)
Monomethyl auristatin F
Mc-Val-Cit-PABC
GPC-1 ADC 14 [218]
Anti-GPC1 mAb 01a017
Glypican-1 (GPC1)
Monomethyl auristatin F
Mc-Val-Cit-PABC
GPC-1 ADC 15 [218]
Anti-GPC1 mAb 01a007
Glypican-1 (GPC1)
Monomethyl auristatin F
Mc-Val-Cit-PABC
GPC-1 ADC 16 [218]
Anti-GPC1 mAb 01a042
Glypican-1 (GPC1)
Monomethyl auristatin F
Mc-Val-Cit-PABC
GPC-1 ADC 17 [218]
Anti-GPC1 mAb 01a026
Glypican-1 (GPC1)
Monomethyl auristatin F
Mc-Val-Cit-PABC
GPC-1 ADC 18 [218]
Anti-GPC1 mAb 02a006
Glypican-1 (GPC1)
Monomethyl auristatin F
Mc-Val-Cit-PABC
Docetaxel-trastuzumab [219]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Docetaxel
Undisclosed
M9346A-CX-DM1 [220]
Mirvetuximab
Folate receptor alpha (FOLR1)
Mertansine DM1
triglycyl peptide linker CX
M9346A-4a-Cxxx-Mal-CX-DM1 [220]
Mirvetuximab (engineered cysteine LC-C205)
Folate receptor alpha (FOLR1)
Mertansine DM1
Cxxx-Mal-CX
M9346A-4b-Cxxx-Mal-CX-DM1 [220]
Mirvetuximab (engineered cysteine LC-C400)
Folate receptor alpha (FOLR1)
Mertansine DM1
Cxxx-Mal-CX
M9346A-4c-Cxxx-Mal-CX-DM1 [220]
Mirvetuximab (engineered cysteine HC-C118)
Folate receptor alpha (FOLR1)
Mertansine DM1
Cxxx-Mal-CX
M9346A-4d-Cxxx-Mal-CX-DM1 [220]
Mirvetuximab (engineered cysteine HC-C239)
Folate receptor alpha (FOLR1)
Mertansine DM1
Cxxx-Mal-CX
HBU12-mc-MMAF [221]
Anti-CD19 mAb hBU12
B-lymphocyte antigen CD19 (CD19)
Monomethyl auristatin F
Mc-Val-Cit-PABC
CC2B-h15H3-gluc-MMAE [221]
Anti-ITGA5 mAb CC2B-h15H3
Integrin alpha-5 (ITGA5)
Monomethyl auristatin E
Quaternary ammonium linker Gluc
H15H3-gluc-MMAE [221]
Anti-ITGA5 mAb h15H3
Integrin alpha-5 (ITGA5)
Monomethyl auristatin E
Quaternary ammonium linker Gluc
HcHAb18-DM1 [222]
HcHAb18
Basigin (BSG)
Mertansine DM1
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
ChmAb-A B7-H3-ADC [223]
chmAb-A
CD276 antigen (CD276)
Monomethyl auristatin E
Mc-Val-Cit-PABC
ChmAb-B B7-H3-ADC [223]
chmAb-B
CD276 antigen (CD276)
Monomethyl auristatin E
Mc-Val-Cit-PABC
ChmAb-C B7-H3-ADC [223]
chmAb-C
CD276 antigen (CD276)
Monomethyl auristatin E
Mc-Val-Cit-PABC
ChmAb-D B7-H3-ADC [223]
chmAb-D
CD276 antigen (CD276)
Monomethyl auristatin E
Mc-Val-Cit-PABC
QD6/B09-AZ1508 [224]
QD6/B09
Epidermal growth factor receptor (EGFR); Hepatocyte growth factor receptor (MET)
QD6/B09-AZ1508
QD6/B09-AZ1508
RAA22/B09-AZ1508 [224]
RAA22/B09
Epidermal growth factor receptor (EGFR); Hepatocyte growth factor receptor (MET)
RAA22/B09-AZ1508
RAA22/B09-AZ1508
MuDS6-DM1 [225]
Anti-CA6 mAb muDS6
Mucin-1 (MUC1)
Mertansine DM1
N-succinimidyl 4-(2-pyridyldithio) pentanoate (SPP)
MuDS6-SSNPP-MM1-202 [225]
Anti-CA6 mAb muDS6
Mucin-1 (MUC1)
Mertansine DM1
Sulfosuccinimidyl-N-succinimidyl-4-(5-nitro-2-pyridyldithio) pentanoate (SSNPP)
HuDS6v1.01-DM4 [225]
huDS6v1.01
Mucin-1 (MUC1)
Mertansine DM4
N-succinimidyl 4-(2-pyridyldithio) butanoate (SPDB)
HuDS6v1.21-DM4 [225]
huDS6v1.21
Mucin-1 (MUC1)
Mertansine DM4
N-succinimidyl 4-(2-pyridyldithio) butanoate (SPDB)
28E4-DM1 [225]
280000
Mucin-1 (MUC1)
Mertansine DM1
N-succinimidyl 4-(2-pyridyldithio) pentanoate (SPP)
HAZcPB-DM1 [225]
HAZcPB
Mucin-1 (MUC1)
Mertansine DM1
N-succinimidyl 4-(2-pyridyldithio) pentanoate (SPP)
SSaPB-DM1 [225]
SSaPB
Mucin-1 (MUC1)
Mertansine DM1
N-succinimidyl 4-(2-pyridyldithio) pentanoate (SPP)
CNTO95-DM1 [226]
CNTO95
Integrin alpha-V (ITGAV)
Mertansine DM1
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
F105-DM1 [226]
F105
Integrin alpha-V (ITGAV)
Mertansine DM1
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
CNTO95-SPP-DM1 [226]
CNTO95
Integrin alpha-V (ITGAV)
Mertansine DM1
N-succinimidyl 4-(2-pyridyldithio) pentanoate (SPP)
F105-SPP-DM1 [226]
F105
Integrin alpha-V (ITGAV)
Mertansine DM1
N-succinimidyl 4-(2-pyridyldithio) pentanoate (SPP)
CNTO95-SSNPB-DM4 [226]
CNTO95
Integrin alpha-V (ITGAV)
Mertansine DM4
N-sulfosuccinimidyl-4-(5-nitro-2 pyridyldithio) butyrate (SSNPB)
F105-SSNPB-DM4 [226]
F105
Integrin alpha-V (ITGAV)
Mertansine DM4
N-sulfosuccinimidyl-4-(5-nitro-2 pyridyldithio) butyrate (SSNPB)
CNTO95-SSNPP-DM4 [226]
CNTO95
Integrin alpha-V (ITGAV)
Mertansine DM4
Sulfosuccinimidyl-N-succinimidyl-4-(5-nitro-2-pyridyldithio) pentanoate (SSNPP)
F105-SSNPP-DM4 [226]
F105
Integrin alpha-V (ITGAV)
Mertansine DM4
Sulfosuccinimidyl-N-succinimidyl-4-(5-nitro-2-pyridyldithio) pentanoate (SSNPP)
CNTO95-SPP-DM4 [226]
CNTO95
Integrin alpha-V (ITGAV)
Mertansine DM4
N-succinimidyl 4-(2-pyridyldithio) pentanoate (SPP)
F105-SPP-DM4 [226]
F105
Integrin alpha-V (ITGAV)
Mertansine DM4
N-succinimidyl 4-(2-pyridyldithio) pentanoate (SPP)
CNTO95-SPDB-DM4 [226]
CNTO95
Integrin alpha-V (ITGAV)
Mertansine DM4
N-succinimidyl 4-(2-pyridyldithio) butanoate (SPDB)
F105-SPDB-DM4 [226]
F105
Integrin alpha-V (ITGAV)
Mertansine DM4
N-succinimidyl 4-(2-pyridyldithio) butanoate (SPDB)
NBT062-SMCC-DM1 [1]
Indatuximab
Syndecan-1 (SDC1)
Mertansine DM1
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
NBT062-SPP-DM1 [1]
Indatuximab
Syndecan-1 (SDC1)
Mertansine DM1
N-succinimidyl 4-(2-pyridyldithio) pentanoate (SPP)
B-B4-SPP-DM1 [1]
Anti-CD138 mAb B-B4
Syndecan-1 (SDC1)
Mertansine DM1
N-succinimidyl 4-(2-pyridyldithio) pentanoate (SPP)
B-B4-SMCC-DM1 [1]
Anti-CD138 mAb B-B4
Syndecan-1 (SDC1)
Mertansine DM1
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
B-B4-SPDB-DM4 [1]
Anti-CD138 mAb B-B4
Syndecan-1 (SDC1)
Mertansine DM4
N-succinimidyl 4-(2-pyridyldithio) butanoate (SPDB)
HuMov19-PEG4-Mal-DM1 [227]
huMov19
Folate receptor alpha (FOLR1)
Mertansine DM1
PEG4-Mal
FR1-21-PEG4-Mal-DM1 [227]
FR1-21
Folate receptor alpha (FOLR1)
Mertansine DM1
PEG4-Mal
Mov19-PEG4-Mal-DM1 [227]
Mov19
Folate receptor alpha (FOLR1)
Mertansine DM1
PEG4-Mal
Farletuzumab-PEG4-Mal-DM1 [227]
Farletuzumab
Folate receptor alpha (FOLR1)
Mertansine DM1
PEG4-Mal
FR1-48-PEG4-Mal-DM1 [227]
FR1-48
Folate receptor alpha (FOLR1)
Mertansine DM1
PEG4-Mal
FR1-49-PEG4-Mal-DM1 [227]
FR1-49
Folate receptor alpha (FOLR1)
Mertansine DM1
PEG4-Mal
FR1-57-PEG4-Mal-DM1 [227]
FR1-57
Folate receptor alpha (FOLR1)
Mertansine DM1
PEG4-Mal
FR1-65-PEG4-Mal-DM1 [227]
FR1-65
Folate receptor alpha (FOLR1)
Mertansine DM1
PEG4-Mal
HuMOV19v1.6-PEG4-Mal-DM1 [227]
huMOV19v1.6
Folate receptor alpha (FOLR1)
Mertansine DM1
PEG4-Mal
HuMOV19v1.0-PEG4-Mal-DM1 [227]
huMOV19v1.0
Folate receptor alpha (FOLR1)
Mertansine DM1
PEG4-Mal
HuFR1-21-PEG4-Mal-DM1 [227]
huFR1-21
Folate receptor alpha (FOLR1)
Mertansine DM1
PEG4-Mal
MuFR1-21-PEG4-Mal-DM1 [227]
mu-FR1-21
Folate receptor alpha (FOLR1)
Mertansine DM1
PEG4-Mal
MuFR1-9-PEG4-Mal-DM1 [227]
mu-FR1-9
Folate receptor alpha (FOLR1)
Mertansine DM1
PEG4-Mal
MuFR1-13-PEG4-Mal-DM1 [227]
mu-FR1-13
Folate receptor alpha (FOLR1)
Mertansine DM1
PEG4-Mal
MuFR1-22-PEG4-Mal-DM1 [227]
mu-FR1-22
Folate receptor alpha (FOLR1)
Mertansine DM1
PEG4-Mal
MuFR1-23-PEG4-Mal-DM1 [227]
mu-FR1-23
Folate receptor alpha (FOLR1)
Mertansine DM1
PEG4-Mal
HuFR1-23-PEG4-Mal-DM1 [227]
huFR1-23
Folate receptor alpha (FOLR1)
Mertansine DM1
PEG4-Mal
HuMov19-SMCC-DM1 [227]
huMov19
Folate receptor alpha (FOLR1)
Mertansine DM1
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
FR1-21-SMCC-DM1 [227]
FR1-21
Folate receptor alpha (FOLR1)
Mertansine DM1
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
Mov19-SMCC-DM1 [227]
Mov19
Folate receptor alpha (FOLR1)
Mertansine DM1
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
Farletuzumab-SMCC-DM1 [227]
Farletuzumab
Folate receptor alpha (FOLR1)
Mertansine DM1
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
FR1-48-SMCC-DM1 [227]
FR1-48
Folate receptor alpha (FOLR1)
Mertansine DM1
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
FR1-49-SMCC-DM1 [227]
FR1-49
Folate receptor alpha (FOLR1)
Mertansine DM1
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
FR1-57-SMCC-DM1 [227]
FR1-57
Folate receptor alpha (FOLR1)
Mertansine DM1
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
FR1-65-SMCC-DM1 [227]
FR1-65
Folate receptor alpha (FOLR1)
Mertansine DM1
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
HuMOV19v1.6-SMCC-DM1 [227]
huMOV19v1.6
Folate receptor alpha (FOLR1)
Mertansine DM1
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
HuMOV19v1.0-SMCC-DM1 [227]
huMOV19v1.0
Folate receptor alpha (FOLR1)
Mertansine DM1
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
HuFR1-21-SMCC-DM1 [227]
huFR1-21
Folate receptor alpha (FOLR1)
Mertansine DM1
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
MuFR1-21-SMCC-DM1 [227]
mu-FR1-21
Folate receptor alpha (FOLR1)
Mertansine DM1
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
MuFR1-9-SMCC-DM1 [227]
mu-FR1-9
Folate receptor alpha (FOLR1)
Mertansine DM1
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
MuFR1-13-SMCC-DM1 [227]
mu-FR1-13
Folate receptor alpha (FOLR1)
Mertansine DM1
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
MuFR1-22-SMCC-DM1 [227]
mu-FR1-22
Folate receptor alpha (FOLR1)
Mertansine DM1
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
MuFR1-23-SMCC-DM1 [227]
mu-FR1-23
Folate receptor alpha (FOLR1)
Mertansine DM1
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
HuFR1-23-SMCC-DM1 [227]
huFR1-23
Folate receptor alpha (FOLR1)
Mertansine DM1
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
HuMov19-SIA-DM1 [227]
huMov19
Folate receptor alpha (FOLR1)
Mertansine DM1
N-succinimidyl iodoacetate (SIA)
FR1-21-SIA-DM1 [227]
FR1-21
Folate receptor alpha (FOLR1)
Mertansine DM1
N-succinimidyl iodoacetate (SIA)
Mov19-SIA-DM1 [227]
Mov19
Folate receptor alpha (FOLR1)
Mertansine DM1
N-succinimidyl iodoacetate (SIA)
Farletuzumab-SIA-DM1 [227]
Farletuzumab
Folate receptor alpha (FOLR1)
Mertansine DM1
N-succinimidyl iodoacetate (SIA)
FR1-48-SIA-DM1 [227]
FR1-48
Folate receptor alpha (FOLR1)
Mertansine DM1
N-succinimidyl iodoacetate (SIA)
FR1-49-SIA-DM1 [227]
FR1-49
Folate receptor alpha (FOLR1)
Mertansine DM1
N-succinimidyl iodoacetate (SIA)
FR1-57-SIA-DM1 [227]
FR1-57
Folate receptor alpha (FOLR1)
Mertansine DM1
N-succinimidyl iodoacetate (SIA)
FR1-65-SIA-DM1 [227]
FR1-65
Folate receptor alpha (FOLR1)
Mertansine DM1
N-succinimidyl iodoacetate (SIA)
HuMOV19v1.6-SIA-DM1 [227]
huMOV19v1.6
Folate receptor alpha (FOLR1)
Mertansine DM1
N-succinimidyl iodoacetate (SIA)
HuMOV19v1.0-SIA-DM1 [227]
huMOV19v1.0
Folate receptor alpha (FOLR1)
Mertansine DM1
N-succinimidyl iodoacetate (SIA)
HuFR1-21-SIA-DM1 [227]
huFR1-21
Folate receptor alpha (FOLR1)
Mertansine DM1
N-succinimidyl iodoacetate (SIA)
MuFR1-21-SIA-DM1 [227]
mu-FR1-21
Folate receptor alpha (FOLR1)
Mertansine DM1
N-succinimidyl iodoacetate (SIA)
MuFR1-9-SIA-DM1 [227]
mu-FR1-9
Folate receptor alpha (FOLR1)
Mertansine DM1
N-succinimidyl iodoacetate (SIA)
MuFR1-13-SIA-DM1 [227]
mu-FR1-13
Folate receptor alpha (FOLR1)
Mertansine DM1
N-succinimidyl iodoacetate (SIA)
MuFR1-22-SIA-DM1 [227]
mu-FR1-22
Folate receptor alpha (FOLR1)
Mertansine DM1
N-succinimidyl iodoacetate (SIA)
MuFR1-23-SIA-DM1 [227]
mu-FR1-23
Folate receptor alpha (FOLR1)
Mertansine DM1
N-succinimidyl iodoacetate (SIA)
HuFR1-23-SIA-DM1 [227]
huFR1-23
Folate receptor alpha (FOLR1)
Mertansine DM1
N-succinimidyl iodoacetate (SIA)
HuMov19-SPP-DM1 [227]
huMov19
Folate receptor alpha (FOLR1)
Mertansine DM1
N-succinimidyl 4-(2-pyridyldithio) pentanoate (SPP)
FR1-21-SPP-DM1 [227]
FR1-21
Folate receptor alpha (FOLR1)
Mertansine DM1
N-succinimidyl 4-(2-pyridyldithio) pentanoate (SPP)
Mov19-SPP-DM1 [227]
Mov19
Folate receptor alpha (FOLR1)
Mertansine DM1
N-succinimidyl 4-(2-pyridyldithio) pentanoate (SPP)
Farletuzumab-SPP-DM1 [227]
Farletuzumab
Folate receptor alpha (FOLR1)
Mertansine DM1
N-succinimidyl 4-(2-pyridyldithio) pentanoate (SPP)
FR1-48-SPP-DM1 [227]
FR1-48
Folate receptor alpha (FOLR1)
Mertansine DM1
N-succinimidyl 4-(2-pyridyldithio) pentanoate (SPP)
FR1-49-SPP-DM1 [227]
FR1-49
Folate receptor alpha (FOLR1)
Mertansine DM1
N-succinimidyl 4-(2-pyridyldithio) pentanoate (SPP)
FR1-57-SPP-DM1 [227]
FR1-57
Folate receptor alpha (FOLR1)
Mertansine DM1
N-succinimidyl 4-(2-pyridyldithio) pentanoate (SPP)
FR1-65-SPP-DM1 [227]
FR1-65
Folate receptor alpha (FOLR1)
Mertansine DM1
N-succinimidyl 4-(2-pyridyldithio) pentanoate (SPP)
HuMOV19v1.6-SPP-DM1 [227]
huMOV19v1.6
Folate receptor alpha (FOLR1)
Mertansine DM1
N-succinimidyl 4-(2-pyridyldithio) pentanoate (SPP)
HuMOV19v1.0-SPP-DM1 [227]
huMOV19v1.0
Folate receptor alpha (FOLR1)
Mertansine DM1
N-succinimidyl 4-(2-pyridyldithio) pentanoate (SPP)
HuFR1-21-SPP-DM1 [227]
huFR1-21
Folate receptor alpha (FOLR1)
Mertansine DM1
N-succinimidyl 4-(2-pyridyldithio) pentanoate (SPP)
MuFR1-21-SPP-DM1 [227]
mu-FR1-21
Folate receptor alpha (FOLR1)
Mertansine DM1
N-succinimidyl 4-(2-pyridyldithio) pentanoate (SPP)
MuFR1-9-SPP-DM1 [227]
mu-FR1-9
Folate receptor alpha (FOLR1)
Mertansine DM1
N-succinimidyl 4-(2-pyridyldithio) pentanoate (SPP)
MuFR1-13-SPP-DM1 [227]
mu-FR1-13
Folate receptor alpha (FOLR1)
Mertansine DM1
N-succinimidyl 4-(2-pyridyldithio) pentanoate (SPP)
MuFR1-22-SPP-DM1 [227]
mu-FR1-22
Folate receptor alpha (FOLR1)
Mertansine DM1
N-succinimidyl 4-(2-pyridyldithio) pentanoate (SPP)
MuFR1-23-SPP-DM1 [227]
mu-FR1-23
Folate receptor alpha (FOLR1)
Mertansine DM1
N-succinimidyl 4-(2-pyridyldithio) pentanoate (SPP)
HuFR1-23-SPP-DM1 [227]
huFR1-23
Folate receptor alpha (FOLR1)
Mertansine DM1
N-succinimidyl 4-(2-pyridyldithio) pentanoate (SPP)
HuMov19-sulfo-SPDB-DM4 (DAR3.8) [227]
huMov19
Folate receptor alpha (FOLR1)
Mertansine DM4
Sulfo-SPDB
FR1-21-sulfo-SPDB-DM4 [227]
FR1-21
Folate receptor alpha (FOLR1)
Mertansine DM4
Sulfo-SPDB
Mov19-sulfo-SPDB-DM4 [227]
Mov19
Folate receptor alpha (FOLR1)
Mertansine DM4
Sulfo-SPDB
Farletuzumab-sulfo-SPDB-DM4 [227]
Farletuzumab
Folate receptor alpha (FOLR1)
Mertansine DM4
Sulfo-SPDB
FR1-48-sulfo-SPDB-DM4 [227]
FR1-48
Folate receptor alpha (FOLR1)
Mertansine DM4
Sulfo-SPDB
FR1-49-sulfo-SPDB-DM4 [227]
FR1-49
Folate receptor alpha (FOLR1)
Mertansine DM4
Sulfo-SPDB
FR1-57-sulfo-SPDB-DM4 [227]
FR1-57
Folate receptor alpha (FOLR1)
Mertansine DM4
Sulfo-SPDB
FR1-65-sulfo-SPDB-DM4 [227]
FR1-65
Folate receptor alpha (FOLR1)
Mertansine DM4
Sulfo-SPDB
HuMOV19v1.6-sulfo-SPDB-DM4 [227]
huMOV19v1.6
Folate receptor alpha (FOLR1)
Mertansine DM4
Sulfo-SPDB
HuMOV19v1.0-sulfo-SPDB-DM4 [227]
huMOV19v1.0
Folate receptor alpha (FOLR1)
Mertansine DM4
Sulfo-SPDB
HuFR1-21-sulfo-SPDB-DM4 [227]
huFR1-21
Folate receptor alpha (FOLR1)
Mertansine DM4
Sulfo-SPDB
MuFR1-21-sulfo-SPDB-DM4 [227]
mu-FR1-21
Folate receptor alpha (FOLR1)
Mertansine DM4
Sulfo-SPDB
MuFR1-9-sulfo-SPDB-DM4 [227]
mu-FR1-9
Folate receptor alpha (FOLR1)
Mertansine DM4
Sulfo-SPDB
MuFR1-13-sulfo-SPDB-DM4 [227]
mu-FR1-13
Folate receptor alpha (FOLR1)
Mertansine DM4
Sulfo-SPDB
MuFR1-22-sulfo-SPDB-DM4 [227]
mu-FR1-22
Folate receptor alpha (FOLR1)
Mertansine DM4
Sulfo-SPDB
MuFR1-23-sulfo-SPDB-DM4 [227]
mu-FR1-23
Folate receptor alpha (FOLR1)
Mertansine DM4
Sulfo-SPDB
HuFR1-23-sulfo-SPDB-DM4 [227]
huFR1-23
Folate receptor alpha (FOLR1)
Mertansine DM4
Sulfo-SPDB
HuMov19-SPDB-DM4 [227]
huMov19
Folate receptor alpha (FOLR1)
Mertansine DM4
N-succinimidyl 4-(2-pyridyldithio) butanoate (SPDB)
FR1-21-SPDB-DM4 [227]
FR1-21
Folate receptor alpha (FOLR1)
Mertansine DM4
N-succinimidyl 4-(2-pyridyldithio) butanoate (SPDB)
Mov19-SPDB-DM4 [227]
Mov19
Folate receptor alpha (FOLR1)
Mertansine DM4
N-succinimidyl 4-(2-pyridyldithio) butanoate (SPDB)
Farletuzumab-SPDB-DM4 [227]
Farletuzumab
Folate receptor alpha (FOLR1)
Mertansine DM4
N-succinimidyl 4-(2-pyridyldithio) butanoate (SPDB)
FR1-48-SPDB-DM4 [227]
FR1-48
Folate receptor alpha (FOLR1)
Mertansine DM4
N-succinimidyl 4-(2-pyridyldithio) butanoate (SPDB)
FR1-49-SPDB-DM4 [227]
FR1-49
Folate receptor alpha (FOLR1)
Mertansine DM4
N-succinimidyl 4-(2-pyridyldithio) butanoate (SPDB)
FR1-57-SPDB-DM4 [227]
FR1-57
Folate receptor alpha (FOLR1)
Mertansine DM4
N-succinimidyl 4-(2-pyridyldithio) butanoate (SPDB)
FR1-65-SPDB-DM4 [227]
FR1-65
Folate receptor alpha (FOLR1)
Mertansine DM4
N-succinimidyl 4-(2-pyridyldithio) butanoate (SPDB)
HuMOV19v1.6-SPDB-DM4 [227]
huMOV19v1.6
Folate receptor alpha (FOLR1)
Mertansine DM4
N-succinimidyl 4-(2-pyridyldithio) butanoate (SPDB)
HuMOV19v1.0-SPDB-DM4 [227]
huMOV19v1.0
Folate receptor alpha (FOLR1)
Mertansine DM4
N-succinimidyl 4-(2-pyridyldithio) butanoate (SPDB)
HuFR1-21-SPDB-DM4 [227]
huFR1-21
Folate receptor alpha (FOLR1)
Mertansine DM4
N-succinimidyl 4-(2-pyridyldithio) butanoate (SPDB)
MuFR1-21-SPDB-DM4 [227]
mu-FR1-21
Folate receptor alpha (FOLR1)
Mertansine DM4
N-succinimidyl 4-(2-pyridyldithio) butanoate (SPDB)
MuFR1-9-SPDB-DM4 [227]
mu-FR1-9
Folate receptor alpha (FOLR1)
Mertansine DM4
N-succinimidyl 4-(2-pyridyldithio) butanoate (SPDB)
MuFR1-13-SPDB-DM4 [227]
mu-FR1-13
Folate receptor alpha (FOLR1)
Mertansine DM4
N-succinimidyl 4-(2-pyridyldithio) butanoate (SPDB)
MuFR1-22-SPDB-DM4 [227]
mu-FR1-22
Folate receptor alpha (FOLR1)
Mertansine DM4
N-succinimidyl 4-(2-pyridyldithio) butanoate (SPDB)
MuFR1-23-SPDB-DM4 [227]
mu-FR1-23
Folate receptor alpha (FOLR1)
Mertansine DM4
N-succinimidyl 4-(2-pyridyldithio) butanoate (SPDB)
HuFR1-23-SPDB-DM4 [227]
huFR1-23
Folate receptor alpha (FOLR1)
Mertansine DM4
N-succinimidyl 4-(2-pyridyldithio) butanoate (SPDB)
HuMov19-3-sulfo-Mal-DM4 (DAR 3.7) [227]
huMov19
Folate receptor alpha (FOLR1)
Mertansine DM4
3-sulfo-Mal
FR1-21-3-sulfo-Mal-DM4 [227]
FR1-21
Folate receptor alpha (FOLR1)
Mertansine DM4
3-sulfo-Mal
Mov19-3-sulfo-Mal-DM4 [227]
Mov19
Folate receptor alpha (FOLR1)
Mertansine DM4
3-sulfo-Mal
Farletuzumab-3-sulfo-Mal-DM4 [227]
Farletuzumab
Folate receptor alpha (FOLR1)
Mertansine DM4
3-sulfo-Mal
FR1-48-3-sulfo-Mal-DM4 [227]
FR1-48
Folate receptor alpha (FOLR1)
Mertansine DM4
3-sulfo-Mal
FR1-49-3-sulfo-Mal-DM4 [227]
FR1-49
Folate receptor alpha (FOLR1)
Mertansine DM4
3-sulfo-Mal
FR1-57-3-sulfo-Mal-DM4 [227]
FR1-57
Folate receptor alpha (FOLR1)
Mertansine DM4
3-sulfo-Mal
FR1-65-3-sulfo-Mal-DM4 [227]
FR1-65
Folate receptor alpha (FOLR1)
Mertansine DM4
3-sulfo-Mal
HuMOV19v1.6-3-sulfo-Mal-DM4 [227]
huMOV19v1.6
Folate receptor alpha (FOLR1)
Mertansine DM4
3-sulfo-Mal
HuMOV19v1.0-3-sulfo-Mal-DM4 [227]
huMOV19v1.0
Folate receptor alpha (FOLR1)
Mertansine DM4
3-sulfo-Mal
HuFR1-21-3-sulfo-Mal-DM4 [227]
huFR1-21
Folate receptor alpha (FOLR1)
Mertansine DM4
3-sulfo-Mal
MuFR1-21-3-sulfo-Mal-DM4 [227]
mu-FR1-21
Folate receptor alpha (FOLR1)
Mertansine DM4
3-sulfo-Mal
MuFR1-9-3-sulfo-Mal-DM4 [227]
mu-FR1-9
Folate receptor alpha (FOLR1)
Mertansine DM4
3-sulfo-Mal
MuFR1-13-3-sulfo-Mal-DM4 [227]
mu-FR1-13
Folate receptor alpha (FOLR1)
Mertansine DM4
3-sulfo-Mal
MuFR1-22-3-sulfo-Mal-DM4 [227]
mu-FR1-22
Folate receptor alpha (FOLR1)
Mertansine DM4
3-sulfo-Mal
MuFR1-23-3-sulfo-Mal-DM4 [227]
mu-FR1-23
Folate receptor alpha (FOLR1)
Mertansine DM4
3-sulfo-Mal
HuFR1-23-3-sulfo-Mal-DM4 [227]
huFR1-23
Folate receptor alpha (FOLR1)
Mertansine DM4
3-sulfo-Mal
HuMov19-PEG4-Mal-DM4 [227]
huMov19
Folate receptor alpha (FOLR1)
Mertansine DM4
PEG4-Mal
FR1-21-PEG4-Mal-DM4 [227]
FR1-21
Folate receptor alpha (FOLR1)
Mertansine DM4
PEG4-Mal
Mov19-PEG4-Mal-DM4 [227]
Mov19
Folate receptor alpha (FOLR1)
Mertansine DM4
PEG4-Mal
Farletuzumab-PEG4-Mal-DM4 [227]
Farletuzumab
Folate receptor alpha (FOLR1)
Mertansine DM4
PEG4-Mal
FR1-48-PEG4-Mal-DM4 [227]
FR1-48
Folate receptor alpha (FOLR1)
Mertansine DM4
PEG4-Mal
FR1-49-PEG4-Mal-DM4 [227]
FR1-49
Folate receptor alpha (FOLR1)
Mertansine DM4
PEG4-Mal
FR1-57-PEG4-Mal-DM4 [227]
FR1-57
Folate receptor alpha (FOLR1)
Mertansine DM4
PEG4-Mal
FR1-65-PEG4-Mal-DM4 [227]
FR1-65
Folate receptor alpha (FOLR1)
Mertansine DM4
PEG4-Mal
HuMOV19v1.6-PEG4-Mal-DM4 [227]
huMOV19v1.6
Folate receptor alpha (FOLR1)
Mertansine DM4
PEG4-Mal
HuMOV19v1.0-PEG4-Mal-DM4 [227]
huMOV19v1.0
Folate receptor alpha (FOLR1)
Mertansine DM4
PEG4-Mal
HuFR1-21-PEG4-Mal-DM4 [227]
huFR1-21
Folate receptor alpha (FOLR1)
Mertansine DM4
PEG4-Mal
MuFR1-21-PEG4-Mal-DM4 [227]
mu-FR1-21
Folate receptor alpha (FOLR1)
Mertansine DM4
PEG4-Mal
MuFR1-9-PEG4-Mal-DM4 [227]
mu-FR1-9
Folate receptor alpha (FOLR1)
Mertansine DM4
PEG4-Mal
MuFR1-13-PEG4-Mal-DM4 [227]
mu-FR1-13
Folate receptor alpha (FOLR1)
Mertansine DM4
PEG4-Mal
MuFR1-22-PEG4-Mal-DM4 [227]
mu-FR1-22
Folate receptor alpha (FOLR1)
Mertansine DM4
PEG4-Mal
MuFR1-23-PEG4-Mal-DM4 [227]
mu-FR1-23
Folate receptor alpha (FOLR1)
Mertansine DM4
PEG4-Mal
HuFR1-23-PEG4-Mal-DM4 [227]
huFR1-23
Folate receptor alpha (FOLR1)
Mertansine DM4
PEG4-Mal
HuMov19-3-sulfo-Mal-DM4 (DAR 8.23) [227]
huMov19
Folate receptor alpha (FOLR1)
Mertansine DM4
3-sulfo-Mal
HuMov19-sulfo-SPDB-DM4 (DAR6.8) [227]
huMov19
Folate receptor alpha (FOLR1)
Mertansine DM4
Sulfo-SPDB
M9346A-SMCC-DM1 [227]
Mirvetuximab
Folate receptor alpha (FOLR1)
Mertansine DM1
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
M9346A-SPP-DM1 [227]
Mirvetuximab
Folate receptor alpha (FOLR1)
Mertansine DM1
N-succinimidyl 4-(2-pyridyldithio) pentanoate (SPP)
M9346A-sulfo-Mal-DM4 [227]
Mirvetuximab
Folate receptor alpha (FOLR1)
Mertansine DM4
3-sulfo-Mal
M9346A-SPDB-DM4 [227]
Mirvetuximab
Folate receptor alpha (FOLR1)
Mertansine DM4
N-succinimidyl 4-(2-pyridyldithio) butanoate (SPDB)
1C1-mcMMAF [228]
Anti-EPHA2 mAb 1C1
Ephrin type-A receptor 2 (EPHA2)
Monomethyl auristatin F
Maleimido-caproyl
LCB14-0648 [229]
Anti-CD19 mAb DI-B4
B-lymphocyte antigen CD19 (CD19)
Monomethyl auristatin F
LCB14-0648 linker
LCB14-0663 [229]
Anti-CD19 mAb DI-B4
B-lymphocyte antigen CD19 (CD19)
Monomethyl auristatin F
LCB14-0663 linker
LCB14-0664 [229]
Anti-CD19 mAb DI-B4
B-lymphocyte antigen CD19 (CD19)
Monomethyl auristatin F
LCB14-0664 linker
LCB14-6e [229]
Anti-CD19 mAb DI-B4
B-lymphocyte antigen CD19 (CD19)
Monomethyl auristatin E
LCB14-6e linker
Anti-CD19(LC)-G7VIM-2i [229]
DI-B4-(LC)-GGGGGGG-CVIM
B-lymphocyte antigen CD19 (CD19)
Monomethyl auristatin F
Anti-CD19(LC)-G7VIM-2i linker
Blinatumomab-2i [229]
Blinatumomab
B-lymphocyte antigen CD19 (CD19); T-cell surface glycoprotein CD3 delta chain (CD3D)
Monomethyl auristatin F
Blinatumomab-2i linker
Inebilizumab-2i [229]
Inebilizumab
B-lymphocyte antigen CD19 (CD19)
Monomethyl auristatin F
Inebilizumab-2i linker
Tafasitamab-2i [229]
Tafasitamab
B-lymphocyte antigen CD19 (CD19)
Monomethyl auristatin F
Tafasitamab-2i linker
Obexelimab-2i [229]
Obexelimab
B-lymphocyte antigen CD19 (CD19)
Monomethyl auristatin F
Obexelimab-2i linker
MDX-1342-2i [229]
MDX-1342
B-lymphocyte antigen CD19 (CD19)
Monomethyl auristatin F
MDX-1342-2i linker
MDX-1435-2i [229]
MDX-1435
B-lymphocyte antigen CD19 (CD19)
Monomethyl auristatin F
MDX-1435-2i linker
CHD37-2i [229]
cHD37
B-lymphocyte antigen CD19 (CD19)
Monomethyl auristatin F
cHD37-2i linker
AFM-11-2i [229]
AFM-11
B-lymphocyte antigen CD19 (CD19)
Monomethyl auristatin F
AFM-11-2i linker
AFM-12-2i [229]
AFM-12
B-lymphocyte antigen CD19 (CD19)
Monomethyl auristatin F
AFM-12-2i linker
GBR401-2i [229]
GBR401
B-lymphocyte antigen CD19 (CD19)
Monomethyl auristatin F
GBR401-2i linker
Denintuzumab-2i [229]
Denintuzumab
B-lymphocyte antigen CD19 (CD19)
Monomethyl auristatin F
Denintuzumab-2i linker
Anti-CD19(LC)-G7VIM-4i [229]
DI-B4-(LC)-GGGGGGG-CVIM
B-lymphocyte antigen CD19 (CD19)
Monomethyl auristatin F
Anti-CD19(LC)-G7VIM-4i linker
Blinatumomab-4i [229]
Blinatumomab
B-lymphocyte antigen CD19 (CD19); T-cell surface glycoprotein CD3 delta chain (CD3D)
Monomethyl auristatin F
Blinatumomab-4i linker
Inebilizumab-4i [229]
Inebilizumab
B-lymphocyte antigen CD19 (CD19)
Monomethyl auristatin F
Inebilizumab-4i linker
Tafasitamab-4i [229]
Tafasitamab
B-lymphocyte antigen CD19 (CD19)
Monomethyl auristatin F
Tafasitamab-4i linker
Obexelimab-4i [229]
Obexelimab
B-lymphocyte antigen CD19 (CD19)
Monomethyl auristatin F
Obexelimab-4i linker
MDX-1342-4i [229]
MDX-1342
B-lymphocyte antigen CD19 (CD19)
Monomethyl auristatin F
MDX-1342-4i linker
MDX-1435-4i [229]
MDX-1435
B-lymphocyte antigen CD19 (CD19)
Monomethyl auristatin F
MDX-1435-4i linker
CHD37-4i [229]
cHD37
B-lymphocyte antigen CD19 (CD19)
Monomethyl auristatin F
cHD37-4i linker
AFM-11-4i [229]
AFM-11
B-lymphocyte antigen CD19 (CD19)
Monomethyl auristatin F
AFM-11-4i linker
AFM-12-4i [229]
AFM-12
B-lymphocyte antigen CD19 (CD19)
Monomethyl auristatin F
AFM-12-4i linker
GBR401-4i [229]
GBR401
B-lymphocyte antigen CD19 (CD19)
Monomethyl auristatin F
GBR401-4i linker
Denintuzumab-4i [229]
Denintuzumab
B-lymphocyte antigen CD19 (CD19)
Monomethyl auristatin F
Denintuzumab-4i linker
Anti-CD19(LC)-G7VIM-3i [229]
DI-B4-(LC)-GGGGGGG-CVIM
B-lymphocyte antigen CD19 (CD19)
Monomethyl auristatin F
Anti-CD19(LC)-G7VIM-3i linker
Blinatumomab-3i [229]
Blinatumomab
B-lymphocyte antigen CD19 (CD19); T-cell surface glycoprotein CD3 delta chain (CD3D)
Monomethyl auristatin F
Blinatumomab-3i linker
Inebilizumab-3i [229]
Inebilizumab
B-lymphocyte antigen CD19 (CD19)
Monomethyl auristatin F
Inebilizumab-3i linker
Tafasitamab-3i [229]
Tafasitamab
B-lymphocyte antigen CD19 (CD19)
Monomethyl auristatin F
Tafasitamab-3i linker
Obexelimab-3i [229]
Obexelimab
B-lymphocyte antigen CD19 (CD19)
Monomethyl auristatin F
Obexelimab-3i linker
MDX-1342-3i [229]
MDX-1342
B-lymphocyte antigen CD19 (CD19)
Monomethyl auristatin F
MDX-1342-3i linker
MDX-1435-3i [229]
MDX-1435
B-lymphocyte antigen CD19 (CD19)
Monomethyl auristatin F
MDX-1435-3i linker
CHD37-3i [229]
cHD37
B-lymphocyte antigen CD19 (CD19)
Monomethyl auristatin F
cHD37-3i linker
AFM-11-3i [229]
AFM-11
B-lymphocyte antigen CD19 (CD19)
Monomethyl auristatin F
AFM-11-3i linker
AFM-12-3i [229]
AFM-12
B-lymphocyte antigen CD19 (CD19)
Monomethyl auristatin F
AFM-12-3i linker
GBR401-3i [229]
GBR401
B-lymphocyte antigen CD19 (CD19)
Monomethyl auristatin F
GBR401-3i linker
Denintuzumab-3i [229]
Denintuzumab
B-lymphocyte antigen CD19 (CD19)
Monomethyl auristatin F
Denintuzumab-3i linker
Anti-CD19(LC)-G7VIM-6e [229]
DI-B4-(LC)-GGGGGGG-CVIM
B-lymphocyte antigen CD19 (CD19)
Monomethyl auristatin E
Anti-CD19(LC)-G7VIM-6e linker
Blinatumomab-6e [229]
Blinatumomab
B-lymphocyte antigen CD19 (CD19); T-cell surface glycoprotein CD3 delta chain (CD3D)
Monomethyl auristatin E
Blinatumomab-6e linker
Inebilizumab-6e [229]
Inebilizumab
B-lymphocyte antigen CD19 (CD19)
Monomethyl auristatin E
Inebilizumab-6e linker
Tafasitamab-6e [229]
Tafasitamab
B-lymphocyte antigen CD19 (CD19)
Monomethyl auristatin E
Tafasitamab-6e linker
Obexelimab-6e [229]
Obexelimab
B-lymphocyte antigen CD19 (CD19)
Monomethyl auristatin E
Obexelimab-6e linker
MDX-1342-6e [229]
MDX-1342
B-lymphocyte antigen CD19 (CD19)
Monomethyl auristatin E
MDX-1342-6e linker
MDX-1435-6e [229]
MDX-1435
B-lymphocyte antigen CD19 (CD19)
Monomethyl auristatin E
MDX-1435-6e linker
CHD37-6e [229]
cHD37
B-lymphocyte antigen CD19 (CD19)
Monomethyl auristatin E
cHD37-6e linker
AFM-11-6e [229]
AFM-11
B-lymphocyte antigen CD19 (CD19)
Monomethyl auristatin E
AFM-11-6e linker
AFM-12-6e [229]
AFM-12
B-lymphocyte antigen CD19 (CD19)
Monomethyl auristatin E
AFM-12-6e linker
GBR401-6e [229]
GBR401
B-lymphocyte antigen CD19 (CD19)
Monomethyl auristatin E
GBR401-6e linker
Denintuzumab-6e [229]
Denintuzumab
B-lymphocyte antigen CD19 (CD19)
Monomethyl auristatin E
Denintuzumab-6e linker
ADC14-0810 [230]
Cetuximab (LC) G7-CVIM
Epidermal growth factor receptor (EGFR)
Monomethyl auristatin F
ADC14-0810 linker
LCB14-0645 [230]
Cetuximab (LV) G7-CVIM
Epidermal growth factor receptor (EGFR)
Monomethyl auristatin F
LCB14-0645 linker
Cetuximab (LC)-2i [230]
Cetuximab (LC)
Epidermal growth factor receptor (EGFR)
Monomethyl auristatin F
Cetuximab(LC)-2i linker
Cetuximab (LC) G7-CVIM-3i [230]
Cetuximab (LC) G7-CVIM
Epidermal growth factor receptor (EGFR)
Monomethyl auristatin F
Cetuximab(LC) G7-CVIM-3i linker
Cetuximab (LV) G7-CVIM-3i [230]
Cetuximab (LV) G7-CVIM
Epidermal growth factor receptor (EGFR)
Monomethyl auristatin F
Cetuximab(LV) G7-CVIM-3i linker
Cetuximab (LC)-3i [230]
Cetuximab (LC)
Epidermal growth factor receptor (EGFR)
Monomethyl auristatin F
Cetuximab(LC)-3i linker
Cetuximab (LC) G7-CVIM-4i [230]
Cetuximab (LC) G7-CVIM
Epidermal growth factor receptor (EGFR)
Monomethyl auristatin F
Cetuximab(LC) G7-CVIM-4i linker
Cetuximab (LV) G7-CVIM-4i [230]
Cetuximab (LV) G7-CVIM
Epidermal growth factor receptor (EGFR)
Monomethyl auristatin F
Cetuximab(LV) G7-CVIM-4i linker
Cetuximab (LC)-4i [230]
Cetuximab (LC)
Epidermal growth factor receptor (EGFR)
Monomethyl auristatin F
Cetuximab(LC)-4i linker
Cetuximab (LC) G7-CVIM-6e [230]
Cetuximab (LC) G7-CVIM
Epidermal growth factor receptor (EGFR)
Monomethyl auristatin E
Cetuximab(LC) G7-CVIM-6e linker
Cetuximab (LV) G7-CVIM-6e [230]
Cetuximab (LV) G7-CVIM
Epidermal growth factor receptor (EGFR)
Monomethyl auristatin E
Cetuximab(LV) G7-CVIM-6e linker
Cetuximab (LC)-6e [230]
Cetuximab (LC)
Epidermal growth factor receptor (EGFR)
Monomethyl auristatin E
Cetuximab(LC)-6e linker
MYK-3 [231]
BA03
Epidermal growth factor receptor (EGFR)
Monomethyl auristatin E
Mc-Val-Cit-PABC
BA03-MC-MMAE [231]
BA03
Epidermal growth factor receptor (EGFR)
Monomethyl auristatin E
Mc-Val-Cit-PABC
BA03-MCC-MMAE [231]
BA03
Epidermal growth factor receptor (EGFR)
Monomethyl auristatin E
Mc-Val-Cit-PABC
TF-mAb-DM1 [232]
TF-mAb-SC1
Tissue factor (F3)
Mertansine DM1
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
TF-mAb-H29-DM1 [232]
TF-mAb-H29
Tissue factor (F3)
Mertansine DM1
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
TF-mAb-H30-DM1 [232]
TF-mAb-H30
Tissue factor (F3)
Mertansine DM1
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
TF-mAb-H31-DM1 [232]
TF-mAb-H31
Tissue factor (F3)
Mertansine DM1
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
TF-mAb-H32-DM1 [232]
TF-mAb-H32
Tissue factor (F3)
Mertansine DM1
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
TF-mAb-H33-DM1 [232]
TF-mAb-H33
Tissue factor (F3)
Mertansine DM1
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
TF-mAb-H34-DM1 [232]
TF-mAb-H34
Tissue factor (F3)
Mertansine DM1
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
TF-mAb-H35-DM1 [232]
TF-mAb-H35
Tissue factor (F3)
Mertansine DM1
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
TF-mAb-H36-DM1 [232]
TF-mAb-H36
Tissue factor (F3)
Mertansine DM1
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
TF-mAb-H37-DM1 [232]
TF-mAb-H37
Tissue factor (F3)
Mertansine DM1
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
TF-mAb-H38-DM1 [232]
TF-mAb-H38
Tissue factor (F3)
Mertansine DM1
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
TF-mAb-H39-DM1 [232]
TF-mAb-H39
Tissue factor (F3)
Mertansine DM1
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
TF-mAb-H40-DM1 [232]
TF-mAb-H40
Tissue factor (F3)
Mertansine DM1
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
TF-mAb-H41-DM1 [232]
TF-mAb-H41
Tissue factor (F3)
Mertansine DM1
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
TF-mAb-H42-DM1 [232]
TF-mAb-H42
Tissue factor (F3)
Mertansine DM1
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
TF-mAb-H43-DM1 [232]
TF-mAb-H43
Tissue factor (F3)
Mertansine DM1
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
TF-mAb-H44-DM1 [232]
TF-mAb-H44
Tissue factor (F3)
Mertansine DM1
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
TF-mAb-H45-DM1 [232]
TF-mAb-H45
Tissue factor (F3)
Mertansine DM1
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
TF-mAb-H46-DM1 [232]
TF-mAb-H46
Tissue factor (F3)
Mertansine DM1
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
TF-mAb-H47-DM1 [232]
TF-mAb-H47
Tissue factor (F3)
Mertansine DM1
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
TF-mAb-H48-DM1 [232]
TF-mAb-H48
Tissue factor (F3)
Mertansine DM1
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
TF-mAb-MMAE [232]
TF-mAb-SC1
Tissue factor (F3)
Monomethyl auristatin E
Mc-Val-Cit-PABC
TF-mAb-H29-MMAE [232]
TF-mAb-H29
Tissue factor (F3)
Monomethyl auristatin E
Mc-Val-Cit-PABC
TF-mAb-H30-MMAE [232]
TF-mAb-H30
Tissue factor (F3)
Monomethyl auristatin E
Mc-Val-Cit-PABC
TF-mAb-H31-MMAE [232]
TF-mAb-H31
Tissue factor (F3)
Monomethyl auristatin E
Mc-Val-Cit-PABC
TF-mAb-H32-MMAE [232]
TF-mAb-H32
Tissue factor (F3)
Monomethyl auristatin E
Mc-Val-Cit-PABC
TF-mAb-H33-MMAE [232]
TF-mAb-H33
Tissue factor (F3)
Monomethyl auristatin E
Mc-Val-Cit-PABC
TF-mAb-H34-MMAE [232]
TF-mAb-H34
Tissue factor (F3)
Monomethyl auristatin E
Mc-Val-Cit-PABC
TF-mAb-H35-MMAE [232]
TF-mAb-H35
Tissue factor (F3)
Monomethyl auristatin E
Mc-Val-Cit-PABC
TF-mAb-H36-MMAE [232]
TF-mAb-H36
Tissue factor (F3)
Monomethyl auristatin E
Mc-Val-Cit-PABC
TF-mAb-H37-MMAE [232]
TF-mAb-H37
Tissue factor (F3)
Monomethyl auristatin E
Mc-Val-Cit-PABC
TF-mAb-H38-MMAE [232]
TF-mAb-H38
Tissue factor (F3)
Monomethyl auristatin E
Mc-Val-Cit-PABC
TF-mAb-H39-MMAE [232]
TF-mAb-H39
Tissue factor (F3)
Monomethyl auristatin E
Mc-Val-Cit-PABC
TF-mAb-H40-MMAE [232]
TF-mAb-H40
Tissue factor (F3)
Monomethyl auristatin E
Mc-Val-Cit-PABC
TF-mAb-H41-MMAE [232]
TF-mAb-H41
Tissue factor (F3)
Monomethyl auristatin E
Mc-Val-Cit-PABC
TF-mAb-H42-MMAE [232]
TF-mAb-H42
Tissue factor (F3)
Monomethyl auristatin E
Mc-Val-Cit-PABC
TF-mAb-H43-MMAE [232]
TF-mAb-H43
Tissue factor (F3)
Monomethyl auristatin E
Mc-Val-Cit-PABC
TF-mAb-H44-MMAE [232]
TF-mAb-H44
Tissue factor (F3)
Monomethyl auristatin E
Mc-Val-Cit-PABC
TF-mAb-H45-MMAE [232]
TF-mAb-H45
Tissue factor (F3)
Monomethyl auristatin E
Mc-Val-Cit-PABC
TF-mAb-H46-MMAE [232]
TF-mAb-H46
Tissue factor (F3)
Monomethyl auristatin E
Mc-Val-Cit-PABC
TF-mAb-H47-MMAE [232]
TF-mAb-H47
Tissue factor (F3)
Monomethyl auristatin E
Mc-Val-Cit-PABC
TF-mAb-H48-MMAE [232]
TF-mAb-H48
Tissue factor (F3)
Monomethyl auristatin E
Mc-Val-Cit-PABC
RGCLN18.2-MC-Val-Cit-PAB-MMAE [233]
RGCLN18.2
Claudin-18.2 (CLDN18.2)
Monomethyl auristatin E
Mc-Val-Cit-PABC
RGCLN18.2-D07-Val-Cit-PAB-MMAE [233]
RGCLN18.2
Claudin-18.2 (CLDN18.2)
Monomethyl auristatin E
D07-Val-Cit-PABC
RGCLN18.2-PY-Val-Cit-PAB-MMAE [233]
RGCLN18.2
Claudin-18.2 (CLDN18.2)
Monomethyl auristatin E
PY-VC-PABC
IMAB362-MC-Val-Cit-PAB-MMAE [233]
IMAB362
Claudin-18.2 (CLDN18.2)
Monomethyl auristatin E
Mc-Val-Cit-PABC
WO2017089895A1 ADC1 [234]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
WO2017089895A1_ADC1 linker
WO2017089895A1 ADC2 [234]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin F
WO2017089895A1_ADC2 linker
WO2017089895A1 ADC3 [234]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
WO2017089895A1_ADC3 linker
WO2017089895A1 ADC4 [234]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin F
WO2017089895A1_ADC4 linker
WO2017089895A1 ADC5 [234]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
WO2017089895A1_ADC5 linker
WO2017089895A1 ADC6 [234]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin F
WO2017089895A1_ADC6 linker
WO2017089895A1 ADC7 [234]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
WO2017089895A1_ADC7 linker
WO2017089895A1 ADC8 [234]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin F
WO2017089895A1_ADC8 linker
WO2017089895A1 ADC9 [234]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
WO2017089895A1_ADC9 linker
WO2017089895A1 ADC10 [234]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
WO2017089895A1_ADC10 linker
WO2017089895A1 ADC11 [234]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
WO2017089895A1_ADC11 linker
WO2017089895A1 ADC12 [234]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
WO2017089895A1_ADC12 linker
WO2017089895A1 ADC13 [234]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
WO2017089895A1_ADC13 linker
WO2017089895A1 ADC14 [234]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin F
WO2017089895A1_ADC14 linker
WO2017089895A1 ADC15 [234]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
WO2017089895A1_ADC15 linker
WO2017089895A1 ADC16 [234]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin F
WO2017089895A1_ADC16 linker
WO2017089895A1 ADC17 [234]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
WO2017089895A1_ADC17 linker
WO2017089895A1 ADC18 [234]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin F
WO2017089895A1_ADC18 linker
WO2017089895A1 ADC19 [234]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
WO2017089895A1_ADC19 linker
WO2017089895A1 ADC20 [234]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin F
WO2017089895A1_ADC20 linker
WO2017089895A1 ADC86 [234]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin F
WO2017089895A1_ADC86 linker
WO2017089895A1 ADC87 [234]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
WO2017089895A1_ADC87 linker
WO2017089895A1 ADC23 [234]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin F
WO2017089895A1_ADC23 linker
WO2017089895A1 ADC24 [234]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
WO2017089895A1_ADC24 linker
WO2017089895A1 ADC25 [234]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
WO2017089895A1_ADC25 linker
WO2017089895A1 ADC26 [234]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
WO2017089895A1_ADC26 linker
WO2017089895A1 ADC27 [234]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
WO2017089895A1_ADC27 linker
WO2017089895A1 ADC28 [234]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
WO2017089895A1_ADC28 linker
WO2017089895A1 ADC29 [234]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
WO2017089895A1_ADC29 linker
WO2017089895A1 ADC30 [234]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
WO2017089895A1_ADC30 linker
WO2017089895A1 ADC31 [234]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
WO2017089895A1_ADC31 linker
WO2017089895A1 ADC32 [234]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
WO2017089895A1_ADC32 linker
WO2017089895A1 ADC33 [234]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
WO2017089895A1_ADC33 linker
WO2017089895A1 ADC34 [234]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin F
WO2017089895A1_ADC34 linker
WO2017089895A1 ADC35 [234]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
WO2017089895A1_ADC35 linker
WO2017089895A1 ADC36 [234]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
WO2017089895A1_ADC36 linker
WO2017089895A1 ADC37 [234]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
WO2017089895A1_ADC37 linker
WO2017089895A1 ADC38 [234]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin F
WO2017089895A1_ADC38 linker
WO2017089895A1 ADC39 [234]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
WO2017089895A1_ADC39 linker
WO2017089895A1 ADC40 [234]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin F
WO2017089895A1_ADC40 linker
WO2017089895A1 ADC41 [234]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
WO2017089895A1_ADC41 linker
WO2017089895A1 ADC42 [234]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin F
WO2017089895A1_ADC42 linker
WO2017089895A1 ADC43 [234]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
WO2017089895A1_ADC43 linker
WO2017089895A1 ADC44 [234]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin F
WO2017089895A1_ADC44 linker
WO2017089895A1 ADC45 [234]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
WO2017089895A1_ADC45 linker
WO2017089895A1 ADC46 [234]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin F
WO2017089895A1_ADC46 linker
WO2017089895A1 ADC47 [234]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
WO2017089895A1_ADC47 linker
WO2017089895A1 ADC48 [234]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin F
WO2017089895A1_ADC48 linker
WO2017089895A1 ADC49 [234]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
WO2017089895A1_ADC49 linker
WO2017089895A1 ADC50 [234]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin F
WO2017089895A1_ADC50 linker
WO2017089895A1 ADC51 [234]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
WO2017089895A1_ADC51 linker
WO2017089895A1 ADC52 [234]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
WO2017089895A1_ADC52 linker
WO2017089895A1 ADC53 [234]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin F
WO2017089895A1_ADC53 linker
WO2017089895A1 ADC54 [234]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin F
WO2017089895A1_ADC54 linker
WO2017089895A1 ADC55 [234]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin F
WO2017089895A1_ADC55 linker
WO2017089895A1 ADC76 [234]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin F
WO2017089895A1_ADC76 linker
WO2017089895A1 ADC88 [234]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin F
WO2017089895A1_ADC88 linker
WO2017089895A1 ADC89 [234]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin F
WO2017089895A1_ADC89 linker
WO2017089895A1 ADC90 [234]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin F
WO2017089895A1_ADC90 linker
WO2017089895A1 ADC91 [234]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
WO2017089895A1_ADC91 linker
WO2017089895A1 ADC60 [234]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin F
WO2017089895A1_ADC60 linker
WO2017089895A1 ADC61 [234]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
WO2017089895A1_ADC61 linker
WO2017089895A1 ADC62 [234]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin F
WO2017089895A1_ADC62 linker
WO2017089895A1 ADC63 [234]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
WO2017089895A1_ADC63 linker
WO2017089895A1 ADC77 [234]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin F
WO2017089895A1_ADC77 linker
WO2017089895A1 ADC64 [234]
Cetuximab
Epidermal growth factor receptor (EGFR)
Monomethyl auristatin F
WO2017089895A1_ADC64 linker
WO2017089895A1 ADC65 [234]
Cetuximab
Epidermal growth factor receptor (EGFR)
Monomethyl auristatin E
WO2017089895A1_ADC65 linker
WO2017089895A1 ADC66 [234]
Cetuximab
Epidermal growth factor receptor (EGFR)
Monomethyl auristatin F
WO2017089895A1_ADC66 linker
WO2017089895A1 ADC67 [234]
Anti-CD19 mAb DI-B4
B-lymphocyte antigen CD19 (CD19)
Monomethyl auristatin F
WO2017089895A1_ADC67 linker
WO2017089895A1 ADC68 [234]
Anti-CD19 mAb DI-B4
B-lymphocyte antigen CD19 (CD19)
Monomethyl auristatin E
WO2017089895A1_ADC68 linker
WO2017089895A1 ADC69 [234]
Anti-CD19 mAb DI-B4
B-lymphocyte antigen CD19 (CD19)
Monomethyl auristatin F
WO2017089895A1_ADC69 linker
WO2017089895A1 ADC70 [234]
Rituximab
B-lymphocyte antigen CD20 (MS4A1)
Monomethyl auristatin F
WO2017089895A1_ADC70 linker
WO2017089895A1 ADC71 [234]
Rituximab
B-lymphocyte antigen CD20 (MS4A1)
Monomethyl auristatin E
WO2017089895A1_ADC71 linker
WO2017089895A1 ADC72 [234]
Rituximab
B-lymphocyte antigen CD20 (MS4A1)
Monomethyl auristatin F
WO2017089895A1_ADC72 linker
WO2017089895A1 ADC73 [234]
Depatuxizumab
Epidermal growth factor receptor variant III (EGFRvIII)
Monomethyl auristatin F
WO2017089895A1_ADC73 linker
WO2017089895A1 ADC74 [234]
Depatuxizumab
Epidermal growth factor receptor variant III (EGFRvIII)
Monomethyl auristatin E
WO2017089895A1_ADC74 linker
WO2017089895A1 ADC75 [234]
Depatuxizumab
Epidermal growth factor receptor variant III (EGFRvIII)
Monomethyl auristatin F
WO2017089895A1_ADC75 linker
WO2021044208A1 ADC2 [235]
Anti-ROR1 mAb C2E3
Inactive tyrosine-protein kinase transmembrane receptor ROR1 (ROR1)
Monomethyl auristatin F
WO2021044208A1_ADC2 linker
WO2021044208A1 ADC3 [235]
Anti-ROR1 mAb C2E3
Inactive tyrosine-protein kinase transmembrane receptor ROR1 (ROR1)
Monomethyl auristatin E
WO2021044208A1_ADC3 linker
WO2021044208A1 ADC4 [235]
Anti-ROR1 mAb C2E3
Inactive tyrosine-protein kinase transmembrane receptor ROR1 (ROR1)
Monomethyl auristatin E
WO2021044208A1_ADC4 linker
WO2021044208A1 ADC5 [235]
Anti-ROR1 mAb C2E3
Inactive tyrosine-protein kinase transmembrane receptor ROR1 (ROR1)
Monomethyl auristatin E
WO2021044208A1_ADC5 linker
WO2021044208A1 ADC9 [235]
Anti-ROR1 mAb 2A2
Inactive tyrosine-protein kinase transmembrane receptor ROR1 (ROR1)
Monomethyl auristatin F
WO2021044208A1_ADC9 linker
WO2021044208A1 ADC10 [235]
Anti-ROR1 mAb 2A2
Inactive tyrosine-protein kinase transmembrane receptor ROR1 (ROR1)
Monomethyl auristatin E
WO2021044208A1_ADC10 linker
WO2021044208A1 ADC 2A2-4 [235]
Anti-ROR1 mAb 2A2
Inactive tyrosine-protein kinase transmembrane receptor ROR1 (ROR1)
Monomethyl auristatin E
WO2021044208A1_ADC 2A2-4 linker
WO2021044208A1 ADC 2A2-5 [235]
Anti-ROR1 mAb 2A2
Inactive tyrosine-protein kinase transmembrane receptor ROR1 (ROR1)
Monomethyl auristatin E
WO2021044208A1_ADC 2A2-5 linker
WO2021044208A1 ADC AB4-2 [235]
Anti-ROR1 mAb AB4
Inactive tyrosine-protein kinase transmembrane receptor ROR1 (ROR1)
Monomethyl auristatin F
WO2021044208A1_ADC AB4-2 linker
WO2021044208A1 ADC AB4-3 [235]
Anti-ROR1 mAb AB4
Inactive tyrosine-protein kinase transmembrane receptor ROR1 (ROR1)
Monomethyl auristatin E
WO2021044208A1_ADC AB4-3 linker
WO2021044208A1 ADC AB4-4 [235]
Anti-ROR1 mAb AB4
Inactive tyrosine-protein kinase transmembrane receptor ROR1 (ROR1)
Monomethyl auristatin E
WO2021044208A1_ADC AB4-4 linker
WO2021044208A1 ADC AB4-5 [235]
Anti-ROR1 mAb AB4
Inactive tyrosine-protein kinase transmembrane receptor ROR1 (ROR1)
Monomethyl auristatin E
WO2021044208A1_ADC AB4-5 linker
WO2021044208A1 ADC A2F2-2 [235]
Anti-ROR1 mAb A2F2
Inactive tyrosine-protein kinase transmembrane receptor ROR1 (ROR1)
Monomethyl auristatin F
WO2021044208A1_ADC A2F2-2 linker
WO2021044208A1 ADC A2F2-3 [235]
Anti-ROR1 mAb A2F2
Inactive tyrosine-protein kinase transmembrane receptor ROR1 (ROR1)
Monomethyl auristatin E
WO2021044208A1_ADC A2F2-3 linker
WO2021044208A1 ADC A2F2-4 [235]
Anti-ROR1 mAb A2F2
Inactive tyrosine-protein kinase transmembrane receptor ROR1 (ROR1)
Monomethyl auristatin E
WO2021044208A1_ADC A2F2-4 linker
WO2021044208A1 ADC A2F2-5 [235]
Anti-ROR1 mAb A2F2
Inactive tyrosine-protein kinase transmembrane receptor ROR1 (ROR1)
Monomethyl auristatin E
WO2021044208A1_ADC A2F2-5 linker
WO2021044208A1 ADC A2F3-2 [235]
Anti-ROR1 mAb A2F3
Inactive tyrosine-protein kinase transmembrane receptor ROR1 (ROR1)
Monomethyl auristatin F
WO2021044208A1_ADC A2F3-2 linker
WO2021044208A1 ADC A2F3-3 [235]
Anti-ROR1 mAb A2F3
Inactive tyrosine-protein kinase transmembrane receptor ROR1 (ROR1)
Monomethyl auristatin E
WO2021044208A1_ADC A2F3-3 linker
WO2021044208A1 ADC A2F3-4 [235]
Anti-ROR1 mAb A2F3
Inactive tyrosine-protein kinase transmembrane receptor ROR1 (ROR1)
Monomethyl auristatin E
WO2021044208A1_ADC A2F3-4 linker
WO2021044208A1 ADC A2F3-5 [235]
Anti-ROR1 mAb A2F3
Inactive tyrosine-protein kinase transmembrane receptor ROR1 (ROR1)
Monomethyl auristatin E
WO2021044208A1_ADC A2F3-5 linker
WO2021044208A1 ADC BA6-2 [235]
Anti-ROR1 mAb BA6
Inactive tyrosine-protein kinase transmembrane receptor ROR1 (ROR1)
Monomethyl auristatin F
WO2021044208A1_ADC BA6-2 linker
WO2021044208A1 ADC BA6-3 [235]
Anti-ROR1 mAb BA6
Inactive tyrosine-protein kinase transmembrane receptor ROR1 (ROR1)
Monomethyl auristatin E
WO2021044208A1_ADC BA6-3 linker
WO2021044208A1 ADC BA6-4 [235]
Anti-ROR1 mAb BA6
Inactive tyrosine-protein kinase transmembrane receptor ROR1 (ROR1)
Monomethyl auristatin E
WO2021044208A1_ADC BA6-4 linker
WO2021044208A1 ADC BA6-5 [235]
Anti-ROR1 mAb BA6
Inactive tyrosine-protein kinase transmembrane receptor ROR1 (ROR1)
Monomethyl auristatin E
WO2021044208A1_ADC BA6-5 linker
WO2021044208A1 ADC CC9-2 [235]
Anti-ROR1 mAb CC9
Inactive tyrosine-protein kinase transmembrane receptor ROR1 (ROR1)
Monomethyl auristatin F
WO2021044208A1_ADC CC9-2 linker
WO2021044208A1 ADC CC9-3 [235]
Anti-ROR1 mAb CC9
Inactive tyrosine-protein kinase transmembrane receptor ROR1 (ROR1)
Monomethyl auristatin E
WO2021044208A1_ADC CC9-3 linker
WO2021044208A1 ADC CC9-4 [235]
Anti-ROR1 mAb CC9
Inactive tyrosine-protein kinase transmembrane receptor ROR1 (ROR1)
Monomethyl auristatin E
WO2021044208A1_ADC CC9-4 linker
WO2021044208A1 ADC CC9-5 [235]
Anti-ROR1 mAb CC9
Inactive tyrosine-protein kinase transmembrane receptor ROR1 (ROR1)
Monomethyl auristatin E
WO2021044208A1_ADC CC9-5 linker
WO2021044208A1 ADC DG6-2 [235]
Anti-ROR1 mAb DG6
Inactive tyrosine-protein kinase transmembrane receptor ROR1 (ROR1)
Monomethyl auristatin F
WO2021044208A1_ADC DG6-2 linker
WO2021044208A1 ADC DG6-3 [235]
Anti-ROR1 mAb DG6
Inactive tyrosine-protein kinase transmembrane receptor ROR1 (ROR1)
Monomethyl auristatin E
WO2021044208A1_ADC DG6-3 linker
WO2021044208A1 ADC DG6-4 [235]
Anti-ROR1 mAb DG6
Inactive tyrosine-protein kinase transmembrane receptor ROR1 (ROR1)
Monomethyl auristatin E
WO2021044208A1_ADC DG6-4 linker
WO2021044208A1 ADC DG6-5 [235]
Anti-ROR1 mAb DG6
Inactive tyrosine-protein kinase transmembrane receptor ROR1 (ROR1)
Monomethyl auristatin E
WO2021044208A1_ADC DG6-5 linker
WO2021044208A1 ADC D2B12-2 [235]
Anti-ROR1 mAb D2B12
Inactive tyrosine-protein kinase transmembrane receptor ROR1 (ROR1)
Monomethyl auristatin F
WO2021044208A1_ADC D2B12-2 linker
WO2021044208A1 ADC D2B12-3 [235]
Anti-ROR1 mAb D2B12
Inactive tyrosine-protein kinase transmembrane receptor ROR1 (ROR1)
Monomethyl auristatin E
WO2021044208A1_ADC D2B12-3 linker
WO2021044208A1 ADC D2B12-4 [235]
Anti-ROR1 mAb D2B12
Inactive tyrosine-protein kinase transmembrane receptor ROR1 (ROR1)
Monomethyl auristatin E
WO2021044208A1_ADC D2B12-4 linker
WO2021044208A1 ADC D2B12-5 [235]
Anti-ROR1 mAb D2B12
Inactive tyrosine-protein kinase transmembrane receptor ROR1 (ROR1)
Monomethyl auristatin E
WO2021044208A1_ADC D2B12-5 linker
WO2021044208A1 ADC A2F2 M1-2 [235]
Anti-ROR1 mAb A2F2 M1
Inactive tyrosine-protein kinase transmembrane receptor ROR1 (ROR1)
Monomethyl auristatin F
WO2021044208A1_ADC A2F2 M1-2 linker
WO2021044208A1 ADC A2F2 M1-3 [235]
Anti-ROR1 mAb A2F2 M1
Inactive tyrosine-protein kinase transmembrane receptor ROR1 (ROR1)
Monomethyl auristatin E
WO2021044208A1_ADC A2F2 M1-3 linker
WO2021044208A1 ADC A2F2 M1-4 [235]
Anti-ROR1 mAb A2F2 M1
Inactive tyrosine-protein kinase transmembrane receptor ROR1 (ROR1)
Monomethyl auristatin E
WO2021044208A1_ADC A2F2 M1-4 linker
WO2021044208A1 ADC A2F2 M1-5 [235]
Anti-ROR1 mAb A2F2 M1
Inactive tyrosine-protein kinase transmembrane receptor ROR1 (ROR1)
Monomethyl auristatin E
WO2021044208A1_ADC A2F2 M1-5 linker
WO2007011968A2 cAC10-9a [236]
Brentuximab
Tumor necrosis factor receptor superfamily member 8 (TNFRSF8)
Monomethyl auristatin E
WO2007011968A2_cAC10-9a linker
WO2007011968A2 c1F6-9a [236]
Anti-CD70 mAb c1F6
CD70 antigen (CD70)
Monomethyl auristatin E
WO2007011968A2_c1F6-9a linker
WO2007011968A2 cAC10-9b [236]
Brentuximab
Tumor necrosis factor receptor superfamily member 8 (TNFRSF8)
Monomethyl auristatin F
WO2007011968A2_cAC10-9b linker
WO2007011968A2 c1F6-9b [236]
Anti-CD70 mAb c1F6
CD70 antigen (CD70)
Monomethyl auristatin F
WO2007011968A2_c1F6-9b linker
WO2015095755A1 h1F6-1.3 [237]
Anti-CD70 mAb h1F6
CD70 antigen (CD70)
Monomethyl auristatin E
WO2015095755A1_h1F6-1.3 linker
WO2015095755A1 cAC10-1.3 [237]
Brentuximab
Tumor necrosis factor receptor superfamily member 8 (TNFRSF8)
Monomethyl auristatin E
WO2015095755A1_cAC10-1.3 linker
WO2015095755A1 h1F6-2.0 [237]
Anti-CD70 mAb h1F6
CD70 antigen (CD70)
Monomethyl auristatin E
WO2015095755A1_h1F6-2.0 linker
WO2015095755A1 cAC10-2.0 [237]
Brentuximab
Tumor necrosis factor receptor superfamily member 8 (TNFRSF8)
Monomethyl auristatin E
WO2015095755A1_cAC10-2.0 linker
AAJ8D6-Mc-Val-Cit-MMAE [238]
AAJ8D6
Hepatocyte growth factor receptor (MET)
Monomethyl auristatin E
Mc-Val-Cit-PABC
AAJ8D6-D07-Val-Cit-PAB-MMAE [238]
AAJ8D6
Hepatocyte growth factor receptor (MET)
Monomethyl auristatin E
Mc-Val-Cit-PABC
AAJ8D6-PY-Val-Cit-MMAE [238]
AAJ8D6
Hepatocyte growth factor receptor (MET)
Monomethyl auristatin E
PY-VC-PABC
ABT-700-Mc-Val-Cit-MMAE [238]
Telisotuzumab
Hepatocyte growth factor receptor (MET)
Monomethyl auristatin E
Mc-Val-Cit-PABC
LgG1-Mc-Val-Cit-MMAE [238]
Anti-MET lgG1
Hepatocyte growth factor receptor (MET)
Monomethyl auristatin E
Mc-Val-Cit-PABC
RC88-PY-MAA-Val-Cit-PAB-MMAE [239]
Anti-MSLN mAb
Mesothelin (MSLN)
Monomethyl auristatin E
Mc-Val-Cit-PABC
RC88-PY-MAA-Val-Cit-PAB-MMAD [239]
Anti-MSLN mAb
Mesothelin (MSLN)
Monomethyl auristatin D
Mc-Val-Cit-PABC
RC88-Mc-Val-Cit-PAB-MMAE [239]
Anti-MSLN mAb
Mesothelin (MSLN)
Monomethyl auristatin E
Mc-Val-Cit-PABC
RC88-Mc-Val-Cit-PAB-MMAD [239]
Anti-MSLN mAb
Mesothelin (MSLN)
Monomethyl auristatin D
Mc-Val-Cit-PABC
hBU12-mcMMAF [240]
Denintuzumab
B-lymphocyte antigen CD19 (CD19)
Monomethyl auristatin F
Maleimido-caproyl
hBU12-MC-vc-PABC-MMAE [240]
Denintuzumab
B-lymphocyte antigen CD19 (CD19)
Monomethyl auristatin E
Mc-Val-Cit-PABC
hBU12-MC-vc-PABC-MMAF DAR4 [240]
Denintuzumab
B-lymphocyte antigen CD19 (CD19)
Monomethyl auristatin E
Mc-Val-Cit-PABC
hBU12-1 MMAE DAR4 [240]
Denintuzumab
B-lymphocyte antigen CD19 (CD19)
Monomethyl auristatin E
Phe-Dpr-MA
hBU12-1 MMAE DAR8 [240]
Denintuzumab
B-lymphocyte antigen CD19 (CD19)
Monomethyl auristatin E
Phe-Dpr-MA
hBU12-2 MMAE DAR4 [240]
Denintuzumab
B-lymphocyte antigen CD19 (CD19)
Monomethyl auristatin E
Phe-Glu-Dpr-MA
hBU12-2 MMAE DAR8 [240]
Denintuzumab
B-lymphocyte antigen CD19 (CD19)
Monomethyl auristatin E
Phe-Glu-Dpr-MA
hBU12-3 MMAE DAR4 [240]
Denintuzumab
B-lymphocyte antigen CD19 (CD19)
Monomethyl auristatin E
Thr-Dpr-MA
hBU12-3 MMAE DAR8 [240]
Denintuzumab
B-lymphocyte antigen CD19 (CD19)
Monomethyl auristatin E
Thr-Dpr-MA
hBU12-4 MMAE DAR4 [240]
Denintuzumab
B-lymphocyte antigen CD19 (CD19)
Monomethyl auristatin E
Thr-Glu-Dpr-MA
hBU12-4 MMAE DAR8 [240]
Denintuzumab
B-lymphocyte antigen CD19 (CD19)
Monomethyl auristatin E
Thr-Glu-Dpr-MA
hBU12-5 MMAE DAR4 [240]
Denintuzumab
B-lymphocyte antigen CD19 (CD19)
Monomethyl auristatin E
Phe-Glu-Dpr-MDpr
hBU12-5 MMAE DAR8 [240]
Denintuzumab
B-lymphocyte antigen CD19 (CD19)
Monomethyl auristatin E
Phe-Glu-Dpr-MDpr
hBU12-6 MMAE DAR4 [240]
Denintuzumab
B-lymphocyte antigen CD19 (CD19)
Monomethyl auristatin E
Thr-Glu-Dpr-MDpr
hBU12-6 MMAE DAR8 [240]
Denintuzumab
B-lymphocyte antigen CD19 (CD19)
Monomethyl auristatin E
Thr-Glu-Dpr-MDpr
hBU12-7 MMAE DAR4 [240]
Denintuzumab
B-lymphocyte antigen CD19 (CD19)
Monomethyl auristatin E
Thr-Glu-Lys-MDpr
hBU12-7 MMAE DAR8 [240]
Denintuzumab
B-lymphocyte antigen CD19 (CD19)
Monomethyl auristatin E
Thr-Glu-Lys-MDpr
hBU12-8 MMAE [240]
Denintuzumab
B-lymphocyte antigen CD19 (CD19)
Monomethyl auristatin E
Thiazole-Glu-Lys-MDpr
hBU12-9 MMAE [240]
Denintuzumab
B-lymphocyte antigen CD19 (CD19)
Monomethyl auristatin E
Phe-Glu-EDA-MDpr
hBU12-10 MMAE [240]
Denintuzumab
B-lymphocyte antigen CD19 (CD19)
Monomethyl auristatin E
Thr-Glu-EDA-MDpr
hBU12-11 MMAE [240]
Denintuzumab
B-lymphocyte antigen CD19 (CD19)
Monomethyl auristatin E
Phe-Ile-EDA-MDpr
hBU12-12 MMAE DAR4 [240]
Denintuzumab
B-lymphocyte antigen CD19 (CD19)
Monomethyl auristatin E
Thr-Ile-EDA-MDpr
hBU12-13 MMAE DAR4 [240]
Denintuzumab
B-lymphocyte antigen CD19 (CD19)
Monomethyl auristatin E
Thiazole-Glu-EDA-MDpr
hBU12-14 MMAE [240]
Denintuzumab
B-lymphocyte antigen CD19 (CD19)
Monomethyl auristatin E
Asp-Ala-Lys-MDpr
hBU12-15 MMAE [240]
Denintuzumab
B-lymphocyte antigen CD19 (CD19)
Monomethyl auristatin E
Glu-Ala-Lys-MDpr
hBU12-16 MMAE [240]
Denintuzumab
B-lymphocyte antigen CD19 (CD19)
Monomethyl auristatin E
PhosphoThr-Ala-Lys-MDpr
hBU12-17 MMAE [240]
Denintuzumab
B-lymphocyte antigen CD19 (CD19)
Monomethyl auristatin E
Asn-AlaGlu-Dpr-MDpr
hBU12-18 MMAE [240]
Denintuzumab
B-lymphocyte antigen CD19 (CD19)
Monomethyl auristatin E
Glu-Ala-Glu-Dpr-MDpr
hBU12-19 MMAE [240]
Denintuzumab
B-lymphocyte antigen CD19 (CD19)
Monomethyl auristatin E
Asp-AlaGlu-Dpr-MDpr
hBU12-20 MMAE [240]
Denintuzumab
B-lymphocyte antigen CD19 (CD19)
Monomethyl auristatin E
Glu-Ala-Glu-Dpr-MDpr
hBU12-21 MMAE [240]
Denintuzumab
B-lymphocyte antigen CD19 (CD19)
Monomethyl auristatin E
hSer-Ala-Glu-Dpr-MDpr
hBU12-22 MMAE [240]
Denintuzumab
B-lymphocyte antigen CD19 (CD19)
Monomethyl auristatin E
ValoH-AlaGlu-Dpr-MDpr
hBU12-23 MMAE [240]
Denintuzumab
B-lymphocyte antigen CD19 (CD19)
Monomethyl auristatin E
PhosphoThr-Ala-Glu-Dpr-MDpr
hBU12-24 MMAE [240]
Denintuzumab
B-lymphocyte antigen CD19 (CD19)
Monomethyl auristatin E
Pyrazole-Glu-Dpr-MDpr
hBU12-25 MMAE [240]
Denintuzumab
B-lymphocyte antigen CD19 (CD19)
Monomethyl auristatin E
Triazole-Glu-Dpr-MDpr
hBU12-26 MMAE [240]
Denintuzumab
B-lymphocyte antigen CD19 (CD19)
Monomethyl auristatin E
Asn-Glu-Dpr-MDpr
hBU12-27 MMAE [240]
Denintuzumab
B-lymphocyte antigen CD19 (CD19)
Monomethyl auristatin E
Asp-Glu-Dpr-MDpr
hBU12-28 MMAE [240]
Denintuzumab
B-lymphocyte antigen CD19 (CD19)
Monomethyl auristatin E
Fur-Glu-Dpr-MDpr
hBU12-29 MMAE [240]
Denintuzumab
B-lymphocyte antigen CD19 (CD19)
Monomethyl auristatin E
ValOH-Glu-Dpr-MDpr
hBU12-30 MMAE [240]
Denintuzumab
B-lymphocyte antigen CD19 (CD19)
Monomethyl auristatin E
Ser-Glu-Dpr-MDpr
hBU12-31 MMAE [240]
Denintuzumab
B-lymphocyte antigen CD19 (CD19)
Monomethyl auristatin E
hSer-Glu-Dpr-MDpr
hBU12-32 MMAE [240]
Denintuzumab
B-lymphocyte antigen CD19 (CD19)
Monomethyl auristatin E
Thr-IleLeu-Dpr-MDpr
hBU12-33 MMAE [240]
Denintuzumab
B-lymphocyte antigen CD19 (CD19)
Monomethyl auristatin E
Phe-Ile-Leu-Dpr-MDpr
hBU12-34 MMAE [240]
Denintuzumab
B-lymphocyte antigen CD19 (CD19)
Monomethyl auristatin E
Glu-Phe-Leu-Dpr-MDpr
hBU12-35 MMAE [240]
Denintuzumab
B-lymphocyte antigen CD19 (CD19)
Monomethyl auristatin E
Thr-LeuPhe-Dpr-MDpr
hBU12-36 MMAE [240]
Denintuzumab
B-lymphocyte antigen CD19 (CD19)
Monomethyl auristatin E
Phe-Leu-Phe-Dpr-MDpr
hBU12-37 MMAE [240]
Denintuzumab
B-lymphocyte antigen CD19 (CD19)
Monomethyl auristatin E
Glu-Phe-Phe-Dpr-MDpr
hBU12-38 MMAE [240]
Denintuzumab
B-lymphocyte antigen CD19 (CD19)
Monomethyl auristatin E
Thr-LysAla-Dpr-MDpr
hBU12-39 MMAE [240]
Denintuzumab
B-lymphocyte antigen CD19 (CD19)
Monomethyl auristatin E
Thr-Lys-Dpr-MDpr
hBU12-1 MMAF [240]
Denintuzumab
B-lymphocyte antigen CD19 (CD19)
Monomethyl auristatin F
Phe-Dpr-MA
hBU12-2 MMAF [240]
Denintuzumab
B-lymphocyte antigen CD19 (CD19)
Monomethyl auristatin F
Phe-Glu-Dpr-MA
hBU12-3 MMAF [240]
Denintuzumab
B-lymphocyte antigen CD19 (CD19)
Monomethyl auristatin F
Thr-Dpr-MA
hBU12-4 MMAF [240]
Denintuzumab
B-lymphocyte antigen CD19 (CD19)
Monomethyl auristatin F
Thr-Glu-Dpr-MA
hBU12-5 MMAF [240]
Denintuzumab
B-lymphocyte antigen CD19 (CD19)
Monomethyl auristatin F
Phe-Glu-Dpr-MDpr
hBU12-6 MMAF [240]
Denintuzumab
B-lymphocyte antigen CD19 (CD19)
Monomethyl auristatin F
Thr-Glu-Dpr-MDpr
hBU12-7 MMAF [240]
Denintuzumab
B-lymphocyte antigen CD19 (CD19)
Monomethyl auristatin F
Thr-Glu-Lys-MDpr
hBU12-8 MMAF [240]
Denintuzumab
B-lymphocyte antigen CD19 (CD19)
Monomethyl auristatin F
Thiazole-Glu-Lys-MDpr
hBU12-9 MMAF [240]
Denintuzumab
B-lymphocyte antigen CD19 (CD19)
Monomethyl auristatin F
Phe-Glu-EDA-MDpr
hBU12-10 MMAF [240]
Denintuzumab
B-lymphocyte antigen CD19 (CD19)
Monomethyl auristatin F
Thr-Glu-EDA-MDpr
hBU12-11 MMAF [240]
Denintuzumab
B-lymphocyte antigen CD19 (CD19)
Monomethyl auristatin F
Phe-Ile-EDA-MDpr
hBU12-12 MMAF [240]
Denintuzumab
B-lymphocyte antigen CD19 (CD19)
Monomethyl auristatin F
Thr-Ile-EDA-MDpr
hBU12-13 MMAF [240]
Denintuzumab
B-lymphocyte antigen CD19 (CD19)
Monomethyl auristatin F
Thiazole-Glu-EDA-MDpr
hBU12-14 MMAF [240]
Denintuzumab
B-lymphocyte antigen CD19 (CD19)
Monomethyl auristatin F
Asp-Ala-Lys-MDpr
hBU12-15 MMAF [240]
Denintuzumab
B-lymphocyte antigen CD19 (CD19)
Monomethyl auristatin F
Glu-Ala-Lys-MDpr
hBU12-16 MMAF [240]
Denintuzumab
B-lymphocyte antigen CD19 (CD19)
Monomethyl auristatin F
PhosphoThr-Ala-Lys-MDpr
hBU12-17 MMAF [240]
Denintuzumab
B-lymphocyte antigen CD19 (CD19)
Monomethyl auristatin F
Asn-AlaGlu-Dpr-MDpr
hBU12-18 MMAF [240]
Denintuzumab
B-lymphocyte antigen CD19 (CD19)
Monomethyl auristatin F
Glu-Ala-Glu-Dpr-MDpr
hBU12-19 MMAF [240]
Denintuzumab
B-lymphocyte antigen CD19 (CD19)
Monomethyl auristatin F
Asp-AlaGlu-Dpr-MDpr
hBU12-20 MMAF [240]
Denintuzumab
B-lymphocyte antigen CD19 (CD19)
Monomethyl auristatin F
Glu-Ala-Glu-Dpr-MDpr
hBU12-21 MMAF [240]
Denintuzumab
B-lymphocyte antigen CD19 (CD19)
Monomethyl auristatin F
hSer-Ala-Glu-Dpr-MDpr
hBU12-22 MMAF [240]
Denintuzumab
B-lymphocyte antigen CD19 (CD19)
Monomethyl auristatin F
ValoH-AlaGlu-Dpr-MDpr
hBU12-23 MMAF [240]
Denintuzumab
B-lymphocyte antigen CD19 (CD19)
Monomethyl auristatin F
PhosphoThr-Ala-Glu-Dpr-MDpr
hBU12-24 MMAF [240]
Denintuzumab
B-lymphocyte antigen CD19 (CD19)
Monomethyl auristatin F
Pyrazole-Glu-Dpr-MDpr
hBU12-25 MMAF [240]
Denintuzumab
B-lymphocyte antigen CD19 (CD19)
Monomethyl auristatin F
Triazole-Glu-Dpr-MDpr
hBU12-26 MMAF [240]
Denintuzumab
B-lymphocyte antigen CD19 (CD19)
Monomethyl auristatin F
Asn-Glu-Dpr-MDpr
hBU12-27 MMAF [240]
Denintuzumab
B-lymphocyte antigen CD19 (CD19)
Monomethyl auristatin F
Asp-Glu-Dpr-MDpr
hBU12-28 MMAF [240]
Denintuzumab
B-lymphocyte antigen CD19 (CD19)
Monomethyl auristatin F
Fur-Glu-Dpr-MDpr
hBU12-29 MMAF [240]
Denintuzumab
B-lymphocyte antigen CD19 (CD19)
Monomethyl auristatin F
ValOH-Glu-Dpr-MDpr
hBU12-30 MMAF [240]
Denintuzumab
B-lymphocyte antigen CD19 (CD19)
Monomethyl auristatin F
Ser-Glu-Dpr-MDpr
hBU12-31 MMAF [240]
Denintuzumab
B-lymphocyte antigen CD19 (CD19)
Monomethyl auristatin F
hSer-Glu-Dpr-MDpr
hBU12-32 MMAF [240]
Denintuzumab
B-lymphocyte antigen CD19 (CD19)
Monomethyl auristatin F
Thr-IleLeu-Dpr-MDpr
hBU12-33 MMAF [240]
Denintuzumab
B-lymphocyte antigen CD19 (CD19)
Monomethyl auristatin F
Phe-Ile-Leu-Dpr-MDpr
hBU12-34 MMAF [240]
Denintuzumab
B-lymphocyte antigen CD19 (CD19)
Monomethyl auristatin F
Glu-Phe-Leu-Dpr-MDpr
hBU12-35 MMAF [240]
Denintuzumab
B-lymphocyte antigen CD19 (CD19)
Monomethyl auristatin F
Thr-LeuPhe-Dpr-MDpr
hBU12-36 MMAF [240]
Denintuzumab
B-lymphocyte antigen CD19 (CD19)
Monomethyl auristatin F
Phe-Leu-Phe-Dpr-MDpr
hBU12-37 MMAF [240]
Denintuzumab
B-lymphocyte antigen CD19 (CD19)
Monomethyl auristatin F
Glu-Phe-Phe-Dpr-MDpr
hBU12-38 MMAF [240]
Denintuzumab
B-lymphocyte antigen CD19 (CD19)
Monomethyl auristatin F
Thr-LysAla-Dpr-MDpr
hBU12-39 MMAF [240]
Denintuzumab
B-lymphocyte antigen CD19 (CD19)
Monomethyl auristatin F
Thr-Lys-Dpr-MDpr
hBU12-MC-vc-PABC-MMAF DAR8 [240]
Denintuzumab
B-lymphocyte antigen CD19 (CD19)
Monomethyl auristatin E
Mc-Val-Cit-PABC
hBU12-13 MMAE DAR8 [240]
Denintuzumab
B-lymphocyte antigen CD19 (CD19)
Monomethyl auristatin E
Thiazole-Glu-EDA-MDpr
hBU12-12 MMAE DAR8 [240]
Denintuzumab
B-lymphocyte antigen CD19 (CD19)
Monomethyl auristatin E
Thr-Ile-EDA-MDpr
hBU12-11 MMAE DAR8 [240]
Denintuzumab
B-lymphocyte antigen CD19 (CD19)
Monomethyl auristatin E
Phe-Ile-EDA-MDpr
hBU12-17 MMAE DAR4 [240]
Denintuzumab
B-lymphocyte antigen CD19 (CD19)
Monomethyl auristatin E
Asn-AlaGlu-Dpr-MDpr
hBU12-20 MMAE DAR4 [240]
Denintuzumab
B-lymphocyte antigen CD19 (CD19)
Monomethyl auristatin E
Glu-Ala-Glu-Dpr-MDpr
hBU12-24 MMAE DAR4 [240]
Denintuzumab
B-lymphocyte antigen CD19 (CD19)
Monomethyl auristatin E
Pyrazole-Glu-Dpr-MDpr
hBU12-29 MMAE DAR4 [240]
Denintuzumab
B-lymphocyte antigen CD19 (CD19)
Monomethyl auristatin E
ValOH-Glu-Dpr-MDpr
hL49-ADC [241]
Humanized Anti-CD228 SGN-CD228A mAb
Melanotransferrin (MELTF)
Monomethyl auristatin E
mp-dLAE-PABC
hL49_27D_Ala-ADC [241]
hL49_27D_Ala
Melanotransferrin (MELTF)
Monomethyl auristatin E
mp-dLAE-PABC
hL49_27D_Gln-ADC [241]
hL49_27D_Gln
Melanotransferrin (MELTF)
Monomethyl auristatin E
mp-dLAE-PABC
hL49_27D_Tyr-ADC [241]
hL49_27D_Tyr
Melanotransferrin (MELTF)
Monomethyl auristatin E
mp-dLAE-PABC
hL49_34_Ala-ADC [241]
hL49_34_Ala
Melanotransferrin (MELTF)
Monomethyl auristatin E
mp-dLAE-PABC
hL49_34_Gln-ADC [241]
hL49_34_Gln
Melanotransferrin (MELTF)
Monomethyl auristatin E
mp-dLAE-PABC
hL49_34_Tyr-ADC [241]
hL49_34_Tyr
Melanotransferrin (MELTF)
Monomethyl auristatin E
mp-dLAE-PABC
hL49_3x_Ala-ADC [241]
hL49_3x_Ala
Melanotransferrin (MELTF)
Monomethyl auristatin E
mp-dLAE-PABC
hL49_3x_Gln-ADC [241]
hL49_3x_Gln
Melanotransferrin (MELTF)
Monomethyl auristatin E
mp-dLAE-PABC
hL49_3x_Tyr-ADC [241]
hL49_3x_Tyr
Melanotransferrin (MELTF)
Monomethyl auristatin E
mp-dLAE-PABC
M69-MMAE [242]
Anti-Matriptase mAb M69
Suppressor of tumorigenicity 14 protein (ST14)
Monomethyl auristatin E
Mc-Val-Cit-PABC
Zapadcine-1 [243]
Zaptuzumab
Tumor necrosis factor receptor superfamily member 10B (TNFRSF10B)
Monomethyl auristatin D
PY-VC-PABC
Wild type nBT062-DM4 [244]
Indatuximab
Syndecan-1 (SDC1)
Mertansine DM4
N-succinimidyl 4-(2-pyridyldithio) butanoate (SPDB)
Half nBT062-DM4 [244]
Indatuximab (C226S + C229S)
Syndecan-1 (SDC1)
Mertansine DM4
N-succinimidyl 4-(2-pyridyldithio) butanoate (SPDB)
Stable nBT062-DM4 [244]
Indatuximab (S228P + R409K)
Syndecan-1 (SDC1)
Mertansine DM4
N-succinimidyl 4-(2-pyridyldithio) butanoate (SPDB)
Bispecific nBT062-natalizumab-DM4 [244]
Bispecific nBT062-natalizumab
Syndecan-1 (SDC1); Integrin alpha-4 (ITGA4)
Mertansine DM4
N-succinimidyl 4-(2-pyridyldithio) butanoate (SPDB)
ScFvF7-Fc-vcMMAE [245]
Anti-FGFR2 scFv ECD_FGFR2
Fibroblast growth factor receptor 2 (FGFR2)
Monomethyl auristatin E
Mc-Val-Cit-PABC
Alpha-CD30-7 [246]
Anti-CD30 mAb
Tumor necrosis factor receptor superfamily member 8 (TNFRSF8)
Tubulysin 7
Glucuronide quaternary ammonium linker 7
Alpha-CD30-8 [246]
Anti-CD30 mAb
Tumor necrosis factor receptor superfamily member 8 (TNFRSF8)
Tubulysin 8
Glucuronide quaternary ammonium linker 8
Alpha-CD30-9 [246]
Anti-CD30 mAb
Tumor necrosis factor receptor superfamily member 8 (TNFRSF8)
Tubulysin 9
Glucuronide quaternary ammonium linker 9
VCit ADC 3a [247]
Anti-HER2 mAb glutamine 295 (Q295)
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin F
DBCO-PEG-VCit-PABC
EVCit ADC 3c [247]
Anti-HER2 mAb glutamine 295 (Q295)
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin F
DBCO-PEG-EVCit-PABC
EGFR-MMAU ADC [248]
Cetuximab
Epidermal growth factor receptor (EGFR)
Glucuronyl-monomethyl-auristatin E (MMAU)
Mc-Val-Cit-PABC
HER2-MMAU ADC [248]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Glucuronyl-monomethyl-auristatin E (MMAU)
Mc-Val-Cit-PABC
GABRP Ab-DM1 ADC [249]
GABRP-Ab
Gamma-aminobutyric acid receptor subunit pi (GABRP)
Mertansine DM1
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
Anti-alpha10-SAP [250]
Anti-integrin alpha10 mAb
Integrin alpha-10 (ITGA10)
Saporin
Undisclosed
ADC Mil40-6 [251]
Mil40
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
Silyl ether-based linker
Anti-CXCR4 ADC 513 [252]
Anti-CXCR4 mAb m17
C-X-C chemokine receptor type 4 (CXCR4)
Aur0131
AmPEG6C2
Anti-CXCR4 ADC 518 [252]
Anti-CXCR4 mAb m17
C-X-C chemokine receptor type 4 (CXCR4)
Auristatin 0101
AcLys-Val-Cit-PABC
Anti-CXCR4 ADC 510 [252]
Anti-CXCR4 mAb m17
C-X-C chemokine receptor type 4 (CXCR4)
Aur0131
AmPEG6C2
Anti-CXCR4 ADC 519 [252]
Anti-CXCR4 mAb m17
C-X-C chemokine receptor type 4 (CXCR4)
Auristatin 0101
AcLys-Val-Cit-PABC
Anti-CXCR4 ADC 381 [252]
Anti-CXCR4 mAb m17
C-X-C chemokine receptor type 4 (CXCR4)
Auristatin 0101
AcLys-Val-Cit-PABC
Anti-CXCR4 ADC 553 [252]
Anti-CXCR4 mAb h17-NA
C-X-C chemokine receptor type 4 (CXCR4)
Auristatin 0101
AcLys-Val-Cit-PABC
Anti-CXCR4 ADC 554 [252]
Anti-CXCR4 mAb h17-NS
C-X-C chemokine receptor type 4 (CXCR4)
Auristatin 0101
AcLys-Val-Cit-PABC
Anti-CXCR4 ADC 555 [252]
Anti-CXCR4 mAb h17-NQ
C-X-C chemokine receptor type 4 (CXCR4)
Auristatin 0101
AcLys-Val-Cit-PABC
Anti-CXCR4 ADC 556 [252]
Anti-CXCR4 mAb h17-NV.TS
C-X-C chemokine receptor type 4 (CXCR4)
Auristatin 0101
AcLys-Val-Cit-PABC
Anti-CXCR4 ADC 669 [252]
Anti-CXCR4 mAb h17-NQ
C-X-C chemokine receptor type 4 (CXCR4)
Aur0131
AmPEG6C2
Anti-CXCR4 ADC 670 [252]
Anti-CXCR4 mAb h17-NV.TS
C-X-C chemokine receptor type 4 (CXCR4)
Aur0131
AmPEG6C2
Anti-CXCR4 ADC 671 [252]
Anti-CXCR4 mAb h17-NA
C-X-C chemokine receptor type 4 (CXCR4)
Aur0131
AmPEG6C2
Anti-CXCR4 ADC 672 [252]
Anti-CXCR4 mAb h17-NS
C-X-C chemokine receptor type 4 (CXCR4)
Aur0131
AmPEG6C2
Anti-CXCR4 ADC 711 [252]
Anti-CXCR4 mAb h17-NA
C-X-C chemokine receptor type 4 (CXCR4)
Aur0131
AmPEG6C2
Anti-CXCR4 ADC 712 [252]
Anti-CXCR4 mAb h17-NA
C-X-C chemokine receptor type 4 (CXCR4)
Aur0131
AmPEG6C2
Anti-CXCR4 ADC 713 [252]
Anti-CXCR4 mAb h17-NV.TS
C-X-C chemokine receptor type 4 (CXCR4)
Aur0131
AmPEG6C2
Anti-CXCR4 ADC 714 [252]
Anti-CXCR4 mAb h17-NV.TS
C-X-C chemokine receptor type 4 (CXCR4)
Aur0131
AmPEG6C2
Cetux Cys-vc-MMAE [184]
Cetuximab
Epidermal growth factor receptor (EGFR)
Monomethyl auristatin E
Mc-Val-Cit-PABC
Cetux Fab-vc-MMAE [184]
Cetuximab Fab (conjugate to glycan residues)
Epidermal growth factor receptor (EGFR)
Monomethyl auristatin E
Mc-Val-Cit-PABC
Cetux Fc/Fab-vc-MMAE [184]
Cetuximab (Fc/Fab labeled with Neu5NAz)
Epidermal growth factor receptor (EGFR)
Monomethyl auristatin E
Mc-Val-Cit-PABC
ScFvGPIIb/IIIa-MMAE [253]
Anti-ITGA2B scFv
Integrin beta-3 (ITGB3)
Monomethyl auristatin E
Mc-Val-Cit-PABC
MMAE-9F7-F11 ADC [254]
Anti-HER3 mAb 9F7-F11
Receptor tyrosine-protein kinase erbB-3 (HER3)
Monomethyl auristatin E
Mc-Val-Cit-PABC
RBGO1-mcF [255]
Anti-RAGE mAb RBGO1
Advanced glycosylation end product-specific receptor (AGER)
Monomethyl auristatin F
Maleimido-caproyl
TTZ-1-MMAE [256]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
DSPh-Val-Ala-PABC
TTZ-2-MMAE [256]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
DSPh-Val-Cit-PABC
TTZ-3-MMAE [256]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
DSPh-PEG12-Val-Ala-PABC
TTZ-4-MMAE [256]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
DSPh-PEG12-Val-Cit-PABC
Trastuzumab-DVP-linker-MMAE 1 [257]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
DVP-based linker 1f
Trastuzumab-Val-Cit linker-MMAE 2 [257]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
Val-Cit linker 2e
Trastuzumab-DVP-linker-MMAE 3 [257]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
DVP-based linker 3
Trastuzumab-DVP-linker-MMAE 4 [257]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
DVP-based linker 4
B10v5 225-M-vc-MMAE [258]
B10v5 225-M
Epidermal growth factor receptor (EGFR); Hepatocyte growth factor receptor (MET)
Monomethyl auristatin E
Mc-Val-Cit-PABC
B10v5 225-H-vc-MMAE [258]
B10v5 225-H
Epidermal growth factor receptor (EGFR); Hepatocyte growth factor receptor (MET)
Monomethyl auristatin E
Mc-Val-Cit-PABC
B10 225-M-vc-MMAE [258]
B10 225-M
Epidermal growth factor receptor (EGFR); Hepatocyte growth factor receptor (MET)
Monomethyl auristatin E
Mc-Val-Cit-PABC
Cetuximab-vc-MMAE [258]
Cetuximab
Epidermal growth factor receptor (EGFR)
Monomethyl auristatin E
Mc-Val-Cit-PABC
Mil40-15 [202]
Mil40
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
Mc-PABC
M25ADCMMAF [259]
Anti-ALPPL2 mAb M25
Alkaline phosphatase, germ cell type (ALPG)
Monomethyl auristatin F
Mc-Val-Cit-PABC
M25ADCMMAE [259]
Anti-ALPPL2 mAb M25
Alkaline phosphatase, germ cell type (ALPG)
Monomethyl auristatin E
Mc-Val-Cit-PABC
FOLR1-Mal-PEG2-Val-Cit-PABC-Eribulin [260]
Farletuzumab
Folate receptor alpha (FOLR1)
Eribulin
Mal-PEG2-Val-Cit-PABC
FOLR1-Mal-PEG8-Val-Cit-PABC-Eribulin [260]
Farletuzumab
Folate receptor alpha (FOLR1)
Eribulin
Mal-PEG8-Val-Cit-PABC
FOLR1-Mal-Caproyl-Val-Cit-PABC-Eribulin [260]
Farletuzumab
Folate receptor alpha (FOLR1)
Eribulin
Maleimide-Caproyl-Val-Cit-PABC
FOLR1-Mal-PEG2-Ala-Ala-Asn-PABC-Eribulin [260]
Farletuzumab
Folate receptor alpha (FOLR1)
Eribulin
Mal-PEG2-Ala-Ala-Asn-PABC
FOLR1-Mal-PEG4-tria-PEG3-Dis-dim-PABC-Eribulin [260]
Farletuzumab
Folate receptor alpha (FOLR1)
Eribulin
Mal-PEG4-triazole-PEG3-Disulfidyl-dimethyl-PABC
FOLR1-Mal-PEG4-tria-PEG3-Sulfo-Eribulin [260]
Farletuzumab
Folate receptor alpha (FOLR1)
Eribulin
Mal-PEG4-triazole-PEG3-Sulfonamide
FOLR1-Mal-PEG2-Eribulin [260]
Farletuzumab
Folate receptor alpha (FOLR1)
Eribulin
Mal-PEG2
FOLR1-Mal-PEG4-Eribulin [260]
Farletuzumab
Folate receptor alpha (FOLR1)
Eribulin
Mal-PEG4
FOLR1-Suc/SPAAC-PEG4-Val-Cit-PABC-Eribulin [260]
Farletuzumab
Folate receptor alpha (FOLR1)
Eribulin
Succinamide-SPAAC-PEG4-Val-Cit-PABC
FOLR1-Suc/SPAAC-PEG3-Dis-dim-PABC-Eribulin [260]
Farletuzumab
Folate receptor alpha (FOLR1)
Eribulin
Succinamide-SPAAC-PEG3-Disylfidyl-dimethyl-PABC
FOLR1-Suc/SPAAC-PEG3-Sulfonamide-Eribulin [260]
Farletuzumab
Folate receptor alpha (FOLR1)
Eribulin
Succinamide-SPAAC-PEG3-Sulfonamide
FOLR1-Suc/SPAAC-PEG2-Eribulin [260]
Farletuzumab
Folate receptor alpha (FOLR1)
Eribulin
Succinamide-SPAAC-PEG2
FOLR1-Suc/SPAAC-PEG4-Eribulin [260]
Farletuzumab
Folate receptor alpha (FOLR1)
Eribulin
Succinamide-SPAAC-PEG4
FOLR1-Mal-PEG-Val-Cit-PABC-Cryptophycin [260]
Farletuzumab
Folate receptor alpha (FOLR1)
Cryptophycin
Mal-PEG-Val-Cit-PABC
FOLR1-Mal-Caproyl-Val-Cit-PABC-MMAE [260]
Farletuzumab
Folate receptor alpha (FOLR1)
Monomethyl auristatin E
Maleimide-Caproyl-Val-Cit-PABC
FOLR1-Mal-Caproyl-Val-Cit-PABC-MMAF [260]
Farletuzumab
Folate receptor alpha (FOLR1)
Monomethyl auristatin F
Maleimide-Caproyl-Val-Cit-PABC
MSLN-Mal-PEG2-Val-Cit-PABC-Eribulin [260]
Amatuximab
Mesothelin (MSLN)
Eribulin
Mal-PEG2-Val-Cit-PABC
MSLN-Mal-PEG8-Val-Cit-PABC-Eribulin [260]
Amatuximab
Mesothelin (MSLN)
Eribulin
Mal-PEG8-Val-Cit-PABC
MSLN-Mal-Caproyl-Val-Cit-PABC-Eribulin [260]
Amatuximab
Mesothelin (MSLN)
Eribulin
Maleimide-Caproyl-Val-Cit-PABC
MSLN-Mal-PEG2-Ala-Ala-Asn-PABC-Eribulin [260]
Amatuximab
Mesothelin (MSLN)
Eribulin
Mal-PEG2-Ala-Ala-Asn-PABC
MSLN-Mal-PEG4-tria-PEG3-Dis-dim-PABC-Eribulin [260]
Amatuximab
Mesothelin (MSLN)
Eribulin
Mal-PEG4-triazole-PEG3-Disulfidyl-dimethyl-PABC
MSLN-Mal-PEG4-tria-PEG3-Sulfo-Eribulin [260]
Amatuximab
Mesothelin (MSLN)
Eribulin
Mal-PEG4-triazole-PEG3-Sulfonamide
MSLN-Mal-PEG2-Eribulin [260]
Amatuximab
Mesothelin (MSLN)
Eribulin
Mal-PEG2
MSLN-Mal-PEG4-Eribulin [260]
Amatuximab
Mesothelin (MSLN)
Eribulin
Mal-PEG4
MSLN-Suc/SPAAC-PEG4-Val-Cit-PABC-Eribulin [260]
Amatuximab
Mesothelin (MSLN)
Eribulin
Succinamide-SPAAC-PEG4-Val-Cit-PABC
MSLN-Suc/SPAAC-PEG3-Dis-dim-PABC-Eribulin [260]
Amatuximab
Mesothelin (MSLN)
Eribulin
Succinamide-SPAAC-PEG3-Disylfidyl-dimethyl-PABC
MSLN-Suc/SPAAC-PEG3-Sulfonamide-Eribulin [260]
Amatuximab
Mesothelin (MSLN)
Eribulin
Succinamide-SPAAC-PEG3-Sulfonamide
MSLN-Suc/SPAAC-PEG2-Eribulin [260]
Amatuximab
Mesothelin (MSLN)
Eribulin
Succinamide-SPAAC-PEG2
MSLN-Suc/SPAAC-PEG4-Eribulin [260]
Amatuximab
Mesothelin (MSLN)
Eribulin
Succinamide-SPAAC-PEG4
MSLN-Mal-PEG-Val-Cit-PABC-Cryptophycin [260]
Amatuximab
Mesothelin (MSLN)
Cryptophycin
Mal-PEG-Val-Cit-PABC
MSLN-Mal-Caproyl-Val-Cit-PABC-MMAE [260]
Amatuximab
Mesothelin (MSLN)
Monomethyl auristatin E
Maleimide-Caproyl-Val-Cit-PABC
MSLN-Mal-Caproyl-Val-Cit-PABC-MMAF [260]
Amatuximab
Mesothelin (MSLN)
Monomethyl auristatin F
Maleimide-Caproyl-Val-Cit-PABC
Farletuzumab-sulfo SPDB-DM4 [260]
Farletuzumab
Folate receptor alpha (FOLR1)
Mertansine DM4
Sulfo-SPDB
Crown Ether ADC 4a [261]
Brentuximab
Tumor necrosis factor receptor superfamily member 8 (TNFRSF8)
Monomethyl auristatin E
6-Amino-alpha-cyclodextrin-Val-Cit-PABC
Crown Ether ADC 4b [261]
Brentuximab
Tumor necrosis factor receptor superfamily member 8 (TNFRSF8)
Monomethyl auristatin E
6-Amino-beta-cyclodextrin-Val-Cit-PABC
Crown Ether ADC 4c [261]
Brentuximab
Tumor necrosis factor receptor superfamily member 8 (TNFRSF8)
Monomethyl auristatin E
6-Amino-gama-cyclodextrin-Val-Cit-PABC
Crown Ether ADC 4d [261]
Brentuximab
Tumor necrosis factor receptor superfamily member 8 (TNFRSF8)
Monomethyl auristatin E
3-Amino-alpha-cyclodextrin-Val-Cit-PABC
Crown Ether ADC 4e [261]
Brentuximab
Tumor necrosis factor receptor superfamily member 8 (TNFRSF8)
Monomethyl auristatin E
3-Amino-beta-cyclodextrin-Val-Cit-PABC
Crown Ether ADC 4f [261]
Brentuximab
Tumor necrosis factor receptor superfamily member 8 (TNFRSF8)
Monomethyl auristatin E
3-Amino-gama-cyclodextrin-Val-Cit-PABC
Crown Ether ADC 5a [261]
Brentuximab
Tumor necrosis factor receptor superfamily member 8 (TNFRSF8)
Monomethyl auristatin E
1-Aza-24-crown-8-Val-Cit-PABC
Crown Ether ADC 5b [261]
Brentuximab
Tumor necrosis factor receptor superfamily member 8 (TNFRSF8)
Monomethyl auristatin E
1-Aza-42-crown-14-Val-Cit-PABC
Crown Ether ADC 6a [261]
Brentuximab
Tumor necrosis factor receptor superfamily member 8 (TNFRSF8)
Monomethyl auristatin E
PEG(8u)-Val-Cit-PABC
Crown Ether ADC 6b [261]
Brentuximab
Tumor necrosis factor receptor superfamily member 8 (TNFRSF8)
Monomethyl auristatin E
PEG(24u)-Val-Cit-PABC
Ch14.18-MMAE [262]
Anti-GD2 mAb ch14.18
Ganglioside GD2 (GD2)
Monomethyl auristatin E
Mc-Val-Cit-PABC
Ch14.18-MMAF [262]
Anti-GD2 mAb ch14.18
Ganglioside GD2 (GD2)
Monomethyl auristatin F
Mc-Val-Cit-PABC
HER2-acetal-ADC 11 [263]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin F
Clravable-acetal based linker 11
HER2-acetal-ADC 12 [263]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin F
Clravable-TAMRA-acetal based linker 12
HER2-azide-alkyne MMAE conjugate [264]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
Azide-alkyne based linker 10a
HER2-cyclopropene-tetrazine MMAE conjugate [264]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
Cyclopropene-tetrazine based linker 10b
HER2-norbornene-tetrazine MMAE conjugate [264]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
Norbornene-tetrazine based linker 10c
5E3-Saporin ADC [265]
Anti-SEMA4A mAb 5E3
Semaphorin-4A (SEMA4A)
Saporin
Undisclosed
5E3-vedotin [265]
Anti-SEMA4A mAb 5E3
Semaphorin-4A (SEMA4A)
Monomethyl auristatin E
Mc-Val-Cit-PABC
5E3-emtansine [265]
Anti-SEMA4A mAb 5E3
Semaphorin-4A (SEMA4A)
Mertansine DM1
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
Trastuzumab biosimilar mil40 12a [266]
Mil40
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
Maleamic methyl ester-based Val-Ala-PABC linker 12a
Trastuzumab biosimilar mil40 12b [266]
Mil40
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
Maleamic methyl ester-based Val-Ala-PABC linker 12b
Trastuzumab biosimilar mil40 12c [266]
Mil40
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
Maleamic methyl ester-based Val-Cit-PABC linker 12c
T-FcBP-DM1 [267]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Mertansine DM1
N-terminal norbornene group pFcBP linker
T-D8-1508 [268]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
AZ-1508
Cysteine D8
T-D6-1508 [268]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
AZ-1508
Cysteine D6
T-D4-1508 [268]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
AZ-1508
Cysteine D4
T-D2-1508 [268]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
AZ-1508
Cysteine D2
N-D8-1508 [268]
NIP228
Epidermal growth factor receptor (EGFR); Receptor tyrosine-protein kinase erbB-3 (HER3)
AZ-1508
Cysteine D8
N-D6-1508 [268]
NIP228
Epidermal growth factor receptor (EGFR); Receptor tyrosine-protein kinase erbB-3 (HER3)
AZ-1508
Cysteine D6
N-D4-1508 [268]
NIP228
Epidermal growth factor receptor (EGFR); Receptor tyrosine-protein kinase erbB-3 (HER3)
AZ-1508
Cysteine D4
N-D2-1508 [268]
NIP228
Epidermal growth factor receptor (EGFR); Receptor tyrosine-protein kinase erbB-3 (HER3)
AZ-1508
Cysteine D2
THL4-mpeoDM1 [269]
Anti-DLL4 mAb THL4 (V207C, A121C)
Delta-like protein 4 (DLL4)
Mertansine DM1
BIMPRO
TH2-mpeoDM1 [269]
Anti-DLL4 mAb TH2 (A121C)
Delta-like protein 4 (DLL4)
Mertansine DM1
BIMPRO
TL2-mpeoDM1 [269]
Anti-DLL4 mAb TL2 (V207C)
Delta-like protein 4 (DLL4)
Mertansine DM1
BIMPRO
THL4-vcMMAE [269]
Anti-DLL4 mAb THL4 (V207C, A121C)
Delta-like protein 4 (DLL4)
Monomethyl auristatin E
Mc-Val-Cit-PABC
H3L2-mpeoDM1 [269]
Anti-DLL4 mAb H3L2
Delta-like protein 4 (DLL4)
Mertansine DM1
BIMPRO
CTX-MMAE [270]
Cetuximab
Epidermal growth factor receptor (EGFR)
Monomethyl auristatin E
PD-Val-Cit-PABC
H32-DM1_3.0 [271]
Anti-HER2 mAb H32
Receptor tyrosine-protein kinase erbB-2 (HER2)
Mertansine DM1
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
H32-DM1_3.3 [271]
Anti-HER2 mAb H32
Receptor tyrosine-protein kinase erbB-2 (HER2)
Mertansine DM1
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
H32-DM1_3.7 [271]
Anti-HER2 mAb H32
Receptor tyrosine-protein kinase erbB-2 (HER2)
Mertansine DM1
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
H32-DM1_3.8 [271]
Anti-HER2 mAb H32
Receptor tyrosine-protein kinase erbB-2 (HER2)
Mertansine DM1
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
H32-VCMMAE_2.1 [271]
Anti-HER2 mAb H32
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
Mc-Val-Cit-PABC
H32-VCMMAE_3.2 [271]
Anti-HER2 mAb H32
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
Mc-Val-Cit-PABC
H32-VCMMAE_3.8 [271]
Anti-HER2 mAb H32
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
Mc-Val-Cit-PABC
H32-VCMMAE_6.6 [271]
Anti-HER2 mAb H32
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
Mc-Val-Cit-PABC
HER2 ADC-18 [272]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
Vinylsulfonamide based linker 15
HER2 ADC-19 [272]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
Vinylsulfonamide based linker 16
HER2 ADC-20 [272]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
Vinylsulfonamide based linker 17
EGFR ADC-21 [272]
Cetuximab
Epidermal growth factor receptor (EGFR)
Monomethyl auristatin E
Vinylsulfonamide based linker 15
EGFR ADC-22 [272]
Cetuximab
Epidermal growth factor receptor (EGFR)
Monomethyl auristatin E
Vinylsulfonamide based linker 16
EGFR ADC-23 [272]
Cetuximab
Epidermal growth factor receptor (EGFR)
Monomethyl auristatin E
Vinylsulfonamide based linker 17
T-DM1-IR700 [273]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Mertansine DM1 plus IRDye700DX
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
Trastuzumab I253Q-MMAE [274]
Trastuzumab I253Q
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
Dansylcadaverine-BCN based linker
Trastuzumab deglycosylated WT-MMAE [274]
Trastuzumab I253Q
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
Dansylcadaverine deglycosylated-BCN based linker
HER2-gsADC-1 [275]
CHO-S2G2F-Tras (Ab1)
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
ThioPz linker 6a
HER2-gsADC-2 [275]
CHO-S2G2F-Tras (Ab1)
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
2-Aminobenzamide oxime
HER2-gsADC-3 [275]
CHO-S2G2F-Tras (Ab1)
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
Hydroxylamine derivative 6c
HER2-gsADC-4 [275]
CHO-S2G2F-Tras (Ab1)
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
PEGylation linker 6n
HER2-gsADC-5 [275]
Azido-tagged trastuzumab (Ab2)
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
Azadibenzocylooctyne-amine derivative 6d
HER2-gsADC-6 [275]
Azido-tagged trastuzumab (Ab2)
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
Bicyclononyne derivative 6e
HER2-gsADC-7 [275]
Azido-tagged trastuzumab (Ab2)
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
PEGylation linker 6m
HER2-gsADC-8 [275]
Azido-tagged trastuzumab (Ab2)
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
Glycosyl PEGylation linker 6r
HER2-gsADC-9 [275]
Azido-tagged trastuzumab (Ab3)
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
Linear alkyne 6f
HER2-gsADC-10 [275]
Azido-tagged trastuzumab (Ab3)
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
PEGylation linker 6g
HER2-gsADC-11 [275]
Azido-tagged trastuzumab (Ab3)
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
PEGylation linker 6h
HER2-gsADC-12 [275]
Azido-tagged trastuzumab (Ab3)
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
PEGylation linker 6i
HER2-gsADC-13 [275]
Azido-tagged trastuzumab (Ab3)
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
PEGylation linker 6j
HER2-gsADC-14 [275]
Azido-tagged trastuzumab (Ab3)
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
PEGylation linker 6k
HER2-gsADC-15 [275]
Azido-tagged trastuzumab (Ab3)
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
PEGylation linker 6l
HER2-gsADC-16 [275]
Azido-tagged trastuzumab (Ab3)
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
PEGylation linker 6m
HER2-gsADC-17 [275]
Azido-tagged trastuzumab (Ab3)
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
Noncleavable linker 6t
HER2-gsADC-18 [275]
CHO-G2F-Tras (Ab4)
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
ThioPz linker 6a
HER2-gsADC-19 [275]
CHO-G2F-Tras (Ab4)
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
2-Aminobenzamide oxime
HER2-gsADC-20 [275]
CHO-G2F-Tras (Ab4)
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
Hydroxylamine derivative 6c
HER2-gsADC-21 [275]
CHO-G2F-Tras (Ab4)
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
PEGylation linker 6n
HER2-gsADC-22 [275]
Azido-tagged trastuzumab (Ab5)
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
Linear alkyne 6f
HER2-gsADC-23 [275]
Azido-tagged trastuzumab (Ab5)
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
PEGylation linker 6g
HER2-gsADC-24 [275]
Azido-tagged trastuzumab (Ab5)
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
PEGylation linker 6h
HER2-gsADC-25 [275]
Azido-tagged trastuzumab (Ab5)
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
PEGylation linker 6i
HER2-gsADC-26 [275]
Azido-tagged trastuzumab (Ab5)
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
PEGylation linker 6j
HER2-gsADC-27 [275]
Azido-tagged trastuzumab (Ab5)
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
PEGylation linker 6k
HER2-gsADC-28 [275]
Azido-tagged trastuzumab (Ab5)
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
PEGylation linker 6l
HER2-gsADC-29 [275]
Azido-tagged trastuzumab (Ab5)
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
PEGylation linker 6m
HER2-gsADC-30 [275]
Azido-tagged trastuzumab (Ab5)
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
Glycosyl PEGylation linker 6o
HER2-gsADC-31 [275]
Azido-tagged trastuzumab (Ab5)
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
Glycosyl PEGylation linker 6p
HER2-gsADC-32 [275]
Azido-tagged trastuzumab (Ab5)
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
Glycosyl PEGylation linker 6q
HER2-gsADC-33 [275]
Azido-tagged trastuzumab (Ab5)
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
Glycosyl PEGylation linker 6r
HER2-gsADC-34 [275]
Azido-tagged trastuzumab (Ab6)
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
Linear alkyne 6f
HER2-gsADC-35 [275]
Azido-tagged trastuzumab (Ab6)
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
PEGylation linker 6g
HER2-gsADC-36 [275]
Azido-tagged trastuzumab (Ab6)
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
PEGylation linker 6h
HER2-gsADC-37 [275]
Azido-tagged trastuzumab (Ab6)
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
PEGylation linker 6i
HER2-gsADC-38 [275]
Azido-tagged trastuzumab (Ab6)
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
PEGylation linker 6j
HER2-gsADC-39 [275]
Azido-tagged trastuzumab (Ab6)
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
PEGylation linker 6k
HER2-gsADC-40 [275]
Azido-tagged trastuzumab (Ab6)
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
PEGylation linker 6l
HER2-gsADC-41 [275]
Az-LacNAc-Tras Ab7
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
Bicyclononyne derivative 6e
HER2-gsADC-42 [275]
Az-LacNAc-Tras Ab7
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
PEGylation linker 6l
HER2-gsADC-43 [275]
Az-LacNAc-Tras Ab7
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
PEGylation linker 6m
HER2-gsADC-44 [275]
Az-LacNAc-Tras Ab7
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
Noncleavable linker 6s
HER2-gsADC-45 [275]
Az-LacNAc-Tras Ab7
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
Noncleavable linker 6t
HER2-gsADC-46 [275]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
ThioPz linker 6a
HER2-gsADC-47 [275]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
Hydroxylamine derivative 6c
HER2-gsADC-48 [275]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
2-Aminobenzamide oxime
HER2-gsADC-49 [275]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
Azadibenzocylooctyne-amine derivative 6d
HER2-gsADC-50 [275]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
2-Aminobenzamidoxime without core-fucosylation
T-DM1-2.6 [275]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Mertansine DM1
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
AXL02-MMAE [276]
Anti-AXL mAb AXL02
Tyrosine-protein kinase receptor UFO (AXL)
Monomethyl auristatin E
Mc-Val-Cit-PABC
NOV0712-DM4 [277]
Anti-CDH6 mAb NOV0712
Cadherin-6 (CDH6)
Mertansine DM4
Sulfo-SPDB
H01L02-DM4 [277]
Anti-CDH6 mAb H01L02
Cadherin-6 (CDH6)
Mertansine DM4
Sulfo-SPDB
hu4DFabv7-BMPEO-DM1 [278]
hu4DFabv7
Receptor tyrosine-protein kinase erbB-2 (HER2)
Maytansinoid DM1
hu4DFabv7-BMPEO-DM1 linker
hu4DFabv8 (A121C)-BMPEO-DM1 [278]
hu4DFabv8 (A121C)
Receptor tyrosine-protein kinase erbB-2 (HER2)
Maytansinoid DM1
hu4DFabv8 (A121C)-BMPEO-DM1 linker
hu4DFabv8 (V110C)-BMPEO-DM1 [278]
hu4DFabv8 (V110C)
Receptor tyrosine-protein kinase erbB-2 (HER2)
Maytansinoid DM1
hu4DFabv8 (V110C)-BMPEO-DM1 linker
Thio-Tr (A121C)-BMPEO-DM1 [278]
Thio-Tr (A121C)
Receptor tyrosine-protein kinase erbB-2 (HER2)
Maytansinoid DM1
Thio-Tr (A121C)-BMPEO-DM1 linker
2H9-A121C-BMPEO-DM1 [278]
Anti-HER2 antibody 2H9-A121C
Receptor tyrosine-protein kinase erbB-2 (HER2)
Maytansinoid DM1
2H9-A121C-BMPEO-DM1 linker
Thio-3A5 (A121C)-BMPEO-DM1 [278]
Thio-3A5 (A121C)
Mucin-16 (MUC16)
Maytansinoid DM1
Thio-3A5 (A121C)-BMPEO-DM1 linker
Anti-MUC16 antibody 3A5-BMPEO-DM1 [278]
Anti-MUC16 antibody 3A5
Mucin-16 (MUC16)
Maytansinoid DM1
Anti-MUC16 antibody 3A5-BMPEO-DM1 linker
Thio-Tmab-BMPEO-DM1 [278]
Thio-Tmab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Maytansinoid DM1
Thio-Tmab-BMPEO-DM1 linker
hu4DFabv8 (V110C)-MC-MMAF [278]
hu4DFabv8 (V110C)
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin F
Maleimido-caproyl
hu4DFabv8 (V110C)-MC-MMAE [278]
hu4DFabv8 (V110C)
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
Maleimido-caproyl
hu4DFabv8 (V110C)-MC-Val-Cit-PAB-MMAF [278]
hu4DFabv8 (V110C)
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin F
Mc-Val-Cit-PABC
hu4DFabv8 (V110C)-MC-Val-Cit-PAB-MMAE [278]
hu4DFabv8 (V110C)
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
Mc-Val-Cit-PABC
hu4DFabv8 (L-V15C)-BMPEO-DM1 [278]
hu4DFabv8 (L-V15C)
Receptor tyrosine-protein kinase erbB-2 (HER2)
Maytansinoid DM1
hu4DFabv8 (L-V15C)-BMPEO-DM1 linker
hu4DFabv8 (L-A43C)-BMPEO-DM1 [278]
hu4DFabv8 (L-A43C)
Receptor tyrosine-protein kinase erbB-2 (HER2)
Maytansinoid DM1
hu4DFabv8 (L-A43C)-BMPEO-DM1 linker
hu4DFabv8 (L-A144C)-BMPEO-DM1 [278]
hu4DFabv8 (L-A144C)
Receptor tyrosine-protein kinase erbB-2 (HER2)
Maytansinoid DM1
hu4DFabv8 (L-A144C)-BMPEO-DM1 linker
hu4DFabv8 (L-S168C)-BMPEO-DM1 [278]
hu4DFabv8 (L-S168C)
Receptor tyrosine-protein kinase erbB-2 (HER2)
Maytansinoid DM1
hu4DFabv8 (L-S168C)-BMPEO-DM1 linker
hu4DFabv8 (H-A40C)-BMPEO-DM1 [278]
hu4DFabv8 (H-A40C)
Receptor tyrosine-protein kinase erbB-2 (HER2)
Maytansinoid DM1
hu4DFabv8 (H-A40C)-BMPEO-DM1 linker
hu4DFabv8 (H-A88C)-BMPEO-DM1 [278]
hu4DFabv8 (H-A88C)
Receptor tyrosine-protein kinase erbB-2 (HER2)
Maytansinoid DM1
hu4DFabv8 (H-A88C)-BMPEO-DM1 linker
hu4DFabv8 (H-S119C)-BMPEO-DM1 [278]
hu4DFabv8 (H-S119C)
Receptor tyrosine-protein kinase erbB-2 (HER2)
Maytansinoid DM1
hu4DFabv8 (H-S119C)-BMPEO-DM1 linker
hu4DFabv8 (H-S122C)-BMPEO-DM1 [278]
hu4DFabv8 (H-S122C)
Receptor tyrosine-protein kinase erbB-2 (HER2)
Maytansinoid DM1
hu4DFabv8 (H-S122C)-BMPEO-DM1 linker
hu4DFabv8 (H-A175C)-BMPEO-DM1 [278]
hu4DFabv8 (H-A175C)
Receptor tyrosine-protein kinase erbB-2 (HER2)
Maytansinoid DM1
hu4DFabv8 (H-A175C)-BMPEO-DM1 linker
hu4DFabv8 (H-S179C)-BMPEO-DM1 [278]
hu4DFabv8 (H-S179C)
Receptor tyrosine-protein kinase erbB-2 (HER2)
Maytansinoid DM1
hu4DFabv8 (H-S179C)-BMPEO-DM1 linker
WO2017089890A1 ADC1 [279]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
WO2017089890A1_ADC1 linker
WO2017089890A1 ADC2 [279]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin F
WO2017089890A1_ADC2 linker
WO2017089890A1 ADC3 [279]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
WO2017089890A1_ADC3 linker
WO2017089890A1 ADC4 [279]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin F
WO2017089890A1_ADC4 linker
WO2017089890A1 ADC5 [279]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
WO2017089890A1_ADC5 linker
WO2017089890A1 ADC6 [279]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin F
WO2017089890A1_ADC6 linker
WO2017089890A1 ADC7 [279]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
WO2017089890A1_ADC7 linker
WO2017089890A1 ADC8 [279]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin F
WO2017089890A1_ADC8 linker
WO2017089890A1 ADC9 [279]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
WO2017089890A1_ADC9 linker
WO2017089890A1 ADC10 [279]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
WO2017089890A1_ADC10 linker
WO2017089890A1 ADC11 [279]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
WO2017089890A1_ADC11 linker
WO2017089890A1 ADC12 [279]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
WO2017089890A1_ADC12 linker
WO2017089890A1 ADC13 [279]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
WO2017089890A1_ADC13 linker
WO2017089890A1 ADC14 [279]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin F
WO2017089890A1_ADC14 linker
WO2017089890A1 ADC15 [279]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
WO2017089890A1_ADC15 linker
WO2017089890A1 ADC16 [279]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin F
WO2017089890A1_ADC16 linker
WO2017089890A1 ADC17 [279]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
WO2017089890A1_ADC17 linker
WO2017089890A1 ADC18 [279]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin F
WO2017089890A1_ADC18 linker
WO2017089890A1 ADC19 [279]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
WO2017089890A1_ADC19 linker
WO2017089890A1 ADC20 [279]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin F
WO2017089890A1_ADC20 linker
WO2017089890A1 ADC86 [279]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin F
WO2017089890A1_ADC86 linker
WO2017089890A1 ADC87 [279]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
WO2017089890A1_ADC87 linker
WO2017089890A1 ADC23 [279]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin F
WO2017089890A1_ADC23 linker
WO2017089890A1 ADC24 [279]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
WO2017089890A1_ADC24 linker
WO2017089890A1 ADC25 [279]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
WO2017089890A1_ADC25 linker
WO2017089890A1 ADC26 [279]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
WO2017089890A1_ADC26 linker
WO2017089890A1 ADC27 [279]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
WO2017089890A1_ADC27 linker
WO2017089890A1 ADC28 [279]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
WO2017089890A1_ADC28 linker
WO2017089890A1 ADC29 [279]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
WO2017089890A1_ADC29 linker
WO2017089890A1 ADC30 [279]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
WO2017089890A1_ADC30 linker
WO2017089890A1 ADC31 [279]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
WO2017089890A1_ADC31 linker
WO2017089890A1 ADC32 [279]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
WO2017089890A1_ADC32 linker
WO2017089890A1 ADC33 [279]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
WO2017089890A1_ADC33 linker
WO2017089890A1 ADC34 [279]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin F
WO2017089890A1_ADC34 linker
WO2017089890A1 ADC35 [279]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
WO2017089890A1_ADC35 linker
WO2017089890A1 ADC36 [279]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
WO2017089890A1_ADC36 linker
WO2017089890A1 ADC37 [279]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
WO2017089890A1_ADC37 linker
WO2017089890A1 ADC38 [279]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin F
WO2017089890A1_ADC38 linker
WO2017089890A1 ADC39 [279]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
WO2017089890A1_ADC39 linker
WO2017089890A1 ADC40 [279]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin F
WO2017089890A1_ADC40 linker
WO2017089890A1 ADC41 [279]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
WO2017089890A1_ADC41 linker
WO2017089890A1 ADC42 [279]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin F
WO2017089890A1_ADC42 linker
WO2017089890A1 ADC43 [279]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
WO2017089890A1_ADC43 linker
WO2017089890A1 ADC44 [279]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin F
WO2017089890A1_ADC44 linker
WO2017089890A1 ADC45 [279]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
WO2017089890A1_ADC45 linker
WO2017089890A1 ADC46 [279]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin F
WO2017089890A1_ADC46 linker
WO2017089890A1 ADC47 [279]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
WO2017089890A1_ADC47 linker
WO2017089890A1 ADC48 [279]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin F
WO2017089890A1_ADC48 linker
WO2017089890A1 ADC49 [279]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
WO2017089890A1_ADC49 linker
WO2017089890A1 ADC50 [279]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin F
WO2017089890A1_ADC50 linker
WO2017089890A1 ADC51 [279]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
WO2017089890A1_ADC51 linker
WO2017089890A1 ADC52 [279]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
WO2017089890A1_ADC52 linker
WO2017089890A1 ADC53 [279]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
WO2017089890A1_ADC53 linker
WO2017089890A1 ADC54 [279]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin F
WO2017089890A1_ADC54 linker
WO2017089890A1 ADC55 [279]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
WO2017089890A1_ADC55 linker
WO2017089890A1 ADC76 [279]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin F
WO2017089890A1_ADC76 linker
WO2017089890A1 ADC88 [279]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin F
WO2017089890A1_ADC88 linker
WO2017089890A1 ADC89 [279]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
WO2017089890A1_ADC89 linker
WO2017089890A1 ADC90 [279]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin F
WO2017089890A1_ADC90 linker
WO2017089890A1 ADC91 [279]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
WO2017089890A1_ADC91 linker
WO2017089890A1 ADC60 [279]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin F
WO2017089890A1_ADC60 linker
WO2017089890A1 ADC61 [279]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
WO2017089890A1_ADC61 linker
WO2017089890A1 ADC62 [279]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin F
WO2017089890A1_ADC62 linker
WO2017089890A1 ADC63 [279]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
WO2017089890A1_ADC63 linker
WO2017089890A1 ADC77 [279]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin F
WO2017089890A1_ADC77 linker
WO2017089890A1 ADC64 [279]
Cetuximab
Epidermal growth factor receptor (EGFR)
Monomethyl auristatin F
WO2017089890A1_ADC64 linker
WO2017089890A1 ADC65 [279]
Cetuximab
Epidermal growth factor receptor (EGFR)
Monomethyl auristatin E
WO2017089890A1_ADC65 linker
WO2017089890A1 ADC66 [279]
Cetuximab
Epidermal growth factor receptor (EGFR)
Monomethyl auristatin F
WO2017089890A1_ADC66 linker
WO2017089890A1 ADC67 [279]
Anti-CD19 mAb DI-B4
B-lymphocyte antigen CD19 (CD19)
Monomethyl auristatin F
WO2017089890A1_ADC67 linker
WO2017089890A1 ADC68 [279]
Anti-CD19 mAb DI-B4
B-lymphocyte antigen CD19 (CD19)
Monomethyl auristatin E
WO2017089890A1_ADC68 linker
WO2017089890A1 ADC69 [279]
Anti-CD19 mAb DI-B4
B-lymphocyte antigen CD19 (CD19)
Monomethyl auristatin F
WO2017089890A1_ADC69 linker
WO2017089890A1 ADC70 [279]
Rituximab
B-lymphocyte antigen CD20 (MS4A1)
Monomethyl auristatin F
WO2017089890A1_ADC70 linker
WO2017089890A1 ADC71 [279]
Rituximab
B-lymphocyte antigen CD20 (MS4A1)
Monomethyl auristatin E
WO2017089890A1_ADC71 linker
WO2017089890A1 ADC72 [279]
Rituximab
B-lymphocyte antigen CD20 (MS4A1)
Monomethyl auristatin F
WO2017089890A1_ADC72 linker
WO2017089890A1 ADC73 [279]
Depatuxizumab
Epidermal growth factor receptor (EGFR)
Monomethyl auristatin F
WO2017089890A1_ADC73 linker
WO2017089890A1 ADC74 [279]
Depatuxizumab
Epidermal growth factor receptor (EGFR)
Monomethyl auristatin E
WO2017089890A1_ADC74 linker
WO2017089890A1 ADC75 [279]
Depatuxizumab
Epidermal growth factor receptor (EGFR)
Monomethyl auristatin F
WO2017089890A1_ADC75 linker
Anti-BCMA 15B2GL-mcMMAF [280]
Anti-BCMA antibody 15B2GL
Tumor necrosis factor receptor superfamily member 17 (TNFRSF17)
Monomethyl auristatin F
Maleimido-caproyl
Anti-BCMA 15B2WT-mcMMAF [280]
Anti-BCMA antibody 15B2WT
Tumor necrosis factor receptor superfamily member 17 (TNFRSF17)
Monomethyl auristatin F
Maleimido-caproyl
Anti-BCMA I09-mcMMAF [280]
Anti-BCMA antibody I09
Tumor necrosis factor receptor superfamily member 17 (TNFRSF17)
Monomethyl auristatin F
Maleimido-caproyl
Anti-BCMA L15-mcMMAF [280]
Anti-BCMA antibody L15
Tumor necrosis factor receptor superfamily member 17 (TNFRSF17)
Monomethyl auristatin F
Maleimido-caproyl
Anti-BCMA M02-mcMMAF [280]
Anti-BCMA antibody M02
Tumor necrosis factor receptor superfamily member 17 (TNFRSF17)
Monomethyl auristatin F
Maleimido-caproyl
Anti-BCMA N22-mcMMAF [280]
Anti-BCMA antibody N22
Tumor necrosis factor receptor superfamily member 17 (TNFRSF17)
Monomethyl auristatin F
Maleimido-caproyl
Anti-BCMA P10-mcMMAF [280]
Anti-BCMA antibody P10
Tumor necrosis factor receptor superfamily member 17 (TNFRSF17)
Monomethyl auristatin F
Maleimido-caproyl
Anti-BCMA J6M0-mcMMAF [280]
Anti-BCMA antibody J6M0
Tumor necrosis factor receptor superfamily member 17 (TNFRSF17)
Monomethyl auristatin F
Maleimido-caproyl
2C3 WT-Mc-Val-Cit-PABC-MMAE [281]
Anti-CD52 mAb 2C3 WT
CAMPATH-1 antigen (CD52)
Monomethyl auristatin E
Mc-Val-Cit-PABC
2C3 A114N-Mc-Val-Cit-PABC-MMAE [281]
Anti-CD52 mAb 2C3 A114N
CAMPATH-1 antigen (CD52)
Monomethyl auristatin E
Mc-Val-Cit-PABC
2C3 Y436S-Mc-Val-Cit-PABC-MMAE [281]
Anti-CD52 mAb 2C3 Y436S
CAMPATH-1 antigen (CD52)
Monomethyl auristatin E
Mc-Val-Cit-PABC
2C3 S440N-Mc-Val-Cit-PABC-MMAE [281]
Anti-CD52 mAb 2C3 S440N
CAMPATH-1 antigen (CD52)
Monomethyl auristatin E
Mc-Val-Cit-PABC
2C3 S442N-Mc-Val-Cit-PABC-MMAE [281]
Anti-CD52 mAb 2C3 S442N
CAMPATH-1 antigen (CD52)
Monomethyl auristatin E
Mc-Val-Cit-PABC
2C3 NGT-Mc-Val-Cit-PABC-MMAE [281]
Anti-CD52 mAb 2C3 NGT
CAMPATH-1 antigen (CD52)
Monomethyl auristatin E
Mc-Val-Cit-PABC
2C3 S298N Y300S-Mc-Val-Cit-PABC-MMAE [281]
Anti-CD52 mAb 2C3 S298N Y300S
CAMPATH-1 antigen (CD52)
Monomethyl auristatin E
Mc-Val-Cit-PABC
TEM1 Clone 187 WT-Mc-Val-Cit-PABC-MMAE [281]
Anti-TEM1 mAb Clone 187 WT
Endosialin (CD248)
Monomethyl auristatin E
Mc-Val-Cit-PABC
TEM1 Clone 187 A114N-Mc-Val-Cit-PABC-MMAE [281]
Anti-TEM1 mAb Clone 187 A114N
Endosialin (CD248)
Monomethyl auristatin E
Mc-Val-Cit-PABC
HER2 WT-Mc-Val-Cit-PABC-MMAE [281]
Anti-HER2 mAb WT
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
Mc-Val-Cit-PABC
A114N-Mc-Val-Cit-PABC-MMAE [281]
Anti-HER2 mAb A114N
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
Mc-Val-Cit-PABC
NNAS-Mc-Val-Cit-PABC-MMAE [281]
Anti-HER2 mAb NNAS
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
Mc-Val-Cit-PABC
A114N NNAS-Mc-Val-Cit-PABC-MMAE [281]
Anti-HER2 mAb A114N NNAS
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
Mc-Val-Cit-PABC
HER2 S298N/T299A/Y300S-Mc-Val-Cit-PABC-MMAE [281]
Anti-HER2 mAb S298N/T299A/Y300S
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
Mc-Val-Cit-PABC
H66-Mc-Val-Cit-PABC-MMAE [281]
Anti-TRAC mAb H66
T cell receptor alpha chain constant (TRAC)
Monomethyl auristatin E
Mc-Val-Cit-PABC
H66 S298N/Y300S-Mc-Val-Cit-PABC-MMAE [281]
Anti-TRAC mAb H66 S298N/Y300S
T cell receptor alpha chain constant (TRAC)
Monomethyl auristatin E
Mc-Val-Cit-PABC
H66 S298N/T299A/Y300S-Mc-Val-Cit-PABC-MMAE [281]
Anti-TRAC mAb H66 S298N/T299A/Y300S
T cell receptor alpha chain constant (TRAC)
Monomethyl auristatin E
Mc-Val-Cit-PABC
H66 N297Q/S298N/Y300S-Mc-Val-Cit-PABC-MMAE [281]
Anti-TRAC mAb H66 N297Q/S298N/Y300S
T cell receptor alpha chain constant (TRAC)
Monomethyl auristatin E
Mc-Val-Cit-PABC
12G6 WT-Mc-Val-Cit-PABC-MMAE [281]
Anti-CD52 mAb 12G6 WT
CAMPATH-1 antigen (CD52)
Monomethyl auristatin E
Mc-Val-Cit-PABC
12G6 S298N/Y300S-Mc-Val-Cit-PABC-MMAE [281]
Anti-CD52 mAb 12G6 S298N/Y300S
CAMPATH-1 antigen (CD52)
Monomethyl auristatin E
Mc-Val-Cit-PABC
12G6 S298N/T299A/Y300S-Mc-Val-Cit-PABC-MMAE [281]
Anti-CD52 mAb 12G6 S298N/T299A/Y300S
CAMPATH-1 antigen (CD52)
Monomethyl auristatin E
Mc-Val-Cit-PABC
12G6 N297Q/S298N/Y300S-Mc-Val-Cit-PABC-MMAE [281]
Anti-CD52 mAb 12G6 N297Q/S298N/Y300S
CAMPATH-1 antigen (CD52)
Monomethyl auristatin E
Mc-Val-Cit-PABC
Anti-HER-AO-Cys-MC-VC-PABC-MMAE [281]
Anti-HER2 mAb WT
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
Anti-HER-AO-Cys-MC-VC-PABC-MMAE linker
Anti-FAP B11-MC-VC-PABC-MMAE [281]
Anti-FAP mAb B11
Prolyl endopeptidase FAP (FAP)
Monomethyl auristatin E
Anti-FAP B11-MC-VC-PABC-MMAE linker
Anti-FAP B11-AO-Cys-MC-VC-PABC-MMAE [281]
Anti-FAP mAb B11
Prolyl endopeptidase FAP (FAP)
Monomethyl auristatin E
Anti-FAP B11-AO-Cys-MC-VC-PABC-MMAE linker
huPr1-vcMMAE [282]
Anti-TMEFF2 mAb huPr1
Tomoregulin-2 (TMEFF2)
Monomethyl auristatin E
Mc-Val-Cit-PABC
WO2015177360A1 ADC-wt-vcMMAE [283]
Anti-PSMA mAb wt
Glutamate carboxypeptidase 2 (FOLH1)
Monomethyl auristatin E
Mc-Val-Cit-PABC
WO2015177360A1 ADC-HC41-vcMMAE [283]
Anti-PSMA mAb wt HC S41C
Glutamate carboxypeptidase 2 (FOLH1)
Monomethyl auristatin E
Mc-Val-Cit-PABC
WO2015177360A1 ADC-LC40-vcMMAE [283]
Anti-PSMA mAb wt LC P40C
Glutamate carboxypeptidase 2 (FOLH1)
Monomethyl auristatin E
Mc-Val-Cit-PABC
WO2015177360A1 ADC-LC41-vcMMAE [283]
Anti-PSMA mAb wt LC G41C
Glutamate carboxypeptidase 2 (FOLH1)
Monomethyl auristatin E
Mc-Val-Cit-PABC
WO2015177360A1 ADC-H8-HC40-vcMMAE [283]
Anti-5T4 mAb H8 S40C
Trophoblast glycoprotein (TPBG)
Monomethyl auristatin E
Mc-Val-Cit-PABC
WO2015177360A1 ADC-wt-mcMMAF [283]
Anti-PSMA mAb wt
Glutamate carboxypeptidase 2 (FOLH1)
Monomethyl auristatin F
Maleimido-caproyl
WO2015177360A1 ADC-HC41-mcMMAF [283]
Anti-PSMA mAb wt HC S41C
Glutamate carboxypeptidase 2 (FOLH1)
Monomethyl auristatin F
Maleimido-caproyl
WO2015177360A1 ADC-LC40-mcMMAF [283]
Anti-PSMA mAb wt LC P40C
Glutamate carboxypeptidase 2 (FOLH1)
Monomethyl auristatin F
Maleimido-caproyl
WO2015177360A1 ADC-LC41-mcMMAF [283]
Anti-PSMA mAb wt LC G41C
Glutamate carboxypeptidase 2 (FOLH1)
Monomethyl auristatin F
Maleimido-caproyl
WO2015177360A1 ADC-H8-wt-mcMMAF [283]
Anti-5T4 mAb H8 wt
Trophoblast glycoprotein (TPBG)
Monomethyl auristatin F
Maleimido-caproyl
WO2015177360A1 ADC-H8-HC40-mcMMAF [283]
Anti-5T4 mAb H8 S40C
Trophoblast glycoprotein (TPBG)
Monomethyl auristatin F
Maleimido-caproyl
h3G10.A57-h3G10 vcMMAD [284]
h3G10.A57-h3G10
C-X-C chemokine receptor type 4 (CXCR4)
Monomethyl auristatin D
Mc-Val-Cit-PABC
h3G10.A57-h3G10 vc0101 [284]
h3G10.A57-h3G10
C-X-C chemokine receptor type 4 (CXCR4)
Auristatin 0101
Mc-Val-Cit-PABC
h3G10.A57-h3G10.2.72 vcMMAD [284]
h3G10.A57-h3G10.2.72
C-X-C chemokine receptor type 4 (CXCR4)
Monomethyl auristatin D
Mc-Val-Cit-PABC
h3G10.A57-h3G10.2.72 vc0101 [284]
h3G10.A57-h3G10.2.72
C-X-C chemokine receptor type 4 (CXCR4)
Auristatin 0101
Mc-Val-Cit-PABC
h3G10.1.91-h3G10.2.72 vcMMAD [284]
h3G10.1.91-h3G10.2.72
C-X-C chemokine receptor type 4 (CXCR4)
Monomethyl auristatin D
Mc-Val-Cit-PABC
h3G10.1.91-h3G10.2.72 vc0101 [284]
h3G10.1.91-h3G10.2.72
C-X-C chemokine receptor type 4 (CXCR4)
Auristatin 0101
Mc-Val-Cit-PABC
h3G10.2.37-h3G10.2.72 vcMMAD [284]
h3G10.2.37-h3G10.2.72
C-X-C chemokine receptor type 4 (CXCR4)
Monomethyl auristatin D
Mc-Val-Cit-PABC
h3G10.2.37-h3G10.2.72 vc0101 [284]
h3G10.2.37-h3G10.2.72
C-X-C chemokine receptor type 4 (CXCR4)
Auristatin 0101
Mc-Val-Cit-PABC
H3G10.A57-h3G10.A58 vcMMAD [284]
h3G10.A57-h3G10.A58
C-X-C chemokine receptor type 4 (CXCR4)
Monomethyl auristatin D
Mc-Val-Cit-PABC
H3G10.A57-h3G10.A58 vc0101 [284]
h3G10.A57-h3G10.A58
C-X-C chemokine receptor type 4 (CXCR4)
Auristatin 0101
Mc-Val-Cit-PABC
H3G10.1.91-h3G10.A58 vcMMAD [284]
h3G10.1.91-h3G10.A58
C-X-C chemokine receptor type 4 (CXCR4)
Monomethyl auristatin D
Mc-Val-Cit-PABC
H3G10.1.91-h3G10.A58 vc0101 [284]
h3G10.1.91-h3G10.A58
C-X-C chemokine receptor type 4 (CXCR4)
Auristatin 0101
Mc-Val-Cit-PABC
H3G10.2.37-h3G10.A58 vcMMAD [284]
h3G10.2.37-h3G10.A58
C-X-C chemokine receptor type 4 (CXCR4)
Monomethyl auristatin D
Mc-Val-Cit-PABC
H3G10.2.37-h3G10.A58 vc0101 [284]
h3G10.2.37-h3G10.A58
C-X-C chemokine receptor type 4 (CXCR4)
Auristatin 0101
Mc-Val-Cit-PABC
H3G10.A57-h3G10.A58 vcMMAD [284]
h3G10.A57-h3G10.A58
C-X-C chemokine receptor type 4 (CXCR4)
Monomethyl auristatin D
Mc-Val-Cit-PABC
H3G10.A57-h3G10.A58 vc0101 [284]
h3G10.A57-h3G10.A58
C-X-C chemokine receptor type 4 (CXCR4)
Auristatin 0101
Mc-Val-Cit-PABC
H3G10.1.91-h3G10.A58 vcMMAD [284]
h3G10.1.91-h3G10.A58
C-X-C chemokine receptor type 4 (CXCR4)
Monomethyl auristatin D
Mc-Val-Cit-PABC
H3G10.1.91-h3G10.A58 vc0101 [284]
h3G10.1.91-h3G10.A58
C-X-C chemokine receptor type 4 (CXCR4)
Auristatin 0101
Mc-Val-Cit-PABC
H3G10.2.37-h3G10.A58 vcMMAD [284]
h3G10.2.37-h3G10.A58
C-X-C chemokine receptor type 4 (CXCR4)
Monomethyl auristatin D
Mc-Val-Cit-PABC
H3G10.2.37-h3G10.A58 vc0101 [284]
h3G10.2.37-h3G10.A58
C-X-C chemokine receptor type 4 (CXCR4)
Auristatin 0101
Mc-Val-Cit-PABC
3G10-TG6-vcMMAD [284]
3G10-TG6
C-X-C chemokine receptor type 4 (CXCR4)
Monomethyl auristatin D
Mc-Val-Cit-PABC
6B6-TG6-vcMMAD [284]
6B6-TG6
C-X-C chemokine receptor type 4 (CXCR4)
Monomethyl auristatin D
Mc-Val-Cit-PABC
12A11-TG6-vcMMAD [284]
12A11-TG6
C-X-C chemokine receptor type 4 (CXCR4)
Monomethyl auristatin D
Mc-Val-Cit-PABC
3G10-TG6-vc0101 [284]
3G10-TG6
C-X-C chemokine receptor type 4 (CXCR4)
Auristatin 0101
Mc-Val-Cit-PABC
6B6-TG6-vc0101 [284]
6B6-TG6
C-X-C chemokine receptor type 4 (CXCR4)
Auristatin 0101
Mc-Val-Cit-PABC
Trastuzumab-Compound 9 [285]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Mertansine DM1
Trastuzumab-Compound 9 linker
Pertuzumab-Compound 9 [285]
Pertuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Mertansine DM1
Pertuzumab-Compound 9 linker
Rituximab-Compound 9 [285]
Rituximab
B-lymphocyte antigen CD20 (MS4A1)
Mertansine DM1
Rituximab-Compound 9 linker
Alemtuzumab-Compound 9 [285]
Alemtuzumab
CAMPATH-1 antigen (CD52)
Mertansine DM1
Alemtuzumab-Compound 9 linker
Bevacizumab-Compound 9 [285]
Bevacizumab
Vascular endothelial growth factor A (VEGFA)
Mertansine DM1
Bevacizumab-Compound 9 linker
Adalimumab-Compound 9 [285]
Adalimumab
Tumor necrosis factor (TNF)
Mertansine DM1
Adalimumab-Compound 9 linker
Cetuximab-Compound 9 [285]
Cetuximab
Epidermal growth factor receptor (EGFR)
Mertansine DM1
Cetuximab-Compound 9 linker
Amatuximab-Compound 9 [285]
Amatuximab
Mesothelin (MSLN)
Mertansine DM1
Amatuximab-Compound 9 linker
Blinatumomab-Compound 9 [285]
Blinatumomab
B-lymphocyte antigen CD19 (CD19); T-cell surface glycoprotein CD3 delta chain (CD3D)
Mertansine DM1
Blinatumomab-Compound 9 linker
Brentuximab-Compound 9 [285]
Brentuximab
Tumor necrosis factor receptor superfamily member 8 (TNFRSF8)
Mertansine DM1
Brentuximab-Compound 9 linker
Sacituzumab-Compound 9 [285]
Sacituzumab
Tumor-associated calcium signal transducer 2 (TACSTD2)
Mertansine DM1
Sacituzumab-Compound 9 linker
Panitumumab-Compound 9 [285]
Panitumumab
Epidermal growth factor receptor (EGFR)
Mertansine DM1
Panitumumab-Compound 9 linker
Nimotuzumab-Compound 9 [285]
Nimotuzumab
Epidermal growth factor receptor (EGFR)
Mertansine DM1
Nimotuzumab-Compound 9 linker
Gemtuzumab-Compound 9 [285]
Gemtuzumab
Myeloid cell surface antigen CD33 (CD33)
Mertansine DM1
Gemtuzumab-Compound 9 linker
Golimumab-Compound 9 [285]
Golimumab
Tumor necrosis factor (TNF)
Mertansine DM1
Golimumab-Compound 9 linker
Ibritumomab-Compound 9 [285]
Ibritumomab
B-lymphocyte antigen CD20 (MS4A1)
Mertansine DM1
Ibritumomab-Compound 9 linker
Infliximab-Compound 9 [285]
Infliximab
Tumor necrosis factor (TNF)
Mertansine DM1
Infliximab-Compound 9 linker
Ipilimumab-Compound 9 [285]
Ipilimumab
Cytotoxic T-lymphocyte protein 4 (CTLA4)
Mertansine DM1
Ipilimumab-Compound 9 linker
Ofatumumab-Compound 9 [285]
Ofatumumab
B-lymphocyte antigen CD20 (MS4A1)
Mertansine DM1
Ofatumumab-Compound 9 linker
Tositumomab-Compound 9 [285]
Tositumomab
B-lymphocyte antigen CD20 (MS4A1)
Mertansine DM1
Tositumomab-Compound 9 linker
Trastuzumab-Compound 17 [285]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Mertansine DM4
Trastuzumab-Compound 17 linker
Pertuzumab-Compound 17 [285]
Pertuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Mertansine DM4
Pertuzumab-Compound 17 linker
Rituximab-Compound 17 [285]
Rituximab
B-lymphocyte antigen CD20 (MS4A1)
Mertansine DM4
Rituximab-Compound 17 linker
Alemtuzumab-Compound 17 [285]
Alemtuzumab
CAMPATH-1 antigen (CD52)
Mertansine DM4
Alemtuzumab-Compound 17 linker
Bevacizumab-Compound 17 [285]
Bevacizumab
Vascular endothelial growth factor A (VEGFA)
Mertansine DM4
Bevacizumab-Compound 17 linker
Adalimumab-Compound 17 [285]
Adalimumab
Tumor necrosis factor (TNF)
Mertansine DM4
Adalimumab-Compound 17 linker
Cetuximab-Compound 17 [285]
Cetuximab
Epidermal growth factor receptor (EGFR)
Mertansine DM4
Cetuximab-Compound 17 linker
Amatuximab-Compound 17 [285]
Amatuximab
Mesothelin (MSLN)
Mertansine DM4
Amatuximab-Compound 17 linker
Blinatumomab-Compound 17 [285]
Blinatumomab
B-lymphocyte antigen CD19 (CD19); T-cell surface glycoprotein CD3 delta chain (CD3D)
Mertansine DM4
Blinatumomab-Compound 17 linker
Brentuximab-Compound 17 [285]
Brentuximab
Tumor necrosis factor receptor superfamily member 8 (TNFRSF8)
Mertansine DM4
Brentuximab-Compound 17 linker
Sacituzumab-Compound 17 [285]
Sacituzumab
Tumor-associated calcium signal transducer 2 (TACSTD2)
Mertansine DM4
Sacituzumab-Compound 17 linker
Panitumumab-Compound 17 [285]
Panitumumab
Epidermal growth factor receptor (EGFR)
Mertansine DM4
Panitumumab-Compound 17 linker
Nimotuzumab-Compound 17 [285]
Nimotuzumab
Epidermal growth factor receptor (EGFR)
Mertansine DM4
Nimotuzumab-Compound 17 linker
Gemtuzumab-Compound 17 [285]
Gemtuzumab
Myeloid cell surface antigen CD33 (CD33)
Mertansine DM4
Gemtuzumab-Compound 17 linker
Golimumab-Compound 17 [285]
Golimumab
Tumor necrosis factor (TNF)
Mertansine DM4
Golimumab-Compound 17 linker
Ibritumomab-Compound 17 [285]
Ibritumomab
B-lymphocyte antigen CD20 (MS4A1)
Mertansine DM4
Ibritumomab-Compound 17 linker
Infliximab-Compound 17 [285]
Infliximab
Tumor necrosis factor (TNF)
Mertansine DM4
Infliximab-Compound 17 linker
Ipilimumab-Compound 17 [285]
Ipilimumab
Cytotoxic T-lymphocyte protein 4 (CTLA4)
Mertansine DM4
Ipilimumab-Compound 17 linker
Ofatumumab-Compound 17 [285]
Ofatumumab
B-lymphocyte antigen CD20 (MS4A1)
Mertansine DM4
Ofatumumab-Compound 17 linker
Tositumomab-Compound 17 [285]
Tositumomab
B-lymphocyte antigen CD20 (MS4A1)
Mertansine DM4
Tositumomab-Compound 17 linker
Trastuzumab-Compound 25 [285]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
Trastuzumab-Compound 25 linker
Pertuzumab-Compound 25 [285]
Pertuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
Pertuzumab-Compound 25 linker
Rituximab-Compound 25 [285]
Rituximab
B-lymphocyte antigen CD20 (MS4A1)
Monomethyl auristatin E
Rituximab-Compound 25 linker
Alemtuzumab-Compound 25 [285]
Alemtuzumab
CAMPATH-1 antigen (CD52)
Monomethyl auristatin E
Alemtuzumab-Compound 25 linker
Bevacizumab-Compound 25 [285]
Bevacizumab
Vascular endothelial growth factor A (VEGFA)
Monomethyl auristatin E
Bevacizumab-Compound 25 linker
Adalimumab-Compound 25 [285]
Adalimumab
Tumor necrosis factor (TNF)
Monomethyl auristatin E
Adalimumab-Compound 25 linker
Cetuximab-Compound 25 [285]
Cetuximab
Epidermal growth factor receptor (EGFR)
Monomethyl auristatin E
Cetuximab-Compound 25 linker
Amatuximab-Compound 25 [285]
Amatuximab
Mesothelin (MSLN)
Monomethyl auristatin E
Amatuximab-Compound 25 linker
Blinatumomab-Compound 25 [285]
Blinatumomab
B-lymphocyte antigen CD19 (CD19); T-cell surface glycoprotein CD3 delta chain (CD3D)
Monomethyl auristatin E
Blinatumomab-Compound 25 linker
Brentuximab-Compound 25 [285]
Brentuximab
Tumor necrosis factor receptor superfamily member 8 (TNFRSF8)
Monomethyl auristatin E
Brentuximab-Compound 25 linker
Sacituzumab-Compound 25 [285]
Sacituzumab
Tumor-associated calcium signal transducer 2 (TACSTD2)
Monomethyl auristatin E
Sacituzumab-Compound 25 linker
Panitumumab-Compound 25 [285]
Panitumumab
Epidermal growth factor receptor (EGFR)
Monomethyl auristatin E
Panitumumab-Compound 25 linker
Nimotuzumab-Compound 25 [285]
Nimotuzumab
Epidermal growth factor receptor (EGFR)
Monomethyl auristatin E
Nimotuzumab-Compound 25 linker
Gemtuzumab-Compound 25 [285]
Gemtuzumab
Myeloid cell surface antigen CD33 (CD33)
Monomethyl auristatin E
Gemtuzumab-Compound 25 linker
Golimumab-Compound 25 [285]
Golimumab
Tumor necrosis factor (TNF)
Monomethyl auristatin E
Golimumab-Compound 25 linker
Ibritumomab-Compound 25 [285]
Ibritumomab
B-lymphocyte antigen CD20 (MS4A1)
Monomethyl auristatin E
Ibritumomab-Compound 25 linker
Infliximab-Compound 25 [285]
Infliximab
Tumor necrosis factor (TNF)
Monomethyl auristatin E
Infliximab-Compound 25 linker
Ipilimumab-Compound 25 [285]
Ipilimumab
Cytotoxic T-lymphocyte protein 4 (CTLA4)
Monomethyl auristatin E
Ipilimumab-Compound 25 linker
Ofatumumab-Compound 25 [285]
Ofatumumab
B-lymphocyte antigen CD20 (MS4A1)
Monomethyl auristatin E
Ofatumumab-Compound 25 linker
Tositumomab-Compound 25 [285]
Tositumomab
B-lymphocyte antigen CD20 (MS4A1)
Monomethyl auristatin E
Tositumomab-Compound 25 linker
Trastuzumab-Compound 31 [285]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Auristatin 0101
Trastuzumab-Compound 31 linker
Pertuzumab-Compound 31 [285]
Pertuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Auristatin 0101
Pertuzumab-Compound 31 linker
Rituximab-Compound 31 [285]
Rituximab
B-lymphocyte antigen CD20 (MS4A1)
Auristatin 0101
Rituximab-Compound 31 linker
Alemtuzumab-Compound 31 [285]
Alemtuzumab
CAMPATH-1 antigen (CD52)
Auristatin 0101
Alemtuzumab-Compound 31 linker
Bevacizumab-Compound 31 [285]
Bevacizumab
Vascular endothelial growth factor A (VEGFA)
Auristatin 0101
Bevacizumab-Compound 31 linker
Adalimumab-Compound 31 [285]
Adalimumab
Tumor necrosis factor (TNF)
Auristatin 0101
Adalimumab-Compound 31 linker
Cetuximab-Compound 31 [285]
Cetuximab
Epidermal growth factor receptor (EGFR)
Auristatin 0101
Cetuximab-Compound 31 linker
Amatuximab-Compound 31 [285]
Amatuximab
Mesothelin (MSLN)
Auristatin 0101
Amatuximab-Compound 31 linker
Blinatumomab-Compound 31 [285]
Blinatumomab
B-lymphocyte antigen CD19 (CD19); T-cell surface glycoprotein CD3 delta chain (CD3D)
Auristatin 0101
Blinatumomab-Compound 31 linker
Brentuximab-Compound 31 [285]
Brentuximab
Tumor necrosis factor receptor superfamily member 8 (TNFRSF8)
Auristatin 0101
Brentuximab-Compound 31 linker
Sacituzumab-Compound 31 [285]
Sacituzumab
Tumor-associated calcium signal transducer 2 (TACSTD2)
Auristatin 0101
Sacituzumab-Compound 31 linker
Panitumumab-Compound 31 [285]
Panitumumab
Epidermal growth factor receptor (EGFR)
Auristatin 0101
Panitumumab-Compound 31 linker
Nimotuzumab-Compound 31 [285]
Nimotuzumab
Epidermal growth factor receptor (EGFR)
Auristatin 0101
Nimotuzumab-Compound 31 linker
Gemtuzumab-Compound 31 [285]
Gemtuzumab
Myeloid cell surface antigen CD33 (CD33)
Auristatin 0101
Gemtuzumab-Compound 31 linker
Golimumab-Compound 31 [285]
Golimumab
Tumor necrosis factor (TNF)
Auristatin 0101
Golimumab-Compound 31 linker
Ibritumomab-Compound 31 [285]
Ibritumomab
B-lymphocyte antigen CD20 (MS4A1)
Auristatin 0101
Ibritumomab-Compound 31 linker
Infliximab-Compound 31 [285]
Infliximab
Tumor necrosis factor (TNF)
Auristatin 0101
Infliximab-Compound 31 linker
Ipilimumab-Compound 31 [285]
Ipilimumab
Cytotoxic T-lymphocyte protein 4 (CTLA4)
Auristatin 0101
Ipilimumab-Compound 31 linker
Ofatumumab-Compound 31 [285]
Ofatumumab
B-lymphocyte antigen CD20 (MS4A1)
Auristatin 0101
Ofatumumab-Compound 31 linker
Tositumomab-Compound 31 [285]
Tositumomab
B-lymphocyte antigen CD20 (MS4A1)
Auristatin 0101
Tositumomab-Compound 31 linker
Trastuzumab-Compound 36 [285]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
Trastuzumab-Compound 36 linker
Pertuzumab-Compound 36 [285]
Pertuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
Pertuzumab-Compound 36 linker
Rituximab-Compound 36 [285]
Rituximab
B-lymphocyte antigen CD20 (MS4A1)
Monomethyl auristatin E
Rituximab-Compound 36 linker
Alemtuzumab-Compound 36 [285]
Alemtuzumab
CAMPATH-1 antigen (CD52)
Monomethyl auristatin E
Alemtuzumab-Compound 36 linker
Bevacizumab-Compound 36 [285]
Bevacizumab
Vascular endothelial growth factor A (VEGFA)
Monomethyl auristatin E
Bevacizumab-Compound 36 linker
Adalimumab-Compound 36 [285]
Adalimumab
Tumor necrosis factor (TNF)
Monomethyl auristatin E
Adalimumab-Compound 36 linker
Cetuximab-Compound 36 [285]
Cetuximab
Epidermal growth factor receptor (EGFR)
Monomethyl auristatin E
Cetuximab-Compound 36 linker
Amatuximab-Compound 36 [285]
Amatuximab
Mesothelin (MSLN)
Monomethyl auristatin E
Amatuximab-Compound 36 linker
Blinatumomab-Compound 36 [285]
Blinatumomab
B-lymphocyte antigen CD19 (CD19); T-cell surface glycoprotein CD3 delta chain (CD3D)
Monomethyl auristatin E
Blinatumomab-Compound 36 linker
Brentuximab-Compound 36 [285]
Brentuximab
Tumor necrosis factor receptor superfamily member 8 (TNFRSF8)
Monomethyl auristatin E
Brentuximab-Compound 36 linker
Sacituzumab-Compound 36 [285]
Sacituzumab
Tumor-associated calcium signal transducer 2 (TACSTD2)
Monomethyl auristatin E
Sacituzumab-Compound 36 linker
Panitumumab-Compound 36 [285]
Panitumumab
Epidermal growth factor receptor (EGFR)
Monomethyl auristatin E
Panitumumab-Compound 36 linker
Nimotuzumab-Compound 36 [285]
Nimotuzumab
Epidermal growth factor receptor (EGFR)
Monomethyl auristatin E
Nimotuzumab-Compound 36 linker
Gemtuzumab-Compound 36 [285]
Gemtuzumab
Myeloid cell surface antigen CD33 (CD33)
Monomethyl auristatin E
Gemtuzumab-Compound 36 linker
Golimumab-Compound 36 [285]
Golimumab
Tumor necrosis factor (TNF)
Monomethyl auristatin E
Golimumab-Compound 36 linker
Ibritumomab-Compound 36 [285]
Ibritumomab
B-lymphocyte antigen CD20 (MS4A1)
Monomethyl auristatin E
Ibritumomab-Compound 36 linker
Infliximab-Compound 36 [285]
Infliximab
Tumor necrosis factor (TNF)
Monomethyl auristatin E
Infliximab-Compound 36 linker
Ipilimumab-Compound 36 [285]
Ipilimumab
Cytotoxic T-lymphocyte protein 4 (CTLA4)
Monomethyl auristatin E
Ipilimumab-Compound 36 linker
Ofatumumab-Compound 36 [285]
Ofatumumab
B-lymphocyte antigen CD20 (MS4A1)
Monomethyl auristatin E
Ofatumumab-Compound 36 linker
Tositumomab-Compound 36 [285]
Tositumomab
B-lymphocyte antigen CD20 (MS4A1)
Monomethyl auristatin E
Tositumomab-Compound 36 linker
Trastuzumab-Compound 55 [285]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Mertansine DM1
Trastuzumab-Compound 55 linker
Pertuzumab-Compound 55 [285]
Pertuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Mertansine DM1
Pertuzumab-Compound 55 linker
Rituximab-Compound 55 [285]
Rituximab
B-lymphocyte antigen CD20 (MS4A1)
Mertansine DM1
Rituximab-Compound 55 linker
Alemtuzumab-Compound 55 [285]
Alemtuzumab
CAMPATH-1 antigen (CD52)
Mertansine DM1
Alemtuzumab-Compound 55 linker
Bevacizumab-Compound 55 [285]
Bevacizumab
Vascular endothelial growth factor A (VEGFA)
Mertansine DM1
Bevacizumab-Compound 55 linker
Adalimumab-Compound 55 [285]
Adalimumab
Tumor necrosis factor (TNF)
Mertansine DM1
Adalimumab-Compound 55 linker
Cetuximab-Compound 55 [285]
Cetuximab
Epidermal growth factor receptor (EGFR)
Mertansine DM1
Cetuximab-Compound 55 linker
Amatuximab-Compound 55 [285]
Amatuximab
Mesothelin (MSLN)
Mertansine DM1
Amatuximab-Compound 55 linker
Blinatumomab-Compound 55 [285]
Blinatumomab
B-lymphocyte antigen CD19 (CD19); T-cell surface glycoprotein CD3 delta chain (CD3D)
Mertansine DM1
Blinatumomab-Compound 55 linker
Brentuximab-Compound 55 [285]
Brentuximab
Tumor necrosis factor receptor superfamily member 8 (TNFRSF8)
Mertansine DM1
Brentuximab-Compound 55 linker
Sacituzumab-Compound 55 [285]
Sacituzumab
Tumor-associated calcium signal transducer 2 (TACSTD2)
Mertansine DM1
Sacituzumab-Compound 55 linker
Panitumumab-Compound 55 [285]
Panitumumab
Epidermal growth factor receptor (EGFR)
Mertansine DM1
Panitumumab-Compound 55 linker
Nimotuzumab-Compound 55 [285]
Nimotuzumab
Epidermal growth factor receptor (EGFR)
Mertansine DM1
Nimotuzumab-Compound 55 linker
Gemtuzumab-Compound 55 [285]
Gemtuzumab
Myeloid cell surface antigen CD33 (CD33)
Mertansine DM1
Gemtuzumab-Compound 55 linker
Golimumab-Compound 55 [285]
Golimumab
Tumor necrosis factor (TNF)
Mertansine DM1
Golimumab-Compound 55 linker
Ibritumomab-Compound 55 [285]
Ibritumomab
B-lymphocyte antigen CD20 (MS4A1)
Mertansine DM1
Ibritumomab-Compound 55 linker
Infliximab-Compound 55 [285]
Infliximab
Tumor necrosis factor (TNF)
Mertansine DM1
Infliximab-Compound 55 linker
Ipilimumab-Compound 55 [285]
Ipilimumab
Cytotoxic T-lymphocyte protein 4 (CTLA4)
Mertansine DM1
Ipilimumab-Compound 55 linker
Ofatumumab-Compound 55 [285]
Ofatumumab
B-lymphocyte antigen CD20 (MS4A1)
Mertansine DM1
Ofatumumab-Compound 55 linker
Tositumomab-Compound 55 [285]
Tositumomab
B-lymphocyte antigen CD20 (MS4A1)
Mertansine DM1
Tositumomab-Compound 55 linker
Trastuzumab-Compound 59 [285]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Mertansine DM4
Trastuzumab-Compound 59 linker
Pertuzumab-Compound 59 [285]
Pertuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Mertansine DM4
Pertuzumab-Compound 59 linker
Rituximab-Compound 59 [285]
Rituximab
B-lymphocyte antigen CD20 (MS4A1)
Mertansine DM4
Rituximab-Compound 59 linker
Alemtuzumab-Compound 59 [285]
Alemtuzumab
CAMPATH-1 antigen (CD52)
Mertansine DM4
Alemtuzumab-Compound 59 linker
Bevacizumab-Compound 59 [285]
Bevacizumab
Vascular endothelial growth factor A (VEGFA)
Mertansine DM4
Bevacizumab-Compound 59 linker
Adalimumab-Compound 59 [285]
Adalimumab
Tumor necrosis factor (TNF)
Mertansine DM4
Adalimumab-Compound 59 linker
Cetuximab-Compound 59 [285]
Cetuximab
Epidermal growth factor receptor (EGFR)
Mertansine DM4
Cetuximab-Compound 59 linker
Amatuximab-Compound 59 [285]
Amatuximab
Mesothelin (MSLN)
Mertansine DM4
Amatuximab-Compound 59 linker
Blinatumomab-Compound 59 [285]
Blinatumomab
B-lymphocyte antigen CD19 (CD19); T-cell surface glycoprotein CD3 delta chain (CD3D)
Mertansine DM4
Blinatumomab-Compound 59 linker
Brentuximab-Compound 59 [285]
Brentuximab
Tumor necrosis factor receptor superfamily member 8 (TNFRSF8)
Mertansine DM4
Brentuximab-Compound 59 linker
Sacituzumab-Compound 59 [285]
Sacituzumab
Tumor-associated calcium signal transducer 2 (TACSTD2)
Mertansine DM4
Sacituzumab-Compound 59 linker
Panitumumab-Compound 59 [285]
Panitumumab
Epidermal growth factor receptor (EGFR)
Mertansine DM4
Panitumumab-Compound 59 linker
Nimotuzumab-Compound 59 [285]
Nimotuzumab
Epidermal growth factor receptor (EGFR)
Mertansine DM4
Nimotuzumab-Compound 59 linker
Gemtuzumab-Compound 59 [285]
Gemtuzumab
Myeloid cell surface antigen CD33 (CD33)
Mertansine DM4
Gemtuzumab-Compound 59 linker
Golimumab-Compound 59 [285]
Golimumab
Tumor necrosis factor (TNF)
Mertansine DM4
Golimumab-Compound 59 linker
Ibritumomab-Compound 59 [285]
Ibritumomab
B-lymphocyte antigen CD20 (MS4A1)
Mertansine DM4
Ibritumomab-Compound 59 linker
Infliximab-Compound 59 [285]
Infliximab
Tumor necrosis factor (TNF)
Mertansine DM4
Infliximab-Compound 59 linker
Ipilimumab-Compound 59 [285]
Ipilimumab
Cytotoxic T-lymphocyte protein 4 (CTLA4)
Mertansine DM4
Ipilimumab-Compound 59 linker
Ofatumumab-Compound 59 [285]
Ofatumumab
B-lymphocyte antigen CD20 (MS4A1)
Mertansine DM4
Ofatumumab-Compound 59 linker
Tositumomab-Compound 59 [285]
Tositumomab
B-lymphocyte antigen CD20 (MS4A1)
Mertansine DM4
Tositumomab-Compound 59 linker
Trastuzumab-Compound 64 [285]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
Trastuzumab-Compound 64 linker
Pertuzumab-Compound 64 [285]
Pertuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
Pertuzumab-Compound 64 linker
Rituximab-Compound 64 [285]
Rituximab
B-lymphocyte antigen CD20 (MS4A1)
Monomethyl auristatin E
Rituximab-Compound 64 linker
Alemtuzumab-Compound 64 [285]
Alemtuzumab
CAMPATH-1 antigen (CD52)
Monomethyl auristatin E
Alemtuzumab-Compound 64 linker
Bevacizumab-Compound 64 [285]
Bevacizumab
Vascular endothelial growth factor A (VEGFA)
Monomethyl auristatin E
Bevacizumab-Compound 64 linker
Adalimumab-Compound 64 [285]
Adalimumab
Tumor necrosis factor (TNF)
Monomethyl auristatin E
Adalimumab-Compound 64 linker
Cetuximab-Compound 64 [285]
Cetuximab
Epidermal growth factor receptor (EGFR)
Monomethyl auristatin E
Cetuximab-Compound 64 linker
Amatuximab-Compound 64 [285]
Amatuximab
Mesothelin (MSLN)
Monomethyl auristatin E
Amatuximab-Compound 64 linker
Blinatumomab-Compound 64 [285]
Blinatumomab
B-lymphocyte antigen CD19 (CD19); T-cell surface glycoprotein CD3 delta chain (CD3D)
Monomethyl auristatin E
Blinatumomab-Compound 64 linker
Brentuximab-Compound 64 [285]
Brentuximab
Tumor necrosis factor receptor superfamily member 8 (TNFRSF8)
Monomethyl auristatin E
Brentuximab-Compound 64 linker
Sacituzumab-Compound 64 [285]
Sacituzumab
Tumor-associated calcium signal transducer 2 (TACSTD2)
Monomethyl auristatin E
Sacituzumab-Compound 64 linker
Panitumumab-Compound 64 [285]
Panitumumab
Epidermal growth factor receptor (EGFR)
Monomethyl auristatin E
Panitumumab-Compound 64 linker
Nimotuzumab-Compound 64 [285]
Nimotuzumab
Epidermal growth factor receptor (EGFR)
Monomethyl auristatin E
Nimotuzumab-Compound 64 linker
Gemtuzumab-Compound 64 [285]
Gemtuzumab
Myeloid cell surface antigen CD33 (CD33)
Monomethyl auristatin E
Gemtuzumab-Compound 64 linker
Golimumab-Compound 64 [285]
Golimumab
Tumor necrosis factor (TNF)
Monomethyl auristatin E
Golimumab-Compound 64 linker
Ibritumomab-Compound 64 [285]
Ibritumomab
B-lymphocyte antigen CD20 (MS4A1)
Monomethyl auristatin E
Ibritumomab-Compound 64 linker
Infliximab-Compound 64 [285]
Infliximab
Tumor necrosis factor (TNF)
Monomethyl auristatin E
Infliximab-Compound 64 linker
Ipilimumab-Compound 64 [285]
Ipilimumab
Cytotoxic T-lymphocyte protein 4 (CTLA4)
Monomethyl auristatin E
Ipilimumab-Compound 64 linker
Ofatumumab-Compound 64 [285]
Ofatumumab
B-lymphocyte antigen CD20 (MS4A1)
Monomethyl auristatin E
Ofatumumab-Compound 64 linker
Tositumomab-Compound 64 [285]
Tositumomab
B-lymphocyte antigen CD20 (MS4A1)
Monomethyl auristatin E
Tositumomab-Compound 64 linker
Trastuzumab-Compound 69 [285]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
Trastuzumab-Compound 69 linker
Pertuzumab-Compound 69 [285]
Pertuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
Pertuzumab-Compound 69 linker
Rituximab-Compound 69 [285]
Rituximab
B-lymphocyte antigen CD20 (MS4A1)
Monomethyl auristatin E
Rituximab-Compound 69 linker
Alemtuzumab-Compound 69 [285]
Alemtuzumab
CAMPATH-1 antigen (CD52)
Monomethyl auristatin E
Alemtuzumab-Compound 69 linker
Bevacizumab-Compound 69 [285]
Bevacizumab
Vascular endothelial growth factor A (VEGFA)
Monomethyl auristatin E
Bevacizumab-Compound 69 linker
Adalimumab-Compound 69 [285]
Adalimumab
Tumor necrosis factor (TNF)
Monomethyl auristatin E
Adalimumab-Compound 69 linker
Cetuximab-Compound 69 [285]
Cetuximab
Epidermal growth factor receptor (EGFR)
Monomethyl auristatin E
Cetuximab-Compound 69 linker
Amatuximab-Compound 69 [285]
Amatuximab
Mesothelin (MSLN)
Monomethyl auristatin E
Amatuximab-Compound 69 linker
Blinatumomab-Compound 69 [285]
Blinatumomab
B-lymphocyte antigen CD19 (CD19); T-cell surface glycoprotein CD3 delta chain (CD3D)
Monomethyl auristatin E
Blinatumomab-Compound 69 linker
Brentuximab-Compound 69 [285]
Brentuximab
Tumor necrosis factor receptor superfamily member 8 (TNFRSF8)
Monomethyl auristatin E
Brentuximab-Compound 69 linker
Sacituzumab-Compound 69 [285]
Sacituzumab
Tumor-associated calcium signal transducer 2 (TACSTD2)
Monomethyl auristatin E
Sacituzumab-Compound 69 linker
Panitumumab-Compound 69 [285]
Panitumumab
Epidermal growth factor receptor (EGFR)
Monomethyl auristatin E
Panitumumab-Compound 69 linker
Nimotuzumab-Compound 69 [285]
Nimotuzumab
Epidermal growth factor receptor (EGFR)
Monomethyl auristatin E
Nimotuzumab-Compound 69 linker
Gemtuzumab-Compound 69 [285]
Gemtuzumab
Myeloid cell surface antigen CD33 (CD33)
Monomethyl auristatin E
Gemtuzumab-Compound 69 linker
Golimumab-Compound 69 [285]
Golimumab
Tumor necrosis factor (TNF)
Monomethyl auristatin E
Golimumab-Compound 69 linker
Ibritumomab-Compound 69 [285]
Ibritumomab
B-lymphocyte antigen CD20 (MS4A1)
Monomethyl auristatin E
Ibritumomab-Compound 69 linker
Infliximab-Compound 69 [285]
Infliximab
Tumor necrosis factor (TNF)
Monomethyl auristatin E
Infliximab-Compound 69 linker
Ipilimumab-Compound 69 [285]
Ipilimumab
Cytotoxic T-lymphocyte protein 4 (CTLA4)
Monomethyl auristatin E
Ipilimumab-Compound 69 linker
Ofatumumab-Compound 69 [285]
Ofatumumab
B-lymphocyte antigen CD20 (MS4A1)
Monomethyl auristatin E
Ofatumumab-Compound 69 linker
Tositumomab-Compound 69 [285]
Tositumomab
B-lymphocyte antigen CD20 (MS4A1)
Monomethyl auristatin E
Tositumomab-Compound 69 linker
Trastuzumab-Compound 75 [285]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
Trastuzumab-Compound 75 linker
Pertuzumab-Compound 75 [285]
Pertuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
Pertuzumab-Compound 75 linker
Rituximab-Compound 75 [285]
Rituximab
B-lymphocyte antigen CD20 (MS4A1)
Monomethyl auristatin E
Rituximab-Compound 75 linker
Alemtuzumab-Compound 75 [285]
Alemtuzumab
CAMPATH-1 antigen (CD52)
Monomethyl auristatin E
Alemtuzumab-Compound 75 linker
Bevacizumab-Compound 75 [285]
Bevacizumab
Vascular endothelial growth factor A (VEGFA)
Monomethyl auristatin E
Bevacizumab-Compound 75 linker
Adalimumab-Compound 75 [285]
Adalimumab
Tumor necrosis factor (TNF)
Monomethyl auristatin E
Adalimumab-Compound 75 linker
Cetuximab-Compound 75 [285]
Cetuximab
Epidermal growth factor receptor (EGFR)
Monomethyl auristatin E
Cetuximab-Compound 75 linker
Amatuximab-Compound 75 [285]
Amatuximab
Mesothelin (MSLN)
Monomethyl auristatin E
Amatuximab-Compound 75 linker
Blinatumomab-Compound 75 [285]
Blinatumomab
B-lymphocyte antigen CD19 (CD19); T-cell surface glycoprotein CD3 delta chain (CD3D)
Monomethyl auristatin E
Blinatumomab-Compound 75 linker
Brentuximab-Compound 75 [285]
Brentuximab
Tumor necrosis factor receptor superfamily member 8 (TNFRSF8)
Monomethyl auristatin E
Brentuximab-Compound 75 linker
Sacituzumab-Compound 75 [285]
Sacituzumab
Tumor-associated calcium signal transducer 2 (TACSTD2)
Monomethyl auristatin E
Sacituzumab-Compound 75 linker
Panitumumab-Compound 75 [285]
Panitumumab
Epidermal growth factor receptor (EGFR)
Monomethyl auristatin E
Panitumumab-Compound 75 linker
Nimotuzumab-Compound 75 [285]
Nimotuzumab
Epidermal growth factor receptor (EGFR)
Monomethyl auristatin E
Nimotuzumab-Compound 75 linker
Gemtuzumab-Compound 75 [285]
Gemtuzumab
Myeloid cell surface antigen CD33 (CD33)
Monomethyl auristatin E
Gemtuzumab-Compound 75 linker
Golimumab-Compound 75 [285]
Golimumab
Tumor necrosis factor (TNF)
Monomethyl auristatin E
Golimumab-Compound 75 linker
Ibritumomab-Compound 75 [285]
Ibritumomab
B-lymphocyte antigen CD20 (MS4A1)
Monomethyl auristatin E
Ibritumomab-Compound 75 linker
Infliximab-Compound 75 [285]
Infliximab
Tumor necrosis factor (TNF)
Monomethyl auristatin E
Infliximab-Compound 75 linker
Ipilimumab-Compound 75 [285]
Ipilimumab
Cytotoxic T-lymphocyte protein 4 (CTLA4)
Monomethyl auristatin E
Ipilimumab-Compound 75 linker
Ofatumumab-Compound 75 [285]
Ofatumumab
B-lymphocyte antigen CD20 (MS4A1)
Monomethyl auristatin E
Ofatumumab-Compound 75 linker
Tositumomab-Compound 75 [285]
Tositumomab
B-lymphocyte antigen CD20 (MS4A1)
Monomethyl auristatin E
Tositumomab-Compound 75 linker
Trastuzumab-Compound 76 [285]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
Trastuzumab-Compound 76 linker
Pertuzumab-Compound 76 [285]
Pertuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
Pertuzumab-Compound 76 linker
Rituximab-Compound 76 [285]
Rituximab
B-lymphocyte antigen CD20 (MS4A1)
Monomethyl auristatin E
Rituximab-Compound 76 linker
Alemtuzumab-Compound 76 [285]
Alemtuzumab
CAMPATH-1 antigen (CD52)
Monomethyl auristatin E
Alemtuzumab-Compound 76 linker
Bevacizumab-Compound 76 [285]
Bevacizumab
Vascular endothelial growth factor A (VEGFA)
Monomethyl auristatin E
Bevacizumab-Compound 76 linker
Adalimumab-Compound 76 [285]
Adalimumab
Tumor necrosis factor (TNF)
Monomethyl auristatin E
Adalimumab-Compound 76 linker
Cetuximab-Compound 76 [285]
Cetuximab
Epidermal growth factor receptor (EGFR)
Monomethyl auristatin E
Cetuximab-Compound 76 linker
Amatuximab-Compound 76 [285]
Amatuximab
Mesothelin (MSLN)
Monomethyl auristatin E
Amatuximab-Compound 76 linker
Blinatumomab-Compound 76 [285]
Blinatumomab
B-lymphocyte antigen CD19 (CD19); T-cell surface glycoprotein CD3 delta chain (CD3D)
Monomethyl auristatin E
Blinatumomab-Compound 76 linker
Brentuximab-Compound 76 [285]
Brentuximab
Tumor necrosis factor receptor superfamily member 8 (TNFRSF8)
Monomethyl auristatin E
Brentuximab-Compound 76 linker
Sacituzumab-Compound 76 [285]
Sacituzumab
Tumor-associated calcium signal transducer 2 (TACSTD2)
Monomethyl auristatin E
Sacituzumab-Compound 76 linker
Panitumumab-Compound 76 [285]
Panitumumab
Epidermal growth factor receptor (EGFR)
Monomethyl auristatin E
Panitumumab-Compound 76 linker
Nimotuzumab-Compound 76 [285]
Nimotuzumab
Epidermal growth factor receptor (EGFR)
Monomethyl auristatin E
Nimotuzumab-Compound 76 linker
Gemtuzumab-Compound 76 [285]
Gemtuzumab
Myeloid cell surface antigen CD33 (CD33)
Monomethyl auristatin E
Gemtuzumab-Compound 76 linker
Golimumab-Compound 76 [285]
Golimumab
Tumor necrosis factor (TNF)
Monomethyl auristatin E
Golimumab-Compound 76 linker
Ibritumomab-Compound 76 [285]
Ibritumomab
B-lymphocyte antigen CD20 (MS4A1)
Monomethyl auristatin E
Ibritumomab-Compound 76 linker
Infliximab-Compound 76 [285]
Infliximab
Tumor necrosis factor (TNF)
Monomethyl auristatin E
Infliximab-Compound 76 linker
Ipilimumab-Compound 76 [285]
Ipilimumab
Cytotoxic T-lymphocyte protein 4 (CTLA4)
Monomethyl auristatin E
Ipilimumab-Compound 76 linker
Ofatumumab-Compound 76 [285]
Ofatumumab
B-lymphocyte antigen CD20 (MS4A1)
Monomethyl auristatin E
Ofatumumab-Compound 76 linker
Tositumomab-Compound 76 [285]
Tositumomab
B-lymphocyte antigen CD20 (MS4A1)
Monomethyl auristatin E
Tositumomab-Compound 76 linker
Trastuzumab-Compound 77 [285]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Mertansine DM1
Trastuzumab-Compound 77 linker
Pertuzumab-Compound 77 [285]
Pertuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Mertansine DM1
Pertuzumab-Compound 77 linker
Rituximab-Compound 77 [285]
Rituximab
B-lymphocyte antigen CD20 (MS4A1)
Mertansine DM1
Rituximab-Compound 77 linker
Alemtuzumab-Compound 77 [285]
Alemtuzumab
CAMPATH-1 antigen (CD52)
Mertansine DM1
Alemtuzumab-Compound 77 linker
Bevacizumab-Compound 77 [285]
Bevacizumab
Vascular endothelial growth factor A (VEGFA)
Mertansine DM1
Bevacizumab-Compound 77 linker
Adalimumab-Compound 77 [285]
Adalimumab
Tumor necrosis factor (TNF)
Mertansine DM1
Adalimumab-Compound 77 linker
Cetuximab-Compound 77 [285]
Cetuximab
Epidermal growth factor receptor (EGFR)
Mertansine DM1
Cetuximab-Compound 77 linker
Amatuximab-Compound 77 [285]
Amatuximab
Mesothelin (MSLN)
Mertansine DM1
Amatuximab-Compound 77 linker
Blinatumomab-Compound 77 [285]
Blinatumomab
B-lymphocyte antigen CD19 (CD19); T-cell surface glycoprotein CD3 delta chain (CD3D)
Mertansine DM1
Blinatumomab-Compound 77 linker
Brentuximab-Compound 77 [285]
Brentuximab
Tumor necrosis factor receptor superfamily member 8 (TNFRSF8)
Mertansine DM1
Brentuximab-Compound 77 linker
Sacituzumab-Compound 77 [285]
Sacituzumab
Tumor-associated calcium signal transducer 2 (TACSTD2)
Mertansine DM1
Sacituzumab-Compound 77 linker
Panitumumab-Compound 77 [285]
Panitumumab
Epidermal growth factor receptor (EGFR)
Mertansine DM1
Panitumumab-Compound 77 linker
Nimotuzumab-Compound 77 [285]
Nimotuzumab
Epidermal growth factor receptor (EGFR)
Mertansine DM1
Nimotuzumab-Compound 77 linker
Gemtuzumab-Compound 77 [285]
Gemtuzumab
Myeloid cell surface antigen CD33 (CD33)
Mertansine DM1
Gemtuzumab-Compound 77 linker
Golimumab-Compound 77 [285]
Golimumab
Tumor necrosis factor (TNF)
Mertansine DM1
Golimumab-Compound 77 linker
Ibritumomab-Compound 77 [285]
Ibritumomab
B-lymphocyte antigen CD20 (MS4A1)
Mertansine DM1
Ibritumomab-Compound 77 linker
Infliximab-Compound 77 [285]
Infliximab
Tumor necrosis factor (TNF)
Mertansine DM1
Infliximab-Compound 77 linker
Ipilimumab-Compound 77 [285]
Ipilimumab
Cytotoxic T-lymphocyte protein 4 (CTLA4)
Mertansine DM1
Ipilimumab-Compound 77 linker
Ofatumumab-Compound 77 [285]
Ofatumumab
B-lymphocyte antigen CD20 (MS4A1)
Mertansine DM1
Ofatumumab-Compound 77 linker
Tositumomab-Compound 77 [285]
Tositumomab
B-lymphocyte antigen CD20 (MS4A1)
Mertansine DM1
Tositumomab-Compound 77 linker
Trastuzumab-Compound 78 [285]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Auristatin 0101
Trastuzumab-Compound 78 linker
Pertuzumab-Compound 78 [285]
Pertuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Auristatin 0101
Pertuzumab-Compound 78 linker
Rituximab-Compound 78 [285]
Rituximab
B-lymphocyte antigen CD20 (MS4A1)
Auristatin 0101
Rituximab-Compound 78 linker
Alemtuzumab-Compound 78 [285]
Alemtuzumab
CAMPATH-1 antigen (CD52)
Auristatin 0101
Alemtuzumab-Compound 78 linker
Bevacizumab-Compound 78 [285]
Bevacizumab
Vascular endothelial growth factor A (VEGFA)
Auristatin 0101
Bevacizumab-Compound 78 linker
Adalimumab-Compound 78 [285]
Adalimumab
Tumor necrosis factor (TNF)
Auristatin 0101
Adalimumab-Compound 78 linker
Cetuximab-Compound 78 [285]
Cetuximab
Epidermal growth factor receptor (EGFR)
Auristatin 0101
Cetuximab-Compound 78 linker
Amatuximab-Compound 78 [285]
Amatuximab
Mesothelin (MSLN)
Auristatin 0101
Amatuximab-Compound 78 linker
Blinatumomab-Compound 78 [285]
Blinatumomab
B-lymphocyte antigen CD19 (CD19); T-cell surface glycoprotein CD3 delta chain (CD3D)
Auristatin 0101
Blinatumomab-Compound 78 linker
Brentuximab-Compound 78 [285]
Brentuximab
Tumor necrosis factor receptor superfamily member 8 (TNFRSF8)
Auristatin 0101
Brentuximab-Compound 78 linker
Sacituzumab-Compound 78 [285]
Sacituzumab
Tumor-associated calcium signal transducer 2 (TACSTD2)
Auristatin 0101
Sacituzumab-Compound 78 linker
Panitumumab-Compound 78 [285]
Panitumumab
Epidermal growth factor receptor (EGFR)
Auristatin 0101
Panitumumab-Compound 78 linker
Nimotuzumab-Compound 78 [285]
Nimotuzumab
Epidermal growth factor receptor (EGFR)
Auristatin 0101
Nimotuzumab-Compound 78 linker
Gemtuzumab-Compound 78 [285]
Gemtuzumab
Myeloid cell surface antigen CD33 (CD33)
Auristatin 0101
Gemtuzumab-Compound 78 linker
Golimumab-Compound 78 [285]
Golimumab
Tumor necrosis factor (TNF)
Auristatin 0101
Golimumab-Compound 78 linker
Ibritumomab-Compound 78 [285]
Ibritumomab
B-lymphocyte antigen CD20 (MS4A1)
Auristatin 0101
Ibritumomab-Compound 78 linker
Infliximab-Compound 78 [285]
Infliximab
Tumor necrosis factor (TNF)
Auristatin 0101
Infliximab-Compound 78 linker
Ipilimumab-Compound 78 [285]
Ipilimumab
Cytotoxic T-lymphocyte protein 4 (CTLA4)
Auristatin 0101
Ipilimumab-Compound 78 linker
Ofatumumab-Compound 78 [285]
Ofatumumab
B-lymphocyte antigen CD20 (MS4A1)
Auristatin 0101
Ofatumumab-Compound 78 linker
Tositumomab-Compound 78 [285]
Tositumomab
B-lymphocyte antigen CD20 (MS4A1)
Auristatin 0101
Tositumomab-Compound 78 linker
Trastuzumab-Compound 79 [285]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Auristatin 0101
Trastuzumab-Compound 79 linker
Pertuzumab-Compound 79 [285]
Pertuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Auristatin 0101
Pertuzumab-Compound 79 linker
Rituximab-Compound 79 [285]
Rituximab
B-lymphocyte antigen CD20 (MS4A1)
Auristatin 0101
Rituximab-Compound 79 linker
Alemtuzumab-Compound 79 [285]
Alemtuzumab
CAMPATH-1 antigen (CD52)
Auristatin 0101
Alemtuzumab-Compound 79 linker
Bevacizumab-Compound 79 [285]
Bevacizumab
Vascular endothelial growth factor A (VEGFA)
Auristatin 0101
Bevacizumab-Compound 79 linker
Adalimumab-Compound 79 [285]
Adalimumab
Tumor necrosis factor (TNF)
Auristatin 0101
Adalimumab-Compound 79 linker
Cetuximab-Compound 79 [285]
Cetuximab
Epidermal growth factor receptor (EGFR)
Auristatin 0101
Cetuximab-Compound 79 linker
Amatuximab-Compound 79 [285]
Amatuximab
Mesothelin (MSLN)
Auristatin 0101
Amatuximab-Compound 79 linker
Blinatumomab-Compound 79 [285]
Blinatumomab
B-lymphocyte antigen CD19 (CD19); T-cell surface glycoprotein CD3 delta chain (CD3D)
Auristatin 0101
Blinatumomab-Compound 79 linker
Brentuximab-Compound 79 [285]
Brentuximab
Tumor necrosis factor receptor superfamily member 8 (TNFRSF8)
Auristatin 0101
Brentuximab-Compound 79 linker
Sacituzumab-Compound 79 [285]
Sacituzumab
Tumor-associated calcium signal transducer 2 (TACSTD2)
Auristatin 0101
Sacituzumab-Compound 79 linker
Panitumumab-Compound 79 [285]
Panitumumab
Epidermal growth factor receptor (EGFR)
Auristatin 0101
Panitumumab-Compound 79 linker
Nimotuzumab-Compound 79 [285]
Nimotuzumab
Epidermal growth factor receptor (EGFR)
Auristatin 0101
Nimotuzumab-Compound 79 linker
Gemtuzumab-Compound 79 [285]
Gemtuzumab
Myeloid cell surface antigen CD33 (CD33)
Auristatin 0101
Gemtuzumab-Compound 79 linker
Golimumab-Compound 79 [285]
Golimumab
Tumor necrosis factor (TNF)
Auristatin 0101
Golimumab-Compound 79 linker
Ibritumomab-Compound 79 [285]
Ibritumomab
B-lymphocyte antigen CD20 (MS4A1)
Auristatin 0101
Ibritumomab-Compound 79 linker
Infliximab-Compound 79 [285]
Infliximab
Tumor necrosis factor (TNF)
Auristatin 0101
Infliximab-Compound 79 linker
Ipilimumab-Compound 79 [285]
Ipilimumab
Cytotoxic T-lymphocyte protein 4 (CTLA4)
Auristatin 0101
Ipilimumab-Compound 79 linker
Ofatumumab-Compound 79 [285]
Ofatumumab
B-lymphocyte antigen CD20 (MS4A1)
Auristatin 0101
Ofatumumab-Compound 79 linker
Tositumomab-Compound 79 [285]
Tositumomab
B-lymphocyte antigen CD20 (MS4A1)
Auristatin 0101
Tositumomab-Compound 79 linker
Trastuzumab-Compound 80 [285]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Mertansine DM4
Trastuzumab-Compound 80 linker
Pertuzumab-Compound 80 [285]
Pertuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Mertansine DM4
Pertuzumab-Compound 80 linker
Rituximab-Compound 80 [285]
Rituximab
B-lymphocyte antigen CD20 (MS4A1)
Mertansine DM4
Rituximab-Compound 80 linker
Alemtuzumab-Compound 80 [285]
Alemtuzumab
CAMPATH-1 antigen (CD52)
Mertansine DM4
Alemtuzumab-Compound 80 linker
Bevacizumab-Compound 80 [285]
Bevacizumab
Vascular endothelial growth factor A (VEGFA)
Mertansine DM4
Bevacizumab-Compound 80 linker
Adalimumab-Compound 80 [285]
Adalimumab
Tumor necrosis factor (TNF)
Mertansine DM4
Adalimumab-Compound 80 linker
Cetuximab-Compound 80 [285]
Cetuximab
Epidermal growth factor receptor (EGFR)
Mertansine DM4
Cetuximab-Compound 80 linker
Amatuximab-Compound 80 [285]
Amatuximab
Mesothelin (MSLN)
Mertansine DM4
Amatuximab-Compound 80 linker
Blinatumomab-Compound 80 [285]
Blinatumomab
B-lymphocyte antigen CD19 (CD19); T-cell surface glycoprotein CD3 delta chain (CD3D)
Mertansine DM4
Blinatumomab-Compound 80 linker
Brentuximab-Compound 80 [285]
Brentuximab
Tumor necrosis factor receptor superfamily member 8 (TNFRSF8)
Mertansine DM4
Brentuximab-Compound 80 linker
Sacituzumab-Compound 80 [285]
Sacituzumab
Tumor-associated calcium signal transducer 2 (TACSTD2)
Mertansine DM4
Sacituzumab-Compound 80 linker
Panitumumab-Compound 80 [285]
Panitumumab
Epidermal growth factor receptor (EGFR)
Mertansine DM4
Panitumumab-Compound 80 linker
Nimotuzumab-Compound 80 [285]
Nimotuzumab
Epidermal growth factor receptor (EGFR)
Mertansine DM4
Nimotuzumab-Compound 80 linker
Gemtuzumab-Compound 80 [285]
Gemtuzumab
Myeloid cell surface antigen CD33 (CD33)
Mertansine DM4
Gemtuzumab-Compound 80 linker
Golimumab-Compound 80 [285]
Golimumab
Tumor necrosis factor (TNF)
Mertansine DM4
Golimumab-Compound 80 linker
Ibritumomab-Compound 80 [285]
Ibritumomab
B-lymphocyte antigen CD20 (MS4A1)
Mertansine DM4
Ibritumomab-Compound 80 linker
Infliximab-Compound 80 [285]
Infliximab
Tumor necrosis factor (TNF)
Mertansine DM4
Infliximab-Compound 80 linker
Ipilimumab-Compound 80 [285]
Ipilimumab
Cytotoxic T-lymphocyte protein 4 (CTLA4)
Mertansine DM4
Ipilimumab-Compound 80 linker
Ofatumumab-Compound 80 [285]
Ofatumumab
B-lymphocyte antigen CD20 (MS4A1)
Mertansine DM4
Ofatumumab-Compound 80 linker
Tositumomab-Compound 80 [285]
Tositumomab
B-lymphocyte antigen CD20 (MS4A1)
Mertansine DM4
Tositumomab-Compound 80 linker
Anti-MSL1 mAb-Compound 9 [285]
Anti-MSL1 mAb
Male-specific lethal 1 homolog (MSL1)
Mertansine DM1
Anti-MSL1 mAb-Compound 9 linker
Anti-CD59 mAb-Compound 9 [285]
Anti-CD59 mAb
CD59 glycoprotein (CD59)
Mertansine DM1
Anti-CD59 mAb-Compound 9 linker
Anti-HER2 mAb-Compound 9 [285]
Anti-HER2 mAb
Receptor tyrosine-protein kinase erbB-2 (HER2)
Mertansine DM1
Anti-HER2 mAb-Compound 9 linker
Anti-MSL1 mAb-Compound 17 [285]
Anti-MSL1 mAb
Male-specific lethal 1 homolog (MSL1)
Mertansine DM4
Anti-MSL1 mAb-Compound 17 linker
Anti-CD59 mAb-Compound 17 [285]
Anti-CD59 mAb
CD59 glycoprotein (CD59)
Mertansine DM4
Anti-CD59 mAb-Compound 17 linker
Anti-HER2 mAb-Compound 17 [285]
Anti-HER2 mAb
Receptor tyrosine-protein kinase erbB-2 (HER2)
Mertansine DM4
Anti-HER2 mAb-Compound 17 linker
Anti-MSL1 mAb-Compound 25 [285]
Anti-MSL1 mAb
Male-specific lethal 1 homolog (MSL1)
Monomethyl auristatin E
Anti-MSL1 mAb-Compound 25 linker
Anti-CD59 mAb-Compound 25 [285]
Anti-CD59 mAb
CD59 glycoprotein (CD59)
Monomethyl auristatin E
Anti-CD59 mAb-Compound 25 linker
Anti-HER2 mAb-Compound 25 [285]
Anti-HER2 mAb
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
Anti-HER2 mAb-Compound 25 linker
Anti-MSL1 mAb-Compound 31 [285]
Anti-MSL1 mAb
Male-specific lethal 1 homolog (MSL1)
Auristatin 0101
Anti-MSL1 mAb-Compound 31 linker
Anti-CD59 mAb-Compound 31 [285]
Anti-CD59 mAb
CD59 glycoprotein (CD59)
Auristatin 0101
Anti-CD59 mAb-Compound 31 linker
Anti-HER2 mAb-Compound 31 [285]
Anti-HER2 mAb
Receptor tyrosine-protein kinase erbB-2 (HER2)
Auristatin 0101
Anti-HER2 mAb-Compound 31 linker
Anti-MSL1 mAb-Compound 36 [285]
Anti-MSL1 mAb
Male-specific lethal 1 homolog (MSL1)
Monomethyl auristatin E
Anti-MSL1 mAb-Compound 36 linker
Anti-CD59 mAb-Compound 36 [285]
Anti-CD59 mAb
CD59 glycoprotein (CD59)
Monomethyl auristatin E
Anti-CD59 mAb-Compound 36 linker
Anti-HER2 mAb-Compound 36 [285]
Anti-HER2 mAb
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
Anti-HER2 mAb-Compound 36 linker
Anti-MSL1 mAb-Compound 55 [285]
Anti-MSL1 mAb
Male-specific lethal 1 homolog (MSL1)
Mertansine DM1
Anti-MSL1 mAb-Compound 55 linker
Anti-CD59 mAb-Compound 55 [285]
Anti-CD59 mAb
CD59 glycoprotein (CD59)
Mertansine DM1
Anti-CD59 mAb-Compound 55 linker
Anti-HER2 mAb-Compound 55 [285]
Anti-HER2 mAb
Receptor tyrosine-protein kinase erbB-2 (HER2)
Mertansine DM1
Anti-HER2 mAb-Compound 55 linker
Anti-MSL1 mAb-Compound 59 [285]
Anti-MSL1 mAb
Male-specific lethal 1 homolog (MSL1)
Mertansine DM4
Anti-MSL1 mAb-Compound 59 linker
Anti-CD59 mAb-Compound 59 [285]
Anti-CD59 mAb
CD59 glycoprotein (CD59)
Mertansine DM4
Anti-CD59 mAb-Compound 59 linker
Anti-HER2 mAb-Compound 59 [285]
Anti-HER2 mAb
Receptor tyrosine-protein kinase erbB-2 (HER2)
Mertansine DM4
Anti-HER2 mAb-Compound 59 linker
Anti-MSL1 mAb-Compound 64 [285]
Anti-MSL1 mAb
Male-specific lethal 1 homolog (MSL1)
Monomethyl auristatin E
Anti-MSL1 mAb-Compound 64 linker
Anti-CD59 mAb-Compound 64 [285]
Anti-CD59 mAb
CD59 glycoprotein (CD59)
Monomethyl auristatin E
Anti-CD59 mAb-Compound 64 linker
Anti-HER2 mAb-Compound 64 [285]
Anti-HER2 mAb
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
Anti-HER2 mAb-Compound 64 linker
Anti-MSL1 mAb-Compound 69 [285]
Anti-MSL1 mAb
Male-specific lethal 1 homolog (MSL1)
Monomethyl auristatin E
Anti-MSL1 mAb-Compound 69 linker
Anti-CD59 mAb-Compound 69 [285]
Anti-CD59 mAb
CD59 glycoprotein (CD59)
Monomethyl auristatin E
Anti-CD59 mAb-Compound 69 linker
Anti-HER2 mAb-Compound 69 [285]
Anti-HER2 mAb
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
Anti-HER2 mAb-Compound 69 linker
Anti-MSL1 mAb-Compound 75 [285]
Anti-MSL1 mAb
Male-specific lethal 1 homolog (MSL1)
Monomethyl auristatin E
Anti-MSL1 mAb-Compound 75 linker
Anti-CD59 mAb-Compound 75 [285]
Anti-CD59 mAb
CD59 glycoprotein (CD59)
Monomethyl auristatin E
Anti-CD59 mAb-Compound 75 linker
Anti-HER2 mAb-Compound 75 [285]
Anti-HER2 mAb
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
Anti-HER2 mAb-Compound 75 linker
Anti-MSL1 mAb-Compound 76 [285]
Anti-MSL1 mAb
Male-specific lethal 1 homolog (MSL1)
Monomethyl auristatin E
Anti-MSL1 mAb-Compound 76 linker
Anti-CD59 mAb-Compound 76 [285]
Anti-CD59 mAb
CD59 glycoprotein (CD59)
Monomethyl auristatin E
Anti-CD59 mAb-Compound 76 linker
Anti-HER2 mAb-Compound 76 [285]
Anti-HER2 mAb
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
Anti-HER2 mAb-Compound 76 linker
Anti-MSL1 mAb-Compound 77 [285]
Anti-MSL1 mAb
Male-specific lethal 1 homolog (MSL1)
Mertansine DM1
Anti-MSL1 mAb-Compound 77 linker
Anti-CD59 mAb-Compound 77 [285]
Anti-CD59 mAb
CD59 glycoprotein (CD59)
Mertansine DM1
Anti-CD59 mAb-Compound 77 linker
Anti-HER2 mAb-Compound 77 [285]
Anti-HER2 mAb
Receptor tyrosine-protein kinase erbB-2 (HER2)
Mertansine DM1
Anti-HER2 mAb-Compound 77 linker
Anti-MSL1 mAb-Compound 78 [285]
Anti-MSL1 mAb
Male-specific lethal 1 homolog (MSL1)
Auristatin 0101
Anti-MSL1 mAb-Compound 78 linker
Anti-CD59 mAb-Compound 78 [285]
Anti-CD59 mAb
CD59 glycoprotein (CD59)
Auristatin 0101
Anti-CD59 mAb-Compound 78 linker
Anti-HER2 mAb-Compound 78 [285]
Anti-HER2 mAb
Receptor tyrosine-protein kinase erbB-2 (HER2)
Auristatin 0101
Anti-HER2 mAb-Compound 78 linker
Anti-MSL1 mAb-Compound 79 [285]
Anti-MSL1 mAb
Male-specific lethal 1 homolog (MSL1)
Auristatin 0101
Anti-MSL1 mAb-Compound 79 linker
Anti-CD59 mAb-Compound 79 [285]
Anti-CD59 mAb
CD59 glycoprotein (CD59)
Auristatin 0101
Anti-CD59 mAb-Compound 79 linker
Anti-HER2 mAb-Compound 79 [285]
Anti-HER2 mAb
Receptor tyrosine-protein kinase erbB-2 (HER2)
Auristatin 0101
Anti-HER2 mAb-Compound 79 linker
Anti-MSL1 mAb-Compound 80 [285]
Anti-MSL1 mAb
Male-specific lethal 1 homolog (MSL1)
Mertansine DM4
Anti-MSL1 mAb-Compound 80 linker
Anti-CD59 mAb-Compound 80 [285]
Anti-CD59 mAb
CD59 glycoprotein (CD59)
Mertansine DM4
Anti-CD59 mAb-Compound 80 linker
Anti-HER2 mAb-Compound 80 [285]
Anti-HER2 mAb
Receptor tyrosine-protein kinase erbB-2 (HER2)
Mertansine DM4
Anti-HER2 mAb-Compound 80 linker
H-1-vcMMAE [286]
Anti-HER2 mAb H-1
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
Mc-Val-Cit-PABC
H-3-vcMMAE [286]
Anti-HER2 mAb H-3
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
Mc-Val-Cit-PABC
H-4-vcMMAE [286]
Anti-HER2 mAb H-4
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
Mc-Val-Cit-PABC
Anti-KIT 9P3-SMCC-DM1 [287]
Anti-KIT mAb 9P3
Mast/stem cell growth factor receptor Kit (KIT)
Mertansine DM1
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
Anti-KIT NEG024-SMCC-DM1 [287]
Anti-KIT mAb NEG024
Mast/stem cell growth factor receptor Kit (KIT)
Mertansine DM1
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
Anti-KIT NEG026-SMCC-DM1 [287]
Anti-KIT mAb NEG026
Mast/stem cell growth factor receptor Kit (KIT)
Mertansine DM1
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
Anti-KIT NEG027-SMCC-DM1 [287]
Anti-KIT mAb NEG027
Mast/stem cell growth factor receptor Kit (KIT)
Mertansine DM1
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
Anti-KIT NEG085-SMCC-DM1 [287]
Anti-KIT mAb NEG085
Mast/stem cell growth factor receptor Kit (KIT)
Mertansine DM1
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
Anti-KIT NEG086-SMCC-DM1 [287]
Anti-KIT mAb NEG086
Mast/stem cell growth factor receptor Kit (KIT)
Mertansine DM1
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
Anti-KIT NEG087-SMCC-DM1 [287]
Anti-KIT mAb NEG087
Mast/stem cell growth factor receptor Kit (KIT)
Mertansine DM1
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
Anti-KIT 20376-SMCC-DM1 [287]
Anti-KIT mAb 20376
Mast/stem cell growth factor receptor Kit (KIT)
Mertansine DM1
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
Anti-KIT 9P3-SPDB-DM4 [287]
Anti-KIT mAb 9P3
Mast/stem cell growth factor receptor Kit (KIT)
Mertansine DM4
N-succinimidyl 4-(2-pyridyldithio) butanoate (SPDB)
Anti-KIT NEG024-SPDB-DM4 [287]
Anti-KIT mAb NEG024
Mast/stem cell growth factor receptor Kit (KIT)
Mertansine DM4
N-succinimidyl 4-(2-pyridyldithio) butanoate (SPDB)
Anti-KIT NEG026-SPDB-DM4 [287]
Anti-KIT mAb NEG026
Mast/stem cell growth factor receptor Kit (KIT)
Mertansine DM4
N-succinimidyl 4-(2-pyridyldithio) butanoate (SPDB)
Anti-KIT NEG027-SPDB-DM4 [287]
Anti-KIT mAb NEG027
Mast/stem cell growth factor receptor Kit (KIT)
Mertansine DM4
N-succinimidyl 4-(2-pyridyldithio) butanoate (SPDB)
Anti-KIT NEG085-SPDB-DM4 [287]
Anti-KIT mAb NEG085
Mast/stem cell growth factor receptor Kit (KIT)
Mertansine DM4
N-succinimidyl 4-(2-pyridyldithio) butanoate (SPDB)
Anti-KIT NEG086-SPDB-DM4 [287]
Anti-KIT mAb NEG086
Mast/stem cell growth factor receptor Kit (KIT)
Mertansine DM4
N-succinimidyl 4-(2-pyridyldithio) butanoate (SPDB)
Anti-KIT NEG087-SPDB-DM4 [287]
Anti-KIT mAb NEG087
Mast/stem cell growth factor receptor Kit (KIT)
Mertansine DM4
N-succinimidyl 4-(2-pyridyldithio) butanoate (SPDB)
Anti-KIT 20376-SPDB-DM4 [287]
Anti-KIT mAb 20376
Mast/stem cell growth factor receptor Kit (KIT)
Mertansine DM4
N-succinimidyl 4-(2-pyridyldithio) butanoate (SPDB)
Anti-KIT 9P3-CX1-1-DM1 [287]
Anti-KIT mAb 9P3
Mast/stem cell growth factor receptor Kit (KIT)
Mertansine DM1
2,5-Dioxopyrrolidin-1-yl 17-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)-5,8,11,14-tetraazaheptadecan-1-oate (CX1-1)
Anti-KIT NEG024-CX1-1-DM1 [287]
Anti-KIT mAb NEG024
Mast/stem cell growth factor receptor Kit (KIT)
Mertansine DM1
2,5-Dioxopyrrolidin-1-yl 17-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)-5,8,11,14-tetraazaheptadecan-1-oate (CX1-1)
Anti-KIT NEG026-CX1-1-DM1 [287]
Anti-KIT mAb NEG026
Mast/stem cell growth factor receptor Kit (KIT)
Mertansine DM1
2,5-Dioxopyrrolidin-1-yl 17-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)-5,8,11,14-tetraazaheptadecan-1-oate (CX1-1)
Anti-KIT NEG027-CX1-1-DM1 [287]
Anti-KIT mAb NEG027
Mast/stem cell growth factor receptor Kit (KIT)
Mertansine DM1
2,5-Dioxopyrrolidin-1-yl 17-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)-5,8,11,14-tetraazaheptadecan-1-oate (CX1-1)
Anti-KIT NEG085-CX1-1-DM1 [287]
Anti-KIT mAb NEG085
Mast/stem cell growth factor receptor Kit (KIT)
Mertansine DM1
2,5-Dioxopyrrolidin-1-yl 17-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)-5,8,11,14-tetraazaheptadecan-1-oate (CX1-1)
Anti-KIT NEG086-CX1-1-DM1 [287]
Anti-KIT mAb NEG086
Mast/stem cell growth factor receptor Kit (KIT)
Mertansine DM1
2,5-Dioxopyrrolidin-1-yl 17-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)-5,8,11,14-tetraazaheptadecan-1-oate (CX1-1)
Anti-KIT NEG087-CX1-1-DM1 [287]
Anti-KIT mAb NEG087
Mast/stem cell growth factor receptor Kit (KIT)
Mertansine DM1
2,5-Dioxopyrrolidin-1-yl 17-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)-5,8,11,14-tetraazaheptadecan-1-oate (CX1-1)
Anti-KIT 20376-CX1-1-DM1 [287]
Anti-KIT mAb 20376
Mast/stem cell growth factor receptor Kit (KIT)
Mertansine DM1
2,5-Dioxopyrrolidin-1-yl 17-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)-5,8,11,14-tetraazaheptadecan-1-oate (CX1-1)
Anti-KIT 9P3-SSNPP-DM3 [287]
Anti-KIT mAb 9P3
Mast/stem cell growth factor receptor Kit (KIT)
Maytansinoid DM3
Sulfosuccinimidyl-N-succinimidyl-4-(5-nitro-2-pyridyldithio) pentanoate (SSNPP)
Anti-KIT NEG024-SSNPP-DM3 [287]
Anti-KIT mAb NEG024
Mast/stem cell growth factor receptor Kit (KIT)
Maytansinoid DM3
Sulfosuccinimidyl-N-succinimidyl-4-(5-nitro-2-pyridyldithio) pentanoate (SSNPP)
Anti-KIT NEG026-SSNPP-DM3 [287]
Anti-KIT mAb NEG026
Mast/stem cell growth factor receptor Kit (KIT)
Maytansinoid DM3
Sulfosuccinimidyl-N-succinimidyl-4-(5-nitro-2-pyridyldithio) pentanoate (SSNPP)
Anti-KIT NEG027-SSNPP-DM3 [287]
Anti-KIT mAb NEG027
Mast/stem cell growth factor receptor Kit (KIT)
Maytansinoid DM3
Sulfosuccinimidyl-N-succinimidyl-4-(5-nitro-2-pyridyldithio) pentanoate (SSNPP)
Anti-KIT NEG085-SSNPP-DM3 [287]
Anti-KIT mAb NEG085
Mast/stem cell growth factor receptor Kit (KIT)
Maytansinoid DM3
Sulfosuccinimidyl-N-succinimidyl-4-(5-nitro-2-pyridyldithio) pentanoate (SSNPP)
Anti-KIT NEG086-SSNPP-DM3 [287]
Anti-KIT mAb NEG086
Mast/stem cell growth factor receptor Kit (KIT)
Maytansinoid DM3
Sulfosuccinimidyl-N-succinimidyl-4-(5-nitro-2-pyridyldithio) pentanoate (SSNPP)
Anti-KIT NEG087-SSNPP-DM3 [287]
Anti-KIT mAb NEG087
Mast/stem cell growth factor receptor Kit (KIT)
Maytansinoid DM3
Sulfosuccinimidyl-N-succinimidyl-4-(5-nitro-2-pyridyldithio) pentanoate (SSNPP)
Anti-KIT 20376-SSNPP-DM3 [287]
Anti-KIT mAb 20376
Mast/stem cell growth factor receptor Kit (KIT)
Maytansinoid DM3
Sulfosuccinimidyl-N-succinimidyl-4-(5-nitro-2-pyridyldithio) pentanoate (SSNPP)
Anti-KIT 9P3-SPP-DM1 [287]
Anti-KIT mAb 9P3
Mast/stem cell growth factor receptor Kit (KIT)
Mertansine DM1
N-succinimidyl 4-(2-pyridyldithio) pentanoate (SPP)
Anti-KIT NEG024-SPP-DM1 [287]
Anti-KIT mAb NEG024
Mast/stem cell growth factor receptor Kit (KIT)
Mertansine DM1
N-succinimidyl 4-(2-pyridyldithio) pentanoate (SPP)
Anti-KIT NEG026-SPP-DM1 [287]
Anti-KIT mAb NEG026
Mast/stem cell growth factor receptor Kit (KIT)
Mertansine DM1
N-succinimidyl 4-(2-pyridyldithio) pentanoate (SPP)
Anti-KIT NEG027-SPP-DM1 [287]
Anti-KIT mAb NEG027
Mast/stem cell growth factor receptor Kit (KIT)
Mertansine DM1
N-succinimidyl 4-(2-pyridyldithio) pentanoate (SPP)
Anti-KIT NEG085-SPP-DM1 [287]
Anti-KIT mAb NEG085
Mast/stem cell growth factor receptor Kit (KIT)
Mertansine DM1
N-succinimidyl 4-(2-pyridyldithio) pentanoate (SPP)
Anti-KIT NEG086-SPP-DM1 [287]
Anti-KIT mAb NEG086
Mast/stem cell growth factor receptor Kit (KIT)
Mertansine DM1
N-succinimidyl 4-(2-pyridyldithio) pentanoate (SPP)
Anti-KIT NEG087-SPP-DM1 [287]
Anti-KIT mAb NEG087
Mast/stem cell growth factor receptor Kit (KIT)
Mertansine DM1
N-succinimidyl 4-(2-pyridyldithio) pentanoate (SPP)
Anti-KIT 20376-SPP-DM1 [287]
Anti-KIT mAb 20376
Mast/stem cell growth factor receptor Kit (KIT)
Mertansine DM1
N-succinimidyl 4-(2-pyridyldithio) pentanoate (SPP)
Anti-KIT 9P3-SPDP-DM1 [287]
Anti-KIT mAb 9P3
Mast/stem cell growth factor receptor Kit (KIT)
Mertansine DM1
N-succinimidyl 3-(2-pyridyldithio) propionate (SPDP)
Anti-KIT NEG024-SPDP-DM1 [287]
Anti-KIT mAb NEG024
Mast/stem cell growth factor receptor Kit (KIT)
Mertansine DM1
N-succinimidyl 3-(2-pyridyldithio) propionate (SPDP)
Anti-KIT NEG026-SPDP-DM1 [287]
Anti-KIT mAb NEG026
Mast/stem cell growth factor receptor Kit (KIT)
Mertansine DM1
N-succinimidyl 3-(2-pyridyldithio) propionate (SPDP)
Anti-KIT NEG027-SPDP-DM1 [287]
Anti-KIT mAb NEG027
Mast/stem cell growth factor receptor Kit (KIT)
Mertansine DM1
N-succinimidyl 3-(2-pyridyldithio) propionate (SPDP)
Anti-KIT NEG085-SPDP-DM1 [287]
Anti-KIT mAb NEG085
Mast/stem cell growth factor receptor Kit (KIT)
Mertansine DM1
N-succinimidyl 3-(2-pyridyldithio) propionate (SPDP)
Anti-KIT NEG086-SPDP-DM1 [287]
Anti-KIT mAb NEG086
Mast/stem cell growth factor receptor Kit (KIT)
Mertansine DM1
N-succinimidyl 3-(2-pyridyldithio) propionate (SPDP)
Anti-KIT NEG087-SPDP-DM1 [287]
Anti-KIT mAb NEG087
Mast/stem cell growth factor receptor Kit (KIT)
Mertansine DM1
N-succinimidyl 3-(2-pyridyldithio) propionate (SPDP)
Anti-KIT 20376-SPDP-DM1 [287]
Anti-KIT mAb 20376
Mast/stem cell growth factor receptor Kit (KIT)
Mertansine DM1
N-succinimidyl 3-(2-pyridyldithio) propionate (SPDP)
Anti-KIT 9P3 Sulfo-SPDB-DM4 [287]
Anti-KIT mAb 9P3
Mast/stem cell growth factor receptor Kit (KIT)
Mertansine DM4
Sulfo-SPDB
Anti-KIT NEG024 Sulfo-SPDB-DM4 [287]
Anti-KIT mAb NEG024
Mast/stem cell growth factor receptor Kit (KIT)
Mertansine DM4
Sulfo-SPDB
Anti-KIT NEG026 Sulfo-SPDB-DM4 [287]
Anti-KIT mAb NEG026
Mast/stem cell growth factor receptor Kit (KIT)
Mertansine DM4
Sulfo-SPDB
Anti-KIT NEG027 Sulfo-SPDB-DM4 [287]
Anti-KIT mAb NEG027
Mast/stem cell growth factor receptor Kit (KIT)
Mertansine DM4
Sulfo-SPDB
Anti-KIT NEG085 Sulfo-SPDB-DM4 [287]
Anti-KIT mAb NEG085
Mast/stem cell growth factor receptor Kit (KIT)
Mertansine DM4
Sulfo-SPDB
Anti-KIT NEG086 Sulfo-SPDB-DM4 [287]
Anti-KIT mAb NEG086
Mast/stem cell growth factor receptor Kit (KIT)
Mertansine DM4
Sulfo-SPDB
Anti-KIT NEG087 Sulfo-SPDB-DM4 [287]
Anti-KIT mAb NEG087
Mast/stem cell growth factor receptor Kit (KIT)
Mertansine DM4
Sulfo-SPDB
Anti-KIT 20376 Sulfo-SPDB-DM4 [287]
Anti-KIT mAb 20376
Mast/stem cell growth factor receptor Kit (KIT)
Mertansine DM4
Sulfo-SPDB
Anti-FGFR2/4 mAb-12425 SMCC-DM1 [288]
Anti-FGFR2/4 mAb 12425
Fibroblast growth factor receptor 2 (FGFR2); Fibroblast growth factor receptor 4 (FGFR4)
Mertansine DM1
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
Anti-FGFR2/4 mAb-14629 SMCC-DM1 [288]
Anti-FGFR2/4 mAb 14629
Fibroblast growth factor receptor 2 (FGFR2); Fibroblast growth factor receptor 4 (FGFR4)
Mertansine DM1
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
Anti-FGFR2/4 mAb-20562 SMCC-DM1 [288]
Anti-FGFR2/4 mAb 20562
Fibroblast growth factor receptor 2 (FGFR2); Fibroblast growth factor receptor 4 (FGFR4)
Mertansine DM1
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
Anti-FGFR2/4 mAb-20811 SMCC-DM1 [288]
Anti-FGFR2/4 mAb 20811
Fibroblast growth factor receptor 2 (FGFR2); Fibroblast growth factor receptor 4 (FGFR4)
Mertansine DM1
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
Anti-FGFR2/4 mAb-12422 SMCC-DM1 [288]
Anti-FGFR2/4 mAb 12422
Fibroblast growth factor receptor 2 (FGFR2); Fibroblast growth factor receptor 4 (FGFR4)
Mertansine DM1
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
Anti-FGFR2/4 mAb-12439 SMCC-DM1 [288]
Anti-FGFR2/4 mAb 12439
Fibroblast growth factor receptor 2 (FGFR2); Fibroblast growth factor receptor 4 (FGFR4)
Mertansine DM1
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
Anti-FGFR2 mAb-10164 SMCC-DM1 [288]
Anti-FGFR2 mAb 10164
Fibroblast growth factor receptor 2 (FGFR2)
Mertansine DM1
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
Anti-FGFR2 mAb-10220 SMCC-DM1 [288]
Anti-FGFR2 mAb 10220
Fibroblast growth factor receptor 2 (FGFR2)
Mertansine DM1
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
Anti-FGFR2 mAb-10846 SMCC-DM1 [288]
Anti-FGFR2 mAb 10846
Fibroblast growth factor receptor 2 (FGFR2)
Mertansine DM1
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
Anti-FGFR2/4 mAb-10918 SMCC-DM1 [288]
Anti-FGFR2/4 mAb 10918
Fibroblast growth factor receptor 2 (FGFR2); Fibroblast growth factor receptor 4 (FGFR4)
Mertansine DM1
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
Anti-FGFR2/4 mAb-10923 SMCC-DM1 [288]
Anti-FGFR2/4 mAb 10923
Fibroblast growth factor receptor 2 (FGFR2); Fibroblast growth factor receptor 4 (FGFR4)
Mertansine DM1
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
Anti-FGFR2/4 mAb-11722 SMCC-DM1 [288]
Anti-FGFR2/4 mAb 11722
Fibroblast growth factor receptor 2 (FGFR2); Fibroblast growth factor receptor 4 (FGFR4)
Mertansine DM1
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
Anti-FGFR2 mAb-11723 SMCC-DM1 [288]
Anti-FGFR2 mAb 11723
Fibroblast growth factor receptor 2 (FGFR2)
Mertansine DM1
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
Anti-FGFR2 mAb-11725 SMCC-DM1 [288]
Anti-FGFR2 mAb 11725
Fibroblast growth factor receptor 2 (FGFR2)
Mertansine DM1
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
Anti-FGFR2 mAb-12433 SMCC-DM1 [288]
Anti-FGFR2 mAb 12433
Fibroblast growth factor receptor 2 (FGFR2)
Mertansine DM1
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
Anti-FGFR2 mAb-12931 SMCC-DM1 [288]
Anti-FGFR2 mAb 12931
Fibroblast growth factor receptor 2 (FGFR2)
Mertansine DM1
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
Anti-FGFR2 mAb-12944 SMCC-DM1 [288]
Anti-FGFR2 mAb 12944
Fibroblast growth factor receptor 2 (FGFR2)
Mertansine DM1
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
Anti-FGFR2 mAb-12947 SMCC-DM1 [288]
Anti-FGFR2 mAb 12947
Fibroblast growth factor receptor 2 (FGFR2)
Mertansine DM1
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
Anti-FGFR2/4 mAb-10553 SMCC-DM1 [288]
Anti-FGFR2/4 mAb 10553
Fibroblast growth factor receptor 2 (FGFR2); Fibroblast growth factor receptor 4 (FGFR4)
Mertansine DM1
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
Anti-FGFR2/4 mAb-10554 SMCC-DM1 [288]
Anti-FGFR2/4 mAb 10554
Fibroblast growth factor receptor 2 (FGFR2); Fibroblast growth factor receptor 4 (FGFR4)
Mertansine DM1
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
Anti-FGFR2/4 mAb-10925 SMCC-DM1 [288]
Anti-FGFR2/4 mAb 10925
Fibroblast growth factor receptor 2 (FGFR2); Fibroblast growth factor receptor 4 (FGFR4)
Mertansine DM1
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
Anti-FGFR2/4 mAb-10729 SMCC-DM1 [288]
Anti-FGFR2/4 mAb 10729
Fibroblast growth factor receptor 2 (FGFR2); Fibroblast growth factor receptor 4 (FGFR4)
Mertansine DM1
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
Anti-FGFR2/4 mAb-12435 SMCC-DM1 [288]
Anti-FGFR2/4 mAb 12435
Fibroblast growth factor receptor 2 (FGFR2); Fibroblast growth factor receptor 4 (FGFR4)
Mertansine DM1
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
Anti-FGFR2/4 mAb-12438 SMCC-DM1 [288]
Anti-FGFR2/4 mAb 12438
Fibroblast growth factor receptor 2 (FGFR2); Fibroblast growth factor receptor 4 (FGFR4)
Mertansine DM1
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
Anti-FGFR2/4 mAb-12425 SPDB-DM4 [288]
Anti-FGFR2/4 mAb 12425
Fibroblast growth factor receptor 2 (FGFR2); Fibroblast growth factor receptor 4 (FGFR4)
Mertansine DM4
N-succinimidyl 4-(2-pyridyldithio) butanoate (SPDB)
Anti-FGFR2/4 mAb-14629 SPDB-DM4 [288]
Anti-FGFR2/4 mAb 14629
Fibroblast growth factor receptor 2 (FGFR2); Fibroblast growth factor receptor 4 (FGFR4)
Mertansine DM4
N-succinimidyl 4-(2-pyridyldithio) butanoate (SPDB)
Anti-FGFR2/4 mAb-20562 SPDB-DM4 [288]
Anti-FGFR2/4 mAb 20562
Fibroblast growth factor receptor 2 (FGFR2); Fibroblast growth factor receptor 4 (FGFR4)
Mertansine DM4
N-succinimidyl 4-(2-pyridyldithio) butanoate (SPDB)
Anti-FGFR2/4 mAb-20811 SPDB-DM4 [288]
Anti-FGFR2/4 mAb 20811
Fibroblast growth factor receptor 2 (FGFR2); Fibroblast growth factor receptor 4 (FGFR4)
Mertansine DM4
N-succinimidyl 4-(2-pyridyldithio) butanoate (SPDB)
Anti-FGFR2/4 mAb-12422 SPDB-DM4 [288]
Anti-FGFR2/4 mAb 12422
Fibroblast growth factor receptor 2 (FGFR2); Fibroblast growth factor receptor 4 (FGFR4)
Mertansine DM4
N-succinimidyl 4-(2-pyridyldithio) butanoate (SPDB)
Anti-FGFR2/4 mAb-12439 SPDB-DM4 [288]
Anti-FGFR2/4 mAb 12439
Fibroblast growth factor receptor 2 (FGFR2); Fibroblast growth factor receptor 4 (FGFR4)
Mertansine DM4
N-succinimidyl 4-(2-pyridyldithio) butanoate (SPDB)
Anti-FGFR2 mAb-10164 SPDB-DM4 [288]
Anti-FGFR2 mAb 10164
Fibroblast growth factor receptor 2 (FGFR2)
Mertansine DM4
N-succinimidyl 4-(2-pyridyldithio) butanoate (SPDB)
Anti-FGFR2 mAb-10220 SPDB-DM4 [288]
Anti-FGFR2 mAb 10220
Fibroblast growth factor receptor 2 (FGFR2)
Mertansine DM4
N-succinimidyl 4-(2-pyridyldithio) butanoate (SPDB)
Anti-FGFR2 mAb-10846 SPDB-DM4 [288]
Anti-FGFR2 mAb 10846
Fibroblast growth factor receptor 2 (FGFR2)
Mertansine DM4
N-succinimidyl 4-(2-pyridyldithio) butanoate (SPDB)
Anti-FGFR2/4 mAb-10918 SPDB-DM4 [288]
Anti-FGFR2/4 mAb 10918
Fibroblast growth factor receptor 2 (FGFR2); Fibroblast growth factor receptor 4 (FGFR4)
Mertansine DM4
N-succinimidyl 4-(2-pyridyldithio) butanoate (SPDB)
Anti-FGFR2/4 mAb-10923 SPDB-DM4 [288]
Anti-FGFR2/4 mAb 10923
Fibroblast growth factor receptor 2 (FGFR2); Fibroblast growth factor receptor 4 (FGFR4)
Mertansine DM4
N-succinimidyl 4-(2-pyridyldithio) butanoate (SPDB)
Anti-FGFR2/4 mAb-11722 SPDB-DM4 [288]
Anti-FGFR2/4 mAb 11722
Fibroblast growth factor receptor 2 (FGFR2); Fibroblast growth factor receptor 4 (FGFR4)
Mertansine DM4
N-succinimidyl 4-(2-pyridyldithio) butanoate (SPDB)
Anti-FGFR2 mAb-11723 SPDB-DM4 [288]
Anti-FGFR2 mAb 11723
Fibroblast growth factor receptor 2 (FGFR2)
Mertansine DM4
N-succinimidyl 4-(2-pyridyldithio) butanoate (SPDB)
Anti-FGFR2 mAb-11725 SPDB-DM4 [288]
Anti-FGFR2 mAb 11725
Fibroblast growth factor receptor 2 (FGFR2)
Mertansine DM4
N-succinimidyl 4-(2-pyridyldithio) butanoate (SPDB)
Anti-FGFR2 mAb-12433 SPDB-DM4 [288]
Anti-FGFR2 mAb 12433
Fibroblast growth factor receptor 2 (FGFR2)
Mertansine DM4
N-succinimidyl 4-(2-pyridyldithio) butanoate (SPDB)
Anti-FGFR2 mAb-12931 SPDB-DM4 [288]
Anti-FGFR2 mAb 12931
Fibroblast growth factor receptor 2 (FGFR2)
Mertansine DM4
N-succinimidyl 4-(2-pyridyldithio) butanoate (SPDB)
Anti-FGFR2 mAb-12944 SPDB-DM4 [288]
Anti-FGFR2 mAb 12944
Fibroblast growth factor receptor 2 (FGFR2)
Mertansine DM4
N-succinimidyl 4-(2-pyridyldithio) butanoate (SPDB)
Anti-FGFR2 mAb-12947 SPDB-DM4 [288]
Anti-FGFR2 mAb 12947
Fibroblast growth factor receptor 2 (FGFR2)
Mertansine DM4
N-succinimidyl 4-(2-pyridyldithio) butanoate (SPDB)
Anti-FGFR2/4 mAb-10553 SPDB-DM4 [288]
Anti-FGFR2/4 mAb 10553
Fibroblast growth factor receptor 2 (FGFR2); Fibroblast growth factor receptor 4 (FGFR4)
Mertansine DM4
N-succinimidyl 4-(2-pyridyldithio) butanoate (SPDB)
Anti-FGFR2/4 mAb-10554 SPDB-DM4 [288]
Anti-FGFR2/4 mAb 10554
Fibroblast growth factor receptor 2 (FGFR2); Fibroblast growth factor receptor 4 (FGFR4)
Mertansine DM4
N-succinimidyl 4-(2-pyridyldithio) butanoate (SPDB)
Anti-FGFR2/4 mAb-10925 SPDB-DM4 [288]
Anti-FGFR2/4 mAb 10925
Fibroblast growth factor receptor 2 (FGFR2); Fibroblast growth factor receptor 4 (FGFR4)
Mertansine DM4
N-succinimidyl 4-(2-pyridyldithio) butanoate (SPDB)
Anti-FGFR2/4 mAb-10729 SPDB-DM4 [288]
Anti-FGFR2/4 mAb 10729
Fibroblast growth factor receptor 2 (FGFR2); Fibroblast growth factor receptor 4 (FGFR4)
Mertansine DM4
N-succinimidyl 4-(2-pyridyldithio) butanoate (SPDB)
Anti-FGFR2/4 mAb-12435 SPDB-DM4 [288]
Anti-FGFR2/4 mAb 12435
Fibroblast growth factor receptor 2 (FGFR2); Fibroblast growth factor receptor 4 (FGFR4)
Mertansine DM4
N-succinimidyl 4-(2-pyridyldithio) butanoate (SPDB)
Anti-FGFR2/4 mAb-12438 SPDB-DM4 [288]
Anti-FGFR2/4 mAb 12438
Fibroblast growth factor receptor 2 (FGFR2); Fibroblast growth factor receptor 4 (FGFR4)
Mertansine DM4
N-succinimidyl 4-(2-pyridyldithio) butanoate (SPDB)
Anti-FGFR2/4 mAb-12425 CX1-1-DM1 [288]
Anti-FGFR2/4 mAb 12425
Fibroblast growth factor receptor 2 (FGFR2); Fibroblast growth factor receptor 4 (FGFR4)
Mertansine DM1
2,5-Dioxopyrrolidin-1-yl 17-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)-5,8,11,14-tetraazaheptadecan-1-oate (CX1-1)
Anti-FGFR2/4 mAb-14629 CX1-1-DM1 [288]
Anti-FGFR2/4 mAb 14629
Fibroblast growth factor receptor 2 (FGFR2); Fibroblast growth factor receptor 4 (FGFR4)
Mertansine DM1
2,5-Dioxopyrrolidin-1-yl 17-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)-5,8,11,14-tetraazaheptadecan-1-oate (CX1-1)
Anti-FGFR2/4 mAb-20562 CX1-1-DM1 [288]
Anti-FGFR2/4 mAb 20562
Fibroblast growth factor receptor 2 (FGFR2); Fibroblast growth factor receptor 4 (FGFR4)
Mertansine DM1
2,5-Dioxopyrrolidin-1-yl 17-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)-5,8,11,14-tetraazaheptadecan-1-oate (CX1-1)
Anti-FGFR2/4 mAb-20811 CX1-1-DM1 [288]
Anti-FGFR2/4 mAb 20811
Fibroblast growth factor receptor 2 (FGFR2); Fibroblast growth factor receptor 4 (FGFR4)
Mertansine DM1
2,5-Dioxopyrrolidin-1-yl 17-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)-5,8,11,14-tetraazaheptadecan-1-oate (CX1-1)
Anti-FGFR2/4 mAb-12422 CX1-1-DM1 [288]
Anti-FGFR2/4 mAb 12422
Fibroblast growth factor receptor 2 (FGFR2); Fibroblast growth factor receptor 4 (FGFR4)
Mertansine DM1
2,5-Dioxopyrrolidin-1-yl 17-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)-5,8,11,14-tetraazaheptadecan-1-oate (CX1-1)
Anti-FGFR2/4 mAb-12439 CX1-1-DM1 [288]
Anti-FGFR2/4 mAb 12439
Fibroblast growth factor receptor 2 (FGFR2); Fibroblast growth factor receptor 4 (FGFR4)
Mertansine DM1
2,5-Dioxopyrrolidin-1-yl 17-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)-5,8,11,14-tetraazaheptadecan-1-oate (CX1-1)
Anti-FGFR2 mAb-10164 CX1-1-DM1 [288]
Anti-FGFR2 mAb 10164
Fibroblast growth factor receptor 2 (FGFR2)
Mertansine DM1
2,5-Dioxopyrrolidin-1-yl 17-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)-5,8,11,14-tetraazaheptadecan-1-oate (CX1-1)
Anti-FGFR2 mAb-10220 CX1-1-DM1 [288]
Anti-FGFR2 mAb 10220
Fibroblast growth factor receptor 2 (FGFR2)
Mertansine DM1
2,5-Dioxopyrrolidin-1-yl 17-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)-5,8,11,14-tetraazaheptadecan-1-oate (CX1-1)
Anti-FGFR2 mAb-10846 CX1-1-DM1 [288]
Anti-FGFR2 mAb 10846
Fibroblast growth factor receptor 2 (FGFR2)
Mertansine DM1
2,5-Dioxopyrrolidin-1-yl 17-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)-5,8,11,14-tetraazaheptadecan-1-oate (CX1-1)
Anti-FGFR2/4 mAb-10918 CX1-1-DM1 [288]
Anti-FGFR2/4 mAb 10918
Fibroblast growth factor receptor 2 (FGFR2); Fibroblast growth factor receptor 4 (FGFR4)
Mertansine DM1
2,5-Dioxopyrrolidin-1-yl 17-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)-5,8,11,14-tetraazaheptadecan-1-oate (CX1-1)
Anti-FGFR2/4 mAb-10923 CX1-1-DM1 [288]
Anti-FGFR2/4 mAb 10923
Fibroblast growth factor receptor 2 (FGFR2); Fibroblast growth factor receptor 4 (FGFR4)
Mertansine DM1
2,5-Dioxopyrrolidin-1-yl 17-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)-5,8,11,14-tetraazaheptadecan-1-oate (CX1-1)
Anti-FGFR2/4 mAb-11722 CX1-1-DM1 [288]
Anti-FGFR2/4 mAb 11722
Fibroblast growth factor receptor 2 (FGFR2); Fibroblast growth factor receptor 4 (FGFR4)
Mertansine DM1
2,5-Dioxopyrrolidin-1-yl 17-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)-5,8,11,14-tetraazaheptadecan-1-oate (CX1-1)
Anti-FGFR2 mAb-11723 CX1-1-DM1 [288]
Anti-FGFR2 mAb 11723
Fibroblast growth factor receptor 2 (FGFR2)
Mertansine DM1
2,5-Dioxopyrrolidin-1-yl 17-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)-5,8,11,14-tetraazaheptadecan-1-oate (CX1-1)
Anti-FGFR2 mAb-11725 CX1-1-DM1 [288]
Anti-FGFR2 mAb 11725
Fibroblast growth factor receptor 2 (FGFR2)
Mertansine DM1
2,5-Dioxopyrrolidin-1-yl 17-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)-5,8,11,14-tetraazaheptadecan-1-oate (CX1-1)
Anti-FGFR2 mAb-12433 CX1-1-DM1 [288]
Anti-FGFR2 mAb 12433
Fibroblast growth factor receptor 2 (FGFR2)
Mertansine DM1
2,5-Dioxopyrrolidin-1-yl 17-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)-5,8,11,14-tetraazaheptadecan-1-oate (CX1-1)
Anti-FGFR2 mAb-12931 CX1-1-DM1 [288]
Anti-FGFR2 mAb 12931
Fibroblast growth factor receptor 2 (FGFR2)
Mertansine DM1
2,5-Dioxopyrrolidin-1-yl 17-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)-5,8,11,14-tetraazaheptadecan-1-oate (CX1-1)
Anti-FGFR2 mAb-12944 CX1-1-DM1 [288]
Anti-FGFR2 mAb 12944
Fibroblast growth factor receptor 2 (FGFR2)
Mertansine DM1
2,5-Dioxopyrrolidin-1-yl 17-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)-5,8,11,14-tetraazaheptadecan-1-oate (CX1-1)
Anti-FGFR2 mAb-12947 CX1-1-DM1 [288]
Anti-FGFR2 mAb 12947
Fibroblast growth factor receptor 2 (FGFR2)
Mertansine DM1
2,5-Dioxopyrrolidin-1-yl 17-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)-5,8,11,14-tetraazaheptadecan-1-oate (CX1-1)
Anti-FGFR2/4 mAb-10553 CX1-1-DM1 [288]
Anti-FGFR2/4 mAb 10553
Fibroblast growth factor receptor 2 (FGFR2); Fibroblast growth factor receptor 4 (FGFR4)
Mertansine DM1
2,5-Dioxopyrrolidin-1-yl 17-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)-5,8,11,14-tetraazaheptadecan-1-oate (CX1-1)
Anti-FGFR2/4 mAb-10554 CX1-1-DM1 [288]
Anti-FGFR2/4 mAb 10554
Fibroblast growth factor receptor 2 (FGFR2); Fibroblast growth factor receptor 4 (FGFR4)
Mertansine DM1
2,5-Dioxopyrrolidin-1-yl 17-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)-5,8,11,14-tetraazaheptadecan-1-oate (CX1-1)
Anti-FGFR2/4 mAb-10925 CX1-1-DM1 [288]
Anti-FGFR2/4 mAb 10925
Fibroblast growth factor receptor 2 (FGFR2); Fibroblast growth factor receptor 4 (FGFR4)
Mertansine DM1
2,5-Dioxopyrrolidin-1-yl 17-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)-5,8,11,14-tetraazaheptadecan-1-oate (CX1-1)
Anti-FGFR2/4 mAb-10729 CX1-1-DM1 [288]
Anti-FGFR2/4 mAb 10729
Fibroblast growth factor receptor 2 (FGFR2); Fibroblast growth factor receptor 4 (FGFR4)
Mertansine DM1
2,5-Dioxopyrrolidin-1-yl 17-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)-5,8,11,14-tetraazaheptadecan-1-oate (CX1-1)
Anti-FGFR2/4 mAb-12435 CX1-1-DM1 [288]
Anti-FGFR2/4 mAb 12435
Fibroblast growth factor receptor 2 (FGFR2); Fibroblast growth factor receptor 4 (FGFR4)
Mertansine DM1
2,5-Dioxopyrrolidin-1-yl 17-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)-5,8,11,14-tetraazaheptadecan-1-oate (CX1-1)
Anti-FGFR2/4 mAb-12438 CX1-1-DM1 [288]
Anti-FGFR2/4 mAb 12438
Fibroblast growth factor receptor 2 (FGFR2); Fibroblast growth factor receptor 4 (FGFR4)
Mertansine DM1
2,5-Dioxopyrrolidin-1-yl 17-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)-5,8,11,14-tetraazaheptadecan-1-oate (CX1-1)
Anti-FGFR2/4 mAb-12425 SSNPP-DM3 [288]
Anti-FGFR2/4 mAb 12425
Fibroblast growth factor receptor 2 (FGFR2); Fibroblast growth factor receptor 4 (FGFR4)
Maytansinoid DM3
Sulfosuccinimidyl-N-succinimidyl-4-(5-nitro-2-pyridyldithio) pentanoate (SSNPP)
Anti-FGFR2/4 mAb-14629 SSNPP-DM3 [288]
Anti-FGFR2/4 mAb 14629
Fibroblast growth factor receptor 2 (FGFR2); Fibroblast growth factor receptor 4 (FGFR4)
Maytansinoid DM3
Sulfosuccinimidyl-N-succinimidyl-4-(5-nitro-2-pyridyldithio) pentanoate (SSNPP)
Anti-FGFR2/4 mAb-20562 SSNPP-DM3 [288]
Anti-FGFR2/4 mAb 20562
Fibroblast growth factor receptor 2 (FGFR2); Fibroblast growth factor receptor 4 (FGFR4)
Maytansinoid DM3
Sulfosuccinimidyl-N-succinimidyl-4-(5-nitro-2-pyridyldithio) pentanoate (SSNPP)
Anti-FGFR2/4 mAb-20811 SSNPP-DM3 [288]
Anti-FGFR2/4 mAb 20811
Fibroblast growth factor receptor 2 (FGFR2); Fibroblast growth factor receptor 4 (FGFR4)
Maytansinoid DM3
Sulfosuccinimidyl-N-succinimidyl-4-(5-nitro-2-pyridyldithio) pentanoate (SSNPP)
Anti-FGFR2/4 mAb-12422 SSNPP-DM3 [288]
Anti-FGFR2/4 mAb 12422
Fibroblast growth factor receptor 2 (FGFR2); Fibroblast growth factor receptor 4 (FGFR4)
Maytansinoid DM3
Sulfosuccinimidyl-N-succinimidyl-4-(5-nitro-2-pyridyldithio) pentanoate (SSNPP)
Anti-FGFR2/4 mAb-12439 SSNPP-DM3 [288]
Anti-FGFR2/4 mAb 12439
Fibroblast growth factor receptor 2 (FGFR2); Fibroblast growth factor receptor 4 (FGFR4)
Maytansinoid DM3
Sulfosuccinimidyl-N-succinimidyl-4-(5-nitro-2-pyridyldithio) pentanoate (SSNPP)
Anti-FGFR2 mAb-10164 SSNPP-DM3 [288]
Anti-FGFR2 mAb 10164
Fibroblast growth factor receptor 2 (FGFR2)
Maytansinoid DM3
Sulfosuccinimidyl-N-succinimidyl-4-(5-nitro-2-pyridyldithio) pentanoate (SSNPP)
Anti-FGFR2 mAb-10220 SSNPP-DM3 [288]
Anti-FGFR2 mAb 10220
Fibroblast growth factor receptor 2 (FGFR2)
Maytansinoid DM3
Sulfosuccinimidyl-N-succinimidyl-4-(5-nitro-2-pyridyldithio) pentanoate (SSNPP)
Anti-FGFR2 mAb-10846 SSNPP-DM3 [288]
Anti-FGFR2 mAb 10846
Fibroblast growth factor receptor 2 (FGFR2)
Maytansinoid DM3
Sulfosuccinimidyl-N-succinimidyl-4-(5-nitro-2-pyridyldithio) pentanoate (SSNPP)
Anti-FGFR2/4 mAb-10918 SSNPP-DM3 [288]
Anti-FGFR2/4 mAb 10918
Fibroblast growth factor receptor 2 (FGFR2); Fibroblast growth factor receptor 4 (FGFR4)
Maytansinoid DM3
Sulfosuccinimidyl-N-succinimidyl-4-(5-nitro-2-pyridyldithio) pentanoate (SSNPP)
Anti-FGFR2/4 mAb-10923 SSNPP-DM3 [288]
Anti-FGFR2/4 mAb 10923
Fibroblast growth factor receptor 2 (FGFR2); Fibroblast growth factor receptor 4 (FGFR4)
Maytansinoid DM3
Sulfosuccinimidyl-N-succinimidyl-4-(5-nitro-2-pyridyldithio) pentanoate (SSNPP)
Anti-FGFR2/4 mAb-11722 SSNPP-DM3 [288]
Anti-FGFR2/4 mAb 11722
Fibroblast growth factor receptor 2 (FGFR2); Fibroblast growth factor receptor 4 (FGFR4)
Maytansinoid DM3
Sulfosuccinimidyl-N-succinimidyl-4-(5-nitro-2-pyridyldithio) pentanoate (SSNPP)
Anti-FGFR2 mAb-11723 SSNPP-DM3 [288]
Anti-FGFR2 mAb 11723
Fibroblast growth factor receptor 2 (FGFR2)
Maytansinoid DM3
Sulfosuccinimidyl-N-succinimidyl-4-(5-nitro-2-pyridyldithio) pentanoate (SSNPP)
Anti-FGFR2 mAb-11725 SSNPP-DM3 [288]
Anti-FGFR2 mAb 11725
Fibroblast growth factor receptor 2 (FGFR2)
Maytansinoid DM3
Sulfosuccinimidyl-N-succinimidyl-4-(5-nitro-2-pyridyldithio) pentanoate (SSNPP)
Anti-FGFR2 mAb-12433 SSNPP-DM3 [288]
Anti-FGFR2 mAb 12433
Fibroblast growth factor receptor 2 (FGFR2)
Maytansinoid DM3
Sulfosuccinimidyl-N-succinimidyl-4-(5-nitro-2-pyridyldithio) pentanoate (SSNPP)
Anti-FGFR2 mAb-12931 SSNPP-DM3 [288]
Anti-FGFR2 mAb 12931
Fibroblast growth factor receptor 2 (FGFR2)
Maytansinoid DM3
Sulfosuccinimidyl-N-succinimidyl-4-(5-nitro-2-pyridyldithio) pentanoate (SSNPP)
Anti-FGFR2 mAb-12944 SSNPP-DM3 [288]
Anti-FGFR2 mAb 12944
Fibroblast growth factor receptor 2 (FGFR2)
Maytansinoid DM3
Sulfosuccinimidyl-N-succinimidyl-4-(5-nitro-2-pyridyldithio) pentanoate (SSNPP)
Anti-FGFR2 mAb-12947 SSNPP-DM3 [288]
Anti-FGFR2 mAb 12947
Fibroblast growth factor receptor 2 (FGFR2)
Maytansinoid DM3
Sulfosuccinimidyl-N-succinimidyl-4-(5-nitro-2-pyridyldithio) pentanoate (SSNPP)
Anti-FGFR2/4 mAb-10553 SSNPP-DM3 [288]
Anti-FGFR2/4 mAb 10553
Fibroblast growth factor receptor 2 (FGFR2); Fibroblast growth factor receptor 4 (FGFR4)
Maytansinoid DM3
Sulfosuccinimidyl-N-succinimidyl-4-(5-nitro-2-pyridyldithio) pentanoate (SSNPP)
Anti-FGFR2/4 mAb-10554 SSNPP-DM3 [288]
Anti-FGFR2/4 mAb 10554
Fibroblast growth factor receptor 2 (FGFR2); Fibroblast growth factor receptor 4 (FGFR4)
Maytansinoid DM3
Sulfosuccinimidyl-N-succinimidyl-4-(5-nitro-2-pyridyldithio) pentanoate (SSNPP)
Anti-FGFR2/4 mAb-10925 SSNPP-DM3 [288]
Anti-FGFR2/4 mAb 10925
Fibroblast growth factor receptor 2 (FGFR2); Fibroblast growth factor receptor 4 (FGFR4)
Maytansinoid DM3
Sulfosuccinimidyl-N-succinimidyl-4-(5-nitro-2-pyridyldithio) pentanoate (SSNPP)
Anti-FGFR2/4 mAb-10729 SSNPP-DM3 [288]
Anti-FGFR2/4 mAb 10729
Fibroblast growth factor receptor 2 (FGFR2); Fibroblast growth factor receptor 4 (FGFR4)
Maytansinoid DM3
Sulfosuccinimidyl-N-succinimidyl-4-(5-nitro-2-pyridyldithio) pentanoate (SSNPP)
Anti-FGFR2/4 mAb-12435 SSNPP-DM3 [288]
Anti-FGFR2/4 mAb 12435
Fibroblast growth factor receptor 2 (FGFR2); Fibroblast growth factor receptor 4 (FGFR4)
Maytansinoid DM3
Sulfosuccinimidyl-N-succinimidyl-4-(5-nitro-2-pyridyldithio) pentanoate (SSNPP)
Anti-FGFR2/4 mAb-12438 SSNPP-DM3 [288]
Anti-FGFR2/4 mAb 12438
Fibroblast growth factor receptor 2 (FGFR2); Fibroblast growth factor receptor 4 (FGFR4)
Maytansinoid DM3
Sulfosuccinimidyl-N-succinimidyl-4-(5-nitro-2-pyridyldithio) pentanoate (SSNPP)
Anti-FGFR2/4 mAb-12425 SPP-DM1 [288]
Anti-FGFR2/4 mAb 12425
Fibroblast growth factor receptor 2 (FGFR2); Fibroblast growth factor receptor 4 (FGFR4)
Mertansine DM1
N-succinimidyl 4-(2-pyridyldithio) pentanoate (SPP)
Anti-FGFR2/4 mAb-14629 SPP-DM1 [288]
Anti-FGFR2/4 mAb 14629
Fibroblast growth factor receptor 2 (FGFR2); Fibroblast growth factor receptor 4 (FGFR4)
Mertansine DM1
N-succinimidyl 4-(2-pyridyldithio) pentanoate (SPP)
Anti-FGFR2/4 mAb-20562 SPP-DM1 [288]
Anti-FGFR2/4 mAb 20562
Fibroblast growth factor receptor 2 (FGFR2); Fibroblast growth factor receptor 4 (FGFR4)
Mertansine DM1
N-succinimidyl 4-(2-pyridyldithio) pentanoate (SPP)
Anti-FGFR2/4 mAb-20811 SPP-DM1 [288]
Anti-FGFR2/4 mAb 20811
Fibroblast growth factor receptor 2 (FGFR2); Fibroblast growth factor receptor 4 (FGFR4)
Mertansine DM1
N-succinimidyl 4-(2-pyridyldithio) pentanoate (SPP)
Anti-FGFR2/4 mAb-12422 SPP-DM1 [288]
Anti-FGFR2/4 mAb 12422
Fibroblast growth factor receptor 2 (FGFR2); Fibroblast growth factor receptor 4 (FGFR4)
Mertansine DM1
N-succinimidyl 4-(2-pyridyldithio) pentanoate (SPP)
Anti-FGFR2/4 mAb-12439 SPP-DM1 [288]
Anti-FGFR2/4 mAb 12439
Fibroblast growth factor receptor 2 (FGFR2); Fibroblast growth factor receptor 4 (FGFR4)
Mertansine DM1
N-succinimidyl 4-(2-pyridyldithio) pentanoate (SPP)
Anti-FGFR2 mAb-10164 SPP-DM1 [288]
Anti-FGFR2 mAb 10164
Fibroblast growth factor receptor 2 (FGFR2)
Mertansine DM1
N-succinimidyl 4-(2-pyridyldithio) pentanoate (SPP)
Anti-FGFR2 mAb-10220 SPP-DM1 [288]
Anti-FGFR2 mAb 10220
Fibroblast growth factor receptor 2 (FGFR2)
Mertansine DM1
N-succinimidyl 4-(2-pyridyldithio) pentanoate (SPP)
Anti-FGFR2 mAb-10846 SPP-DM1 [288]
Anti-FGFR2 mAb 10846
Fibroblast growth factor receptor 2 (FGFR2)
Mertansine DM1
N-succinimidyl 4-(2-pyridyldithio) pentanoate (SPP)
Anti-FGFR2/4 mAb-10918 SPP-DM1 [288]
Anti-FGFR2/4 mAb 10918
Fibroblast growth factor receptor 2 (FGFR2); Fibroblast growth factor receptor 4 (FGFR4)
Mertansine DM1
N-succinimidyl 4-(2-pyridyldithio) pentanoate (SPP)
Anti-FGFR2/4 mAb-10923 SPP-DM1 [288]
Anti-FGFR2/4 mAb 10923
Fibroblast growth factor receptor 2 (FGFR2); Fibroblast growth factor receptor 4 (FGFR4)
Mertansine DM1
N-succinimidyl 4-(2-pyridyldithio) pentanoate (SPP)
Anti-FGFR2/4 mAb-11722 SPP-DM1 [288]
Anti-FGFR2/4 mAb 11722
Fibroblast growth factor receptor 2 (FGFR2); Fibroblast growth factor receptor 4 (FGFR4)
Mertansine DM1
N-succinimidyl 4-(2-pyridyldithio) pentanoate (SPP)
Anti-FGFR2 mAb-11723 SPP-DM1 [288]
Anti-FGFR2 mAb 11723
Fibroblast growth factor receptor 2 (FGFR2)
Mertansine DM1
N-succinimidyl 4-(2-pyridyldithio) pentanoate (SPP)
Anti-FGFR2 mAb-11725 SPP-DM1 [288]
Anti-FGFR2 mAb 11725
Fibroblast growth factor receptor 2 (FGFR2)
Mertansine DM1
N-succinimidyl 4-(2-pyridyldithio) pentanoate (SPP)
Anti-FGFR2 mAb-12433 SPP-DM1 [288]
Anti-FGFR2 mAb 12433
Fibroblast growth factor receptor 2 (FGFR2)
Mertansine DM1
N-succinimidyl 4-(2-pyridyldithio) pentanoate (SPP)
Anti-FGFR2 mAb-12931 SPP-DM1 [288]
Anti-FGFR2 mAb 12931
Fibroblast growth factor receptor 2 (FGFR2)
Mertansine DM1
N-succinimidyl 4-(2-pyridyldithio) pentanoate (SPP)
Anti-FGFR2 mAb-12944 SPP-DM1 [288]
Anti-FGFR2 mAb 12944
Fibroblast growth factor receptor 2 (FGFR2)
Mertansine DM1
N-succinimidyl 4-(2-pyridyldithio) pentanoate (SPP)
Anti-FGFR2 mAb-12947 SPP-DM1 [288]
Anti-FGFR2 mAb 12947
Fibroblast growth factor receptor 2 (FGFR2)
Mertansine DM1
N-succinimidyl 4-(2-pyridyldithio) pentanoate (SPP)
Anti-FGFR2/4 mAb-10553 SPP-DM1 [288]
Anti-FGFR2/4 mAb 10553
Fibroblast growth factor receptor 2 (FGFR2); Fibroblast growth factor receptor 4 (FGFR4)
Mertansine DM1
N-succinimidyl 4-(2-pyridyldithio) pentanoate (SPP)
Anti-FGFR2/4 mAb-10554 SPP-DM1 [288]
Anti-FGFR2/4 mAb 10554
Fibroblast growth factor receptor 2 (FGFR2); Fibroblast growth factor receptor 4 (FGFR4)
Mertansine DM1
N-succinimidyl 4-(2-pyridyldithio) pentanoate (SPP)
Anti-FGFR2/4 mAb-10925 SPP-DM1 [288]
Anti-FGFR2/4 mAb 10925
Fibroblast growth factor receptor 2 (FGFR2); Fibroblast growth factor receptor 4 (FGFR4)
Mertansine DM1
N-succinimidyl 4-(2-pyridyldithio) pentanoate (SPP)
Anti-FGFR2/4 mAb-10729 SPP-DM1 [288]
Anti-FGFR2/4 mAb 10729
Fibroblast growth factor receptor 2 (FGFR2); Fibroblast growth factor receptor 4 (FGFR4)
Mertansine DM1
N-succinimidyl 4-(2-pyridyldithio) pentanoate (SPP)
Anti-FGFR2/4 mAb-12435 SPP-DM1 [288]
Anti-FGFR2/4 mAb 12435
Fibroblast growth factor receptor 2 (FGFR2); Fibroblast growth factor receptor 4 (FGFR4)
Mertansine DM1
N-succinimidyl 4-(2-pyridyldithio) pentanoate (SPP)
Anti-FGFR2/4 mAb-12438 SPP-DM1 [288]
Anti-FGFR2/4 mAb 12438
Fibroblast growth factor receptor 2 (FGFR2); Fibroblast growth factor receptor 4 (FGFR4)
Mertansine DM1
N-succinimidyl 4-(2-pyridyldithio) pentanoate (SPP)
Anti-FGFR2/4 mAb-12425 Sulfo-SPDB-DM4 [288]
Anti-FGFR2/4 mAb 12425
Fibroblast growth factor receptor 2 (FGFR2); Fibroblast growth factor receptor 4 (FGFR4)
Mertansine DM4
Sulfo-SPDB
Anti-FGFR2/4 mAb-14629 Sulfo-SPDB-DM4 [288]
Anti-FGFR2/4 mAb 14629
Fibroblast growth factor receptor 2 (FGFR2); Fibroblast growth factor receptor 4 (FGFR4)
Mertansine DM4
Sulfo-SPDB
Anti-FGFR2/4 mAb-20562 Sulfo-SPDB-DM4 [288]
Anti-FGFR2/4 mAb 20562
Fibroblast growth factor receptor 2 (FGFR2); Fibroblast growth factor receptor 4 (FGFR4)
Mertansine DM4
Sulfo-SPDB
Anti-FGFR2/4 mAb-20811 Sulfo-SPDB-DM4 [288]
Anti-FGFR2/4 mAb 20811
Fibroblast growth factor receptor 2 (FGFR2); Fibroblast growth factor receptor 4 (FGFR4)
Mertansine DM4
Sulfo-SPDB
Anti-FGFR2/4 mAb-12422 Sulfo-SPDB-DM4 [288]
Anti-FGFR2/4 mAb 12422
Fibroblast growth factor receptor 2 (FGFR2); Fibroblast growth factor receptor 4 (FGFR4)
Mertansine DM4
Sulfo-SPDB
Anti-FGFR2/4 mAb-12439 Sulfo-SPDB-DM4 [288]
Anti-FGFR2/4 mAb 12439
Fibroblast growth factor receptor 2 (FGFR2); Fibroblast growth factor receptor 4 (FGFR4)
Mertansine DM4
Sulfo-SPDB
Anti-FGFR2 mAb-10164 Sulfo-SPDB-DM4 [288]
Anti-FGFR2 mAb 10164
Fibroblast growth factor receptor 2 (FGFR2)
Mertansine DM4
Sulfo-SPDB
Anti-FGFR2 mAb-10220 Sulfo-SPDB-DM4 [288]
Anti-FGFR2 mAb 10220
Fibroblast growth factor receptor 2 (FGFR2)
Mertansine DM4
Sulfo-SPDB
Anti-FGFR2 mAb-10846 Sulfo-SPDB-DM4 [288]
Anti-FGFR2 mAb 10846
Fibroblast growth factor receptor 2 (FGFR2)
Mertansine DM4
Sulfo-SPDB
Anti-FGFR2/4 mAb-10918 Sulfo-SPDB-DM4 [288]
Anti-FGFR2/4 mAb 10918
Fibroblast growth factor receptor 2 (FGFR2); Fibroblast growth factor receptor 4 (FGFR4)
Mertansine DM4
Sulfo-SPDB
Anti-FGFR2/4 mAb-10923 Sulfo-SPDB-DM4 [288]
Anti-FGFR2/4 mAb 10923
Fibroblast growth factor receptor 2 (FGFR2); Fibroblast growth factor receptor 4 (FGFR4)
Mertansine DM4
Sulfo-SPDB
Anti-FGFR2/4 mAb-11722 Sulfo-SPDB-DM4 [288]
Anti-FGFR2/4 mAb 11722
Fibroblast growth factor receptor 2 (FGFR2); Fibroblast growth factor receptor 4 (FGFR4)
Mertansine DM4
Sulfo-SPDB
Anti-FGFR2 mAb-11723 Sulfo-SPDB-DM4 [288]
Anti-FGFR2 mAb 11723
Fibroblast growth factor receptor 2 (FGFR2)
Mertansine DM4
Sulfo-SPDB
Anti-FGFR2 mAb-11725 Sulfo-SPDB-DM4 [288]
Anti-FGFR2 mAb 11725
Fibroblast growth factor receptor 2 (FGFR2)
Mertansine DM4
Sulfo-SPDB
Anti-FGFR2 mAb-12433 Sulfo-SPDB-DM4 [288]
Anti-FGFR2 mAb 12433
Fibroblast growth factor receptor 2 (FGFR2)
Mertansine DM4
Sulfo-SPDB
Anti-FGFR2 mAb-12931 Sulfo-SPDB-DM4 [288]
Anti-FGFR2 mAb 12931
Fibroblast growth factor receptor 2 (FGFR2)
Mertansine DM4
Sulfo-SPDB
Anti-FGFR2 mAb-12944 Sulfo-SPDB-DM4 [288]
Anti-FGFR2 mAb 12944
Fibroblast growth factor receptor 2 (FGFR2)
Mertansine DM4
Sulfo-SPDB
Anti-FGFR2 mAb-12947 Sulfo-SPDB-DM4 [288]
Anti-FGFR2 mAb 12947
Fibroblast growth factor receptor 2 (FGFR2)
Mertansine DM4
Sulfo-SPDB
Anti-FGFR2/4 mAb-10553 Sulfo-SPDB-DM4 [288]
Anti-FGFR2/4 mAb 10553
Fibroblast growth factor receptor 2 (FGFR2); Fibroblast growth factor receptor 4 (FGFR4)
Mertansine DM4
Sulfo-SPDB
Anti-FGFR2/4 mAb-10554 Sulfo-SPDB-DM4 [288]
Anti-FGFR2/4 mAb 10554
Fibroblast growth factor receptor 2 (FGFR2); Fibroblast growth factor receptor 4 (FGFR4)
Mertansine DM4
Sulfo-SPDB
Anti-FGFR2/4 mAb-10925 Sulfo-SPDB-DM4 [288]
Anti-FGFR2/4 mAb 10925
Fibroblast growth factor receptor 2 (FGFR2); Fibroblast growth factor receptor 4 (FGFR4)
Mertansine DM4
Sulfo-SPDB
Anti-FGFR2/4 mAb-10729 Sulfo-SPDB-DM4 [288]
Anti-FGFR2/4 mAb 10729
Fibroblast growth factor receptor 2 (FGFR2); Fibroblast growth factor receptor 4 (FGFR4)
Mertansine DM4
Sulfo-SPDB
Anti-FGFR2/4 mAb-12435 Sulfo-SPDB-DM4 [288]
Anti-FGFR2/4 mAb 12435
Fibroblast growth factor receptor 2 (FGFR2); Fibroblast growth factor receptor 4 (FGFR4)
Mertansine DM4
Sulfo-SPDB
Anti-FGFR2/4 mAb-12438 Sulfo-SPDB-DM4 [288]
Anti-FGFR2/4 mAb 12438
Fibroblast growth factor receptor 2 (FGFR2); Fibroblast growth factor receptor 4 (FGFR4)
Mertansine DM4
Sulfo-SPDB
Anti-FGFR2/4 mAb-12425 SPDP-DM1 [288]
Anti-FGFR2/4 mAb 12425
Fibroblast growth factor receptor 2 (FGFR2); Fibroblast growth factor receptor 4 (FGFR4)
Mertansine DM1
N-succinimidyl 3-(2-pyridyldithio) propionate (SPDP)
Anti-FGFR2/4 mAb-14629 SPDP-DM1 [288]
Anti-FGFR2/4 mAb 14629
Fibroblast growth factor receptor 2 (FGFR2); Fibroblast growth factor receptor 4 (FGFR4)
Mertansine DM1
N-succinimidyl 3-(2-pyridyldithio) propionate (SPDP)
Anti-FGFR2/4 mAb-20562 SPDP-DM1 [288]
Anti-FGFR2/4 mAb 20562
Fibroblast growth factor receptor 2 (FGFR2); Fibroblast growth factor receptor 4 (FGFR4)
Mertansine DM1
N-succinimidyl 3-(2-pyridyldithio) propionate (SPDP)
Anti-FGFR2/4 mAb-20811 SPDP-DM1 [288]
Anti-FGFR2/4 mAb 20811
Fibroblast growth factor receptor 2 (FGFR2); Fibroblast growth factor receptor 4 (FGFR4)
Mertansine DM1
N-succinimidyl 3-(2-pyridyldithio) propionate (SPDP)
Anti-FGFR2/4 mAb-12422 SPDP-DM1 [288]
Anti-FGFR2/4 mAb 12422
Fibroblast growth factor receptor 2 (FGFR2); Fibroblast growth factor receptor 4 (FGFR4)
Mertansine DM1
N-succinimidyl 3-(2-pyridyldithio) propionate (SPDP)
Anti-FGFR2/4 mAb-12439 SPDP-DM1 [288]
Anti-FGFR2/4 mAb 12439
Fibroblast growth factor receptor 2 (FGFR2); Fibroblast growth factor receptor 4 (FGFR4)
Mertansine DM1
N-succinimidyl 3-(2-pyridyldithio) propionate (SPDP)
Anti-FGFR2 mAb-10164 SPDP-DM1 [288]
Anti-FGFR2 mAb 10164
Fibroblast growth factor receptor 2 (FGFR2)
Mertansine DM1
N-succinimidyl 3-(2-pyridyldithio) propionate (SPDP)
Anti-FGFR2 mAb-10220 SPDP-DM1 [288]
Anti-FGFR2 mAb 10220
Fibroblast growth factor receptor 2 (FGFR2)
Mertansine DM1
N-succinimidyl 3-(2-pyridyldithio) propionate (SPDP)
Anti-FGFR2 mAb-10846 SPDP-DM1 [288]
Anti-FGFR2 mAb 10846
Fibroblast growth factor receptor 2 (FGFR2)
Mertansine DM1
N-succinimidyl 3-(2-pyridyldithio) propionate (SPDP)
Anti-FGFR2/4 mAb-10918 SPDP-DM1 [288]
Anti-FGFR2/4 mAb 10918
Fibroblast growth factor receptor 2 (FGFR2); Fibroblast growth factor receptor 4 (FGFR4)
Mertansine DM1
N-succinimidyl 3-(2-pyridyldithio) propionate (SPDP)
Anti-FGFR2/4 mAb-10923 SPDP-DM1 [288]
Anti-FGFR2/4 mAb 10923
Fibroblast growth factor receptor 2 (FGFR2); Fibroblast growth factor receptor 4 (FGFR4)
Mertansine DM1
N-succinimidyl 3-(2-pyridyldithio) propionate (SPDP)
Anti-FGFR2/4 mAb-11722 SPDP-DM1 [288]
Anti-FGFR2/4 mAb 11722
Fibroblast growth factor receptor 2 (FGFR2); Fibroblast growth factor receptor 4 (FGFR4)
Mertansine DM1
N-succinimidyl 3-(2-pyridyldithio) propionate (SPDP)
Anti-FGFR2 mAb-11723 SPDP-DM1 [288]
Anti-FGFR2 mAb 11723
Fibroblast growth factor receptor 2 (FGFR2)
Mertansine DM1
N-succinimidyl 3-(2-pyridyldithio) propionate (SPDP)
Anti-FGFR2 mAb-11725 SPDP-DM1 [288]
Anti-FGFR2 mAb 11725
Fibroblast growth factor receptor 2 (FGFR2)
Mertansine DM1
N-succinimidyl 3-(2-pyridyldithio) propionate (SPDP)
Anti-FGFR2 mAb-12433 SPDP-DM1 [288]
Anti-FGFR2 mAb 12433
Fibroblast growth factor receptor 2 (FGFR2)
Mertansine DM1
N-succinimidyl 3-(2-pyridyldithio) propionate (SPDP)
Anti-FGFR2 mAb-12931 SPDP-DM1 [288]
Anti-FGFR2 mAb 12931
Fibroblast growth factor receptor 2 (FGFR2)
Mertansine DM1
N-succinimidyl 3-(2-pyridyldithio) propionate (SPDP)
Anti-FGFR2 mAb-12944 SPDP-DM1 [288]
Anti-FGFR2 mAb 12944
Fibroblast growth factor receptor 2 (FGFR2)
Mertansine DM1
N-succinimidyl 3-(2-pyridyldithio) propionate (SPDP)
Anti-FGFR2 mAb-12947 SPDP-DM1 [288]
Anti-FGFR2 mAb 12947
Fibroblast growth factor receptor 2 (FGFR2)
Mertansine DM1
N-succinimidyl 3-(2-pyridyldithio) propionate (SPDP)
Anti-FGFR2/4 mAb-10553 SPDP-DM1 [288]
Anti-FGFR2/4 mAb 10553
Fibroblast growth factor receptor 2 (FGFR2); Fibroblast growth factor receptor 4 (FGFR4)
Mertansine DM1
N-succinimidyl 3-(2-pyridyldithio) propionate (SPDP)
Anti-FGFR2/4 mAb-10554 SPDP-DM1 [288]
Anti-FGFR2/4 mAb 10554
Fibroblast growth factor receptor 2 (FGFR2); Fibroblast growth factor receptor 4 (FGFR4)
Mertansine DM1
N-succinimidyl 3-(2-pyridyldithio) propionate (SPDP)
Anti-FGFR2/4 mAb-10925 SPDP-DM1 [288]
Anti-FGFR2/4 mAb 10925
Fibroblast growth factor receptor 2 (FGFR2); Fibroblast growth factor receptor 4 (FGFR4)
Mertansine DM1
N-succinimidyl 3-(2-pyridyldithio) propionate (SPDP)
Anti-FGFR2/4 mAb-10729 SPDP-DM1 [288]
Anti-FGFR2/4 mAb 10729
Fibroblast growth factor receptor 2 (FGFR2); Fibroblast growth factor receptor 4 (FGFR4)
Mertansine DM1
N-succinimidyl 3-(2-pyridyldithio) propionate (SPDP)
Anti-FGFR2/4 mAb-12435 SPDP-DM1 [288]
Anti-FGFR2/4 mAb 12435
Fibroblast growth factor receptor 2 (FGFR2); Fibroblast growth factor receptor 4 (FGFR4)
Mertansine DM1
N-succinimidyl 3-(2-pyridyldithio) propionate (SPDP)
Anti-FGFR2/4 mAb-12438 SPDP-DM1 [288]
Anti-FGFR2/4 mAb 12438
Fibroblast growth factor receptor 2 (FGFR2); Fibroblast growth factor receptor 4 (FGFR4)
Mertansine DM1
N-succinimidyl 3-(2-pyridyldithio) propionate (SPDP)
AbA-vcMMAE [289]
Anti-EGFR AbA
Epidermal growth factor receptor (EGFR)
Monomethyl auristatin E
Mc-Val-Cit-PABC
Ab1-mcMMAF [289]
Anti-EGFR Ab1
Epidermal growth factor receptor (EGFR)
Monomethyl auristatin F
Maleimido-caproyl
Ab3-mcMMAF [289]
Anti-EGFR Ab3
Epidermal growth factor receptor (EGFR)
Monomethyl auristatin F
Maleimido-caproyl
AbA-mcMMAE [289]
Anti-EGFR AbA
Epidermal growth factor receptor (EGFR)
Monomethyl auristatin E
Maleimido-caproyl
Investigative(Terminated)
Click To Hide/Show 12 ADC Related to This Stage
ADC Name Antibody Antigen Payload Linker ADC Info
Alpha-CD70-Mc-MMAF [290]
Chimeric Anti-CD70 Anti-ody
CD70 antigen (CD70)
Monomethyl auristatin E
Mc-Val-Cit-PABC
CD30-BTG-ADC [291]
Anti-CD30 mAb cAC10Q
Tumor necrosis factor receptor superfamily member 8 (TNFRSF8)
Monomethyl auristatin E
PEG3-benzotriazole-PEG-Val-Cit-PABC
Anti-TenB2 antibody drug conjugate [292]
Anti-TENB2 monoclonal Anti-ody (mAb)
Tomoregulin-2 (TMEFF2)
Monomethyl auristatin E
Mc-Val-Cit-PABC
Alpha-CD30-Val-Cit-MMAE [293]
Anti-CD30 alphaCD30-vcMMAE mAb
Tumor necrosis factor receptor superfamily member 8 (TNFRSF8)
Monomethyl auristatin E
Mc-Val-Cit-PABC
B-1453 [294]
Undisclosed
Tumor necrosis factor ligand superfamily member 10 (TNFSF10)
Monomethyl auristatin E
Mc-Val-Cit-PABC
B-1452 [294]
Undisclosed
B-lymphocyte antigen CD20 (MS4A1)
Monomethyl auristatin E
Mc-Val-Cit-PABC
EGFRvIII/MMAE antibody drug conjugate [295]
Undisclosed
Epidermal growth factor receptor variant III (EGFRvIII)
Monomethyl auristatin E
Undisclosed
C-met monoclonal antibody-drug conjugate [296]
STI-D0606
Hepatocyte growth factor receptor (MET)
Mertansine DM1
Undisclosed
Cetuximab based antibody-drug conjugate [297]
Cetuximab
Epidermal growth factor receptor (EGFR)
Mertansine DM1
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
FGFR2/FGFR4 dual targeting antibody-drug conjugate [298]
Undisclosed
Fibroblast growth factor receptor 2 (FGFR2); Fibroblast growth factor receptor 4 (FGFR4)
Mertansine DM1
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
Trastuzumab-dTSPEG-MMAF [299]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin F
dTSPEG
Fluorescent Antibody-Drug Conjugate [300]
Anti-CEA mAb MIC0101
Pregnancy-specific beta-1-glycoprotein 2 (PSG2)
Paclitaxel
Undisclosed
Investigative
Click To Hide/Show 900 ADC Related to This Stage
ADC Name Antibody Antigen Payload Linker ADC Info
ZA202500202A D04-Y180F404/K42/E161-LP23 [301]
D04-Y180F404/K42/E161
Inactive tyrosine-protein kinase transmembrane receptor ROR1 (ROR1)
SC209
DBCO-6,4 nnAA-B-Glucuronide-PEG12
ZA202500202A D04-Y180F404/K42/E161-LP22 [301]
D04-Y180F404/K42/E161
Inactive tyrosine-protein kinase transmembrane receptor ROR1 (ROR1)
SC209
DBCO-nnAA-PEG13-AAN
ZA202500202A D04-Y180F404/K42/E161-LP21 [301]
D04-Y180F404/K42/E161
Inactive tyrosine-protein kinase transmembrane receptor ROR1 (ROR1)
SC209
DBCO-nnAA-PEG13-VKG
FS-1502
Undisclosed
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin F
Undisclosed
CBP-1008 [302]
Undisclosed
Folate receptor alpha (FOLR1); Transient receptor potential cation channel subfamily V member 6 (TRPV6)
Monomethyl auristatin E
Undisclosed
DXC004 [303]
Nimotuzumab derivative
Epidermal growth factor receptor (EGFR)
Tubulysin B analog
Undisclosed
ADC2122 [304]
Pertuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Duostatin 5
Pip-Val-Cit linker
CPO-102 [305]
Undisclosed
Claudin-18.2 (CLDN18.2)
Monomethyl auristatin E
Undisclosed
16A5-MCC-DM1 [306]
MBH-1309
Lymphocyte antigen 75 (LY75)
Mertansine DM1
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
RG-7600 [307]
Humanized IgG1 Anti-MSLN mAb h7D9.v3
Mesothelin (MSLN)
Monomethyl auristatin E
Protease-labile valine-citrulline linker
Trastuzumab botidotin [308]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Duostatin 5
K-lock-Val-Cit-PABC
HS630 [309]
Undisclosed
Receptor tyrosine-protein kinase erbB-2 (HER2)
Mertansine DM1
Undisclosed
BsADC [310]
anti PD-L1 with B7-H3 scFv
Programmed cell death 1 ligand 1 (PD-L1); CD276 antigen (CD276)
Monomethyl auristatin E
Undisclosed
pCAD x CDH17 bispecific MMAE ADC [311]
pCAD x CDH17 bispecific antibody bsAb 10
Cadherin-3 (CDH3); Cadherin-17 (CDH17)
Monomethyl auristatin E
Undisclosed
CD276 mAb-MMAF [312]
Hu276 mAb
CD276 antigen (CD276)
Monomethyl auristatin F
DBM linker
HER2 × HER3 BsADC [313]
23V
Receptor tyrosine-protein kinase erbB-2 (HER2); Receptor tyrosine-protein kinase erbB-3 (HER3)
Monomethyl auristatin E
Mc-Val-Cit-PABC
Anti-Her2_ (Q295)_AsnAsnPABC_MMAE [314]
Undisclosed
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
AsnAsnPABC
Anti-Her2_ (Q295)_AsnAlaPABC_MMAE [314]
Undisclosed
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
AsnAlaPABC
Antl-Her2_ (0295)_ValAlaPABC_MMAE [314]
Undisclosed
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
Mc-Val-Ala-PABC
Anti-Her2_AsnAsnPABC_MMAE [314]
Undisclosed
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
AsnAsnPABC
Anti-Her2_AsnAlaPABC_MMAE [314]
Undisclosed
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
AsnAlaPABC
Anti-Her2_ValCitPABC_MMAE [314]
Undisclosed
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
Mc-Val-Cit-PABC
Anti-Trop2_AsnAsnPABC_MMAE 7.6 [314]
Undisclosed
Tumor-associated calcium signal transducer 2 (TACSTD2)
Monomethyl auristatin E
AsnAsnPABC
Antl-Trop2_AsnAlaPABC_MMAE [314]
Undisclosed
Tumor-associated calcium signal transducer 2 (TACSTD2)
Monomethyl auristatin E
AsnAlaPABC
Antl-Trop2_ValAlaPABC_MMAE [314]
Undisclosed
Tumor-associated calcium signal transducer 2 (TACSTD2)
Monomethyl auristatin E
Mc-Val-Ala-PABC
Anti-Trop2_AsnAsnPABC_MMAE 4.5 [314]
Undisclosed
Tumor-associated calcium signal transducer 2 (TACSTD2)
Monomethyl auristatin E
AsnAsnPABC
Anti-Trop2_ValCitPABC_MMAE [314]
Undisclosed
Tumor-associated calcium signal transducer 2 (TACSTD2)
Monomethyl auristatin E
Mc-Val-Cit-PABC
Anti-0079b_AsnAsnPABC_MMAE [314]
Undisclosed
Undisclosed
Monomethyl auristatin E
AsnAsnPABC
Anti.CD79b_ValCitPABC_MMAE [314]
Undisclosed
B-cell antigen receptor complex-associated protein beta chain (CD79B)
Monomethyl auristatin E
Mc-Val-Cit-PABC
37917882 CD6-ADC [315]
UMCD6
T-cell differentiation antigen CD6 (CD6)
Monomethyl auristatin E
Mc-Val-Cit-PABC
Nonbinding control-ADC [315]
control mouse IgG
Undisclosed
Monomethyl auristatin E
Mc-Val-Cit-PABC
37235999 ADC 401-4 [316]
B7-H3 mAb 401
CD276 antigen (CD276)
Monomethyl auristatin E
Fmoc-Val-Cit-PAB-PNP
huNb26/Nb26-Nbh-MMAE [317]
huNb26/Nb26-Nbh
Nectin-4 (NECTIN4)
Monomethyl auristatin E
Mc-Val-Cit-PABC
37493255 7E7-DM4 ADC [318]
Undisclosed
Interleukin-3 receptor subunit alpha (IL3RA)
Mertansine DM4
Undisclosed
FG-ADC (DAR 4) [319]
Undisclosed
Undisclosed
Mertansine DM1
MA-FG-P12
FG-ADC (DAR 8) [319]
Undisclosed
Undisclosed
Mertansine DM1
MA-FG-P12
VAG-ADC (DAR 4) [319]
Undisclosed
Undisclosed
Mertansine DM1
MA-VAG-P12
VAG-ADC (DAR 8) [319]
Undisclosed
Undisclosed
Mertansine DM1
MA-VAG-P12
38139459 8D302-MMAE [320]
8D302
Sortilin (SORT1)
Monomethyl auristatin E
Mc-Val-Cit-PABC
Control to 8D302-MMAE [320]
Undisclosed
Undisclosed
Monomethyl auristatin E
Mc-Val-Cit-PABC
Mehozumab-DM1 [321]
Undisclosed
Basigin (BSG)
Mertansine DM1
Succinimidyl-4- (N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
GsADC 3b [322]
SAC 1
Tumor-associated calcium signal transducer 2 (TACSTD2)
Monomethyl auristatin E
Undisclosed
GsADC 5d [322]
SAC 1
Tumor-associated calcium signal transducer 2 (TACSTD2)
Monomethyl auristatin E
Undisclosed
KsADC 7a [322]
SAC 1
Tumor-associated calcium signal transducer 2 (TACSTD2)
Monomethyl auristatin E
Undisclosed
38981219 ADC 10a [322]
SAC 1
Tumor-associated calcium signal transducer 2 (TACSTD2)
Monomethyl auristatin E
Mc-Val-Cit-PABC
38981219 ADC 10b [322]
SAC 1
Tumor-associated calcium signal transducer 2 (TACSTD2)
Monomethyl auristatin E
Mc-Val-Cit-PABC
38981219 ADC 12a [322]
SAC 1
Tumor-associated calcium signal transducer 2 (TACSTD2)
Monomethyl auristatin E
NHS-VC-PAB
38981219 ADC 12b [322]
SAC 1
Tumor-associated calcium signal transducer 2 (TACSTD2)
Monomethyl auristatin E
NHS-VC-PAB
H1D8-DC [323]
H1D8
CD44 antigen (CD44)
Monomethyl auristatin E
Mc-Val-Cit-PABC
Actuximab-MMAE [324]
Actuximab
Carcinoembryonic antigen-related cell adhesion molecule 5 (CEACAM5)
Monomethyl auristatin E
Mc-Val-Cit-PABC
IgG-MMAE 8 [324]
Undisclosed
Undisclosed
Monomethyl auristatin E
Mc-Val-Cit-PABC
37146146 IC1-MMAE [325]
Chimeric ICAM1 Antibody (clone #R6.5)
Intercellular adhesion molecule 1 (ICAM1)
Monomethyl auristatin E
Mc-Val-Cit-PABC
37146146 IC1-MMAF [325]
Chimeric ICAM1 Antibody (clone #R6.5)
Intercellular adhesion molecule 1 (ICAM1)
Monomethyl auristatin F
Undisclosed
37146146 IC1-DM1 [325]
Chimeric ICAM1 Antibody (clone #R6.5)
Intercellular adhesion molecule 1 (ICAM1)
Mertansine DM1
Mal-EBE-Mal
37146146 IC1-DM4 [325]
Chimeric ICAM1 Antibody (clone #R6.5)
Intercellular adhesion molecule 1 (ICAM1)
Mertansine DM4
Mal-EBE-Mal
Control-MMAE-DAR3 [326]
Undisclosed
Undisclosed
Monomethyl auristatin E
Mc-Val-Cit-PABC
hu1084-MMAE-DAR3 [326]
Hu1084
Undisclosed
Monomethyl auristatin E
Mc-Val-Cit-PABC
hu1084-MMAE-DAR8 [326]
Hu1084
Undisclosed
Monomethyl auristatin E
Mc-Val-Cit-PABC
Trastuzumab-MMAU (DAR4) [327]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Glucuronyl-monomethyl-auristatin E (MMAU)
Val-Ser (beta-Glc) cleavable linker
Trastuzumab-MMAU (DAR8) [327]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Glucuronyl-monomethyl-auristatin E (MMAU)
Val-Ser (beta-Glc) cleavable linker
AGCM-22 [328]
Cetuximab
Epidermal growth factor receptor (EGFR)
Monomethyl auristatin E
Mc-Val-Ala-PABC
38850783 ADC 1 [329]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Mertansine DM1
Dimaleimide linker 1
38850783 ADC 2 [329]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Mertansine DM1
Dimaleimide linker 2
38850783 ADC 3 [329]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Mertansine DM1
Dimaleimide linker 3
38850783 ADC 4 [329]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Mertansine DM1
Dimaleimide linker 4
38850783 ADC 5 [329]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Mertansine DM1
Dimaleimide linker 5
RS7-DL 1 [330]
hRS7
Tumor-associated calcium signal transducer 2 (TACSTD2)
Monomethyl auristatin E
Mc-Val-Cit-PABC
RS7-DL 2 [330]
hRS7
Tumor-associated calcium signal transducer 2 (TACSTD2)
Monomethyl auristatin E
Mal-PEG4-Val-Cit-PABC
RS7-DL 3 [330]
hRS7
Tumor-associated calcium signal transducer 2 (TACSTD2)
Monomethyl auristatin E
Mal-PEG8-Val-Cit-PAB
RS7-DL 4 [330]
hRS7
Tumor-associated calcium signal transducer 2 (TACSTD2)
Monomethyl auristatin E
Mal-PEG24-Val-Cit-PAB
RS7-DL 5 [330]
hRS7
Tumor-associated calcium signal transducer 2 (TACSTD2)
Monomethyl auristatin E
Mal-PEG8-Val-Cit-PEG8-PAB
RS7-DL 6 [330]
hRS7
Tumor-associated calcium signal transducer 2 (TACSTD2)
Monomethyl auristatin E
Mal-PEG4-Lys (PEG24)-Cit-PAB
RS7-DL 7 [330]
hRS7
Tumor-associated calcium signal transducer 2 (TACSTD2)
Monomethyl auristatin E
Mal-PEG8-Val-Lys (PEG8)-Cit-PAB
RS7-DL 8 [330]
hRS7
Tumor-associated calcium signal transducer 2 (TACSTD2)
Monomethyl auristatin E
Mal-PEG4-Val-Lys (PEG12)-Cit-PAB
RS7-DL 9 [330]
hRS7
Tumor-associated calcium signal transducer 2 (TACSTD2)
Monomethyl auristatin E
Mal-PEG4-Val-Lys (PEG16)-Cit-PAB
RS7-DL 10 [330]
hRS7
Tumor-associated calcium signal transducer 2 (TACSTD2)
Monomethyl auristatin E
Mal-PEG4-Val-Lys (PEG24)-Cit-PAB
RS7-DL 11 [330]
hRS7
Tumor-associated calcium signal transducer 2 (TACSTD2)
Monomethyl auristatin E
Mal-Val-Lys (PEG24)-Cit-PAB
RS7-DL 12 [330]
hRS7
Tumor-associated calcium signal transducer 2 (TACSTD2)
Monomethyl auristatin E
Mal-Val-Lys-PAB
RS7-DL 13 [330]
hRS7
Tumor-associated calcium signal transducer 2 (TACSTD2)
Monomethyl auristatin E
Mal-PEG4-Lys (PEG24)-Cit-PAB
RS7-DL 14 [330]
hRS7
Tumor-associated calcium signal transducer 2 (TACSTD2)
Monomethyl auristatin E
Mal-Gly (glucose)-Val-Cit-PAB
RS7-DL 15 [330]
hRS7
Tumor-associated calcium signal transducer 2 (TACSTD2)
Monomethyl auristatin E
Mal-Val-Lys (Ser-PEG4-glucose)-PAB
RS7-DL 16 [330]
hRS7
Tumor-associated calcium signal transducer 2 (TACSTD2)
Monomethyl auristatin E
Mal-Val-Lys (Ser-PEG4-glucose)-PAB
Anti-CD276 mAb-MMAF [331]
Anti-CD276 mAb
CD276 antigen (CD276)
Monomethyl auristatin F
Undisclosed
39410752 ADC (5) [332]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
Mal-Exo-EVC
39410752 ADC (6) [332]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
Mal-Exo-EEVC
39410752 ADC (8) [332]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
Mal-Exo-EEVC
39410752 ADC (10) [332]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
Mc-Val-Cit-PABC
39410752 ADC (11) [332]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
Mc-Val-Cit-PABC
39410752 ADC (12) [332]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
Mc-EVC-PAB
37834445 15cl12 L328C MMAE [333]
15cl12 L328C
Immunoglobulin E (IgE)
Monomethyl auristatin E
Mc-Val-Cit-PABC
37492000 ADC 6a (4h) [334]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
TetraDVP based linker 1a
37492000 ADC 6b (4h) [334]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
TetraDVP based linker 1b
37492000 ADC 6c (4h) [334]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
TetraDVP based linker 1c
37492000 ADC 6d (4h) [334]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
TetraDVP based linker 1d
37492000 ADC 7a (4h) [334]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
TetraDVP based linker 2a
37492000 ADC 7b (4h) [334]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
TetraDVP based linker 2b
37492000 ADC 7c (4h) [334]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
TetraDVP based linker 2c
37492000 ADC 7d (4h) [334]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
TetraDVP based linker 2d
37492000 ADC 6a (24h) [334]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
TetraDVP based linker 1a
37492000 ADC 6b (24h) [334]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
TetraDVP based linker 1b
37492000 ADC 6c (24h) [334]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
TetraDVP based linker 1c
37492000 ADC 6d (24h) [334]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
TetraDVP based linker 1d
37492000 ADC 7a (24h) [334]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
TetraDVP based linker 2a
37492000 ADC 7b (24h) [334]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
TetraDVP based linker 2b
37492000 ADC 7c (24h) [334]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
TetraDVP based linker 2c
37492000 ADC 7d (24h) [334]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
TetraDVP based linker 2d
T4H11-DM4 [335]
T4H11
Epithelial discoidin domain-containing receptor 1 (DDR1)
Mertansine DM4
N-succinimidyl 3- (2-pyridyldithio) propionate (SPDP)
hSD5-vedotin [336]
hSD5
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
Mc-Val-Cit-PABC
IgG-vedotin [336]
Undisclosed
Undisclosed
Monomethyl auristatin E
Mc-Val-Cit-PABC
39143910 ADC 40 [337]
Cetuximab
Epidermal growth factor receptor (EGFR)
Monomethyl auristatin E
1- (4,4-dimethyl-2,6-dioxocyclohexylidene)ethyl (Dde) based linker
S1 Trastuzumab glycovariants ADC [338]
S1 Trastuzumab glycovariants
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
DBCO-PEG4-Val-Cit
S4 Trastuzumab glycovariants ADC [338]
S4 Trastuzumab glycovariants
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
DBCO-PEG4-Val-Cit
S6 Trastuzumab glycovariants ADC [338]
S6 Trastuzumab glycovariants
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
DBCO-PEG4-Val-Cit
F12-MMAE [339]
F12
Prostate stem cell antigen (PSCA)
Monomethyl auristatin E
NHS-VC-PAB
Ab1-MMAE [339]
Ab1
Nectin-4 (NECTIN4)
Monomethyl auristatin E
NHS-VC-PAB
37573404 CD6-ADC [340]
UMCD6
T-cell differentiation antigen CD6 (CD6)
Monomethyl auristatin E
Mc-Val-Cit-PABC
Non-binding IgG -ADC [340]
Control mouse IgG
Undisclosed
Monomethyl auristatin E
Mc-Val-Cit-PABC
humanized CD6-ADC [340]
Humanized UMCD6
T-cell differentiation antigen CD6 (CD6)
Monomethyl auristatin E
Mc-Val-Cit-PABC
algM ADC [341]
Masked chicken-derived anti-IgM (aIgM) antibody
Undisclosed
Monomethyl auristatin E
DBCO-PEG4-Val-Cit-PABC
Masked Protease-activated CH2-aIgM ADC [341]
Protease-activated chicken-derived anti-IgM (aIgM) antibody
Undisclosed
Monomethyl auristatin E
DBCO-PEG4-Val-Cit-PABC
Nectin-4-MMAE [342]
MW282 mAb
Nectin-4 (NECTIN4)
Monomethyl auristatin E
IDconnect linker
36924655 ADC 28 [343]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
Undisclosed
36924655 ADC 29 [343]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
Undisclosed
36924655 ADC 30 [343]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
Undisclosed
36924655 ADC 31 [343]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
Undisclosed
36924655 ADC 5 [343]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
Undisclosed
36924655 ADC 6 [343]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
Undisclosed
36924655 ADC 7 [343]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
Undisclosed
36924655 ADC 8 [343]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
Undisclosed
36924655 ADC 9 [343]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
Undisclosed
36924655 ADC 10 [343]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
Undisclosed
36924655 ADC 11 [343]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
Undisclosed
36924655 ADC 12 [343]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
Undisclosed
36924655 ADC 13 [343]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
Undisclosed
36924655 ADC 14 [343]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
Undisclosed
36924655 ADC 15 [343]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
Undisclosed
36924655 ADC 32 [343]
Bevacizumab
Vascular endothelial growth factor A (VEGFA)
Monomethyl auristatin E
Undisclosed
36924655 ADC 33 [343]
Cetuximab
Epidermal growth factor receptor (EGFR)
Monomethyl auristatin E
Undisclosed
B2C4-MMAE [344]
B2C4
Epidermal growth factor receptor (EGFR); Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
Mc-Val-Cit-PABC
B2-MMAE [344]
B2
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
Mc-Val-Cit-PABC
C4-MMAE [344]
C4
Epidermal growth factor receptor (EGFR)
Monomethyl auristatin E
Mc-Val-Cit-PABC
Trastuzumab-LplA-MMAE [345]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
DBCO-Val-Cit-PABC
Rituximab-LplA-MMAE [345]
Rituximab
B-lymphocyte antigen CD20 (MS4A1)
Monomethyl auristatin E
DBCO-Val-Cit-PABC
B9-MMAE [346]
B9
Carcinoembryonic antigen-related cell adhesion molecule 5 (CEACAM5)
Monomethyl auristatin E
Mc-Val-Cit-PABC
alpha-cMET FDC-MMAE_C [347]
cMET A1-8 IgG Fab
Hepatocyte growth factor receptor (MET)
Monomethyl auristatin E
Undisclosed
alpha-RSV FDC-MMAE_C [347]
anti-RSV IgG Fab
Respiratory syncytial virus (RSV)
Monomethyl auristatin E
Undisclosed
hIMB1636-MMAE [348]
hIMB1636
Tumor-associated calcium signal transducer 2 (TACSTD2)
Monomethyl auristatin E
Mc-Val-Cit-PABC
CA1-vedotin [349]
CA1
Undisclosed
Monomethyl auristatin E
Mc-Val-Cit-PABC
Anti-CD79b-RKAA-MMAE ADC [350]
Undisclosed
B-cell antigen receptor complex-associated protein beta chain (CD79B)
Monomethyl auristatin E
RKAA-PABC
LA-057-MMAE [351]
LA-057
Leukocyte-associated immunoglobulin-like receptor 1 (LAIR1)
Monomethyl auristatin E
Mc-Val-Cit-PABC
38679234 ADC1-MMAE [352]
Undisclosed
Undisclosed
Monomethyl auristatin E
Undisclosed
38679234 ADC1-DM1 [352]
Undisclosed
Undisclosed
Mertansine DM1
Succinimidyl-4- (N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
Trastuzumab- (VC-PABC-MMAE)2 [353]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
Undisclosed
HAV ADC [354]
HAV
Hepatocyte growth factor receptor (MET)
Monomethyl auristatin E
Undisclosed
LAV ADC [354]
LAV
Hepatocyte growth factor receptor (MET)
Monomethyl auristatin E
Undisclosed
Tras (C8)-MMAE [355]
Trastuzumab (C8)
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
Mc-Val-Cit-PABC
aCSPG4 (scFv)-SNAP-AURIF [356]
aCSPG4 (scFv)-SNAP
Chondroitin sulfate proteoglycan 4 (CSPG4)
Monomethyl auristatin F
Undisclosed
Trastuzumab-DM1 (K248) [357]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Mertansine DM1
Undisclosed
Trastuzumab-MMAE (K248) [357]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
Undisclosed
Trastuzumab-MMAE (K288) [357]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
Undisclosed
Rituximab-DM1 (K248) [357]
Rituximab
B-lymphocyte antigen CD20 (MS4A1)
Mertansine DM1
Undisclosed
Rituximab-MMAE (K248) [357]
Rituximab
B-lymphocyte antigen CD20 (MS4A1)
Monomethyl auristatin E
Undisclosed
CD79b-MMAE [358]
Undisclosed
B-cell antigen receptor complex-associated protein beta chain (CD79B)
Monomethyl auristatin E
Mc-Val-Cit-PABC
39837982 ADC PCMdt-MMAE [359]
PCMbs-MR
Hepatocyte growth factor receptor (MET); Macrophage-stimulating protein receptor (MST1R)
Monomethyl auristatin E
Mc-Val-Cit-PABC
CD22 Nanobody DM1 [360]
CD22 Nanobody
B-cell receptor CD22 (CD22)
Mertansine DM1
Succinimidyl-4- (N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
38888299 ADC 1 [361]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
Tuneable thiol exchange linker 1
38888299 ADC 2 [361]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
Tuneable thiol exchange linker 2
38888299 ADC 3 [361]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
Tuneable thiol exchange linker 3
Trastu-AzaNIRII-MMAE [362]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
azaNIRII-BCN-PEG4-VAC-PAB
Site-sepcific ADC 1 [363]
Zilovertamab
Inactive tyrosine-protein kinase transmembrane receptor ROR1 (ROR1)
Monomethyl auristatin E
TE-VC-PAB
Site-sepcific ADC 2 [363]
Zilovertamab
Inactive tyrosine-protein kinase transmembrane receptor ROR1 (ROR1)
Monomethyl auristatin E
TE-VC-PAB
Site-sepcific ADC 3 [363]
Zilovertamab
Inactive tyrosine-protein kinase transmembrane receptor ROR1 (ROR1)
Monomethyl auristatin E
TE-VC-PAB
Site-sepcific ADC 4 [363]
Zilovertamab
Inactive tyrosine-protein kinase transmembrane receptor ROR1 (ROR1)
Monomethyl auristatin E
TE-VC-PAB
Site-sepcific ADC 5 [363]
Zilovertamab
Inactive tyrosine-protein kinase transmembrane receptor ROR1 (ROR1)
Monomethyl auristatin E
TE-VC-PAB
Site-sepcific ADC 6 [363]
Zilovertamab
Inactive tyrosine-protein kinase transmembrane receptor ROR1 (ROR1)
Monomethyl auristatin E
TE-VC-PAB
Site-sepcific ADC 7 [363]
Zilovertamab
Inactive tyrosine-protein kinase transmembrane receptor ROR1 (ROR1)
Monomethyl auristatin E
TE-VC-PAB
Site-sepcific ADC 8 [363]
Zilovertamab
Inactive tyrosine-protein kinase transmembrane receptor ROR1 (ROR1)
Monomethyl auristatin E
TE-VC-PAB
Site-sepcific ADC 9 [363]
Zilovertamab
Inactive tyrosine-protein kinase transmembrane receptor ROR1 (ROR1)
Monomethyl auristatin E
TE-VC-PAB
Site-sepcific ADC 10 [363]
Zilovertamab
Inactive tyrosine-protein kinase transmembrane receptor ROR1 (ROR1)
Monomethyl auristatin E
TE-VC-PAB
Site-sepcific ADC 11 [363]
Zilovertamab
Inactive tyrosine-protein kinase transmembrane receptor ROR1 (ROR1)
Monomethyl auristatin E
TE-VC-PAB
Site-sepcific ADC 12 [363]
Zilovertamab
Inactive tyrosine-protein kinase transmembrane receptor ROR1 (ROR1)
Monomethyl auristatin E
TE-VC-PAB
40151029 ADC 1 [363]
Sacituzumab
Tumor-associated calcium signal transducer 2 (TACSTD2)
Monomethyl auristatin E
TE-VC-PAB
40151029 ADC 2 [363]
Sacituzumab
Tumor-associated calcium signal transducer 2 (TACSTD2)
Monomethyl auristatin E
TE-VC-PAB
Trz-LC:p67-MMAE [364]
Trz-LC:p67
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
Undisclosed
Trz-HC:p67-MMAE [364]
Trz-HC:p67
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
Undisclosed
40187444 7DC2-DM1 [365]
7DC2
Leukocyte surface antigen CD47 (CD47)
Mertansine DM1
Succinimidyl-4- (N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
40187444 7DC4-DM1 [365]
7DC4
Leukocyte surface antigen CD47 (CD47)
Mertansine DM1
Succinimidyl-4- (N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
39914224 Ate-36 [366]
Atezolizumab
Programmed cell death 1 ligand 1 (PD-L1)
Monomethyl auristatin E
Phenoxy silyl linker 36
39914224 Ate-37 [366]
Atezolizumab
Programmed cell death 1 ligand 1 (PD-L1)
Monomethyl auristatin E
Phenoxy silyl linker 37
39914224 Ate-38 [366]
Atezolizumab
Programmed cell death 1 ligand 1 (PD-L1)
Monomethyl auristatin E
Phenoxy silyl linker 38
39914224 Ate-39 [366]
Atezolizumab
Programmed cell death 1 ligand 1 (PD-L1)
Monomethyl auristatin E
Phenoxy silyl linker 39
39757732 ADC1 [367]
Ab-2
Undisclosed
Monomethyl auristatin E
D1 Linker
39757732 ADC3 [367]
Ab-2
Undisclosed
Monomethyl auristatin E
D3 Linker
Ptz-SA vedotin [368]
Ptz-SA
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
Mc-Val-Cit-PABC
40410803 16B10-DM1 [369]
16B10
Transforming growth factor alpha (TGFA)
Mertansine DM1
Succinimidyl-4- (N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
40410803 16B10-MMAF [369]
16B10
Transforming growth factor alpha (TGFA)
Monomethyl auristatin F
Mc-Val-Cit-PABC
40410803 5F1-DM1 [369]
5F1
Transforming growth factor alpha (TGFA)
Mertansine DM1
Succinimidyl-4- (N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
40410803 5F1-MMAF [369]
5F1
Transforming growth factor alpha (TGFA)
Monomethyl auristatin F
Mc-Val-Cit-PABC
Anti-CD64 (scFv)-SNAP-Auristatin F [370]
H22 (scFv)-SNAP
High affinity immunoglobulin gamma Fc receptor I (Fcgr1)
Monomethyl auristatin F
Undisclosed
alphaTROP2-MMAE [371]
Undisclosed
Tumor-associated calcium signal transducer 2 (TACSTD2)
Monomethyl auristatin E
Undisclosed
Mouse IgG2a-Val-Cit-Pab-MMAE [372]
Mouse IgG2a
Undisclosed
Monomethyl auristatin E
Undisclosed
Mouse IgG2a-PEG8-MMAE [372]
Mouse IgG2a
Undisclosed
Monomethyl auristatin E
Undisclosed
hIgG1-MMAE (gylcan conjugation) [372]
hIgG1
Undisclosed
Monomethyl auristatin E
Undisclosed
Isotype-MMAE (gylcan conjugation) [372]
Undisclosed
Undisclosed
Monomethyl auristatin E
Undisclosed
hIgG1-MMAE (Lysine conjugation) [372]
hIgG1
Undisclosed
Monomethyl auristatin E
Undisclosed
Isotype-MMAE (Lysine conjugation) [372]
Undisclosed
Undisclosed
Monomethyl auristatin E
Undisclosed
Ipi-DM1 38127423 [373]
Ipilimumab
Cytotoxic T-lymphocyte protein 4 (CTLA4)
Mertansine DM1
Undisclosed
hIgGFc-DM1 (38127423) [373]
Undisclosed
Undisclosed
Mertansine DM1
Undisclosed
39812376 84-MMAE [374]
#84.7
Carcinoembryonic antigen-related cell adhesion molecule 6 (CEACAM6)
Monomethyl auristatin E
Undisclosed
anti CAD-ADC [375]
h3E1
Cell adhesion molecule 1 (CADM1)
Monomethyl auristatin E
Mc-Val-Cit-PABC
OncoFAP-GlyPro-MMAE [376]
OncoFAP
Prolyl endopeptidase FAP (FAP)
Monomethyl auristatin E
Maleimido Caproyl-GlyPro-PAB linker
HuNb (TROP2-HSA)-MMAE [377]
HuNb (TROP2-HSA)
Tumor-associated calcium signal transducer 2 (TACSTD2)
Monomethyl auristatin E
Mc-Val-Cit-PABC
39870768 20D9h3-MMAF [378]
20D9h3
Receptor-type tyrosine-protein kinase FLT3 (FLT3)
Monomethyl auristatin F
Undisclosed
39860260 2Rs15d-H3KH6-MMAE [379]
2Rs15d
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
DBCO-PEG4-Val-Cit-PABC
Tras-VC-MMAE [380]
Tras-N3
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
Mc-Val-Cit-PABC
anti TRBC1-MMAE [381]
Undisclosed
T cell receptor beta-chain constant region 1 (TRBC1)
Monomethyl auristatin E
Mc-Val-Cit-PABC
Tra-CAST-MMAE [382]
Tra-CAST
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
Styrylboronic acid-Val-Cit-PAB
AXL02-MMAE [383]
AXL02
Tyrosine-protein kinase receptor UFO (AXL)
Monomethyl auristatin E
Undisclosed
AXL02-vc-MMAE [383]
AXL02
Tyrosine-protein kinase receptor UFO (AXL)
Monomethyl auristatin E
Mc-Val-Cit-PABC
huB12-MMAE [384]
huB12
Prolyl endopeptidase FAP (FAP)
Monomethyl auristatin E
Mc-Val-Cit-PABC
huB12-MMAF [384]
huB12
Prolyl endopeptidase FAP (FAP)
Monomethyl auristatin F
Mc-Val-Cit-PABC
huB12-DM1 [384]
huB12
Prolyl endopeptidase FAP (FAP)
Mertansine DM1
Mc-Val-Cit-PABC
h3E1-MMAE [385]
h3E1
Cell adhesion molecule 1 (CADM1)
Monomethyl auristatin E
Mc-Val-Cit-PABC
hIgG-MMAE [385]
Undisclosed
Undisclosed
Monomethyl auristatin E
Mc-Val-Cit-PABC
GLK-33 [386]
Lintuzumab
Myeloid cell surface antigen CD33 (CD33)
Glucuronyl-monomethyl-auristatin E (MMAU)
Undisclosed
chMC-813-70-VC-PAB-MMAE [387]
chMC-813-70
Stage-specific embryonic antigen-4 (SSEA4)
Monomethyl auristatin E
DBCO-PEG4-Val-Cit-PABC
chMC-813-70-PAB-MMAE [387]
chMC-813-70
Stage-specific embryonic antigen-4 (SSEA4)
Monomethyl auristatin E
DBCO-PEG4-PAB
HC-A118C-1a [388]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
Undisclosed
HC-A118C-1b [388]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
Undisclosed
HC-A118C-2 [388]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
Undisclosed
HC-A118C-3 [388]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
Undisclosed
HC-A118C-4 [388]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
Undisclosed
HC-A140C-1a [388]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
Undisclosed
HC-A140C-1b [388]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
Undisclosed
HC-A140C-2 [388]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
Undisclosed
HC-A140C-3 [388]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
Undisclosed
HC-A140C-4 [388]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
Undisclosed
HC-E258C-1a [388]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
Undisclosed
HC-E258C-1b [388]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
Undisclosed
HC-E258C-2 [388]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
Undisclosed
HC-E258C-3 [388]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
Undisclosed
HC-E258C-4 [388]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
Undisclosed
HC-S400C-1a [388]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
Undisclosed
HC-S400C-1b [388]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
Undisclosed
HC-S400C-2 [388]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
Undisclosed
HC-S400C-3 [388]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
Undisclosed
HC-S400C-4 [388]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
Undisclosed
LC-K149C-1a [388]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
Undisclosed
LC-K149C-1b [388]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
Undisclosed
LC-K149C-2 [388]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
Undisclosed
LC-K149C-3 [388]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
Undisclosed
LC-K149C-4 [388]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
Undisclosed
LC-V205C-1a [388]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
Undisclosed
LC-V205C-1b [388]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
Undisclosed
LC-V205C-2 [388]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
Undisclosed
LC-V205C-3 [388]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
Undisclosed
LC-V205C-4 [388]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
Undisclosed
38501590 Anti-HER2 ARC-FDC (1) [389]
Trastuzumab-Fab-cd38
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin F
2'-Cl-araNAD linker
38501590 Anti-HER2 ARC-FDC (2) [389]
Trastuzumab-Fab-cd38
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin F
2'-Cl-araNAD linker
Positively Charged ADC [390]
Trastuzumab (Positively Charged)
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
Mc-Val-Cit-PABC
WT ADC [390]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
Mc-Val-Cit-PABC
CD98hc-ADC [391]
Undisclosed
Solute carrier family 3 member 2 (SLC3A2)
Mertansine DM1
Undisclosed
38703658 19G4-MMAE [392]
19G4
Solute carrier family 3 member 2 (SLC3A2)
Monomethyl auristatin E
Undisclosed
aTCRA6 DAR2 [393]
aTCRA6S1
Transcriptional regulatory protein TcrA (TCRA6)
Monomethyl auristatin E
DBCO-PEG4-Val-Cit-PABC
aTCRA6 DAR2-8 [393]
aTCRA6S1
Transcriptional regulatory protein TcrA (TCRA6)
Monomethyl auristatin E
DBCO-PEG4-Val-Cit-PABC
Enfortumab-MMAE [394]
Enfortumab
Nectin-4 (NECTIN4)
Monomethyl auristatin E
Undisclosed
37520726 I1-MMAE [395]
Undisclosed
Intercellular adhesion molecule 1 (ICAM1)
Monomethyl auristatin E
Mc-Val-Cit-PABC
n501-MMAE [396]
n501
Trophoblast glycoprotein (TPBG)
Monomethyl auristatin E
Mc-Val-Cit-PABC
n501-alphaHSA-MMAE [396]
n501-alphaHSA
Trophoblast glycoprotein (TPBG)
Monomethyl auristatin E
Mc-Val-Cit-PABC
anti-TAG-72 ADC [397]
Undisclosed
Tumor-associated glycoprotein 72 (TAG-72)
Monomethyl auristatin E
Undisclosed
Trastuzumab-Qtag2-MMAE [398]
Trastuzumab-Qtag2
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
PEG4-VC-PAB
Trastuzumabk453del-Qtag2-MMAE [398]
Trastuzumabk453del-Qtag2
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
PEG4-VC-PAB
Trastuzumab-Qtag2-DM1 [398]
Trastuzumab-Qtag2
Receptor tyrosine-protein kinase erbB-2 (HER2)
Mertansine DM1
PEG4-SMCC
Ipi-DM1 36909522 [399]
Ipilimumab
Cytotoxic T-lymphocyte protein 4 (CTLA4)
Mertansine DM1
Undisclosed
hIgGFc-DM1 (36909522) [399]
Undisclosed
Undisclosed
Mertansine DM1
Undisclosed
scFv-PEG4-DM1 [400]
Undisclosed
Undisclosed
Mertansine DM1
Undisclosed
scFv-PEG4-DM4 [400]
Undisclosed
Undisclosed
Mertansine DM4
Undisclosed
h3E1-MMAE ADC [401]
h3E1
Cell adhesion molecule 1 (CADM1)
Monomethyl auristatin E
Mc-Val-Cit-PABC
alphaCLDN18.2-MMAE [402]
Undisclosed
Claudin-18.2 (CLDN18.2)
Monomethyl auristatin E
Undisclosed
XiRB49 MMAE [403]
xiRB49
Endothelin-1 (EDN1)
Monomethyl auristatin E
Mc-Val-Cit-PABC
40287441 3D1 MMAE [404]
MUC1 3D1
Mucin-1 (MUC1)
Monomethyl auristatin E
Mc-Val-Cit-PABC
PF-08046032 [405]
A detuned-affinity anti-CD25 mAb
Interleukin-2 receptor subunit alpha (IL2RA)
Monomethyl auristatin E
Mc-Val-Cit-PABC
YB-800 MMAF [406]
YB-800
Neuronal pentraxin receptor (NPTXR)
Monomethyl auristatin F
Undisclosed
TDC MMAE [407]
Undisclosed
Undisclosed
Monomethyl auristatin E
Mc-Val-Cit-PABC
CD318-MMAE [408]
Undisclosed
CUB domain-containing protein 1 (CDCP1)
Monomethyl auristatin E
Undisclosed
TGW101 [409]
Anti-TAG-72 antibody
Tumor-associated glycoprotein 72 (TAG-72)
Monomethyl auristatin E
A cleavable linker
Non-pH-B7-H3 Ab-MMAE [410]
Non-pH-B7-H3 Ab
CD276 antigen (CD276)
Monomethyl auristatin E
Mc-Val-Cit-PABC
pH-B7-H3 Ab-MMAE [410]
pH-B7-H3 Ab
CD276 antigen (CD276)
Monomethyl auristatin E
Mc-Val-Cit-PABC
IDP-001 [411]
Undisclosed
CUB domain-containing protein 1 (CDCP1); Epidermal growth factor receptor (EGFR)
Monomethyl auristatin E
Undisclosed
SDV2102 [412]
D10
Glutamate carboxypeptidase 2 (FOLH1)
Monomethyl auristatin E
Undisclosed
AT2604 [413]
Undisclosed
Alkaline phosphatase, germ cell type (ALPG); Alkaline phosphatase, placental type (ALPP)
Monomethyl auristatin E
Undisclosed
BSI-721 [414]
Fully humanized anti-CDH17 monoclonal antibody
Cadherin-17 (CDH17)
Monomethyl auristatin E
Undisclosed
PB-MMAE-2 [415]
PB-223
Truncated Core-2 O-glycans
Monomethyl auristatin E
Mc-Val-Cit-PABC
PB-MMAE-5 [415]
PB-223
Truncated Core-2 O-glycans
Monomethyl auristatin E
Mc-Val-Cit-PABC
PB-MMAE-6 [415]
PB-223
Truncated Core-2 O-glycans
Monomethyl auristatin E
Mc-Val-Cit-PABC
BB-205 [416]
bispecific anti-c-Met/EGFR antibody
Receptor tyrosine-protein kinase erbB-2 (HER2); Hepatocyte growth factor receptor (MET)
Monomethyl auristatin E
Mc-Val-Cit-PABC
GPC1-ADC [417]
humanized anti-GPC1 monoclonal antibody
Glypican-1 (GPC1)
Monomethyl auristatin E
Undisclosed
PLB-002 [418]
PLB-002-ab7
Claudin-6 (CLDN6)
Eribulin
A cleavable linker
Anti-hEGFR (IgG4)-ABNO-DM-1: E4-AD [419]
anti-EGFR IgG4 antibody
Epidermal growth factor receptor (EGFR)
Mertansine DM1
ABNO Linker
PF-08046031 [420]
HL49
Melanotransferrin (MELTF)
Monomethyl auristatin E
Mc-Val-Cit-PABC
BR111 [421]
Anti-ROR1 mAb
Inactive tyrosine-protein kinase transmembrane receptor ROR1 (ROR1)
Eribulin
Undisclosed
3A11-MMAE [422]
3A11
Fibroblast growth factor receptor 4 (FGFR4)
Monomethyl auristatin E
Mc-Val-Cit-PABC
ADRX-0134 [423]
Undisclosed
Sodium-dependent phosphate transport protein 2B (SLC34A2)
AP052
Undisclosed
KY-0301
EGFR/c-Met bispecific nanobody
Hepatocyte growth factor receptor (MET); Epidermal growth factor receptor (EGFR)
Monomethyl auristatin E
A cleavable linker
CN119343152A 1C1-Example 1 [424]
1C1
Ephrin type-A receptor 2 (EPHA2)
CN119343152A 1C1-Example1 Payload
CN119343152A 1C1-Example1 Linker
CN119343152A 1C1-Example 2 [424]
1C1
Ephrin type-A receptor 2 (EPHA2)
CN119343152A 1C1-Example1 Payload
CN119343152A 1C1-Example2 Linker
Trastuzumab-Example 1 [424]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
CN119343152A 1C1-Example1 Payload
CN119343152A 1C1-Example1 Linker
Trastuzumab-Example 2 [424]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
CN119343152A 1C1-Example1 Payload
CN119343152A 1C1-Example2 Linker
NOV169N31Q-Example 1 [424]
NOV169N31Q
Cadherin-3 (CDH3)
CN119343152A 1C1-Example1 Payload
CN119343152A 1C1-Example1 Linker
NOV169N31Q-Example 2 [424]
NOV169N31Q
Cadherin-3 (CDH3)
CN119343152A 1C1-Example1 Payload
CN119343152A 1C1-Example2 Linker
Trastuzumab-Example 5 [424]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
CN119343152A Trastuzumab-Example5 Payload
CN119343152A 1C1-Example1 Linker
BR112024020733A2ADC1 [425]
2G10-5
Tumor-associated calcium signal transducer 2 (TACSTD2)
Monomethyl auristatin E
BR112024020733A2 ADC1 Linker
FS002-A1-vc-MMAE [426]
FS002-A1
Integrin alpha 2 (ITGA2)
Monomethyl auristatin E
Undisclosed
FS002-A15-vc-MMAE [426]
FS002-A15
Integrin alpha 2 (ITGA2)
Monomethyl auristatin E
Undisclosed
FS002-A36-vc-MMAE [426]
FS002-A36
Integrin alpha 2 (ITGA2)
Monomethyl auristatin E
Undisclosed
Vatelizumab-vc-MMAE [426]
Vatelizumab
Integrin alpha 2 (ITGA2)
Monomethyl auristatin E
Undisclosed
CN110997009BADC#42 [427]
C38A2/C38D8
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 (CD38)
CN110997009B ADC#42 Payload
CN110997009B ADC#42 Linker
CN110997009BADC#43 [427]
C38A2/C38D8
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 (CD38)
CN110997009B ADC#43 Payload
CN110997009B ADC#42 Linker
CN110997009BADC#44 [427]
C38A2/C38D8
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 (CD38)
Duo5
CN110997009B ADC#40 Linker
CN110997009BADC#45 [427]
C38A2/C38D8
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 (CD38)
Duo5
CN110997009B ADC#45 Linker
CN110997009BADC#46 [427]
C38A2/C38D8
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 (CD38)
Duo5
CN110997009B ADC#46 Linker
HIS092-vc-MMAE [428]
HIS029
CD44 antigen (CD44)
Monomethyl auristatin E
Mc-Val-Cit-PABC
MORAb-003 ADC5 [429]
MORAb-003
Folate receptor alpha (FOLR1)
Eribulin
VCP linker
MORAb-003 ADC8 [429]
MORAb-003
Folate receptor alpha (FOLR1)
Mertansine DM1
6-Maleimidocaproic acid
MORAb-003 ADC9 [429]
MORAb-003
Folate receptor alpha (FOLR1)
Monomethyl auristatin E
Maleimidyl- (CH2)5-Val-Cit-pAB linker
MORAb-003 ADC10 [429]
MORAb-003
Folate receptor alpha (FOLR1)
Auristatin F
NHS-PEG2 linker
MORAb-003 ADC11 [429]
MORAb-003
Folate receptor alpha (FOLR1)
Mertansine DM1
Succinimidyl-4- (N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
MORAb-003 ADC13 [429]
MORAb-003
Folate receptor alpha (FOLR1)
Dolicatatin 5
Asn-Ala linker
MORAb-003 ADC33 [430]
MORAb-003
Folate receptor alpha (FOLR1)
Dolicatatin 5
PEG-pAB linker
NY920-DAPA-VC-MMAE [431]
NY920-DAPA
CD48 antigen (CD48)
Monomethyl auristatin E
Mc-Val-Cit-PABC
NY920-CysMab-VC-MMAE [431]
NY920-CysMab
CD48 antigen (CD48)
Monomethyl auristatin E
Mc-Val-Cit-PABC
NY938-DAPA-VC-MMAE [431]
NY938-DAPA
CD48 antigen (CD48)
Monomethyl auristatin E
Mc-Val-Cit-PABC
NY938-CysMab-VC-MMAE [431]
NY938-CysMab
CD48 antigen (CD48)
Monomethyl auristatin E
Mc-Val-Cit-PABC
CN119019562A ADC1 S-49-8 [432]
S-49-8
Undisclosed
Monomethyl auristatin E
Mc-Val-Cit-PABC
CN119019562A ADC1 S-60-6 [432]
S-60-6
Undisclosed
Monomethyl auristatin E
Mc-Val-Cit-PABC
CN119019562A ADC2 S-49-8 [432]
S-49-8
Undisclosed
Monomethyl auristatin E
Mc-Val-Cit-PABC
CN119019562A ADC2 S-60-6 [432]
S-60-6
Undisclosed
Monomethyl auristatin E
Mc-Val-Cit-PABC
CN119019562A ADC3 S-49-8 [432]
S-49-8
Undisclosed
Monomethyl auristatin E
Mc-Val-Cit-PABC
CN119019562A ADC3 S-60-6 [432]
S-60-6
Undisclosed
Monomethyl auristatin E
Mc-Val-Cit-PABC
CN119019562A ADC4 S-49-8 [432]
S-49-8
Undisclosed
Monomethyl auristatin E
Mc-Val-Cit-PABC
CN119019562A ADC4 S-60-6 [432]
S-60-6
Undisclosed
Monomethyl auristatin E
Mc-Val-Cit-PABC
EP4461318A2 anti-PSMA ADC1 [433]
Humanized Anti-PSMA Antibody Variant 1
Glutamate carboxypeptidase 2 (FOLH1)
Monomethyl auristatin E
Undisclosed
EP4461318A2 anti-PSMA ADC2 [433]
Humanized Anti-PSMA Antibody Variant 1
Glutamate carboxypeptidase 2 (FOLH1)
Monomethyl auristatin F
Undisclosed
EP4461318A2 anti-PSMA ADC3 [433]
Humanized Anti-PSMA Antibody Variant 1
Glutamate carboxypeptidase 2 (FOLH1)
Monomethyl auristatin F
CLeavable (Val-Citruline-PEG1) linker
EP4461318A2 anti-PSMA ADC4 [433]
Humanized Anti-PSMA Antibody Variant 1
Glutamate carboxypeptidase 2 (FOLH1)
Monomethyl auristatin F
Short Cleavable (Valine-Citruline-Acetyl)
EP4461318A2 anti-PSMA ADC5 [433]
Humanized Anti-PSMA Antibody Variant 1
Glutamate carboxypeptidase 2 (FOLH1)
Monomethyl auristatin E
Short Cleavable (Valine-Citruline-Acetyl)
EP4461318A2 anti-PSMA ADC6 [433]
Humanized Anti-PSMA Antibody Variant 2
Glutamate carboxypeptidase 2 (FOLH1)
Monomethyl auristatin E
Undisclosed
EP4461318A2 anti-PSMA ADC7 [433]
Humanized Anti-PSMA Antibody Variant 2
Glutamate carboxypeptidase 2 (FOLH1)
Monomethyl auristatin F
Undisclosed
EP4461318A2 anti-PSMA ADC8 [433]
Humanized Anti-PSMA Antibody Variant 2
Glutamate carboxypeptidase 2 (FOLH1)
Monomethyl auristatin F
CLeavable (Val-Citruline-PEG1) linker
EP4461318A2 anti-PSMA ADC9 [433]
Humanized Anti-PSMA Antibody Variant 2
Glutamate carboxypeptidase 2 (FOLH1)
Monomethyl auristatin F
Short Cleavable (Valine-Citruline-Acetyl)
EP4461318A2 anti-PSMA ADC10 [433]
Humanized Anti-PSMA Antibody Variant 2
Glutamate carboxypeptidase 2 (FOLH1)
Monomethyl auristatin E
Short Cleavable (Valine-Citruline-Acetyl)
EP4461318A2 anti-PSMA ADC11 [433]
Chimeric Anti-PSMA Antibody
Glutamate carboxypeptidase 2 (FOLH1)
Monomethyl auristatin E
Undisclosed
EP4461318A2 anti-PSMA ADC12 [433]
Chimeric Anti-PSMA Antibody
Glutamate carboxypeptidase 2 (FOLH1)
Monomethyl auristatin F
Undisclosed
EP4461318A2 anti-PSMA ADC13 [433]
Chimeric Anti-PSMA Antibody
Glutamate carboxypeptidase 2 (FOLH1)
Monomethyl auristatin F
CLeavable (Val-Citruline-PEG1) linker
EP4461318A2 anti-PSMA ADC14 [433]
Chimeric Anti-PSMA Antibody
Glutamate carboxypeptidase 2 (FOLH1)
Monomethyl auristatin F
Short Cleavable (Valine-Citruline-Acetyl)
EP4461318A2 anti-PSMA ADC15 [433]
Chimeric Anti-PSMA Antibody
Glutamate carboxypeptidase 2 (FOLH1)
Monomethyl auristatin E
Short Cleavable (Valine-Citruline-Acetyl)
CN118401256A ADC 1 [434]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
Allenamide-Amcap-Val-Cit-PABC
CN118401256A ADC 2 [434]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
Maleimido-caproyl-Val-Cit-PABC
CN118401256A ADC 3 [434]
Brentuximab
Tumor necrosis factor receptor superfamily member 8 (TNFRSF8)
Monomethyl auristatin E
Allenamide-Amcap-Val-Cit-PABC
CAT-10-106 [435]
Undisclosed
Tumor-associated calcium signal transducer 2 (TACSTD2)
Maytansine
Undisclosed
CAB-Axl-ADCm [436]
BA3011
Tyrosine-protein kinase receptor UFO (AXL)
Monomethyl auristatin E
Undisclosed
CAB-Axl-ADCf [436]
BA3011
Tyrosine-protein kinase receptor UFO (AXL)
Monomethyl auristatin F
Undisclosed
2A1-LC-Cys110ins-mc-vc-PAB-MMAE TDC [437]
2A1-LC-Cys110ins
Epidermal growth factor receptor variant III (EGFRvIII)
Monomethyl auristatin E
Mc-Val-Cit-PABC
2A1-LC-Cys111ins-mc-vc-PAB-MMAE TDC [437]
2A1-LC-Cys111ins
Epidermal growth factor receptor variant III (EGFRvIII)
Monomethyl auristatin E
Mc-Val-Cit-PABC
2A1-LC-Cys142ins-mc-vc-PAB-MMAE TDC [437]
2A1-LC-Cys142ins
Epidermal growth factor receptor variant III (EGFRvIII)
Monomethyl auristatin E
Mc-Val-Cit-PABC
2A1-LC-Cys272ins-mc-vc-PAB-MMAE TDC (1.74) [437]
2A1-LC-Cys271ins
Epidermal growth factor receptor variant III (EGFRvIII)
Monomethyl auristatin E
Mc-Val-Cit-PABC
2A1-LC-Cys272ins-mc-vc-PAB-MMAE TDC (1.77) [437]
2A1-LC-Cys272ins
Epidermal growth factor receptor variant III (EGFRvIII)
Monomethyl auristatin E
Mc-Val-Cit-PABC
2A1-LC-Cys275ins-mc-vc-PAB-MMAE TDC [437]
2A1-LC-Cys275ins
Epidermal growth factor receptor variant III (EGFRvIII)
Monomethyl auristatin E
Mc-Val-Cit-PABC
2A1-LC-Cys276ins-mc-vc-PAB-MMAE TDC [437]
2A1-LC-Cys276ins
Epidermal growth factor receptor variant III (EGFRvIII)
Monomethyl auristatin E
Mc-Val-Cit-PABC
2A1-LC-Cys381ins-mc-vc-PAB-MMAE TDC [437]
2A1-LC-Cys381ins
Epidermal growth factor receptor variant III (EGFRvIII)
Monomethyl auristatin E
Mc-Val-Cit-PABC
2A1-LC-Cys382ins-mc-vc-PAB-MMAE TDC [437]
2A1-LC-Cys382ins
Epidermal growth factor receptor variant III (EGFRvIII)
Monomethyl auristatin E
Mc-Val-Cit-PABC
2A1-LC-Cys384ins-mc-vc-PAB-MMAE TDC [437]
2A1-LC-Cys384
Epidermal growth factor receptor variant III (EGFRvIII)
Monomethyl auristatin E
Mc-Val-Cit-PABC
2A1-LC-Cys407ins-mc-vc-PAB-MMAE TDC [437]
2A1-LC-Cys407ins
Epidermal growth factor receptor variant III (EGFRvIII)
Monomethyl auristatin E
Mc-Val-Cit-PABC
2A1-LC-Cys408ins-mc-vc-PAB-MMAE TDC [437]
2A1-LC-Cys408ins
Epidermal growth factor receptor variant III (EGFRvIII)
Monomethyl auristatin E
Mc-Val-Cit-PABC
2A1-LC-Cys418ins-mc-vc-PAB-MMAE TDC [437]
2A1-LC-Cys418ins
Epidermal growth factor receptor variant III (EGFRvIII)
Monomethyl auristatin E
Mc-Val-Cit-PABC
2A1-LC-Cys419ins-mc-vc-PAB-MMAE TDC [437]
2A1-LC-Cys419ins
Epidermal growth factor receptor variant III (EGFRvIII)
Monomethyl auristatin E
Mc-Val-Cit-PABC
2A1-LC-Cys445ins-mc-vc-PAB-MMAE TDC [437]
2A1-LC-Cys445ins
Epidermal growth factor receptor variant III (EGFRvIII)
Monomethyl auristatin E
Mc-Val-Cit-PABC
ICAM1-MMAE 3.92 [438]
Undisclosed
Intercellular adhesion molecule 1 (ICAM1)
Monomethyl auristatin E
Mc-Val-Cit-PABC
ICAM1-MMAF 4.09 [438]
Undisclosed
Intercellular adhesion molecule 1 (ICAM1)
Monomethyl auristatin F
Mc-Val-Cit-PABC
ICAM1-DM1 3.96 [438]
Undisclosed
Intercellular adhesion molecule 1 (ICAM1)
Mertansine DM1
Mal-EBE-Mal
ICAM1-DM4 [438]
Undisclosed
Intercellular adhesion molecule 1 (ICAM1)
Mertansine DM4
Mal-EBE-Mal
KR1020240043161A 3G7-Sec-DM1 [439]
3G7
Endoplasmin homolog (LPG3)
Mertansine DM1
Undisclosed
US20230109312A1 ADC with 4 MMAF [440]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin F
US20230109312A1 ADC with 4 MMAF Linker
CX-2009 ADC [441]
CX-2009
CD166 antigen (ALCAM)
Mertansine DM4
SPDB
HuMab-CD74-005-vcMMAE [442]
HuMab-CD74-005
HLA class II histocompatibility antigen gamma chain (CD74)
Monomethyl auristatin E
Mc-Val-Cit-PABC
HuMab-CD74-006-vcMMAE [442]
HuMab-CD74-006
HLA class II histocompatibility antigen gamma chain (CD74)
Monomethyl auristatin E
Mc-Val-Cit-PABC
HuMab-CD74-011-vcMMAE [442]
HuMab-CD74-011
HLA class II histocompatibility antigen gamma chain (CD74)
Monomethyl auristatin E
Mc-Val-Cit-PABC
HuMab-CD74-005-mcMMAF [442]
HuMab-CD74-005
HLA class II histocompatibility antigen gamma chain (CD74)
Monomethyl auristatin F
Undisclosed
HuMab-CD74-006-mcMMAF [442]
HuMab-CD74-006
HLA class II histocompatibility antigen gamma chain (CD74)
Monomethyl auristatin F
Undisclosed
US20230256114A1 ADC (DAR4) 1 [443]
Anti-Trop
Tumor-associated calcium signal transducer 2 (TACSTD2)
Mertansine DM1
Succinimidyl-4- (N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
US20230256114A1 ADC (DAR4) 2 [443]
Anti-Trop
Tumor-associated calcium signal transducer 2 (TACSTD2)
Monomethyl auristatin E
Mc-Val-Cit-PABC
CM311-18D10-VH3/VL2-ADC [444]
CM311-18D10-VH3/VL2
Claudin-18.2 (CLDN18.2)
Monomethyl auristatin E
Mc-Val-Cit-PABC
CM311-18D10-VH6/VL1-ADC [444]
CM311-18D10-VH6/VL1
Claudin-18.2 (CLDN18.2)
Monomethyl auristatin E
Mc-Val-Cit-PABC
CM311-18D10-VH6/VL2-ADC [444]
CM311-18D10-VH6/VL2
Claudin-18.2 (CLDN18.2)
Monomethyl auristatin E
Mc-Val-Cit-PABC
CM311-18A9-VH7/VL2-ADC [444]
CM311-18A9-VH7/VL2
Claudin-18.2 (CLDN18.2)
Monomethyl auristatin E
Mc-Val-Cit-PABC
B62-H3L3-MMAE [445]
B62-H3L3
Inactive tyrosine-protein kinase transmembrane receptor ROR1 (ROR1)
Monomethyl auristatin E
Mc-Val-Cit-PABC
CN119371541A B31-H3L3-MMAE [445]
B31-H3L3
Inactive tyrosine-protein kinase transmembrane receptor ROR1 (ROR1)
Monomethyl auristatin E
Mc-Val-Cit-PABC
CN119371541A 99961.1-MMAE [445]
99961.1
Inactive tyrosine-protein kinase transmembrane receptor ROR1 (ROR1)
Monomethyl auristatin E
Mc-Val-Cit-PABC
AU2023226367A1-3 [446]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Auristatin E
RU20241285-3-linker
AU2023226367A1-3b [446]
CD20-A antibody
B-lymphocyte antigen CD20 (MS4A1)
Auristatin E
RU20241285-3-linker
AU2023226367A1-3c [446]
Imgatuzumab
Epidermal growth factor receptor (EGFR)
Auristatin E
RU20241285-3-linker
AU2023226367A1-7 [446]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
RU20241285-7-linker
AU2023226367A1-8 [446]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
RU20241285-8-linker
AU2023226367A1-14 [446]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Eribulin
RU20241285-8-linker
AU2023226367A1-16 [446]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Eribulin
EP4487874A1-18linker
AU2023226367A1-17 [446]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Eribulin
RU20241285-17-linker
AU2023226367A1-18 [446]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Eribulin
RU20241285-18-linker
AU2023226367A1-19 [446]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Auristatin E
RU20241285-19-linker
ZA202500202A 2188-D04-Y180/F404-LP1 [301]
2188-D04-Y180/F404
Inactive tyrosine-protein kinase transmembrane receptor ROR1 (ROR1)
SC209
DBCO-SO3-PEG4-Val-Cit-PABC
ZA202500202A 2188-D04-Y180/F404/K42-LP1 [301]
2188-D04-Y180/F404/K42
Inactive tyrosine-protein kinase transmembrane receptor ROR1 (ROR1)
SC209
DBCO-SO3-PEG4-Val-Cit-PABC
ZA202500202A D04-Y180/F404/K42/E161-LP12 [301]
D04-Y180/F404/K42/E161
Inactive tyrosine-protein kinase transmembrane receptor ROR1 (ROR1)
SC209
DBCO sidechain PEG12 ValLys-pAB
ZA202500202A D04-Y180/F404/K42/E161-LP13 [301]
D04-Y180/F404/K42/E161
Inactive tyrosine-protein kinase transmembrane receptor ROR1 (ROR1)
SC209
DBCO sidechain PEG12 ValGlu-pAB
ZA202500202A D04-Y180/F404/K42/E161-LP1 7.99 [301]
D04-Y180/F404/K42/E161
Inactive tyrosine-protein kinase transmembrane receptor ROR1 (ROR1)
SC209
DBCO-SO3-PEG4-Val-Cit-PABC
ZA202500202A D04-Y180/F404/K42/E161-LP1 7.95 [301]
D04-Y180/F404/K42/E161
Inactive tyrosine-protein kinase transmembrane receptor ROR1 (ROR1)
SC209
DBCO-SO3-PEG4-Val-Cit-PABC
ZA202500202A D04-Y180/F404-LP11 [301]
D04-Y180/F404
Inactive tyrosine-protein kinase transmembrane receptor ROR1 (ROR1)
Monomethyl auristatin E
DBCO-SO3-PEG4-Val-Cit-PABC
ZA202500202A D04-Y180/F404-LP1 [301]
D04-Y180/F404
Inactive tyrosine-protein kinase transmembrane receptor ROR1 (ROR1)
SC209
DBCO-SO3-PEG4-Val-Cit-PABC
ZA202500202A D04-Y180F404/K42/E161-LP1 [301]
D04-Y180F404/K42/E161
Inactive tyrosine-protein kinase transmembrane receptor ROR1 (ROR1)
SC209
DBCO-SO3-PEG4-Val-Cit-PABC
ZA202500114A-ADC-1 [447]
ZA202500114A-mAb-1
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
Undisclosed
ZA202500114A-ADC-4 [447]
Anti-TROP2 mAb
Tumor-associated calcium signal transducer 2 (TACSTD2)
Monomethyl auristatin E
Undisclosed
ZA202500114A-ADC-5 [447]
Anti-TROP2 mAb
Tumor-associated calcium signal transducer 2 (TACSTD2)
Monomethyl auristatin E
Undisclosed
mL49-MDpr-PEG (12)gluc-MMAE [448]
mouse L49
Melanotransferrin (MELTF)
Monomethyl auristatin E
MDpr-PEG (12)gluc
cL49-MDpr-PEG (12)-gluc-MMAE [448]
Chimeric L49
Melanotransferrin (MELTF)
Monomethyl auristatin E
MDpr-PEG (12)gluc
mL235-MDpr-PEG (12)-gluc-MMAE [448]
mouse L235
Melanotransferrin (MELTF)
Monomethyl auristatin E
MDpr-PEG (12)gluc
Santa Cruz (#271633)-MDpr-PEG (12)gluc-MMAE [448]
Santa Cruz (#271633)
Melanotransferrin (MELTF)
Monomethyl auristatin E
MDpr-PEG (12)gluc
R&D (#893416)-MDpr-PEG (12)-gluc-MMAE [448]
R&D (#893416)
Melanotransferrin (MELTF)
Monomethyl auristatin E
MDpr-PEG (12)gluc
Biolegend (#363101)-MDpr-PEG (12)-gluc-MMAE [448]
Biolegend (#363101)
Melanotransferrin (MELTF)
Monomethyl auristatin E
MDpr-PEG (12)gluc
hIgG-MDpr-PEG (12)-gluc-MMAE [448]
humanIgG
Melanotransferrin (MELTF)
Monomethyl auristatin E
MDpr-PEG (12)gluc
hL49-HALC-MDpr-PEG (12)-gluc-MMAE [448]
hL49-HALC
Melanotransferrin (MELTF)
Monomethyl auristatin E
MDpr-PEG (12)gluc
hL49-HALC-MC-VC-MMAE [448]
hL49-HALC
Melanotransferrin (MELTF)
Monomethyl auristatin E
Mc-Val-Cit-PABC
Trastuzumab N221 (WT)-MMAF #1 [449]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin F
Undisclosed
Trastuzumab N221 (WT)-MMAF #2 [449]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin F
Undisclosed
Trastuzumab N221 (GDLN)-MMAF [449]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin F
Undisclosed
Tras-LN-MMAF [449]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin F
Undisclosed
Tras.D221N-MMAF (HEK GDLN) [449]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin F
Undisclosed
Tras.D221N-MMAF (HEK WT) [449]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin F
Undisclosed
MER-M6 [450]
M6
Tyrosine-protein kinase Mer (MERTK)
Monomethyl auristatin F
Undisclosed
AbA-vcMMAE [451]
AbA
Epidermal growth factor receptor (EGFR)
Monomethyl auristatin E
Mc-Val-Cit-PABC
BAP048.7-mc-VC-PAB-MMAE [452]
BAP048.7
Tyrosine-protein kinase transmembrane receptor ROR2 (ROR2)
Monomethyl auristatin E
Mc-Val-Cit-PABC
BAP048.7-mc-PEG8-vC-PAB-MMAE [452]
BAP048.7
Tyrosine-protein kinase transmembrane receptor ROR2 (ROR2)
Monomethyl auristatin E
Mal-PEG8-Val-Cit-PAB
FS001-VH4-VL1-VC-MMAE [453]
FS001-huVH4-huVL1
Glypican-3 (GPC3)
Monomethyl auristatin E
Mc-Val-Cit-PABC
FS001-VH3-VL2-Vc-MMAE [453]
FS001-huVH3-huVL2
Glypican-3 (GPC3)
Monomethyl auristatin E
Mc-Val-Cit-PABC
FS001-VH4-VL2-vc-MMAE [453]
FS001-huVH4-huVL2
Glypican-3 (GPC3)
Monomethyl auristatin E
Mc-Val-Cit-PABC
FS001-VH4-VL3-VC-MMAE [453]
FS001-huVH4-huVL3
Glypican-3 (GPC3)
Monomethyl auristatin E
Mc-Val-Cit-PABC
Anti-Trop2- (Q295-mcValCitPABC-A6)- (mcMMAF) [454]
Trastuzumab
Tumor-associated calcium signal transducer 2 (TACSTD2)
Monomethyl auristatin F
Undisclosed
Anti-Her2- (Q295-mcValCitPABC-A6)- (mcMMAF) [454]
Sacituzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin F
Undisclosed
Anti-Trop2- (Q295-mcA6)- (mcMMMAF) [454]
Trastuzumab
Tumor-associated calcium signal transducer 2 (TACSTD2)
Monomethyl auristatin F
Undisclosed
Anti-Her2- (0295-mcA6)- (mcMMAF) [454]
Sacituzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin F
Undisclosed
Anti-Trop2- (Q295-mcMMAF)- (mcValCitPABC-A6) [454]
Trastuzumab
Tumor-associated calcium signal transducer 2 (TACSTD2)
Monomethyl auristatin F
Undisclosed
Anti-Her2- (0295-mcMMAF)- (mcValCitPABC-A6) [454]
Sacituzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin F
Undisclosed
Anti-Trop2- (0295-mcMMAF)- (mc-A6) [454]
Trastuzumab
Tumor-associated calcium signal transducer 2 (TACSTD2)
Monomethyl auristatin F
Undisclosed
Anti-Her2- (0295-mcMMAF)- (mc-A6) [454]
Sacituzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin F
Undisclosed
Anti-Trop2- (Q295-mcMMAE)- (mc-A6) [454]
Trastuzumab
Tumor-associated calcium signal transducer 2 (TACSTD2)
Monomethyl auristatin E
Undisclosed
Trop2-Saci- (mc-MMAF)- (McAsnAsn-A6) [454]
Trastuzumab
Tumor-associated calcium signal transducer 2 (TACSTD2)
Monomethyl auristatin F
Undisclosed
Trop2-Saci- (mc-MMAF)- (mc-A6) [454]
Trastuzumab
Tumor-associated calcium signal transducer 2 (TACSTD2)
Monomethyl auristatin F
Undisclosed
Her2-Saci- (mc-MMAF)- (McAsnAsn-A6) [454]
Sacituzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin F
Undisclosed
Her2-Saci- (mc-MMAF)- (mc-A6) [454]
Sacituzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin F
Undisclosed
hlgG-MMAE [455]
Undisclosed
Seizure 6-like protein 2 (SEZ6L2)
Monomethyl auristatin E
Undisclosed
MOJ008268C 3E2-MMAE [455]
300
Seizure 6-like protein 2 (SEZ6L2)
Monomethyl auristatin E
Undisclosed
MOJ008268C 3A1-MMAE [455]
3A1
Seizure 6-like protein 2 (SEZ6L2)
Monomethyl auristatin E
Undisclosed
ISO-ADC [456]
Undisclosed
Trophoblast glycoprotein (TPBG)
Monomethyl auristatin E
Undisclosed
WO2024193682A1 32G1-2F11-ADC [456]
Undisclosed
Trophoblast glycoprotein (TPBG)
Monomethyl auristatin E
Undisclosed
WO2024193682A1 32G1-8H10-ADC [456]
Undisclosed
Trophoblast glycoprotein (TPBG)
Monomethyl auristatin E
Undisclosed
WO2024193682A1 32G1-8D9-ADC [456]
Undisclosed
Trophoblast glycoprotein (TPBG)
Monomethyl auristatin E
Undisclosed
Telisotuzumab-ADC [456]
Undisclosed
Trophoblast glycoprotein (TPBG)
Monomethyl auristatin E
Undisclosed
PF06263507-ADC [456]
Undisclosed
Trophoblast glycoprotein (TPBG)
Monomethyl auristatin E
Undisclosed
WO2024193682A1 32G1-ADC [456]
32G1
Trophoblast glycoprotein (TPBG)
Monomethyl auristatin E
Undisclosed
WO2024193682A1 8H10-ADC [456]
8H10
Trophoblast glycoprotein (TPBG)
Monomethyl auristatin E
Undisclosed
WO2024193682A1 8D9-ADC [456]
8D9
Trophoblast glycoprotein (TPBG)
Monomethyl auristatin E
Undisclosed
FM2b-S-D2 [457]
FM2b-S
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
Mc-Val-Cit-PABC
FM2b-F-D2 [457]
FM2b-F
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
Mc-Val-Cit-PABC
FM2b-K-D2 [457]
FM2b-K
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
Mc-Val-Cit-PABC
FM2b-Y-D2 [457]
FM2b-Y
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
Mc-Val-Cit-PABC
BB02E-MMAE [458]
BB02E
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
Mc-Val-Cit-PABC
BB03E-MMAE [458]
BB03E
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
Mc-Val-Cit-PABC
BB03E-A-MMAE [458]
BB03E-A
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
Mc-Val-Cit-PABC
BB04E-MMAE [458]
BB04E
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
Mc-Val-Cit-PABC
BB05E-MMAE [458]
BB05E
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
Mc-Val-Cit-PABC
Degly-ISOmAb-1-mc-vc-PAB-MMAE [459]
degly-ISOmAb
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
Mc-Val-Cit-PABC
Degly-mAb1-1-mc-vc-PAB-MMAE [459]
degly-mAb1
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
Mc-Val-Cit-PABC
mAb1-mc-vc-PAB-MMAE [459]
mAb1
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
Mc-Val-Cit-PABC
IN202317039249 ACD6-ADC [460]
Undisclosed
T-cell differentiation antigen CD6 (CD6)
Monomethyl auristatin E
Mc-Val-Cit-PABC
mIgG-ADC [460]
Undisclosed
T-cell differentiation antigen CD6 (CD6)
Monomethyl auristatin E
Mc-Val-Cit-PABC
W3195-1.53.1-p1-ulgG11-MMAE [461]
W3195-1.53.1-p1-ulgG11
Cadherin-3 (CDH3)
Monomethyl auristatin E
Mc-Val-Cit-PABC
WBP319-BMK4.uIgG1k-DM1 [461]
WBP319-BMK4.uIgG1k
Cadherin-3 (CDH3)
Mertansine DM1
Succinimidyl-4- (N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
TWI852077B-J1 [462]
Anti-cKIT Fab'1
Mast/stem cell growth factor receptor Kit (KIT)
Monomethyl auristatin E
TWI852077B-C1-linker
TWI852077B-J2 [462]
Anti-cKIT Fab'2
Mast/stem cell growth factor receptor Kit (KIT)
Monomethyl auristatin E
TWI852077B-C1-linker
TWI852077B-J3 [462]
Anti-cKIT Fab'3
Mast/stem cell growth factor receptor Kit (KIT)
Monomethyl auristatin E
TWI852077B-C1-linker
TWI852077B-J4 [462]
Anti-cKIT Fab'4
Mast/stem cell growth factor receptor Kit (KIT)
Monomethyl auristatin E
TWI852077B-C1-linker
TWI852077B-J5 [462]
Anti-cKIT Fab'5
Mast/stem cell growth factor receptor Kit (KIT)
Monomethyl auristatin E
TWI852077B-C1-linker
TWI852077B-J6 [462]
Anti-Her2Fab'
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
TWI852077B-C1-linker
TWI852077B-J9 [462]
Anti-cKIT F (ab'4)2
Mast/stem cell growth factor receptor Kit (KIT)
TWI852077B-C4-payload
TWI852077B-C4-linker
TWI852077B-J11 [462]
Anti-cKIT Fab3
Mast/stem cell growth factor receptor Kit (KIT)
TWI852077B-C4-payload
TWI852077B-C4-linker
TWI852077B-J12 [462]
Anti-cKIT F (ab')2
Mast/stem cell growth factor receptor Kit (KIT)
TWI852077B-C4-payload
TWI852077B-C4-linker
TWI852077B-J14 [462]
Anti-cKIT Fab'1
Mast/stem cell growth factor receptor Kit (KIT)
Monomethyl auristatin F
Mc-Val-Cit-PABC
TWI852077B-J16 [462]
Anti-cKIT Fab'1
Mast/stem cell growth factor receptor Kit (KIT)
Monomethyl auristatin E
TWI852077B-C1-linker
TWI852077B-J17 [462]
Anti-cKIT Fab'2
Mast/stem cell growth factor receptor Kit (KIT)
Monomethyl auristatin F
Mc-Val-Cit-PABC
TWI852077B-J19 [462]
Anti-cKIT Fab'2
Mast/stem cell growth factor receptor Kit (KIT)
Monomethyl auristatin E
TWI852077B-C1-linker
TWI852077B-J20 [462]
Anti-cKIT Fab'3
Mast/stem cell growth factor receptor Kit (KIT)
Monomethyl auristatin F
Mc-Val-Cit-PABC
TWI852077B-J22 [462]
Anti-cKIT Fab'3
Mast/stem cell growth factor receptor Kit (KIT)
Monomethyl auristatin E
TWI852077B-C1-linker
TWI852077B-J23 [462]
Anti-cKIT Fab'5
Mast/stem cell growth factor receptor Kit (KIT)
Monomethyl auristatin E
TWI852077B-C1-linker
TWI852077B-J24 [462]
Anti-cKIT Fab'5
Mast/stem cell growth factor receptor Kit (KIT)
Monomethyl auristatin E
TWI852077B-C1-linker
TWI852077B-J25 [462]
Anti-cKIT Fab'5
Mast/stem cell growth factor receptor Kit (KIT)
Monomethyl auristatin F
Mc-Val-Cit-PABC
TWI852077B-JW [462]
Anti-cKIT Fab'2
Mast/stem cell growth factor receptor Kit (KIT)
Monomethyl auristatin E
TWI852077B-C1-linker
TWI852078B-JX [462]
Anti-cKIT Fab'2
Mast/stem cell growth factor receptor Kit (KIT)
Monomethyl auristatin F
Mc-Val-Cit-PABC
TWI852079B-JY [462]
Anti-cKIT Fab'3
Mast/stem cell growth factor receptor Kit (KIT)
Monomethyl auristatin E
TWI852077B-C1-linker
TWI852080B-JZ [462]
Anti-cKIT Fab'3
Mast/stem cell growth factor receptor Kit (KIT)
Monomethyl auristatin F
Mc-Val-Cit-PABC
P015004-vc-PAB-MMAE [463]
P015004
Inactive tyrosine-protein kinase transmembrane receptor ROR1 (ROR1)
Monomethyl auristatin E
Mc-Val-Cit-PABC
P015042-vc-PAB-MMAE [463]
P015042
Inactive tyrosine-protein kinase transmembrane receptor ROR1 (ROR1)
Monomethyl auristatin E
Mc-Val-Cit-PABC
P015043-vc-PAB-MMAE [463]
P015043
Inactive tyrosine-protein kinase transmembrane receptor ROR1 (ROR1)
Monomethyl auristatin E
Mc-Val-Cit-PABC
P015044-vc-PAB-MMAE [463]
P015044
Inactive tyrosine-protein kinase transmembrane receptor ROR1 (ROR1)
Monomethyl auristatin E
Mc-Val-Cit-PABC
UC961-vc-PAB-MMAE [463]
UC961
Inactive tyrosine-protein kinase transmembrane receptor ROR1 (ROR1)
Monomethyl auristatin E
Mc-Val-Cit-PABC
LC0HC0-VC-MMAE [464]
LC0HC0
C-type mannose receptor 2 (MRC2)
Monomethyl auristatin E
Mc-Val-Cit-PABC
LC4HC3-VC-MMAE [464]
LC4HC3
C-type mannose receptor 2 (MRC2)
Monomethyl auristatin E
Mc-Val-Cit-PABC
RKAAR-PABC-MMAE [465]
RKAAR
Undisclosed
Monomethyl auristatin E
Mc-Val-Cit-PABC
RRKAY-PABC-MMAE [465]
RRKAY
Undisclosed
Monomethyl auristatin E
Mc-Val-Cit-PABC
RRK-PABC-MMAE [465]
RRK
Undisclosed
Monomethyl auristatin E
Mc-Val-Cit-PABC
ARKRA-PABC-MMAE [465]
ARKRA
Undisclosed
Monomethyl auristatin E
Mc-Val-Cit-PABC
RKAA-PABC-MMAE [465]
RKAA
Undisclosed
Monomethyl auristatin E
Mc-Val-Cit-PABC
KAR-PABC-MMAE [465]
KAR
Undisclosed
Monomethyl auristatin E
Mc-Val-Cit-PABC
EP3838893B1-ADC-I [466]
mil40
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
Mm-C3-Val-Ala-PAB
EP3838893B1-ADC-II [466]
mil40
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
Mm-C6-Val-Ala-PAB
EP3838893B1-ADC-III [466]
mil40
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
Mm-C6-Val-Cit-PAB
EP3838893B1-ADC-A [466]
mil40
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
Mm-C6-PEG4-Val-Ala-PAB
EP3838893B1-ADC-B [466]
mil40
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
Mm-C6-PEG8-Val-Ala-PAB
EP3838893B1-ADC-C [466]
mil40
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
Mm-C6-PEG8'-Val-Ala-PAB
Su-C6-Val-Cit-PAB [466]
mil40
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
Mc-Val-Cit-PABC
Maa-C6-Val-Ala-PAB-MMAE [466]
Undisclosed
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
Maa-C6-Val-Ala-PAB
Maa-C6-Val-Cit-PAB-MMAE [466]
Undisclosed
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
Maa-C6-Val-Cit-PAB
Mf-C6-Val-Ala-PAB-MMAE [466]
Undisclosed
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
Mm-C6-Val-Ala-PAB
Mf-C3-Val-Ala-PAB-MMAE [466]
Undisclosed
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
Mm-C3-Val-Ala-PAB
Mf-C6-Val-Cit-PAB-MMAE [466]
Undisclosed
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
Mf-C6-Val-Cit-PAB
Mm-C6-Val-Ala-PAB-MMAE [466]
Undisclosed
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
Mm-C6-Val-Ala-PAB
Mm-C3-Val-Ala-PAB-MMAE [466]
Undisclosed
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
Mm-C3-Val-Ala-PAB
Mm-C6-Val-Cit-PAB-MMAE [466]
Undisclosed
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
Mm-C6-Val-Cit-PAB
Mm-C6-PEG4-Val-Ala-PAB-MMAE [466]
mil40
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
Mm-C6-PEG4-Val-Ala-PAB
Mm-C6-PEG8-Val-Ala-PAB-MMAE [466]
mil40
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
Mm-C6-PEG8-Val-Ala-PAB
Mm-C6-PEG8'-Val-Ala-PAB-MMAE [466]
mil40
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
Mm-C6-PEG8'-Val-Ala-PAB
Su-C3-VA [466]
mil40
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
PEG2-Val-Cit-PABC
Su-C6-VC [466]
mil40
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
Mc-Val-Cit-PABC
Su-C6-VA [466]
mil40
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
Mc-Val-Ala-PABC
WO2024140927A1-ADC-A (DAR4) [467]
mAb-A
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
Mc-Val-Cit-PABC
WO2024140927A1-ADC-B (DAR4) [467]
mAb-B
Undisclosed
Monomethyl auristatin E
Mc-Val-Cit-PABC
WO2024140927A1-ADC-C (DAR2) [467]
mAb-C
Tumor necrosis factor (TNF)
Monomethyl auristatin E
Mc-Val-Cit-PABC
WO2024140927A1-ADC-C (DAR4) [467]
mAb-C
Tumor necrosis factor (TNF)
Monomethyl auristatin E
Mc-Val-Cit-PABC
WO2024140927A1-ADC-C (DAR7) [467]
mAb-C
Tumor necrosis factor (TNF)
Monomethyl auristatin E
Mc-Val-Cit-PABC
WO2024140927A1-ADC-A (DAR6) [467]
mAb-A
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
Mc-Val-Cit-PABC
WO2024140927A1-ADC-A (DAR2) [467]
mAb-A
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
Mc-Val-Cit-PABC
T (kK183C+K290C)-VC0101 ADC [468]
T (kK183C+K290C)
Receptor tyrosine-protein kinase erbB-2 (HER2)
Auristatin 0101
Mc-Val-Cit-PABC
WO2023047090A1-MMAE ADC [468]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
Undisclosed
AU2022395626A1 ADC-H1-P1 [469]
Trastuzumab-K249
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
H-Tet-PEG9-Val-Ala-PAB
AU2022395626A1 ADC-H1-P2 [469]
Trastuzumab-K249
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
H-Tet-Glucuronide
AU2022395626A1 ADC-H2-P1 [469]
Trastuzumab-K251
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
H-Tet-PEG9-Val-Ala-PAB
AU2022395626A1 ADC-H3-P1 [469]
Trastuzumab-K291
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
H-Tet-PEG9-Val-Ala-PAB
AU2022395626A1 ADC-H4-P1 [469]
Trastuzumab-K320
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
H-Tet-PEG9-Val-Ala-PAB
AU2022395626A1 ADC-H4-P2 [469]
Trastuzumab-K320
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
H-Tet-Glucuronide
AU2022395626A1 ADC-H5-P1 [469]
Trastuzumab-K343
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
H-Tet-PEG9-Val-Ala-PAB
AU2022395626A1 ADC-H6-P2 [469]
Trastuzumab-P41
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
H-Tet-Glucuronide
AU2022395626A1 ADC-H7-P2 [469]
Trastuzumab-G42
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
H-Tet-Glucuronide
AU2022395626A1 ADC-L1-P2 [469]
Trastuzumab-A51
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
H-Tet-Glucuronide
AU2022395626A1 ADC-L2-P2 [469]
Trastuzumab-A111
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
H-Tet-Glucuronide
AU2022395626A1 ADC-L3-P2 [469]
Trastuzumab-K169
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
H-Tet-Glucuronide
AU2022395626A1 ADC-L4-P2 [469]
Trastuzumab-G41
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
H-Tet-Glucuronide
AU2022395626A1 ADC-L5-P2 [469]
Trastuzumab-P59
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
H-Tet-Glucuronide
AU2022395626A1 ADC-H1H4-P2 [469]
Trastuzumab-K249&K320
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
H-Tet-Glucuronide
AU2022395626A1 ADC-H1H5-P2 [469]
Trastuzumab-K249&K343
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
H-Tet-Glucuronide
AU2022395626A1 ADC-H1L3-P2 [469]
Trastuzumab-K249&K169
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
H-Tet-Glucuronide
AU2022395626A1 ADC-H1L4-P2 [469]
Trastuzumab-K249&G41
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
H-Tet-Glucuronide
AU2022395626A1 ADC-H4L3-P2 [469]
Trastuzumab-K320&K169
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
H-Tet-Glucuronide
AU2022395626A1 ADC-H4L4-P2 [469]
Trastuzumab-K320&G41
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
H-Tet-Glucuronide
AU2022395626A1 ADC-H6L4-P2 [469]
Trastuzumab-P41&G41
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
H-Tet-Glucuronide
GlyADC-H1-P2 [469]
Trastuzumab-K249
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
H-Tet-Glucuronide
GlyADC-H4-P2 [469]
Trastuzumab-K320
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
H-Tet-Glucuronide
LN474-63 [470]
STI-1260
Tumor necrosis factor receptor superfamily member 17 (TNFRSF17)
Monomethyl auristatin E
CN118079014A-linker-1
LN437-99 [470]
BY016
Tumor-associated calcium signal transducer 2 (TACSTD2)
Monomethyl auristatin E
CN118079014A-linker-2
LN474-64 [470]
STI-1260
Tumor necrosis factor receptor superfamily member 17 (TNFRSF17)
Monomethyl auristatin E
CN118079014A-linker-3
Hu001-2-MMAE [471]
Hu001-2
Inactive tyrosine-protein kinase transmembrane receptor ROR1 (ROR1)
Monomethyl auristatin E
Mc-Val-Cit-PABC
Hu001-3-MMAE [471]
Hu001-3
Inactive tyrosine-protein kinase transmembrane receptor ROR1 (ROR1)
Monomethyl auristatin E
Mc-Val-Cit-PABC
Hu005-44-MMAE [471]
Hu005-44
Inactive tyrosine-protein kinase transmembrane receptor ROR1 (ROR1)
Monomethyl auristatin E
Mc-Val-Cit-PABC
Hu005-46-MMAE [471]
Hu005-46
Inactive tyrosine-protein kinase transmembrane receptor ROR1 (ROR1)
Monomethyl auristatin E
Mc-Val-Cit-PABC
UC961-MMAE [471]
UC961
Inactive tyrosine-protein kinase transmembrane receptor ROR1 (ROR1)
Monomethyl auristatin E
Mc-Val-Cit-PABC
mAb001c-vc-MMAE [471]
mAb001c
Inactive tyrosine-protein kinase transmembrane receptor ROR1 (ROR1)
Monomethyl auristatin E
Mc-Val-Cit-PABC
WO2024092067A1 2E7-vedotin [472]
20000000
CD70 antigen (CD70)
Monomethyl auristatin E
Mc-Val-Cit-PABC
hz26A12C1H4L3-MMAE [473]
hz26A12C1H4L3
Neural cell adhesion molecule L1 (L1CAM)
Monomethyl auristatin E
Mc-Val-Cit-PABC
hz46F1D5H4L3-MMAE [473]
hz46F1D5H4L3
Neural cell adhesion molecule L1 (L1CAM)
Monomethyl auristatin E
Mc-Val-Cit-PABC
hz49E10H1H5L6-MMAE [473]
hz49E10H1H5L6
Neural cell adhesion molecule L1 (L1CAM)
Monomethyl auristatin E
Mc-Val-Cit-PABC
hz49E10H1H5L7-MMAE [473]
hz49E10H1H5L7
Neural cell adhesion molecule L1 (L1CAM)
Monomethyl auristatin E
Mc-Val-Cit-PABC
hz103E9B3H5L5-MMAE [473]
hz103E9B3H5L5
Neural cell adhesion molecule L1 (L1CAM)
Monomethyl auristatin E
Mc-Val-Cit-PABC
hz103E9B3H6L5-MMAE [473]
hz103E9B3H6L5
Neural cell adhesion molecule L1 (L1CAM)
Monomethyl auristatin E
Mc-Val-Cit-PABC
EDB-L19-vc-0101 [474]
EDB-L19
Vesicle-associated membrane protein 8 (VAMP8)
Auristatin 0101
Mc-Val-Cit-PABC
EDB- (κK183C-K290C)-vc-0101 [474]
EDB- (kK183C-K290C)
Vesicle-associated membrane protein 8 (VAMP8)
Auristatin 0101
Mc-Val-Cit-PABC
EDB- (K94R)-vc-0101 [474]
EDB- (K94R)
Vesicle-associated membrane protein 8 (VAMP8)
Auristatin 0101
Mc-Val-Cit-PABC
EDB- (κK183C-K94R-K290C)-vc-0101 [474]
EDB- (kK183C-K94R-K290C)
Vesicle-associated membrane protein 8 (VAMP8)
Auristatin 0101
Mc-Val-Cit-PABC
EDB-L19-diS-DM1 [474]
EDB-L19
Vesicle-associated membrane protein 8 (VAMP8)
Mertansine DM1
Dis linker
IN202417103159A 2188-D04-Yl80/F404-LP1 [475]
Undisclosed
Inactive tyrosine-protein kinase transmembrane receptor ROR1 (ROR1)
SC209
DBCO-Val-Cit-PABC
IN202417103159A 2188-D04-Yl80/F404/K42-LP1 [475]
Undisclosed
Inactive tyrosine-protein kinase transmembrane receptor ROR1 (ROR1)
SC209
DBCO-Val-Cit-PABC
IN202417103159A 2188-D04-Yl80/F404/K42/E161-LP1 [475]
Undisclosed
Inactive tyrosine-protein kinase transmembrane receptor ROR1 (ROR1)
SC209
DBCO-Val-Cit-PABC
IN202417103159A D04-Y180/F404/K42/E161-LP12 [475]
Undisclosed
Inactive tyrosine-protein kinase transmembrane receptor ROR1 (ROR1)
SC209
DBCO sidechain PEG12 ValLys-pAB
IN202417103159A D04-Y180/F404/K42/E161-LP13 [475]
Undisclosed
Inactive tyrosine-protein kinase transmembrane receptor ROR1 (ROR1)
SC209
DBCO sidechain PEG12 ValGlu-pAB
IN202417103159A D04-Y180/F404/K42/E161-LP1 [475]
Undisclosed
Inactive tyrosine-protein kinase transmembrane receptor ROR1 (ROR1)
SC209
Undisclosed
IN202417103159A D04-Yl80/F404/K42/E161-LP1 [475]
Undisclosed
Inactive tyrosine-protein kinase transmembrane receptor ROR1 (ROR1)
SC209
DBCO-SO3-PEG4-Val-Cit-PABC
IN202417103159A D04-Yl80/F404-LP11 [475]
Undisclosed
Inactive tyrosine-protein kinase transmembrane receptor ROR1 (ROR1)
Monomethyl auristatin E
DBCO-SO3-PEG4-Val-Cit-PABC
IN202417103159A D04-Yl80/F404-LP1 [475]
Undisclosed
Inactive tyrosine-protein kinase transmembrane receptor ROR1 (ROR1)
SC209
DBCO-SO3-PEG4-Val-Cit-PABC
IN202417103159A D04-Yl80F404/K42/E161-LP23 [475]
Undisclosed
Inactive tyrosine-protein kinase transmembrane receptor ROR1 (ROR1)
SC209
Undisclosed
IN202417103159A D04-Yl80F404/K42/E161-LP22 [475]
Undisclosed
Inactive tyrosine-protein kinase transmembrane receptor ROR1 (ROR1)
SC209
DBCO-nnAA-PEG13-AAN
IN202417103159A D04-Yl80F404/K42/E161-LP1 [475]
Undisclosed
Inactive tyrosine-protein kinase transmembrane receptor ROR1 (ROR1)
SC209
DBCO-SO3-PEG4-Val-Cit-PABC
RC88-Py-MAA-Val-Cit-PAB-MMAE [476]
RC88
Mesothelin (MSLN)
Monomethyl auristatin E
PY-MAA-Val-Cit-PABC
RC88-Mc-Val-Cit-PAB-MMAE [476]
RC88
Mesothelin (MSLN)
Monomethyl auristatin E
Mc-Val-Cit-PABC
IN202417078684A+ADC1 [477]
IN202417078684A+Ab1
Undisclosed
Mertansine DM1
Succinimidyl-4- (N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
IN202417078684A+ADC2 [477]
IN202417078684A+Ab2
Undisclosed
Mertansine DM1
Succinimidyl-4- (N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
IN202417078684A+ADC3 [477]
IN202417078684A+Ab3
Undisclosed
Mertansine DM1
Succinimidyl-4- (N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
IN202417078684A+ADC4 [477]
IN202417078684A+Ab4
Undisclosed
Mertansine DM1
Succinimidyl-4- (N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
IN202417078684A+ADC5 [477]
IN202417078684A+Ab4
Undisclosed
Mertansine DM4
SPDB
IN202417078684A+ADC6 [477]
IN202417078684A+Ab4
Undisclosed
Monomethyl auristatin E
Mc-Val-Cit-PABC
IN202417078684A+ADC9 [477]
IN202417078684A+Ab4
Undisclosed
Monomethyl auristatin F
Mc-Val-Cit-PABC
HG4K IgG4-Linker-DM1 (2) [478]
HG4K IgG4
Basal cell adhesion molecule (BCAM)
Mertansine DM1
Undisclosed
Abl-Linker-DM1 [478]
Ab1
Nectin-4 (NECTIN4)
Mertansine DM1
Undisclosed
Abl-Linker-MMAF [478]
Ab1
Nectin-4 (NECTIN4)
Monomethyl auristatin F
Undisclosed
WO2024107014A1 Ab3-Linker-MMAF [478]
Ab3
Nectin-4 (NECTIN4)
Monomethyl auristatin F
Undisclosed
HG4K IgG4-Linker-MMAF (3) [478]
HG4K IgG4
Basal cell adhesion molecule (BCAM)
Monomethyl auristatin F
Undisclosed
CO20240013452A2 ADC1 [479]
B62-H3L3
Inactive tyrosine-protein kinase transmembrane receptor ROR1 (ROR1)
Monomethyl auristatin E
Mc-Val-Cit-PABC
CO20240013452A2 ADC1 (2) [479]
B31-H3L3
Inactive tyrosine-protein kinase transmembrane receptor ROR1 (ROR1)
Monomethyl auristatin E
Mc-Val-Cit-PABC
CO20240013452A2 99961-MMAE [479]
99961.1
Inactive tyrosine-protein kinase transmembrane receptor ROR1 (ROR1)
Monomethyl auristatin E
Mc-Val-Cit-PABC
EP4495597A2 1F-MMAE [480]
1F
Tissue factor (F3)
Monomethyl auristatin E
Mc-Val-Cit-PABC
EP4495597A2 25A-MMAE [480]
25A
Tissue factor (F3)
Monomethyl auristatin E
Mc-Val-Cit-PABC
EP4495597A2 25A3-MMAE [480]
25A3
Tissue factor (F3)
Monomethyl auristatin E
Mc-Val-Cit-PABC
EP4495597A2 25G1-MMAE [480]
25G1
Tissue factor (F3)
Monomethyl auristatin E
Mc-Val-Cit-PABC
EP4495597A2 29E-MMAE [480]
29E
Tissue factor (F3)
Monomethyl auristatin E
Mc-Val-Cit-PABC
EP4495597A2 39A-MMAE [480]
39A
Tissue factor (F3)
Monomethyl auristatin E
Mc-Val-Cit-PABC
EP4495597A2 43B1-MMAE [480]
43B1
Tissue factor (F3)
Monomethyl auristatin E
Mc-Val-Cit-PABC
EP4495597A2 43D7-MMAE [480]
43D7
Tissue factor (F3)
Monomethyl auristatin E
Mc-Val-Cit-PABC
EP4495597A2 43Ea-MMAE [480]
43Ea
Tissue factor (F3)
Monomethyl auristatin E
Mc-Val-Cit-PABC
EP4495597A2 54E-MMAE [480]
54E
Tissue factor (F3)
Monomethyl auristatin E
Mc-Val-Cit-PABC
anti-EGFR Ab No.1 (L328C)-vcMMAE [481]
EGFR No.1 (L328C)
Epidermal growth factor receptor (EGFR)
Monomethyl auristatin E
Mc-Val-Cit-PABC
anti-HER2 Ab (L328C)-vcMMAE [481]
HER2 (L328C)
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
Mc-Val-Cit-PABC
anti-TROP2 Ab (L328C)-vcMMAE [481]
TROP2 (L328C)
Tumor-associated calcium signal transducer 2 (TACSTD2)
Monomethyl auristatin E
Mc-Val-Cit-PABC
anti-EGFR Ab No.1 (L234A, L235A, L328C)-vcMMAE [481]
EGFR No.1 (L234A, L235A, L328C)
Epidermal growth factor receptor (EGFR)
Monomethyl auristatin E
Mc-Val-Cit-PABC
anti-EGFR Ab No.3 (L234A, L235A, L328C)-vcMMAE [481]
EGFR No.3 (L234A, L235A, L328C)
Epidermal growth factor receptor (EGFR)
Monomethyl auristatin E
Mc-Val-Cit-PABC
LOL1-anti-HER2 Ab (L234A, L235A, L328C) [481]
LOL1-HER2 (L234A, L235A, L328C)
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
Mc-Val-Cit-PABC
anti-TROP2 Ab (L234A, L235A, L328C)-vcMMAE [481]
TROP2 Ab (L234A, L235A, L328C)
Tumor-associated calcium signal transducer 2 (TACSTD2)
Monomethyl auristatin E
Mc-Val-Cit-PABC
EP4470568A1 ADC-3 [482]
hAb017-10
B-cell antigen receptor complex-associated protein beta chain (CD79B)
Monomethyl auristatin E
Mc-Val-Cit-PABC
EP4470568A1 ADC-5 [482]
hAb015-10
B-cell antigen receptor complex-associated protein beta chain (CD79B)
Monomethyl auristatin E
Mc-Val-Cit-PABC
EP4470568A1 ADC-6 [482]
hAb015-10
B-cell antigen receptor complex-associated protein beta chain (CD79B)
Monomethyl auristatin E
Mc-Val-Cit-PABC
EP4470568A1 ADC-7 [482]
hAb015-10
B-cell antigen receptor complex-associated protein beta chain (CD79B)
Monomethyl auristatin E
Mc-Val-Cit-PABC
EP4470568A1 ADC-8 [482]
SN8
B-cell antigen receptor complex-associated protein beta chain (CD79B)
Monomethyl auristatin E
Mc-Val-Cit-PABC
WO2024110905A1 ADC1-2 [483]
Undisclosed
Carcinoembryonic antigen-related cell adhesion molecule 5 (CEACAM5)
Monomethyl auristatin E
Linker of ADC1-2
WO2024110905A1 ADC1-4 [483]
Undisclosed
Carcinoembryonic antigen-related cell adhesion molecule 5 (CEACAM5)
Monomethyl auristatin E
Linker of ADC1-4
WO2024110905A1 ADC1-11 [483]
Undisclosed
Carcinoembryonic antigen-related cell adhesion molecule 5 (CEACAM5)
Monomethyl auristatin E
Linker of ADC1-11
WO2024110905A1 ADC2-2 [483]
Undisclosed
Carcinoembryonic antigen-related cell adhesion molecule 5 (CEACAM5)
Monomethyl auristatin E
Linker of ADC1-2
WO2024110905A1 ADC2-4 [483]
Undisclosed
Carcinoembryonic antigen-related cell adhesion molecule 5 (CEACAM5)
Monomethyl auristatin E
Linker of ADC1-4
WO2024110905A1 ADC2-9-1 [483]
Undisclosed
Carcinoembryonic antigen-related cell adhesion molecule 5 (CEACAM5)
Monomethyl auristatin E
Linker of ADC2-9-1
WO2024110905A1 ADC2-9-2 [483]
Undisclosed
Carcinoembryonic antigen-related cell adhesion molecule 5 (CEACAM5)
Monomethyl auristatin E
Linker of ADC2-9-1
WO2024110905A1 ADC2-11 [483]
Undisclosed
Carcinoembryonic antigen-related cell adhesion molecule 5 (CEACAM5)
Monomethyl auristatin E
Linker of ADC1-11
WO2024110905A1 ADC2-36-1 [483]
Undisclosed
Carcinoembryonic antigen-related cell adhesion molecule 5 (CEACAM5)
Monomethyl auristatin E
Linker of ADC2-36-1
WO2024110905A1 ADC2-36-2 [483]
Undisclosed
Carcinoembryonic antigen-related cell adhesion molecule 5 (CEACAM5)
Monomethyl auristatin E
Linker of ADC2-36-1
WO2024110905A1 ADC2-43 [483]
Undisclosed
Carcinoembryonic antigen-related cell adhesion molecule 5 (CEACAM5)
Monomethyl auristatin E
Linker of ADC2-43
WO2024110905A1 ADC2-62-1 [483]
Undisclosed
Carcinoembryonic antigen-related cell adhesion molecule 5 (CEACAM5)
Monomethyl auristatin E
ADC2-62-1 Linker
WO2024110905A1 ADC2-62-2 [483]
Undisclosed
Carcinoembryonic antigen-related cell adhesion molecule 5 (CEACAM5)
Monomethyl auristatin E
ADC2-62-1 Linker
WO2024110905A1 ADC2-63-1 [483]
Undisclosed
Carcinoembryonic antigen-related cell adhesion molecule 5 (CEACAM5)
Monomethyl auristatin E
ADC2-63-1 Linker
WO2024110905A1 ADC2-63-2 [483]
Undisclosed
Carcinoembryonic antigen-related cell adhesion molecule 5 (CEACAM5)
Monomethyl auristatin E
ADC2-63-1 Linker
WO2024110905A1 ADC2-64-1 [483]
Undisclosed
Carcinoembryonic antigen-related cell adhesion molecule 5 (CEACAM5)
Monomethyl auristatin E
ADC2-64-1 Linker
WO2024110905A1 ADC2-64-2 [483]
Undisclosed
Carcinoembryonic antigen-related cell adhesion molecule 5 (CEACAM5)
Monomethyl auristatin E
ADC2-64-1 Linker
WO2024110905A1 ADC2-65-1 [483]
Undisclosed
Carcinoembryonic antigen-related cell adhesion molecule 5 (CEACAM5)
Monomethyl auristatin E
ADC2-62-1 Linker
WO2024110905A1 ADC2-65-2 [483]
Undisclosed
Carcinoembryonic antigen-related cell adhesion molecule 5 (CEACAM5)
Monomethyl auristatin E
ADC2-64-1 Linker
YC1605 [484]
J591
Glutamate carboxypeptidase 2 (FOLH1)
Monomethyl auristatin E
Mc-Val-Cit-PABC
WO2024105206A1 33i-5657 2 [485]
TPP-5657
Undisclosed
Monomethyl auristatin E
22i-5657 Linker
WO2024105206A1 34p-Avelu 2 [485]
TPP-Avelumab
Programmed cell death 1 ligand 1 (PD-L1)
Monomethyl auristatin E
22i-5657 Linker
anti-TRBC1-MMAE [486]
Undisclosed
T cell receptor beta-chain constant region 1 (TRBC1)
Monomethyl auristatin E
Mc-Val-Cit-PABC
AU2023281032A1 ADC-1 [487]
Undisclosed
Undisclosed
Monomethyl auristatin E
AU2023281032A1 ADC-1 linker
AU2023281032A1 ADC-5 [487]
anti-TROP2 antibody
Tumor-associated calcium signal transducer 2 (TACSTD2)
Monomethyl auristatin E
AU2023281032A1 ADC-1 linker
C1.18 DBM- (C6)-MMAF [488]
C1.18
V-type immunoglobulin domain-containing suppressor of T-cell activation (VSIR)
Monomethyl auristatin F
DBM linker
CN114230664B 146C: DBM- (C6)-MMAF [488]
146C:
V-type immunoglobulin domain-containing suppressor of T-cell activation (VSIR)
Monomethyl auristatin F
DBM linker
CN114230664B 164A: DBM- (C6)-MMAF [488]
164A
V-type immunoglobulin domain-containing suppressor of T-cell activation (VSIR)
Monomethyl auristatin F
DBM linker
CN114230664B 208A: DBM- (C6)-MMAF [488]
208A
V-type immunoglobulin domain-containing suppressor of T-cell activation (VSIR)
Monomethyl auristatin F
DBM linker
CN114230664B 215A: DBM- (C6)-MMAF [488]
215A
V-type immunoglobulin domain-containing suppressor of T-cell activation (VSIR)
Monomethyl auristatin F
DBM linker
CN114230664B 230A: DBM- (C6)-MMAF [488]
230A
V-type immunoglobulin domain-containing suppressor of T-cell activation (VSIR)
Monomethyl auristatin F
DBM linker
CN114230664B 259A: DBM- (C6)-MMAF [488]
259A
V-type immunoglobulin domain-containing suppressor of T-cell activation (VSIR)
Monomethyl auristatin F
DBM linker
CN114230664B 305A: DBM- (C6)-MMAF [488]
305A
V-type immunoglobulin domain-containing suppressor of T-cell activation (VSIR)
Monomethyl auristatin F
DBM linker
CN114230664B 353A: DBM- (C6)-MMAF [488]
353A
V-type immunoglobulin domain-containing suppressor of T-cell activation (VSIR)
Monomethyl auristatin F
DBM linker
CN114230664B 53A: DBM- (C6)-MMAF [488]
53A
V-type immunoglobulin domain-containing suppressor of T-cell activation (VSIR)
Monomethyl auristatin F
DBM linker
CN114230664B 5B: DBM- (C6)-MMAF [488]
5B
V-type immunoglobulin domain-containing suppressor of T-cell activation (VSIR)
Monomethyl auristatin F
DBM linker
CN114230664B 175A: DBM- (C6)-MMAF [488]
175A
V-type immunoglobulin domain-containing suppressor of T-cell activation (VSIR)
Monomethyl auristatin F
DBM linker
CN114230664B 76E1: DBM- (C6)-MMAF [488]
760
V-type immunoglobulin domain-containing suppressor of T-cell activation (VSIR)
Monomethyl auristatin F
DBM linker
mAb1-MMAE [489]
mAb1
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
Mc-Val-Cit-PABC
mAb2-MMAE [489]
Undisclosed
Undisclosed
Monomethyl auristatin E
Mc-Val-Cit-PABC
mAb3-MMAE [489]
Undisclosed
Undisclosed
Monomethyl auristatin E
Mc-Val-Cit-PABC
mAb4-MMAE [489]
Undisclosed
Undisclosed
Monomethyl auristatin E
Mc-Val-Cit-PABC
mAb5-MMAE [489]
Undisclosed
Undisclosed
Monomethyl auristatin E
Mc-Val-Cit-PABC
mAb6-MMAE [489]
Undisclosed
Undisclosed
Monomethyl auristatin E
Mc-Val-Cit-PABC
mAb7-MMAE [489]
Undisclosed
Undisclosed
Monomethyl auristatin E
Mc-Val-Cit-PABC
mAb8-MMAE [489]
Undisclosed
Undisclosed
Monomethyl auristatin E
Mc-Val-Cit-PABC
mAb9-MMAE [489]
Undisclosed
Undisclosed
Monomethyl auristatin E
Mc-Val-Cit-PABC
mAb10-MMAE [489]
Undisclosed
Undisclosed
Monomethyl auristatin E
Mc-Val-Cit-PABC
mAb11-MMAE [489]
Undisclosed
Undisclosed
Monomethyl auristatin E
Mc-Val-Cit-PABC
mAb12-MMAE [489]
Undisclosed
Undisclosed
Monomethyl auristatin E
Mc-Val-Cit-PABC
mAb13-MMAE [489]
Undisclosed
Undisclosed
Monomethyl auristatin E
Mc-Val-Cit-PABC
mAb14-MMAE [489]
Undisclosed
Undisclosed
Monomethyl auristatin E
Mc-Val-Cit-PABC
mAb15-MMAE [489]
Undisclosed
Undisclosed
Monomethyl auristatin E
Mc-Val-Cit-PABC
mAb16-MMAE [489]
Undisclosed
Undisclosed
Monomethyl auristatin E
Mc-Val-Cit-PABC
mAb17-MMAE [489]
Undisclosed
Undisclosed
Monomethyl auristatin E
Mc-Val-Cit-PABC
mAb18-MMAE [489]
Undisclosed
Undisclosed
Monomethyl auristatin E
Mc-Val-Cit-PABC
mAb1-MMAF [489]
mAb1
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin F
Mc-Val-Cit-PABC
mAb2-MMAF [489]
Undisclosed
Undisclosed
Monomethyl auristatin F
Mc-Val-Cit-PABC
mAb3-MMAF [489]
Undisclosed
Undisclosed
Monomethyl auristatin F
Mc-Val-Cit-PABC
mAb17-MMAF [489]
Undisclosed
Undisclosed
Monomethyl auristatin F
Mc-Val-Cit-PABC
US11903948B2 I-1 [490]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Dolicatatin 5
Undisclosed
CD44-VCMMAE [491]
Undisclosed
CD44 antigen (CD44)
Monomethyl auristatin E
Mc-Val-Cit-PABC
CD44-MMAE [491]
Undisclosed
CD44 antigen (CD44)
Monomethyl auristatin E
CN117362435A+SCD44-MMAE+Linker
CD44-DM1 [491]
Undisclosed
CD44 antigen (CD44)
Mertansine DM1
Succinimidyl-4- (N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
CANO01-MC-MMAF [492]
CANO01
Undisclosed
Monomethyl auristatin F
Maleimidocaproyl (me) linker
LR004-VC-MMAE [493]
LR004
Undisclosed
Monomethyl auristatin E
Mc-Val-Cit-PABC
CN112638426B ADC1 [494]
mil40
Undisclosed
Tubulin inhibitor B
CN112638426B +ADC1+Linker
CN112638426B ADC2 [494]
mil40
Undisclosed
Tubulin inhibitor B
CN112638426B +ADC2+Linker
US11661457B2 Ab-E-12 [495]
IGF-1R
Undisclosed
US11661457B2+Ab-E-12+payload
Mc-Val-Cit-PABC
US11661457B2 Ab-G-12 [495]
IGF-1R
Undisclosed
US11661457B2+Ab-E-12+payload
6-Maleimidocaproic acid
WO2024099368A1 Tra-CAST-MMAE [496]
Undisclosed
Undisclosed
Monomethyl auristatin E
WO2024099368A1+Tra-CAST-MMAE+Linker
DBCO-vc-MMAE [497]
HuSS1
Undisclosed
Monomethyl auristatin E
EP4161582A4+DBCO-vc-MMAE+Linker
DBCO-S-DM1 [497]
HuSS1
Undisclosed
Mertansine DM1
DBCO-PEG3-amine
BCN-PEG3-VC-PAB-MMAE [497]
HuSS1
Undisclosed
Monomethyl auristatin E
EP4161582A4+BCN-PEG3-VC-PAB-MMAE+Linker
DBCO-PEG3-2 (PEG3-VC-PAB-MMAE) [497]
HuSS1
Undisclosed
Monomethyl auristatin E
EP4161582A4+DBCO-PEG3-2 (PEG3-VC-PAB-MMAE)+Linker
IgG2a-Val-Cit-Pab-MMAE [498]
Undisclosed
Undisclosed
Monomethyl auristatin E
WO2024102603A1+lgG2a-Val-Cit-Pab-MMAE+Linker
IgG2a-PEG8-MMAE [498]
Undisclosed
Transmembrane 4 L6 family member 1 (TM4SF1)
Monomethyl auristatin E
WO2024102603A1+lgG2a-PEG8-MMAE+Linker
CN114106088A ADC1 [499]
Undisclosed
Peripheral myelin protein 22 (Pmp22)
Tubulin inhibitor B
CN114106088A+ADC1+Linker
CN114106088A ADC2 [499]
Undisclosed
Peripheral myelin protein 22 (Pmp22)
Tubulin inhibitor B
CN114106088A+ADC2+Linker
CN114106088A ADC3 [499]
Undisclosed
Peripheral myelin protein 22 (Pmp22)
Tubulin inhibitor B
CN114106088A+ADC3+Linker
CN114106088A ADC4 [499]
Undisclosed
Peripheral myelin protein 22 (Pmp22)
Tubulin inhibitor B
CN114106088A+ADC4+Linker
CN114106088A ADC5 [499]
Undisclosed
Peripheral myelin protein 22 (Pmp22)
Tubulin inhibitor B
CN114106088A+ADC5+Linker
CN114106088A ADC6 [499]
Undisclosed
Receptor tyrosine-protein kinase erbB-2 (HER2)
Tubulin inhibitor B
CN114106088A+ADC1+Linker
CN114106088A ADC7 [499]
Undisclosed
Receptor tyrosine-protein kinase erbB-2 (HER2)
Tubulin inhibitor B
CN114106088A+ADC2+Linker
CN114106088A ADC8 [499]
Undisclosed
Receptor tyrosine-protein kinase erbB-2 (HER2)
Tubulin inhibitor B
CN114106088A+ADC3+Linker
CN114106088A ADC9 [499]
Undisclosed
Receptor tyrosine-protein kinase erbB-2 (HER2)
Tubulin inhibitor B
CN114106088A+ADC4+Linker
CN114106088A ADC10 [499]
Undisclosed
Receptor tyrosine-protein kinase erbB-2 (HER2)
Tubulin inhibitor B
CN114106088A+ADC5+Linker
LN401-20-1 [499]
Undisclosed
Peripheral myelin protein 22 (Pmp22)
Tubulin inhibitor B
CN114106088A+ADC1+Linker
LN401-20-2 [499]
Undisclosed
Peripheral myelin protein 22 (Pmp22)
Tubulin inhibitor B
CN114106088A+ADC2+Linker
LN401-89-5 [499]
Undisclosed
Peripheral myelin protein 22 (Pmp22)
Tubulin inhibitor B
CN114106088A+ADC3+Linker
LN401-89-6 [499]
Undisclosed
Peripheral myelin protein 22 (Pmp22)
Tubulin inhibitor B
CN114106088A+ADC4+Linker
LN401-88-5 [499]
Undisclosed
Peripheral myelin protein 22 (Pmp22)
Tubulin inhibitor B
CN114106088A+ADC5+Linker
LN401-31-1 [499]
Undisclosed
Receptor tyrosine-protein kinase erbB-2 (HER2)
Tubulin inhibitor B
CN114106088A+ADC1+Linker
LN401-31-2 [499]
Undisclosed
Receptor tyrosine-protein kinase erbB-2 (HER2)
Tubulin inhibitor B
CN114106088A+ADC2+Linker
LN401-90-5 [499]
Undisclosed
Receptor tyrosine-protein kinase erbB-2 (HER2)
Tubulin inhibitor B
CN114106088A+ADC3+Linker
LN401-90-6 [499]
Undisclosed
Receptor tyrosine-protein kinase erbB-2 (HER2)
Tubulin inhibitor B
CN114106088A+ADC4+Linker
LN401-90-4 [499]
Undisclosed
Receptor tyrosine-protein kinase erbB-2 (HER2)
Tubulin inhibitor B
CN114106088A+ADC5+Linker
KR1020250008730A ADC1 [500]
B62-H3L3
Inactive tyrosine-protein kinase transmembrane receptor ROR1 (ROR1)
Monomethyl auristatin E
Mc-Val-Cit-PABC
KR1020250008730A ADC2 [500]
B31-H3L3
Inactive tyrosine-protein kinase transmembrane receptor ROR1 (ROR1)
Monomethyl auristatin E
Mc-Val-Cit-PABC
KR1020250008730A 99961.1-MMAE [500]
99961.1
Inactive tyrosine-protein kinase transmembrane receptor ROR1 (ROR1)
Monomethyl auristatin E
Mc-Val-Cit-PABC
US20240091372A1 3H9-KGDEVD-MMAE [501]
3H9
Prion-like protein doppel (PRND)
Monomethyl auristatin E
KGDEVD linker
US20240091372A1 3D1-KGDEVD-MMAE [501]
3D1
Interleukin-3 receptor subunit alpha (IL3RA)
Monomethyl auristatin E
KGDEVD linker
US20240091372A1 3D5-KGDEVD-MMAE [501]
3D5
Prion-like protein doppel (PRND)
Monomethyl auristatin E
KGDEVD linker
US20240091372A1 4D1-KGDEVD-MMAE [501]
4D1
Prion-like protein doppel (PRND)
Monomethyl auristatin E
KGDEVD linker
US20240091372A1 3H9-vc-MMAE [501]
3H9
Prion-like protein doppel (PRND)
Monomethyl auristatin E
Mc-Val-Cit-PABC
US20240091372A1 3D1-vc-MMAE [501]
3D1
Interleukin-3 receptor subunit alpha (IL3RA)
Monomethyl auristatin E
Mc-Val-Cit-PABC
US20240091372A1 3D5-vc-MMAE [501]
3D5
Prion-like protein doppel (PRND)
Monomethyl auristatin E
Mc-Val-Cit-PABC
US20240091372A1 4D1-vc-MMAE [501]
4D1
Prion-like protein doppel (PRND)
Monomethyl auristatin E
Mc-Val-Cit-PABC
US20240091372A1 3H9-DEVD-MMAE [501]
3H9
Prion-like protein doppel (PRND)
Monomethyl auristatin E
DEVD linker
F314-MC-VC-PAB-MMAE [502]
F314
Ectonucleoside triphosphate diphosphohydrolase 1 (ENTPD1)
Monomethyl auristatin E
Mc-Val-Cit-PABC
F314-SMCC-DM1 [502]
F314
Ectonucleoside triphosphate diphosphohydrolase 1 (ENTPD1)
Mertansine DM1
Succinimidyl-4- (N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
F314-C4-VC-PAB-MMAE [502]
F314
Ectonucleoside triphosphate diphosphohydrolase 1 (ENTPD1)
Monomethyl auristatin E
C4-VC-PAB
F314-C5-VC-PAB-MMAE-0.8 [502]
F314
Ectonucleoside triphosphate diphosphohydrolase 1 (ENTPD1)
Monomethyl auristatin E
C5-VC-PAB
F314-C5-VC-PAB-MMAE-1.8 [502]
F314
Ectonucleoside triphosphate diphosphohydrolase 1 (ENTPD1)
Monomethyl auristatin E
C5-VC-PAB
F314-C5-VC-PAB-MMAE-2.3 [502]
F314
Ectonucleoside triphosphate diphosphohydrolase 1 (ENTPD1)
Monomethyl auristatin E
C5-VC-PAB
F314-C5-VC-PAB-MMAE-3.0 [502]
F314
Ectonucleoside triphosphate diphosphohydrolase 1 (ENTPD1)
Monomethyl auristatin E
C5-VC-PAB
F314-C6-VC-PAB-MMAE [502]
F314
Ectonucleoside triphosphate diphosphohydrolase 1 (ENTPD1)
Monomethyl auristatin E
C6-VC-PAB
F1-SMCC-DM1 [502]
F1
Ectonucleoside triphosphate diphosphohydrolase 1 (ENTPD1)
Mertansine DM1
Succinimidyl-4- (N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
WO2023232144A1ADC-1 [503]
anti-HER2 antibody mAb-1
Receptor tyrosine-protein kinase erbB-2 (HER2)
WO2023232144A1, ADC-1, Payload
WO2023232144A1, ADC-1, linker
WO2023232144A1ADC-4 [503]
anti-TROP2 antibody mAb-2
Tumor-associated calcium signal transducer 2 (TACSTD2)
WO2023232144A1, ADC-1, Payload
WO2023232144A1, ADC-1, linker
WO2025019776A2ADC 22-2 [504]
A22
Interleukin-13 receptor subunit alpha-2 (IL13RA2)
Monomethyl auristatin E
WO2025019776A2, ADC 22-2, Linker
WO2025019776A2ADC 33-2 [504]
A33
Interleukin-13 receptor subunit alpha-2 (IL13RA2)
Monomethyl auristatin E
WO2025019776A2, ADC 22-2, Linker
WO2025019776A2ADC 52-2 [504]
A52
Interleukin-13 receptor subunit alpha-2 (IL13RA2)
Monomethyl auristatin E
WO2025019776A2, ADC 22-2, Linker
IMGN529 [505]
Naratuximab
Leukocyte antigen CD37 (CD37)
Mertansine DM1
Succinimidyl-4- (N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
AU2023279443A1 Example 2 [506]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
U-031
AU2023279443A1, Example 3, Linker
AU2023279443A1 Example 4 [506]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
U-031
AU2023279443A1, Example 4, Linker
AU2023279443A1 Example 5 [506]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
U-031
AU2023279443A1, Example 5, Linker
AU2023279443A1 Example A1 [506]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
Undisclosed
AU2023279443A1 Example A3 [506]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
U-031
AU2023279443A1, Example A3, Linker
AU2023279443A1 Example A3b [506]
Rituximab
B-lymphocyte antigen CD20 (MS4A1)
U-031
AU2023279443A1, Example A3, Linker
AU2023279443A1 Example A3c [506]
Cetuximab
Epidermal growth factor receptor (EGFR)
U-031
AU2023279443A1, Example A3, Linker
AU2023279443A1 Example A4 [506]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
U-003
Undisclosed
AU2023279443A1 Example A5 [506]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
U-029
Undisclosed
AU2023279443A1 Example A6 [506]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
AU2023279443A1, Example A6, Linker
AU2023279443A1 Example A7 [506]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
AU2023279443A1, Example A7, Linker
AU2023279443A1 Example A8 [506]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
RU20241285-9-linker
AU2023279443A1 Example A9 [506]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
U-036
RU20241285-9-linker
AU2023279443A1 Example A12 [506]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
U-035
AU2023279443A1, Example A12, Linker
AU2023279443A1 Example A14 [506]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Eribulin
RU20241285-9-linker
AU2023279443A1Example A15 [506]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
U-031
AU2023279443A1, Example A15, Linker
AU2023279443A1 Example A16 [506]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Eribulin
AU2023279443A1, Example A16, Linker
AU2023279443A1 Example A17 [506]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Eribulin
AU2023279443A1, Example A17, Linker
AU2023279443A1 Example A18 [506]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Eribulin
AU2023279443A1, Example A18, Linker
AU2023279443A1 Example A19 [506]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
U-031
AU2023279443A1, Example A19, Linker
AU2023279443A1 Example A21 [506]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Eribulin
AU2023279443A1, Example A21, Linker
AU2023279443A1 Example A22 [506]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Eribulin
AU2023279443A1, Example A22, Linker
AU2023279443A1 Comparative Control Compound-1 [506]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
Mc-Val-Cit-PABC
AU2023279443A1 Comparative Control Compound-2 [506]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Eribulin
Mal-PEG2-Val-Cit-PAB
WO2024181570A1 ADC1 [507]
Antibody 1
Syndecan-1 (SDC1)
Mertansine DM1
Succinimidyl-4- (N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
WO2024181570A1 ADC2 [507]
Antibody 2
Syndecan-1 (SDC1)
Mertansine DM4
SPDB
WO2024181570A1 ADC3 [507]
Antibody 1
Syndecan-1 (SDC1)
Monomethyl auristatin E
Mc-Val-Cit-PABC
WO2024181570A1 ADC4 [507]
Antibody 1
Syndecan-1 (SDC1)
Monomethyl auristatin F
Mc-Val-Cit-PABC
WO2024181570A1 ADC8 [507]
Antibody 3
Syndecan-1 (SDC1)
Monomethyl auristatin E
Mc-Val-Cit-PABC
WO2024181570A1 ADC9 [507]
Antibody 4
Syndecan-1 (SDC1)
Monomethyl auristatin E
Mc-Val-Cit-PABC
WO2024181570A1 ADC10 [507]
Antibody 5
Syndecan-1 (SDC1)
Monomethyl auristatin E
Mc-Val-Cit-PABC
WO2024181570A1 ADC11 [507]
Antibody 6
Syndecan-1 (SDC1)
Monomethyl auristatin E
Mc-Val-Cit-PABC
WO2024181570A1 ADC12 [507]
Antibody 10
Syndecan-1 (SDC1)
Monomethyl auristatin E
Mc-Val-Cit-PABC
WO2024181570A1 ADC13 [507]
Antibody 11
Syndecan-1 (SDC1)
Monomethyl auristatin E
Mc-Val-Cit-PABC
WO2024181570A1 ADC14 [507]
Antibody 12
Syndecan-1 (SDC1)
Monomethyl auristatin E
Mc-Val-Cit-PABC
WO2020252015A1 ADCLP-1 [508]
mAb42
Inactive tyrosine-protein kinase transmembrane receptor ROR1 (ROR1)
SC209
DBCO-SO3-PEG4-Val-Cit-PABC
WO2020252015A1 ADCLP-11 [508]
mAb42
Inactive tyrosine-protein kinase transmembrane receptor ROR1 (ROR1)
Monomethyl auristatin E
DBCO-SO3-PEG4-Val-Cit-PABC
WO2020252015A1 ADCLP-12 [508]
mAb42
Inactive tyrosine-protein kinase transmembrane receptor ROR1 (ROR1)
SC209
DBCO sidechain PEG12 ValLys-pAB
WO2020252015A1 ADCLP-13 [508]
mAb42
Inactive tyrosine-protein kinase transmembrane receptor ROR1 (ROR1)
SC209
DBCO SIDECHAIN PEG12-PAB
WO2020252015A1 ADCLP-21 [508]
mAb42
Inactive tyrosine-protein kinase transmembrane receptor ROR1 (ROR1)
SC209
DBCO-nAA-PEG13-VKG
WO2020252015A1 ADCLP-22 [508]
mAb42
Inactive tyrosine-protein kinase transmembrane receptor ROR1 (ROR1)
SC209
DBCO-AA-PEG13-AAN
WO2020252015A1 ADCLP-23 [508]
mAb42
Inactive tyrosine-protein kinase transmembrane receptor ROR1 (ROR1)
SC209
DBCO-6.4nnAA-B-Glucuronide-PEG12
Anti-HER-MC-VC-FABC-MMAE [509]
Anti-Her2 WT
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
Aminooxy-Cys linker
AntiHER-AO-Cys-MC-VC-FABC-MMAE [509]
Anti-Her2 WT
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
Aminooxy-Cys linker
Anti FAF BI1-MC-VC-FABC-MMAE [509]
Anti-FAF B11
Fibroblast growth factor (FGF)
Monomethyl auristatin E
Aminooxy-Cys linker
Anti FAF B11-AO-Cys-MC-VC-FABC-MMAE [509]
Anti-FAF B11
Fibroblast growth factor (FGF)
Monomethyl auristatin E
Aminooxy-Cys linker
SWY2110-VC-MMAE ADC [510]
SWY2110
Epidermal growth factor receptor (EGFR)
Monomethyl auristatin E
Mc-Val-Cit-PABC
VH4Vk3-MC-VCP-MMAE ADC [511]
VH4Vk3
Ephrin type-A receptor 5 (EPHA5)
Monomethyl auristatin E
MC-VCP linker
VH4Vk3-ThioBridge-VCP-MMAE ADC [511]
VH4Vk3
Ephrin type-A receptor 5 (EPHA5)
Monomethyl auristatin E
ThioBridge®-VCP linker
AbT-EXP9 [512]
AbT
Bacterial transglutaminase (BTG)
Monomethyl auristatin E
CN116137818A-AbT-EXP9-linker
AbT-EXP10 [512]
AbT
Bacterial transglutaminase (BTG)
Monomethyl auristatin E
CN116137818A-AbT-EXP10-linker
AbT-EXP11 [512]
AbT
Bacterial transglutaminase (BTG)
Monomethyl auristatin E
CN116137818A-AbT-EXP11-linker
AbT-EXP12 [512]
AbT
Bacterial transglutaminase (BTG)
Monomethyl auristatin E
CN116137818A-AbT-EXP12-linker
mAb-P5 (PEG12)- VC-PAB-MMAE [513]
AV-25
N-myc downstream-regulated gene 2B (NDRG2B)
Monomethyl auristatin E
P5 (PEG12)- VC-PAB linker
mAb-P5 (PEG24)- VC-PAB-MMAE [513]
AV-25
N-myc downstream-regulated gene 2B (NDRG2B)
Monomethyl auristatin E
P5 (PEG24)- VC-PAB linker
mAb-P5 (PEG2)- VC-PAB-MMAE [513]
AV-25
N-myc downstream-regulated gene 2B (NDRG2B)
Monomethyl auristatin E
P5 (PEG2)- VC-PAB linker
mAb-P5 (PEG12)-VA-PAB-MMAE [513]
AV-25
N-myc downstream-regulated gene 2B (NDRG2B)
Monomethyl auristatin E
P5 (PEG12)-VA-PAB linker
mAb-P5 (PEG2)-VA-PAB-MMAE [513]
AV-25
N-myc downstream-regulated gene 2B (NDRG2B)
Monomethyl auristatin E
P5 (PEG2)-VA-PAB linker
mAb-P5 (PEG24)-VA-PAB-MMAE [513]
AV-25
N-myc downstream-regulated gene 2B (NDRG2B)
Monomethyl auristatin E
P5 (PEG24)-VA-PAB linker
IgG-DM1 [514]
Undisclosed
Intercellular adhesion molecule 1 (ICAM1)
Mertansine DM1
Succinimidyl-4- (N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
ICAM1-DM1 1-10 [514]
Undisclosed
Intercellular adhesion molecule 1 (ICAM1)
Mertansine DM1
Succinimidyl-4- (N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
IgG-MMAE 1-10 [514]
Undisclosed
Intercellular adhesion molecule 1 (ICAM1)
Monomethyl auristatin E
Mc-Val-Cit-PABC
ICAM1-MMAE 1-10 [514]
Undisclosed
Intercellular adhesion molecule 1 (ICAM1)
Monomethyl auristatin E
Mc-Val-Cit-PABC
IgG-MMAF [514]
Undisclosed
Intercellular adhesion molecule 1 (ICAM1)
Monomethyl auristatin F
6-Maleimidocaproic acid
ICAM1-MMAF 1-10 [514]
Undisclosed
Intercellular adhesion molecule 1 (ICAM1)
Monomethyl auristatin F
6-Maleimidocaproic acid
CN106714844B ADC-141 [515]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Mertansine DM1
Succinimidyl-4- (N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
ZHER2-Gly3-VC-PAB-MMAF [516]
ZHER2
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin F
Gly3-VC-PAB
ZHER2-Gly3-VC-PAB-MMAE [516]
ZHER2
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
Gly3-VC-PAB
CN113286618A ADC-3 [517]
alpha-HMGB1Ab
High mobility group box 1 protein (HMGB1)
Mertansine DM1
CN113286618A-ADC-3-linker
CN113286618A ADC-4 [517]
alpha-KLHAb
Hemocyanin 1 (KLH1)
Mertansine DM1
Undisclosed
huM25-vcMMAE ADCs [518]
huM25
Leucine-rich repeat-containing protein 15 (LRRC15)
Monomethyl auristatin E
Mc-Val-Cit-PABC
Anti-huLRRC15 ADCs [518]
huM25
Leucine-rich repeat-containing protein 15 (LRRC15)
Monomethyl auristatin F
6-Maleimidocaproic acid
CN114306633A A-1 [519]
pertuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
CN114306633A-A-1-linker
CN114306633A C-3 [519]
pertuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
CN114306633A-C-3-linker
CN110974975B C-00 [520]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
CN110974975B-C-00-linker
SCT-200-M-1 [521]
SCT-200
Epidermal growth factor receptor (EGFR)
Monomethyl auristatin E
CN112604004B-SCT-200-M-1-linker
SCT-200-M-2 [521]
SCT-200
Epidermal growth factor receptor (EGFR)
Monomethyl auristatin E
CN112604004B-SCT-200-M-2-linker
SCT-200-M-3 [521]
SCT-200
Epidermal growth factor receptor (EGFR)
Monomethyl auristatin E
CN112604004B-SCT-200-M-3-linker
SCT-200-C-1 [521]
SCT-200
Epidermal growth factor receptor (EGFR)
Monomethyl auristatin E
CN112604004B-SCT-200-C-1-linker
SCT-200-C-2 [521]
SCT-200
Epidermal growth factor receptor (EGFR)
Monomethyl auristatin E
CN112604004B-SCT-200-C-2-linker
SCT-200-C-3 [521]
SCT-200
Epidermal growth factor receptor (EGFR)
Monomethyl auristatin E
CN112604004B-SCT-200-C-3-linker
SCT-200-C-4 [521]
SCT-200
Epidermal growth factor receptor (EGFR)
Monomethyl auristatin E
CN112604004B-SCT-200-C-4-linker
SCT-200-C-5 [521]
SCT-200
Epidermal growth factor receptor (EGFR)
Monomethyl auristatin E
CN112604004B-SCT-200-C-5-linker
SCT-200-R-1 [521]
SCT-200
Epidermal growth factor receptor (EGFR)
Monomethyl auristatin E
CN112604004B-SCT-200-R-1-linker
SCT-200-R-2 [521]
SCT-200
Epidermal growth factor receptor (EGFR)
Monomethyl auristatin E
CN112604004B-SCT-200-R-2-linker
(RC48-vc-MMAE) [522]
RC48
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
Mc-Val-Ala-PABC
PCAD-mab2-L4-P1 [523]
PCAD-mab2
Cadherin-3 (CDH3)
L4P1 payload
L4-P1 linker
PCAD-mab2-L6-P1 [523]
PCAD-mab2
Cadherin-3 (CDH3)
L4P1 payload
L6-P1 linker
IgG-L4-P1 [523]
Undisclosed
Cadherin-3 (CDH3)
L4P1 payload
L4-P1 linker
IgG-L6-P1 [523]
Undisclosed
Cadherin-3 (CDH3)
L4P1 payload
L6-P1 linker
TW202506738A C-332 [524]
Undisclosed
Undisclosed
TW202506738A-C-332-PAYLOAD
TW202506738A-C-327-LINKER
TW202506738A C-333 [524]
Undisclosed
Undisclosed
TW202506738A-C-332-PAYLOAD
TW202506738A-C-333-LINKER
TW202506738A C-334 [524]
Undisclosed
Undisclosed
TW202506738A-C-332-PAYLOAD
TW202506738A-C-333-LINKER
TW202506738A C-335 [524]
Undisclosed
Undisclosed
TW202506738A-C-332-PAYLOAD
TW202506738A-C-335-LINKER
CN113874046B ADC-1 [525]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
CN113874046B-ADC-1-LINKER
CN113874046B ADC-4 [525]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
CN113874046B-ADC-4-LINKER
CN113874046B ADC-7 [525]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
CN113874046B-ADC-7-LINKER
AZO-ADC-0 [526]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
Solubilizing group-PEG0-Hypoxia sensitive linker-Azobenzene
AZO-ADC-2 [526]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
Solubilizing group-PEG2-Hypoxia sensitive linker-Azobenzene
AZO-ADC-4 [526]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
Solubilizing group-PEG4-Hypoxia sensitive linker-Azobenzene
AZO-ADC-6 [526]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
Solubilizing group-PEG6-Hypoxia sensitive linker-Azobenzene
AZO-ADC-8 [526]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
Solubilizing group-PEG8-Hypoxia sensitive linker-Azobenzene
Trastuzumab-BUPY-DM1 [527]
Trastuzumab-BUPY
Receptor tyrosine-protein kinase erbB-2 (HER2)
Mertansine DM1
N3-SMCC
IgG (8)-m- (b-PEG12)-VC-MMAE [528]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
IgG (8)-m- (b-PEG12)-VC-MMAE
Mb (4)-m- (b-PEG12)-VC-MMAE [528]
Minibody (4 cys)
Receptor tyrosine-protein kinase erbB-2 (HER2)
Monomethyl auristatin E
IgG (8)-m- (b-PEG12)-VC-MMAE
NAPC-ADC [529]
sibrotuzumab
Prolyl endopeptidase FAP (FAP)
Monomethyl auristatin E
MC-Radiation-responsive linker
ALE.P02
Anti-CLDN1 antibody
Claudin-1 (CLDN1)
Monomethyl auristatin E
Mc-Val-Cit-PABC
SYS6005
Anti-ROR1 Fc-silenced mAb
Inactive tyrosine-protein kinase transmembrane receptor ROR1 (ROR1)
Monomethyl auristatin E
A cleavable linker
DXC-008
Anti-PSMA/STEAP1 dual-target antibody
Glutamate carboxypeptidase 2 (FOLH1); Metalloreductase STEAP1 (STEAP1)
Tubulysin B analog
A cleavable linker
Debio 1562M
Naratuximab
Leukocyte antigen CD37 (CD37)
DM1
MultilinkTM Cleavable Linker
HY0001a
HY0001
CUB domain-containing protein 1 (CDCP1)
Monomethyl auristatin E
A cleavable linker
HDM2005
Anti-ROR1 antibody
Inactive tyrosine-protein kinase transmembrane receptor ROR1 (ROR1)
Monomethyl auristatin E
Mc-Val-Cit-PABC
MRG004A
MAB804
Tissue factor (F3)
Monomethyl auristatin E
BCN-Val-Cit linker
laventatug tivedotin
Laventatug
Zinc transporter ZIP6 (SLC39A6)
Monomethyl auristatin E
BrAc-Val-Cit-PABC
VBC101-F11
Anti-EGFR/c-Met bsAb
Hepatocyte growth factor receptor (MET); Epidermal growth factor receptor (EGFR)
Monomethyl auristatin E
Undisclosed
PF-08046054
Undisclosed
Programmed cell death 1 ligand 1 (PD-L1)
Monomethyl auristatin E
Mc-Val-Cit-PABC
WEF-001
Undisclosed
Undisclosed
Monomethyl auristatin E
Undisclosed
PF-08052667
Anti-ITGB6 mAb
Integrin beta-6 (ITGB6)
Monomethyl auristatin E
Mal PEG12 based β-glucuronide linker
BL-M24D1
Undisclosed
Undisclosed
WA-00
Undisclosed
HX111
Anti-OX40 antibody
Tumor necrosis factor receptor superfamily member 4
Monomethyl auristatin E
Mc-Val-Cit-PABC
sacituzumab vedotin
Sacituzumab
Tumor-associated calcium signal transducer 2 (TACSTD2)
Monomethyl auristatin E
Mc-Val-Cit-PABC
SG2918
Anti-LILRB4 mAb
Leukocyte immunoglobulin-like receptor subfamily B member 4
Monomethyl auristatin E
A cleavable linker
CKD-703
Anti-c-Met antibody
Hepatocyte growth factor receptor (MET)
Monomethyl auristatin E
Undisclosed
ARX305
Anti-CD70 mAb
CD70 antigen (CD70)
Amberstatin 269 (AS269)
Oxime-PEG3
JNJ-95298177
Anti-PSMA IgG1k mAb
Glutamate carboxypeptidase 2 (FOLH1)
Amberstatin 269 (AS269)
Oxime-PEG3
AVID100
MAB100
Epidermal growth factor receptor (EGFR)
DM1
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
AGS-16M8F
Anti-ENPP3 antibody
Ectonucleotide pyrophosphatase/phosphodiesterase family member 3 (ENPP3)
Monomethyl auristatin F
Maleimido-caproyl
MBRC-101
Anti-EphA5 mAb
Ephrin type-A receptor 5 (EPHA5)
Monomethyl auristatin E
ThioBridge bis-sulfone Val-Cit linker
NC18
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
AF-HEA
PHF polymer linker
MHB118C
Anti-IGF-1R antibody
Insulin-like growth factor 1 receptor (IGF1R)
Undisclosed
Undisclosed
LY203725
KS1/4
Undisclosed
4-desacetylvinblastine (DAVLB)
A cleavable linker
LY256787
KS1/4
Undisclosed
4-desacetylvinblastine (DAVLB)
A cleavable linker
References
Ref 1 Immunoconjugates targeting cd138 and uses thereof; 2009-07-02.
Ref 2 Development of a Novel CLDN18.2-directed Monoclonal Antibody and Antibody-Drug Conjugate for Treatment of CLDN18.2-Positive Cancers
Ref 3 Introduction to basic information on ADC drug trastuzumab vedotin.
Ref 4 FDA Approval Summary: Polatuzumab Vedotin in the First-Line Treatment of Select Large B-Cell Lymphomas
Ref 5 Trastuzumab emtansine: first global approval
Ref 6 Tisotumab Vedotin: First Approval
Ref 7 Mirvetuximab Soravtansine: First Approval
Ref 8 FDA Approval Summary: Enfortumab Vedotin for Locally Advanced or Metastatic Urothelial Carcinoma
Ref 9 Belantamab Mafodotin: First Approval
Ref 10 [Relation between goiter endemia and iodine content of the drinking water in some zones of Piedmont and Sardinia]
Ref 11 89Zr-MMOT PET Imaging in Pancreatic and Ovarian Cancer Patients
Ref 12 Cirmtuzumab Vedotin (UC-961ADC3), An Anti-ROR1-Monomethyl Auristatin E Antibody-Drug Conjugate, Is a Potential Treatment For ROR1-Positive Leukemia and Solid Tumors. Blood (2013) 122 (21): 1637.
Ref 13 IMGN853, a Folate Receptor- (FR)-Targeting Antibody-Drug Conjugate, Exhibits Potent Targeted Antitumor Activity against FR-Expressing Tumors. Mol Cancer Ther. 2015 Jul;14(7):1605-13.
Ref 14 Introduction to basic information on ADC drug anti-FR (clone M9346A)-SPDB-DM4.
Ref 15 Treating Tissue Factor-Positive Cancers with Antibody-Drug Conjugates That Do Not Affect Blood Clotting. Mol Cancer Ther. 2018 Nov;17(11):2412-2426.
Ref 16 Anti-Extra Domain B Splice Variant of Fibronectin Antibody-Drug Conjugate Eliminates Tumors with Enhanced Efficacy When Combined with Checkpoint Blockade. Mol Cancer Ther. 2022 Sep 6;21(9):1462-1472.
Ref 17 Targeting a Tumor-Specific Epitope on Podocalyxin Increases Survival in Human Tumor Preclinical Models. Front Oncol. 2022 May 4;12:856424.
Ref 18 High-throughput membrane-anchored proteome screening reveals PIEZO1 as a promising antibody-drug target for human esophageal squamous cell carcinoma. Cancer Med. 2022 Oct;11(19):3700-3713.
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Ref 21 Lipolysis-stimulated lipoprotein receptor-targeted antibody-drug conjugate demonstrates potent antitumor activity against epithelial ovarian cancer. Neoplasia. 2023 Jan;35:100853.
Ref 22 Leucine-rich alpha-2-glycoprotein 1 (LRG1) as a novel ADC target. RSC Chem Biol. 2021 May 31;2(4):1206-1220.
Ref 23 An auristatin-based peptide-drug conjugate targeting Kita-Kyushu lung cancer antigen 1 for precision chemoradiotherapy in gastric cancer. Eur J Med Chem. 2022 Nov 5;241:114617.
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Ref 28 Targeting HER2 Expressing Tumors with a Potent Drug Conjugate Based on an Albumin Binding Domain-Derived Affinity Protein. Pharmaceutics. 2021 Nov 3;13(11):1847.
Ref 29 Development of ASG-15ME, a Novel Antibody-Drug Conjugate Targeting SLITRK6, a New Urothelial Cancer Biomarker. Mol Cancer Ther. 2016 Jun;15(6):1301-10.
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Ref 32 Anti-Glypican-1 Antibody-drug Conjugate as Potential Therapy Against Tumor Cells and Tumor Vasculature for Glypican-1-Positive Cholangiocarcinoma. Mol Cancer Ther. 2021 Sep;20(9):1713-1722. doi: 10.1158/1535-7163.MCT-21-0015. Epub 2021 Jun 17.
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Ref 35 Discovery and Optimization of HKT288, a Cadherin-6-Targeting ADC for the Treatment of Ovarian and Renal Cancers. Cancer Discov. 2017 Sep;7(9):1030-1045.
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Ref 38 Protease-activated drug development. Theranostics. 2012;2(2):156-78.
Ref 39 The monoclonal antibody nBT062 conjugated to cytotoxic Maytansinoids has selective cytotoxicity against CD138-positive multiple myeloma cells in vitro and in vivo. Clin Cancer Res. 2009 Jun 15;15(12):4028-37.
Ref 40 Cytotoxic activity of the maytansinoid immunoconjugate B-B4-DM1 against CD138+ multiple myeloma cells. Blood. 2004 Dec 1;104(12):3688-96.
Ref 41 AXL antibody and AXL-ADC mediate antitumor efficacy via targeting AXL in tumor-intrinsic epithelial-mesenchymal transition and tumor-associated M2-like macrophage. Acta Pharmacol Sin. 2023 Jun;44(6):1290-1303.
Ref 42 Cooperative targeting of melanoma heterogeneity with an AXL antibody-drug conjugate and BRAF/MEK inhibitors. Nat Med. 2018 Feb;24(2):203-212.
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Ref 45 Compact hydrophilic electrophiles enable highly efficacious high DAR ADCs with excellent in vivo PK profile. Chem Sci. 2023 Jan 3;14(9):2259-2266. doi: 10.1039/d2sc05678j. eCollection 2023 Mar 1.
Ref 46 A new immunochemical strategy for triple-negative breast cancer therapy. Sci Rep. 2021 Jul 21;11(1):14875.
Ref 47 Development of bifunctional anti-PD-L1 antibody MMAE conjugate with cytotoxicity and immunostimulation. Bioorg Chem. 2021 Nov;116:105366.
Ref 48 Cyclopentadiene as a Multifunctional Reagent for Normal- and Inverse-Electron Demand Diels-Alder Bioconjugation. Bioconjug Chem. 2022 Sep 21;33(9):1609-1619.
Ref 49 Synthesis and Evaluation of Three Azide-Modified Disaccharide Oxazolines as Enzyme Substrates for Single-Step Fc Glycan-Mediated Antibody-Drug Conjugation. Bioconjug Chem. 2022 Jun 15;33(6):1179-1191.
Ref 50 General and Robust Chemoenzymatic Method for Glycan-Mediated Site-Specific Labeling and Conjugation of Antibodies: Facile Synthesis of Homogeneous Antibody-Drug Conjugates. ACS Chem Biol. 2021 Nov 19;16(11):2502-2514.
Ref 51 Sculpting a Uniquely Reactive Cysteine Residue for Site-Specific Antibody Conjugation. Bioconjug Chem. 2022 Jun 15;33(6):1192-1200.
Ref 52 EGFR binding Fc domain-drug conjugates: stable and highly potent cytotoxic molecules mediate selective cell killing. Biol Chem. 2021 Sep 20;403(5-6):525-534.
Ref 53 A FZD7-specific Antibody-Drug Conjugate Induces Ovarian Tumor Regression in Preclinical Models. Mol Cancer Ther. 2022 Jan;21(1):113-124.
Ref 54 Drug Conjugation via Maleimide-Thiol Chemistry Does Not Affect Targeting Properties of Cysteine-Containing Anti-FGFR1 Peptibodies. Mol Pharm. 2022 May 2;19(5):1422-1433.
Ref 55 Antibody drug conjugates, targeting cancer-expressed EGFR, exhibit potent and specific antitumor activity. Biomed Pharmacother. 2023 Jan;157:114047.
Ref 56 An anti-EGFR antibody-drug conjugate overcomes resistance to HER2-targeted drugs. Cancer Lett. 2023 Feb 1;554:216024.
Ref 57 Radiation Cleaved Drug-Conjugate Linkers Enable Local Payload Release. Bioconjug Chem. 2022 Aug 17;33(8):1474-1484.
Ref 58 The HB22.7 Anti-CD22 Monoclonal Antibody Is an Effective Platform for CD22-Targeted Antibody Drug Conjugates for Treatment of Lymphoma and Acute Lymphoblastic Leukemia. Blood. 2012 ;120(21):-. doi: 10.1182/blood.V120.21.1653.1653.
Ref 59 Anti-tumor efficacy of GMF-1A3, an MMAE-based antibody drug conjugate targeting cell surface cleaved Amphiregulin in breast cancer. Cancer Res (2023) 83 (7_Supplement): 562.
Ref 60 Introduction to basic information on ADC drug IN30705.
Ref 61 Izeltabart tapatansine by MacroGenics for Gastroesophageal (GE) Junction Carcinomas: Likelihood of Approval; 30 May 2023.
Ref 62 Discovery of A Novel EGFR-Targeting Antibody-Drug Conjugate, SHR-A1307, for the Treatment of Solid Tumors Resistant or Refractory to Anti-EGFR Therapies. Mol Cancer Ther. 2019 Jun;18(6):1104-1114. doi: 10.1158/1535-7163.MCT-18-0854.
Ref 63 Preclinical Development of an Anti-CD38 Antibody-Drug Conjugate for Treatment of Hematological Malignancies. Blood. 2019 ;134():-. doi: 10.1182/blood-2019-132062.
Ref 64 Preclinical Development of a Bcma Targeting Antibody-Drug Conjugate with Novel Payload for Multiple Myeloma Therapy. Blood. 2019 ;134():-. doi: 10.1182/blood-2019-132080.
Ref 65 Targeting Vesicular LGALS3BP by an Antibody-Drug Conjugate as Novel Therapeutic Strategy for Neuroblastoma. Cancers (Basel). 2020 Oct 15;12(10):2989. doi: 10.3390/cancers12102989.
Ref 66 RN927C, a Site-Specific Trop-2 Antibody-Drug Conjugate (ADC) with Enhanced Stability, Is Highly Efficacious in Preclinical Solid Tumor Models. Mol Cancer Ther. 2016 Nov;15(11):2698-2708. doi: 10.1158/1535-7163.MCT-16-0431. Epub 2016 Aug 31.
Ref 67 RN765C, a low affinity EGFR antibody drug conjugate with potent anti-tumor activity in preclinical solid tumor models. Oncotarget. 2018 Sep 11;9(71):33446-33458. doi: 10.18632/oncotarget.26002. eCollection 2018 Sep 11.
Ref 68 NOTCH3-targeted antibody drug conjugates regress tumors by inducing apoptosis in receptor cells and through transendocytosis into ligand cells. Cell Rep Med. 2021 May 18;2(5):100279. doi: 10.1016/j.xcrm.2021.100279. eCollection 2021 May 18.
Ref 69 Targeting CLDN18.2 by CD3 Bispecific and ADC Modalities for the Treatments of Gastric and Pancreatic Cancer. Sci Rep. 2019 Jun 10;9(1):8420. doi: 10.1038/s41598-019-44874-0.
Ref 70 Mediapharma product pipeline
Ref 71 FcRL5 as a target of antibody-drug conjugates for the treatment of multiple myeloma. Mol Cancer Ther. 2012 Oct;11(10):2222-32. doi: 10.1158/1535-7163.MCT-12-0087. Epub 2012 Jul 17.
Ref 72 Decoupling stability and release in disulfide bonds with antibody-small molecule conjugates. Chem Sci. 2017 Jan 1;8(1):366-370. doi: 10.1039/c6sc01831a. Epub 2016 Aug 22.
Ref 73 Evaluation of endoglin/CD105 as a tumor vasculature target with antibody drug conjugates. Cancer Res (2018) 78 (13_Supplement): 2900.
Ref 74 Introduction to basic information on ADC drug IMB-101 and IMB-102.
Ref 75 Cybrexa therapeutics product pipeline
Ref 76 Introduction to basic information on ADC drug Oberotatug ravtansine.
Ref 77 Preclinical evaluation of a novel antibody-drug conjugate targeting DR5 for lymphoblastic leukemia therapy. Mol Ther Oncolytics. 2021 Apr 29;21:329-339. doi: 10.1016/j.omto.2021.04.013. eCollection 2021 Jun 25.
Ref 78 Spirea secures more capital to develop nextgeneration ADC cancer therapeutics; 2020
Ref 79 Develop highly specific cell engager constructs with improved function and safety by understanding target-effector cell avidity.
Ref 80 Adcitmer , a new CD56-targeting monomethyl auristatin E-conjugated antibody, is a potential therapeutic approach in Merkel cell carcinoma. Br J Dermatol. 2022 Feb;186(2):295-306. doi: 10.1111/bjd.20770.
Ref 81 Therapeutic Potential of MF-TTZ-MMAE, a Site-Specifically Conjugated Antibody-Drug Conjugate, for the Treatment of HER2-Overexpressing Breast Cancer. Bioconjug Chem. 2022 Feb 16;33(2):418-426. doi: 10.1021/acs.bioconjchem.2c00015. Epub 2022 Feb 1.
Ref 82 Divinylpyrimidine reagents generate antibody-drug conjugates with excellent in vivo efficacy and tolerability. Chem Commun (Camb). 2022 Feb 8;58(12):1962-1965. doi: 10.1039/d1cc06766d.
Ref 83 Monomethyl auristatin E-conjugated anti-EGFR antibody inhibits the growth of human EGFR-positive non-small cell lung cancer. Cancer Chemother Pharmacol. 2019 Jul;84(1):61-72. doi: 10.1007/s00280-019-03848-9. Epub 2019 Apr 29.
Ref 84 MET and RON receptor tyrosine kinases in colorectal adenocarcinoma: molecular features as drug targets and antibody-drug conjugates for therapy. J Exp Clin Cancer Res. 2020 Sep 22;39(1):198. doi: 10.1186/s13046-020-01711-x.
Ref 85 Old target, but new approach: Targeting cancer-associated MUC1 with ADC and Car-T. Cancer Res (2020) 80 (16_Supplement): 6530.
Ref 86 Preclinical characterization of a novel SSEA-4-targeting antibody drug conjugate, OBI-998. Cancer Res (2021) 81 (13_Supplement): 955.
Ref 87 ICOS is widely expressed in cutaneous T-cell lymphoma, and its targeting promotes potent killing of malignant cells. Blood Adv. 2020 Oct 27;4(20):5203-5214. doi: 10.1182/bloodadvances.2020002395.
Ref 88 Tumor stroma-targeted antibody-drug conjugate triggers localized anticancer drug release. J Clin Invest. 2018 Jul 2;128(7):2927-2943. doi: 10.1172/JCI120481. Epub 2018 Jun 4.
Ref 89 Introduction to basic information on ADC drug IMAB362-VCMMAE.
Ref 90 Preclinical characterization of the safety and antitumor activity of IMAB027-vcMMAE, an anticlaudin 6 antibody-drug conjugate. Cancer Res (2018) 78 (13_Supplement): 1778.
Ref 91 Eradicating mesothelin-positive human gastric and pancreatic tumors in xenograft models with optimized anti-mesothelin antibody-drug conjugates from synthetic antibody libraries. Sci Rep. 2021 Jul 29;11(1):15430. doi: 10.1038/s41598-021-94902-1.
Ref 92 Introduction to basic information on ADC drug Bstrongximab ADC (CureMeta).
Ref 93 The cytotoxic conjugate of highly internalizing tetravalent antibody for targeting FGFR1-overproducing cancer cells. Mol Med. 2021 May 7;27(1):46. doi: 10.1186/s10020-021-00306-2.
Ref 94 An antibody-drug conjugate with intracellular drug release properties showing specific cytotoxicity against CD7-positive cells. Leuk Res. 2021 Sep;108:106626. doi: 10.1016/j.leukres.2021.106626.
Ref 95 Therapeutic efficacy of a novel humanized antibody-drug conjugate recognizing plexin-semaphorin-integrin domain in the RON receptor for targeted cancer therapy. J Immunother Cancer. 2019 Sep 13;7(1):250. doi: 10.1186/s40425-019-0732-8.
Ref 96 Introduction to basic information on ADC drug GB-7008-01-vcMMAE.
Ref 97 Development of Cirmtuzumab Antibody-Drug Conjugates (ADCs) Targeting Receptor Tyrosine Kinase-like Orphan Receptor 1 (ROR1). Blood. 2018 ;132():-. doi: 10.1182/blood-2018-99-119447.
Ref 98 Monomethyl auristatin antibody and peptide drug conjugates for trimodal cancer chemo-radio-immunotherapy. Nat Commun. 2022 Jul 5;13(1):3869. doi: 10.1038/s41467-022-31601-z.
Ref 99 Innovative Bioconjugation Technology for Antibody-Drug Conjugates: Proof of Concept in a CD30-Positive Lymphoma Mouse Model. Bioconjug Chem. 2021 Mar 17;32(3):595-606. doi: 10.1021/acs.bioconjchem.1c00058. Epub 2021 Feb 25.
Ref 100 Avibodie are engineered, bivalent antibody fragments, precisely loaded with imaging or cytotoxic payloads
Ref 101 Treatment of ovarian cancer by targeting the tumor stem cell-associated carbohydrate antigen, Sialyl-Thomsen-nouveau. Oncotarget. 2018 May 1;9(33):23289-23305. doi: 10.18632/oncotarget.25289. eCollection 2018 May 1.
Ref 102 Characterization of Site-Specifically Conjugated Monomethyl Auristatin E- and Duocarmycin-Based Anti-PSMA Antibody-Drug Conjugates for Treatment of PSMA-Expressing Tumors. J Nucl Med. 2018 Mar;59(3):494-501. doi: 10.2967/jnumed.117.196279. Epub 2017 Nov 16.
Ref 103 FcRL5 as a target of antibody-drug conjugates for the treatment of multiple myeloma. Mol Cancer Ther. 2012 Oct;11(10):2222-32. doi: 10.1158/1535-7163.MCT-12-0087. Epub 2012 Jul 17.
Ref 104 Development of Novel Quaternary Ammonium Linkers for Antibody-Drug Conjugates. Mol Cancer Ther. 2016 May;15(5):938-45. doi: 10.1158/1535-7163.MCT-16-0038. Epub 2016 Mar 4.
Ref 105 Immunoregulation by IL-7R-targeting antibody-drug conjugates: overcoming steroid-resistance in cancer and autoimmune disease. Sci Rep. 2017 Sep 6;7(1):10735. doi: 10.1038/s41598-017-11255-4.
Ref 106 A multivalent biparatopic EGFR-targeting nanobody drug conjugate displays potent anticancer activity in solid tumor models. Signal Transduct Target Ther. 2021 Sep 3;6(1):320. doi: 10.1038/s41392-021-00666-5.
Ref 107 Targeting a Radiosensitizing Antibody-Drug Conjugate to a Radiation-Inducible Antigen. Clin Cancer Res. 2021 Jun 1;27(11):3224-3233. doi: 10.1158/1078-0432.CCR-20-1725.
Ref 108 Nectin-4: a new prognostic biomarker for efficient therapeutic targeting of primary and metastatic triple-negative breast cancer. Ann Oncol. 2017 Apr 1;28(4):769-776. doi: 10.1093/annonc/mdw678.
Ref 109 Introduction to basic information on ADC drug ST1.
Ref 110 A novel pegylated bispecific antibody-drug conjugate (P-BsADCpb-adc) targeting cancers co-expressing PD-L1 and CD47. Cancer Res (2023) 83 (7_Supplement): 6307.
Ref 111 Antibody-Drug Conjugates Used in Breast Cancers. J Oncol. 2021 Jun 24;2021:9927433. doi: 10.1155/2021/9927433. eCollection 2021.
Ref 112 LCB97, an antibody drug conjugate (ADC) targeting a novel tumor antigen for the treatment of multiple solid tumors. Cancer Res (2023) 83 (7_Supplement): 5653.
Ref 113 Legochem biosciences biopharmaceutical company product pipeline
Ref 114 Anti-Endosialin Antibody-Drug Conjugate: Potential in Sarcoma and Other Malignancies. Mol Cancer Ther. 2015 Sep;14(9):2081-9. doi: 10.1158/1535-7163.MCT-15-0312. Epub 2015 Jul 16.
Ref 115 Anti-NaPi2b antibody-drug conjugate lifastuzumab vedotin (DNIB0600A) compared with pegylated liposomal doxorubicin in patients with platinum-resistant ovarian cancer in a randomized, open-label, phase II study. Ann Oncol. 2018 Apr 1;29(4):917-923.
Ref 116 Introduction to basic information on ADC drug DM003.
Ref 117 Anti-MSLN ADC against cancer; institute of pharmaceutics development center for biotechnology; 2020
Ref 118 A first-in-class anti-HER2/TROP2 bispecific antibody-drug conjugate (YH012) exhibits potent anti-tumor efficacy. Cancer Res (2023) 83 (7_Supplement): 2977.
Ref 119 YH013, a novel EGFR x MET bispecific antibody-drug conjugate, exhibits potent antitumor efficacy. Cancer Res (2023) 83 (7_Supplement): 2978.
Ref 120 Identification of DM004, a first-in-class anti-5T4/MET bispecific antibody-drug conjugate. Cancer Res (2023) 83 (8_Supplement): LB213.
Ref 121 A novel EGFR x MUC1 bispecific antibody-drug conjugate, BSA01, targets MUC1 transmembrane cleavage products and improves tumor selectivity. Cancer Res (2023) 83 (7_Supplement): 6325.
Ref 122 Discovery of BCG033, a novel anti-PTK7 x TROP2 bispecific antibody-drug conjugate with promising efficacy against triple-negative breast cancer. Cancer Res (2023) 83 (8_Supplement): LB216.
Ref 123 BCG022: A novel bispecific antibody-drug conjugate targeting HER3 and MET. Cancer Res (2023) 83 (8_Supplement): LB212.
Ref 124 NextGen conditionally active biologic (CAB) anti-Nectin-4-ADC with improved stability and safety. Cancer Res (2023) 83 (7_Supplement): 1541.
Ref 125 Conditionally active biologics (CAB): A novel class of molecules targeting solid tumors. Cancer Res (2020) 80 (16_Supplement): 4560.
Ref 126 A CD79b Targeting ADC with Superior Anti-Tumor Activity and Safety Resulting in Significantly Improved Therapeutic Index (TI): Safe and Efficacious CD79b ADC. Blood. 2022 ;140():11568-11569. doi: 10.1182/blood-2022-160056.
Ref 127 A clinical candidate anti-mesothelin-MMAE antibody-drug conjugate (ADC) for therapy of mesothelin-expressing cancers. Cancer Res (2014) 74 (19_Supplement): 4494.
Ref 128 Anwita biosciences product pipeline
Ref 129 Preclinical Activity of the Novel Anti-Prolactin Receptor (PRLR) Antibody-Drug Conjugate REGN2878-DM1 in PRLR-Positive Breast Cancers. Mol Cancer Ther. 2017 Jul;16(7):1299-1311. doi: 10.1158/1535-7163.MCT-16-0839. Epub 2017 Apr 4.
Ref 130 A Toxin-Conjugated Recombinant Protein Targeting gp120 and gp41 for Inactivating HIV-1 Virions and Killing Latency-Reversing Agent-Reactivated Latent Cells. mBio. 2022 Feb 22;13(1):e0338421. doi: 10.1128/mbio.03384-21. Epub 2022 Jan 18.
Ref 131 Rational Design and Systemic Appraisal of an EGFR-Targeting Antibody-Drug Conjugate LR-DM1 for Pancreatic Cancer. J Med Chem. 2022 May 26;65(10):7141-7153. doi: 10.1021/acs.jmedchem.1c01920. Epub 2022 May 6.
Ref 132 Humanization of JAA-F11, a Highly Specific Anti-Thomsen-Friedenreich Pancarcinoma Antibody and InVitro Efficacy Analysis. Neoplasia. 2017 Sep;19(9):716-733. doi: 10.1016/j.neo.2017.07.001. Epub 2017 Aug 19.
Ref 133 EphA3 Pay-Loaded Antibody Therapeutics for the Treatment of Glioblastoma. Cancers (Basel). 2018 Dec 17;10(12):519. doi: 10.3390/cancers10120519.
Ref 134 Antibody-drug conjugates targeting CD248(+) myofibroblasts effectively alleviate renal fibrosis in mice. FASEB J. 2022 Feb;36(2):e22102. doi: 10.1096/fj.202101441R.
Ref 135 A Rationally Designed ICAM1 Antibody Drug Conjugate for Pancreatic Cancer. Adv Sci (Weinh). 2020 Nov 3;7(24):2002852. doi: 10.1002/advs.202002852.
Ref 136 A ca6 antigen-specific cytotoxic conjugate and methods of using the same; 2005-02-03
Ref 137 Efficacy of anti-RON antibody Zt/g4-drug maytansinoid conjugation (Anti-RON ADC) as a novel therapeutics for targeted colorectal cancer therapy. Clin Cancer Res. 2014 Dec 1;20(23):6045-58. doi: 10.1158/1078-0432.CCR-14-0898. Epub 2014 Oct 7.
Ref 138 Antibody-Drug Conjugate to Treat Meningiomas. Pharmaceuticals (Basel). 2021 May 2;14(5):427. doi: 10.3390/ph14050427.
Ref 139 A novel ADC targeting cell surface fibromodulin in a mouse model of triple-negative breast cancer. Breast Cancer. 2022 Nov;29(6):1121-1132. doi: 10.1007/s12282-022-01393-7. Epub 2022 Aug 18.
Ref 140 Therapeutic potential of nimotuzumab PEGylated-maytansine antibody drug conjugates against EGFR positive xenograft. Oncotarget. 2019 Feb 1;10(10):1031-1044. doi: 10.18632/oncotarget.26613. eCollection 2019 Feb 1.
Ref 141 Anti-EGFR antibody-drug conjugate for triple-negative breast cancer therapy. Eng Life Sci. 2020 Oct 7;21(1-2):37-44. doi: 10.1002/elsc.202000027. eCollection 2021 Jan.
Ref 142 Anti-CD47 Monoclonal Antibody-Drug Conjugate: A Targeted Therapy to Treat Triple-Negative Breast Cancers. Vaccines (Basel). 2021 Aug 10;9(8):882. doi: 10.3390/vaccines9080882.
Ref 143 Antibody-immunotoxin Conjugate Using FcBP-mediated Photoconjugation to Treat Cancer. Anticancer Res. 2022 Jul;42(7):3453-3461. doi: 10.21873/anticanres.15832.
Ref 144 Bispecific HER2 ADC: Making more potent HER2 ADC by improving target internalization; Cancer Res (2019) 79 (13_Supplement): 233..
Ref 145 Post translational modification therapeutics product pipeline
Ref 146 Antibody drug conjugate using CTAT linker technology shows superior efficacy in xenograft trial; 2015
Ref 147 Introduction to basic information on humanized anti-HER2 mab-maytansine conjugate(Anhui Anke Biotechnology/Wuxi Pharmatech).
Ref 148 Antitumor activity of a 5T4 targeting antibody drug conjugate with a novel payload derived from MMAF via C-Lock linker. Cancer Med. 2019 Apr;8(4):1793-1805. doi: 10.1002/cam4.2066. Epub 2019 Mar 7.
Ref 149 CD70 antibody-drug conjugate as a potential therapeutic agent for uterine leiomyosarcoma. Am J Obstet Gynecol. 2021 Feb;224(2):197.e1-197.e23. doi: 10.1016/j.ajog.2020.08.028. Epub 2020 Aug 19.
Ref 150 N-terminal selective conjugation method widens the therapeutic window of antibody-drug conjugates by improving tolerability and stability. MAbs. 2021 Jan-Dec;13(1):1914885. doi: 10.1080/19420862.2021.1914885.
Ref 151 Antibody targeting of B-cell maturation antigen on malignant plasma cells. Mol Cancer Ther. 2007 Nov;6(11):3009-18. doi: 10.1158/1535-7163.MCT-07-0464.
Ref 152 An Elaborate New Linker System Significantly Enhances the Efficacy of an HER2-Antibody-Drug Conjugate against Refractory HER2-Positive Cancers. Adv Sci (Weinh). 2021 Dec;8(23):e2102414. doi: 10.1002/advs.202102414. Epub 2021 Oct 18.
Ref 153 Site-specific antibody-drug conjugates with variable drug-to-antibody-ratios for AML therapy. J Control Release. 2021 Aug 10;336:433-442. doi: 10.1016/j.jconrel.2021.06.041. Epub 2021 Jun 29.
Ref 154 EV20-mediated delivery of cytotoxic auristatin MMAF exhibits potent therapeutic efficacy in cutaneous melanoma. J Control Release. 2018 May 10;277:48-56. doi: 10.1016/j.jconrel.2018.03.016. Epub 2018 Mar 14.
Ref 155 Antibody-drug conjugate targeting CD46 eliminates multiple myeloma cells. J Clin Invest. 2016 Dec 1;126(12):4640-4653. doi: 10.1172/JCI85856. Epub 2016 Nov 14.
Ref 156 MP-EV20-ADC: humanized anti-HER3 antibody drug conjugate
Ref 157 AVIPEP Therapeutics product pipeline
Ref 158 Preclinical evaluation of NC-6201, an antibody/drug-conjugated micelle incorporating novel hemiasterlin analogue E7974.
Ref 159 Utilization of the Angiopep platform to enable brain penetration of therapeutic mAbs or Antibody-Drug Conjugates for treatment of brain tumors. Cancer Res (2014) 74 (19_Supplement): 2657.
Ref 160 Aphios biotechnology company product pipeline
Ref 161 Compounds, linker-drugs and ligand-drug conjugates; 2020-06-16
Ref 162 Genetically Encoded Azide Containing Amino Acid in Mammalian Cells Enables Site-Specific Antibody-Drug Conjugates Using Click Cycloaddition Chemistry. Bioconjug Chem. 2015 Nov 18;26(11):2249-60. doi: 10.1021/acs.bioconjchem.5b00359.
Ref 163 Dantari biotechnology company product pipeline
Ref 164 Stable and Potent Selenomab-Drug Conjugates. Cell Chem Biol. 2017 Apr 20;24(4):433-442.e6. doi: 10.1016/j.chembiol.2017.02.012.
Ref 165 Trastuzumab-deBouganin Conjugate Overcomes Multiple Mechanisms of T-DM1 Drug Resistance. J Immunother. 2016 Apr;39(3):117-26. doi: 10.1097/CJI.0000000000000115.
Ref 166 Introduction to basic information on eribulin ADC (Jiangsu hengrui)
Ref 167 Preclinical Studies of OBI-999: A Novel Globo H-Targeting Antibody-Drug Conjugate. Mol Cancer Ther. 2021 Jun;20(6):1121-1132.
Ref 168 Coare biopharmaceutical company product pipeline
Ref 169 MI130004, a Novel Antibody-Drug Conjugate Combining Trastuzumab with a Molecule of Marine Origin, Shows Outstanding In Vivo Activity against HER2-Expressing Tumors. Mol Cancer Ther. 2018 Apr;17(4):786-794. doi: 10.1158/1535-7163.MCT-17-0795. Epub 2018 Feb 13.
Ref 170 CD13 as a new tumor target for antibody-drug conjugates: validation with the conjugate MI130110. J Hematol Oncol. 2020 Apr 7;13(1):32. doi: 10.1186/s13045-020-00865-7.
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Ref 172 Antitumor activity of anti-CD30 immunotoxin (Ber-H2/saporin) in vitro and in severe combined immunodeficiency disease mice xenografted with human CD30+ anaplastic large-cell lymphoma. Blood. 1995 Apr 15;85(8):2139-46.
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Ref 177 Bliss Biopharmaceutical company product pipeline
Ref 178 Novel peptide linker-based nectin-4 targeting ADC shows improved tolerability with long-lasting anti-tumor efficacy at low doses. Cancer Res (2023) 83 (8_Supplement): LB221.
Ref 179 Mediapharma product pipeline
Ref 180 The antibody-drug conjugate GENA-111 conjugated to auristatin F shows therapeutic potency in BCAM positive epithelial cancer. 2022.
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Ref 183 Anti-huLRRC15 antibody drug conjugates and methods for their use. 2017-06-08
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Ref 185 A rationally designed ICAM1 antibody drug conjugate eradicates late-stage and refractory triple-negative breast tumors in vivo. Sci Adv. 2023 May 5;9(18):eabq7866. doi: 10.1126/sciadv.abq7866. Epub 2023 May 5.
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Ref 188 AB-3A4: A novel KAAG1-targeting antibody-drug conjugate is active in models of ovarian carcinoma, triple-negative breast cancer and castration-resistant prostate cancer. Cancer Res (2014) 74 (19_Supplement): 666.
Ref 189 Introduction to basic information on ADC drug IGN-786
Ref 190 ADC review AVID-300
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Ref 193 Improving the response to oxaliplatin by targeting chemotherapy-induced CLDN1 in resistant metastatic colorectal cancer cells. Cell Biosci. 2023 Apr 11;13(1):72. doi: 10.1186/s13578-023-01015-5.
Ref 194 Extracellular LGALS3BP: a potential disease marker and actionable target for antibody-drug conjugate therapy in glioblastoma. Mol Oncol. 2023 Aug;17(8):1460-1473. doi: 10.1002/1878-0261.13453. Epub 2023 Jun 7.
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Ref 196 Development of a new minimally invasive phototherapy for lung cancer using antibody-toxin conjugate. Thorac Cancer. 2023 Mar;14(7):645-653. doi: 10.1111/1759-7714.14776. Epub 2023 Jan 19.
Ref 197 Discovery of novel antibody-drug conjugates bearing tissue protease specific linker with both anti-angiogenic and strong cytotoxic effects. Bioorg Chem. 2023 Aug;137:106575. doi: 10.1016/j.bioorg.2023.106575. Epub 2023 Apr 26.
Ref 198 DOG1 as a novel antibody-drug conjugate target for the treatment of multiple gastrointestinal tumors and liver metastasis. Front Immunol. 2023 Jan 26;14:1051506. doi: 10.3389/fimmu.2023.1051506. eCollection 2023.
Ref 199 Endo180 (MRC2) Antibody-Drug Conjugate for the Treatment of Sarcoma. Mol Cancer Ther. 2023 Feb 1;22(2):240-253. doi: 10.1158/1535-7163.MCT-22-0312.
Ref 200 An anti-mesothelin targeting antibody drug conjugate induces pyroptosis and ignites antitumor immunity in mouse models of cancer. J Immunother Cancer. 2023 Mar;11(3):e006274. doi: 10.1136/jitc-2022-006274.
Ref 201 Antibody drug conjugates of cleavable amino-benzoyl-maytansinoids. Bioorg Med Chem. 2020 Dec 1;28(23):115785. doi: 10.1016/j.bmc.2020.115785. Epub 2020 Oct 11.
Ref 202 Antibody-Drug Conjugate Using Ionized Cys-Linker-MMAE as the Potent Payload Shows Optimal Therapeutic Safety. Cancers (Basel). 2020 Mar 21;12(3):744. doi: 10.3390/cancers12030744.
Ref 203 Antibody-Drug Conjugates Using Mouse-Canine Chimeric Anti-Dog Podoplanin Antibody Exerts Antitumor Activity in a Mouse Xenograft Model. Monoclon Antib Immunodiagn Immunother. 2020 Apr;39(2):37-44. doi: 10.1089/mab.2020.0001. Epub 2020 Mar 17.
Ref 204 Anti-glypican-1 antibody-drug conjugate is a potential therapy against pancreatic cancer. Br J Cancer. 2020 Apr;122(9):1333-1341. doi: 10.1038/s41416-020-0781-2. Epub 2020 Mar 10.
Ref 205 Anti-CDCP1 immuno-conjugates for detection and inhibition of ovarian cancer. Theranostics. 2020 Jan 12;10(5):2095-2114. doi: 10.7150/thno.30736. eCollection 2020.
Ref 206 Chemical Artificial Internalizing Receptors for Primary T Cells. Adv Sci (Weinh). 2020 Jul 26;7(18):2001395. doi: 10.1002/advs.202001395. eCollection 2020 Sep.
Ref 207 Antibody-Drug Conjugate that Exhibits Synergistic Cytotoxicity with an Endosome-Disruptive Peptide. ACS Omega. 2019 Jul 31;4(7):12955-12968. doi: 10.1021/acsomega.9b01585. eCollection 2019 Jul 31.
Ref 208 Antibody-Drug Conjugates Targeting the Urokinase Receptor (uPAR) as a Possible Treatment of Aggressive Breast Cancer. Antibodies (Basel). 2019 Nov 5;8(4):54. doi: 10.3390/antib8040054.
Ref 209 Antibody-drug conjugates with HER2-targeting antibodies from synthetic antibody libraries are highly potent against HER2-positive human gastric tumor in xenograft models. MAbs. 2019 Jan;11(1):153-165. doi: 10.1080/19420862.2018.1541370. Epub 2018 Nov 8.
Ref 210 Antibody-Mediated Endocytosis of Polysialic Acid Enables Intracellular Delivery and Cytotoxicity of a Glycan-Directed Antibody-Drug Conjugate. Cancer Res. 2019 Apr 15;79(8):1810-1821. doi: 10.1158/0008-5472.CAN-18-3119. Epub 2019 Feb 26.
Ref 211 Anti-tumor activity of antibody drug conjugate targeting aspartate--hydroxylase in pancreatic ductal adenocarcinoma. Cancer Lett. 2019 May 1;449:87-98. doi: 10.1016/j.canlet.2019.02.006. Epub 2019 Feb 12.
Ref 212 APOMAB Antibody-Drug Conjugates Targeting Dead Tumor Cells are Effective In Vivo. Mol Cancer Ther. 2019 Feb;18(2):335-345. doi: 10.1158/1535-7163.MCT-18-0842. Epub 2018 Nov 9.
Ref 213 Aryl Sulfate is a Useful Motif for Conjugating and Releasing Phenolic Molecules: Sulfur Fluorine Exchange Click Chemistry Enables Discovery of Ortho-Hydroxy-Protected Aryl Sulfate Linker. Bioconjug Chem. 2019 Jul 17;30(7):1957-1968. doi: 10.1021/acs.bioconjchem.9b00340. Epub 2019 Jun 28.
Ref 214 Preclinical Efficacy of Anti-RON Antibody-Drug Conjugate Zt/g4-MMAE for Targeted Therapy of Pancreatic Cancer Overexpressing RON Receptor Tyrosine Kinase. Mol Pharm. 2018 Aug 6;15(8):3260-3271. doi: 10.1021/acs.molpharmaceut.8b00298. Epub 2018 Jun 26.
Ref 215 Preparation and anti-cancer evaluation of promiximab-MMAE, an anti-CD56 antibody drug conjugate, in small cell lung cancer cell line xenograft models. J Drug Target. 2018 Dec;26(10):905-912. doi: 10.1080/1061186X.2018.1450413. Epub 2018 Apr 13.
Ref 216 Antibody drug conjugates of cleavable amino-alkyl and aryl maytansinoids. Bioorg Med Chem. 2018 May 15;26(9):2271-2279. doi: 10.1016/j.bmc.2018.02.025. Epub 2018 Feb 21.
Ref 217 Antibody-nanoparticle conjugate constructed with trastuzumab and nanoparticle albumin-bound paclitaxel for targeted therapy of human epidermal growth factor receptor?2-positive gastric cancer. Oncol Rep. 2018 Mar;39(3):1396-1404. doi: 10.3892/or.2018.6201. Epub 2018 Jan 9.
Ref 218 Anti-glypican-1 antibody-drug conjugate exhibits potent preclinical antitumor activity against glypican-1 positive uterine cervical cancer. Int J Cancer. 2018 Mar 1;142(5):1056-1066. doi: 10.1002/ijc.31124. Epub 2017 Oct 31.
Ref 219 Tumor uptake and associated greater efficacy of anti-Her2 immunoliposome does not rely on Her2 expression status: study of a docetaxel-trastuzumab immunoliposome on Her2+ breast cancer model (SKBR3). Anticancer Drugs. 2020 Jun;31(5):463-472. doi: 10.1097/CAD.0000000000000878.
Ref 220 A Case Study Comparing Heterogeneous Lysine- and Site-Specific Cysteine-Conjugated Maytansinoid Antibody-Drug Conjugates (ADCs) Illustrates the Benefits of Lysine Conjugation. Mol Pharm. 2019 Sep 3;16(9):3926-3937. doi: 10.1021/acs.molpharmaceut.9b00529. Epub 2019 Jul 31.
Ref 221 A coiled-coil masking domain for selective activation of therapeutic antibodies. Nat Biotechnol. 2019 Jul;37(7):761-765. doi: 10.1038/s41587-019-0135-x. Epub 2019 May 27.
Ref 222 A novel antibody-drug conjugate, HcHAb18-DM1, has potent anti-tumor activity against human non-small cell lung cancer. Biochem Biophys Res Commun. 2019 Jun 11;513(4):1083-1091. doi: 10.1016/j.bbrc.2019.04.046. Epub 2019 Apr 19.
Ref 223 Novel b7-h3 binding molecules, antibody drug conjugates thereof and methods of use thereof; 2017-10-19.
Ref 224 Antibody molecules and conjugates; 2023-05-19.
Ref 225 CA6 antigen-specific cytotoxic conjugate and methods of using the same; 2017-11-21.
Ref 226 Anti-integrin immunoconjugates, methods and uses; 2008-01-17.
Ref 227 Folate receptor 1 antibodies and immunoconjugates and uses thereof; 2011-09-01.
Ref 228 Introduction to basic information on ADC drug 1C1-mcMMAF
Ref 229 Compositions and methods related to anti-cd19 antibody drug conjugates; 2017-03-30.
Ref 230 Compositions and methods related to anti-egfr antibody drug conjugates; 2017-03-30.
Ref 231 Antibody-drug conjugate; 2016-08-25.
Ref 232 Tissue factor-targeted antibody-drug conjugate; 2018-03-01.
Ref 233 Anti-claudin 18.2 antibody and antibody-drug conjugate thereof; 2022-11-17.
Ref 234 Antibody-drug conjugates comprising branched linkers and methods related thereto; 2017-06-01.
Ref 235 Antibody-drug conjugate comprising antibody against human ror1, and use for the same; 2021-04-01.
Ref 236 Beta-glucuronide-linker drug conjugates; 2007-10-25.
Ref 237 Methylene carbamate linkers for use with targeted-drug conjugates; 2015-06-25.
Ref 238 Anti-c-met antibody-drug conjugate and applications thereof; 2022-03-10.
Ref 239 Anti-mesothelin antibody and antibody-drug conjugate thereof; 2019-11-28.
Ref 240 Hydrophilic antibody-drug conjugates; 2015-08-20.
Ref 241 Anti-cd228 antibodies and antibody-drug conjugates; 2022-02-10.
Ref 242 A Novel Antibody-Toxin Conjugate to Treat Mantle Cell Lymphoma. Front Oncol. 2019 Apr 10;9:258. doi: 10.3389/fonc.2019.00258. eCollection 2019.
Ref 243 A novel anti-DR5 antibody-drug conjugate possesses a high-potential therapeutic efficacy for leukemia and solid tumors. Theranostics. 2019 Jul 13;9(18):5412-5423. doi: 10.7150/thno.33598. eCollection 2019.
Ref 244 Functional relevance of in vivo half antibody exchange of an IgG4 therapeutic antibody-drug conjugate. PLoS One. 2018 Apr 19;13(4):e0195823. doi: 10.1371/journal.pone.0195823. eCollection 2018.
Ref 245 Generation of high-affinity, internalizing anti-FGFR2 single-chain variable antibody fragment fused with Fc for targeting gastrointestinal cancers. PLoS One. 2018 Feb 8;13(2):e0192194. doi: 10.1371/journal.pone.0192194. eCollection 2018.
Ref 246 Glucuronide-Linked Antibody-Tubulysin Conjugates Display Activity in MDR(+) and Heterogeneous Tumor Models. Mol Cancer Ther. 2018 Aug;17(8):1752-1760. doi: 10.1158/1535-7163.MCT-18-0073. Epub 2018 Jun 4.
Ref 247 Glutamic acid-valine-citrulline linkers ensure stability and efficacy of antibody-drug conjugates in mice. Nat Commun. 2018 Jun 28;9(1):2512. doi: 10.1038/s41467-018-04982-3.
Ref 248 Hydrophilic Auristatin Glycoside Payload Enables Improved Antibody-Drug Conjugate Efficacy and Biocompatibility. Antibodies (Basel). 2018 Mar 22;7(2):15. doi: 10.3390/antib7020015.
Ref 249 Identification and Validation of a Novel Biologics Target in Triple Negative Breast Cancer. Sci Rep. 2019 Oct 17;9(1):14934. doi: 10.1038/s41598-019-51453-w.
Ref 250 Integrin 10, a Novel Therapeutic Target in Glioblastoma, Regulates Cell Migration, Proliferation, and Survival. Cancers (Basel). 2019 Apr 25;11(4):587. doi: 10.3390/cancers11040587.
Ref 251 Novel Silyl Ether-Based Acid-Cleavable Antibody-MMAE Conjugates with Appropriate Stability and Efficacy. Cancers (Basel). 2019 Jul 8;11(7):957. doi: 10.3390/cancers11070957.
Ref 252 Optimal design, anti-tumour efficacy and tolerability of anti-CXCR4 antibody drug conjugates. Sci Rep. 2019 Feb 21;9(1):2443. doi: 10.1038/s41598-019-38745-x.
Ref 253 Activated platelets in the tumor microenvironment for targeting of antibody-drug conjugates to tumors and metastases. Theranostics. 2019 Feb 7;9(4):1154-1169. doi: 10.7150/thno.29146. eCollection 2019.
Ref 254 An auristatin-based antibody-drug conjugate targeting HER3 enhances the radiation response in pancreatic cancer. Int J Cancer. 2019 Oct 1;145(7):1838-1851. doi: 10.1002/ijc.32273. Epub 2019 Apr 1.
Ref 255 Antibody drug conjugates against the receptor for advanced glycation end products (RAGE), a novel therapeutic target in endometrial cancer. J Immunother Cancer. 2019 Oct 29;7(1):280. doi: 10.1186/s40425-019-0765-z.
Ref 256 Impact of cathepsin B-sensitive triggers and hydrophilic linkers on in vitro efficacy of novel site-specific antibody-drug conjugates. Org Biomol Chem. 2018 Mar 14;16(11):1882-1889. doi: 10.1039/c7ob02780j.
Ref 257 Peroxide-cleavable linkers for antibody-drug conjugates. Chem Commun (Camb). 2023 Feb 9;59(13):1841-1844. doi: 10.1039/d2cc06677g.
Ref 258 Balancing Selectivity and Efficacy of Bispecific Epidermal Growth Factor Receptor (EGFR) c-MET Antibodies and Antibody-Drug Conjugates. J Biol Chem. 2016 Nov 25;291(48):25106-25119. doi: 10.1074/jbc.M116.753491. Epub 2016 Sep 30.
Ref 259 ALPPL2 Is a Highly Specific and Targetable Tumor Cell Surface Antigen. Cancer Res. 2020 Oct 15;80(20):4552-4564. doi: 10.1158/0008-5472.CAN-20-1418. Epub 2020 Aug 31.
Ref 260 MORAb-202, an Antibody-Drug Conjugate Utilizing Humanized Anti-human FR Farletuzumab and the Microtubule-targeting Agent Eribulin, has Potent Antitumor Activity. Mol Cancer Ther. 2018 Dec;17(12):2665-2675. doi: 10.1158/1535-7163.MCT-17-1215. Epub 2018 Sep 27.
Ref 261 Incorporation of Hydrophilic Macrocycles Into Drug-Linker Reagents Produces Antibody-Drug Conjugates With Enhanced in vivo Performance. Front Pharmacol. 2022 Jun 17;13:764540. doi: 10.3389/fphar.2022.764540. eCollection 2022.
Ref 262 Therapeutic efficacy of antibody-drug conjugates targeting GD2-positive tumors. J Immunother Cancer. 2022 Jun;10(6):e004646. doi: 10.1136/jitc-2022-004646.
Ref 263 A Novel Family of Acid-Cleavable Linker Based on Cyclic Acetal Motifs for the Production of Antibody-Drug Conjugates with High Potency and Selectivity. Bioconjug Chem. 2022 Oct 19;33(10):1860-1866. doi: 10.1021/acs.bioconjchem.2c00314. Epub 2022 Sep 15.
Ref 264 One-Pot Conversion of Free Sialoglycans to Functionalized Glycan Oxazolines and Efficient Synthesis of Homogeneous Antibody-Drug Conjugates through Site-Specific Chemoenzymatic Glycan Remodeling. Bioconjug Chem. 2021 Aug 18;32(8):1888-1897. doi: 10.1021/acs.bioconjchem.1c00314. Epub 2021 Aug 5.
Ref 265 Unbiased cell surface proteomics identifies SEMA4A as an effective immunotherapy target for myeloma. Blood. 2022 Apr 21;139(16):2471-2482. doi: 10.1182/blood.2021015161.
Ref 266 Development of applicable thiol-linked antibody-drug conjugates with improved stability and therapeutic index. Drug Deliv. 2022 Dec;29(1):754-766. doi: 10.1080/10717544.2022.2039807.
Ref 267 Photoconjugation of an Fc-Specific Peptide Enables Efficient DAR 2 Antibody-Drug Conjugate Formation. Org Lett. 2020 Nov 6;22(21):8419-8423. doi: 10.1021/acs.orglett.0c03049. Epub 2020 Oct 19.
Ref 268 Design and Validation of Linkers for Site-Specific Preparation of Antibody-Drug Conjugates Carrying Multiple Drug Copies Per Cysteine Conjugation Site. Int J Mol Sci. 2020 Sep 19;21(18):6882. doi: 10.3390/ijms21186882.
Ref 269 Two engineered site-specific antibody-drug conjugates, HLmD4 and HLvM4, have potent therapeutic activity in two DLL4-positive tumour xenograft models. Am J Cancer Res. 2020 Aug 1;10(8):2387-2408. eCollection 2020.
Ref 270 Controlled coupling of an ultrapotent auristatin warhead to cetuximab yields a next-generation antibody-drug conjugate for EGFR-targeted therapy of KRAS mutant pancreatic cancer. Br J Cancer. 2020 Nov;123(10):1502-1512. doi: 10.1038/s41416-020-01046-6. Epub 2020 Sep 11.
Ref 271 Preparation and characterization of antibody-drug conjugates acting on HER2-positive cancer cells. PLoS One. 2020 Sep 28;15(9):e0239813. doi: 10.1371/journal.pone.0239813. eCollection 2020.
Ref 272 Divinylsulfonamides enable the construction of homogeneous antibody-drug conjugates. Bioorg Med Chem. 2020 Dec 1;28(23):115793. doi: 10.1016/j.bmc.2020.115793. Epub 2020 Oct 6.
Ref 273 Near-infrared-induced drug release from antibody-drug double conjugates exerts a cytotoxic photo-bystander effect. Bioeng Transl Med. 2022 Aug 21;7(3):e10388. doi: 10.1002/btm2.10388. eCollection 2022 Sep.
Ref 274 Tag-free, specific conjugation of glycosylated IgG1 antibodies using microbial transglutaminase. RSC Adv. 2022 Nov 22;12(52):33510-33515. doi: 10.1039/d2ra05630e. eCollection 2022 Nov 22.
Ref 275 Hiding Payload Inside the IgG Fc Cavity Significantly Enhances the Therapeutic Index of Antibody-Drug Conjugates. J Med Chem. 2023 Jan 12;66(1):1011-1026. doi: 10.1021/acs.jmedchem.2c01812. Epub 2022 Dec 30.
Ref 276 AXL antibody and AXL-ADC mediate antitumor efficacy via targeting AXL in tumor-intrinsic epithelial-mesenchymal transition and tumor-associated M2-like macrophage. Acta Pharmacol Sin. 2023 Jun;44(6):1290-1303. doi: 10.1038/s41401-022-01047-6. Epub 2023 Jan 17.
Ref 277 Anti-cdh6 antibody and anti-cdh6 antibody-drug conjugate.
Ref 278 Cysteine engineered antibodies and conjugates.
Ref 279 Conjugates comprising self-immolative groups and methods related thereto.
Ref 280 Bcma monoclonal antibody-drug conjugate.
Ref 281 Site-specific antibody-drug conjugation through glycoengineering.
Ref 282 An overview of huPr1-vcMMAE.
Ref 283 Site-specific conjugation of linker drugs to antibodies and resulting adcs.
Ref 284 Anti-cxcr4 antibodies and antibody-drug conjugates.
Ref 285 Covalent linkers in antibody-drug conjugates and methods of making and using the same.
Ref 286 Tridentate connexon and use thereof.
Ref 287 Antibody drug conjugates.
Ref 288 Antibody drug conjugates.
Ref 289 Anti-egfr antibodies and antibody drug conjugates.
Ref 290 Introduction to basic information on ADC drug Alpha-CD70-Mc-MMAF
Ref 291 Site-Specific Conjugation of Monomethyl Auristatin E to Anti-CD30 Antibodies Improves Their Pharmacokinetics and Therapeutic Index in Rodent Models. Mol Pharm. 2015 Jun 1;12(6):1863-71. doi: 10.1021/mp500666j. Epub 2015 Feb 9.
Ref 292 Biodistribution and efficacy of an anti-TENB2 antibody-drug conjugate in a patient-derived model of prostate cancer. Oncotarget. 2019 Oct 22;10(58):6234-6244. doi: 10.18632/oncotarget.27263. eCollection 2019 Oct 22.
Ref 293 Recombinant anti-cd30 antibodies and uses thereof; 2006-02-02
Ref 294 Tasly pharma announcement; 2020
Ref 295 Introduction to basic information on EGFRvIII/MMAE antibody drug conjugate(Abgenix, Inc.).
Ref 296 Introduction to basic information on ADC drug C-met monoclonal antibody-drug conjugate
Ref 297 Introduction to basic information on ADC drug ADC-W-2589.
Ref 298 In vitro and in vivo activity of a highly potent and novel FGFR2/FGFR4 dual targeting antibody-drug conjugate. Cancer Res (2015) 75 (15_Supplement): 1680.
Ref 299 Antibody-drug conjugates and related compounds, compositions, and methods.
Ref 300 Development and Evaluation of a Fluorescent Antibody-Drug Conjugate for Molecular Imaging and Targeted Therapy of Pancreatic Cancer. PLoS One. 2016 Jun 23;11(6):e0157762. doi: 10.1371/journal.pone.0157762. eCollection 2016.
Ref 301 Anti-ROR1 antibodies and antibody conjugates, compositions comprising Anti-ROR1 antibodies or antibody conjugates, and methods of making and using Anti-ROR1 antibodies and antibody conjugates
Ref 302 A phase Ia/Ib study of CBP-1008, a bispecific ligand drug conjugate, in patients with advanced solid tumors. Journal of Clinical Oncology 2022 40:16_suppl, 3000-3000.
Ref 303 DAC biotechnology company product pipeline
Ref 304 Introduction to basic information on ADC drug ZV203; 6 Jan 2020.
Ref 305 Conjupro biotherapeutics product pipeline
Ref 306 MEN1309/OBT076, a First-In-Class Antibody-Drug Conjugate Targeting CD205 in Solid Tumors. Mol Cancer Ther. 2019 Sep;18(9):1533-1543. doi: 10.1158/1535-7163.MCT-18-0624. Epub 2019 Jun 21.
Ref 307 Phase I Study of DMOT4039A, an Antibody-Drug Conjugate Targeting Mesothelin, in Patients with Unresectable Pancreatic or Platinum-Resistant Ovarian Cancer. Mol Cancer Ther. 2016 Mar;15(3):439-47. doi: 10.1158/1535-7163.MCT-15-0693.
Ref 308 Introduction to basic information on ADC drug trastuzumab botidotin.
Ref 309 Novel development strategies and challenges for anti-Her2 antibody-drug conjugates. Antib Ther. 2022 Jan 27;5(1):18-29. doi: 10.1093/abt/tbac001.
Ref 310 Novel bispecific antibody-drug conjugate targeting PD-L1 and B7-H3 enhances antitumor efficacy and promotes immune-mediated antitumor responses
Ref 311 A bispecific antibody-drug conjugate targeting pCAD and CDH17 has antitumor activity and improved tumor-specificity
Ref 312 A Dual-Payload Antibody-Drug Conjugate Targeting CD276/B7-H3 Elicits Cytotoxicity and Immune Activation in Triple-Negative Breast Cancer
Ref 313 A novel bispecific antibody drug conjugate targeting HER2 and HER3 with potent therapeutic efficacy against breast cancer
Ref 314 A comparison of the activity, lysosomal stability, and efficacy of legumain-cleavable and cathepsin-cleavable ADC linkers
Ref 315 A CD6-targeted antibody-drug conjugate as a potential therapy for T cell-mediated disorders
Ref 316 Development of a MMAE-based antibody-drug conjugate targeting B7-H3 for glioblastoma
Ref 317 A humanized trivalent Nectin-4-targeting nanobody drug conjugate displays potent antitumor activity in gastric cancer
Ref 318 Use of Payload Binding Selectivity Enhancers to Improve Therapeutic Index of Maytansinoid-Antibody-Drug Conjugates
Ref 319 Optimization of a pendant-shaped PEGylated linker for antibody-drug conjugates
Ref 320 Generation and Characterization of SORT1-Targeted Antibody-Drug Conjugate for the Treatment of SORT1-Positive Breast Tumor
Ref 321 An Anti-CD147 Antibody-Drug Conjugate Mehozumab-DM1 is Efficacious Against Hepatocellular Carcinoma in Cynomolgus Monkey
Ref 322 Design and synthesis of novel site-specific antibody-drug conjugates that target TROP2
Ref 323 Targeting CD44 Variant 5 with an Antibody-Drug Conjugate Is an Effective Therapeutic Strategy for Intrahepatic Cholangiocarcinoma
Ref 324 A high-affinity antibody-drug conjugates Actuximab-MMAE for potent and selective targeting of CEACAM5-Positive tumors
Ref 325 A rationally designed ICAM1 antibody drug conjugate eradicates late-stage and refractory triple-negative breast tumors in vivo
Ref 326 Anti-tissue factor antibody conjugated with monomethyl auristatin E or deruxtecan in pancreatic cancer models
Ref 327 Trastuzumab-MMAU Antibody-Auristatin Conjugates: Valine-Glucoserine Linker with Stabilized Maleimide Conjugation Improves In Vivo Efficacy and Tolerability
Ref 328 AGCM-22, a novel cetuximab-based EGFR-targeting antibody-drug-conjugate with highly selective anti-glioblastoma efficacy
Ref 329 Synthesis and evaluation of antibody-drug conjugates with high drug-to-antibody ratio using dimaleimide-DM1 as a linker- payload
Ref 330 PEGylation of Dipeptide Linker Improves Therapeutic Index and Pharmacokinetics of Antibody-Drug Conjugates
Ref 331 A CD276-Targeted Antibody-Drug Conjugate to Treat Non-Small Lung Cancer (NSCLC)
Ref 332 Exo-Cleavable Linkers: Enhanced Stability and Therapeutic Efficacy in Antibody-Drug Conjugates
Ref 333 Development of a Cytotoxic Antibody-Drug Conjugate Targeting Membrane Immunoglobulin E-Positive Cells
Ref 334 Disulfide re-bridging reagents for single-payload antibody-drug conjugates
Ref 335 Antibody-drug conjugates targeting DDR1 as a novel strategy for treatment of breast cancer
Ref 336 An auristatin-based antibody-drug conjugate targeting EphA2 in pancreatic cancer treatment
Ref 337 Use of a Cyclic α-Alkylidene-β-Diketone as a Cleavable Linker Strategy for Antibody-Drug Conjugates
Ref 338 Production of site-specific antibody conjugates using metabolic glycoengineering and novel Fc glycovariants
Ref 339 Discovery of a novel highly specific, fully human PSCA antibody and its application as an antibody-drug conjugate in prostate cancer
Ref 340 CD6-targeted antibody-drug conjugate as a new therapeutic agent for T cell lymphoma
Ref 341 Conditional activation of an anti-IgM antibody-drug conjugate for precise B cell lymphoma targeting
Ref 342 A novel and promising therapeutic approach for treating pancreatic cancer: Nectin-4-targeted antibody-drug conjugates alone or combined with autophagy inhibitors
Ref 343 Phenyldivinylsulfonamides for the construction of antibody-drug conjugates with controlled four payloads
Ref 344 A novel anti-HER2/EGFR bispecific antibody-drug conjugate demonstrates promising antitumor efficacy and overcomes resistance to HER2- or EGFR-targeted ADCs
Ref 345 Biological Evaluation of Antibody-Drug Conjugates Produced by Tag-Free Lipoate Ligase A Modification
Ref 346 A novel human single-domain antibody-drug conjugate targeting CEACAM5 exhibits potent in vitro and in vivo antitumor activity
Ref 347 Discovery of novel cMET-targeting antibody Fab drug conjugates as potential treatment for solid tumors with highly expressed cMET
Ref 348 hIMB1636-MMAE, a Novel TROP2-Targeting Antibody-Drug Conjugate Exerting Potent Antitumor Efficacy in Pancreatic Cancer
Ref 349 A simple and highly sensitive LC-MS workflow for characterization and quantification of ADC cleavable payloads
Ref 350 Broadening the Therapeutic Window of ADCs Using Site-Specific Bioconjugation Showcased by an MMAE-Containing Peptide Linker in a CD79b-Targeting ADC
Ref 351 Development of an anti-LAIR1 antibody-drug conjugate for acute myeloid leukemia therapy
Ref 352 Evaluating the Potential of Cyclodextrins in Reducing Aggregation of Antibody-Drug Conjugates with Different Payloads
Ref 353 Affinity-Directed Site-Specific Protein Labeling and Its Application to Antibody-Drug Conjugates
Ref 354 Reducing target binding affinity improves the therapeutic index of anti-MET antibody-drug conjugate in tumor bearing animals
Ref 355 Evaluation of Potency and Specificity of Cryptophycin-Loaded Antibody-Drug Conjugates
Ref 356 CSPG4 as a target for the specific killing of triple-negative breast cancer cells by a recombinant SNAP-tag-based antibody-auristatin F drug conjugate
Ref 357 AJICAP-M: Traceless Affinity Peptide Mediated Conjugation Technology for Site-Selective Antibody-Drug Conjugate Synthesis
Ref 358 Design, Synthesis, and In Vitro and In Vivo Evaluation of Cereblon Binding Bruton's Tyrosine Kinase (BTK) Degrader CD79b Targeted Antibody-Drug Conjugates
Ref 359 Humanized dual-targeting antibody-drug conjugates specific to MET and RON receptors as a pharmaceutical strategy for the treatment of cancers exhibiting phenotypic heterogeneity
Ref 360 Production and characterization of a camelid single domain anti-CD22 antibody conjugated to DM1
Ref 361 Tuneable thiol exchange linkers for traceless drug release applications in prodrugs and ADCs
Ref 362 NIR-II aza-BODIPY Platform for the Development of a Fluorescent Antibody Drug Conjugate
Ref 363 Direct Preparation of Site-Specific Antibody-Drug Conjugates with Unpurified Antibodies in Culture Medium
Ref 364 A Recognition Tag of Human Origin for Bioorthogonal Generation of Antibody-Drug Conjugates using Microbial Biotin Ligase
Ref 365 Generation and characterization of 7DC-DM1: a non-cleavable CD47-targeting antibody-drug conjugates with antitumor effects
Ref 366 Fine-tuning phenoxy silyl scaffolds for the development of glutathione-responsive prodrugs and antibody-drug conjugates
Ref 367 Harnessing acylhydrazone-oxime exchange reaction to achieve diverse synthesis of glycosite-specific antibody-drug conjugates
Ref 368 Computational-aided rational mutation design of pertuzumab to overcome active HER2 mutation S310F through antibody-drug conjugates
Ref 369 An antibody-drug conjugate targeting soluble and membrane-bound TGFα is effective against pancreatic tumors
Ref 370 Anti-CD64(scFv)-SNAP-Auristatin F: An in vitro proof of concept study for a recombinant antibody conjugate targeting CD64(+) acute monocytic leukemia
Ref 371 Modulating autophagy to boost the antitumor efficacy of TROP2-directed antibody-drug conjugate in pancreatic cancer
Ref 372 Site-Specific Antibody Conjugation Using Modified Bisected N-Glycans: Method Development and Potential toward Tunable Effector Function
Ref 373 CTLA-4 antibody-drug conjugate reveals autologous destruction of B-lymphocytes associated with regulatory T cell impairment
Ref 374 Broad-Spectrum Efficacy of CEACAM6-Targeted Antibody-Drug Conjugate with BET Protein Degrader in Colorectal, Lung, and Breast Cancer Mouse Models
Ref 375 Fertility-preserving myeloablative conditioning using single-dose CD117 antibody-drug conjugate in a rhesus gene therapy model
Ref 376 In vivo activation of FAP-cleavable small molecule-drug conjugates for the targeted delivery of camptothecins and tubulin poisons to the tumor microenvironment
Ref 377 TROP2-directed nanobody-drug conjugate elicited potent antitumor effect in pancreatic cancer
Ref 378 Effective eradication of acute myeloid leukemia stem cells with FLT3-directed antibody-drug conjugates
Ref 379 A HER2 Specific Nanobody-Drug Conjugate: Site-Selective Bioconjugation and In Vitro Evaluation in Breast Cancer Models
Ref 380 Site-Selective Tyrosine Reaction for Antibody-Cell Conjugation and Targeted Immunotherapy
Ref 381 TRBC1-targeting antibody-drug conjugates for the treatment of T cell cancers
Ref 382 Copper assisted sequence-specific chemical protein conjugation at a single backbone amide
Ref 383 AXL antibody and AXL-ADC mediate antitumor efficacy via targeting AXL in tumor-intrinsic epithelial-mesenchymal transition and tumor-associated M2-like macrophage
Ref 384 Mechanistic Characterization of Cancer-associated Fibroblast Depletion via an Antibody-Drug Conjugate Targeting Fibroblast Activation Protein
Ref 385 Efficient intracellular drug delivery by co-administration of two antibodies against cell adhesion molecule 1
Ref 386 Targeting CD33+ Acute Myeloid Leukemia with GLK-33, a Lintuzumab-Auristatin Conjugate with a Wide Therapeutic Window
Ref 387 Probing the Internalization and Efficacy of Antibody-Drug Conjugate via Site-Specific Fc-Glycan Labelling of a Homogeneous Antibody Targeting SSEA-4 Bearing Tumors
Ref 388 Linker and Conjugation Site Synergy in Antibody-Drug Conjugates: Impacts on Biological Activity
Ref 389 Synthesis of site-specific Fab-drug conjugates using ADP-ribosyl cyclases
Ref 390 PK/PD of Positively Charged ADC in Mice
Ref 391 An amino acid transporter subunit as an antibody-drug conjugate target in colorectal cancer
Ref 392 A novel SLC3A2-targeting antibody-drug conjugate exerts potent antitumor efficacy in head and neck squamous cell cancer
Ref 393 T cell receptor-directed antibody-drug conjugates for the treatment of T cell-derived cancers
Ref 394 NECTIN4-targeted antibody-drug conjugate is a potential therapeutic option for extramammary Paget disease
Ref 395 ICAM1 antibody drug conjugates exert potent antitumor activity in papillary and anaplastic thyroid carcinoma
Ref 396 Half-life extension of single-domain antibody-drug conjugates by albumin binding moiety enhances antitumor efficacy
Ref 397 Ortho-functionalized pyridinyl-tetrazines break the inverse correlation between click reactivity and cleavage yields in click-to-release chemistry
Ref 398 Antibody and antibody fragments site-specific conjugation using new Q-tag substrate of bacterial transglutaminase
Ref 399 CTLA-4 antibody-drug conjugate reveals autologous destruction of B-lymphocytes associated with regulatory T cell impairment
Ref 400 Targeting GD2-Positive Tumor Cells by Pegylated scFv Fragment-Drug Conjugates Carrying Maytansinoids DM1 and DM4
Ref 401 An antibody-drug conjugate for endometrioid carcinoma based on the expression of cell adhesion molecule 1
Ref 402 Enhancing antitumor efficacy of CLDN18.2-directed antibody-drug conjugates through autophagy inhibition in gastric cancer
Ref 403 Targeting the activated allosteric conformation of the endothelin receptor B in melanoma with an antibody-drug conjugate: mechanisms and therapeutic efficacy
Ref 404 MUC1-C dependency in drug resistant HR+/HER2- breast cancer identifies a new target for antibody-drug conjugate treatment
Ref 405 PF-08046032: A Novel, Investigational CD25-Directed Antibody-Drug Conjugate Optimized for Selective Depletion of Regulatory T Cells in Advanced Malignant Tumors
Ref 406 PCO25-210: Design of Novel Antibody Drug Conjugates Using a Fully Humanized Monoclonal Antibody Targeting the Human Neuronal Pentraxin Receptor (YB800-ADCs) for Therapeutic Intervention in Oncology
Ref 407 Correction to: Method development of a novel PK assay for antibody-conjugated drug measurement of ADCs using peptide-linker drug analyte
Ref 408 TAVO605, a novel CD318 (CDCP1) ADC, for the treatment of solid cancers that are non-responding or resistant to Enhertu treatment
Ref 409 Preclinical development of TGW101, a first in class click-cleavable ADC with MMAE against non-internalizing pan-carcinoma marker TAG72
Ref 410 A next generation ADC: AR153, pH-dependent anti-B7H3 MMAE
Ref 411 IDP-001 is a potent bispecific ADC with in vivo activity against mouse xenograft tumor models expressing EGFR and CDCP1
Ref 412 Preclinical evaluation of SDV2102, a novel PSMA-targeting DAR1 ADC for mCRPC treatment
Ref 413 AT2604 is a highly efficacious ADC targeting alkaline phosphatases ALPP and ALPPL2
Ref 414 Development and preclinical activity of BSI-721, a novel antibody-drug conjugate (ADC) targeting cadherin 17 (CDH17) in gastrointestinal cancers
Ref 415 Development and characterization of an antibody-drug conjugate (ADC) utilizing PB-223, a novel monoclonal antibody (mAb) specifically targeting core 2 O-glycans on human carcinomas
Ref 416 The anti-tumor activity of a novel anti-Her2 and anti-c-Met bispecific antibody-drug conjugate
Ref 417 Assessing efficacy of anti-glypican-1antibody-drug conjugate as potential therapeutic approach for gastric cancer
Ref 418 PLB-002 is a novel Claudin 6 antibody-drug conjugate for ovarian cancer and testicular germ cell cancer
Ref 419 Novel tryptophan-based antibody-drug conjugate (ADC) targeting EGFR-positive lung cancer demonstrates robust antitumor efficacy by triggering immunogenic cell death
Ref 420 PF-08046031: A promising first-in-class antibody-drug conjugate for targeting novel tumor antigen in melanoma
Ref 421 Translational medicine studies of BR111, a biparatopic anti-ROR1 antibody drug conjugate for hematological and solid tumor treatment
Ref 422 Development of potent FGFR4-targeted antibody-drug conjugate therapies for rhabdomyosarcoma and other cancers expressing FGFR4
Ref 423 ADRX-0134 as a novel auristatin-based NaPi2b antibody-drug conjugate with widened therapeutic window
Ref 424 Antibody-drug conjugates
Ref 425 Conjugate antibody-drug comprising human trop2 antibody and use of the same
Ref 426 Antibodies targeting ITGA2 and antibody-drug conjugates comprising the antibodies
Ref 427 CD38 antibody-drug conjugates
Ref 428 CD44-specific antibodies
Ref 429 Antibody-drug conjugates based on eribulin and methods of use
Ref 430 Fan bracket
Ref 431 Anti-cd48 antibody, antibody drug conjugate and its use
Ref 432 Antibodies against monomethyl auristatin E and uses thereof
Ref 433 Novel anti-prostate-specific membrane antigen (PSMA) antibody drug conjugates
Ref 434 Allenamide linkers for antibody-drug conjugates
Ref 435 Methods of using antibody-drug conjugates
Ref 436 Methods for treating AXL-expressing cancer with anti-AXL antibodies, antibody fragments and their immune conjugates
Ref 437 Screening of site-specific conjugation sites of cysteine-engineered antibody-toxin complexes (TDCs)
Ref 438 Intercellular adhesion molecule 1 (ICAM1) antibody drug conjugate and uses thereof
Ref 439 Antibody binding specifically to GRP94 or antibody drug conjugate containing his antigen binding fragment and drug
Ref 440 Novel linkers for antibody-drug conjugates and related compounds, compositions, and methods of use
Ref 441 Methods and compositions for determining the biodistribution of activatable anti-CD166 antibody conjugates
Ref 442 Antibodies, expression vectors, recombinant prokaryotic host cells, pharmaceutical compositions, and uses of the antibody
Ref 443 Novel maytansinoids as ADC payloads and their use for the treatment of cancer
Ref 444 Antibody-drug conjugate and application thereof
Ref 445 Binding molecules targeting ROR1 and uses thereof
Ref 446 Antibody-drug conjugate
Ref 447 Oligosaccharide linker, linker-payload comprising the same and glycan chain-remodeled antibody-drug conjugate, preparation methods and uses thereof
Ref 448 Anti-CD228 antibodies and antibody-drug conjugates
Ref 449 Glyco-engineered antibody-drug conjugates comprising an oxime linker
Ref 450 Anti-MERTK agonistic antibodies and uses thereof
Ref 451 Anti-EGFR antibodies, antibody-drug conjugates, pharmaceutical compositions and uses for treating cancer and inhibiting or reducing solid tumor growth
Ref 452 Anti-mesothelin antibodies and uses thereof
Ref 453 Monoclonal antibodies targeting GPC3 and antibody-drug conjugates comprising the antibodies
Ref 454 Targeted delivery of dual payloads of MMAF or MMAE and TLR7 agonists for the treatment of cancer
Ref 455 Anti-sez6l2 antibodies and antibody-drug conjugates
Ref 456 Anti-TPBG/MET antibodies and uses thereof
Ref 457 Antibody-drug conjugate comprising modified antibody
Ref 458 Tetravalent antibody-drug conjugates and uses thereof
Ref 459 Selenium antibody conjugates
Ref 460 Anti-CD6 antibody conjugates for treating t-cell and b-cell mediated disorders, and t-cell and b-cell cancers
Ref 461 Antibody conjugate comprising anti-P-cadherin antibody and uses thereof
Ref 462 Antibody-drug conjugates for removing hematopoietic stem cells
Ref 463 Anti-ror1 antibodies and their uses
Ref 464 Antibody-drug conjugates targeting uPARAP comprising irinotecan derivatives
Ref 465 Methods for producing antibody-linker conjugates
Ref 466 Linker, antibody-drug conjugate including same, and uses thereof
Ref 467 Use of hydroxypropyl-β-cyclodextrin in stabilizing antibody-drug conjugate formulations
Ref 468 Antibody-drug conjugates
Ref 469 Improved antibody-payload conjugates (APCs) prepared by site-specific conjugation utilizing genetic code expansion
Ref 470 Antibody-drug conjugate intermediate SET0562, and its preparation and uses
Ref 471 Antibodies specifically binding ROR1, their drug conjugates, preparation methods and uses
Ref 472 CD70 antibody drug conjugates and methods of using the same
Ref 473 Humanized L1CAM antibody-drug conjugate
Ref 474 Anti-EDB antibodies and antibody-drug conjugates
Ref 475 Anti-ROR1 antibodies and antibody conjugates, compositions comprising Anti-ROR1 antibodies or antibody conjugates, and methods of making and using Anti-ROR1 antibodies and antibody conjugates
Ref 476 Anti-mesothelin antibody and antibody drug conjugate thereof
Ref 477 Ph-dependent Anti-sulfated glycosaminoglycan antibody and antibody-drug conjugate
Ref 478 Anti-basal cell adhesion molecule antibody-drug conjugate
Ref 479 Binding molecule directed to ror1 and its use
Ref 480 Anti-tissue factor antibodies, antibody-drug conjugates, and related methods
Ref 481 Antibody compositions comprising Fc mutations and site-specific conjugation properties for use in treating cancer, immunological disorders, and methods thereof
Ref 482 Pharmaceutical composition comprising anti-CD79b antibody-drug conjugate and use thereof
Ref 483 Anti-CEA antibody drug conjugates and methods of use
Ref 484 Anti-PSMA antibody-drug conjugates and their preparation methods and applications
Ref 485 Antibody-drug conjugates cleavable in a tumor microenvironment
Ref 486 TRBC targeting antibody-drug conjugates
Ref 487 Oligosaccharide linker, linker-payload comprising the same and glycan chain-remodeled antibody-drug conjugate, preparation methods and uses thereof
Ref 488 Anti-C10orf54 antibodies and uses thereof
Ref 489 Antibody-drug conjugates and production thereof
Ref 490 Anti-ErbB2 antibody-drug conjugate and composition thereof, preparation method therefor, and use thereof
Ref 491 CD44-specific antibodies and their antibody-drug conjugates
Ref 492 Preparation and use of anti-FSHR antibody and antibody-drug conjugate thereof
Ref 493 Application of ALK inhibitors together with EGFR-targeted antibody-drug conjugates in the preparation of medicines for treating lung cancer
Ref 494 Nitroaryl-based linkers, antibody-drug conjugates comprising the linkers and uses thereof
Ref 495 IGF-1R antibody-drug conjugate and its use for the treatment of cancer
Ref 496 Peptide tags, compositions and methods for site-specific protein conjugation
Ref 497 Antibody-drug conjugates containing an anti-mesothelin antibody and uses thereof
Ref 498 Bisecting-glycan bridged conjugation for producing glycoprotein conjugates
Ref 499 Bromomethylpyrazine-based drug conjugates and ADCs
Ref 500 Ror1-targeted binding molecules and their Applications
Ref 501 Anti-doppel antibody drug conjugates
Ref 502 Anti-CD39 antibody-drug conjugate and use thereof
Ref 503 Oligosaccharide linkers, linker-payloads comprising the linkers, and glycan chain-remodeled antibody-drug conjugates, preparation methods and uses thereof
Ref 504 Interleukin-13 receptor subunit alpha-2 antibody-drug conjugates and uses thereof
Ref 505 Anti-CD37 antibody-drug conjugate
Ref 506 Antibody-multidrug conjugate
Ref 507 Antibody-drug complexes containing anti-CD138 antibodies
Ref 508 Immunomodulator antibody drug conjugates and uses thereof
Ref 509 Site-specific antibody-drug conjugation through glycoengineering
Ref 510 Uses of an antibody-drug conjugate
Ref 511 Antibody-drug conjugates targeting receptor tyrosine kinase EphA5
Ref 512 p-Aminobenzyl linkers, preparation methods and uses in conjugates
Ref 513 Novel antibody drug conjugates with novel NaPi2b antibodies, therapeutic methods and uses thereof
Ref 514 Intercellular adhesion molecule 1 (ICAM1) antibody-drug conjugates and uses thereof
Ref 515 Anthracycline disulfide intermediates, antibody-drug conjugates and methods
Ref 516 Methods for preparing protein-small-molecule drug conjugates and applications thereof
Ref 517 Antibody-drug conjugates and applications in antibody-mediated drug delivery
Ref 518 Anti-huLRRC15 antibody drug conjugates and methods for their use
Ref 519 Preparation method for doubly substituted bridge-linked antibody-drug conjugates
Ref 520 Rapid-release antibody-drug conjugates
Ref 521 Anti-human EGFR antibody-drug conjugates and their preparation methods and applications
Ref 522 Pharmaceutical compositions of anti-HER2 antibody-drug conjugate
Ref 523 Antibody drug conjugates having linkers comprising hydrophilic groups
Ref 524 Site-specific conjugation of antibodies
Ref 525 Peptide linkers containing glycosides for antibody-drug conjugates
Ref 526 Azobenzene-Based Linker Strategy for Selective Activation of Antibody-Drug Conjugates
Ref 527 Site-Selective Antibody Conjugation with Dibromopyrazines
Ref 528 Branched pegylated linker-auristatin to control hydrophobicity for the production of homogeneous minibody-drug conjugate against HER2-positive breast cancer
Ref 529 Radiotherapy activates picolinium prodrugs in tumours