General Information of This Target
Target ID
PATR0CXRBX
Target Name
Microtubule (MT)
Function
Microtubules are polymers of tubulin that form part of the cytoskeleton and provide structure and shape to eukaryotic cells. Microtubules play an important role in a number of cellular processes. They are involved in maintaining the structure of the cell and, together with microfilaments and intermediate filaments, they form the cytoskeleton. They also make up the internal structure of cilia and flagella. They provide platforms for intracellular transport and are involved in a variety of cellular processes, including the movement of secretory vesicles, organelles, and intracellular macromolecular assemblies.

    Click to Show/Hide
Full List of The ADC Related to This Target
Approved
Click To Hide/Show 11 ADC Related to This Stage
ADC Info ADC Name Antibody Antigen Payload Linker Ref
Trastuzumab botidotin
Trastuzumab
ERBB2
Duostatin 5
K-lock-Val-Cit-PABC
[1]
Becotatug vedotin
JMT101
EGFR
Monomethyl auristatin E
Mc-Val-Cit-PABC
[2]
Belantamab mafodotin
Belantamab
TNFRSF17
Monomethyl auristatin F
Maleimido-caproyl
[3]
Brentuximab vedotin
Brentuximab
TNFRSF8
Monomethyl auristatin E
Mc-Val-Cit-PABC
[4]
Disitamab vedotin
Hertuzumab
ERBB2
Monomethyl auristatin E
Mc-Val-Cit-PABC
[5]
Enfortumab vedotin
Enfortumab
NECTIN4
Monomethyl auristatin E
Mc-Val-Cit-PABC
[6]
Mirvetuximab soravtansine
Mirvetuximab
FOLR1
Mertansine DM4
Sulfo-SPDB
[7]
Polatuzumab vedotin
Polatuzumab
CD79B
Monomethyl auristatin E
Mc-Val-Cit-PABC
[8]
Telisotuzumab vedotin
Telisotuzumab
MET
Monomethyl auristatin E
Mc-Val-Cit-PABC
[9]
Tisotumab vedotin
Tisotumab
F3
Monomethyl auristatin E
Mc-Val-Cit-PABC
[10]
Trastuzumab emtansine
Trastuzumab
ERBB2
Mertansine DM1
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
[11]
Phase 3
Click To Hide/Show 8 ADC Related to This Stage
ADC Info ADC Name Antibody Antigen Payload Linker Ref
CMG-901
Sonesitatug
CLDN18.2
Monomethyl auristatin E
Mc-Val-Cit-PABC
[12]
DP-303c
Trastuzumab
ERBB2
Monomethyl auristatin E
NH2-PEG3-Val-Cit-PABC
[13]
FS-1502
Trastuzumab
ERBB2
Monomethyl auristatin F
A cancer-selective cleavable -glucuronide linker
[14]
LM-302
Anti-CLDN18.2 mAb
CLDN18.2
Monomethyl auristatin E
Mc-Val-Cit-PABC
[15]
SGN-B6A
Sigvotatug
ITGB6
Monomethyl auristatin E
Mc-Val-Cit-PABC
[16]
SGN-PDL1V
Humanized Anti-PD-L1 SGN-PDL1V mAb
CD274
Monomethyl auristatin E
Mc-Val-Cit-PABC
[17]
Tusamitamab ravtansine
Tusamitamab
CEACAM5
Mertansine DM4
N-succinimidyl 4-(2-pyridyldithio) butanoate (SPDB)
[18]
Upifitamab rilsodotin
XMT-1535
SLC34A2
Auristatin F hydroxypropylamide (AF-HPA)
Dolaflexin polymer
[19]
Phase 3 (Terminated)
Click To Hide/Show 2 ADC Related to This Stage
ADC Info ADC Name Antibody Antigen Payload Linker Ref
BAT8001
BAT0606
ERBB2
Maytansinoid derivative of batansine
6-Maleimidocaproic acid
[20]
TAA-013
Trastuzumab
ERBB2
Mertansine DM1
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
[21]
Phase 2/3
Click To Hide/Show 1 ADC Related to This Stage
ADC Info ADC Name Antibody Antigen Payload Linker Ref
Luveltamab tazevibulin
Luveltamab
FOLR1
SC209
Val-Cit-PABA
[22]
Phase 2
Click To Hide/Show 12 ADC Related to This Stage
ADC Info ADC Name Antibody Antigen Payload Linker Ref
ARX-788
Modified pAcPhe trastuzumab
ERBB2
Monomethyl auristatin F
Hydroxylamine-PEG4
[23]
BB-1701
Undisclosed
ERBB2 exon 20
Eribulin
Mc-PEG2-Val-Cit-PABC
[24]
DX126-262
DX-CHO9
ERBB2
Tubulysin B analog Tub114
Mal-PEG10-Ala-Ala-linker
[25]
FOR-46
Anti-CD46 fully human Anti-ody
CD46
Monomethyl auristatin E
Mc-Val-Cit-PABC
[26]
Ladiratuzumab vedotin
Ladiratuzumab
SLC39A6
Monomethyl auristatin E
Mc-Val-Cit-PABC
[27]
MRG-001
Chimeric Anti-CD20 mAb
MS4A1
Monomethyl auristatin E
Mc-Val-Cit-PABC
[28]
MRG-002
MAB802
ERBB2
Monomethyl auristatin E
Mc-Val-Cit-PABC
[29]
Ozuriftamab vedotin
Ozuriftamab
ROR2
Monomethyl auristatin E
Mc-Val-Cit-PABC
[30]
Praluzatamab ravtansine
Praluzatamab
ALCAM
Mertansine DM4
N-succinimidyl 4-(2-pyridyldithio) butanoate (SPDB)
[31]
RC-108
Undisclosed
MET
Monomethyl auristatin E
Mc-Val-Cit-PABC
[32]
SHR-4602
Pertuzumab
ERBB2
Eribulin derivatives ER300
Stable enzyme-cleavable linker
[33]
Zilovertamab vedotin
Cirmtuzumab
ROR1
Monomethyl auristatin E
Mc-Val-Cit-PABC
[34]
Phase 2 (Terminated)
Click To Hide/Show 11 ADC Related to This Stage
ADC Info ADC Name Antibody Antigen Payload Linker Ref
AGS-16C3F
Anti-ENPP3 AGS-16C3F mAb
ENPP3
Monomethyl auristatin F
Maleimido-caproyl
[35]
Anetumab ravtansine
Anetumab
MSLN
Mertansine DM4
N-succinimidyl 4-(2-pyridyldithio) butanoate (SPDB)
[36]
Cantuzumab ravtansine
Cantuzumab
MUC1
Mertansine DM4
N-succinimidyl 4-(2-pyridyldithio) butanoate (SPDB)
[37]
CDX-011
CR-011
GPNMB
Monomethyl auristatin E
Mc-Val-Cit-PABC
[38]
Coltuximab ravtansine
Coltuximab
CD19
Mertansine DM4
N-succinimidyl 4-(2-pyridyldithio) butanoate (SPDB)
[39]
Indusatumab vedotin
Indusatumab
GUCY2C
Monomethyl auristatin E
Mc-Val-Cit-PABC
[40]
Lifastuzumab vedotin
Lifastuzumab
SLC34A2
Monomethyl auristatin E
Mc-Val-Cit-PABC
[41]
Lorvotuzumab mertansine
Lorvotuzumab
NCAM1
Mertansine DM1
N-succinimidyl 4-(2-pyridyldithio) pentanoate (SPP)
[42]
Naratuximab emtansine
Naratuximab
CD37
Mertansine DM1
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
[43]
PSMA-ADC
Fully human IgG1 Anti-PSMA mAb
FOLH1
Monomethyl auristatin E
Mc-Val-Cit-PABC
[44]
SAR-566658
Anti-CA6 mAb huDS6
CA6
Mertansine DM4
N-succinimidyl 4-(2-pyridyldithio) butanoate (SPDB)
[45]
Phase 1/2
Click To Hide/Show 18 ADC Related to This Stage
ADC Info ADC Name Antibody Antigen Payload Linker Ref
9MW-2821
Bulumtatug
NECTIN4
Monomethyl auristatin E
IDM-Val-Cit-PBCA
[46]
BB-1705
Undisclosed
EGFR
Eribulin
Mc-PEG2-Val-Cit-PABC
[47]
BIO-106
Undisclosed
TACSTD2
TAMTM
Undisclosed
[48]
CRB-701
Undisclosed
NECTIN4
Monomethyl auristatin E
NH2-PEG3-Val-Cit-PABC
[49]
CX-2029
Anti-CD71 CX-151 probody
TFRC
Monomethyl auristatin E
Mc-Val-Cit-PABC
[50]
Farletuzumab ecteribulin
Farletuzumab
FOLR1
Eribulin
Mal-PEG2Val-Cit-PAB-OH
[51]
ILB-3101
Undisclosed
CD276
Eribulin
Undisclosed
[52]
IMGC-936
MGA021
ADAM9
DM21-C
Mc-Ala-Ala-Ala
[53]
JK-06
Undisclosed
TPBG
Monomethyl auristatin E
Undisclosed
[54]
LCB-84
Hu2G10
TACSTD2
Monomethyl auristatin E
b-glucuronidase cleavable linker
[55]
LM-305
Undisclosed
GPRC5D
Monomethyl auristatin E
Mc-Val-Cit-PABC
[56]
Mecbotamab vedotin
Mecbotamab
AXL
Monomethyl auristatin E
Mc-Val-Cit-PABC
[57]
MRG-004A
Undisclosed
F3
Monomethyl auristatin E
Valine-Citrulline (BCN-valyl-citrulline; Protease-cleavable linker)
[58]
PEN-221
Undisclosed
SSTR2
Mertansine DM1
Disulfide cleavable linker
PRO-1107
Undisclosed
PTK7
Monomethyl auristatin E
Undisclosed
RC-118
Ciletatug
CLDN18.2
Monomethyl auristatin E
Mc-Val-Cit-PABC
[59]
RC-88
Misitatug
MSLN
Monomethyl auristatin E
Mc-Val-Cit-PABC
[60]
REGN5093-M114
REGN5093
MET
Maytansine derivative M24
Valeramide-Val-Cit-PABC
[61]
Phase 1/2 (Terminated)
Click To Hide/Show 12 ADC Related to This Stage
ADC Info ADC Name Antibody Antigen Payload Linker Ref
AVID-100
MAB100
EGFR
Mertansine DM1
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
[62]
BMS-986148
BMS-986021
MSLN
Tubulysin
Mc-Val-Cit
[63]
BMS-986183
Undisclosed
GPC3
Tubulysin
Valine-Citrulline
Depatuxizumab mafodotin
Depatuxizumab
EGFR
Monomethyl auristatin F
Maleimido-caproyl
[64]
Enapotamab vedotin
AXL-107
AXL
Monomethyl auristatin E
Mc-Val-Cit-PABC
[65]
Indatuximab ravtansine
Indatuximab
SDC1
Mertansine DM4
N-succinimidyl 4-(2-pyridyldithio) butanoate (SPDB)
[66]
Lonigutamab ugodotin
Lonigutamab
IGF1R
F554443
Maleimido-caproyl
[67]
MEDI-4276
MEDI-4276
HER2 ECD2; HER2 ECD4
AZ13599185
Maleimido-caproyl based linker
[68]
MLN-2704
MLN591
FOLH1
Mertansine DM1
Thiopentanoate linker
[69]
OBI-999
OBI-888
Globo H (globotriaosylceramide)
Monomethyl auristatin E
ThioBridge-PEG24-Val-Cit-PABC
[70]
STI-6129
SC16.3
CD38
Duostatin 5.2
Non-polyethylene glycol linker
[71]
STRO-001
Bezetabart
CD74
Maytansinoid derivative
Cys-12 ADC linker
[72]
Phase 1
Click To Hide/Show 49 ADC Related to This Stage
ADC Info ADC Name Antibody Antigen Payload Linker Ref
AB-160
Bevacizumab
VEGFA
Paclitaxel
Undisclosed
[73]
ADRX-0706
Undisclosed
NECTIN4
AP052
Adcentrx proprietary linker
[74]
AGX101
Undisclosed
TM4SF1
Maytansine
Non-cleavable linker
[75]
AMT-151
Ab-151
FOLR1
Duostatin 5
Undisclosed
[76]
ARX-305
A proprietary, humanized, anti-CD70 antibody
CD70
Monomethyl auristatin F
Oxime-PEG3
[77]
ARX-517
Undisclosed; a humanized anti-PSMA antibody, https://aacrjournals.org/mct/article/23/12/1842/750247
FOLH1
Monomethyl auristatin F
Oxime-PEG3
[78]
ASN-004
Anti-5T4 scFv-Fc Anti-ody
TPBG
Auristatin F hydroxypropylamide (AF-HPA)
Fleximer polymer
[79]
ATG-022
Undisclosed
CLDN18.2
Monomethyl auristatin E
Mc-Val-Cit-PABC
[80]
B-003
Trastuzumab
ERBB2
Mertansine DM1
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
[81]
BA-1301
Undisclosed
CLDN18.2
Duostatin 5
Undisclosed
[82]
BA-1302
Undisclosed
MELTF
Monomethyl auristatin E
MC-Ala-(glucuronide)-PABC
[82]
BB-1709
Undisclosed
NT5E
Monomethyl auristatin E
Undisclosed
[83]
BC3195
Undisclosed
CDH3
Monomethyl auristatin E
Valine-Citrulline
[84]
BI0106
Undisclosed
TACSTD2
Undisclosed
Undisclosed
BL-B16D1
Undisclosed
EGFR; ERBB3
Undisclosed
Undisclosed
BL-M17D1
Undisclosed
ERBB2
Undisclosed
Undisclosed
BRY-812
Undisclosed
SLC39A6
Monomethyl auristatin E
Undisclosed
[85]
DXC-004A
Nimotuzumab derivative
EGFR
Tubulysin B analog
Undisclosed
[86]
DXC-005
Undisclosed
MUC1
Tubulysin B analog Tub201
Undisclosed
[86]
DXC-007
A recombinant humanized anti-CD33 monoclonal antibody
CD33
Tubulysin B analog Tub255
Undisclosed
EBC-129
Undisclosed
CEACAM5; CEACAM6
Monomethyl auristatin E
Mc-Val-Cit-PABC
[87]
F0002-ADC
Brentuximab
TNFRSF8
Mertansine DM1
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
[88]
GQ-1001
Trastuzumab
ERBB2
Mertansine DM1
MCC-Gly6-Thr-Glu3-Pro-Leu-Ala3-Leu
[89]
HDM-2005
Undisclosed
ROR1
Undisclosed
Undisclosed
IMGN151
Opugotamig
FOLR1
DM21-C
Stable cleavable peptide linker
[90]
INA03
A humanized anti-CD71 antibody
TFRC
Monomethyl auristatin E
APN-PEG5-Val-Cit-PABC
JS107
Undisclosed
CLDN18.2
Monomethyl auristatin E
Undisclosed
[91]
KM501
Undisclosed
HER2 ECD2; HER2 ECD4
Monomethyl auristatin E
Undisclosed
[92]
LNCB74
An anti-human-B7-H4 IgG1k monoclonal antibody
VTCN1
Monomethyl auristatin E
b-glucuronidase linker
LY-4101174
Undisclosed
NECTIN4
Monomethyl auristatin E
maleimide-b-glucuronide poly-sarcosine linker
M-1231
A antibody scaffold targeting tumor-associated MUC1 and EGFR
EGFR; MUC1
SC209
DBCO-Val-Cit-PABC
[93]
MEN-1309
MBH-1309
LY75
Mertansine DM4
N-succinimidyl 4-(2-pyridyldithio) butanoate (SPDB)
[94]
MYTX-011
pH-dependent antic-MET antibody
MET
Monomethyl auristatin E
Mc-Val-Cit-PABC
[95]
NBT508
Undisclosed
CD79B
Monomethyl auristatin E
Proprietary site- specific linker (TetraM; Cleavable linker)
[96]
NN-3201
NN2101
KIT
Monomethyl auristatin E
Site-specific, cleavable peptide linker
[97]
OMTX-705
OMTX005
FAP
TAM470
Mc-Val-Cit-PABC-PEG3
[98]
PYX-201
Micvotabart
FN1
Auristatin 0101
Mc-Val-Cit-PABC
[99]
Recombinant anti-HER2 humanized mAb-DM1
Undisclosed
ERBB2
Mertansine DM1
Undisclosed
[14]
SGN-35T
Brentuximab
TNFRSF8
Monomethyl auristatin E
D-leucine-alanine-glutamate tripeptide linker
SGN-B7H4V
Felmetatug
VTCN1
Monomethyl auristatin E
Mc-Val-Cit-PABC
[100]
SMP-656
Undisclosed
ERBB2
Eribulin
SuperHydraTM linker
[101]
TORL-1-23
Undisclosed
CLDN6
Monomethyl auristatin E
Valine-Citrulline (Cleavable linker)
[102]
TORL-2-307-ADC
Undisclosed
CLDN18.2
Monomethyl auristatin E
Cleavable linker
[102]
TORL-3-600
Undisclosed
CDH17
Monomethyl auristatin E
Undisclosed
[103]
TORL-4-500
a humanized monoclonal antibody
DLK1
Monomethyl auristatin E
Dipeptide valine-citrulline linker
[104]
TRS-005
Undisclosed
MS4A1
Monomethyl auristatin E
Mc-Val-Cit-PABC
[105]
XB-010
Undisclosed
TPBG
Monomethyl auristatin E
RED-601
[106]
XMT-1660
Emiltatug
VTCN1
Dolasynthen
Cleavable ester linker
[107]
ZV0203
Pertuzumab
ERBB2
Duostatin 5
Pip-Val-Cit
[108]
Phase 1 (Terminated)
Click To Hide/Show 63 ADC Related to This Stage
ADC Info ADC Name Antibody Antigen Payload Linker Ref
AbGn-107
Undisclosed
AG7
Mertansine DM4
Valine-Citrulline
[109]
AGS-62P1
A human IgG1 monoclonal antibody against FLT3
FLT3
AGD-0182
Alkoxyamine linker
[110]
AGS-67E
AGS67C
CD37
Monomethyl auristatin E
Mc-Val-Cit-PABC
[111]
AMG-172
Anti-CD70 AMG172 mAb
CD70
Mertansine DM1
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
[112]
AMG-224
Anti-human BCMA IgG1 Anti-ody
TNFRSF17
Mertansine DM1
MCC
[113]
AMG-595
a fully human, anti-EGFRvIII monoclonal antibody
EGFRvIII
Mertansine DM1
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
[114]
Aprutumab ixadotin
Aprutumab
FGFR2
Auristatin W
Caproyl acid
[115]
ASG-5ME
Human IgG2 Anti-SLC44A4 mAb
SLC44A4
Monomethyl auristatin E
Mc-Val-Cit-PABC
[116]
AVE-9633
Anti-CD33 mAb huMy9-6
CD33
Mertansine DM4
N-succinimidyl 4-(2-pyridyldithio) butanoate (SPDB)
[117]
Azintuxizumab vedotin
Azintuxizumab
SLAMF7
Monomethyl auristatin E
Mc-Val-Cit-PABC
[118]
BAT8003
Undisclosed
TACSTD2
Maytansinoid derivative of batansine
6-Maleimidocaproic acid
[119]
BAY79-4620
3ee9
CA9
Monomethyl auristatin E
Valine-Citrulline
[120]
BIIB-015
Anti-TDGF1 mAb huB3F6
TDGF1
Mertansine DM4
N-succinimidyl 4-(2-pyridyldithio) butanoate (SPDB)
[121]
Bivatuzumab mertansine
Bivatuzumab
CD44
Mertansine DM1
N-succinimidyl 4-(2-pyridyldithio) pentanoate (SPP)
[122]
Cantuzumab mertansine
Cantuzumab
MUC1
Mertansine DM1
N-succinimidyl 4-(2-pyridyldithio) pentanoate (SPP)
[123]
CDX-014
CR014
HAVCR1
Monomethyl auristatin E
Mc-Val-Cit-PABC
[124]
Cofetuzumab pelidotin
Cofetuzumab
PTK7
Auristatin 0101
Mc-Val-Cit-PABC
[125]
DEDN-6526A
MEDN6000A
EDNRB
Monomethyl auristatin E
Mc-Val-Cit-PABC
[126]
DFRF-4539A
MFRF3266A
FCRL5
Monomethyl auristatin E
Mc-Val-Cit-PABC
[127]
DLYE5953A
MLYE4489A
LY6E
Monomethyl auristatin E
Mc-Val-Cit-PABC
[128]
DMOT4039A
Humanized IgG1 Anti-MSLN mAb h7D9.v3
MSLN
Monomethyl auristatin E
Mc-Val-Cit-PABC
[129]
DMUC-4064A
MMUC3333A
MUC16
Monomethyl auristatin E
Mc-Val-Cit-PABC
[130]
GB-251
Undisclosed
ERBB2
Monomethyl auristatin E
Proprietary site- specific linker (BiM; Cleavable linker)
[25]
HKT-288
Fully human Anti-CDH6 HKT-288 mAb
CDH6
Mertansine DM4
Sulfo-SPDB
[131]
HM2- MMAE
Trastuzumab variant
ERBB2
Monomethyl auristatin E
Valine-Citrulline (Cleavable linker)
[132]
Iladatuzumab vedotin
Iladatuzumab
CD79B
Monomethyl auristatin E
Mc-Val-Cit-PABC
[133]
IMGN388
Intetumumab
ITGAV
Mertansine DM4
SPDB
[134]
Ispectamab debotansine
Ispectamab
TNFRSF17
Maytansinoid derivative
Cys-12 ADC linker
[135]
JBH-492
A humanized Fc-silenced anti-CCR7 IgG1 antibody
CCR7
Mertansine DM4
A cleavable linker
[136]
JS108
Undisclosed
TACSTD2
Tubulysin 196
2,3-disubstituted long side-chain hydrolysis-resistant linker
[86]
Laprituximab emtansine
Laprituximab
EGFR
Mertansine DM1
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
[137]
LOP-628
humanized Anti-KIT mAb LMJ729
KIT
Mertansine DM1
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
[138]
Losatuxizumab vedotin
Losatuxizumab
EGFR
Monomethyl auristatin E
Mc-Val-Cit-PABC
[139]
Lupartumab amadotin
Lupartumab
LYPD3
Auristatin W
Mc-hydrazide linker
[140]
LY-3076226
IMC-D11
FGFR3
Mertansine DM4
N-succinimidyl 4-(2-pyridyldithio) butanoate (SPDB)
[141]
MEDI-547
Anti-EPHA2 mAb 1C1
EPHA2
Monomethyl auristatin F
Maleimido-caproyl
[142]
MM-310
Undisclosed
EPHA2
Docetaxel
Undisclosed
[143]
PCA-062
CQY684
CDH3
Mertansine DM1
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
[144]
PF-06263507
PF-06281192
TPBG
Monomethyl auristatin F
Maleimido-caproyl
[145]
PF-06650808
Anti-NOTCH3 mAb hu28
NOTCH3
Auristatin 0101
Mc-Val-Cit-PABC
[146]
PF-06664178
PF-06478924
TACSTD2
Auristatin 0101
AcLys-Val-Cit-PABC
[147]
PF-06804103
T-(kK183C+K290C)
ERBB2
Auristatin 0101
Mc-Val-Cit-PABC
[148]
Pinatuzumab vedotin
Pinatuzumab
CD22
Monomethyl auristatin E
Mc-Val-Cit-PABC
[149]
Samrotamab vedotin
Samrotamab
LRRC15
Monomethyl auristatin E
Mc-Val-Cit-PABC
[150]
SAR-428926
Undisclosed
LAMP1
Mertansine DM4
N-succinimidyl 4-(2-pyridyldithio) butanoate (SPDB)
[151]
SGN CD48A
Humanized Anti-SLAMF2 SGN-CD48A mAb
CD48
Monomethyl auristatin E
#NAME?
[152]
SGN-ALPV
h12F3
ALPG; ALPP(P05187)
Monomethyl auristatin E
Mc-Val-Cit-PABC
[153]
SGN-CD19A
Denintuzumab
CD19
Monomethyl auristatin F
Maleimido-caproyl
[154]
SGN-CD228A
hL49
MELTF
Monomethyl auristatin E
b-glucuronidase cleavable linker
[155]
SGN-CD47M
A humanized antiCD47 IgG1 mAb
CD47
Monomethyl auristatin E
Metalloproteinases cleavable linker
SGN-STNV
Undisclosed
Onco-foetal sialyl-Tn
Monomethyl auristatin E
Mc-Val-Cit-PABC
[156]
SHR-A1201
Trastuzumab
ERBB2
Mertansine DM1
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
[157]
SHR-A1403
A humanised anti-c-MET IgG2 monoclonal antibody
MET
SHR152852
L2-MC
[158]
Sirtratumab vedotin
Sirtratumab
SLITRK6
Monomethyl auristatin E
Mc-Val-Cit-PABC
[159]
Sofituzumab vedotin
Anti-MUC16 Anti-ody 3A5
MUC16
Monomethyl auristatin E
Mc-Val-Cit-PABC
[160]
SYSA-1801
Anti-CLDN18.2 mAb SYSA-1801
CLDN18.2
Monomethyl auristatin E
PEG3-Val-Cit-PABC
[161]
TRPH-222
Undisclosed
CD22
Maytansinoid derivative of TRPH-222
HIPS-4AP
[162]
Vandortuzumab vedotin
Vandortuzumab
STEAP1
Monomethyl auristatin E
Mc-Val-Cit-PABC
[163]
Vorsetuzumab mafodotin
Vorsetuzumab
CD70
Monomethyl auristatin F
Maleimido-caproyl
[164]
XB-002
Samatatug
F3
ZD02044
Mc-PEG3-Val-Cit
[165]
XMT-1522
XMT-1519
ERBB2
Auristatin F hydroxypropylamide (AF-HPA)
Fleximer polymer
[166]
XMT-1592
Undisclosed
SLC34A2
Auristatin F hydroxypropylamide (AF-HPA)
Cys-13 ADC linker
[167]
Zanidatamab zovodotin
Zanidatamab
HER2 ECD2; HER2 ECD4
ZD02044
Mc-PEG3-Val-Cit
[168]
Investigative
Click To Hide/Show 1958 ADC Related to This Stage
ADC Info ADC Name Antibody Antigen Payload Linker Ref
111In-DTPA-D2B-DAR2-MMAE
Anti-PSMA IgG1 mAb D2B
FOLH1
Monomethyl auristatin E
Mc-Val-Cit-PABC
[169]
111In-DTPA-D2B-DAR4-MMAE
Anti-PSMA IgG1 mAb D2B
FOLH1
Monomethyl auristatin E
Mc-Val-Cit-PABC
[169]
89Zr-DFO-T-DM1
Zr-labeled trastuzumab
ERBB2
Mertansine DM1
Undisclosed
[170]
Cetux Cys-vc-MMAE
Glyco-engineered cetuximab
EGFR
Monomethyl auristatin E
Mc-Val-Cit-PABC
[171]
Cetux Cys-vc-MMAE
Cetuximab
EGFR
Monomethyl auristatin E
Mc-Val-Cit-PABC
[171]
Cetux Fc/Fab-vc-MMAE
Glyco-engineered cetuximab Fc/Fab
EGFR
Monomethyl auristatin E
Mc-Val-Cit-PABC
[171]
Cetux Fc/Fab-vc-MMAE
Cetuximab (Fc/Fab labeled with Neu5NAz)
EGFR
Monomethyl auristatin E
Mc-Val-Cit-PABC
[171]
F105-SPDB-DM4
F105
ITGAV
Mertansine DM4
N-succinimidyl 4-(2-pyridyldithio) butanoate (SPDB)
[172]
F105-SSNPB-DM4
F105
ITGAV
Mertansine DM4
N-sulfosuccinimidyl-4-(5-nitro-2 pyridyldithio) butyrate (SSNPB)
[172]
h3G10.1.91-h3G10.A58 vc0101
h3G10.1.91-h3G10.A58
CXCR4
Auristatin 0101
Mc-Val-Cit-PABC
[173]
h3G10.1.91-h3G10.A58 vc0101
h3G10.1.91-h3G10.A58
CXCR4
Auristatin 0101
Mc-Val-Cit-PABC
[173]
h3G10.1.91-h3G10.A58 vcMMAD
h3G10.1.91-h3G10.A58
CXCR4
Monomethyl auristatin D
Mc-Val-Cit-PABC
[173]
h3G10.1.91-h3G10.A58 vcMMAD
h3G10.1.91-h3G10.A58
CXCR4
Monomethyl auristatin D
Mc-Val-Cit-PABC
[173]
h3G10.2.37-h3G10.A58 vc0101
h3G10.2.37-h3G10.A58
CXCR4
Auristatin 0101
Mc-Val-Cit-PABC
[173]
h3G10.2.37-h3G10.A58 vc0101
h3G10.2.37-h3G10.A58
CXCR4
Auristatin 0101
Mc-Val-Cit-PABC
[173]
h3G10.2.37-h3G10.A58 vcMMAD
h3G10.2.37-h3G10.A58
CXCR4
Monomethyl auristatin D
Mc-Val-Cit-PABC
[173]
h3G10.2.37-h3G10.A58 vcMMAD
h3G10.2.37-h3G10.A58
CXCR4
Monomethyl auristatin D
Mc-Val-Cit-PABC
[173]
h3G10.A57-h3G10.A58 vc0101
h3G10.A57-h3G10.A58
CXCR4
Auristatin 0101
Mc-Val-Cit-PABC
[173]
h3G10.A57-h3G10.A58 vc0101
h3G10.A57-h3G10.A58
CXCR4
Auristatin 0101
Mc-Val-Cit-PABC
[173]
h3G10.A57-h3G10.A58 vcMMAD
h3G10.A57-h3G10.A58
CXCR4
Monomethyl auristatin D
Mc-Val-Cit-PABC
[173]
h3G10.A57-h3G10.A58 vcMMAD
h3G10.A57-h3G10.A58
CXCR4
Monomethyl auristatin D
Mc-Val-Cit-PABC
[173]
Mil40-12B
Mil40
ERBB2
Monomethyl auristatin E
Maleamic methyl ester-based linker 12B
[174]
Mil40-12B
Mil40
ERBB2
Monomethyl auristatin E
Mc-Val-Cit-PABC
[174]
10D7-MMAE
Anti-CDCP1 mAb 10D7
CDCP1
Monomethyl auristatin E
Undisclosed
[175]
1131-MMAE
C-1131
CT83
Monomethyl auristatin E
Mc-Val-Cit-PABC
[176]
12A11-TG6-vcMMAD
12A11-TG6
CXCR4
Monomethyl auristatin D
Mc-Val-Cit-PABC
[173]
12G6 N297Q/S298N/Y300S-Mc-Val-Cit-PABC-MMAE
Anti-CD52 mAb 12G6 N297Q/S298N/Y300S
CD52
Monomethyl auristatin E
Mc-Val-Cit-PABC
[177]
12G6 S298N/T299A/Y300S-Mc-Val-Cit-PABC-MMAE
Anti-CD52 mAb 12G6 S298N/T299A/Y300S
CD52
Monomethyl auristatin E
Mc-Val-Cit-PABC
[177]
12G6 S298N/Y300S-Mc-Val-Cit-PABC-MMAE
Anti-CD52 mAb 12G6 S298N/Y300S
CD52
Monomethyl auristatin E
Mc-Val-Cit-PABC
[177]
12G6 WT-Mc-Val-Cit-PABC-MMAE
Anti-CD52 mAb 12G6 WT
CD52
Monomethyl auristatin E
Mc-Val-Cit-PABC
[177]
1711 (scFv)-SNAP-AuriF
1711/425 scFv-SNAP
EGFR
Auristatin F
BG based linker
[178]
1959-sss/DM4
Undisclosed
LGALS3BP
Mertansine DM4
Undisclosed
[179]
1959-SSS-DM3
Undisclosed
LGALS3BP
Maytansinoid DM3
Undisclosed
[180]
1C1-mcMMAF
Anti-EPHA2 mAb 1C1
EPHA2
Monomethyl auristatin F
Maleimido-caproyl
[181]
1F6-Asn- (D)Lys-AF
Anti-CD70 mAb IF6
CD70
Auristatin F
Mal-Asn-D-Lys
[182]
1F6-Asn- (D)Lys-AM
Anti-CD70 mAb IF6
CD70
Auristatin M
Mal-Asn-D-Lys
[182]
1F6-Asn- (D)Lys-AW
Anti-CD70 mAb IF6
CD70
L-Alanyl-L-tryptophan
Mal-Asn-D-Lys
[182]
1F6-Asn- (D)Lys-MMAF
Anti-CD70 mAb IF6
CD70
Monomethyl auristatin F
Mal-Asn-D-Lys
[182]
1F6-Asn-Lys-AF
Anti-CD70 mAb IF6
CD70
Auristatin F
Mal-Asn-Lys
[182]
1F6-Asp-Val-AF
Anti-CD70 mAb IF6
CD70
Auristatin F
Mal-Asp-Val
[182]
1F6-beta-Ala- (D)Asp-AF
Anti-CD70 mAb IF6
CD70
Auristatin F
Mal-bata-Ala-D-Asp
[182]
1F6-His-Val-AF
Anti-CD70 mAb IF6
CD70
Auristatin F
Mal-His-Val
[182]
1F6-Ile-Pro-AF
Anti-CD70 mAb IF6
CD70
Auristatin F
Mal-Ile-Pro
[182]
1F6-Ile-Val-AF
Anti-CD70 mAb IF6
CD70
Auristatin F
Mal-Ile-Val
[182]
1F6-Me3-Lys-Pro-AF
Anti-CD70 mAb IF6
CD70
Auristatin F
Mal-Me3Lys-Pro
[182]
1F6-Met- (D)Lys-AF
Anti-CD70 mAb IF6
CD70
Auristatin F
Mal-Met-D-Lys
[182]
1F6-Met- (D)Lys-AM
Anti-CD70 mAb IF6
CD70
Auristatin M
Mal-Met-D-Lys
[182]
1F6-Met- (D)Lys-AW
Anti-CD70 mAb IF6
CD70
L-Alanyl-L-tryptophan
Mal-Met-D-Lys
[182]
1F6-Met- (D)Lys-MMAF
Anti-CD70 mAb IF6
CD70
Monomethyl auristatin F
Mal-Met-D-Lys
[182]
1F6-Met-Lys-AF
Anti-CD70 mAb IF6
CD70
Auristatin F
Mal-Met-Lys
[182]
1F6-NorVal- (D)Asp-AF
Anti-CD70 mAb IF6
CD70
Auristatin F
Mal-NorVal-D-Asp
[182]
1F6-PhenylGly- (D)Lys-AF
Anti-CD70 mAb IF6
CD70
Auristatin F
Mal-PhenylGly-D-Lys
[182]
1F6-Pro- (D)Lys-AF
Anti-CD70 mAb IF6
CD70
Auristatin F
Mal-Pro-D-Lys
[182]
1F6-Val-Cit-PABC-MMAF
Anti-CD70 mAb IF6
CD70
Monomethyl auristatin F
Mal-Val-Cit-PABC
[182]
1F-Val-Cit-MMAE
Anit-TF mAb 1F
F3
Monomethyl auristatin E
Mc-Val-Cit-PABC
[183]
25A3-Val-Cit-MMAE
Anit-TF mAb 25A3
F3
Monomethyl auristatin E
Mc-Val-Cit-PABC
[183]
25A-Val-Cit-MMAE
Anit-TF mAb 25A
F3
Monomethyl auristatin E
Mc-Val-Cit-PABC
[183]
25G1-Val-Cit-MMAE
Anit-TF mAb 25G1
F3
Monomethyl auristatin E
Mc-Val-Cit-PABC
[183]
28E4-DM1
2.80E+05
MUC1
Mertansine DM1
N-succinimidyl 4-(2-pyridyldithio) pentanoate (SPP)
[184]
29E-Val-Cit-MMAE
Anit-TF mAb 29E
F3
Monomethyl auristatin E
Mc-Val-Cit-PABC
[183]
2C3 A114N-Mc-Val-Cit-PABC-MMAE
Anti-CD52 mAb 2C3 A114N
CD52
Monomethyl auristatin E
Mc-Val-Cit-PABC
[177]
2C3 NGT-Mc-Val-Cit-PABC-MMAE
Anti-CD52 mAb 2C3 NGT
CD52
Monomethyl auristatin E
Mc-Val-Cit-PABC
[177]
2C3 S298N Y300S-Mc-Val-Cit-PABC-MMAE
Anti-CD52 mAb 2C3 S298N Y300S
CD52
Monomethyl auristatin E
Mc-Val-Cit-PABC
[177]
2C3 S440N-Mc-Val-Cit-PABC-MMAE
Anti-CD52 mAb 2C3 S440N
CD52
Monomethyl auristatin E
Mc-Val-Cit-PABC
[177]
2C3 S442N-Mc-Val-Cit-PABC-MMAE
Anti-CD52 mAb 2C3 S442N
CD52
Monomethyl auristatin E
Mc-Val-Cit-PABC
[177]
2C3 WT-Mc-Val-Cit-PABC-MMAE
Anti-CD52 mAb 2C3 WT
CD52
Monomethyl auristatin E
Mc-Val-Cit-PABC
[177]
2C3 Y436S-Mc-Val-Cit-PABC-MMAE
Anti-CD52 mAb 2C3 Y436S
CD52
Monomethyl auristatin E
Mc-Val-Cit-PABC
[177]
2G10 RED-106 maytansine 2
Anti-PLAUR mAb 2G10
PLAUR
Mertansine DM1
RED-106
[185]
2G10 RED-106 maytansine 4
Anti-PLAUR mAb 2G10
PLAUR
Mertansine DM1
RED-106
[185]
2G10 RED-244 MMAE 2
Anti-PLAUR mAb 2G10
PLAUR
Monomethyl auristatin E
RED-244
[185]
2G10 RED-244 MMAE 4
Anti-PLAUR mAb 2G10
PLAUR
Monomethyl auristatin E
RED-244
[185]
2G10 RED-388 MMAE 4
Anti-PLAUR mAb 2G10
PLAUR
Monomethyl auristatin E
RED-388
[185]
2G10 RED-412 MMAE 4
Anti-PLAUR mAb 2G10
PLAUR
Monomethyl auristatin E
RED-412
[185]
2G10 RED-425 maytansine 4
Anti-PLAUR mAb 2G10
PLAUR
Mertansine DM1
RED-425
[185]
2G10 RED-426 MMAE 4
Anti-PLAUR mAb 2G10
PLAUR
Monomethyl auristatin E
RED-426
[185]
2G10 RED-432 maytansine 4
Anti-PLAUR mAb 2G10
PLAUR
Mertansine DM1
RED-432
[185]
2G4-DM1
Anti-KIT mAb 2G4
KIT
Mertansine DM1
Undisclosed
[186]
2H9-A121C-BMPEO-DM1
Anti-HER2 antibody 2H9-A121C
ERBB2
Maytansinoid DM1
2H9-A121C-BMPEO-DM1 linker
[187]
33B7-Saporin
Anti-PTGFRN mAb 33B7
PTGFRN
Saporin
Undisclosed
[188]
39A-Val-Cit-MMAE
Anit-TF mAb 39A
F3
Monomethyl auristatin E
Mc-Val-Cit-PABC
[183]
3A5-55 ADC
Anti-MUC16 Anti-ody 3A5
MUC16
Maytansine derivative 55
Mal-EBE-Mal
[189]
3A5-56 ADC
Anti-MUC16 Anti-ody 3A5
MUC16
Maytansine derivative 56
Mal-EBE-Mal
[189]
3A5-57 ADC
Anti-MUC16 Anti-ody 3A5
MUC16
Maytansine derivative 57
Maleimido-caproyl
[189]
3A5-mc-VC-PAB-MMAE
Anti-MUC16 Anti-ody 3A5
MUC16
Monomethyl auristatin E
Mc-Val-Cit-PABC
[189]
3G10-TG6-vc0101
3G10-TG6
CXCR4
Auristatin 0101
Mc-Val-Cit-PABC
[173]
3G10-TG6-vcMMAD
3G10-TG6
CXCR4
Monomethyl auristatin D
Mc-Val-Cit-PABC
[173]
40H3-MCVCPAB-MMAE
Anti-EGFR mAb 40H3
EGFR
Monomethyl auristatin E
Mc-Val-Cit-PABC
[190]
40H3-SMCC-DM1
Anti-EGFR mAb 40H3
EGFR
Mertansine DM1
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
[190]
43B1-Val-Cit-MMAE
Anit-TF mAb 43B1
F3
Monomethyl auristatin E
Mc-Val-Cit-PABC
[183]
43D7-Val-Cit-MMAE
Anit-TF mAb 43D7
F3
Monomethyl auristatin E
Mc-Val-Cit-PABC
[183]
43Ea-Val-Cit-MMAE
Anit-TF mAb 43Ea
F3
Monomethyl auristatin E
Mc-Val-Cit-PABC
[183]
4C9-DM1
Anti-KIT mAb 4C9
KIT
Mertansine DM1
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
[191]
4D5-AF (CUAAC)
Anti-HER2/neu mAb 4D5
ERBB2
Auristatin F
N6-(2-azidoethoxy)carbonyl-L-lysine
[192]
54E-Val-Cit-MMAE
Anit-TF mAb 54E
F3
Monomethyl auristatin E
Mc-Val-Cit-PABC
[183]
5E3-emtansine
Anti-SEMA4A mAb 5E3
SEMA4A
Mertansine DM1
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
[193]
5E3-Saporin ADC
Anti-SEMA4A mAb 5E3
SEMA4A
Saporin
Undisclosed
[193]
5E3-vedotin
Anti-SEMA4A mAb 5E3
SEMA4A
Monomethyl auristatin E
Mc-Val-Cit-PABC
[193]
6B6-TG6-vc0101
6B6-TG6
CXCR4
Auristatin 0101
Mc-Val-Cit-PABC
[173]
6B6-TG6-vcMMAD
6B6-TG6
CXCR4
Monomethyl auristatin D
Mc-Val-Cit-PABC
[173]
7H5-Val-Cit-MMAE
Anti-TIP1 mAb 7H5
TAX1BP3
Monomethyl auristatin E
Mc-Val-Cit-PABC
[194]
A114N NNAS-Mc-Val-Cit-PABC-MMAE
Anti-HER2 mAb A114N NNAS
ERBB2
Monomethyl auristatin E
Mc-Val-Cit-PABC
[177]
A114N-Mc-Val-Cit-PABC-MMAE
Anti-HER2 mAb A114N
ERBB2
Monomethyl auristatin E
Mc-Val-Cit-PABC
[177]
A5/158-vc-MMAE
A5/158
MRC2
Monomethyl auristatin E
Mc-Val-Cit-PABC
[195]
A7R-ADC-MMAE
Anti-IL7R mAb A7R
IL7R
Monomethyl auristatin E
Mal-PEG12-Val-Cit-PABC
[196]
AAJ8D6-D07-Val-Cit-PAB-MMAE
AAJ8D6
MET
Monomethyl auristatin E
Mc-Val-Cit-PABC
[197]
AAJ8D6-Mc-Val-Cit-MMAE
AAJ8D6
MET
Monomethyl auristatin E
Mc-Val-Cit-PABC
[197]
AAJ8D6-PY-Val-Cit-MMAE
AAJ8D6
MET
Monomethyl auristatin E
PY-VC-PABC
[197]
Ab1-mcMMAF
Anti-EGFR Ab1
EGFR
Monomethyl auristatin F
Maleimido-caproyl
[198]
AB-3A4-Val-Cit-MMAE
Anti-KAAG1 mAb AB-3A4
KAAG1
Monomethyl auristatin E
Mc-Val-Cit-PABC
[199]
Ab3-mcMMAF
Anti-EGFR Ab3
EGFR
Monomethyl auristatin F
Maleimido-caproyl
[198]
AbA-mcMMAE
Anti-EGFR AbA
EGFR
Monomethyl auristatin E
Maleimido-caproyl
[198]
AbA-vcMMAE
Anti-EGFR AbA
EGFR
Monomethyl auristatin E
Mc-Val-Cit-PABC
[198]
ABT-700-Mc-Val-Cit-MMAE
Telisotuzumab
MET
Monomethyl auristatin E
Mc-Val-Cit-PABC
[197]
Adalimumab-Compound 17
Adalimumab
TNF
Mertansine DM4
Adalimumab-Compound 17 linker
[200]
Adalimumab-Compound 25
Adalimumab
TNF
Monomethyl auristatin E
Adalimumab-Compound 25 linker
[200]
Adalimumab-Compound 31
Adalimumab
TNF
Auristatin 0101
Adalimumab-Compound 31 linker
[200]
Adalimumab-Compound 36
Adalimumab
TNF
Monomethyl auristatin E
Adalimumab-Compound 36 linker
[200]
Adalimumab-Compound 55
Adalimumab
TNF
Mertansine DM1
Adalimumab-Compound 55 linker
[200]
Adalimumab-Compound 59
Adalimumab
TNF
Mertansine DM4
Adalimumab-Compound 59 linker
[200]
Adalimumab-Compound 64
Adalimumab
TNF
Monomethyl auristatin E
Adalimumab-Compound 64 linker
[200]
Adalimumab-Compound 69
Adalimumab
TNF
Monomethyl auristatin E
Adalimumab-Compound 69 linker
[200]
Adalimumab-Compound 75
Adalimumab
TNF
Monomethyl auristatin E
Adalimumab-Compound 75 linker
[200]
Adalimumab-Compound 76
Adalimumab
TNF
Monomethyl auristatin E
Adalimumab-Compound 76 linker
[200]
Adalimumab-Compound 77
Adalimumab
TNF
Mertansine DM1
Adalimumab-Compound 77 linker
[200]
Adalimumab-Compound 78
Adalimumab
TNF
Auristatin 0101
Adalimumab-Compound 78 linker
[200]
Adalimumab-Compound 79
Adalimumab
TNF
Auristatin 0101
Adalimumab-Compound 79 linker
[200]
Adalimumab-Compound 80
Adalimumab
TNF
Mertansine DM4
Adalimumab-Compound 80 linker
[200]
Adalimumab-Compound 9
Adalimumab
TNF
Mertansine DM1
Adalimumab-Compound 9 linker
[200]
ADAPT6-ABD-mcDM1
ADAPT6-ABD
ERBB2
Mertansine DM1
Maleimidocaproyl (Ser3-Gly)3
[201]
ADC Mil40-6
Mil40
ERBB2
Monomethyl auristatin E
Silyl ether-based linker
[202]
ADC MMAE/F 2+2
Trastuzumab N297A
ERBB2
Monomethyl auristatin E+Monomethyl auristatin F
DBCO-PEG3-Glu-Val-Cit-PABC; TCO-PEG3-Glu-Val-Cit-PABC
[203]
ADC MMAE/F 2+4
Trastuzumab N297A
ERBB2
Monomethyl auristatin E+Monomethyl auristatin F
DBCO-PEG3-Glu-Val-Cit-PABC; TCO-PEG3-Glu-Val-Cit-PABC
[203]
ADC MMAE/F 4+2
Trastuzumab N297A
ERBB2
Monomethyl auristatin E+Monomethyl auristatin F
DBCO-PEG3-Glu-Val-Cit-PABC; TCO-PEG3-Glu-Val-Cit-PABC
[203]
ADC Trast-10
Trastuzumab
ERBB2
Monomethyl auristatin E
Bis-BCN-modified Val-Cit-PABC linker 10
[204]
ADC Trast-7
Trastuzumab
ERBB2
Monomethyl auristatin E
Undisclosed
[204]
ADC14-0810
Cetuximab (LC) G7-CVIM
EGFR
Monomethyl auristatin F
ADC14-0810 linker
[205]
ADC-AVP-04
AVP04
Undisclosed
Monomethyl auristatin E
Maleimide-functionalized TCO
[206]
Adcitmer
Trastuzumab
ERBB2
Monomethyl auristatin E
Pyridino-caproic-Val-Cit-PABC
[207]
AFM-11-2i
AFM-11
CD19
Monomethyl auristatin F
AFM-11-2i linker
[208]
AFM-11-3i
AFM-11
CD19
Monomethyl auristatin F
AFM-11-3i linker
[208]
AFM-11-4i
AFM-11
CD19
Monomethyl auristatin F
AFM-11-4i linker
[208]
AFM-11-6e
AFM-11
CD19
Monomethyl auristatin E
AFM-11-6e linker
[208]
AFM-12-2i
AFM-12
CD19
Monomethyl auristatin F
AFM-12-2i linker
[208]
AFM-12-3i
AFM-12
CD19
Monomethyl auristatin F
AFM-12-3i linker
[208]
AFM-12-4i
AFM-12
CD19
Monomethyl auristatin F
AFM-12-4i linker
[208]
AFM-12-6e
AFM-12
CD19
Monomethyl auristatin E
AFM-12-6e linker
[208]
AG 02 saporin conjugate
Anti-CSP-1 mAb AG02
Undisclosed
Saporin
Undisclosed
[209]
ALA12-Val-Cit-MMAE
Anti-MSLN IgG1-ALA12
MSLN
Monomethyl auristatin E
Mc-Val-Cit-PABC
[210]
Alb-DMBA-SIL-MMAE
Alb
ALB
Monomethyl auristatin E
DMBA-SIL
[211]
Alemtuzumab-Compound 17
Alemtuzumab
CD52
Mertansine DM4
Alemtuzumab-Compound 17 linker
[200]
Alemtuzumab-Compound 25
Alemtuzumab
CD52
Monomethyl auristatin E
Alemtuzumab-Compound 25 linker
[200]
Alemtuzumab-Compound 31
Alemtuzumab
CD52
Auristatin 0101
Alemtuzumab-Compound 31 linker
[200]
Alemtuzumab-Compound 36
Alemtuzumab
CD52
Monomethyl auristatin E
Alemtuzumab-Compound 36 linker
[200]
Alemtuzumab-Compound 55
Alemtuzumab
CD52
Mertansine DM1
Alemtuzumab-Compound 55 linker
[200]
Alemtuzumab-Compound 59
Alemtuzumab
CD52
Mertansine DM4
Alemtuzumab-Compound 59 linker
[200]
Alemtuzumab-Compound 64
Alemtuzumab
CD52
Monomethyl auristatin E
Alemtuzumab-Compound 64 linker
[200]
Alemtuzumab-Compound 69
Alemtuzumab
CD52
Monomethyl auristatin E
Alemtuzumab-Compound 69 linker
[200]
Alemtuzumab-Compound 75
Alemtuzumab
CD52
Monomethyl auristatin E
Alemtuzumab-Compound 75 linker
[200]
Alemtuzumab-Compound 76
Alemtuzumab
CD52
Monomethyl auristatin E
Alemtuzumab-Compound 76 linker
[200]
Alemtuzumab-Compound 77
Alemtuzumab
CD52
Mertansine DM1
Alemtuzumab-Compound 77 linker
[200]
Alemtuzumab-Compound 78
Alemtuzumab
CD52
Auristatin 0101
Alemtuzumab-Compound 78 linker
[200]
Alemtuzumab-Compound 79
Alemtuzumab
CD52
Auristatin 0101
Alemtuzumab-Compound 79 linker
[200]
Alemtuzumab-Compound 80
Alemtuzumab
CD52
Mertansine DM4
Alemtuzumab-Compound 80 linker
[200]
Alemtuzumab-Compound 9
Alemtuzumab
CD52
Mertansine DM1
Alemtuzumab-Compound 9 linker
[200]
Alpha-CD30-7
Anti-CD30 mAb
TNFRSF8
Tubulysin 7
Glucuronide quaternary ammonium linker 7
[212]
Alpha-CD30-8
Anti-CD30 mAb
TNFRSF8
Tubulysin 8
Glucuronide quaternary ammonium linker 8
[212]
Alpha-CD30-9
Anti-CD30 mAb
TNFRSF8
Tubulysin 9
Glucuronide quaternary ammonium linker 9
[212]
Alpha-CLDN-VC0101
Undisclosed
CLDN18.2
Auristatin 0101
Mc-Val-Cit-PABC
[213]
Amatuximab-Compound 17
Amatuximab
MSLN
Mertansine DM4
Amatuximab-Compound 17 linker
[200]
Amatuximab-Compound 25
Amatuximab
MSLN
Monomethyl auristatin E
Amatuximab-Compound 25 linker
[200]
Amatuximab-Compound 31
Amatuximab
MSLN
Auristatin 0101
Amatuximab-Compound 31 linker
[200]
Amatuximab-Compound 36
Amatuximab
MSLN
Monomethyl auristatin E
Amatuximab-Compound 36 linker
[200]
Amatuximab-Compound 55
Amatuximab
MSLN
Mertansine DM1
Amatuximab-Compound 55 linker
[200]
Amatuximab-Compound 59
Amatuximab
MSLN
Mertansine DM4
Amatuximab-Compound 59 linker
[200]
Amatuximab-Compound 64
Amatuximab
MSLN
Monomethyl auristatin E
Amatuximab-Compound 64 linker
[200]
Amatuximab-Compound 69
Amatuximab
MSLN
Monomethyl auristatin E
Amatuximab-Compound 69 linker
[200]
Amatuximab-Compound 75
Amatuximab
MSLN
Monomethyl auristatin E
Amatuximab-Compound 75 linker
[200]
Amatuximab-Compound 76
Amatuximab
MSLN
Monomethyl auristatin E
Amatuximab-Compound 76 linker
[200]
Amatuximab-Compound 77
Amatuximab
MSLN
Mertansine DM1
Amatuximab-Compound 77 linker
[200]
Amatuximab-Compound 78
Amatuximab
MSLN
Auristatin 0101
Amatuximab-Compound 78 linker
[200]
Amatuximab-Compound 79
Amatuximab
MSLN
Auristatin 0101
Amatuximab-Compound 79 linker
[200]
Amatuximab-Compound 80
Amatuximab
MSLN
Mertansine DM4
Amatuximab-Compound 80 linker
[200]
Amatuximab-Compound 9
Amatuximab
MSLN
Mertansine DM1
Amatuximab-Compound 9 linker
[200]
An2-anti-HER2-Doxetaxel
ANG4043
ERBB2
Docetaxel
Undisclosed
[214]
Anti-alpha10-SAP
Anti-integrin alpha10 mAb
ITGA10
Saporin
Undisclosed
[215]
Anti-BCMA 15B2GL-mcMMAF
Anti-BCMA antibody 15B2GL
TNFRSF17
Monomethyl auristatin F
Maleimido-caproyl
[216]
Anti-BCMA 15B2WT-mcMMAF
Anti-BCMA antibody 15B2WT
TNFRSF17
Monomethyl auristatin F
Maleimido-caproyl
[216]
Anti-BCMA I09-mcMMAF
Anti-BCMA antibody I09
TNFRSF17
Monomethyl auristatin F
Maleimido-caproyl
[216]
Anti-BCMA J6M0-mcMMAF
Anti-BCMA antibody J6M0
TNFRSF17
Monomethyl auristatin F
Maleimido-caproyl
[216]
Anti-BCMA L15-mcMMAF
Anti-BCMA antibody L15
TNFRSF17
Monomethyl auristatin F
Maleimido-caproyl
[216]
Anti-BCMA M02-mcMMAF
Anti-BCMA antibody M02
TNFRSF17
Monomethyl auristatin F
Maleimido-caproyl
[216]
Anti-BCMA N22-mcMMAF
Anti-BCMA antibody N22
TNFRSF17
Monomethyl auristatin F
Maleimido-caproyl
[216]
Anti-BCMA P10-mcMMAF
Anti-BCMA antibody P10
TNFRSF17
Monomethyl auristatin F
Maleimido-caproyl
[216]
Anti-CD19(LC)-G7VIM-2i
DI-B4-(LC)-GGGGGGG-CVIM
CD19
Monomethyl auristatin F
Anti-CD19(LC)-G7VIM-2i linker
[208]
Anti-CD19(LC)-G7VIM-3i
DI-B4-(LC)-GGGGGGG-CVIM
CD19
Monomethyl auristatin F
Anti-CD19(LC)-G7VIM-3i linker
[208]
Anti-CD19(LC)-G7VIM-4i
DI-B4-(LC)-GGGGGGG-CVIM
CD19
Monomethyl auristatin F
Anti-CD19(LC)-G7VIM-4i linker
[208]
Anti-CD19(LC)-G7VIM-6e
DI-B4-(LC)-GGGGGGG-CVIM
CD19
Monomethyl auristatin E
Anti-CD19(LC)-G7VIM-6e linker
[208]
Anti-CD22-K149C-DM1
Anti-CD22 Anti-ody (LC-K149C)
CD22
Mertansine DM1
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
[217]
Anti-CD22-K149C-MBT-DM4
Anti-CD22 Anti-ody (LC-K149C)
CD22
Mertansine DM4
MBT
[217]
Anti-CD22-K149C-MPEO-DM1
Anti-CD22 Anti-ody (LC-K149C)
CD22
Mertansine DM1
MPEO
[217]
Anti-CD22-SPDB-DM4
Anti-CD22 Anti-ody (LC-K149C)
CD22
Mertansine DM4
N-succinimidyl 4-(2-pyridyldithio) butanoate (SPDB)
[217]
Anti-CD30 monoclonal antibody-saporin conjugate
Anti-CD30 mAb Ber-H2
TNFRSF8
Saporin
Undisclosed
[218]
Anti-CD38 IT OKT10-SAPORIN
Undisclosed
CD38
Saporin
Undisclosed
[219]
Anti-CD47 mAb (IgG2b/kappa)-DM1
Anti-CD47 mAb (IgG2b/kappa)-
CD47
Mertansine DM1
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
[220]
Anti-CD59 mAb-Compound 17
Anti-CD59 mAb
CD59
Mertansine DM4
Anti-CD59 mAb-Compound 17 linker
[200]
Anti-CD59 mAb-Compound 25
Anti-CD59 mAb
CD59
Monomethyl auristatin E
Anti-CD59 mAb-Compound 25 linker
[200]
Anti-CD59 mAb-Compound 31
Anti-CD59 mAb
CD59
Auristatin 0101
Anti-CD59 mAb-Compound 31 linker
[200]
Anti-CD59 mAb-Compound 36
Anti-CD59 mAb
CD59
Monomethyl auristatin E
Anti-CD59 mAb-Compound 36 linker
[200]
Anti-CD59 mAb-Compound 55
Anti-CD59 mAb
CD59
Mertansine DM1
Anti-CD59 mAb-Compound 55 linker
[200]
Anti-CD59 mAb-Compound 59
Anti-CD59 mAb
CD59
Mertansine DM4
Anti-CD59 mAb-Compound 59 linker
[200]
Anti-CD59 mAb-Compound 64
Anti-CD59 mAb
CD59
Monomethyl auristatin E
Anti-CD59 mAb-Compound 64 linker
[200]
Anti-CD59 mAb-Compound 69
Anti-CD59 mAb
CD59
Monomethyl auristatin E
Anti-CD59 mAb-Compound 69 linker
[200]
Anti-CD59 mAb-Compound 75
Anti-CD59 mAb
CD59
Monomethyl auristatin E
Anti-CD59 mAb-Compound 75 linker
[200]
Anti-CD59 mAb-Compound 76
Anti-CD59 mAb
CD59
Monomethyl auristatin E
Anti-CD59 mAb-Compound 76 linker
[200]
Anti-CD59 mAb-Compound 77
Anti-CD59 mAb
CD59
Mertansine DM1
Anti-CD59 mAb-Compound 77 linker
[200]
Anti-CD59 mAb-Compound 78
Anti-CD59 mAb
CD59
Auristatin 0101
Anti-CD59 mAb-Compound 78 linker
[200]
Anti-CD59 mAb-Compound 79
Anti-CD59 mAb
CD59
Auristatin 0101
Anti-CD59 mAb-Compound 79 linker
[200]
Anti-CD59 mAb-Compound 80
Anti-CD59 mAb
CD59
Mertansine DM4
Anti-CD59 mAb-Compound 80 linker
[200]
Anti-CD59 mAb-Compound 9
Anti-CD59 mAb
CD59
Mertansine DM1
Anti-CD59 mAb-Compound 9 linker
[200]
Anti-CD7 MMAE ADC
Human Anti-CD7 mAb IgG1
CD7
Monomethyl auristatin E
PermaLink-PEG4-Val-Cit-PAB
[221]
Anti-CXCR4 ADC 381
Anti-CXCR4 mAb m17
CXCR4
Auristatin 0101
AcLys-Val-Cit-PABC
[222]
Anti-CXCR4 ADC 510
Anti-CXCR4 mAb m17
CXCR4
Aur0131
AmPEG6C2
[222]
Anti-CXCR4 ADC 513
Anti-CXCR4 mAb m17
CXCR4
Aur0131
AmPEG6C2
[222]
Anti-CXCR4 ADC 518
Anti-CXCR4 mAb m17
CXCR4
Auristatin 0101
AcLys-Val-Cit-PABC
[222]
Anti-CXCR4 ADC 519
Anti-CXCR4 mAb m17
CXCR4
Auristatin 0101
AcLys-Val-Cit-PABC
[222]
Anti-CXCR4 ADC 553
Anti-CXCR4 mAb h17-NA
CXCR4
Auristatin 0101
AcLys-Val-Cit-PABC
[222]
Anti-CXCR4 ADC 554
Anti-CXCR4 mAb h17-NS
CXCR4
Auristatin 0101
AcLys-Val-Cit-PABC
[222]
Anti-CXCR4 ADC 555
Anti-CXCR4 mAb h17-NQ
CXCR4
Auristatin 0101
AcLys-Val-Cit-PABC
[222]
Anti-CXCR4 ADC 556
Anti-CXCR4 mAb h17-NV.TS
CXCR4
Auristatin 0101
AcLys-Val-Cit-PABC
[222]
Anti-CXCR4 ADC 669
Anti-CXCR4 mAb h17-NQ
CXCR4
Aur0131
AmPEG6C2
[222]
Anti-CXCR4 ADC 670
Anti-CXCR4 mAb h17-NV.TS
CXCR4
Aur0131
AmPEG6C2
[222]
Anti-CXCR4 ADC 671
Anti-CXCR4 mAb h17-NA
CXCR4
Aur0131
AmPEG6C2
[222]
Anti-CXCR4 ADC 672
Anti-CXCR4 mAb h17-NS
CXCR4
Aur0131
AmPEG6C2
[222]
Anti-CXCR4 ADC 711
Anti-CXCR4 mAb h17-NA
CXCR4
Aur0131
AmPEG6C2
[222]
Anti-CXCR4 ADC 712
Anti-CXCR4 mAb h17-NA
CXCR4
Aur0131
AmPEG6C2
[222]
Anti-CXCR4 ADC 713
Anti-CXCR4 mAb h17-NV.TS
CXCR4
Aur0131
AmPEG6C2
[222]
Anti-CXCR4 ADC 714
Anti-CXCR4 mAb h17-NV.TS
CXCR4
Aur0131
AmPEG6C2
[222]
Anti-DOG1-DM4-ADC
Anti-DOG1 mAb
ANO1
Mertansine DM4
N-succinimidyl 4-(2-pyridyldithio) butanoate (SPDB)
[223]
Anti-EGFR-PEG4-Mal-DM1
Anti-EGFR mAb rat IgG2a
EGFR
Mertansine DM1
PEG4-Mal
[224]
Anti-EGFR-Sulfo-SMCC-DM1
Anti-EGFR mAb
EGFR
Mertansine DM1
Sulfo-SMCC
[225]
Anti-endosialin-Mc-Val-Cit-PABC-MMAE
Undisclosed
CD248
Monomethyl auristatin E
Mc-Val-Cit-PABC
[226]
Anti-FAP B11-AO-Cys-MC-VC-PABC-MMAE
Anti-FAP mAb B11
FAP
Monomethyl auristatin E
Anti-FAP B11-AO-Cys-MC-VC-PABC-MMAE linker
[177]
Anti-FAP B11-MC-VC-PABC-MMAE
Anti-FAP mAb B11
FAP
Monomethyl auristatin E
Anti-FAP B11-MC-VC-PABC-MMAE linker
[177]
Anti-FcRL5-Mc-vcPAB-MMAE
Anti-FcRL5 mAb
FCRL5
Monomethyl auristatin E
Mc-Val-Cit-PABC
[227]
Anti-FcRL5-SPDB-DM4
Anti-FcRL5 mAb
FCRL5
Mertansine DM4
N-succinimidyl 4-(2-pyridyldithio) butanoate (SPDB)
[228]
Anti-FGFR2 mAb-10164 CX1-1-DM1
Anti-FGFR2 mAb 10164
FGFR2
Mertansine DM1
2,5-Dioxopyrrolidin-1-yl 17-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)-5,8,11,14-tetraazaheptadecan-1-oate (CX1-1)
[229]
Anti-FGFR2 mAb-10164 SMCC-DM1
Anti-FGFR2 mAb 10164
FGFR2
Mertansine DM1
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
[229]
Anti-FGFR2 mAb-10164 SPDB-DM4
Anti-FGFR2 mAb 10164
FGFR2
Mertansine DM4
N-succinimidyl 4-(2-pyridyldithio) butanoate (SPDB)
[229]
Anti-FGFR2 mAb-10164 SPDP-DM1
Anti-FGFR2 mAb 10164
FGFR2
Mertansine DM1
N-succinimidyl 3-(2-pyridyldithio) propionate (SPDP)
[229]
Anti-FGFR2 mAb-10164 SPP-DM1
Anti-FGFR2 mAb 10164
FGFR2
Mertansine DM1
N-succinimidyl 4-(2-pyridyldithio) pentanoate (SPP)
[229]
Anti-FGFR2 mAb-10164 SSNPP-DM3
Anti-FGFR2 mAb 10164
FGFR2
Maytansinoid DM3
Sulfosuccinimidyl-N-succinimidyl-4-(5-nitro-2-pyridyldithio) pentanoate (SSNPP)
[229]
Anti-FGFR2 mAb-10164 Sulfo-SPDB-DM4
Anti-FGFR2 mAb 10164
FGFR2
Mertansine DM4
Sulfo-SPDB
[229]
Anti-FGFR2 mAb-10220 CX1-1-DM1
Anti-FGFR2 mAb 10220
FGFR2
Mertansine DM1
2,5-Dioxopyrrolidin-1-yl 17-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)-5,8,11,14-tetraazaheptadecan-1-oate (CX1-1)
[229]
Anti-FGFR2 mAb-10220 SMCC-DM1
Anti-FGFR2 mAb 10220
FGFR2
Mertansine DM1
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
[229]
Anti-FGFR2 mAb-10220 SPDB-DM4
Anti-FGFR2 mAb 10220
FGFR2
Mertansine DM4
N-succinimidyl 4-(2-pyridyldithio) butanoate (SPDB)
[229]
Anti-FGFR2 mAb-10220 SPDP-DM1
Anti-FGFR2 mAb 10220
FGFR2
Mertansine DM1
N-succinimidyl 3-(2-pyridyldithio) propionate (SPDP)
[229]
Anti-FGFR2 mAb-10220 SPP-DM1
Anti-FGFR2 mAb 10220
FGFR2
Mertansine DM1
N-succinimidyl 4-(2-pyridyldithio) pentanoate (SPP)
[229]
Anti-FGFR2 mAb-10220 SSNPP-DM3
Anti-FGFR2 mAb 10220
FGFR2
Maytansinoid DM3
Sulfosuccinimidyl-N-succinimidyl-4-(5-nitro-2-pyridyldithio) pentanoate (SSNPP)
[229]
Anti-FGFR2 mAb-10220 Sulfo-SPDB-DM4
Anti-FGFR2 mAb 10220
FGFR2
Mertansine DM4
Sulfo-SPDB
[229]
Anti-FGFR2 mAb-10846 CX1-1-DM1
Anti-FGFR2 mAb 10846
FGFR2
Mertansine DM1
2,5-Dioxopyrrolidin-1-yl 17-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)-5,8,11,14-tetraazaheptadecan-1-oate (CX1-1)
[229]
Anti-FGFR2 mAb-10846 SMCC-DM1
Anti-FGFR2 mAb 10846
FGFR2
Mertansine DM1
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
[229]
Anti-FGFR2 mAb-10846 SPDB-DM4
Anti-FGFR2 mAb 10846
FGFR2
Mertansine DM4
N-succinimidyl 4-(2-pyridyldithio) butanoate (SPDB)
[229]
Anti-FGFR2 mAb-10846 SPDP-DM1
Anti-FGFR2 mAb 10846
FGFR2
Mertansine DM1
N-succinimidyl 3-(2-pyridyldithio) propionate (SPDP)
[229]
Anti-FGFR2 mAb-10846 SPP-DM1
Anti-FGFR2 mAb 10846
FGFR2
Mertansine DM1
N-succinimidyl 4-(2-pyridyldithio) pentanoate (SPP)
[229]
Anti-FGFR2 mAb-10846 SSNPP-DM3
Anti-FGFR2 mAb 10846
FGFR2
Maytansinoid DM3
Sulfosuccinimidyl-N-succinimidyl-4-(5-nitro-2-pyridyldithio) pentanoate (SSNPP)
[229]
Anti-FGFR2 mAb-10846 Sulfo-SPDB-DM4
Anti-FGFR2 mAb 10846
FGFR2
Mertansine DM4
Sulfo-SPDB
[229]
Anti-FGFR2 mAb-11723 CX1-1-DM1
Anti-FGFR2 mAb 11723
FGFR2
Mertansine DM1
2,5-Dioxopyrrolidin-1-yl 17-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)-5,8,11,14-tetraazaheptadecan-1-oate (CX1-1)
[229]
Anti-FGFR2 mAb-11723 SMCC-DM1
Anti-FGFR2 mAb 11723
FGFR2
Mertansine DM1
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
[229]
Anti-FGFR2 mAb-11723 SPDB-DM4
Anti-FGFR2 mAb 11723
FGFR2
Mertansine DM4
N-succinimidyl 4-(2-pyridyldithio) butanoate (SPDB)
[229]
Anti-FGFR2 mAb-11723 SPDP-DM1
Anti-FGFR2 mAb 11723
FGFR2
Mertansine DM1
N-succinimidyl 3-(2-pyridyldithio) propionate (SPDP)
[229]
Anti-FGFR2 mAb-11723 SPP-DM1
Anti-FGFR2 mAb 11723
FGFR2
Mertansine DM1
N-succinimidyl 4-(2-pyridyldithio) pentanoate (SPP)
[229]
Anti-FGFR2 mAb-11723 SSNPP-DM3
Anti-FGFR2 mAb 11723
FGFR2
Maytansinoid DM3
Sulfosuccinimidyl-N-succinimidyl-4-(5-nitro-2-pyridyldithio) pentanoate (SSNPP)
[229]
Anti-FGFR2 mAb-11723 Sulfo-SPDB-DM4
Anti-FGFR2 mAb 11723
FGFR2
Mertansine DM4
Sulfo-SPDB
[229]
Anti-FGFR2 mAb-11725 CX1-1-DM1
Anti-FGFR2 mAb 11725
FGFR2
Mertansine DM1
2,5-Dioxopyrrolidin-1-yl 17-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)-5,8,11,14-tetraazaheptadecan-1-oate (CX1-1)
[229]
Anti-FGFR2 mAb-11725 SMCC-DM1
Anti-FGFR2 mAb 11725
FGFR2
Mertansine DM1
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
[229]
Anti-FGFR2 mAb-11725 SPDB-DM4
Anti-FGFR2 mAb 11725
FGFR2
Mertansine DM4
N-succinimidyl 4-(2-pyridyldithio) butanoate (SPDB)
[229]
Anti-FGFR2 mAb-11725 SPDP-DM1
Anti-FGFR2 mAb 11725
FGFR2
Mertansine DM1
N-succinimidyl 3-(2-pyridyldithio) propionate (SPDP)
[229]
Anti-FGFR2 mAb-11725 SPP-DM1
Anti-FGFR2 mAb 11725
FGFR2
Mertansine DM1
N-succinimidyl 4-(2-pyridyldithio) pentanoate (SPP)
[229]
Anti-FGFR2 mAb-11725 SSNPP-DM3
Anti-FGFR2 mAb 11725
FGFR2
Maytansinoid DM3
Sulfosuccinimidyl-N-succinimidyl-4-(5-nitro-2-pyridyldithio) pentanoate (SSNPP)
[229]
Anti-FGFR2 mAb-11725 Sulfo-SPDB-DM4
Anti-FGFR2 mAb 11725
FGFR2
Mertansine DM4
Sulfo-SPDB
[229]
Anti-FGFR2 mAb-12433 CX1-1-DM1
Anti-FGFR2 mAb 12433
FGFR2
Mertansine DM1
2,5-Dioxopyrrolidin-1-yl 17-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)-5,8,11,14-tetraazaheptadecan-1-oate (CX1-1)
[229]
Anti-FGFR2 mAb-12433 SMCC-DM1
Anti-FGFR2 mAb 12433
FGFR2
Mertansine DM1
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
[229]
Anti-FGFR2 mAb-12433 SPDB-DM4
Anti-FGFR2 mAb 12433
FGFR2
Mertansine DM4
N-succinimidyl 4-(2-pyridyldithio) butanoate (SPDB)
[229]
Anti-FGFR2 mAb-12433 SPDP-DM1
Anti-FGFR2 mAb 12433
FGFR2
Mertansine DM1
N-succinimidyl 3-(2-pyridyldithio) propionate (SPDP)
[229]
Anti-FGFR2 mAb-12433 SPP-DM1
Anti-FGFR2 mAb 12433
FGFR2
Mertansine DM1
N-succinimidyl 4-(2-pyridyldithio) pentanoate (SPP)
[229]
Anti-FGFR2 mAb-12433 SSNPP-DM3
Anti-FGFR2 mAb 12433
FGFR2
Maytansinoid DM3
Sulfosuccinimidyl-N-succinimidyl-4-(5-nitro-2-pyridyldithio) pentanoate (SSNPP)
[229]
Anti-FGFR2 mAb-12433 Sulfo-SPDB-DM4
Anti-FGFR2 mAb 12433
FGFR2
Mertansine DM4
Sulfo-SPDB
[229]
Anti-FGFR2 mAb-12931 CX1-1-DM1
Anti-FGFR2 mAb 12931
FGFR2
Mertansine DM1
2,5-Dioxopyrrolidin-1-yl 17-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)-5,8,11,14-tetraazaheptadecan-1-oate (CX1-1)
[229]
Anti-FGFR2 mAb-12931 SMCC-DM1
Anti-FGFR2 mAb 12931
FGFR2
Mertansine DM1
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
[229]
Anti-FGFR2 mAb-12931 SPDB-DM4
Anti-FGFR2 mAb 12931
FGFR2
Mertansine DM4
N-succinimidyl 4-(2-pyridyldithio) butanoate (SPDB)
[229]
Anti-FGFR2 mAb-12931 SPDP-DM1
Anti-FGFR2 mAb 12931
FGFR2
Mertansine DM1
N-succinimidyl 3-(2-pyridyldithio) propionate (SPDP)
[229]
Anti-FGFR2 mAb-12931 SPP-DM1
Anti-FGFR2 mAb 12931
FGFR2
Mertansine DM1
N-succinimidyl 4-(2-pyridyldithio) pentanoate (SPP)
[229]
Anti-FGFR2 mAb-12931 SSNPP-DM3
Anti-FGFR2 mAb 12931
FGFR2
Maytansinoid DM3
Sulfosuccinimidyl-N-succinimidyl-4-(5-nitro-2-pyridyldithio) pentanoate (SSNPP)
[229]
Anti-FGFR2 mAb-12931 Sulfo-SPDB-DM4
Anti-FGFR2 mAb 12931
FGFR2
Mertansine DM4
Sulfo-SPDB
[229]
Anti-FGFR2 mAb-12944 CX1-1-DM1
Anti-FGFR2 mAb 12944
FGFR2
Mertansine DM1
2,5-Dioxopyrrolidin-1-yl 17-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)-5,8,11,14-tetraazaheptadecan-1-oate (CX1-1)
[229]
Anti-FGFR2 mAb-12944 SMCC-DM1
Anti-FGFR2 mAb 12944
FGFR2
Mertansine DM1
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
[229]
Anti-FGFR2 mAb-12944 SPDB-DM4
Anti-FGFR2 mAb 12944
FGFR2
Mertansine DM4
N-succinimidyl 4-(2-pyridyldithio) butanoate (SPDB)
[229]
Anti-FGFR2 mAb-12944 SPDP-DM1
Anti-FGFR2 mAb 12944
FGFR2
Mertansine DM1
N-succinimidyl 3-(2-pyridyldithio) propionate (SPDP)
[229]
Anti-FGFR2 mAb-12944 SPP-DM1
Anti-FGFR2 mAb 12944
FGFR2
Mertansine DM1
N-succinimidyl 4-(2-pyridyldithio) pentanoate (SPP)
[229]
Anti-FGFR2 mAb-12944 SSNPP-DM3
Anti-FGFR2 mAb 12944
FGFR2
Maytansinoid DM3
Sulfosuccinimidyl-N-succinimidyl-4-(5-nitro-2-pyridyldithio) pentanoate (SSNPP)
[229]
Anti-FGFR2 mAb-12944 Sulfo-SPDB-DM4
Anti-FGFR2 mAb 12944
FGFR2
Mertansine DM4
Sulfo-SPDB
[229]
Anti-FGFR2 mAb-12947 CX1-1-DM1
Anti-FGFR2 mAb 12947
FGFR2
Mertansine DM1
2,5-Dioxopyrrolidin-1-yl 17-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)-5,8,11,14-tetraazaheptadecan-1-oate (CX1-1)
[229]
Anti-FGFR2 mAb-12947 SMCC-DM1
Anti-FGFR2 mAb 12947
FGFR2
Mertansine DM1
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
[229]
Anti-FGFR2 mAb-12947 SPDB-DM4
Anti-FGFR2 mAb 12947
FGFR2
Mertansine DM4
N-succinimidyl 4-(2-pyridyldithio) butanoate (SPDB)
[229]
Anti-FGFR2 mAb-12947 SPDP-DM1
Anti-FGFR2 mAb 12947
FGFR2
Mertansine DM1
N-succinimidyl 3-(2-pyridyldithio) propionate (SPDP)
[229]
Anti-FGFR2 mAb-12947 SPP-DM1
Anti-FGFR2 mAb 12947
FGFR2
Mertansine DM1
N-succinimidyl 4-(2-pyridyldithio) pentanoate (SPP)
[229]
Anti-FGFR2 mAb-12947 SSNPP-DM3
Anti-FGFR2 mAb 12947
FGFR2
Maytansinoid DM3
Sulfosuccinimidyl-N-succinimidyl-4-(5-nitro-2-pyridyldithio) pentanoate (SSNPP)
[229]
Anti-FGFR2 mAb-12947 Sulfo-SPDB-DM4
Anti-FGFR2 mAb 12947
FGFR2
Mertansine DM4
Sulfo-SPDB
[229]
Anti-FGFR2/4 mAb-10553 CX1-1-DM1
Anti-FGFR2/4 mAb 10553
FGFR2; FGFR4
Mertansine DM1
2,5-Dioxopyrrolidin-1-yl 17-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)-5,8,11,14-tetraazaheptadecan-1-oate (CX1-1)
[229]
Anti-FGFR2/4 mAb-10553 SMCC-DM1
Anti-FGFR2/4 mAb 10553
FGFR2; FGFR4
Mertansine DM1
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
[229]
Anti-FGFR2/4 mAb-10553 SPDB-DM4
Anti-FGFR2/4 mAb 10553
FGFR2; FGFR4
Mertansine DM4
N-succinimidyl 4-(2-pyridyldithio) butanoate (SPDB)
[229]
Anti-FGFR2/4 mAb-10553 SPDP-DM1
Anti-FGFR2/4 mAb 10553
FGFR2; FGFR4
Mertansine DM1
N-succinimidyl 3-(2-pyridyldithio) propionate (SPDP)
[229]
Anti-FGFR2/4 mAb-10553 SPP-DM1
Anti-FGFR2/4 mAb 10553
FGFR2; FGFR4
Mertansine DM1
N-succinimidyl 4-(2-pyridyldithio) pentanoate (SPP)
[229]
Anti-FGFR2/4 mAb-10553 SSNPP-DM3
Anti-FGFR2/4 mAb 10553
FGFR2; FGFR4
Maytansinoid DM3
Sulfosuccinimidyl-N-succinimidyl-4-(5-nitro-2-pyridyldithio) pentanoate (SSNPP)
[229]
Anti-FGFR2/4 mAb-10553 Sulfo-SPDB-DM4
Anti-FGFR2/4 mAb 10553
FGFR2; FGFR4
Mertansine DM4
Sulfo-SPDB
[229]
Anti-FGFR2/4 mAb-10554 CX1-1-DM1
Anti-FGFR2/4 mAb 10554
FGFR2; FGFR4
Mertansine DM1
2,5-Dioxopyrrolidin-1-yl 17-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)-5,8,11,14-tetraazaheptadecan-1-oate (CX1-1)
[229]
Anti-FGFR2/4 mAb-10554 SMCC-DM1
Anti-FGFR2/4 mAb 10554
FGFR2; FGFR4
Mertansine DM1
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
[229]
Anti-FGFR2/4 mAb-10554 SPDB-DM4
Anti-FGFR2/4 mAb 10554
FGFR2; FGFR4
Mertansine DM4
N-succinimidyl 4-(2-pyridyldithio) butanoate (SPDB)
[229]
Anti-FGFR2/4 mAb-10554 SPDP-DM1
Anti-FGFR2/4 mAb 10554
FGFR2; FGFR4
Mertansine DM1
N-succinimidyl 3-(2-pyridyldithio) propionate (SPDP)
[229]
Anti-FGFR2/4 mAb-10554 SPP-DM1
Anti-FGFR2/4 mAb 10554
FGFR2; FGFR4
Mertansine DM1
N-succinimidyl 4-(2-pyridyldithio) pentanoate (SPP)
[229]
Anti-FGFR2/4 mAb-10554 SSNPP-DM3
Anti-FGFR2/4 mAb 10554
FGFR2; FGFR4
Maytansinoid DM3
Sulfosuccinimidyl-N-succinimidyl-4-(5-nitro-2-pyridyldithio) pentanoate (SSNPP)
[229]
Anti-FGFR2/4 mAb-10554 Sulfo-SPDB-DM4
Anti-FGFR2/4 mAb 10554
FGFR2; FGFR4
Mertansine DM4
Sulfo-SPDB
[229]
Anti-FGFR2/4 mAb-10729 CX1-1-DM1
Anti-FGFR2/4 mAb 10729
FGFR2; FGFR4
Mertansine DM1
2,5-Dioxopyrrolidin-1-yl 17-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)-5,8,11,14-tetraazaheptadecan-1-oate (CX1-1)
[229]
Anti-FGFR2/4 mAb-10729 SMCC-DM1
Anti-FGFR2/4 mAb 10729
FGFR2; FGFR4
Mertansine DM1
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
[229]
Anti-FGFR2/4 mAb-10729 SPDB-DM4
Anti-FGFR2/4 mAb 10729
FGFR2; FGFR4
Mertansine DM4
N-succinimidyl 4-(2-pyridyldithio) butanoate (SPDB)
[229]
Anti-FGFR2/4 mAb-10729 SPDP-DM1
Anti-FGFR2/4 mAb 10729
FGFR2; FGFR4
Mertansine DM1
N-succinimidyl 3-(2-pyridyldithio) propionate (SPDP)
[229]
Anti-FGFR2/4 mAb-10729 SPP-DM1
Anti-FGFR2/4 mAb 10729
FGFR2; FGFR4
Mertansine DM1
N-succinimidyl 4-(2-pyridyldithio) pentanoate (SPP)
[229]
Anti-FGFR2/4 mAb-10729 SSNPP-DM3
Anti-FGFR2/4 mAb 10729
FGFR2; FGFR4
Maytansinoid DM3
Sulfosuccinimidyl-N-succinimidyl-4-(5-nitro-2-pyridyldithio) pentanoate (SSNPP)
[229]
Anti-FGFR2/4 mAb-10729 Sulfo-SPDB-DM4
Anti-FGFR2/4 mAb 10729
FGFR2; FGFR4
Mertansine DM4
Sulfo-SPDB
[229]
Anti-FGFR2/4 mAb-10918 CX1-1-DM1
Anti-FGFR2/4 mAb 10918
FGFR2; FGFR4
Mertansine DM1
2,5-Dioxopyrrolidin-1-yl 17-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)-5,8,11,14-tetraazaheptadecan-1-oate (CX1-1)
[229]
Anti-FGFR2/4 mAb-10918 SMCC-DM1
Anti-FGFR2/4 mAb 10918
FGFR2; FGFR4
Mertansine DM1
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
[229]
Anti-FGFR2/4 mAb-10918 SPDB-DM4
Anti-FGFR2/4 mAb 10918
FGFR2; FGFR4
Mertansine DM4
N-succinimidyl 4-(2-pyridyldithio) butanoate (SPDB)
[229]
Anti-FGFR2/4 mAb-10918 SPDP-DM1
Anti-FGFR2/4 mAb 10918
FGFR2; FGFR4
Mertansine DM1
N-succinimidyl 3-(2-pyridyldithio) propionate (SPDP)
[229]
Anti-FGFR2/4 mAb-10918 SPP-DM1
Anti-FGFR2/4 mAb 10918
FGFR2; FGFR4
Mertansine DM1
N-succinimidyl 4-(2-pyridyldithio) pentanoate (SPP)
[229]
Anti-FGFR2/4 mAb-10918 SSNPP-DM3
Anti-FGFR2/4 mAb 10918
FGFR2; FGFR4
Maytansinoid DM3
Sulfosuccinimidyl-N-succinimidyl-4-(5-nitro-2-pyridyldithio) pentanoate (SSNPP)
[229]
Anti-FGFR2/4 mAb-10918 Sulfo-SPDB-DM4
Anti-FGFR2/4 mAb 10918
FGFR2; FGFR4
Mertansine DM4
Sulfo-SPDB
[229]
Anti-FGFR2/4 mAb-10923 CX1-1-DM1
Anti-FGFR2/4 mAb 10923
FGFR2; FGFR4
Mertansine DM1
2,5-Dioxopyrrolidin-1-yl 17-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)-5,8,11,14-tetraazaheptadecan-1-oate (CX1-1)
[229]
Anti-FGFR2/4 mAb-10923 SMCC-DM1
Anti-FGFR2/4 mAb 10923
FGFR2; FGFR4
Mertansine DM1
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
[229]
Anti-FGFR2/4 mAb-10923 SPDB-DM4
Anti-FGFR2/4 mAb 10923
FGFR2; FGFR4
Mertansine DM4
N-succinimidyl 4-(2-pyridyldithio) butanoate (SPDB)
[229]
Anti-FGFR2/4 mAb-10923 SPDP-DM1
Anti-FGFR2/4 mAb 10923
FGFR2; FGFR4
Mertansine DM1
N-succinimidyl 3-(2-pyridyldithio) propionate (SPDP)
[229]
Anti-FGFR2/4 mAb-10923 SPP-DM1
Anti-FGFR2/4 mAb 10923
FGFR2; FGFR4
Mertansine DM1
N-succinimidyl 4-(2-pyridyldithio) pentanoate (SPP)
[229]
Anti-FGFR2/4 mAb-10923 SSNPP-DM3
Anti-FGFR2/4 mAb 10923
FGFR2; FGFR4
Maytansinoid DM3
Sulfosuccinimidyl-N-succinimidyl-4-(5-nitro-2-pyridyldithio) pentanoate (SSNPP)
[229]
Anti-FGFR2/4 mAb-10923 Sulfo-SPDB-DM4
Anti-FGFR2/4 mAb 10923
FGFR2; FGFR4
Mertansine DM4
Sulfo-SPDB
[229]
Anti-FGFR2/4 mAb-10925 CX1-1-DM1
Anti-FGFR2/4 mAb 10925
FGFR2; FGFR4
Mertansine DM1
2,5-Dioxopyrrolidin-1-yl 17-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)-5,8,11,14-tetraazaheptadecan-1-oate (CX1-1)
[229]
Anti-FGFR2/4 mAb-10925 SMCC-DM1
Anti-FGFR2/4 mAb 10925
FGFR2; FGFR4
Mertansine DM1
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
[229]
Anti-FGFR2/4 mAb-10925 SPDB-DM4
Anti-FGFR2/4 mAb 10925
FGFR2; FGFR4
Mertansine DM4
N-succinimidyl 4-(2-pyridyldithio) butanoate (SPDB)
[229]
Anti-FGFR2/4 mAb-10925 SPDP-DM1
Anti-FGFR2/4 mAb 10925
FGFR2; FGFR4
Mertansine DM1
N-succinimidyl 3-(2-pyridyldithio) propionate (SPDP)
[229]
Anti-FGFR2/4 mAb-10925 SPP-DM1
Anti-FGFR2/4 mAb 10925
FGFR2; FGFR4
Mertansine DM1
N-succinimidyl 4-(2-pyridyldithio) pentanoate (SPP)
[229]
Anti-FGFR2/4 mAb-10925 SSNPP-DM3
Anti-FGFR2/4 mAb 10925
FGFR2; FGFR4
Maytansinoid DM3
Sulfosuccinimidyl-N-succinimidyl-4-(5-nitro-2-pyridyldithio) pentanoate (SSNPP)
[229]
Anti-FGFR2/4 mAb-10925 Sulfo-SPDB-DM4
Anti-FGFR2/4 mAb 10925
FGFR2; FGFR4
Mertansine DM4
Sulfo-SPDB
[229]
Anti-FGFR2/4 mAb-11722 CX1-1-DM1
Anti-FGFR2/4 mAb 11722
FGFR2; FGFR4
Mertansine DM1
2,5-Dioxopyrrolidin-1-yl 17-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)-5,8,11,14-tetraazaheptadecan-1-oate (CX1-1)
[229]
Anti-FGFR2/4 mAb-11722 SMCC-DM1
Anti-FGFR2/4 mAb 11722
FGFR2; FGFR4
Mertansine DM1
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
[229]
Anti-FGFR2/4 mAb-11722 SPDB-DM4
Anti-FGFR2/4 mAb 11722
FGFR2; FGFR4
Mertansine DM4
N-succinimidyl 4-(2-pyridyldithio) butanoate (SPDB)
[229]
Anti-FGFR2/4 mAb-11722 SPDP-DM1
Anti-FGFR2/4 mAb 11722
FGFR2; FGFR4
Mertansine DM1
N-succinimidyl 3-(2-pyridyldithio) propionate (SPDP)
[229]
Anti-FGFR2/4 mAb-11722 SPP-DM1
Anti-FGFR2/4 mAb 11722
FGFR2; FGFR4
Mertansine DM1
N-succinimidyl 4-(2-pyridyldithio) pentanoate (SPP)
[229]
Anti-FGFR2/4 mAb-11722 SSNPP-DM3
Anti-FGFR2/4 mAb 11722
FGFR2; FGFR4
Maytansinoid DM3
Sulfosuccinimidyl-N-succinimidyl-4-(5-nitro-2-pyridyldithio) pentanoate (SSNPP)
[229]
Anti-FGFR2/4 mAb-11722 Sulfo-SPDB-DM4
Anti-FGFR2/4 mAb 11722
FGFR2; FGFR4
Mertansine DM4
Sulfo-SPDB
[229]
Anti-FGFR2/4 mAb-12422 CX1-1-DM1
Anti-FGFR2/4 mAb 12422
FGFR2; FGFR4
Mertansine DM1
2,5-Dioxopyrrolidin-1-yl 17-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)-5,8,11,14-tetraazaheptadecan-1-oate (CX1-1)
[229]
Anti-FGFR2/4 mAb-12422 SMCC-DM1
Anti-FGFR2/4 mAb 12422
FGFR2; FGFR4
Mertansine DM1
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
[229]
Anti-FGFR2/4 mAb-12422 SPDB-DM4
Anti-FGFR2/4 mAb 12422
FGFR2; FGFR4
Mertansine DM4
N-succinimidyl 4-(2-pyridyldithio) butanoate (SPDB)
[229]
Anti-FGFR2/4 mAb-12422 SPDP-DM1
Anti-FGFR2/4 mAb 12422
FGFR2; FGFR4
Mertansine DM1
N-succinimidyl 3-(2-pyridyldithio) propionate (SPDP)
[229]
Anti-FGFR2/4 mAb-12422 SPP-DM1
Anti-FGFR2/4 mAb 12422
FGFR2; FGFR4
Mertansine DM1
N-succinimidyl 4-(2-pyridyldithio) pentanoate (SPP)
[229]
Anti-FGFR2/4 mAb-12422 SSNPP-DM3
Anti-FGFR2/4 mAb 12422
FGFR2; FGFR4
Maytansinoid DM3
Sulfosuccinimidyl-N-succinimidyl-4-(5-nitro-2-pyridyldithio) pentanoate (SSNPP)
[229]
Anti-FGFR2/4 mAb-12422 Sulfo-SPDB-DM4
Anti-FGFR2/4 mAb 12422
FGFR2; FGFR4
Mertansine DM4
Sulfo-SPDB
[229]
Anti-FGFR2/4 mAb-12425 CX1-1-DM1
Anti-FGFR2/4 mAb 12425
FGFR2; FGFR4
Mertansine DM1
2,5-Dioxopyrrolidin-1-yl 17-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)-5,8,11,14-tetraazaheptadecan-1-oate (CX1-1)
[229]
Anti-FGFR2/4 mAb-12425 SMCC-DM1
Anti-FGFR2/4 mAb 12425
FGFR2; FGFR4
Mertansine DM1
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
[229]
Anti-FGFR2/4 mAb-12425 SPDB-DM4
Anti-FGFR2/4 mAb 12425
FGFR2; FGFR4
Mertansine DM4
N-succinimidyl 4-(2-pyridyldithio) butanoate (SPDB)
[229]
Anti-FGFR2/4 mAb-12425 SPDP-DM1
Anti-FGFR2/4 mAb 12425
FGFR2; FGFR4
Mertansine DM1
N-succinimidyl 3-(2-pyridyldithio) propionate (SPDP)
[229]
Anti-FGFR2/4 mAb-12425 SPP-DM1
Anti-FGFR2/4 mAb 12425
FGFR2; FGFR4
Mertansine DM1
N-succinimidyl 4-(2-pyridyldithio) pentanoate (SPP)
[229]
Anti-FGFR2/4 mAb-12425 SSNPP-DM3
Anti-FGFR2/4 mAb 12425
FGFR2; FGFR4
Maytansinoid DM3
Sulfosuccinimidyl-N-succinimidyl-4-(5-nitro-2-pyridyldithio) pentanoate (SSNPP)
[229]
Anti-FGFR2/4 mAb-12425 Sulfo-SPDB-DM4
Anti-FGFR2/4 mAb 12425
FGFR2; FGFR4
Mertansine DM4
Sulfo-SPDB
[229]
Anti-FGFR2/4 mAb-12435 CX1-1-DM1
Anti-FGFR2/4 mAb 12435
FGFR2; FGFR4
Mertansine DM1
2,5-Dioxopyrrolidin-1-yl 17-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)-5,8,11,14-tetraazaheptadecan-1-oate (CX1-1)
[229]
Anti-FGFR2/4 mAb-12435 SMCC-DM1
Anti-FGFR2/4 mAb 12435
FGFR2; FGFR4
Mertansine DM1
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
[229]
Anti-FGFR2/4 mAb-12435 SPDB-DM4
Anti-FGFR2/4 mAb 12435
FGFR2; FGFR4
Mertansine DM4
N-succinimidyl 4-(2-pyridyldithio) butanoate (SPDB)
[229]
Anti-FGFR2/4 mAb-12435 SPDP-DM1
Anti-FGFR2/4 mAb 12435
FGFR2; FGFR4
Mertansine DM1
N-succinimidyl 3-(2-pyridyldithio) propionate (SPDP)
[229]
Anti-FGFR2/4 mAb-12435 SPP-DM1
Anti-FGFR2/4 mAb 12435
FGFR2; FGFR4
Mertansine DM1
N-succinimidyl 4-(2-pyridyldithio) pentanoate (SPP)
[229]
Anti-FGFR2/4 mAb-12435 SSNPP-DM3
Anti-FGFR2/4 mAb 12435
FGFR2; FGFR4
Maytansinoid DM3
Sulfosuccinimidyl-N-succinimidyl-4-(5-nitro-2-pyridyldithio) pentanoate (SSNPP)
[229]
Anti-FGFR2/4 mAb-12435 Sulfo-SPDB-DM4
Anti-FGFR2/4 mAb 12435
FGFR2; FGFR4
Mertansine DM4
Sulfo-SPDB
[229]
Anti-FGFR2/4 mAb-12438 CX1-1-DM1
Anti-FGFR2/4 mAb 12438
FGFR2; FGFR4
Mertansine DM1
2,5-Dioxopyrrolidin-1-yl 17-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)-5,8,11,14-tetraazaheptadecan-1-oate (CX1-1)
[229]
Anti-FGFR2/4 mAb-12438 SMCC-DM1
Anti-FGFR2/4 mAb 12438
FGFR2; FGFR4
Mertansine DM1
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
[229]
Anti-FGFR2/4 mAb-12438 SPDB-DM4
Anti-FGFR2/4 mAb 12438
FGFR2; FGFR4
Mertansine DM4
N-succinimidyl 4-(2-pyridyldithio) butanoate (SPDB)
[229]
Anti-FGFR2/4 mAb-12438 SPDP-DM1
Anti-FGFR2/4 mAb 12438
FGFR2; FGFR4
Mertansine DM1
N-succinimidyl 3-(2-pyridyldithio) propionate (SPDP)
[229]
Anti-FGFR2/4 mAb-12438 SPP-DM1
Anti-FGFR2/4 mAb 12438
FGFR2; FGFR4
Mertansine DM1
N-succinimidyl 4-(2-pyridyldithio) pentanoate (SPP)
[229]
Anti-FGFR2/4 mAb-12438 SSNPP-DM3
Anti-FGFR2/4 mAb 12438
FGFR2; FGFR4
Maytansinoid DM3
Sulfosuccinimidyl-N-succinimidyl-4-(5-nitro-2-pyridyldithio) pentanoate (SSNPP)
[229]
Anti-FGFR2/4 mAb-12438 Sulfo-SPDB-DM4
Anti-FGFR2/4 mAb 12438
FGFR2; FGFR4
Mertansine DM4
Sulfo-SPDB
[229]
Anti-FGFR2/4 mAb-12439 CX1-1-DM1
Anti-FGFR2/4 mAb 12439
FGFR2; FGFR4
Mertansine DM1
2,5-Dioxopyrrolidin-1-yl 17-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)-5,8,11,14-tetraazaheptadecan-1-oate (CX1-1)
[229]
Anti-FGFR2/4 mAb-12439 SMCC-DM1
Anti-FGFR2/4 mAb 12439
FGFR2; FGFR4
Mertansine DM1
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
[229]
Anti-FGFR2/4 mAb-12439 SPDB-DM4
Anti-FGFR2/4 mAb 12439
FGFR2; FGFR4
Mertansine DM4
N-succinimidyl 4-(2-pyridyldithio) butanoate (SPDB)
[229]
Anti-FGFR2/4 mAb-12439 SPDP-DM1
Anti-FGFR2/4 mAb 12439
FGFR2; FGFR4
Mertansine DM1
N-succinimidyl 3-(2-pyridyldithio) propionate (SPDP)
[229]
Anti-FGFR2/4 mAb-12439 SPP-DM1
Anti-FGFR2/4 mAb 12439
FGFR2; FGFR4
Mertansine DM1
N-succinimidyl 4-(2-pyridyldithio) pentanoate (SPP)
[229]
Anti-FGFR2/4 mAb-12439 SSNPP-DM3
Anti-FGFR2/4 mAb 12439
FGFR2; FGFR4
Maytansinoid DM3
Sulfosuccinimidyl-N-succinimidyl-4-(5-nitro-2-pyridyldithio) pentanoate (SSNPP)
[229]
Anti-FGFR2/4 mAb-12439 Sulfo-SPDB-DM4
Anti-FGFR2/4 mAb 12439
FGFR2; FGFR4
Mertansine DM4
Sulfo-SPDB
[229]
Anti-FGFR2/4 mAb-14629 CX1-1-DM1
Anti-FGFR2/4 mAb 14629
FGFR2; FGFR4
Mertansine DM1
2,5-Dioxopyrrolidin-1-yl 17-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)-5,8,11,14-tetraazaheptadecan-1-oate (CX1-1)
[229]
Anti-FGFR2/4 mAb-14629 SMCC-DM1
Anti-FGFR2/4 mAb 14629
FGFR2; FGFR4
Mertansine DM1
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
[229]
Anti-FGFR2/4 mAb-14629 SPDB-DM4
Anti-FGFR2/4 mAb 14629
FGFR2; FGFR4
Mertansine DM4
N-succinimidyl 4-(2-pyridyldithio) butanoate (SPDB)
[229]
Anti-FGFR2/4 mAb-14629 SPDP-DM1
Anti-FGFR2/4 mAb 14629
FGFR2; FGFR4
Mertansine DM1
N-succinimidyl 3-(2-pyridyldithio) propionate (SPDP)
[229]
Anti-FGFR2/4 mAb-14629 SPP-DM1
Anti-FGFR2/4 mAb 14629
FGFR2; FGFR4
Mertansine DM1
N-succinimidyl 4-(2-pyridyldithio) pentanoate (SPP)
[229]
Anti-FGFR2/4 mAb-14629 SSNPP-DM3
Anti-FGFR2/4 mAb 14629
FGFR2; FGFR4
Maytansinoid DM3
Sulfosuccinimidyl-N-succinimidyl-4-(5-nitro-2-pyridyldithio) pentanoate (SSNPP)
[229]
Anti-FGFR2/4 mAb-14629 Sulfo-SPDB-DM4
Anti-FGFR2/4 mAb 14629
FGFR2; FGFR4
Mertansine DM4
Sulfo-SPDB
[229]
Anti-FGFR2/4 mAb-20562 CX1-1-DM1
Anti-FGFR2/4 mAb 20562
FGFR2; FGFR4
Mertansine DM1
2,5-Dioxopyrrolidin-1-yl 17-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)-5,8,11,14-tetraazaheptadecan-1-oate (CX1-1)
[229]
Anti-FGFR2/4 mAb-20562 SMCC-DM1
Anti-FGFR2/4 mAb 20562
FGFR2; FGFR4
Mertansine DM1
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
[229]
Anti-FGFR2/4 mAb-20562 SPDB-DM4
Anti-FGFR2/4 mAb 20562
FGFR2; FGFR4
Mertansine DM4
N-succinimidyl 4-(2-pyridyldithio) butanoate (SPDB)
[229]
Anti-FGFR2/4 mAb-20562 SPDP-DM1
Anti-FGFR2/4 mAb 20562
FGFR2; FGFR4
Mertansine DM1
N-succinimidyl 3-(2-pyridyldithio) propionate (SPDP)
[229]
Anti-FGFR2/4 mAb-20562 SPP-DM1
Anti-FGFR2/4 mAb 20562
FGFR2; FGFR4
Mertansine DM1
N-succinimidyl 4-(2-pyridyldithio) pentanoate (SPP)
[229]
Anti-FGFR2/4 mAb-20562 SSNPP-DM3
Anti-FGFR2/4 mAb 20562
FGFR2; FGFR4
Maytansinoid DM3
Sulfosuccinimidyl-N-succinimidyl-4-(5-nitro-2-pyridyldithio) pentanoate (SSNPP)
[229]
Anti-FGFR2/4 mAb-20562 Sulfo-SPDB-DM4
Anti-FGFR2/4 mAb 20562
FGFR2; FGFR4
Mertansine DM4
Sulfo-SPDB
[229]
Anti-FGFR2/4 mAb-20811 CX1-1-DM1
Anti-FGFR2/4 mAb 20811
FGFR2; FGFR4
Mertansine DM1
2,5-Dioxopyrrolidin-1-yl 17-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)-5,8,11,14-tetraazaheptadecan-1-oate (CX1-1)
[229]
Anti-FGFR2/4 mAb-20811 SMCC-DM1
Anti-FGFR2/4 mAb 20811
FGFR2; FGFR4
Mertansine DM1
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
[229]
Anti-FGFR2/4 mAb-20811 SPDB-DM4
Anti-FGFR2/4 mAb 20811
FGFR2; FGFR4
Mertansine DM4
N-succinimidyl 4-(2-pyridyldithio) butanoate (SPDB)
[229]
Anti-FGFR2/4 mAb-20811 SPDP-DM1
Anti-FGFR2/4 mAb 20811
FGFR2; FGFR4
Mertansine DM1
N-succinimidyl 3-(2-pyridyldithio) propionate (SPDP)
[229]
Anti-FGFR2/4 mAb-20811 SPP-DM1
Anti-FGFR2/4 mAb 20811
FGFR2; FGFR4
Mertansine DM1
N-succinimidyl 4-(2-pyridyldithio) pentanoate (SPP)
[229]
Anti-FGFR2/4 mAb-20811 SSNPP-DM3
Anti-FGFR2/4 mAb 20811
FGFR2; FGFR4
Maytansinoid DM3
Sulfosuccinimidyl-N-succinimidyl-4-(5-nitro-2-pyridyldithio) pentanoate (SSNPP)
[229]
Anti-FGFR2/4 mAb-20811 Sulfo-SPDB-DM4
Anti-FGFR2/4 mAb 20811
FGFR2; FGFR4
Mertansine DM4
Sulfo-SPDB
[229]
Anti-HER2 antibody-drug conjugate (Spirea)
Trastuzumab
ERBB2
Monomethyl auristatin E
Undisclosed
[230]
Anti-HER2 DVD-Fab_MMAF
Anti-HER2 DVD-Fab
ERBB2
Monomethyl auristatin F
Dibromomaleimide-PEG4
[231]
Anti-HER2 DVD-Fab-h38c2-K99C_MMAF
Anti-HER2 DVD-Fab-h38c2-K99C
ERBB2
Monomethyl auristatin F
Dibromomaleimide-PEG4
[231]
Anti-HER2 DVD-IgG1_MMAF
Anti-HER2 DVD-IgG1
ERBB2
Monomethyl auristatin F
Dibromomaleimide-PEG4
[231]
Anti-HER2 DVD-IgG1-h38c2-K99C_MMAF
Anti-HER2 DVD-IgG1-H38c2-K99C
ERBB2
Monomethyl auristatin F
Dibromomaleimide-PEG4
[231]
Anti-HER2 DVD-IgG1-Tiancimycin
Anti-HER2 DVD-IgG1
ERBB2
Tiancimycin
DVD-PEG4-Triazol
[232]
Anti-HER2 mAb-Compound 17
Anti-HER2 mAb
ERBB2
Mertansine DM4
Anti-HER2 mAb-Compound 17 linker
[200]
Anti-HER2 mAb-Compound 25
Anti-HER2 mAb
ERBB2
Monomethyl auristatin E
Anti-HER2 mAb-Compound 25 linker
[200]
Anti-HER2 mAb-Compound 31
Anti-HER2 mAb
ERBB2
Auristatin 0101
Anti-HER2 mAb-Compound 31 linker
[200]
Anti-HER2 mAb-Compound 36
Anti-HER2 mAb
ERBB2
Monomethyl auristatin E
Anti-HER2 mAb-Compound 36 linker
[200]
Anti-HER2 mAb-Compound 55
Anti-HER2 mAb
ERBB2
Mertansine DM1
Anti-HER2 mAb-Compound 55 linker
[200]
Anti-HER2 mAb-Compound 59
Anti-HER2 mAb
ERBB2
Mertansine DM4
Anti-HER2 mAb-Compound 59 linker
[200]
Anti-HER2 mAb-Compound 64
Anti-HER2 mAb
ERBB2
Monomethyl auristatin E
Anti-HER2 mAb-Compound 64 linker
[200]
Anti-HER2 mAb-Compound 69
Anti-HER2 mAb
ERBB2
Monomethyl auristatin E
Anti-HER2 mAb-Compound 69 linker
[200]
Anti-HER2 mAb-Compound 75
Anti-HER2 mAb
ERBB2
Monomethyl auristatin E
Anti-HER2 mAb-Compound 75 linker
[200]
Anti-HER2 mAb-Compound 76
Anti-HER2 mAb
ERBB2
Monomethyl auristatin E
Anti-HER2 mAb-Compound 76 linker
[200]
Anti-HER2 mAb-Compound 77
Anti-HER2 mAb
ERBB2
Mertansine DM1
Anti-HER2 mAb-Compound 77 linker
[200]
Anti-HER2 mAb-Compound 78
Anti-HER2 mAb
ERBB2
Auristatin 0101
Anti-HER2 mAb-Compound 78 linker
[200]
Anti-HER2 mAb-Compound 79
Anti-HER2 mAb
ERBB2
Auristatin 0101
Anti-HER2 mAb-Compound 79 linker
[200]
Anti-HER2 mAb-Compound 80
Anti-HER2 mAb
ERBB2
Mertansine DM4
Anti-HER2 mAb-Compound 80 linker
[200]
Anti-HER2 mAb-Compound 9
Anti-HER2 mAb
ERBB2
Mertansine DM1
Anti-HER2 mAb-Compound 9 linker
[200]
Anti-HER2 scFv-Fc (Ser396Sec)-CN29
Anti-HER2 scFv-Fc (Ser396Sec)
ERBB2
Monomethyl auristatin F derivative peptide (CN29)
Lodoacetamido-caproyl
[233]
Anti-HER-AO-Cys-MC-VC-PABC-MMAE
Anti-HER2 mAb WT
ERBB2
Monomethyl auristatin E
Anti-HER-AO-Cys-MC-VC-PABC-MMAE linker
[177]
Anti-ICOS-MMAE
Murine Anti-ICOS Anti-ody
ICOS
Monomethyl auristatin E
Undisclosed
[234]
Anti-IL13RA2-ADC
Anti-IL13RA2 PF-06473811 mAb
IL13RA2
Auristatin 0101
Mc-Val-Cit-PABC
[235]
Anti-KIT 20376 Sulfo-SPDB-DM4
Anti-KIT mAb 20376
KIT
Mertansine DM4
Sulfo-SPDB
[236]
Anti-KIT 20376?CX1-1-DM1
Anti-KIT mAb 20376
KIT
Mertansine DM1
2,5-Dioxopyrrolidin-1-yl 17-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)-5,8,11,14-tetraazaheptadecan-1-oate (CX1-1)
[236]
Anti-KIT 20376?SMCC-DM1
Anti-KIT mAb 20376
KIT
Mertansine DM1
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
[236]
Anti-KIT 20376?SPDB-DM4
Anti-KIT mAb 20376
KIT
Mertansine DM4
N-succinimidyl 4-(2-pyridyldithio) butanoate (SPDB)
[236]
Anti-KIT 20376?SPDP-DM1
Anti-KIT mAb 20376
KIT
Mertansine DM1
N-succinimidyl 3-(2-pyridyldithio) propionate (SPDP)
[236]
Anti-KIT 20376?SPP-DM1
Anti-KIT mAb 20376
KIT
Mertansine DM1
N-succinimidyl 4-(2-pyridyldithio) pentanoate (SPP)
[236]
Anti-KIT 20376?SSNPP-DM3
Anti-KIT mAb 20376
KIT
Maytansinoid DM3
Sulfosuccinimidyl-N-succinimidyl-4-(5-nitro-2-pyridyldithio) pentanoate (SSNPP)
[236]
Anti-KIT 9P3 Sulfo-SPDB-DM4
Anti-KIT mAb 9P3
KIT
Mertansine DM4
Sulfo-SPDB
[236]
Anti-KIT 9P3?CX1-1-DM1
Anti-KIT mAb 9P3
KIT
Mertansine DM1
2,5-Dioxopyrrolidin-1-yl 17-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)-5,8,11,14-tetraazaheptadecan-1-oate (CX1-1)
[236]
Anti-KIT 9P3?SMCC-DM1
Anti-KIT mAb 9P3
KIT
Mertansine DM1
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
[236]
Anti-KIT 9P3?SPDB-DM4
Anti-KIT mAb 9P3
KIT
Mertansine DM4
N-succinimidyl 4-(2-pyridyldithio) butanoate (SPDB)
[236]
Anti-KIT 9P3?SPDP-DM1
Anti-KIT mAb 9P3
KIT
Mertansine DM1
N-succinimidyl 3-(2-pyridyldithio) propionate (SPDP)
[236]
Anti-KIT 9P3?SPP-DM1
Anti-KIT mAb 9P3
KIT
Mertansine DM1
N-succinimidyl 4-(2-pyridyldithio) pentanoate (SPP)
[236]
Anti-KIT 9P3?SSNPP-DM3
Anti-KIT mAb 9P3
KIT
Maytansinoid DM3
Sulfosuccinimidyl-N-succinimidyl-4-(5-nitro-2-pyridyldithio) pentanoate (SSNPP)
[236]
Anti-KIT NEG024 Sulfo-SPDB-DM4
Anti-KIT mAb NEG024
KIT
Mertansine DM4
Sulfo-SPDB
[236]
Anti-KIT NEG024?CX1-1-DM1
Anti-KIT mAb NEG024
KIT
Mertansine DM1
2,5-Dioxopyrrolidin-1-yl 17-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)-5,8,11,14-tetraazaheptadecan-1-oate (CX1-1)
[236]
Anti-KIT NEG024?SMCC-DM1
Anti-KIT mAb NEG024
KIT
Mertansine DM1
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
[236]
Anti-KIT NEG024?SPDB-DM4
Anti-KIT mAb NEG024
KIT
Mertansine DM4
N-succinimidyl 4-(2-pyridyldithio) butanoate (SPDB)
[236]
Anti-KIT NEG024?SPDP-DM1
Anti-KIT mAb NEG024
KIT
Mertansine DM1
N-succinimidyl 3-(2-pyridyldithio) propionate (SPDP)
[236]
Anti-KIT NEG024?SPP-DM1
Anti-KIT mAb NEG024
KIT
Mertansine DM1
N-succinimidyl 4-(2-pyridyldithio) pentanoate (SPP)
[236]
Anti-KIT NEG024?SSNPP-DM3
Anti-KIT mAb NEG024
KIT
Maytansinoid DM3
Sulfosuccinimidyl-N-succinimidyl-4-(5-nitro-2-pyridyldithio) pentanoate (SSNPP)
[236]
Anti-KIT NEG026 Sulfo-SPDB-DM4
Anti-KIT mAb NEG026
KIT
Mertansine DM4
Sulfo-SPDB
[236]
Anti-KIT NEG026?CX1-1-DM1
Anti-KIT mAb NEG026
KIT
Mertansine DM1
2,5-Dioxopyrrolidin-1-yl 17-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)-5,8,11,14-tetraazaheptadecan-1-oate (CX1-1)
[236]
Anti-KIT NEG026?SMCC-DM1
Anti-KIT mAb NEG026
KIT
Mertansine DM1
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
[236]
Anti-KIT NEG026?SPDB-DM4
Anti-KIT mAb NEG026
KIT
Mertansine DM4
N-succinimidyl 4-(2-pyridyldithio) butanoate (SPDB)
[236]
Anti-KIT NEG026?SPDP-DM1
Anti-KIT mAb NEG026
KIT
Mertansine DM1
N-succinimidyl 3-(2-pyridyldithio) propionate (SPDP)
[236]
Anti-KIT NEG026?SPP-DM1
Anti-KIT mAb NEG026
KIT
Mertansine DM1
N-succinimidyl 4-(2-pyridyldithio) pentanoate (SPP)
[236]
Anti-KIT NEG026?SSNPP-DM3
Anti-KIT mAb NEG026
KIT
Maytansinoid DM3
Sulfosuccinimidyl-N-succinimidyl-4-(5-nitro-2-pyridyldithio) pentanoate (SSNPP)
[236]
Anti-KIT NEG027 Sulfo-SPDB-DM4
Anti-KIT mAb NEG027
KIT
Mertansine DM4
Sulfo-SPDB
[236]
Anti-KIT NEG027?CX1-1-DM1
Anti-KIT mAb NEG027
KIT
Mertansine DM1
2,5-Dioxopyrrolidin-1-yl 17-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)-5,8,11,14-tetraazaheptadecan-1-oate (CX1-1)
[236]
Anti-KIT NEG027?SMCC-DM1
Anti-KIT mAb NEG027
KIT
Mertansine DM1
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
[236]
Anti-KIT NEG027?SPDB-DM4
Anti-KIT mAb NEG027
KIT
Mertansine DM4
N-succinimidyl 4-(2-pyridyldithio) butanoate (SPDB)
[236]
Anti-KIT NEG027?SPDP-DM1
Anti-KIT mAb NEG027
KIT
Mertansine DM1
N-succinimidyl 3-(2-pyridyldithio) propionate (SPDP)
[236]
Anti-KIT NEG027?SPP-DM1
Anti-KIT mAb NEG027
KIT
Mertansine DM1
N-succinimidyl 4-(2-pyridyldithio) pentanoate (SPP)
[236]
Anti-KIT NEG027?SSNPP-DM3
Anti-KIT mAb NEG027
KIT
Maytansinoid DM3
Sulfosuccinimidyl-N-succinimidyl-4-(5-nitro-2-pyridyldithio) pentanoate (SSNPP)
[236]
Anti-KIT NEG085 Sulfo-SPDB-DM4
Anti-KIT mAb NEG085
KIT
Mertansine DM4
Sulfo-SPDB
[236]
Anti-KIT NEG085?CX1-1-DM1
Anti-KIT mAb NEG085
KIT
Mertansine DM1
2,5-Dioxopyrrolidin-1-yl 17-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)-5,8,11,14-tetraazaheptadecan-1-oate (CX1-1)
[236]
Anti-KIT NEG085?SMCC-DM1
Anti-KIT mAb NEG085
KIT
Mertansine DM1
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
[236]
Anti-KIT NEG085?SPDB-DM4
Anti-KIT mAb NEG085
KIT
Mertansine DM4
N-succinimidyl 4-(2-pyridyldithio) butanoate (SPDB)
[236]
Anti-KIT NEG085?SPDP-DM1
Anti-KIT mAb NEG085
KIT
Mertansine DM1
N-succinimidyl 3-(2-pyridyldithio) propionate (SPDP)
[236]
Anti-KIT NEG085?SPP-DM1
Anti-KIT mAb NEG085
KIT
Mertansine DM1
N-succinimidyl 4-(2-pyridyldithio) pentanoate (SPP)
[236]
Anti-KIT NEG085?SSNPP-DM3
Anti-KIT mAb NEG085
KIT
Maytansinoid DM3
Sulfosuccinimidyl-N-succinimidyl-4-(5-nitro-2-pyridyldithio) pentanoate (SSNPP)
[236]
Anti-KIT NEG086 Sulfo-SPDB-DM4
Anti-KIT mAb NEG086
KIT
Mertansine DM4
Sulfo-SPDB
[236]
Anti-KIT NEG086?CX1-1-DM1
Anti-KIT mAb NEG086
KIT
Mertansine DM1
2,5-Dioxopyrrolidin-1-yl 17-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)-5,8,11,14-tetraazaheptadecan-1-oate (CX1-1)
[236]
Anti-KIT NEG086?SMCC-DM1
Anti-KIT mAb NEG086
KIT
Mertansine DM1
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
[236]
Anti-KIT NEG086?SPDB-DM4
Anti-KIT mAb NEG086
KIT
Mertansine DM4
N-succinimidyl 4-(2-pyridyldithio) butanoate (SPDB)
[236]
Anti-KIT NEG086?SPDP-DM1
Anti-KIT mAb NEG086
KIT
Mertansine DM1
N-succinimidyl 3-(2-pyridyldithio) propionate (SPDP)
[236]
Anti-KIT NEG086?SPP-DM1
Anti-KIT mAb NEG086
KIT
Mertansine DM1
N-succinimidyl 4-(2-pyridyldithio) pentanoate (SPP)
[236]
Anti-KIT NEG086?SSNPP-DM3
Anti-KIT mAb NEG086
KIT
Maytansinoid DM3
Sulfosuccinimidyl-N-succinimidyl-4-(5-nitro-2-pyridyldithio) pentanoate (SSNPP)
[236]
Anti-KIT NEG087 Sulfo-SPDB-DM4
Anti-KIT mAb NEG087
KIT
Mertansine DM4
Sulfo-SPDB
[236]
Anti-KIT NEG087?CX1-1-DM1
Anti-KIT mAb NEG087
KIT
Mertansine DM1
2,5-Dioxopyrrolidin-1-yl 17-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)-5,8,11,14-tetraazaheptadecan-1-oate (CX1-1)
[236]
Anti-KIT NEG087?SMCC-DM1
Anti-KIT mAb NEG087
KIT
Mertansine DM1
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
[236]
Anti-KIT NEG087?SPDB-DM4
Anti-KIT mAb NEG087
KIT
Mertansine DM4
N-succinimidyl 4-(2-pyridyldithio) butanoate (SPDB)
[236]
Anti-KIT NEG087?SPDP-DM1
Anti-KIT mAb NEG087
KIT
Mertansine DM1
N-succinimidyl 3-(2-pyridyldithio) propionate (SPDP)
[236]
Anti-KIT NEG087?SPP-DM1
Anti-KIT mAb NEG087
KIT
Mertansine DM1
N-succinimidyl 4-(2-pyridyldithio) pentanoate (SPP)
[236]
Anti-KIT NEG087?SSNPP-DM3
Anti-KIT mAb NEG087
KIT
Maytansinoid DM3
Sulfosuccinimidyl-N-succinimidyl-4-(5-nitro-2-pyridyldithio) pentanoate (SSNPP)
[236]
Anti-MSL1 mAb-Compound 17
Anti-MSL1 mAb
MSL1
Mertansine DM4
Anti-MSL1 mAb-Compound 17 linker
[200]
Anti-MSL1 mAb-Compound 25
Anti-MSL1 mAb
MSL1
Monomethyl auristatin E
Anti-MSL1 mAb-Compound 25 linker
[200]
Anti-MSL1 mAb-Compound 31
Anti-MSL1 mAb
MSL1
Auristatin 0101
Anti-MSL1 mAb-Compound 31 linker
[200]
Anti-MSL1 mAb-Compound 36
Anti-MSL1 mAb
MSL1
Monomethyl auristatin E
Anti-MSL1 mAb-Compound 36 linker
[200]
Anti-MSL1 mAb-Compound 55
Anti-MSL1 mAb
MSL1
Mertansine DM1
Anti-MSL1 mAb-Compound 55 linker
[200]
Anti-MSL1 mAb-Compound 59
Anti-MSL1 mAb
MSL1
Mertansine DM4
Anti-MSL1 mAb-Compound 59 linker
[200]
Anti-MSL1 mAb-Compound 64
Anti-MSL1 mAb
MSL1
Monomethyl auristatin E
Anti-MSL1 mAb-Compound 64 linker
[200]
Anti-MSL1 mAb-Compound 69
Anti-MSL1 mAb
MSL1
Monomethyl auristatin E
Anti-MSL1 mAb-Compound 69 linker
[200]
Anti-MSL1 mAb-Compound 75
Anti-MSL1 mAb
MSL1
Monomethyl auristatin E
Anti-MSL1 mAb-Compound 75 linker
[200]
Anti-MSL1 mAb-Compound 76
Anti-MSL1 mAb
MSL1
Monomethyl auristatin E
Anti-MSL1 mAb-Compound 76 linker
[200]
Anti-MSL1 mAb-Compound 77
Anti-MSL1 mAb
MSL1
Mertansine DM1
Anti-MSL1 mAb-Compound 77 linker
[200]
Anti-MSL1 mAb-Compound 78
Anti-MSL1 mAb
MSL1
Auristatin 0101
Anti-MSL1 mAb-Compound 78 linker
[200]
Anti-MSL1 mAb-Compound 79
Anti-MSL1 mAb
MSL1
Auristatin 0101
Anti-MSL1 mAb-Compound 79 linker
[200]
Anti-MSL1 mAb-Compound 80
Anti-MSL1 mAb
MSL1
Mertansine DM4
Anti-MSL1 mAb-Compound 80 linker
[200]
Anti-MSL1 mAb-Compound 9
Anti-MSL1 mAb
MSL1
Mertansine DM1
Anti-MSL1 mAb-Compound 9 linker
[200]
Anti-MUC16 antibody 3A5-BMPEO-DM1
Anti-MUC16 antibody 3A5
MUC16
Maytansinoid DM1
Anti-MUC16 antibody 3A5-BMPEO-DM1 linker
[187]
Anti-N3(i)-vc0101
Anti-NOTCH3(i) mAb
NOTCH3
Auristatin 0101
Mc-Val-Cit-PABC
[237]
Anti-N3-vc0101
Anti-NOTCH3 mAb
NOTCH3
Auristatin 0101
Mc-Val-Cit-PABC
[237]
Anti-NaPi3b antibody-drug conjugate (Genentech/Roche)
Undisclosed
SLC34A2
Monomethyl auristatin E
Undisclosed
[238]
Anti-PIEZO1-MMAE
Anti-PIEZO1 mAb
PIEZO1
Monomethyl auristatin E
Mc-Val-Cit-PABC
[239]
Anti-SSTR2 ADC
Anti-human and mouse SSTR2 mAb (IgG1 kappa)
SSTR2
Mertansine DM1
Sulfo-SMCC
[240]
Anti-TrkB DVD-ADC
TrkB-DVD (h38C2)
NTRK2
Monomethyl auristatin F
Hexapeptide linker ASTKGP
[241]
Anti-TrkB mAb 641 ADC
Anti-TrkB mAb 641
NTRK2
Monomethyl auristatin F
Hexapeptide linker ASTKGP
[241]
APH-0912
Undisclosed
Undisclosed
Docetaxel
Hydrophilic linker containing sugar molecules
[242]
APLP2/HER2 antibody-drug conjugate
Undisclosed
APLP2; ERBB2
Mertansine DM1
Undisclosed
[243]
Araris ADC
Enfortumab
NECTIN4
Monomethyl auristatin E
Cathepsin B cleavable linker
[244]
ARC-02
Undisclosed
CD79B
Monomethyl auristatin E
Undisclosed
[245]
ASG-15MF
Sirtratumab
SLITRK6
Monomethyl auristatin F
Maleimido-caproyl
[246]
Atezolizumab ADC
Atezolizumab
CD274
Monomethyl auristatin E
Mc-Val-Cit-PABC
[247]
AVID-300
Panitumumab
EGFR
Mertansine DM1
Undisclosed
[248]
AVP10
Undisclosed
TNFRSF8
Monomethyl auristatin F
Undisclosed
[249]
AXL02
AXL Anti-ody YW327.6S2
AXL
Monomethyl auristatin E
Mc-Val-Cit-PABC
[250]
AXL02-MMAE
Anti-AXL mAb AXL02
AXL
Monomethyl auristatin E
Mc-Val-Cit-PABC
[251]
AXL-148-MMAE
AXL-148
AXL
Monomethyl auristatin E
Mc-Val-Cit-PABC
[252]
AXL-154-M103L-MMAE
AXL-154-M103L
AXL
Monomethyl auristatin E
Mc-Val-Cit-PABC
[252]
AXL-171-MMAE
AXL-171
AXL
Monomethyl auristatin E
Mc-Val-Cit-PABC
[252]
AXL-183-N52Q-MMAE
AXL-183-N52Q
AXL
Monomethyl auristatin E
Mc-Val-Cit-PABC
[252]
AXL-511-MMAE
AXL-511
AXL
Monomethyl auristatin E
Mc-Val-Cit-PABC
[252]
AXL-613-MMAE
AXL-613
AXL
Monomethyl auristatin E
Mc-Val-Cit-PABC
[252]
AXL-726-M101L-MMAE
AXL-726-M101L
AXL
Monomethyl auristatin E
Mc-Val-Cit-PABC
[252]
AXL-733-MMAE
AXL-733
AXL
Monomethyl auristatin E
Mc-Val-Cit-PABC
[252]
B10 225-M-vc-MMAE
B10 225-M
EGFR; MET
Monomethyl auristatin E
Mc-Val-Cit-PABC
[253]
B10v5 225-H-vc-MMAE
B10v5 225-H
EGFR; MET
Monomethyl auristatin E
Mc-Val-Cit-PABC
[253]
B10v5 225-M-vc-MMAE
B10v5 225-M
EGFR; MET
Monomethyl auristatin E
Mc-Val-Cit-PABC
[253]
B7H3-MMAE
Undisclosed
CD276
Monomethyl auristatin E
Undisclosed
[254]
BA03-MCC-MMAE
BA03
EGFR
Monomethyl auristatin E
Mc-Val-Cit-PABC
[255]
BA03-MC-MMAE
BA03
EGFR
Monomethyl auristatin E
Mc-Val-Cit-PABC
[255]
BA-3361
Undisclosed
NECTIN4
Monomethyl auristatin E
Mc-Val-Cit-PABC
[256]
B-B4-DM1
Cantuzumab
SDC1
Mertansine DM1
Undisclosed
[257]
B-B4-SMCC-DM1
Anti-CD138 mAb B-B4
SDC1
Mertansine DM1
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
[258]
B-B4-SPDB-DM4
Anti-CD138 mAb B-B4
SDC1
Mertansine DM4
N-succinimidyl 4-(2-pyridyldithio) butanoate (SPDB)
[258]
B-B4-SPP-DM1
Anti-CD138 mAb B-B4
SDC1
Mertansine DM1
N-succinimidyl 4-(2-pyridyldithio) pentanoate (SPP)
[258]
BCG022
Undisclosed
ERBB3; MET
Monomethyl auristatin E
Undisclosed
[259]
BCG033
Undisclosed
TACSTD2; PTK7
Monomethyl auristatin E
Undisclosed
[260]
BCMA-024
Undisclosed
TNFRSF17
Duostatin 5.2
Proprietary Concortis linker
[261]
BCMA-077
Undisclosed
TNFRSF17
Duostatin 5.2
Proprietary Concortis linker
[261]
Bevacizumab vedotin
Bevacizumab
VEGFA
Monomethyl auristatin E
Mc-Val-Cit-PABC
[262]
Bevacizumab-Compound 17
Bevacizumab
VEGFA
Mertansine DM4
Bevacizumab-Compound 17 linker
[200]
Bevacizumab-Compound 25
Bevacizumab
VEGFA
Monomethyl auristatin E
Bevacizumab-Compound 25 linker
[200]
Bevacizumab-Compound 31
Bevacizumab
VEGFA
Auristatin 0101
Bevacizumab-Compound 31 linker
[200]
Bevacizumab-Compound 36
Bevacizumab
VEGFA
Monomethyl auristatin E
Bevacizumab-Compound 36 linker
[200]
Bevacizumab-Compound 55
Bevacizumab
VEGFA
Mertansine DM1
Bevacizumab-Compound 55 linker
[200]
Bevacizumab-Compound 59
Bevacizumab
VEGFA
Mertansine DM4
Bevacizumab-Compound 59 linker
[200]
Bevacizumab-Compound 64
Bevacizumab
VEGFA
Monomethyl auristatin E
Bevacizumab-Compound 64 linker
[200]
Bevacizumab-Compound 69
Bevacizumab
VEGFA
Monomethyl auristatin E
Bevacizumab-Compound 69 linker
[200]
Bevacizumab-Compound 75
Bevacizumab
VEGFA
Monomethyl auristatin E
Bevacizumab-Compound 75 linker
[200]
Bevacizumab-Compound 76
Bevacizumab
VEGFA
Monomethyl auristatin E
Bevacizumab-Compound 76 linker
[200]
Bevacizumab-Compound 77
Bevacizumab
VEGFA
Mertansine DM1
Bevacizumab-Compound 77 linker
[200]
Bevacizumab-Compound 78
Bevacizumab
VEGFA
Auristatin 0101
Bevacizumab-Compound 78 linker
[200]
Bevacizumab-Compound 79
Bevacizumab
VEGFA
Auristatin 0101
Bevacizumab-Compound 79 linker
[200]
Bevacizumab-Compound 80
Bevacizumab
VEGFA
Mertansine DM4
Bevacizumab-Compound 80 linker
[200]
Bevacizumab-Compound 9
Bevacizumab
VEGFA
Mertansine DM1
Bevacizumab-Compound 9 linker
[200]
Bispecific nBT062-natalizumab-DM4
Bispecific nBT062-natalizumab
SDC1; ITGA4
Mertansine DM4
N-succinimidyl 4-(2-pyridyldithio) butanoate (SPDB)
[263]
Blinatumomab-2i
Blinatumomab
CD19; CD3D
Monomethyl auristatin F
Blinatumomab-2i linker
[208]
Blinatumomab-3i
Blinatumomab
CD19; CD3D
Monomethyl auristatin F
Blinatumomab-3i linker
[208]
Blinatumomab-4i
Blinatumomab
CD19; CD3D
Monomethyl auristatin F
Blinatumomab-4i linker
[208]
Blinatumomab-6e
Blinatumomab
CD19; CD3D
Monomethyl auristatin E
Blinatumomab-6e linker
[208]
Blinatumomab-Compound 17
Blinatumomab
CD19; CD3D
Mertansine DM4
Blinatumomab-Compound 17 linker
[200]
Blinatumomab-Compound 25
Blinatumomab
CD19; CD3D
Monomethyl auristatin E
Blinatumomab-Compound 25 linker
[200]
Blinatumomab-Compound 31
Blinatumomab
CD19; CD3D
Auristatin 0101
Blinatumomab-Compound 31 linker
[200]
Blinatumomab-Compound 36
Blinatumomab
CD19; CD3D
Monomethyl auristatin E
Blinatumomab-Compound 36 linker
[200]
Blinatumomab-Compound 55
Blinatumomab
CD19; CD3D
Mertansine DM1
Blinatumomab-Compound 55 linker
[200]
Blinatumomab-Compound 59
Blinatumomab
CD19; CD3D
Mertansine DM4
Blinatumomab-Compound 59 linker
[200]
Blinatumomab-Compound 64
Blinatumomab
CD19; CD3D
Monomethyl auristatin E
Blinatumomab-Compound 64 linker
[200]
Blinatumomab-Compound 69
Blinatumomab
CD19; CD3D
Monomethyl auristatin E
Blinatumomab-Compound 69 linker
[200]
Blinatumomab-Compound 75
Blinatumomab
CD19; CD3D
Monomethyl auristatin E
Blinatumomab-Compound 75 linker
[200]
Blinatumomab-Compound 76
Blinatumomab
CD19; CD3D
Monomethyl auristatin E
Blinatumomab-Compound 76 linker
[200]
Blinatumomab-Compound 77
Blinatumomab
CD19; CD3D
Mertansine DM1
Blinatumomab-Compound 77 linker
[200]
Blinatumomab-Compound 78
Blinatumomab
CD19; CD3D
Auristatin 0101
Blinatumomab-Compound 78 linker
[200]
Blinatumomab-Compound 79
Blinatumomab
CD19; CD3D
Auristatin 0101
Blinatumomab-Compound 79 linker
[200]
Blinatumomab-Compound 80
Blinatumomab
CD19; CD3D
Mertansine DM4
Blinatumomab-Compound 80 linker
[200]
Blinatumomab-Compound 9
Blinatumomab
CD19; CD3D
Mertansine DM1
Blinatumomab-Compound 9 linker
[200]
Brentuximab-7
Brentuximab
TNFRSF8
Monomethyl auristatin E
Alkyl phosphoramide-PEG12-Val-Cit-PAB
[264]
Brentuximab-8
Brentuximab
TNFRSF8
Monomethyl auristatin E
Alkyl phosphoramide-PEG24-Val-Cit-PAB
[264]
Brentuximab-Compound 17
Brentuximab
TNFRSF8
Mertansine DM4
Brentuximab-Compound 17 linker
[200]
Brentuximab-Compound 25
Brentuximab
TNFRSF8
Monomethyl auristatin E
Brentuximab-Compound 25 linker
[200]
Brentuximab-Compound 31
Brentuximab
TNFRSF8
Auristatin 0101
Brentuximab-Compound 31 linker
[200]
Brentuximab-Compound 36
Brentuximab
TNFRSF8
Monomethyl auristatin E
Brentuximab-Compound 36 linker
[200]
Brentuximab-Compound 55
Brentuximab
TNFRSF8
Mertansine DM1
Brentuximab-Compound 55 linker
[200]
Brentuximab-Compound 59
Brentuximab
TNFRSF8
Mertansine DM4
Brentuximab-Compound 59 linker
[200]
Brentuximab-Compound 64
Brentuximab
TNFRSF8
Monomethyl auristatin E
Brentuximab-Compound 64 linker
[200]
Brentuximab-Compound 69
Brentuximab
TNFRSF8
Monomethyl auristatin E
Brentuximab-Compound 69 linker
[200]
Brentuximab-Compound 75
Brentuximab
TNFRSF8
Monomethyl auristatin E
Brentuximab-Compound 75 linker
[200]
Brentuximab-Compound 76
Brentuximab
TNFRSF8
Monomethyl auristatin E
Brentuximab-Compound 76 linker
[200]
Brentuximab-Compound 77
Brentuximab
TNFRSF8
Mertansine DM1
Brentuximab-Compound 77 linker
[200]
Brentuximab-Compound 78
Brentuximab
TNFRSF8
Auristatin 0101
Brentuximab-Compound 78 linker
[200]
Brentuximab-Compound 79
Brentuximab
TNFRSF8
Auristatin 0101
Brentuximab-Compound 79 linker
[200]
Brentuximab-Compound 80
Brentuximab
TNFRSF8
Mertansine DM4
Brentuximab-Compound 80 linker
[200]
Brentuximab-Compound 9
Brentuximab
TNFRSF8
Mertansine DM1
Brentuximab-Compound 9 linker
[200]
BSA01
Undisclosed
EGFR; MUC1
Monomethyl auristatin E
Undisclosed
[265]
Bstrongximab ADC
Bstrongximab
Undisclosed
Monomethyl auristatin E
Mc-Val-Cit-PABC
[266]
BT062-SMCC-DM1
Indatuximab
SDC1
Mertansine DM1
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
[267]
BT062-SPDB-DM4
Indatuximab
SDC1
Mertansine DM4
N-succinimidyl 4-(2-pyridyldithio) butanoate (SPDB)
[267]
BT062-SPP-DM1
Indatuximab
SDC1
Mertansine DM1
N-succinimidyl 4-(2-pyridyldithio) pentanoate (SPP)
[267]
BVD-TEM8 ADC
Anti-TEM8 mAb m825
ANTXR1
Monomethyl auristatin E
Mc-Val-Cit-PABC
[268]
C12G1-DM1
Anti-NECTIN2 mAb c12G1
NECTIN2
Mertansine DM1
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
[191]
CAC10-Gly5-MAY
Brentuximab
TNFRSF8
Mertansine DM1
Gly5
[269]
C-ADC
Trastuzumab
ERBB2
Monomethyl auristatin E
Divinylpyrimidine-PEG4-Val-Ala-PABC
[270]
CBR96-Phe-Lys-MMAE
Anti-Lewis-Y mAb cBR96
Undisclosed
Monomethyl auristatin E
Mc-Phe-Lys-PABC
[271]
CBT-3112
Undisclosed
DCLK1
Paclitaxel
Undisclosed
[272]
CBX-13
Undisclosed
Undisclosed
Mertansine DM4
Undisclosed
[273]
CBX-15
Undisclosed
PARP1
Monomethyl auristatin E
Undisclosed
[273]
CC2B-h15H3-gluc-MMAE
Anti-ITGA5 mAb CC2B-h15H3
ITGA5
Monomethyl auristatin E
Quaternary ammonium linker Gluc
[274]
CD38-077
STI-5171
CD38
Duostatin 5.2
Non-polyethylene glycol linker
[275]
CD46 CAB-ADC
Undisclosed
CD46
Monomethyl auristatin E
Mc-Val-Cit-PABC
[276]
CD46-ADC
Anti-CD46 mAb 23AG2
CD46
Monomethyl auristatin F
Mc-Val-Cit-PABC
[277]
CD4-Val-Cit-MMAE
Anti-CD4 mAb
CD4
Monomethyl auristatin E
Mc-Val-Cit-PABC
[278]
CD70-MMAF-ADC
Vorsetuzumab
CD70
Monomethyl auristatin F
Maleimido-caproyl
[279]
CDH6-SPDB-DM4
Human Anti-CDH6 mAb
CDH6
Mertansine DM4
N-succinimidyl 4-(2-pyridyldithio) butanoate (SPDB)
[280]
CDX3379-MMAE
CDX3379
ERBB3
Monomethyl auristatin E
Mc-Val-Cit-PABC
[281]
Cet-DM1
Cetuximab
EGFR
Mertansine DM1
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
[282]
Cetux Fab-vc-MMAE
Cetuximab Fab (conjugate to glycan residues)
EGFR
Monomethyl auristatin E
Mc-Val-Cit-PABC
[171]
Cetuximab (LC) G7-CVIM-3i
Cetuximab (LC) G7-CVIM
EGFR
Monomethyl auristatin F
Cetuximab(LC) G7-CVIM-3i linker
[205]
Cetuximab (LC) G7-CVIM-4i
Cetuximab (LC) G7-CVIM
EGFR
Monomethyl auristatin F
Cetuximab(LC) G7-CVIM-4i linker
[205]
Cetuximab (LC) G7-CVIM-6e
Cetuximab (LC) G7-CVIM
EGFR
Monomethyl auristatin E
Cetuximab(LC) G7-CVIM-6e linker
[205]
Cetuximab (LC)-2i
Cetuximab (LC)
EGFR
Monomethyl auristatin F
Cetuximab(LC)-2i linker
[205]
Cetuximab (LC)-3i
Cetuximab (LC)
EGFR
Monomethyl auristatin F
Cetuximab(LC)-3i linker
[205]
Cetuximab (LC)-4i
Cetuximab (LC)
EGFR
Monomethyl auristatin F
Cetuximab(LC)-4i linker
[205]
Cetuximab (LC)-6e
Cetuximab (LC)
EGFR
Monomethyl auristatin E
Cetuximab(LC)-6e linker
[205]
Cetuximab (LV) G7-CVIM-3i
Cetuximab (LV) G7-CVIM
EGFR
Monomethyl auristatin F
Cetuximab(LV) G7-CVIM-3i linker
[205]
Cetuximab (LV) G7-CVIM-4i
Cetuximab (LV) G7-CVIM
EGFR
Monomethyl auristatin F
Cetuximab(LV) G7-CVIM-4i linker
[205]
Cetuximab (LV) G7-CVIM-6e
Cetuximab (LV) G7-CVIM
EGFR
Monomethyl auristatin E
Cetuximab(LV) G7-CVIM-6e linker
[205]
Cetuximab-Compound 17
Cetuximab
EGFR
Mertansine DM4
Cetuximab-Compound 17 linker
[200]
Cetuximab-Compound 25
Cetuximab
EGFR
Monomethyl auristatin E
Cetuximab-Compound 25 linker
[200]
Cetuximab-Compound 31
Cetuximab
EGFR
Auristatin 0101
Cetuximab-Compound 31 linker
[200]
Cetuximab-Compound 36
Cetuximab
EGFR
Monomethyl auristatin E
Cetuximab-Compound 36 linker
[200]
Cetuximab-Compound 55
Cetuximab
EGFR
Mertansine DM1
Cetuximab-Compound 55 linker
[200]
Cetuximab-Compound 59
Cetuximab
EGFR
Mertansine DM4
Cetuximab-Compound 59 linker
[200]
Cetuximab-Compound 64
Cetuximab
EGFR
Monomethyl auristatin E
Cetuximab-Compound 64 linker
[200]
Cetuximab-Compound 69
Cetuximab
EGFR
Monomethyl auristatin E
Cetuximab-Compound 69 linker
[200]
Cetuximab-Compound 75
Cetuximab
EGFR
Monomethyl auristatin E
Cetuximab-Compound 75 linker
[200]
Cetuximab-Compound 76
Cetuximab
EGFR
Monomethyl auristatin E
Cetuximab-Compound 76 linker
[200]
Cetuximab-Compound 77
Cetuximab
EGFR
Mertansine DM1
Cetuximab-Compound 77 linker
[200]
Cetuximab-Compound 78
Cetuximab
EGFR
Auristatin 0101
Cetuximab-Compound 78 linker
[200]
Cetuximab-Compound 79
Cetuximab
EGFR
Auristatin 0101
Cetuximab-Compound 79 linker
[200]
Cetuximab-Compound 80
Cetuximab
EGFR
Mertansine DM4
Cetuximab-Compound 80 linker
[200]
Cetuximab-Compound 9
Cetuximab
EGFR
Mertansine DM1
Cetuximab-Compound 9 linker
[200]
Cetuximab-vc-MMAE
Cetuximab
EGFR
Monomethyl auristatin E
Mc-Val-Cit-PABC
[253]
C-Fab-MMAE
Cetuximab Fab
EGFR
Monomethyl auristatin E
Gly3-Val-Cit-PABC
[283]
Ch14.18-MMAE
Anti-GD2 mAb ch14.18
Undisclosed
Monomethyl auristatin E
Mc-Val-Cit-PABC
[284]
Ch14.18-MMAF
Anti-GD2 mAb ch14.18
Undisclosed
Monomethyl auristatin F
Mc-Val-Cit-PABC
[284]
ch735-Py-DM1
Chimeric human mAb ch735
Undisclosed
Mertansine DM1
TCO-PEG3-Mal
[285]
cHD37-2i
cHD37
CD19
Monomethyl auristatin F
cHD37-2i linker
[208]
cHD37-3i
cHD37
CD19
Monomethyl auristatin F
cHD37-3i linker
[208]
cHD37-4i
cHD37
CD19
Monomethyl auristatin F
cHD37-4i linker
[208]
cHD37-6e
cHD37
CD19
Monomethyl auristatin E
cHD37-6e linker
[208]
chmAb-A B7-H3-ADC
chmAb-A
CD276
Monomethyl auristatin E
Mc-Val-Cit-PABC
[286]
chmAb-B B7-H3-ADC
chmAb-B
CD276
Monomethyl auristatin E
Mc-Val-Cit-PABC
[286]
chmAb-C B7-H3-ADC
chmAb-C
CD276
Monomethyl auristatin E
Mc-Val-Cit-PABC
[286]
chmAb-D B7-H3-ADC
chmAb-D
CD276
Monomethyl auristatin E
Mc-Val-Cit-PABC
[286]
CHS5-Val-Cit-MMAE
Anti-MSLN IgG1-CHS5
MSLN
Monomethyl auristatin E
Mc-Val-Cit-PABC
[210]
CHS7-Val-Cit-MMAE
Anti-MSLN IgG1-CHS7
MSLN
Monomethyl auristatin E
Mc-Val-Cit-PABC
[210]
CHS8-Val-Cit-MMAE
Anti-MSLN IgG1-CHS8
MSLN
Monomethyl auristatin E
Mc-Val-Cit-PABC
[210]
C-IgG-Val-Cit-MMAE
Cetuximab
EGFR
Monomethyl auristatin E
Gly3-Val-Cit-PABC
[283]
Cirmtuzumab vedotin
Cirmtuzumab
ROR1
Monomethyl auristatin E
Lysine-linker
[287]
Cirmtuzumab-ADC-7
Cirmtuzumab
ROR1
Monomethyl auristatin E
Undisclosed
[288]
CLDN1 ADC
Anti-CLDN1 mAb 6F6
CLDN1
Monomethyl auristatin E
Undisclosed
[289]
CNTO95-DM1
CNTO95
ITGAV
Mertansine DM1
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
[172]
CNTO95-SPDB-DM4
CNTO95
ITGAV
Mertansine DM4
N-succinimidyl 4-(2-pyridyldithio) butanoate (SPDB)
[172]
CNTO95-SPP-DM1
CNTO95
ITGAV
Mertansine DM1
N-succinimidyl 4-(2-pyridyldithio) pentanoate (SPP)
[172]
CNTO95-SPP-DM4
CNTO95
ITGAV
Mertansine DM4
N-succinimidyl 4-(2-pyridyldithio) pentanoate (SPP)
[172]
CNTO95-SSNPB-DM4
CNTO95
ITGAV
Mertansine DM4
N-sulfosuccinimidyl-4-(5-nitro-2 pyridyldithio) butyrate (SSNPB)
[172]
CNTO95-SSNPP-DM4
CNTO95
ITGAV
Mertansine DM4
Sulfosuccinimidyl-N-succinimidyl-4-(5-nitro-2-pyridyldithio) pentanoate (SSNPP)
[172]
Crown Ether ADC 4a
Brentuximab
TNFRSF8
Monomethyl auristatin E
6-Amino-alpha-cyclodextrin-Val-Cit-PABC
[290]
Crown Ether ADC 4b
Brentuximab
TNFRSF8
Monomethyl auristatin E
6-Amino-beta-cyclodextrin-Val-Cit-PABC
[290]
Crown Ether ADC 4c
Brentuximab
TNFRSF8
Monomethyl auristatin E
6-Amino-gama-cyclodextrin-Val-Cit-PABC
[290]
Crown Ether ADC 4d
Brentuximab
TNFRSF8
Monomethyl auristatin E
3-Amino-alpha-cyclodextrin-Val-Cit-PABC
[290]
Crown Ether ADC 4e
Brentuximab
TNFRSF8
Monomethyl auristatin E
3-Amino-beta-cyclodextrin-Val-Cit-PABC
[290]
Crown Ether ADC 4f
Brentuximab
TNFRSF8
Monomethyl auristatin E
3-Amino-gama-cyclodextrin-Val-Cit-PABC
[290]
Crown Ether ADC 5a
Brentuximab
TNFRSF8
Monomethyl auristatin E
1-Aza-24-crown-8-Val-Cit-PABC
[290]
Crown Ether ADC 5b
Brentuximab
TNFRSF8
Monomethyl auristatin E
1-Aza-42-crown-14-Val-Cit-PABC
[290]
Crown Ether ADC 6a
Brentuximab
TNFRSF8
Monomethyl auristatin E
PEG(8u)-Val-Cit-PABC
[290]
Crown Ether ADC 6b
Brentuximab
TNFRSF8
Monomethyl auristatin E
PEG(24u)-Val-Cit-PABC
[290]
CTAT-ADC
Undisclosed
ERBB2
Mertansine DM1
Undisclosed
[291]
CTX-MMAE
Cetuximab
EGFR
Monomethyl auristatin E
PD-Val-Cit-PABC
[292]
Cys-linker-MMAE-based ADC 11
Mil40
ERBB2
Monomethyl auristatin E
Cys-11 ADC linker
[293]
Cys-linker-MMAE-based ADC 12
Mil40
ERBB2
Monomethyl auristatin E
Cys-12 ADC linker
[293]
Cys-linker-MMAE-based ADC 13
Mil40
ERBB2
Monomethyl auristatin E
Cys-13 ADC linker
[293]
Cys-linker-MMAE-based ADC 14
Mil40
ERBB2
Monomethyl auristatin E
Cys-14 ADC linker
[293]
Cys-linker-MMAE-based ADC 15
Mil40
ERBB2
Monomethyl auristatin E
Mc-PABC
[293]
Cys-linker-MMAE-based ADC 16
Mil40
ERBB2
Monomethyl auristatin E
Mc-Val-Cit-PABC
[293]
DAB4-DM1
DAB4
SSB
Mertansine DM1
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
[294]
DAB4-DM4
DAB4
SSB
Mertansine DM4
N-succinimidyl 4-(2-pyridyldithio) butanoate (SPDB)
[294]
DAB4-MMAE
DAB4
SSB
Monomethyl auristatin E
Mc-Val-Cit-PABC
[294]
DAB4-MMAF
DAB4
SSB
Monomethyl auristatin F
Mc-Val-Cit-PABC
[294]
DAN-405
Undisclosed
FOLH1
Cabazitaxel
Undisclosed
[295]
DAR2-ARC-ADC
Human hCLL-1 Anti-ody genetically fused with CD38
COLEC10
Monomethyl auristatin F
NAD-based dinucleotide linker
[296]
DAR4-ARC-ADC
Undisclosed
COLEC10
Monomethyl auristatin F
NAD-based dinucleotide linker
[296]
DAR8-alphaCD30-mDPR-Gluc-DMTub
Anti-CD30 DAR8-alphaCD30-mDPR-gluc-DMTub mAb
TNFRSF8
DMTub
Quaternary ammonium linker Gluc
[297]
DAR8-alphaCD30-mDPR-Gluc-MMAE
Anti-CD30 DAR8-alphaCD30-mDPR-gluc-MMAE mAb
TNFRSF8
Monomethyl auristatin E
Quaternary ammonium linker Gluc
[297]
DAR8-alphaCD30-mDPR-GlucQ-AE
Anti-CD30 DAR8-alphaCD30-mDPR-glucQ-AE mAb
TNFRSF8
Auristatin E
Quaternary ammonium linker GlucQ
[297]
DAR8-alphaCD30-mDPR-GlucQ-Tub
Anti-CD30 DAR8-alphaCD30-mDPR-glucQ-Tub mAb
TNFRSF8
Tubulysin analogue 3
Quaternary ammonium linker GlucQ
[297]
Denintuzumab-2i
Denintuzumab
CD19
Monomethyl auristatin F
Denintuzumab-2i linker
[208]
Denintuzumab-3i
Denintuzumab
CD19
Monomethyl auristatin F
Denintuzumab-3i linker
[208]
Denintuzumab-4i
Denintuzumab
CD19
Monomethyl auristatin F
Denintuzumab-4i linker
[208]
Denintuzumab-6e
Denintuzumab
CD19
Monomethyl auristatin E
Denintuzumab-6e linker
[208]
DL35D-DM1
DL35D
env; env
Mertansine DM1
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
[298]
DM003
Undisclosed
PTK7; EGFR
Monomethyl auristatin E
Undisclosed
[299]
DM004
Undisclosed
TPBG; MET
Monomethyl auristatin E
Undisclosed
[300]
Docetaxel-trastuzumab
Trastuzumab
ERBB2
Docetaxel
Undisclosed
[301]
DS6-DM1
Anti-MUC1 mAb DS6
MUC1
Mertansine DM1
N-succinimidyl 4-(2-pyridyldithio) butanoate (SPDB)
[302]
EDB-ADC
Anti-EDB-FN L19
FN1
Auristatin 0101
Mc-Val-Cit-PABC
[303]
EGFR ADC-21
Cetuximab
EGFR
Monomethyl auristatin E
Vinylsulfonamide based linker 15
[304]
EGFR ADC-22
Cetuximab
EGFR
Monomethyl auristatin E
Vinylsulfonamide based linker 16
[304]
EGFR ADC-23
Cetuximab
EGFR
Monomethyl auristatin E
Vinylsulfonamide based linker 17
[304]
EGFR-MMAU ADC
Cetuximab
EGFR
Glucuronyl-monomethyl-auristatin E (MMAU)
Mc-Val-Cit-PABC
[305]
EGFRvIII-16
Anti-EGFRvIII mAb
EGFRvIII
DM1 derivative 16
Mc-Val-Cit-PABC
[306]
EGFRvIII-MCC-DM1
Anti-EGFRvIII mAb
EGFRvIII
Mertansine DM1
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
[306]
Erbitux-MHT-71
Cetuximab
EGFR
Auristatin F
MHT-71
[307]
Eribulin ADC (Jiangsu hengrui)
Undisclosed
Undisclosed
Eribulin
Undisclosed
[308]
EV20/MMAF
EV20
ERBB3
Monomethyl auristatin F
Maleimido-caproyl
[309]
EVCit ADC 3c
Anti-HER2 mAb glutamine 295 (Q295)
ERBB2
Monomethyl auristatin F
DBCO-PEG-EVCit-PABC
[310]
F105-DM1
F105
ITGAV
Mertansine DM1
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
[172]
F105-SPP-DM1
F105
ITGAV
Mertansine DM1
N-succinimidyl 4-(2-pyridyldithio) pentanoate (SPP)
[172]
F105-SPP-DM4
F105
ITGAV
Mertansine DM4
N-succinimidyl 4-(2-pyridyldithio) pentanoate (SPP)
[172]
F105-SSNPP-DM4
F105
ITGAV
Mertansine DM4
Sulfosuccinimidyl-N-succinimidyl-4-(5-nitro-2-pyridyldithio) pentanoate (SSNPP)
[172]
F7-ADC
F7-Chimeric Ab
FZD7
Monomethyl auristatin E
Mc-Val-Cit-PABC
[311]
Farletuzumab-3-sulfo-Mal-DM4
Farletuzumab
FOLR1
Mertansine DM4
3-sulfo-Mal
[312]
Farletuzumab-PEG4-Mal-DM1
Farletuzumab
FOLR1
Mertansine DM1
PEG4-Mal
[312]
Farletuzumab-PEG4-Mal-DM4
Farletuzumab
FOLR1
Mertansine DM4
PEG4-Mal
[312]
Farletuzumab-SIA-DM1
Farletuzumab
FOLR1
Mertansine DM1
N-succinimidyl iodoacetate (SIA)
[312]
Farletuzumab-SMCC-DM1
Farletuzumab
FOLR1
Mertansine DM1
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
[312]
Farletuzumab-SPDB-DM4
Farletuzumab
FOLR1
Mertansine DM4
N-succinimidyl 4-(2-pyridyldithio) butanoate (SPDB)
[312]
Farletuzumab-SPP-DM1
Farletuzumab
FOLR1
Mertansine DM1
N-succinimidyl 4-(2-pyridyldithio) pentanoate (SPP)
[312]
Farletuzumab-sulfo SPDB-DM4
Farletuzumab
FOLR1
Mertansine DM4
Sulfo-SPDB
[313]
Farletuzumab-sulfo-SPDB-DM4
Farletuzumab
FOLR1
Mertansine DM4
Sulfo-SPDB
[312]
Fcab-1-MMAE
Fcab-1
EGFR
Monomethyl auristatin E
Gly3-Val-Cit-PABC
[283]
Fcab-2-MMAE
Fcab-2
EGFR
Monomethyl auristatin E
Gly3-Val-Cit-PABC
[283]
Fcab-3-MMAE
Fcab-3
EGFR
Monomethyl auristatin E
Gly3-Val-Cit-PABC
[283]
FGM-TTZ-MMAE
Trastuzumab
ERBB2
Monomethyl auristatin E
Mc-Val-Cit-PABC
[314]
FMOD-ADC
Anti-FMOD mAb
FMOD
Mertansine DM1
Sulfo-SMCC
[315]
FOLR1-Mal-Caproyl-Val-Cit-PABC-Eribulin
Farletuzumab
FOLR1
Eribulin
Maleimide-Caproyl-Val-Cit-PABC
[313]
FOLR1-Mal-Caproyl-Val-Cit-PABC-MMAE
Farletuzumab
FOLR1
Monomethyl auristatin E
Maleimide-Caproyl-Val-Cit-PABC
[313]
FOLR1-Mal-Caproyl-Val-Cit-PABC-MMAF
Farletuzumab
FOLR1
Monomethyl auristatin F
Maleimide-Caproyl-Val-Cit-PABC
[313]
FOLR1-Mal-PEG2-Ala-Ala-Asn-PABC-Eribulin
Farletuzumab
FOLR1
Eribulin
Mal-PEG2-Ala-Ala-Asn-PABC
[313]
FOLR1-Mal-PEG2-Eribulin
Farletuzumab
FOLR1
Eribulin
Mal-PEG2
[313]
FOLR1-Mal-PEG2-Val-Cit-PABC-Eribulin
Farletuzumab
FOLR1
Eribulin
Mal-PEG2-Val-Cit-PABC
[313]
FOLR1-Mal-PEG4-Eribulin
Farletuzumab
FOLR1
Eribulin
Mal-PEG4
[313]
FOLR1-Mal-PEG4-tria-PEG3-Dis-dim-PABC-Eribulin
Farletuzumab
FOLR1
Eribulin
Mal-PEG4-triazole-PEG3-Disulfidyl-dimethyl-PABC
[313]
FOLR1-Mal-PEG4-tria-PEG3-Sulfo-Eribulin
Farletuzumab
FOLR1
Eribulin
Mal-PEG4-triazole-PEG3-Sulfonamide
[313]
FOLR1-Mal-PEG8-Val-Cit-PABC-Eribulin
Farletuzumab
FOLR1
Eribulin
Mal-PEG8-Val-Cit-PABC
[313]
FOLR1-Mal-PEG-Val-Cit-PABC-Cryptophycin
Farletuzumab
FOLR1
Cryptophycin
Mal-PEG-Val-Cit-PABC
[313]
FOLR1-Suc/SPAAC-PEG2-Eribulin
Farletuzumab
FOLR1
Eribulin
Succinamide-SPAAC-PEG2
[313]
FOLR1-Suc/SPAAC-PEG3-Dis-dim-PABC-Eribulin
Farletuzumab
FOLR1
Eribulin
Succinamide-SPAAC-PEG3-Disylfidyl-dimethyl-PABC
[313]
FOLR1-Suc/SPAAC-PEG3-Sulfonamide-Eribulin
Farletuzumab
FOLR1
Eribulin
Succinamide-SPAAC-PEG3-Sulfonamide
[313]
FOLR1-Suc/SPAAC-PEG4-Eribulin
Farletuzumab
FOLR1
Eribulin
Succinamide-SPAAC-PEG4
[313]
FOLR1-Suc/SPAAC-PEG4-Val-Cit-PABC-Eribulin
Farletuzumab
FOLR1
Eribulin
Succinamide-SPAAC-PEG4-Val-Cit-PABC
[313]
FR1-21-3-sulfo-Mal-DM4
FR1-21
FOLR1
Mertansine DM4
3-sulfo-Mal
[312]
FR1-21-PEG4-Mal-DM1
FR1-21
FOLR1
Mertansine DM1
PEG4-Mal
[312]
FR1-21-PEG4-Mal-DM4
FR1-21
FOLR1
Mertansine DM4
PEG4-Mal
[312]
FR1-21-SIA-DM1
FR1-21
FOLR1
Mertansine DM1
N-succinimidyl iodoacetate (SIA)
[312]
FR1-21-SMCC-DM1
FR1-21
FOLR1
Mertansine DM1
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
[312]
FR1-21-SPDB-DM4
FR1-21
FOLR1
Mertansine DM4
N-succinimidyl 4-(2-pyridyldithio) butanoate (SPDB)
[312]
FR1-21-SPP-DM1
FR1-21
FOLR1
Mertansine DM1
N-succinimidyl 4-(2-pyridyldithio) pentanoate (SPP)
[312]
FR1-21-sulfo-SPDB-DM4
FR1-21
FOLR1
Mertansine DM4
Sulfo-SPDB
[312]
FR1-48-3-sulfo-Mal-DM4
FR1-48
FOLR1
Mertansine DM4
3-sulfo-Mal
[312]
FR1-48-PEG4-Mal-DM1
FR1-48
FOLR1
Mertansine DM1
PEG4-Mal
[312]
FR1-48-PEG4-Mal-DM4
FR1-48
FOLR1
Mertansine DM4
PEG4-Mal
[312]
FR1-48-SIA-DM1
FR1-48
FOLR1
Mertansine DM1
N-succinimidyl iodoacetate (SIA)
[312]
FR1-48-SMCC-DM1
FR1-48
FOLR1
Mertansine DM1
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
[312]
FR1-48-SPDB-DM4
FR1-48
FOLR1
Mertansine DM4
N-succinimidyl 4-(2-pyridyldithio) butanoate (SPDB)
[312]
FR1-48-SPP-DM1
FR1-48
FOLR1
Mertansine DM1
N-succinimidyl 4-(2-pyridyldithio) pentanoate (SPP)
[312]
FR1-48-sulfo-SPDB-DM4
FR1-48
FOLR1
Mertansine DM4
Sulfo-SPDB
[312]
FR1-49-3-sulfo-Mal-DM4
FR1-49
FOLR1
Mertansine DM4
3-sulfo-Mal
[312]
FR1-49-PEG4-Mal-DM1
FR1-49
FOLR1
Mertansine DM1
PEG4-Mal
[312]
FR1-49-PEG4-Mal-DM4
FR1-49
FOLR1
Mertansine DM4
PEG4-Mal
[312]
FR1-49-SIA-DM1
FR1-49
FOLR1
Mertansine DM1
N-succinimidyl iodoacetate (SIA)
[312]
FR1-49-SMCC-DM1
FR1-49
FOLR1
Mertansine DM1
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
[312]
FR1-49-SPDB-DM4
FR1-49
FOLR1
Mertansine DM4
N-succinimidyl 4-(2-pyridyldithio) butanoate (SPDB)
[312]
FR1-49-SPP-DM1
FR1-49
FOLR1
Mertansine DM1
N-succinimidyl 4-(2-pyridyldithio) pentanoate (SPP)
[312]
FR1-49-sulfo-SPDB-DM4
FR1-49
FOLR1
Mertansine DM4
Sulfo-SPDB
[312]
FR1-57-3-sulfo-Mal-DM4
FR1-57
FOLR1
Mertansine DM4
3-sulfo-Mal
[312]
FR1-57-PEG4-Mal-DM1
FR1-57
FOLR1
Mertansine DM1
PEG4-Mal
[312]
FR1-57-PEG4-Mal-DM4
FR1-57
FOLR1
Mertansine DM4
PEG4-Mal
[312]
FR1-57-SIA-DM1
FR1-57
FOLR1
Mertansine DM1
N-succinimidyl iodoacetate (SIA)
[312]
FR1-57-SMCC-DM1
FR1-57
FOLR1
Mertansine DM1
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
[312]
FR1-57-SPDB-DM4
FR1-57
FOLR1
Mertansine DM4
N-succinimidyl 4-(2-pyridyldithio) butanoate (SPDB)
[312]
FR1-57-SPP-DM1
FR1-57
FOLR1
Mertansine DM1
N-succinimidyl 4-(2-pyridyldithio) pentanoate (SPP)
[312]
FR1-57-sulfo-SPDB-DM4
FR1-57
FOLR1
Mertansine DM4
Sulfo-SPDB
[312]
FR1-65-3-sulfo-Mal-DM4
FR1-65
FOLR1
Mertansine DM4
3-sulfo-Mal
[312]
FR1-65-PEG4-Mal-DM1
FR1-65
FOLR1
Mertansine DM1
PEG4-Mal
[312]
FR1-65-PEG4-Mal-DM4
FR1-65
FOLR1
Mertansine DM4
PEG4-Mal
[312]
FR1-65-SIA-DM1
FR1-65
FOLR1
Mertansine DM1
N-succinimidyl iodoacetate (SIA)
[312]
FR1-65-SMCC-DM1
FR1-65
FOLR1
Mertansine DM1
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
[312]
FR1-65-SPDB-DM4
FR1-65
FOLR1
Mertansine DM4
N-succinimidyl 4-(2-pyridyldithio) butanoate (SPDB)
[312]
FR1-65-SPP-DM1
FR1-65
FOLR1
Mertansine DM1
N-succinimidyl 4-(2-pyridyldithio) pentanoate (SPP)
[312]
FR1-65-sulfo-SPDB-DM4
FR1-65
FOLR1
Mertansine DM4
Sulfo-SPDB
[312]
GABRP Ab-DM1 ADC
GABRP-Ab
GABRP
Mertansine DM1
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
[316]
GB7008-01-Val-Cit-MMAE
GB7008-01
CLDN6
Monomethyl auristatin E
Mc-Val-Cit-PABC
[317]
GBR401-2i
GBR401
CD19
Monomethyl auristatin F
GBR401-2i linker
[208]
GBR401-3i
GBR401
CD19
Monomethyl auristatin F
GBR401-3i linker
[208]
GBR401-4i
GBR401
CD19
Monomethyl auristatin F
GBR401-4i linker
[208]
GBR401-6e
GBR401
CD19
Monomethyl auristatin E
GBR401-6e linker
[208]
Gemtuzumab-Compound 17
Gemtuzumab
CD33
Mertansine DM4
Gemtuzumab-Compound 17 linker
[200]
Gemtuzumab-Compound 25
Gemtuzumab
CD33
Monomethyl auristatin E
Gemtuzumab-Compound 25 linker
[200]
Gemtuzumab-Compound 31
Gemtuzumab
CD33
Auristatin 0101
Gemtuzumab-Compound 31 linker
[200]
Gemtuzumab-Compound 36
Gemtuzumab
CD33
Monomethyl auristatin E
Gemtuzumab-Compound 36 linker
[200]
Gemtuzumab-Compound 55
Gemtuzumab
CD33
Mertansine DM1
Gemtuzumab-Compound 55 linker
[200]
Gemtuzumab-Compound 59
Gemtuzumab
CD33
Mertansine DM4
Gemtuzumab-Compound 59 linker
[200]
Gemtuzumab-Compound 64
Gemtuzumab
CD33
Monomethyl auristatin E
Gemtuzumab-Compound 64 linker
[200]
Gemtuzumab-Compound 69
Gemtuzumab
CD33
Monomethyl auristatin E
Gemtuzumab-Compound 69 linker
[200]
Gemtuzumab-Compound 75
Gemtuzumab
CD33
Monomethyl auristatin E
Gemtuzumab-Compound 75 linker
[200]
Gemtuzumab-Compound 76
Gemtuzumab
CD33
Monomethyl auristatin E
Gemtuzumab-Compound 76 linker
[200]
Gemtuzumab-Compound 77
Gemtuzumab
CD33
Mertansine DM1
Gemtuzumab-Compound 77 linker
[200]
Gemtuzumab-Compound 78
Gemtuzumab
CD33
Auristatin 0101
Gemtuzumab-Compound 78 linker
[200]
Gemtuzumab-Compound 79
Gemtuzumab
CD33
Auristatin 0101
Gemtuzumab-Compound 79 linker
[200]
Gemtuzumab-Compound 80
Gemtuzumab
CD33
Mertansine DM4
Gemtuzumab-Compound 80 linker
[200]
Gemtuzumab-Compound 9
Gemtuzumab
CD33
Mertansine DM1
Gemtuzumab-Compound 9 linker
[200]
GENA-111-AF
GENA-111
TNFRSF17
Monomethyl auristatin F
Undisclosed
[318]
Glyco-cetuximab Fab-vc-MMAE
Glyco-engineered cetuximab Fab
EGFR
Monomethyl auristatin E
Mc-Val-Cit-PABC
[171]
GMF-1A3-MMAE
Anti-cleaved-AREG 1A3 Anti-ody
AREG
Monomethyl auristatin E
Mc-Val-Cit-PABC
[319]
Golimumab-Compound 17
Golimumab
TNF
Mertansine DM4
Golimumab-Compound 17 linker
[200]
Golimumab-Compound 25
Golimumab
TNF
Monomethyl auristatin E
Golimumab-Compound 25 linker
[200]
Golimumab-Compound 31
Golimumab
TNF
Auristatin 0101
Golimumab-Compound 31 linker
[200]
Golimumab-Compound 36
Golimumab
TNF
Monomethyl auristatin E
Golimumab-Compound 36 linker
[200]
Golimumab-Compound 55
Golimumab
TNF
Mertansine DM1
Golimumab-Compound 55 linker
[200]
Golimumab-Compound 59
Golimumab
TNF
Mertansine DM4
Golimumab-Compound 59 linker
[200]
Golimumab-Compound 64
Golimumab
TNF
Monomethyl auristatin E
Golimumab-Compound 64 linker
[200]
Golimumab-Compound 69
Golimumab
TNF
Monomethyl auristatin E
Golimumab-Compound 69 linker
[200]
Golimumab-Compound 75
Golimumab
TNF
Monomethyl auristatin E
Golimumab-Compound 75 linker
[200]
Golimumab-Compound 76
Golimumab
TNF
Monomethyl auristatin E
Golimumab-Compound 76 linker
[200]
Golimumab-Compound 77
Golimumab
TNF
Mertansine DM1
Golimumab-Compound 77 linker
[200]
Golimumab-Compound 78
Golimumab
TNF
Auristatin 0101
Golimumab-Compound 78 linker
[200]
Golimumab-Compound 79
Golimumab
TNF
Auristatin 0101
Golimumab-Compound 79 linker
[200]
Golimumab-Compound 80
Golimumab
TNF
Mertansine DM4
Golimumab-Compound 80 linker
[200]
Golimumab-Compound 9
Golimumab
TNF
Mertansine DM1
Golimumab-Compound 9 linker
[200]
GPC-1 ADC 1
Anti-GPC1 mAb 01a033
GPC1
Monomethyl auristatin F
Mc-Val-Cit-PABC
[320]
GPC-1 ADC 10
Anti-GPC1 mAb 01a021
GPC1
Monomethyl auristatin F
Mc-Val-Cit-PABC
[320]
GPC-1 ADC 11
Anti-GPC1 mAb 02a022
GPC1
Monomethyl auristatin F
Mc-Val-Cit-PABC
[320]
GPC-1 ADC 12
Anti-GPC1 mAb 01a009
GPC1
Monomethyl auristatin F
Mc-Val-Cit-PABC
[320]
GPC-1 ADC 13
Anti-GPC1 mAb 01a030
GPC1
Monomethyl auristatin F
Mc-Val-Cit-PABC
[320]
GPC-1 ADC 14
Anti-GPC1 mAb 01a017
GPC1
Monomethyl auristatin F
Mc-Val-Cit-PABC
[320]
GPC-1 ADC 15
Anti-GPC1 mAb 01a007
GPC1
Monomethyl auristatin F
Mc-Val-Cit-PABC
[320]
GPC-1 ADC 16
Anti-GPC1 mAb 01a042
GPC1
Monomethyl auristatin F
Mc-Val-Cit-PABC
[320]
GPC-1 ADC 17
Anti-GPC1 mAb 01a026
GPC1
Monomethyl auristatin F
Mc-Val-Cit-PABC
[320]
GPC-1 ADC 18
Anti-GPC1 mAb 02a006
GPC1
Monomethyl auristatin F
Mc-Val-Cit-PABC
[320]
GPC-1 ADC 2
Anti-GPC1 mAb 01a002
GPC1
Monomethyl auristatin F
Mc-Val-Cit-PABC
[320]
GPC-1 ADC 3
Anti-GPC1 mAb 02a035
GPC1
Monomethyl auristatin F
Mc-Val-Cit-PABC
[320]
GPC-1 ADC 4
Anti-GPC1 mAb 02a034
GPC1
Monomethyl auristatin F
Mc-Val-Cit-PABC
[320]
GPC-1 ADC 5
Anti-GPC1 mAb 02a014
GPC1
Monomethyl auristatin F
Mc-Val-Cit-PABC
[320]
GPC-1 ADC 6
Anti-GPC1 mAb 02a002
GPC1
Monomethyl auristatin F
Mc-Val-Cit-PABC
[320]
GPC-1 ADC 7
Anti-GPC1 mAb 02a010
GPC1
Monomethyl auristatin F
Mc-Val-Cit-PABC
[320]
GPC-1 ADC 8
Anti-GPC1 mAb 01a016
GPC1
Monomethyl auristatin F
Mc-Val-Cit-PABC
[320]
GPC-1 ADC 9
Anti-GPC1 mAb 02b006
GPC1
Monomethyl auristatin F
Mc-Val-Cit-PABC
[320]
GPC-1-ADC
Anti-GPC1 mAb clone 01a033
GPC1
Monomethyl auristatin F
Mc-Val-Cit-PABC
[321]
GPC1-ADC-MMAE
Anti-GPC1 GPC1-ADC (MMAE) mAb
GPC1
Monomethyl auristatin E
Mc-Val-Cit-PABC
[322]
GPC1-ADC-MMAF
Anti-GPC1 GPC1-ADC mAb
GPC1
Monomethyl auristatin F
Mc-Val-Cit-PABC
[323]
H01L02-DM4
Anti-CDH6 mAb H01L02
CDH6
Mertansine DM4
Sulfo-SPDB
[324]
h15H3-gluc-MMAE
Anti-ITGA5 mAb h15H3
ITGA5
Monomethyl auristatin E
Quaternary ammonium linker Gluc
[274]
h1F6-1 MMAE DAR4
Vorsetuzumab
CD70
Monomethyl auristatin E
Phe-Dpr-MA
[325]
h1F6-1 MMAE DAR8
Vorsetuzumab
CD70
Monomethyl auristatin E
Phe-Dpr-MA
[325]
h1F6-1 MMAF
Vorsetuzumab
CD70
Monomethyl auristatin F
Phe-Dpr-MA
[325]
h1F6-10 MMAE
Vorsetuzumab
CD70
Monomethyl auristatin E
Thr-Glu-EDA-MDpr
[325]
h1F6-10 MMAF
Vorsetuzumab
CD70
Monomethyl auristatin F
Thr-Glu-EDA-MDpr
[325]
h1F6-11 MMAE
Vorsetuzumab
CD70
Monomethyl auristatin E
Phe-Ile-EDA-MDpr
[325]
h1F6-11 MMAE DAR8
Vorsetuzumab
CD70
Monomethyl auristatin E
Phe-Ile-EDA-MDpr
[325]
h1F6-11 MMAF
Vorsetuzumab
CD70
Monomethyl auristatin F
Phe-Ile-EDA-MDpr
[325]
h1F6-12 MMAE DAR4
Vorsetuzumab
CD70
Monomethyl auristatin E
Thr-Ile-EDA-MDpr
[325]
h1F6-12 MMAE DAR8
Vorsetuzumab
CD70
Monomethyl auristatin E
Thr-Ile-EDA-MDpr
[325]
h1F6-12 MMAF
Vorsetuzumab
CD70
Monomethyl auristatin F
Thr-Ile-EDA-MDpr
[325]
h1F6-13 MMAE DAR4
Vorsetuzumab
CD70
Monomethyl auristatin E
Thiazole-Glu-EDA-MDpr
[325]
h1F6-13 MMAE DAR8
Vorsetuzumab
CD70
Monomethyl auristatin E
Thiazole-Glu-EDA-MDpr
[325]
h1F6-13 MMAF
Vorsetuzumab
CD70
Monomethyl auristatin F
Thiazole-Glu-EDA-MDpr
[325]
h1F6-14 MMAE
Vorsetuzumab
CD70
Monomethyl auristatin E
Asp-Ala-Lys-MDpr
[325]
h1F6-14 MMAF
Vorsetuzumab
CD70
Monomethyl auristatin F
Asp-Ala-Lys-MDpr
[325]
h1F6-15 MMAE
Vorsetuzumab
CD70
Monomethyl auristatin E
Glu-Ala-Lys-MDpr
[325]
h1F6-15 MMAF
Vorsetuzumab
CD70
Monomethyl auristatin F
Glu-Ala-Lys-MDpr
[325]
h1F6-16 MMAE
Vorsetuzumab
CD70
Monomethyl auristatin E
PhosphoThr-Ala-Lys-MDpr
[325]
h1F6-16 MMAF
Vorsetuzumab
CD70
Monomethyl auristatin F
PhosphoThr-Ala-Lys-MDpr
[325]
h1F6-17 MMAE
Vorsetuzumab
CD70
Monomethyl auristatin E
Asn-AlaGlu-Dpr-MDpr
[325]
h1F6-17 MMAE DAR4
Vorsetuzumab
CD70
Monomethyl auristatin E
Asn-AlaGlu-Dpr-MDpr
[325]
h1F6-17 MMAF
Vorsetuzumab
CD70
Monomethyl auristatin F
Asn-AlaGlu-Dpr-MDpr
[325]
h1F6-18 MMAE
Vorsetuzumab
CD70
Monomethyl auristatin E
Glu-Ala-Glu-Dpr-MDpr
[325]
h1F6-18 MMAF
Vorsetuzumab
CD70
Monomethyl auristatin F
Glu-Ala-Glu-Dpr-MDpr
[325]
h1F6-19 MMAE
Vorsetuzumab
CD70
Monomethyl auristatin E
Asp-AlaGlu-Dpr-MDpr
[325]
h1F6-19 MMAF
Vorsetuzumab
CD70
Monomethyl auristatin F
Asp-AlaGlu-Dpr-MDpr
[325]
h1F6-2 MMAE DAR4
Vorsetuzumab
CD70
Monomethyl auristatin E
Phe-Glu-Dpr-MA
[325]
h1F6-2 MMAE DAR8
Vorsetuzumab
CD70
Monomethyl auristatin E
Phe-Glu-Dpr-MA
[325]
h1F6-2 MMAF
Vorsetuzumab
CD70
Monomethyl auristatin F
Phe-Glu-Dpr-MA
[325]
h1F6-20 MMAE
Vorsetuzumab
CD70
Monomethyl auristatin E
Glu-Ala-Glu-Dpr-MDpr
[325]
h1F6-20 MMAE DAR4
Vorsetuzumab
CD70
Monomethyl auristatin E
Glu-Ala-Glu-Dpr-MDpr
[325]
h1F6-20 MMAF
Vorsetuzumab
CD70
Monomethyl auristatin F
Glu-Ala-Glu-Dpr-MDpr
[325]
h1F6-21 MMAE
Vorsetuzumab
CD70
Monomethyl auristatin E
hSer-Ala-Glu-Dpr-MDpr
[325]
h1F6-21 MMAF
Vorsetuzumab
CD70
Monomethyl auristatin F
hSer-Ala-Glu-Dpr-MDpr
[325]
h1F6-22 MMAE
Vorsetuzumab
CD70
Monomethyl auristatin E
ValoH-AlaGlu-Dpr-MDpr
[325]
h1F6-22 MMAF
Vorsetuzumab
CD70
Monomethyl auristatin F
ValoH-AlaGlu-Dpr-MDpr
[325]
h1F6-23 MMAE
Vorsetuzumab
CD70
Monomethyl auristatin E
PhosphoThr-Ala-Glu-Dpr-MDpr
[325]
h1F6-23 MMAF
Vorsetuzumab
CD70
Monomethyl auristatin F
PhosphoThr-Ala-Glu-Dpr-MDpr
[325]
h1F6-24 MMAE
Vorsetuzumab
CD70
Monomethyl auristatin E
Pyrazole-Glu-Dpr-MDpr
[325]
h1F6-24 MMAE DAR4
Vorsetuzumab
CD70
Monomethyl auristatin E
Pyrazole-Glu-Dpr-MDpr
[325]
h1F6-24 MMAF
Vorsetuzumab
CD70
Monomethyl auristatin F
Pyrazole-Glu-Dpr-MDpr
[325]
h1F6-25 MMAE
Vorsetuzumab
CD70
Monomethyl auristatin E
Triazole-Glu-Dpr-MDpr
[325]
h1F6-25 MMAF
Vorsetuzumab
CD70
Monomethyl auristatin F
Triazole-Glu-Dpr-MDpr
[325]
h1F6-26 MMAE
Vorsetuzumab
CD70
Monomethyl auristatin E
Asn-Glu-Dpr-MDpr
[325]
h1F6-26 MMAF
Vorsetuzumab
CD70
Monomethyl auristatin F
Asn-Glu-Dpr-MDpr
[325]
h1F6-27 MMAE
Vorsetuzumab
CD70
Monomethyl auristatin E
Asp-Glu-Dpr-MDpr
[325]
h1F6-27 MMAF
Vorsetuzumab
CD70
Monomethyl auristatin F
Asp-Glu-Dpr-MDpr
[325]
h1F6-28 MMAE
Vorsetuzumab
CD70
Monomethyl auristatin E
Fur-Glu-Dpr-MDpr
[325]
h1F6-28 MMAF
Vorsetuzumab
CD70
Monomethyl auristatin F
Fur-Glu-Dpr-MDpr
[325]
h1F6-29 MMAE
Vorsetuzumab
CD70
Monomethyl auristatin E
ValOH-Glu-Dpr-MDpr
[325]
h1F6-29 MMAE DAR4
Vorsetuzumab
CD70
Monomethyl auristatin E
ValOH-Glu-Dpr-MDpr
[325]
h1F6-29 MMAF
Vorsetuzumab
CD70
Monomethyl auristatin F
ValOH-Glu-Dpr-MDpr
[325]
h1F6-3 MMAE DAR4
Vorsetuzumab
CD70
Monomethyl auristatin E
Thr-Dpr-MA
[325]
h1F6-3 MMAE DAR8
Vorsetuzumab
CD70
Monomethyl auristatin E
Thr-Dpr-MA
[325]
h1F6-3 MMAF
Vorsetuzumab
CD70
Monomethyl auristatin F
Thr-Dpr-MA
[325]
h1F6-30 MMAE
Vorsetuzumab
CD70
Monomethyl auristatin E
Ser-Glu-Dpr-MDpr
[325]
h1F6-30 MMAF
Vorsetuzumab
CD70
Monomethyl auristatin F
Ser-Glu-Dpr-MDpr
[325]
h1F6-31 MMAE
Vorsetuzumab
CD70
Monomethyl auristatin E
hSer-Glu-Dpr-MDpr
[325]
h1F6-31 MMAF
Vorsetuzumab
CD70
Monomethyl auristatin F
hSer-Glu-Dpr-MDpr
[325]
h1F6-32 MMAE
Vorsetuzumab
CD70
Monomethyl auristatin E
Thr-IleLeu-Dpr-MDpr
[325]
h1F6-32 MMAF
Vorsetuzumab
CD70
Monomethyl auristatin F
Thr-IleLeu-Dpr-MDpr
[325]
h1F6-33 MMAE
Vorsetuzumab
CD70
Monomethyl auristatin E
Phe-Ile-Leu-Dpr-MDpr
[325]
h1F6-33 MMAF
Vorsetuzumab
CD70
Monomethyl auristatin F
Phe-Ile-Leu-Dpr-MDpr
[325]
h1F6-34 MMAE
Vorsetuzumab
CD70
Monomethyl auristatin E
Glu-Phe-Leu-Dpr-MDpr
[325]
h1F6-34 MMAF
Vorsetuzumab
CD70
Monomethyl auristatin F
Glu-Phe-Leu-Dpr-MDpr
[325]
h1F6-35 MMAE
Vorsetuzumab
CD70
Monomethyl auristatin E
Thr-LeuPhe-Dpr-MDpr
[325]
h1F6-35 MMAF
Vorsetuzumab
CD70
Monomethyl auristatin F
Thr-LeuPhe-Dpr-MDpr
[325]
h1F6-36 MMAE
Vorsetuzumab
CD70
Monomethyl auristatin E
Phe-Leu-Phe-Dpr-MDpr
[325]
h1F6-36 MMAF
Vorsetuzumab
CD70
Monomethyl auristatin F
Phe-Leu-Phe-Dpr-MDpr
[325]
h1F6-37 MMAE
Vorsetuzumab
CD70
Monomethyl auristatin E
Glu-Phe-Phe-Dpr-MDpr
[325]
h1F6-37 MMAF
Vorsetuzumab
CD70
Monomethyl auristatin F
Glu-Phe-Phe-Dpr-MDpr
[325]
h1F6-38 MMAE
Vorsetuzumab
CD70
Monomethyl auristatin E
Thr-LysAla-Dpr-MDpr
[325]
h1F6-38 MMAF
Vorsetuzumab
CD70
Monomethyl auristatin F
Thr-LysAla-Dpr-MDpr
[325]
h1F6-39 MMAE
Vorsetuzumab
CD70
Monomethyl auristatin E
Thr-Lys-Dpr-MDpr
[325]
h1F6-39 MMAF
Vorsetuzumab
CD70
Monomethyl auristatin F
Thr-Lys-Dpr-MDpr
[325]
h1F6-4 MMAE DAR4
Vorsetuzumab
CD70
Monomethyl auristatin E
Thr-Glu-Dpr-MA
[325]
h1F6-4 MMAE DAR8
Vorsetuzumab
CD70
Monomethyl auristatin E
Thr-Glu-Dpr-MA
[325]
h1F6-4 MMAF
Vorsetuzumab
CD70
Monomethyl auristatin F
Thr-Glu-Dpr-MA
[325]
h1F6-5 MMAE DAR4
Vorsetuzumab
CD70
Monomethyl auristatin E
Phe-Glu-Dpr-MDpr
[325]
h1F6-5 MMAE DAR8
Vorsetuzumab
CD70
Monomethyl auristatin E
Phe-Glu-Dpr-MDpr
[325]
h1F6-5 MMAF
Vorsetuzumab
CD70
Monomethyl auristatin F
Phe-Glu-Dpr-MDpr
[325]
h1F6-6 MMAE DAR4
Vorsetuzumab
CD70
Monomethyl auristatin E
Thr-Glu-Dpr-MDpr
[325]
h1F6-6 MMAE DAR8
Vorsetuzumab
CD70
Monomethyl auristatin E
Thr-Glu-Dpr-MDpr
[325]
h1F6-6 MMAF
Vorsetuzumab
CD70
Monomethyl auristatin F
Thr-Glu-Dpr-MDpr
[325]
h1F6-7 MMAE DAR4
Vorsetuzumab
CD70
Monomethyl auristatin E
Thr-Glu-Lys-MDpr
[325]
h1F6-7 MMAE DAR8
Vorsetuzumab
CD70
Monomethyl auristatin E
Thr-Glu-Lys-MDpr
[325]
h1F6-7 MMAF
Vorsetuzumab
CD70
Monomethyl auristatin F
Thr-Glu-Lys-MDpr
[325]
h1F6-8 MMAE
Vorsetuzumab
CD70
Monomethyl auristatin E
Thiazole-Glu-Lys-MDpr
[325]
h1F6-8 MMAF
Vorsetuzumab
CD70
Monomethyl auristatin F
Thiazole-Glu-Lys-MDpr
[325]
h1F6-9 MMAE
Vorsetuzumab
CD70
Monomethyl auristatin E
Phe-Glu-EDA-MDpr
[325]
h1F6-9 MMAF
Vorsetuzumab
CD70
Monomethyl auristatin F
Phe-Glu-EDA-MDpr
[325]
h1F6-mcMMAF
Vorsetuzumab
CD70
Monomethyl auristatin F
Maleimido-caproyl
[325]
h1F6-MC-vc-PABC-MMAE
Vorsetuzumab
CD70
Monomethyl auristatin E
Mc-Val-Cit-PABC
[325]
h1F6-MC-vc-PABC-MMAF DAR4
Vorsetuzumab
CD70
Monomethyl auristatin E
Mc-Val-Cit-PABC
[325]
h1F6-MC-vc-PABC-MMAF DAR8
Vorsetuzumab
CD70
Monomethyl auristatin E
Mc-Val-Cit-PABC
[325]
H-1-vcMMAE
Anti-HER2 mAb H-1
ERBB2
Monomethyl auristatin E
Mc-Val-Cit-PABC
[326]
H32-DM1_3.0
Anti-HER2 mAb H32
ERBB2
Mertansine DM1
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
[327]
H32-DM1_3.3
Anti-HER2 mAb H32
ERBB2
Mertansine DM1
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
[327]
H32-DM1_3.7
Anti-HER2 mAb H32
ERBB2
Mertansine DM1
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
[327]
H32-DM1_3.8
Anti-HER2 mAb H32
ERBB2
Mertansine DM1
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
[327]
H32-VCMMAE_2.1
Anti-HER2 mAb H32
ERBB2
Monomethyl auristatin E
Mc-Val-Cit-PABC
[327]
H32-VCMMAE_3.2
Anti-HER2 mAb H32
ERBB2
Monomethyl auristatin E
Mc-Val-Cit-PABC
[327]
H32-VCMMAE_3.8
Anti-HER2 mAb H32
ERBB2
Monomethyl auristatin E
Mc-Val-Cit-PABC
[327]
H32-VCMMAE_6.6
Anti-HER2 mAb H32
ERBB2
Monomethyl auristatin E
Mc-Val-Cit-PABC
[327]
h3G10.1.91-h3G10.2.72 vc0101
h3G10.1.91-h3G10.2.72
CXCR4
Auristatin 0101
Mc-Val-Cit-PABC
[173]
h3G10.1.91-h3G10.2.72 vcMMAD
h3G10.1.91-h3G10.2.72
CXCR4
Monomethyl auristatin D
Mc-Val-Cit-PABC
[173]
h3G10.2.37-h3G10.2.72 vc0101
h3G10.2.37-h3G10.2.72
CXCR4
Auristatin 0101
Mc-Val-Cit-PABC
[173]
h3G10.2.37-h3G10.2.72 vcMMAD
h3G10.2.37-h3G10.2.72
CXCR4
Monomethyl auristatin D
Mc-Val-Cit-PABC
[173]
h3G10.A57-h3G10 vc0101
h3G10.A57-h3G10
CXCR4
Auristatin 0101
Mc-Val-Cit-PABC
[173]
h3G10.A57-h3G10 vcMMAD
h3G10.A57-h3G10
CXCR4
Monomethyl auristatin D
Mc-Val-Cit-PABC
[173]
h3G10.A57-h3G10.2.72 vc0101
h3G10.A57-h3G10.2.72
CXCR4
Auristatin 0101
Mc-Val-Cit-PABC
[173]
h3G10.A57-h3G10.2.72 vcMMAD
h3G10.A57-h3G10.2.72
CXCR4
Monomethyl auristatin D
Mc-Val-Cit-PABC
[173]
H3L2-mpeoDM1
Anti-DLL4 mAb H3L2
DLL4
Mertansine DM1
BIMPRO
[328]
H-3-vcMMAE
Anti-HER2 mAb H-3
ERBB2
Monomethyl auristatin E
Mc-Val-Cit-PABC
[326]
H-4-vcMMAE
Anti-HER2 mAb H-4
ERBB2
Monomethyl auristatin E
Mc-Val-Cit-PABC
[326]
H66 N297Q/S298N/Y300S-Mc-Val-Cit-PABC-MMAE
Anti-TRAC mAb H66 N297Q/S298N/Y300S
TRAC
Monomethyl auristatin E
Mc-Val-Cit-PABC
[177]
H66 S298N/T299A/Y300S-Mc-Val-Cit-PABC-MMAE
Anti-TRAC mAb H66 S298N/T299A/Y300S
TRAC
Monomethyl auristatin E
Mc-Val-Cit-PABC
[177]
H66 S298N/Y300S-Mc-Val-Cit-PABC-MMAE
Anti-TRAC mAb H66 S298N/Y300S
TRAC
Monomethyl auristatin E
Mc-Val-Cit-PABC
[177]
H66-Mc-Val-Cit-PABC-MMAE
Anti-TRAC mAb H66
TRAC
Monomethyl auristatin E
Mc-Val-Cit-PABC
[177]
HA15-10AC14E
Anti-SLITRK6 mAb Ha15-10ac14
SLITRK6
Monomethyl auristatin E
Mc-Val-Cit-PABC
[329]
HA15-10AC14F
Anti-SLITRK6 mAb Ha15-10ac14
SLITRK6
Monomethyl auristatin F
Maleimido-caproyl
[246]
HA15-1ABE16E
Anti-SLITRK6 mAb Ha15-1abe16
SLITRK6
Monomethyl auristatin E
Mc-Val-Cit-PABC
[329]
HA15-1ABE16F
Anti-SLITRK6 mAb Ha15-1abe16
SLITRK6
Monomethyl auristatin F
Maleimido-caproyl
[246]
HA15-1C25E
Anti-SLITRK6 mAb Ha15-1c25
SLITRK6
Monomethyl auristatin E
Mc-Val-Cit-PABC
[329]
HA15-1C25F
Anti-SLITRK6 mAb Ha15-1c25
SLITRK6
Monomethyl auristatin F
Maleimido-caproyl
[246]
Half nBT062-DM4
Indatuximab (C226S + C229S)
SDC1
Mertansine DM4
N-succinimidyl 4-(2-pyridyldithio) butanoate (SPDB)
[263]
HAZcPB-DM1
HAZcPB
MUC1
Mertansine DM1
N-succinimidyl 4-(2-pyridyldithio) pentanoate (SPP)
[184]
HB22.7-SAP
Anti-CD22 mAb HB22.7
CD22
Saporin
Undisclosed
[330]
hBU12-mc-MMAF
Anti-CD19 mAb hBU12
CD19
Monomethyl auristatin F
Mc-Val-Cit-PABC
[274]
HcHAb18-DM1
HcHAb18
BSG
Mertansine DM1
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
[331]
HER2 ADC-18
Trastuzumab
ERBB2
Monomethyl auristatin E
Vinylsulfonamide based linker 15
[304]
HER2 ADC-19
Trastuzumab
ERBB2
Monomethyl auristatin E
Vinylsulfonamide based linker 16
[304]
HER2 ADC-20
Trastuzumab
ERBB2
Monomethyl auristatin E
Vinylsulfonamide based linker 17
[304]
HER2 S298N/T299A/Y300S-Mc-Val-Cit-PABC-MMAE
Anti-HER2 mAb S298N/T299A/Y300S
ERBB2
Monomethyl auristatin E
Mc-Val-Cit-PABC
[177]
HER2 WT-Mc-Val-Cit-PABC-MMAE
Anti-HER2 mAb WT
ERBB2
Monomethyl auristatin E
Mc-Val-Cit-PABC
[177]
HER2-acetal-ADC 11
Trastuzumab
ERBB2
Monomethyl auristatin F
Clravable-acetal based linker 11
[332]
HER2-acetal-ADC 12
Trastuzumab
ERBB2
Monomethyl auristatin F
Clravable-TAMRA-acetal based linker 12
[332]
HER2-azide-alkyne MMAE conjugate
Trastuzumab
ERBB2
Monomethyl auristatin E
Azide-alkyne based linker 10a
[333]
HER2-cyclopropene-tetrazine MMAE conjugate
Trastuzumab
ERBB2
Monomethyl auristatin E
Cyclopropene-tetrazine based linker 10b
[333]
HER2-gsADC-1
CHO-S2G2F-Tras (Ab1)
ERBB2
Monomethyl auristatin E
ThioPz linker 6a
[334]
HER2-gsADC-10
Azido-tagged trastuzumab (Ab3)
ERBB2
Monomethyl auristatin E
PEGylation linker 6g
[334]
HER2-gsADC-11
Azido-tagged trastuzumab (Ab3)
ERBB2
Monomethyl auristatin E
PEGylation linker 6h
[334]
HER2-gsADC-12
Azido-tagged trastuzumab (Ab3)
ERBB2
Monomethyl auristatin E
PEGylation linker 6i
[334]
HER2-gsADC-13
Azido-tagged trastuzumab (Ab3)
ERBB2
Monomethyl auristatin E
PEGylation linker 6j
[334]
HER2-gsADC-14
Azido-tagged trastuzumab (Ab3)
ERBB2
Monomethyl auristatin E
PEGylation linker 6k
[334]
HER2-gsADC-15
Azido-tagged trastuzumab (Ab3)
ERBB2
Monomethyl auristatin E
PEGylation linker 6l
[334]
HER2-gsADC-16
Azido-tagged trastuzumab (Ab3)
ERBB2
Monomethyl auristatin E
PEGylation linker 6m
[334]
HER2-gsADC-17
Azido-tagged trastuzumab (Ab3)
ERBB2
Monomethyl auristatin E
Noncleavable linker 6t
[334]
HER2-gsADC-18
CHO-G2F-Tras (Ab4)
ERBB2
Monomethyl auristatin E
ThioPz linker 6a
[334]
HER2-gsADC-19
CHO-G2F-Tras (Ab4)
ERBB2
Monomethyl auristatin E
2-Aminobenzamide oxime
[334]
HER2-gsADC-2
CHO-S2G2F-Tras (Ab1)
ERBB2
Monomethyl auristatin E
2-Aminobenzamide oxime
[334]
HER2-gsADC-20
CHO-G2F-Tras (Ab4)
ERBB2
Monomethyl auristatin E
Hydroxylamine derivative 6c
[334]
HER2-gsADC-21
CHO-G2F-Tras (Ab4)
ERBB2
Monomethyl auristatin E
PEGylation linker 6n
[334]
HER2-gsADC-22
Azido-tagged trastuzumab (Ab5)
ERBB2
Monomethyl auristatin E
Linear alkyne 6f
[334]
HER2-gsADC-23
Azido-tagged trastuzumab (Ab5)
ERBB2
Monomethyl auristatin E
PEGylation linker 6g
[334]
HER2-gsADC-24
Azido-tagged trastuzumab (Ab5)
ERBB2
Monomethyl auristatin E
PEGylation linker 6h
[334]
HER2-gsADC-25
Azido-tagged trastuzumab (Ab5)
ERBB2
Monomethyl auristatin E
PEGylation linker 6i
[334]
HER2-gsADC-26
Azido-tagged trastuzumab (Ab5)
ERBB2
Monomethyl auristatin E
PEGylation linker 6j
[334]
HER2-gsADC-27
Azido-tagged trastuzumab (Ab5)
ERBB2
Monomethyl auristatin E
PEGylation linker 6k
[334]
HER2-gsADC-28
Azido-tagged trastuzumab (Ab5)
ERBB2
Monomethyl auristatin E
PEGylation linker 6l
[334]
HER2-gsADC-29
Azido-tagged trastuzumab (Ab5)
ERBB2
Monomethyl auristatin E
PEGylation linker 6m
[334]
HER2-gsADC-3
CHO-S2G2F-Tras (Ab1)
ERBB2
Monomethyl auristatin E
Hydroxylamine derivative 6c
[334]
HER2-gsADC-30
Azido-tagged trastuzumab (Ab5)
ERBB2
Monomethyl auristatin E
Glycosyl PEGylation linker 6o
[334]
HER2-gsADC-31
Azido-tagged trastuzumab (Ab5)
ERBB2
Monomethyl auristatin E
Glycosyl PEGylation linker 6p
[334]
HER2-gsADC-32
Azido-tagged trastuzumab (Ab5)
ERBB2
Monomethyl auristatin E
Glycosyl PEGylation linker 6q
[334]
HER2-gsADC-33
Azido-tagged trastuzumab (Ab5)
ERBB2
Monomethyl auristatin E
Glycosyl PEGylation linker 6r
[334]
HER2-gsADC-34
Azido-tagged trastuzumab (Ab6)
ERBB2
Monomethyl auristatin E
Linear alkyne 6f
[334]
HER2-gsADC-35
Azido-tagged trastuzumab (Ab6)
ERBB2
Monomethyl auristatin E
PEGylation linker 6g
[334]
HER2-gsADC-36
Azido-tagged trastuzumab (Ab6)
ERBB2
Monomethyl auristatin E
PEGylation linker 6h
[334]
HER2-gsADC-37
Azido-tagged trastuzumab (Ab6)
ERBB2
Monomethyl auristatin E
PEGylation linker 6i
[334]
HER2-gsADC-38
Azido-tagged trastuzumab (Ab6)
ERBB2
Monomethyl auristatin E
PEGylation linker 6j
[334]
HER2-gsADC-39
Azido-tagged trastuzumab (Ab6)
ERBB2
Monomethyl auristatin E
PEGylation linker 6k
[334]
HER2-gsADC-4
CHO-S2G2F-Tras (Ab1)
ERBB2
Monomethyl auristatin E
PEGylation linker 6n
[334]
HER2-gsADC-40
Azido-tagged trastuzumab (Ab6)
ERBB2
Monomethyl auristatin E
PEGylation linker 6l
[334]
HER2-gsADC-41
Az-LacNAc-Tras Ab7
ERBB2
Monomethyl auristatin E
Bicyclononyne derivative 6e
[334]
HER2-gsADC-42
Az-LacNAc-Tras Ab7
ERBB2
Monomethyl auristatin E
PEGylation linker 6l
[334]
HER2-gsADC-43
Az-LacNAc-Tras Ab7
ERBB2
Monomethyl auristatin E
PEGylation linker 6m
[334]
HER2-gsADC-44
Az-LacNAc-Tras Ab7
ERBB2
Monomethyl auristatin E
Noncleavable linker 6s
[334]
HER2-gsADC-45
Az-LacNAc-Tras Ab7
ERBB2
Monomethyl auristatin E
Noncleavable linker 6t
[334]
HER2-gsADC-46
Trastuzumab
ERBB2
Monomethyl auristatin E
ThioPz linker 6a
[334]
HER2-gsADC-47
Trastuzumab
ERBB2
Monomethyl auristatin E
Hydroxylamine derivative 6c
[334]
HER2-gsADC-48
Trastuzumab
ERBB2
Monomethyl auristatin E
2-Aminobenzamide oxime
[334]
HER2-gsADC-49
Trastuzumab
ERBB2
Monomethyl auristatin E
Azadibenzocylooctyne-amine derivative 6d
[334]
HER2-gsADC-5
Azido-tagged trastuzumab (Ab2)
ERBB2
Monomethyl auristatin E
Azadibenzocylooctyne-amine derivative 6d
[334]
HER2-gsADC-50
Trastuzumab
ERBB2
Monomethyl auristatin E
2-Aminobenzamidoxime without core-fucosylation
[334]
HER2-gsADC-6
Azido-tagged trastuzumab (Ab2)
ERBB2
Monomethyl auristatin E
Bicyclononyne derivative 6e
[334]
HER2-gsADC-7
Azido-tagged trastuzumab (Ab2)
ERBB2
Monomethyl auristatin E
PEGylation linker 6m
[334]
HER2-gsADC-8
Azido-tagged trastuzumab (Ab2)
ERBB2
Monomethyl auristatin E
Glycosyl PEGylation linker 6r
[334]
HER2-gsADC-9
Azido-tagged trastuzumab (Ab3)
ERBB2
Monomethyl auristatin E
Linear alkyne 6f
[334]
HER2-MMAU ADC
Trastuzumab
ERBB2
Glucuronyl-monomethyl-auristatin E (MMAU)
Mc-Val-Cit-PABC
[305]
HER2-norbornene-tetrazine MMAE conjugate
Trastuzumab
ERBB2
Monomethyl auristatin E
Norbornene-tetrazine based linker 10c
[333]
Hertuzumab vedotin
Hertuzumab
ERBB2
Monomethyl auristatin E
Mc-Val-Cit-PABC
[335]
hJAA-F11 ADC
JAA-F11
F3
Mertansine DM1
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
[336]
hL49_27D_Ala-ADC
hL49_27D_Ala
MELTF
Monomethyl auristatin E
mp-dLAE-PABC
[337]
hL49_27D_Gln-ADC
hL49_27D_Gln
MELTF
Monomethyl auristatin E
mp-dLAE-PABC
[337]
hL49_27D_Tyr-ADC
hL49_27D_Tyr
MELTF
Monomethyl auristatin E
mp-dLAE-PABC
[337]
hL49_34_Ala-ADC
hL49_34_Ala
MELTF
Monomethyl auristatin E
mp-dLAE-PABC
[337]
hL49_34_Gln-ADC
hL49_34_Gln
MELTF
Monomethyl auristatin E
mp-dLAE-PABC
[337]
hL49_34_Tyr-ADC
hL49_34_Tyr
MELTF
Monomethyl auristatin E
mp-dLAE-PABC
[337]
hL49_3x_Ala-ADC
hL49_3x_Ala
MELTF
Monomethyl auristatin E
mp-dLAE-PABC
[337]
hL49_3x_Gln-ADC
hL49_3x_Gln
MELTF
Monomethyl auristatin E
mp-dLAE-PABC
[337]
hL49_3x_Tyr-ADC
hL49_3x_Tyr
MELTF
Monomethyl auristatin E
mp-dLAE-PABC
[337]
hL49-ADC
Humanized Anti-CD228 SGN-CD228A mAb
MELTF
Monomethyl auristatin E
mp-dLAE-PABC
[337]
hu4DFabv7-BMPEO-DM1
hu4DFabv7
ERBB2
Maytansinoid DM1
hu4DFabv7-BMPEO-DM1 linker
[187]
hu4DFabv8 (A121C)-BMPEO-DM1
hu4DFabv8 (A121C)
ERBB2
Maytansinoid DM1
hu4DFabv8 (A121C)-BMPEO-DM1 linker
[187]
hu4DFabv8 (H-A175C)-BMPEO-DM1
hu4DFabv8 (H-A175C)
ERBB2
Maytansinoid DM1
hu4DFabv8 (H-A175C)-BMPEO-DM1 linker
[187]
hu4DFabv8 (H-A40C)-BMPEO-DM1
hu4DFabv8 (H-A40C)
ERBB2
Maytansinoid DM1
hu4DFabv8 (H-A40C)-BMPEO-DM1 linker
[187]
hu4DFabv8 (H-A88C)-BMPEO-DM1
hu4DFabv8 (H-A88C)
ERBB2
Maytansinoid DM1
hu4DFabv8 (H-A88C)-BMPEO-DM1 linker
[187]
hu4DFabv8 (H-S119C)-BMPEO-DM1
hu4DFabv8 (H-S119C)
ERBB2
Maytansinoid DM1
hu4DFabv8 (H-S119C)-BMPEO-DM1 linker
[187]
hu4DFabv8 (H-S122C)-BMPEO-DM1
hu4DFabv8 (H-S122C)
ERBB2
Maytansinoid DM1
hu4DFabv8 (H-S122C)-BMPEO-DM1 linker
[187]
hu4DFabv8 (H-S179C)-BMPEO-DM1
hu4DFabv8 (H-S179C)
ERBB2
Maytansinoid DM1
hu4DFabv8 (H-S179C)-BMPEO-DM1 linker
[187]
hu4DFabv8 (L-A144C)-BMPEO-DM1
hu4DFabv8 (L-A144C)
ERBB2
Maytansinoid DM1
hu4DFabv8 (L-A144C)-BMPEO-DM1 linker
[187]
hu4DFabv8 (L-A43C)-BMPEO-DM1
hu4DFabv8 (L-A43C)
ERBB2
Maytansinoid DM1
hu4DFabv8 (L-A43C)-BMPEO-DM1 linker
[187]
hu4DFabv8 (L-S168C)-BMPEO-DM1
hu4DFabv8 (L-S168C)
ERBB2
Maytansinoid DM1
hu4DFabv8 (L-S168C)-BMPEO-DM1 linker
[187]
hu4DFabv8 (L-V15C)-BMPEO-DM1
hu4DFabv8 (L-V15C)
ERBB2
Maytansinoid DM1
hu4DFabv8 (L-V15C)-BMPEO-DM1 linker
[187]
hu4DFabv8 (V110C)-BMPEO-DM1
hu4DFabv8 (V110C)
ERBB2
Maytansinoid DM1
hu4DFabv8 (V110C)-BMPEO-DM1 linker
[187]
hu4DFabv8 (V110C)-MC-MMAE
hu4DFabv8 (V110C)
ERBB2
Monomethyl auristatin E
Maleimido-caproyl
[187]
hu4DFabv8 (V110C)-MC-MMAF
hu4DFabv8 (V110C)
ERBB2
Monomethyl auristatin F
Maleimido-caproyl
[187]
hu4DFabv8 (V110C)-MC-Val-Cit-PAB-MMAE
hu4DFabv8 (V110C)
ERBB2
Monomethyl auristatin E
Mc-Val-Cit-PABC
[187]
hu4DFabv8 (V110C)-MC-Val-Cit-PAB-MMAF
hu4DFabv8 (V110C)
ERBB2
Monomethyl auristatin F
Mc-Val-Cit-PABC
[187]
HuAD208.14.1-vcMMAE-DAR4
huAD208.14.1
LRRC15
Monomethyl auristatin E
Mc-Val-Cit-PABC
[338]
HuAD208.4.1-vcMMAE-DAR4
huAD208.4.1
LRRC15
Monomethyl auristatin E
Mc-Val-Cit-PABC
[338]
huDS6v1.01-DM4
huDS6v1.01
MUC1
Mertansine DM4
N-succinimidyl 4-(2-pyridyldithio) butanoate (SPDB)
[184]
huDS6v1.21-DM4
huDS6v1.21
MUC1
Mertansine DM4
N-succinimidyl 4-(2-pyridyldithio) butanoate (SPDB)
[184]
HuFc-MMAE
Anti-EGFR huFc
EGFR
Monomethyl auristatin E
Gly3-Val-Cit-PABC
[283]
huFR1-21-3-sulfo-Mal-DM4
huFR1-21
FOLR1
Mertansine DM4
3-sulfo-Mal
[312]
huFR1-21-PEG4-Mal-DM1
huFR1-21
FOLR1
Mertansine DM1
PEG4-Mal
[312]
huFR1-21-PEG4-Mal-DM4
huFR1-21
FOLR1
Mertansine DM4
PEG4-Mal
[312]
huFR1-21-SIA-DM1
huFR1-21
FOLR1
Mertansine DM1
N-succinimidyl iodoacetate (SIA)
[312]
huFR1-21-SMCC-DM1
huFR1-21
FOLR1
Mertansine DM1
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
[312]
huFR1-21-SPDB-DM4
huFR1-21
FOLR1
Mertansine DM4
N-succinimidyl 4-(2-pyridyldithio) butanoate (SPDB)
[312]
huFR1-21-SPP-DM1
huFR1-21
FOLR1
Mertansine DM1
N-succinimidyl 4-(2-pyridyldithio) pentanoate (SPP)
[312]
huFR1-21-sulfo-SPDB-DM4
huFR1-21
FOLR1
Mertansine DM4
Sulfo-SPDB
[312]
huFR1-23-3-sulfo-Mal-DM4
huFR1-23
FOLR1
Mertansine DM4
3-sulfo-Mal
[312]
huFR1-23-PEG4-Mal-DM1
huFR1-23
FOLR1
Mertansine DM1
PEG4-Mal
[312]
huFR1-23-PEG4-Mal-DM4
huFR1-23
FOLR1
Mertansine DM4
PEG4-Mal
[312]
huFR1-23-SIA-DM1
huFR1-23
FOLR1
Mertansine DM1
N-succinimidyl iodoacetate (SIA)
[312]
huFR1-23-SMCC-DM1
huFR1-23
FOLR1
Mertansine DM1
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
[312]
huFR1-23-SPDB-DM4
huFR1-23
FOLR1
Mertansine DM4
N-succinimidyl 4-(2-pyridyldithio) butanoate (SPDB)
[312]
huFR1-23-SPP-DM1
huFR1-23
FOLR1
Mertansine DM1
N-succinimidyl 4-(2-pyridyldithio) pentanoate (SPP)
[312]
huFR1-23-sulfo-SPDB-DM4
huFR1-23
FOLR1
Mertansine DM4
Sulfo-SPDB
[312]
HuFR1-48-SMCC-DM1
Anti-FOLR1 huFR1-48
FOLR1
Mertansine DM1
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
[339]
HuFR1-49-SMCC-DM1
Anti-FOLR1 huFR1-49
FOLR1
Mertansine DM1
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
[339]
HuFR1-57-SMCC-DM1
Anti-FOLR1 huFR1-57
FOLR1
Mertansine DM1
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
[339]
HuFR1-65-SMCC-DM1
Anti-FOLR1 huFR1-65
FOLR1
Mertansine DM1
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
[339]
HuIgG1-SPDB-DM4
Undisclosed
FOLR1
Mertansine DM4
N-succinimidyl 4-(2-pyridyldithio) butanoate (SPDB)
[339]
HuM25-mcMMAF-E2
HuM25
LRRC15
Monomethyl auristatin F
Maleimido-caproyl
[338]
HuM25-vcMMAE-DAR4
HuM25
LRRC15
Monomethyl auristatin E
Mc-Val-Cit-PABC
[338]
HuM25-vcMMAE-E2
HuM25
LRRC15
Monomethyl auristatin E
Mc-Val-Cit-PABC
[338]
Humanized Anti-HER2 Mab-Maytansine Conjugate
Undisclosed
ERBB2
Mertansine DM1
Undisclosed
[340]
huMov19-3-sulfo-Mal-DM4 (DAR 3.7)
huMov19
FOLR1
Mertansine DM4
3-sulfo-Mal
[312]
huMov19-3-sulfo-Mal-DM4 (DAR 8.23)
huMov19
FOLR1
Mertansine DM4
3-sulfo-Mal
[312]
huMov19-PEG4-Mal-DM1
huMov19
FOLR1
Mertansine DM1
PEG4-Mal
[312]
huMov19-PEG4-Mal-DM4
huMov19
FOLR1
Mertansine DM4
PEG4-Mal
[312]
huMov19-SIA-DM1
huMov19
FOLR1
Mertansine DM1
N-succinimidyl iodoacetate (SIA)
[312]
huMov19-SMCC-DM1
huMov19
FOLR1
Mertansine DM1
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
[312]
huMov19-SPDB-DM4
huMov19
FOLR1
Mertansine DM4
N-succinimidyl 4-(2-pyridyldithio) butanoate (SPDB)
[312]
huMov19-SPP-DM1
huMov19
FOLR1
Mertansine DM1
N-succinimidyl 4-(2-pyridyldithio) pentanoate (SPP)
[312]
huMov19-sulfo-SPDB-DM4 (DAR3.8)
huMov19
FOLR1
Mertansine DM4
Sulfo-SPDB
[312]
huMov19-sulfo-SPDB-DM4 (DAR6.8)
huMov19
FOLR1
Mertansine DM4
Sulfo-SPDB
[312]
huMOV19v1.0-3-sulfo-Mal-DM4
huMOV19v1.0
FOLR1
Mertansine DM4
3-sulfo-Mal
[312]
huMOV19v1.0-PEG4-Mal-DM1
huMOV19v1.0
FOLR1
Mertansine DM1
PEG4-Mal
[312]
huMOV19v1.0-PEG4-Mal-DM4
huMOV19v1.0
FOLR1
Mertansine DM4
PEG4-Mal
[312]
huMOV19v1.0-SIA-DM1
huMOV19v1.0
FOLR1
Mertansine DM1
N-succinimidyl iodoacetate (SIA)
[312]
huMOV19v1.0-SMCC-DM1
huMOV19v1.0
FOLR1
Mertansine DM1
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
[312]
huMOV19v1.0-SPDB-DM4
huMOV19v1.0
FOLR1
Mertansine DM4
N-succinimidyl 4-(2-pyridyldithio) butanoate (SPDB)
[312]
huMOV19v1.0-SPP-DM1
huMOV19v1.0
FOLR1
Mertansine DM1
N-succinimidyl 4-(2-pyridyldithio) pentanoate (SPP)
[312]
huMOV19v1.0-sulfo-SPDB-DM4
huMOV19v1.0
FOLR1
Mertansine DM4
Sulfo-SPDB
[312]
huMOV19v1.6-3-sulfo-Mal-DM4
huMOV19v1.6
FOLR1
Mertansine DM4
3-sulfo-Mal
[312]
huMOV19v1.6-PEG4-Mal-DM1
huMOV19v1.6
FOLR1
Mertansine DM1
PEG4-Mal
[312]
huMOV19v1.6-PEG4-Mal-DM4
huMOV19v1.6
FOLR1
Mertansine DM4
PEG4-Mal
[312]
huMOV19v1.6-SIA-DM1
huMOV19v1.6
FOLR1
Mertansine DM1
N-succinimidyl iodoacetate (SIA)
[312]
huMOV19v1.6-SMCC-DM1
huMOV19v1.6
FOLR1
Mertansine DM1
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
[312]
huMOV19v1.6-SPDB-DM4
huMOV19v1.6
FOLR1
Mertansine DM4
N-succinimidyl 4-(2-pyridyldithio) butanoate (SPDB)
[312]
huMOV19v1.6-SPP-DM1
huMOV19v1.6
FOLR1
Mertansine DM1
N-succinimidyl 4-(2-pyridyldithio) pentanoate (SPP)
[312]
huMOV19v1.6-sulfo-SPDB-DM4
huMOV19v1.6
FOLR1
Mertansine DM4
Sulfo-SPDB
[312]
huPr1-vcMMAE
Anti-TMEFF2 mAb huPr1
TMEFF2
Monomethyl auristatin E
Mc-Val-Cit-PABC
[341]
HuRH105-SMCC-DM1
Undisclosed
ENG
Mertansine DM1
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
[342]
HuRH105-SSPDB-DM4
Undisclosed
ENG
Mertansine DM4
Sulfo-SPDB
[342]
HzMUC1-MMAE
HzMUC1
MUC1
Monomethyl auristatin E
Mc-Val-Cit-PABC
[343]
Ibritumomab-Compound 17
Ibritumomab
MS4A1
Mertansine DM4
Ibritumomab-Compound 17 linker
[200]
Ibritumomab-Compound 25
Ibritumomab
MS4A1
Monomethyl auristatin E
Ibritumomab-Compound 25 linker
[200]
Ibritumomab-Compound 31
Ibritumomab
MS4A1
Auristatin 0101
Ibritumomab-Compound 31 linker
[200]
Ibritumomab-Compound 36
Ibritumomab
MS4A1
Monomethyl auristatin E
Ibritumomab-Compound 36 linker
[200]
Ibritumomab-Compound 55
Ibritumomab
MS4A1
Mertansine DM1
Ibritumomab-Compound 55 linker
[200]
Ibritumomab-Compound 59
Ibritumomab
MS4A1
Mertansine DM4
Ibritumomab-Compound 59 linker
[200]
Ibritumomab-Compound 64
Ibritumomab
MS4A1
Monomethyl auristatin E
Ibritumomab-Compound 64 linker
[200]
Ibritumomab-Compound 69
Ibritumomab
MS4A1
Monomethyl auristatin E
Ibritumomab-Compound 69 linker
[200]
Ibritumomab-Compound 75
Ibritumomab
MS4A1
Monomethyl auristatin E
Ibritumomab-Compound 75 linker
[200]
Ibritumomab-Compound 76
Ibritumomab
MS4A1
Monomethyl auristatin E
Ibritumomab-Compound 76 linker
[200]
Ibritumomab-Compound 77
Ibritumomab
MS4A1
Mertansine DM1
Ibritumomab-Compound 77 linker
[200]
Ibritumomab-Compound 78
Ibritumomab
MS4A1
Auristatin 0101
Ibritumomab-Compound 78 linker
[200]
Ibritumomab-Compound 79
Ibritumomab
MS4A1
Auristatin 0101
Ibritumomab-Compound 79 linker
[200]
Ibritumomab-Compound 80
Ibritumomab
MS4A1
Mertansine DM4
Ibritumomab-Compound 80 linker
[200]
Ibritumomab-Compound 9
Ibritumomab
MS4A1
Mertansine DM1
Ibritumomab-Compound 9 linker
[200]
IC1-DM1
Chimeric ICAM1 Anti-ody (clone #R6.5)
ICAM1
Mertansine DM1
Mal-EBE-Mal
[344]
IC1-DM4
Chimeric ICAM1 Anti-ody (clone #R6.5)
ICAM1
Mertansine DM4
Mal-EBE-Mal
[344]
IC1-MMAE
Chimeric ICAM1 Anti-ody (clone #R6.5)
ICAM1
Monomethyl auristatin E
Mc-Val-Cit-PABC
[344]
IC1-MMAF
Chimeric ICAM1 Anti-ody (clone #R6.5)
ICAM1
Monomethyl auristatin F
Maleimido-caproyl
[344]
ICAM1-DM1 ADC
Anti-ICAM1 mAb
ICAM1
Mertansine DM1
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
[345]
IgG1 (GH2-20)-AL1-MMAE
Anti-HER2 IgG1(GH2-20)-AL1
ERBB2
Monomethyl auristatin E
Undisclosed
[346]
IgG1 (GH2-20)-vc-MMAE
Anti-HER2 IgG1(GH2-20)
ERBB2
Monomethyl auristatin E
Mc-Val-Cit-PABC
[346]
IgG1 (GH2-61)-AL1-MMAE
Anti-HER2 IgG1(GH2-61)-AL1
ERBB2
Monomethyl auristatin E
Undisclosed
[346]
IgG1 (GH2-61)-vc-MMAE
Anti-HER2 IgG1(GH2-61)
ERBB2
Monomethyl auristatin E
Mc-Val-Cit-PABC
[346]
IgG1 (GH2-75)-AL1-MMAE
Anti-HER2 IgG1(GH2-75)-AL1
ERBB2
Monomethyl auristatin E
Undisclosed
[346]
IgG1 (GH2-75)-vc-MMAE
Anti-HER2 IgG1(GH2-75)
ERBB2
Monomethyl auristatin E
Mc-Val-Cit-PABC
[346]
IgG1 (H32)-AL1-MMAE
Anti-HER2 IgG1(H32)-AL1
ERBB2
Monomethyl auristatin E
Undisclosed
[346]
IgG1 (H32)-vc-MMAE
Anti-HER2 IgG1(H32)
ERBB2
Monomethyl auristatin E
Mc-Val-Cit-PABC
[346]
IgG1 (trastuzumab)-AL1-MMAE
Trastuzumab-AL1
ERBB2
Monomethyl auristatin E
Undisclosed
[346]
IgG1 (trastuzumab)-vc-MMAE
Trastuzumab
ERBB2
Monomethyl auristatin E
Mc-Val-Cit-PABC
[346]
IgG78-DM1
Anti-CD248 mAb IgG78
CD248
Mertansine DM1
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
[347]
IGN-786
Anti-SAIL mAb
TSPO
Monomethyl auristatin F
Maleimido-caproyl
[348]
IIIA4-USAN
Anti-EPHA3 mAb IIIA4
EPHA3
Mertansine DM1
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
[349]
IMAB027-Val-Cit-MMAE
IMAB027
CLDN6
Monomethyl auristatin E
Mc-Val-Cit-PABC
[350]
IMAB362-MC-Val-Cit-PAB-MMAE
IMAB362
CLDN18.2
Monomethyl auristatin E
Mc-Val-Cit-PABC
[351]
IMAB362-Val-Cit-MMAE
IMAB362
CLDN18.2
Monomethyl auristatin E
Mc-Val-Cit-PABC
[352]
IMB-101
Undisclosed
CTSD
Mertansine DM1
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
[353]
IMB-102
Undisclosed
CTSD
Mertansine DM4
N-succinimidyl 4-(2-pyridyldithio) butanoate (SPDB)
[353]
Inebilizumab-2i
Inebilizumab
CD19
Monomethyl auristatin F
Inebilizumab-2i linker
[208]
Inebilizumab-3i
Inebilizumab
CD19
Monomethyl auristatin F
Inebilizumab-3i linker
[208]
Inebilizumab-4i
Inebilizumab
CD19
Monomethyl auristatin F
Inebilizumab-4i linker
[208]
Inebilizumab-6e
Inebilizumab
CD19
Monomethyl auristatin E
Inebilizumab-6e linker
[208]
Infliximab-Compound 17
Infliximab
TNF
Mertansine DM4
Infliximab-Compound 17 linker
[200]
Infliximab-Compound 25
Infliximab
TNF
Monomethyl auristatin E
Infliximab-Compound 25 linker
[200]
Infliximab-Compound 31
Infliximab
TNF
Auristatin 0101
Infliximab-Compound 31 linker
[200]
Infliximab-Compound 36
Infliximab
TNF
Monomethyl auristatin E
Infliximab-Compound 36 linker
[200]
Infliximab-Compound 55
Infliximab
TNF
Mertansine DM1
Infliximab-Compound 55 linker
[200]
Infliximab-Compound 59
Infliximab
TNF
Mertansine DM4
Infliximab-Compound 59 linker
[200]
Infliximab-Compound 64
Infliximab
TNF
Monomethyl auristatin E
Infliximab-Compound 64 linker
[200]
Infliximab-Compound 69
Infliximab
TNF
Monomethyl auristatin E
Infliximab-Compound 69 linker
[200]
Infliximab-Compound 75
Infliximab
TNF
Monomethyl auristatin E
Infliximab-Compound 75 linker
[200]
Infliximab-Compound 76
Infliximab
TNF
Monomethyl auristatin E
Infliximab-Compound 76 linker
[200]
Infliximab-Compound 77
Infliximab
TNF
Mertansine DM1
Infliximab-Compound 77 linker
[200]
Infliximab-Compound 78
Infliximab
TNF
Auristatin 0101
Infliximab-Compound 78 linker
[200]
Infliximab-Compound 79
Infliximab
TNF
Auristatin 0101
Infliximab-Compound 79 linker
[200]
Infliximab-Compound 80
Infliximab
TNF
Mertansine DM4
Infliximab-Compound 80 linker
[200]
Infliximab-Compound 9
Infliximab
TNF
Mertansine DM1
Infliximab-Compound 9 linker
[200]
Ipilimumab-Compound 17
Ipilimumab
CTLA4
Mertansine DM4
Ipilimumab-Compound 17 linker
[200]
Ipilimumab-Compound 25
Ipilimumab
CTLA4
Monomethyl auristatin E
Ipilimumab-Compound 25 linker
[200]
Ipilimumab-Compound 31
Ipilimumab
CTLA4
Auristatin 0101
Ipilimumab-Compound 31 linker
[200]
Ipilimumab-Compound 36
Ipilimumab
CTLA4
Monomethyl auristatin E
Ipilimumab-Compound 36 linker
[200]
Ipilimumab-Compound 55
Ipilimumab
CTLA4
Mertansine DM1
Ipilimumab-Compound 55 linker
[200]
Ipilimumab-Compound 59
Ipilimumab
CTLA4
Mertansine DM4
Ipilimumab-Compound 59 linker
[200]
Ipilimumab-Compound 64
Ipilimumab
CTLA4
Monomethyl auristatin E
Ipilimumab-Compound 64 linker
[200]
Ipilimumab-Compound 69
Ipilimumab
CTLA4
Monomethyl auristatin E
Ipilimumab-Compound 69 linker
[200]
Ipilimumab-Compound 75
Ipilimumab
CTLA4
Monomethyl auristatin E
Ipilimumab-Compound 75 linker
[200]
Ipilimumab-Compound 76
Ipilimumab
CTLA4
Monomethyl auristatin E
Ipilimumab-Compound 76 linker
[200]
Ipilimumab-Compound 77
Ipilimumab
CTLA4
Mertansine DM1
Ipilimumab-Compound 77 linker
[200]
Ipilimumab-Compound 78
Ipilimumab
CTLA4
Auristatin 0101
Ipilimumab-Compound 78 linker
[200]
Ipilimumab-Compound 79
Ipilimumab
CTLA4
Auristatin 0101
Ipilimumab-Compound 79 linker
[200]
Ipilimumab-Compound 80
Ipilimumab
CTLA4
Mertansine DM4
Ipilimumab-Compound 80 linker
[200]
Ipilimumab-Compound 9
Ipilimumab
CTLA4
Mertansine DM1
Ipilimumab-Compound 9 linker
[200]
ITcetuximab
Cetuximab
EGFR
Saporin
Undisclosed
[354]
JY207
Undisclosed
CD47; CD274
Monomethyl auristatin E
Undisclosed
[355]
LCB14-0645
Cetuximab (LV) G7-CVIM
EGFR
Monomethyl auristatin F
LCB14-0645 linker
[205]
LCB14-0648
Anti-CD19 mAb DI-B4
CD19
Monomethyl auristatin F
LCB14-0648 linker
[208]
LCB14-0663
Anti-CD19 mAb DI-B4
CD19
Monomethyl auristatin F
LCB14-0663 linker
[208]
LCB14-0664
Anti-CD19 mAb DI-B4
CD19
Monomethyl auristatin F
LCB14-0664 linker
[208]
LCB14-6e
Anti-CD19 mAb DI-B4
CD19
Monomethyl auristatin E
LCB14-6e linker
[208]
LCB-67
Undisclosed
DLK1
Monomethyl auristatin E
Undisclosed
[55]
LCB-97
Undisclosed
AFF4
Monomethyl auristatin E
Undisclosed
[356]
LCB-ADC1
Isoprenylated trastuzumab
ERBB2
Monomethyl auristatin F
Isoprene-PEG3-beta-Glu-PABC
[357]
LCB-ADC2
Isoprenylated trastuzumab
ERBB2
Monomethyl auristatin F
Isoprene-PEG3,3,3-beta-Glu-PABC
[357]
LCB-ADC3
Isoprenylated trastuzumab
ERBB2
Monomethyl auristatin F
Bridged PEG4-valine-alanine
[357]
lgG1-Mc-Val-Cit-MMAE
Anti-MET lgG1
MET
Monomethyl auristatin E
Mc-Val-Cit-PABC
[197]
LR004-Val-Cit-MMAE
LR004
EGFR
Monomethyl auristatin E
Mc-Val-Cit-PABC
[358]
LR-DM1
LR004
EGFR
Mertansine DM1
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
[359]
LRG1-ADC 5
Magacizumab
LRG1
Monomethyl auristatin E
Dipeptide-diBrPD (dibromopyridazinedione )
[360]
LSR-ADC
Anti-LSR mAb
LSR
Monomethyl auristatin E
Mc-Val-Cit-PABC
[361]
LY3343544
Emibetuzumab
MET
Monomethyl auristatin E
Undisclosed
[362]
M25ADCMMAE
Anti-ALPPL2 mAb M25
ALPG
Monomethyl auristatin E
Mc-Val-Cit-PABC
[363]
M25ADCMMAF
Anti-ALPPL2 mAb M25
ALPG
Monomethyl auristatin F
Mc-Val-Cit-PABC
[363]
M69-MMAE
Anti-Matriptase mAb M69
ST14
Monomethyl auristatin E
Mc-Val-Cit-PABC
[364]
M9346A Sulfo-SPDB DM4
Mirvetuximab
FOLR1
Mertansine DM4
Sulfo-SPDB
[339]
M9346A-4a-Cxxx-Mal-CX-DM1
Mirvetuximab (engineered cysteine LC-C205)
FOLR1
Mertansine DM1
Cxxx-Mal-CX
[365]
M9346A-4b-Cxxx-Mal-CX-DM1
Mirvetuximab (engineered cysteine LC-C400)
FOLR1
Mertansine DM1
Cxxx-Mal-CX
[365]
M9346A-4c-Cxxx-Mal-CX-DM1
Mirvetuximab (engineered cysteine HC-C118)
FOLR1
Mertansine DM1
Cxxx-Mal-CX
[365]
M9346A-4d-Cxxx-Mal-CX-DM1
Mirvetuximab (engineered cysteine HC-C239)
FOLR1
Mertansine DM1
Cxxx-Mal-CX
[365]
M9346A-CX-DM1
Mirvetuximab
FOLR1
Mertansine DM1
triglycyl peptide linker CX
[365]
M9346A-SMCC-DM1
Mirvetuximab
FOLR1
Mertansine DM1
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
[312]
M9346A-SPDB-DM4
Mirvetuximab
FOLR1
Mertansine DM4
N-succinimidyl 4-(2-pyridyldithio) butanoate (SPDB)
[312]
M9346A-SPP-DM1
Mirvetuximab
FOLR1
Mertansine DM1
N-succinimidyl 4-(2-pyridyldithio) pentanoate (SPP)
[312]
M9346A-sulfo-Mal-DM4
Mirvetuximab
FOLR1
Mertansine DM4
3-sulfo-Mal
[312]
MAb-DMBA-SIL-MMAE
Cetuximab
EGFR
Monomethyl auristatin E
DMBA-SIL
[211]
Magacizumab PD-MMAE ADC 5
Magacizumab
LRG1
Monomethyl auristatin E
Mepstra-PD-PEG3-Mal-Cit-PABC
[360]
MD1.22-DM1
mD1.22
env
Mertansine DM1
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
[298]
MDX-1342-2i
MDX-1342
CD19
Monomethyl auristatin F
MDX-1342-2i linker
[208]
MDX-1342-3i
MDX-1342
CD19
Monomethyl auristatin F
MDX-1342-3i linker
[208]
MDX-1342-4i
MDX-1342
CD19
Monomethyl auristatin F
MDX-1342-4i linker
[208]
MDX-1342-6e
MDX-1342
CD19
Monomethyl auristatin E
MDX-1342-6e linker
[208]
MDX-1435-2i
MDX-1435
CD19
Monomethyl auristatin F
MDX-1435-2i linker
[208]
MDX-1435-3i
MDX-1435
CD19
Monomethyl auristatin F
MDX-1435-3i linker
[208]
MDX-1435-4i
MDX-1435
CD19
Monomethyl auristatin F
MDX-1435-4i linker
[208]
MDX-1435-6e
MDX-1435
CD19
Monomethyl auristatin E
MDX-1435-6e linker
[208]
mesoADC
Anti-GSDME mAb
GSDME
Monomethyl auristatin E
Mc-Val-Cit-PABC
[366]
MET/MET-M114
Biparatopic METxMET Anti-ody
MET; MET
Maytansine derivative M24
Succinate-Val-Cit-PABC
[70]
MF-BTX-MMAE
Brentuximab
TNFRSF8
Monomethyl auristatin E
Dibromomethyl pyridine-Val-Cit-PABC
[367]
MF-TTZ-MMAE
Trastuzumab
ERBB2
Monomethyl auristatin E
Dibromomethyl pyridine-Val-Cit-PABC
[314]
MI-130004
Trastuzumab
ERBB2
PM050489
6-(2,5-dioxopyrrol-1-yl)-N-Propylhexanamide
[368]
MI-130110
Anti-CD13 TEA1/8 mAb
ANPEP
PM050489
6-(2,5-dioxopyrrol-1-yl)-N-Propylhexanamide
[369]
Mil40-12A
Mil40
ERBB2
Monomethyl auristatin E
Maleamic methyl ester-based linker 12A
[174]
Mil40-12C
Mil40
ERBB2
Monomethyl auristatin E
Maleamic methyl ester-based linker 12C
[174]
Mil40-15
Mil40
ERBB2
Monomethyl auristatin E
Mc-PABC
[293]
Mirvetuximab-SMCC-DM1
Mirvetuximab
FOLR1
Mertansine DM1
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
[339]
Mirvetuximab-SPDB-DM4
Mirvetuximab
FOLR1
Mertansine DM4
N-succinimidyl 4-(2-pyridyldithio) butanoate (SPDB)
[370]
Mirvetuximab-SPP-DM1
Mirvetuximab
FOLR1
Mertansine DM1
N-succinimidyl 4-(2-pyridyldithio) pentanoate (SPP)
[339]
MMAE.VC.SA.617
Undisclosed
FOLH1
Monomethyl auristatin E
Undisclosed
[371]
MMAE-9F7-F11 ADC
Anti-HER3 mAb 9F7-F11
ERBB3
Monomethyl auristatin E
Mc-Val-Cit-PABC
[372]
MMAE-IgG1 17
Anti-ENPP1 IgG1 17
ENPP1
Monomethyl auristatin E
Undisclosed
[373]
MMAE-IgG1 3G12
Anti-ENPP1 IgG1 3G12
ENPP1
Monomethyl auristatin E
Undisclosed
[373]
Monoclonal antibody HB2-saporin conjugate
Anti-CD7 mAb HB2
CD7
Saporin
Undisclosed
[374]
Mov19-3-sulfo-Mal-DM4
Mov19
FOLR1
Mertansine DM4
3-sulfo-Mal
[312]
Mov19-PEG4-Mal-DM1
Mov19
FOLR1
Mertansine DM1
PEG4-Mal
[312]
Mov19-PEG4-Mal-DM4
Mov19
FOLR1
Mertansine DM4
PEG4-Mal
[312]
Mov19-SIA-DM1
Mov19
FOLR1
Mertansine DM1
N-succinimidyl iodoacetate (SIA)
[312]
Mov19-SMCC-DM1
Mov19
FOLR1
Mertansine DM1
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
[312]
Mov19-SPDB-DM4
Mov19
FOLR1
Mertansine DM4
N-succinimidyl 4-(2-pyridyldithio) butanoate (SPDB)
[312]
Mov19-SPP-DM1
Mov19
FOLR1
Mertansine DM1
N-succinimidyl 4-(2-pyridyldithio) pentanoate (SPP)
[312]
Mov19-sulfo-SPDB-DM4
Mov19
FOLR1
Mertansine DM4
Sulfo-SPDB
[312]
MP-1959-ADC
Anti-LGALS3BP mAb 1959-sss
LGALS3BP
Maytansinoid
Undisclosed
[375]
MP-EV-20
EV20
ERBB3
Monomethyl auristatin F
Undisclosed
[376]
MP-HER3-ADC
Undisclosed
ERBB3
Monomethyl auristatin F
Undisclosed
[377]
MSLN ADC (Development Center for Biotechnology)
Undisclosed
MSLN
Monomethyl auristatin E
Undisclosed
[378]
MSLN MMAE
Undisclosed
MSLN
Monomethyl auristatin E
Undisclosed
[379]
MSLN-Mal-Caproyl-Val-Cit-PABC-Eribulin
Amatuximab
MSLN
Eribulin
Maleimide-Caproyl-Val-Cit-PABC
[313]
MSLN-Mal-Caproyl-Val-Cit-PABC-MMAE
Amatuximab
MSLN
Monomethyl auristatin E
Maleimide-Caproyl-Val-Cit-PABC
[313]
MSLN-Mal-Caproyl-Val-Cit-PABC-MMAF
Amatuximab
MSLN
Monomethyl auristatin F
Maleimide-Caproyl-Val-Cit-PABC
[313]
MSLN-Mal-PEG2-Ala-Ala-Asn-PABC-Eribulin
Amatuximab
MSLN
Eribulin
Mal-PEG2-Ala-Ala-Asn-PABC
[313]
MSLN-Mal-PEG2-Eribulin
Amatuximab
MSLN
Eribulin
Mal-PEG2
[313]
MSLN-Mal-PEG2-Val-Cit-PABC-Eribulin
Amatuximab
MSLN
Eribulin
Mal-PEG2-Val-Cit-PABC
[313]
MSLN-Mal-PEG4-Eribulin
Amatuximab
MSLN
Eribulin
Mal-PEG4
[313]
MSLN-Mal-PEG4-tria-PEG3-Dis-dim-PABC-Eribulin
Amatuximab
MSLN
Eribulin
Mal-PEG4-triazole-PEG3-Disulfidyl-dimethyl-PABC
[313]
MSLN-Mal-PEG4-tria-PEG3-Sulfo-Eribulin
Amatuximab
MSLN
Eribulin
Mal-PEG4-triazole-PEG3-Sulfonamide
[313]
MSLN-Mal-PEG8-Val-Cit-PABC-Eribulin
Amatuximab
MSLN
Eribulin
Mal-PEG8-Val-Cit-PABC
[313]
MSLN-Mal-PEG-Val-Cit-PABC-Cryptophycin
Amatuximab
MSLN
Cryptophycin
Mal-PEG-Val-Cit-PABC
[313]
MSLN-Suc/SPAAC-PEG2-Eribulin
Amatuximab
MSLN
Eribulin
Succinamide-SPAAC-PEG2
[313]
MSLN-Suc/SPAAC-PEG3-Dis-dim-PABC-Eribulin
Amatuximab
MSLN
Eribulin
Succinamide-SPAAC-PEG3-Disylfidyl-dimethyl-PABC
[313]
MSLN-Suc/SPAAC-PEG3-Sulfonamide-Eribulin
Amatuximab
MSLN
Eribulin
Succinamide-SPAAC-PEG3-Sulfonamide
[313]
MSLN-Suc/SPAAC-PEG4-Eribulin
Amatuximab
MSLN
Eribulin
Succinamide-SPAAC-PEG4
[313]
MSLN-Suc/SPAAC-PEG4-Val-Cit-PABC-Eribulin
Amatuximab
MSLN
Eribulin
Succinamide-SPAAC-PEG4-Val-Cit-PABC
[313]
MUC16-55 ADC
Anti-MUC16 mAb
MUC16
Maytansine derivative 55
Mal-EBE-Mal
[189]
MUC16-56 ADC
Anti-MUC16 mAb
MUC16
Maytansine derivative 56
Mal-EBE-Mal
[189]
muDS6-DM1
Anti-CA6 mAb muDS6
MUC1
Mertansine DM1
N-succinimidyl 4-(2-pyridyldithio) pentanoate (SPP)
[184]
muDS6-SSNPP-MM1-202
Anti-CA6 mAb muDS6
MUC1
Mertansine DM1
Sulfosuccinimidyl-N-succinimidyl-4-(5-nitro-2-pyridyldithio) pentanoate (SSNPP)
[184]
muFR1-13-3-sulfo-Mal-DM4
mu-FR1-13
FOLR1
Mertansine DM4
3-sulfo-Mal
[312]
muFR1-13-PEG4-Mal-DM1
mu-FR1-13
FOLR1
Mertansine DM1
PEG4-Mal
[312]
muFR1-13-PEG4-Mal-DM4
mu-FR1-13
FOLR1
Mertansine DM4
PEG4-Mal
[312]
muFR1-13-SIA-DM1
mu-FR1-13
FOLR1
Mertansine DM1
N-succinimidyl iodoacetate (SIA)
[312]
muFR1-13-SMCC-DM1
mu-FR1-13
FOLR1
Mertansine DM1
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
[312]
muFR1-13-SPDB-DM4
mu-FR1-13
FOLR1
Mertansine DM4
N-succinimidyl 4-(2-pyridyldithio) butanoate (SPDB)
[312]
muFR1-13-SPP-DM1
mu-FR1-13
FOLR1
Mertansine DM1
N-succinimidyl 4-(2-pyridyldithio) pentanoate (SPP)
[312]
muFR1-13-sulfo-SPDB-DM4
mu-FR1-13
FOLR1
Mertansine DM4
Sulfo-SPDB
[312]
muFR1-21-3-sulfo-Mal-DM4
mu-FR1-21
FOLR1
Mertansine DM4
3-sulfo-Mal
[312]
muFR1-21-PEG4-Mal-DM1
mu-FR1-21
FOLR1
Mertansine DM1
PEG4-Mal
[312]
muFR1-21-PEG4-Mal-DM4
mu-FR1-21
FOLR1
Mertansine DM4
PEG4-Mal
[312]
muFR1-21-SIA-DM1
mu-FR1-21
FOLR1
Mertansine DM1
N-succinimidyl iodoacetate (SIA)
[312]
muFR1-21-SMCC-DM1
mu-FR1-21
FOLR1
Mertansine DM1
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
[312]
muFR1-21-SPDB-DM4
mu-FR1-21
FOLR1
Mertansine DM4
N-succinimidyl 4-(2-pyridyldithio) butanoate (SPDB)
[312]
muFR1-21-SPP-DM1
mu-FR1-21
FOLR1
Mertansine DM1
N-succinimidyl 4-(2-pyridyldithio) pentanoate (SPP)
[312]
muFR1-21-sulfo-SPDB-DM4
mu-FR1-21
FOLR1
Mertansine DM4
Sulfo-SPDB
[312]
muFR1-22-3-sulfo-Mal-DM4
mu-FR1-22
FOLR1
Mertansine DM4
3-sulfo-Mal
[312]
muFR1-22-PEG4-Mal-DM1
mu-FR1-22
FOLR1
Mertansine DM1
PEG4-Mal
[312]
muFR1-22-PEG4-Mal-DM4
mu-FR1-22
FOLR1
Mertansine DM4
PEG4-Mal
[312]
muFR1-22-SIA-DM1
mu-FR1-22
FOLR1
Mertansine DM1
N-succinimidyl iodoacetate (SIA)
[312]
muFR1-22-SMCC-DM1
mu-FR1-22
FOLR1
Mertansine DM1
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
[312]
muFR1-22-SPDB-DM4
mu-FR1-22
FOLR1
Mertansine DM4
N-succinimidyl 4-(2-pyridyldithio) butanoate (SPDB)
[312]
muFR1-22-SPP-DM1
mu-FR1-22
FOLR1
Mertansine DM1
N-succinimidyl 4-(2-pyridyldithio) pentanoate (SPP)
[312]
muFR1-22-sulfo-SPDB-DM4
mu-FR1-22
FOLR1
Mertansine DM4
Sulfo-SPDB
[312]
muFR1-23-3-sulfo-Mal-DM4
mu-FR1-23
FOLR1
Mertansine DM4
3-sulfo-Mal
[312]
muFR1-23-PEG4-Mal-DM1
mu-FR1-23
FOLR1
Mertansine DM1
PEG4-Mal
[312]
muFR1-23-PEG4-Mal-DM4
mu-FR1-23
FOLR1
Mertansine DM4
PEG4-Mal
[312]
muFR1-23-SIA-DM1
mu-FR1-23
FOLR1
Mertansine DM1
N-succinimidyl iodoacetate (SIA)
[312]
muFR1-23-SMCC-DM1
mu-FR1-23
FOLR1
Mertansine DM1
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
[312]
muFR1-23-SPDB-DM4
mu-FR1-23
FOLR1
Mertansine DM4
N-succinimidyl 4-(2-pyridyldithio) butanoate (SPDB)
[312]
muFR1-23-SPP-DM1
mu-FR1-23
FOLR1
Mertansine DM1
N-succinimidyl 4-(2-pyridyldithio) pentanoate (SPP)
[312]
muFR1-23-sulfo-SPDB-DM4
mu-FR1-23
FOLR1
Mertansine DM4
Sulfo-SPDB
[312]
muFR1-9-3-sulfo-Mal-DM4
mu-FR1-9
FOLR1
Mertansine DM4
3-sulfo-Mal
[312]
muFR1-9-PEG4-Mal-DM1
mu-FR1-9
FOLR1
Mertansine DM1
PEG4-Mal
[312]
muFR1-9-PEG4-Mal-DM4
mu-FR1-9
FOLR1
Mertansine DM4
PEG4-Mal
[312]
muFR1-9-SIA-DM1
mu-FR1-9
FOLR1
Mertansine DM1
N-succinimidyl iodoacetate (SIA)
[312]
muFR1-9-SMCC-DM1
mu-FR1-9
FOLR1
Mertansine DM1
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
[312]
muFR1-9-SPDB-DM4
mu-FR1-9
FOLR1
Mertansine DM4
N-succinimidyl 4-(2-pyridyldithio) butanoate (SPDB)
[312]
muFR1-9-SPP-DM1
mu-FR1-9
FOLR1
Mertansine DM1
N-succinimidyl 4-(2-pyridyldithio) pentanoate (SPP)
[312]
muFR1-9-sulfo-SPDB-DM4
mu-FR1-9
FOLR1
Mertansine DM4
Sulfo-SPDB
[312]
MYK-3
BA03
EGFR
Monomethyl auristatin E
Mc-Val-Cit-PABC
[255]
N41mab-Val-Cit-MMAE
Undisclosed
NECTIN4
Monomethyl auristatin E
Mc-Val-Cit-PABC
[380]
nBT062-SMCC-DM1
Indatuximab
SDC1
Mertansine DM1
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
[258]
nBT062-SPDB-DM4
Indatuximab
SDC1
Mertansine DM4
N-succinimidyl 4-(2-pyridyldithio) butanoate (SPDB)
[258]
nBT062-SPP-DM1
Indatuximab
SDC1
Mertansine DM1
N-succinimidyl 4-(2-pyridyldithio) pentanoate (SPP)
[258]
NC-6201
NCAB001
EGFR
E7974
Undisclosed
[381]
NC-ADC
Trastuzumab
ERBB2
Monomethyl auristatin E
Divinylpyrimidine-PEG4
[270]
N-D2-1508
NIP228
EGFR; ERBB3
AZ-1508
Cysteine D2
[382]
N-D4-1508
NIP228
EGFR; ERBB3
AZ-1508
Cysteine D4
[382]
N-D6-1508
NIP228
EGFR; ERBB3
AZ-1508
Cysteine D6
[382]
N-D8-1508
NIP228
EGFR; ERBB3
AZ-1508
Cysteine D8
[382]
Nimotuzumab-Compound 17
Nimotuzumab
EGFR
Mertansine DM4
Nimotuzumab-Compound 17 linker
[200]
Nimotuzumab-Compound 25
Nimotuzumab
EGFR
Monomethyl auristatin E
Nimotuzumab-Compound 25 linker
[200]
Nimotuzumab-Compound 31
Nimotuzumab
EGFR
Auristatin 0101
Nimotuzumab-Compound 31 linker
[200]
Nimotuzumab-Compound 36
Nimotuzumab
EGFR
Monomethyl auristatin E
Nimotuzumab-Compound 36 linker
[200]
Nimotuzumab-Compound 55
Nimotuzumab
EGFR
Mertansine DM1
Nimotuzumab-Compound 55 linker
[200]
Nimotuzumab-Compound 59
Nimotuzumab
EGFR
Mertansine DM4
Nimotuzumab-Compound 59 linker
[200]
Nimotuzumab-Compound 64
Nimotuzumab
EGFR
Monomethyl auristatin E
Nimotuzumab-Compound 64 linker
[200]
Nimotuzumab-Compound 69
Nimotuzumab
EGFR
Monomethyl auristatin E
Nimotuzumab-Compound 69 linker
[200]
Nimotuzumab-Compound 75
Nimotuzumab
EGFR
Monomethyl auristatin E
Nimotuzumab-Compound 75 linker
[200]
Nimotuzumab-Compound 76
Nimotuzumab
EGFR
Monomethyl auristatin E
Nimotuzumab-Compound 76 linker
[200]
Nimotuzumab-Compound 77
Nimotuzumab
EGFR
Mertansine DM1
Nimotuzumab-Compound 77 linker
[200]
Nimotuzumab-Compound 78
Nimotuzumab
EGFR
Auristatin 0101
Nimotuzumab-Compound 78 linker
[200]
Nimotuzumab-Compound 79
Nimotuzumab
EGFR
Auristatin 0101
Nimotuzumab-Compound 79 linker
[200]
Nimotuzumab-Compound 80
Nimotuzumab
EGFR
Mertansine DM4
Nimotuzumab-Compound 80 linker
[200]
Nimotuzumab-Compound 9
Nimotuzumab
EGFR
Mertansine DM1
Nimotuzumab-Compound 9 linker
[200]
NN2101-DM1
NN2101
KIT
Mertansine DM1
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
[383]
NNAS-Mc-Val-Cit-PABC-MMAE
Anti-HER2 mAb NNAS
ERBB2
Monomethyl auristatin E
Mc-Val-Cit-PABC
[177]
NOV0712-DM4
Anti-CDH6 mAb NOV0712
CDH6
Mertansine DM4
Sulfo-SPDB
[324]
NS Cys-vc-MMAE
Undisclosed
EGFR
Monomethyl auristatin E
Mc-Val-Cit-PABC
[171]
OBA01
Zaptuzumab
TNFRSF10B
Monomethyl auristatin E
PY-MAA-Val-Cit-PABC
[384]
Oberotatug ravtansine
Undisclosed
LY75
Mertansine DM4
N-succinimidyl 4-(2-pyridyldithio) butanoate (SPDB)
[385]
Obexelimab-2i
Obexelimab
CD19
Monomethyl auristatin F
Obexelimab-2i linker
[208]
Obexelimab-3i
Obexelimab
CD19
Monomethyl auristatin F
Obexelimab-3i linker
[208]
Obexelimab-4i
Obexelimab
CD19
Monomethyl auristatin F
Obexelimab-4i linker
[208]
Obexelimab-6e
Obexelimab
CD19
Monomethyl auristatin E
Obexelimab-6e linker
[208]
OBI-998
OBI-898
Undisclosed
Monomethyl auristatin E
Maleimide and PEGylated cleavable linker
[386]
Ofatumumab-Compound 17
Ofatumumab
MS4A1
Mertansine DM4
Ofatumumab-Compound 17 linker
[200]
Ofatumumab-Compound 25
Ofatumumab
MS4A1
Monomethyl auristatin E
Ofatumumab-Compound 25 linker
[200]
Ofatumumab-Compound 31
Ofatumumab
MS4A1
Auristatin 0101
Ofatumumab-Compound 31 linker
[200]
Ofatumumab-Compound 36
Ofatumumab
MS4A1
Monomethyl auristatin E
Ofatumumab-Compound 36 linker
[200]
Ofatumumab-Compound 55
Ofatumumab
MS4A1
Mertansine DM1
Ofatumumab-Compound 55 linker
[200]
Ofatumumab-Compound 59
Ofatumumab
MS4A1
Mertansine DM4
Ofatumumab-Compound 59 linker
[200]
Ofatumumab-Compound 64
Ofatumumab
MS4A1
Monomethyl auristatin E
Ofatumumab-Compound 64 linker
[200]
Ofatumumab-Compound 69
Ofatumumab
MS4A1
Monomethyl auristatin E
Ofatumumab-Compound 69 linker
[200]
Ofatumumab-Compound 75
Ofatumumab
MS4A1
Monomethyl auristatin E
Ofatumumab-Compound 75 linker
[200]
Ofatumumab-Compound 76
Ofatumumab
MS4A1
Monomethyl auristatin E
Ofatumumab-Compound 76 linker
[200]
Ofatumumab-Compound 77
Ofatumumab
MS4A1
Mertansine DM1
Ofatumumab-Compound 77 linker
[200]
Ofatumumab-Compound 78
Ofatumumab
MS4A1
Auristatin 0101
Ofatumumab-Compound 78 linker
[200]
Ofatumumab-Compound 79
Ofatumumab
MS4A1
Auristatin 0101
Ofatumumab-Compound 79 linker
[200]
Ofatumumab-Compound 80
Ofatumumab
MS4A1
Mertansine DM4
Ofatumumab-Compound 80 linker
[200]
Ofatumumab-Compound 9
Ofatumumab
MS4A1
Mertansine DM1
Ofatumumab-Compound 9 linker
[200]
P38B-DM1
P38B
PDPN
Mertansine DM1
Azide-modified dibenzocyclooctyne(DBCO)-albumin(HAS)
[387]
Pab-001-MMAE
Pab-001
MUC1
Monomethyl auristatin E
Undisclosed
[388]
Panitumumab-Compound 17
Panitumumab
EGFR
Mertansine DM4
Panitumumab-Compound 17 linker
[200]
Panitumumab-Compound 25
Panitumumab
EGFR
Monomethyl auristatin E
Panitumumab-Compound 25 linker
[200]
Panitumumab-Compound 31
Panitumumab
EGFR
Auristatin 0101
Panitumumab-Compound 31 linker
[200]
Panitumumab-Compound 36
Panitumumab
EGFR
Monomethyl auristatin E
Panitumumab-Compound 36 linker
[200]
Panitumumab-Compound 55
Panitumumab
EGFR
Mertansine DM1
Panitumumab-Compound 55 linker
[200]
Panitumumab-Compound 59
Panitumumab
EGFR
Mertansine DM4
Panitumumab-Compound 59 linker
[200]
Panitumumab-Compound 64
Panitumumab
EGFR
Monomethyl auristatin E
Panitumumab-Compound 64 linker
[200]
Panitumumab-Compound 69
Panitumumab
EGFR
Monomethyl auristatin E
Panitumumab-Compound 69 linker
[200]
Panitumumab-Compound 75
Panitumumab
EGFR
Monomethyl auristatin E
Panitumumab-Compound 75 linker
[200]
Panitumumab-Compound 76
Panitumumab
EGFR
Monomethyl auristatin E
Panitumumab-Compound 76 linker
[200]
Panitumumab-Compound 77
Panitumumab
EGFR
Mertansine DM1
Panitumumab-Compound 77 linker
[200]
Panitumumab-Compound 78
Panitumumab
EGFR
Auristatin 0101
Panitumumab-Compound 78 linker
[200]
Panitumumab-Compound 79
Panitumumab
EGFR
Auristatin 0101
Panitumumab-Compound 79 linker
[200]
Panitumumab-Compound 80
Panitumumab
EGFR
Mertansine DM4
Panitumumab-Compound 80 linker
[200]
Panitumumab-Compound 9
Panitumumab
EGFR
Mertansine DM1
Panitumumab-Compound 9 linker
[200]
PCM5B14-MMAE
H5B14
MST1R
Monomethyl auristatin E
Mc-Val-Cit-PABC
[389]
PCM-MET01-MMAE
PCM-MET01
MET
Monomethyl auristatin E
Mc-Val-Cit-PABC
[390]
PD-L1 ADC 1
Avelumab
CD274
Monomethyl auristatin E
Mc-Val-Ala-PABC
[247]
PD-L1 ADC 2
Avelumab
CD274
Monomethyl auristatin E
Mc-Val-Cit-PABC
[247]
PD-L1 ADC 3
Atezolizumab
CD274
Monomethyl auristatin E
Mc-Val-Ala-PABC
[247]
PeptibodyC19-PEG4-Val-Cit-MMAE
Peptibody C19
FGFR1
Monomethyl auristatin E
Mc-Val-Cit-PABC
[391]
Pertuzumab-Compound 17
Pertuzumab
ERBB2
Mertansine DM4
Pertuzumab-Compound 17 linker
[200]
Pertuzumab-Compound 25
Pertuzumab
ERBB2
Monomethyl auristatin E
Pertuzumab-Compound 25 linker
[200]
Pertuzumab-Compound 31
Pertuzumab
ERBB2
Auristatin 0101
Pertuzumab-Compound 31 linker
[200]
Pertuzumab-Compound 36
Pertuzumab
ERBB2
Monomethyl auristatin E
Pertuzumab-Compound 36 linker
[200]
Pertuzumab-Compound 55
Pertuzumab
ERBB2
Mertansine DM1
Pertuzumab-Compound 55 linker
[200]
Pertuzumab-Compound 59
Pertuzumab
ERBB2
Mertansine DM4
Pertuzumab-Compound 59 linker
[200]
Pertuzumab-Compound 64
Pertuzumab
ERBB2
Monomethyl auristatin E
Pertuzumab-Compound 64 linker
[200]
Pertuzumab-Compound 69
Pertuzumab
ERBB2
Monomethyl auristatin E
Pertuzumab-Compound 69 linker
[200]
Pertuzumab-Compound 75
Pertuzumab
ERBB2
Monomethyl auristatin E
Pertuzumab-Compound 75 linker
[200]
Pertuzumab-Compound 76
Pertuzumab
ERBB2
Monomethyl auristatin E
Pertuzumab-Compound 76 linker
[200]
Pertuzumab-Compound 77
Pertuzumab
ERBB2
Mertansine DM1
Pertuzumab-Compound 77 linker
[200]
Pertuzumab-Compound 78
Pertuzumab
ERBB2
Auristatin 0101
Pertuzumab-Compound 78 linker
[200]
Pertuzumab-Compound 79
Pertuzumab
ERBB2
Auristatin 0101
Pertuzumab-Compound 79 linker
[200]
Pertuzumab-Compound 80
Pertuzumab
ERBB2
Mertansine DM4
Pertuzumab-Compound 80 linker
[200]
Pertuzumab-Compound 9
Pertuzumab
ERBB2
Mertansine DM1
Pertuzumab-Compound 9 linker
[200]
PODO447-ADC
PODO447
PODXL
Monomethyl auristatin E
Mc-Val-Cit-PABC
[392]
PRLR-16
Anti-PRLR mAb
PRLR
DM1 derivative 16
Mc-Val-Cit-PABC
[306]
Promiximab-MMAE
Promiximab
NCAM1
Monomethyl auristatin E
Mc-Val-Cit-PABC
[393]
PSMA-15
Anti-PSMA mAb
FOLH1
DM1 derivative 15
Mc-Val-Cit-PABC
[306]
PSMA-16
Anti-PSMA mAb
FOLH1
DM1 derivative 16
Mc-Val-Cit-PABC
[306]
PTM-001-ADC
Undisclosed
Undisclosed
Mertansine DM1
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
[394]
QD6/B09-AZ1508
QD6/B09
EGFR; MET
QD6/B09-AZ1508
QD6/B09-AZ1508
[395]
RAA22/B09-AZ1508
RAA22/B09
EGFR; MET
RAA22/B09-AZ1508
RAA22/B09-AZ1508
[395]
RBGO1-mcF
Anti-RAGE mAb RBGO1
AGER
Monomethyl auristatin F
Maleimido-caproyl
[396]
RC68-Mc-Val-Cit-PABC-MMAE
RC68
EGFR
Monomethyl auristatin E
Mc-Val-Cit-PABC
[397]
RC68-PY-Val-Cit-PABC-MMAE
RC68
EGFR
Monomethyl auristatin E
PY-VC-PABC
[397]
RC88-Mc-Val-Cit-PAB-MMAD
Anti-MSLN mAb
MSLN
Monomethyl auristatin D
Mc-Val-Cit-PABC
[398]
RC88-Mc-Val-Cit-PAB-MMAE
Anti-MSLN mAb
MSLN
Monomethyl auristatin E
Mc-Val-Cit-PABC
[398]
RC88-PY-MAA-Val-Cit-PAB-MMAD
Anti-MSLN mAb
MSLN
Monomethyl auristatin D
Mc-Val-Cit-PABC
[398]
RC88-PY-MAA-Val-Cit-PAB-MMAE
Anti-MSLN mAb
MSLN
Monomethyl auristatin E
Mc-Val-Cit-PABC
[398]
rcEDB-ADC
Reverse chimeric (rc) Anti-EDB-FN L19
FN1
Auristatin 0101
Mc-Val-Cit-PABC
[303]
REGN2878-DM1
REGN2878
PRLR
Mertansine DM1
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
[399]
RGCLN18.2-D07-Val-Cit-PAB-MMAE
RGCLN18.2
CLDN18.2
Monomethyl auristatin E
D07-Val-Cit-PABC
[351]
RGCLN18.2-MC-Val-Cit-PAB-MMAE
RGCLN18.2
CLDN18.2
Monomethyl auristatin E
Mc-Val-Cit-PABC
[351]
RGCLN18.2-PY-Val-Cit-PAB-MMAE
RGCLN18.2
CLDN18.2
Monomethyl auristatin E
PY-VC-PABC
[351]
Rituximab-Compound 17
Rituximab
MS4A1
Mertansine DM4
Rituximab-Compound 17 linker
[200]
Rituximab-Compound 25
Rituximab
MS4A1
Monomethyl auristatin E
Rituximab-Compound 25 linker
[200]
Rituximab-Compound 31
Rituximab
MS4A1
Auristatin 0101
Rituximab-Compound 31 linker
[200]
Rituximab-Compound 36
Rituximab
MS4A1
Monomethyl auristatin E
Rituximab-Compound 36 linker
[200]
Rituximab-Compound 55
Rituximab
MS4A1
Mertansine DM1
Rituximab-Compound 55 linker
[200]
Rituximab-Compound 59
Rituximab
MS4A1
Mertansine DM4
Rituximab-Compound 59 linker
[200]
Rituximab-Compound 64
Rituximab
MS4A1
Monomethyl auristatin E
Rituximab-Compound 64 linker
[200]
Rituximab-Compound 69
Rituximab
MS4A1
Monomethyl auristatin E
Rituximab-Compound 69 linker
[200]
Rituximab-Compound 75
Rituximab
MS4A1
Monomethyl auristatin E
Rituximab-Compound 75 linker
[200]
Rituximab-Compound 76
Rituximab
MS4A1
Monomethyl auristatin E
Rituximab-Compound 76 linker
[200]
Rituximab-Compound 77
Rituximab
MS4A1
Mertansine DM1
Rituximab-Compound 77 linker
[200]
Rituximab-Compound 78
Rituximab
MS4A1
Auristatin 0101
Rituximab-Compound 78 linker
[200]
Rituximab-Compound 79
Rituximab
MS4A1
Auristatin 0101
Rituximab-Compound 79 linker
[200]
Rituximab-Compound 80
Rituximab
MS4A1
Mertansine DM4
Rituximab-Compound 80 linker
[200]
Rituximab-Compound 9
Rituximab
MS4A1
Mertansine DM1
Rituximab-Compound 9 linker
[200]
RN765C
EGFR Ab-L
EGFR
Auristatin 0101
AcLys-Val-Cit-PABC
[400]
RN927C
Humanized Anti-Trop-2 hIgG1 Anti-ody
TACSTD2
Auristatin 0101
AcLys-Val-Cit-PABC
[401]
S3F-CL-MMAE
Anti-sTn mAb S3F
Undisclosed
Monomethyl auristatin E
Mc-Val-Cit-PABC
[402]
S7 ADC
9G8-7D12-Fc
EGFR
Monomethyl auristatin E
Mc-Val-Cit-PABC
[403]
S7-E430G ADC
9G8-7D12-Fc with E430G
EGFR
Monomethyl auristatin E
Mc-Val-Cit-PABC
[403]
Sacituzumab-Compound 17
Sacituzumab
TACSTD2
Mertansine DM4
Sacituzumab-Compound 17 linker
[200]
Sacituzumab-Compound 25
Sacituzumab
TACSTD2
Monomethyl auristatin E
Sacituzumab-Compound 25 linker
[200]
Sacituzumab-Compound 31
Sacituzumab
TACSTD2
Auristatin 0101
Sacituzumab-Compound 31 linker
[200]
Sacituzumab-Compound 36
Sacituzumab
TACSTD2
Monomethyl auristatin E
Sacituzumab-Compound 36 linker
[200]
Sacituzumab-Compound 55
Sacituzumab
TACSTD2
Mertansine DM1
Sacituzumab-Compound 55 linker
[200]
Sacituzumab-Compound 59
Sacituzumab
TACSTD2
Mertansine DM4
Sacituzumab-Compound 59 linker
[200]
Sacituzumab-Compound 64
Sacituzumab
TACSTD2
Monomethyl auristatin E
Sacituzumab-Compound 64 linker
[200]
Sacituzumab-Compound 69
Sacituzumab
TACSTD2
Monomethyl auristatin E
Sacituzumab-Compound 69 linker
[200]
Sacituzumab-Compound 75
Sacituzumab
TACSTD2
Monomethyl auristatin E
Sacituzumab-Compound 75 linker
[200]
Sacituzumab-Compound 76
Sacituzumab
TACSTD2
Monomethyl auristatin E
Sacituzumab-Compound 76 linker
[200]
Sacituzumab-Compound 77
Sacituzumab
TACSTD2
Mertansine DM1
Sacituzumab-Compound 77 linker
[200]
Sacituzumab-Compound 78
Sacituzumab
TACSTD2
Auristatin 0101
Sacituzumab-Compound 78 linker
[200]
Sacituzumab-Compound 79
Sacituzumab
TACSTD2
Auristatin 0101
Sacituzumab-Compound 79 linker
[200]
Sacituzumab-Compound 80
Sacituzumab
TACSTD2
Mertansine DM4
Sacituzumab-Compound 80 linker
[200]
Sacituzumab-Compound 9
Sacituzumab
TACSTD2
Mertansine DM1
Sacituzumab-Compound 9 linker
[200]
Sal5-DM4
Sal5
EGFR; ERBB3
Mertansine DM4
N-succinimidyl 4-(2-pyridyldithio) butanoate (SPDB)
[294]
Sal5-MMAE
Sal5
EGFR; ERBB3
Monomethyl auristatin E
Mc-Val-Cit-PABC
[294]
SC16.101-DL1
SC16.101
DLL3
SG2000 derivative PBD 1
Mal-PEG8-Val-Ala
[404]
SC16.103-DL1
SC16.103
DLL3
SG2000 derivative PBD 1
Mal-PEG8-Val-Ala
[404]
SC16.104-DL1
SC16.104
DLL3
SG2000 derivative PBD 1
Mal-PEG8-Val-Ala
[404]
SC16.105-DL1
SC16.105
DLL3
SG2000 derivative PBD 1
Mal-PEG8-Val-Ala
[404]
SC16.106-DL1
SC16.106
DLL3
SG2000 derivative PBD 1
Mal-PEG8-Val-Ala
[404]
SC16.107-DL1
SC16.107
DLL3
SG2000 derivative PBD 1
Mal-PEG8-Val-Ala
[404]
SC16.108-DL1
SC16.108
DLL3
SG2000 derivative PBD 1
Mal-PEG8-Val-Ala
[404]
SC16.109-DL1
SC16.109
DLL3
SG2000 derivative PBD 1
Mal-PEG8-Val-Ala
[404]
SC16.10-DL1
SC16.10
DLL3
SG2000 derivative PBD 1
Mal-PEG8-Val-Ala
[404]
SC16.110-DL1
SC16.110
DLL3
SG2000 derivative PBD 1
Mal-PEG8-Val-Ala
[404]
SC16.111-DL1
SC16.111
DLL3
SG2000 derivative PBD 1
Mal-PEG8-Val-Ala
[404]
SC16.113-DL1
SC16.113
DLL3
SG2000 derivative PBD 1
Mal-PEG8-Val-Ala
[404]
SC16.114-DL1
SC16.114
DLL3
SG2000 derivative PBD 1
Mal-PEG8-Val-Ala
[404]
SC16.115-DL1
SC16.115
DLL3
SG2000 derivative PBD 1
Mal-PEG8-Val-Ala
[404]
SC16.116-DL1
SC16.116
DLL3
SG2000 derivative PBD 1
Mal-PEG8-Val-Ala
[404]
SC16.117-DL1
SC16.117
DLL3
SG2000 derivative PBD 1
Mal-PEG8-Val-Ala
[404]
SC16.118-DL1
SC16.118
DLL3
SG2000 derivative PBD 1
Mal-PEG8-Val-Ala
[404]
SC16.11-DL1
SC16.11
DLL3
SG2000 derivative PBD 1
Mal-PEG8-Val-Ala
[404]
SC16.120-DL1
SC16.120
DLL3
SG2000 derivative PBD 1
Mal-PEG8-Val-Ala
[404]
SC16.121-DL1
SC16.121
DLL3
SG2000 derivative PBD 1
Mal-PEG8-Val-Ala
[404]
SC16.122-DL1
SC16.122
DLL3
SG2000 derivative PBD 1
Mal-PEG8-Val-Ala
[404]
SC16.123-DL1
SC16.123
DLL3
SG2000 derivative PBD 1
Mal-PEG8-Val-Ala
[404]
SC16.124-DL1
SC16.124
DLL3
SG2000 derivative PBD 1
Mal-PEG8-Val-Ala
[404]
SC16.125-DL1
SC16.125
DLL3
SG2000 derivative PBD 1
Mal-PEG8-Val-Ala
[404]
SC16.126-DL1
SC16.126
DLL3
SG2000 derivative PBD 1
Mal-PEG8-Val-Ala
[404]
SC16.129-DL1
SC16.129
DLL3
SG2000 derivative PBD 1
Mal-PEG8-Val-Ala
[404]
SC16.130-DL1
SC16.130
DLL3
SG2000 derivative PBD 1
Mal-PEG8-Val-Ala
[404]
SC16.131-DL1
SC16.131
DLL3
SG2000 derivative PBD 1
Mal-PEG8-Val-Ala
[404]
SC16.132-DL1
SC16.132
DLL3
SG2000 derivative PBD 1
Mal-PEG8-Val-Ala
[404]
SC16.133-DL1
SC16.133
DLL3
SG2000 derivative PBD 1
Mal-PEG8-Val-Ala
[404]
SC16.134-DL1
SC16.134
DLL3
SG2000 derivative PBD 1
Mal-PEG8-Val-Ala
[404]
SC16.135-DL1
SC16.135
DLL3
SG2000 derivative PBD 1
Mal-PEG8-Val-Ala
[404]
SC16.136-DL1
SC16.136
DLL3
SG2000 derivative PBD 1
Mal-PEG8-Val-Ala
[404]
SC16.137-DL1
SC16.137
DLL3
SG2000 derivative PBD 1
Mal-PEG8-Val-Ala
[404]
SC16.138-DL1
SC16.138
DLL3
SG2000 derivative PBD 1
Mal-PEG8-Val-Ala
[404]
SC16.139-DL1
SC16.139
DLL3
SG2000 derivative PBD 1
Mal-PEG8-Val-Ala
[404]
SC16.13-DL1
SC16.13
DLL3
SG2000 derivative PBD 1
Mal-PEG8-Val-Ala
[404]
SC16.140-DL1
SC16.140
DLL3
SG2000 derivative PBD 1
Mal-PEG8-Val-Ala
[404]
SC16.141-DL1
SC16.141
DLL3
SG2000 derivative PBD 1
Mal-PEG8-Val-Ala
[404]
SC16.142-DL1
SC16.142
DLL3
SG2000 derivative PBD 1
Mal-PEG8-Val-Ala
[404]
SC16.143-DL1
SC16.143
DLL3
SG2000 derivative PBD 1
Mal-PEG8-Val-Ala
[404]
SC16.144-DL1
SC16.144
DLL3
SG2000 derivative PBD 1
Mal-PEG8-Val-Ala
[404]
SC16.147-DL1
SC16.147
DLL3
SG2000 derivative PBD 1
Mal-PEG8-Val-Ala
[404]
SC16.148-DL1
SC16.148
DLL3
SG2000 derivative PBD 1
Mal-PEG8-Val-Ala
[404]
SC16.149-DL1
SC16.149
DLL3
SG2000 derivative PBD 1
Mal-PEG8-Val-Ala
[404]
SC16.150-DL1
SC16.150
DLL3
SG2000 derivative PBD 1
Mal-PEG8-Val-Ala
[404]
SC16.15-DL1
SC16.15
DLL3
SG2000 derivative PBD 1
Mal-PEG8-Val-Ala
[404]
SC16.18-DL1
SC16.18
DLL3
SG2000 derivative PBD 1
Mal-PEG8-Val-Ala
[404]
SC16.19-DL1
SC16.19
DLL3
SG2000 derivative PBD 1
Mal-PEG8-Val-Ala
[404]
SC16.20-DL1
SC16.20
DLL3
SG2000 derivative PBD 1
Mal-PEG8-Val-Ala
[404]
SC16.21-DL1
SC16.21
DLL3
SG2000 derivative PBD 1
Mal-PEG8-Val-Ala
[404]
SC16.22-DL1
SC16.22
DLL3
SG2000 derivative PBD 1
Mal-PEG8-Val-Ala
[404]
SC16.23-DL1
SC16.23
DLL3
SG2000 derivative PBD 1
Mal-PEG8-Val-Ala
[404]
SC16.25-DL1
SC16.25
DLL3
SG2000 derivative PBD 1
Mal-PEG8-Val-Ala
[404]
SC16.26-DL1
SC16.26
DLL3
SG2000 derivative PBD 1
Mal-PEG8-Val-Ala
[404]
SC16.29-DL1
SC16.29
DLL3
SG2000 derivative PBD 1
Mal-PEG8-Val-Ala
[404]
SC16.30-DL1
SC16.30
DLL3
SG2000 derivative PBD 1
Mal-PEG8-Val-Ala
[404]
SC16.31-DL1
SC16.31
DLL3
SG2000 derivative PBD 1
Mal-PEG8-Val-Ala
[404]
SC16.34-DL1
SC16.34
DLL3
SG2000 derivative PBD 1
Mal-PEG8-Val-Ala
[404]
SC16.35-DL1
SC16.35
DLL3
SG2000 derivative PBD 1
Mal-PEG8-Val-Ala
[404]
SC16.36-DL1
SC16.36
DLL3
SG2000 derivative PBD 1
Mal-PEG8-Val-Ala
[404]
SC16.38-DL1
SC16.38
DLL3
SG2000 derivative PBD 1
Mal-PEG8-Val-Ala
[404]
SC16.3-DL1
SC16.3
DLL3
SG2000 derivative PBD 1
Mal-PEG8-Val-Ala
[404]
SC16.41-DL1
SC16.41
DLL3
SG2000 derivative PBD 1
Mal-PEG8-Val-Ala
[404]
SC16.42-DL1
SC16.42
DLL3
SG2000 derivative PBD 1
Mal-PEG8-Val-Ala
[404]
SC16.45-DL1
SC16.45
DLL3
SG2000 derivative PBD 1
Mal-PEG8-Val-Ala
[404]
SC16.47-DL1
SC16.47
DLL3
SG2000 derivative PBD 1
Mal-PEG8-Val-Ala
[404]
SC16.49-DL1
SC16.49
DLL3
SG2000 derivative PBD 1
Mal-PEG8-Val-Ala
[404]
SC16.4-DL1
SC16.4
DLL3
SG2000 derivative PBD 1
Mal-PEG8-Val-Ala
[404]
SC16.50-DL1
SC16.50
DLL3
SG2000 derivative PBD 1
Mal-PEG8-Val-Ala
[404]
SC16.52-DL1
SC16.52
DLL3
SG2000 derivative PBD 1
Mal-PEG8-Val-Ala
[404]
SC16.55-DL1
SC16.55
DLL3
SG2000 derivative PBD 1
Mal-PEG8-Val-Ala
[404]
SC16.56-DL1
SC16.56
DLL3
SG2000 derivative PBD 1
Mal-PEG8-Val-Ala
[404]
SC16.57-DL1
SC16.57
DLL3
SG2000 derivative PBD 1
Mal-PEG8-Val-Ala
[404]
SC16.58-DL1
SC16.58
DLL3
SG2000 derivative PBD 1
Mal-PEG8-Val-Ala
[404]
SC16.5-DL1
SC16.5
DLL3
SG2000 derivative PBD 1
Mal-PEG8-Val-Ala
[404]
SC16.61-DL1
SC16.61
DLL3
SG2000 derivative PBD 1
Mal-PEG8-Val-Ala
[404]
SC16.62-DL1
SC16.62
DLL3
SG2000 derivative PBD 1
Mal-PEG8-Val-Ala
[404]
SC16.63-DL1
SC16.63
DLL3
SG2000 derivative PBD 1
Mal-PEG8-Val-Ala
[404]
SC16.65-DL1
SC16.65
DLL3
SG2000 derivative PBD 1
Mal-PEG8-Val-Ala
[404]
SC16.67-DL1
SC16.67
DLL3
SG2000 derivative PBD 1
Mal-PEG8-Val-Ala
[404]
SC16.68-DL1
SC16.68
DLL3
SG2000 derivative PBD 1
Mal-PEG8-Val-Ala
[404]
SC16.72-DL1
SC16.72
DLL3
SG2000 derivative PBD 1
Mal-PEG8-Val-Ala
[404]
SC16.73-DL1
SC16.73
DLL3
SG2000 derivative PBD 1
Mal-PEG8-Val-Ala
[404]
SC16.78-DL1
SC16.78
DLL3
SG2000 derivative PBD 1
Mal-PEG8-Val-Ala
[404]
SC16.79-DL1
SC16.79
DLL3
SG2000 derivative PBD 1
Mal-PEG8-Val-Ala
[404]
SC16.7-DL1
SC16.7
DLL3
SG2000 derivative PBD 1
Mal-PEG8-Val-Ala
[404]
SC16.80-DL1
SC16.80
DLL3
SG2000 derivative PBD 1
Mal-PEG8-Val-Ala
[404]
SC16.81-DL1
SC16.81
DLL3
SG2000 derivative PBD 1
Mal-PEG8-Val-Ala
[404]
SC16.84-DL1
SC16.84
DLL3
SG2000 derivative PBD 1
Mal-PEG8-Val-Ala
[404]
SC16.88-DL1
SC16.88
DLL3
SG2000 derivative PBD 1
Mal-PEG8-Val-Ala
[404]
SC16.8-DL1
SC16.8
DLL3
SG2000 derivative PBD 1
Mal-PEG8-Val-Ala
[404]
scFvF7-Fc-vcMMAE
Anti-FGFR2 scFv ECD_FGFR2
FGFR2
Monomethyl auristatin E
Mc-Val-Cit-PABC
[405]
ScFvGPIIb/IIIa-MMAE
Anti-ITGA2B scFv
ITGB3
Monomethyl auristatin E
Mc-Val-Cit-PABC
[406]
Septuximab vedotin
Septuximab
FZD7
Monomethyl auristatin E
Mc-Val-Cit-PABC
[311]
SG1-Val-Cit-MMAF8
SG1
TNFRSF17
Monomethyl auristatin F
Mc-Val-Cit-PABC
[407]
SG2-Val-Cit-MMAF8
SG2
TNFRSF17
Monomethyl auristatin F
Mc-Val-Cit-PABC
[407]
SG3-Val-Cit-MMAF8
SG3
TNFRSF17
Monomethyl auristatin F
Mc-Val-Cit-PABC
[407]
SHR-A1307
Anti-EGFR mAb hR3-YTE
EGFR
SHR152852
L2-MC
[408]
SNS-622-DM1
SNS-622
ASPH
Mertansine DM1
Maleimido-caproyl
[409]
SNS-622-MMAE
SNS-622
ASPH
Monomethyl auristatin E
Mc-Val-Cit-PABC
[409]
SS1-Val-Cit-MMAE
Anti-MSLN IgG1-SS1
MSLN
Monomethyl auristatin E
Mc-Val-Cit-PABC
[210]
SSaPB-DM1
SSaPB
MUC1
Mertansine DM1
N-succinimidyl 4-(2-pyridyldithio) pentanoate (SPP)
[184]
ST1
Undisclosed
Undisclosed
Monomethyl auristatin E
Undisclosed
[410]
Stable nBT062-DM4
Indatuximab (S228P + R409K)
SDC1
Mertansine DM4
N-succinimidyl 4-(2-pyridyldithio) butanoate (SPDB)
[263]
Tafasitamab-2i
Tafasitamab
CD19
Monomethyl auristatin F
Tafasitamab-2i linker
[208]
Tafasitamab-3i
Tafasitamab
CD19
Monomethyl auristatin F
Tafasitamab-3i linker
[208]
Tafasitamab-4i
Tafasitamab
CD19
Monomethyl auristatin F
Tafasitamab-4i linker
[208]
Tafasitamab-6e
Tafasitamab
CD19
Monomethyl auristatin E
Tafasitamab-6e linker
[208]
T-C-F (DAR 3.7)
Trastuzumab
ERBB2
Monomethyl auristatin F
Maleimido-caproyl
[411]
T-CpHK-Mal-ADC
Trastuzumab-CpHK
ERBB2
Monomethyl auristatin E
Mc-Val-Cit-PABC
[412]
T-CpHK-Tet-ADC
Trastuzumab-CpHK
ERBB2
Monomethyl auristatin E
Tetrazine-PEG5-Val-Ala-PABC
[412]
T-D2-1508
Trastuzumab
ERBB2
AZ-1508
Cysteine D2
[382]
T-D4-1508
Trastuzumab
ERBB2
AZ-1508
Cysteine D4
[382]
T-D6-1508
Trastuzumab
ERBB2
AZ-1508
Cysteine D6
[382]
T-D8-1508
Trastuzumab
ERBB2
AZ-1508
Cysteine D8
[382]
T-DM1-2.6
Trastuzumab
ERBB2
Mertansine DM1
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
[334]
T-DM1-IR700
Trastuzumab
ERBB2
Mertansine DM1 plus IRDye700DX
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
[413]
TEM1 Clone 187 A114N-Mc-Val-Cit-PABC-MMAE
Anti-TEM1 mAb Clone 187 A114N
CD248
Monomethyl auristatin E
Mc-Val-Cit-PABC
[177]
TEM1 Clone 187 WT-Mc-Val-Cit-PABC-MMAE
Anti-TEM1 mAb Clone 187 WT
CD248
Monomethyl auristatin E
Mc-Val-Cit-PABC
[177]
T-FcBP-DM1
Trastuzumab
ERBB2
Mertansine DM1
N-terminal norbornene group pFcBP linker
[414]
T-Fc-Val-Cit-MMAE
Human Anti-FGFR1 Fc
FGFR1
Monomethyl auristatin E
Mc-Val-Cit-PABC
[415]
TF-mAb-DM1
TF-mAb-SC1
F3
Mertansine DM1
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
[416]
TF-mAb-H29-DM1
TF-mAb-H29
F3
Mertansine DM1
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
[416]
TF-mAb-H29-MMAE
TF-mAb-H29
F3
Monomethyl auristatin E
Mc-Val-Cit-PABC
[416]
TF-mAb-H30-DM1
TF-mAb-H30
F3
Mertansine DM1
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
[416]
TF-mAb-H30-MMAE
TF-mAb-H30
F3
Monomethyl auristatin E
Mc-Val-Cit-PABC
[416]
TF-mAb-H31-DM1
TF-mAb-H31
F3
Mertansine DM1
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
[416]
TF-mAb-H31-MMAE
TF-mAb-H31
F3
Monomethyl auristatin E
Mc-Val-Cit-PABC
[416]
TF-mAb-H32-DM1
TF-mAb-H32
F3
Mertansine DM1
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
[416]
TF-mAb-H32-MMAE
TF-mAb-H32
F3
Monomethyl auristatin E
Mc-Val-Cit-PABC
[416]
TF-mAb-H33-DM1
TF-mAb-H33
F3
Mertansine DM1
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
[416]
TF-mAb-H33-MMAE
TF-mAb-H33
F3
Monomethyl auristatin E
Mc-Val-Cit-PABC
[416]
TF-mAb-H34-DM1
TF-mAb-H34
F3
Mertansine DM1
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
[416]
TF-mAb-H34-MMAE
TF-mAb-H34
F3
Monomethyl auristatin E
Mc-Val-Cit-PABC
[416]
TF-mAb-H35-DM1
TF-mAb-H35
F3
Mertansine DM1
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
[416]
TF-mAb-H35-MMAE
TF-mAb-H35
F3
Monomethyl auristatin E
Mc-Val-Cit-PABC
[416]
TF-mAb-H36-DM1
TF-mAb-H36
F3
Mertansine DM1
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
[416]
TF-mAb-H36-MMAE
TF-mAb-H36
F3
Monomethyl auristatin E
Mc-Val-Cit-PABC
[416]
TF-mAb-H37-DM1
TF-mAb-H37
F3
Mertansine DM1
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
[416]
TF-mAb-H37-MMAE
TF-mAb-H37
F3
Monomethyl auristatin E
Mc-Val-Cit-PABC
[416]
TF-mAb-H38-DM1
TF-mAb-H38
F3
Mertansine DM1
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
[416]
TF-mAb-H38-MMAE
TF-mAb-H38
F3
Monomethyl auristatin E
Mc-Val-Cit-PABC
[416]
TF-mAb-H39-DM1
TF-mAb-H39
F3
Mertansine DM1
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
[416]
TF-mAb-H39-MMAE
TF-mAb-H39
F3
Monomethyl auristatin E
Mc-Val-Cit-PABC
[416]
TF-mAb-H40-DM1
TF-mAb-H40
F3
Mertansine DM1
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
[416]
TF-mAb-H40-MMAE
TF-mAb-H40
F3
Monomethyl auristatin E
Mc-Val-Cit-PABC
[416]
TF-mAb-H41-DM1
TF-mAb-H41
F3
Mertansine DM1
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
[416]
TF-mAb-H41-MMAE
TF-mAb-H41
F3
Monomethyl auristatin E
Mc-Val-Cit-PABC
[416]
TF-mAb-H42-DM1
TF-mAb-H42
F3
Mertansine DM1
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
[416]
TF-mAb-H42-MMAE
TF-mAb-H42
F3
Monomethyl auristatin E
Mc-Val-Cit-PABC
[416]
TF-mAb-H43-DM1
TF-mAb-H43
F3
Mertansine DM1
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
[416]
TF-mAb-H43-MMAE
TF-mAb-H43
F3
Monomethyl auristatin E
Mc-Val-Cit-PABC
[416]
TF-mAb-H44-DM1
TF-mAb-H44
F3
Mertansine DM1
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
[416]
TF-mAb-H44-MMAE
TF-mAb-H44
F3
Monomethyl auristatin E
Mc-Val-Cit-PABC
[416]
TF-mAb-H45-DM1
TF-mAb-H45
F3
Mertansine DM1
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
[416]
TF-mAb-H45-MMAE
TF-mAb-H45
F3
Monomethyl auristatin E
Mc-Val-Cit-PABC
[416]
TF-mAb-H46-DM1
TF-mAb-H46
F3
Mertansine DM1
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
[416]
TF-mAb-H46-MMAE
TF-mAb-H46
F3
Monomethyl auristatin E
Mc-Val-Cit-PABC
[416]
TF-mAb-H47-DM1
TF-mAb-H47
F3
Mertansine DM1
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
[416]
TF-mAb-H47-MMAE
TF-mAb-H47
F3
Monomethyl auristatin E
Mc-Val-Cit-PABC
[416]
TF-mAb-H48-DM1
TF-mAb-H48
F3
Mertansine DM1
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
[416]
TF-mAb-H48-MMAE
TF-mAb-H48
F3
Monomethyl auristatin E
Mc-Val-Cit-PABC
[416]
TF-mAb-MMAE
TF-mAb-SC1
F3
Monomethyl auristatin E
Mc-Val-Cit-PABC
[416]
TH2-mpeoDM1
Anti-DLL4 mAb TH2 (A121C)
DLL4
Mertansine DM1
BIMPRO
[328]
Thio-3A5 (A121C)-BMPEO-DM1
Thio-3A5 (A121C)
MUC16
Maytansinoid DM1
Thio-3A5 (A121C)-BMPEO-DM1 linker
[187]
Thio-Tmab-BMPEO-DM1
Thio-Tmab
ERBB2
Maytansinoid DM1
Thio-Tmab-BMPEO-DM1 linker
[187]
Thio-Tr (A121C)-BMPEO-DM1
Thio-Tr (A121C)
ERBB2
Maytansinoid DM1
Thio-Tr (A121C)-BMPEO-DM1 linker
[187]
THL4-mpeoDM1
Anti-DLL4 mAb THL4 (V207C, A121C)
DLL4
Mertansine DM1
BIMPRO
[328]
THL4-vcMMAE
Anti-DLL4 mAb THL4 (V207C, A121C)
DLL4
Monomethyl auristatin E
Mc-Val-Cit-PABC
[328]
T-K-F (DAR 3.9)
Trastuzumab
ERBB2
Monomethyl auristatin F
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
[411]
TL2-mpeoDM1
Anti-DLL4 mAb TL2 (V207C)
DLL4
Mertansine DM1
BIMPRO
[328]
Tmab-SPDP-DM1
Trastuzumab
ERBB2
Mertansine DM1
N-succinimidyl 4-(2-pyridyldithio) butanoate (SPDB)
[417]
Tmab-SPP-DM1
Trastuzumab
ERBB2
Mertansine DM1
N-succinimidyl 4-(2-pyridyldithio) pentanoate (SPP)
[417]
Tmab-SSNPP-DM3
Trastuzumab
ERBB2
Maytansinoid DM3
Sulfosuccinimidyl-N-succinimidyl-4-(5-nitro-2-pyridyldithio) pentanoate (SSNPP)
[417]
Tmab-SSNPP-DM4
Trastuzumab
ERBB2
Mertansine DM4
Sulfosuccinimidyl-N-succinimidyl-4-(5-nitro-2-pyridyldithio) pentanoate (SSNPP)
[417]
T-N-F (DAR 1.6)
Trastuzumab
ERBB2
Aldehyde-tagged MMAF
Undisclosed
[411]
T-N-F (DAR 3.2)
Trastuzumab
ERBB2
Aldehyde-tagged MMAF
Undisclosed
[411]
Tositumomab-Compound 17
Tositumomab
MS4A1
Mertansine DM4
Tositumomab-Compound 17 linker
[200]
Tositumomab-Compound 25
Tositumomab
MS4A1
Monomethyl auristatin E
Tositumomab-Compound 25 linker
[200]
Tositumomab-Compound 31
Tositumomab
MS4A1
Auristatin 0101
Tositumomab-Compound 31 linker
[200]
Tositumomab-Compound 36
Tositumomab
MS4A1
Monomethyl auristatin E
Tositumomab-Compound 36 linker
[200]
Tositumomab-Compound 55
Tositumomab
MS4A1
Mertansine DM1
Tositumomab-Compound 55 linker
[200]
Tositumomab-Compound 59
Tositumomab
MS4A1
Mertansine DM4
Tositumomab-Compound 59 linker
[200]
Tositumomab-Compound 64
Tositumomab
MS4A1
Monomethyl auristatin E
Tositumomab-Compound 64 linker
[200]
Tositumomab-Compound 69
Tositumomab
MS4A1
Monomethyl auristatin E
Tositumomab-Compound 69 linker
[200]
Tositumomab-Compound 75
Tositumomab
MS4A1
Monomethyl auristatin E
Tositumomab-Compound 75 linker
[200]
Tositumomab-Compound 76
Tositumomab
MS4A1
Monomethyl auristatin E
Tositumomab-Compound 76 linker
[200]
Tositumomab-Compound 77
Tositumomab
MS4A1
Mertansine DM1
Tositumomab-Compound 77 linker
[200]
Tositumomab-Compound 78
Tositumomab
MS4A1
Auristatin 0101
Tositumomab-Compound 78 linker
[200]
Tositumomab-Compound 79
Tositumomab
MS4A1
Auristatin 0101
Tositumomab-Compound 79 linker
[200]
Tositumomab-Compound 80
Tositumomab
MS4A1
Mertansine DM4
Tositumomab-Compound 80 linker
[200]
Tositumomab-Compound 9
Tositumomab
MS4A1
Mertansine DM1
Tositumomab-Compound 9 linker
[200]
T-Py-DM1
Trastuzumab
Undisclosed
Mertansine DM1
TCO-PEG3-Mal
[285]
Tras-Gly5-May
Trastuzumab
ERBB2
Mertansine DM1
Gly5
[269]
Trastuzumab biosimilar mil40 12a
Mil40
ERBB2
Monomethyl auristatin E
Maleamic methyl ester-based Val-Ala-PABC linker 12a
[418]
Trastuzumab biosimilar mil40 12b
Mil40
ERBB2
Monomethyl auristatin E
Maleamic methyl ester-based Val-Ala-PABC linker 12b
[418]
Trastuzumab biosimilar mil40 12c
Mil40
ERBB2
Monomethyl auristatin E
Maleamic methyl ester-based Val-Cit-PABC linker 12c
[418]
Trastuzumab deglycosylated WT-MMAE
Trastuzumab I253Q
ERBB2
Monomethyl auristatin E
Dansylcadaverine deglycosylated-BCN based linker
[419]
Trastuzumab DVD-ADC
Trastuzumab
ERBB2
Monomethyl auristatin F
Hexapeptide linker ASTKGP
[241]
Trastuzumab I253Q-MMAE
Trastuzumab I253Q
ERBB2
Monomethyl auristatin E
Dansylcadaverine-BCN based linker
[419]
Trastuzumab/nab-paclitaxel
Trastuzumab
ERBB2
Paclitaxel
Undisclosed
[420]
Trastuzumab-AJICAP-maytansinoid
Trastuzumab
ERBB2
Mertansine DM1
AJICAP
[421]
Trastuzumab-BCN-HydraSpace-Val-Cit-PABC-MMAE
Trastuzumab
ERBB2
Monomethyl auristatin E
BCN-HydraSpace-Val-Cit-PABC
[422]
Trastuzumab-Compound 17
Trastuzumab
ERBB2
Mertansine DM4
Trastuzumab-Compound 17 linker
[200]
Trastuzumab-Compound 25
Trastuzumab
ERBB2
Monomethyl auristatin E
Trastuzumab-Compound 25 linker
[200]
Trastuzumab-Compound 31
Trastuzumab
ERBB2
Auristatin 0101
Trastuzumab-Compound 31 linker
[200]
Trastuzumab-Compound 36
Trastuzumab
ERBB2
Monomethyl auristatin E
Trastuzumab-Compound 36 linker
[200]
Trastuzumab-Compound 55
Trastuzumab
ERBB2
Mertansine DM1
Trastuzumab-Compound 55 linker
[200]
Trastuzumab-Compound 59
Trastuzumab
ERBB2
Mertansine DM4
Trastuzumab-Compound 59 linker
[200]
Trastuzumab-Compound 64
Trastuzumab
ERBB2
Monomethyl auristatin E
Trastuzumab-Compound 64 linker
[200]
Trastuzumab-Compound 69
Trastuzumab
ERBB2
Monomethyl auristatin E
Trastuzumab-Compound 69 linker
[200]
Trastuzumab-Compound 75
Trastuzumab
ERBB2
Monomethyl auristatin E
Trastuzumab-Compound 75 linker
[200]
Trastuzumab-Compound 76
Trastuzumab
ERBB2
Monomethyl auristatin E
Trastuzumab-Compound 76 linker
[200]
Trastuzumab-Compound 77
Trastuzumab
ERBB2
Mertansine DM1
Trastuzumab-Compound 77 linker
[200]
Trastuzumab-Compound 78
Trastuzumab
ERBB2
Auristatin 0101
Trastuzumab-Compound 78 linker
[200]
Trastuzumab-Compound 79
Trastuzumab
ERBB2
Auristatin 0101
Trastuzumab-Compound 79 linker
[200]
Trastuzumab-Compound 80
Trastuzumab
ERBB2
Mertansine DM4
Trastuzumab-Compound 80 linker
[200]
Trastuzumab-Compound 9
Trastuzumab
ERBB2
Mertansine DM1
Trastuzumab-Compound 9 linker
[200]
Trastuzumab-deBouganin
Trastuzumab
ERBB2
DeBouganin
Undisclosed
[423]
Trastuzumab-DVP-linker-MMAE 1
Trastuzumab
ERBB2
Monomethyl auristatin E
DVP-based linker 1f
[424]
Trastuzumab-DVP-linker-MMAE 3
Trastuzumab
ERBB2
Monomethyl auristatin E
DVP-based linker 3
[424]
Trastuzumab-DVP-linker-MMAE 4
Trastuzumab
ERBB2
Monomethyl auristatin E
DVP-based linker 4
[424]
Trastuzumab-Gal-beta-1,4GlcNAc-MMAE
Trastuzumab
ERBB2
Monomethyl auristatin E
Gal-beta-1,4-GlcNAc
[425]
Trastuzumab-Glc-beta-1,4GlcNAc-MMAE
Trastuzumab
ERBB2
Monomethyl auristatin E
Glc-beta-1,4GlcNAc
[425]
Trastuzumab-iCME
Trastuzumab
ERBB2
Membrane-impermable colchinolmethyl ether (iCME) cytotoxin
Pacific blue fluorophore-SH based linker
[426]
Trastuzumab-Man-beta-1,4GlcNAc-MMAE
Trastuzumab
ERBB2
Monomethyl auristatin E
Man-beta-1,4-GlcNAc
[425]
Trastuzumab-MMAE conjugate DAR12
Trastuzumab
ERBB2
Monomethyl auristatin E
Man-beta-1,4-GlcNAc-DBCO-PEG5-VC-PAB
[427]
Trastuzumab-MMAE conjugate DAR2
Trastuzumab
ERBB2
Monomethyl auristatin E
Man-beta-1,4-GlcNAc-DBCO-PEG5-VC-PAB
[427]
Trastuzumab-MMAE conjugate DAR4
Trastuzumab
ERBB2
Monomethyl auristatin E
Man-beta-1,4-GlcNAc-DBCO-PEG5-VC-PAB
[427]
Trastuzumab-MMAE conjugate DAR6
Trastuzumab
ERBB2
Monomethyl auristatin E
Man-beta-1,4-GlcNAc-DBCO-PEG5-VC-PAB
[427]
Trastuzumab-MMAE conjugate DAR8
Trastuzumab
ERBB2
Monomethyl auristatin E
Man-beta-1,4-GlcNAc-DBCO-PEG5-VC-PAB
[427]
Trastuzumab-SYNtansine
Trastuzumab
ERBB2
Ahx-maytansine
BCN-HydraSpace-Val-Cit-PABC
[422]
Trastuzumab-Val-Cit linker-MMAE 2
Trastuzumab
ERBB2
Monomethyl auristatin E
Val-Cit linker 2e
[424]
TTZ-1-MMAE
Trastuzumab
ERBB2
Monomethyl auristatin E
DSPh-Val-Ala-PABC
[428]
TTZ-2-MMAE
Trastuzumab
ERBB2
Monomethyl auristatin E
DSPh-Val-Cit-PABC
[428]
TTZ-3-MMAE
Trastuzumab
ERBB2
Monomethyl auristatin E
DSPh-PEG12-Val-Ala-PABC
[428]
TTZ-4-MMAE
Trastuzumab
ERBB2
Monomethyl auristatin E
DSPh-PEG12-Val-Cit-PABC
[428]
TTZ-Mc-NPV-MMAE
Trastuzumab
ERBB2
Monomethyl auristatin E
Mc-Asn-Pro-Val-PABC
[429]
VCit ADC 3a
Anti-HER2 mAb glutamine 295 (Q295)
ERBB2
Monomethyl auristatin F
DBCO-PEG-VCit-PABC
[310]
Wild type nBT062-DM4
Indatuximab
SDC1
Mertansine DM4
N-succinimidyl 4-(2-pyridyldithio) butanoate (SPDB)
[263]
WO2007011968A2 c1F6-9a
Anti-CD70 mAb c1F6
CD70
Monomethyl auristatin E
WO2007011968A2_c1F6-9a linker
[430]
WO2007011968A2 c1F6-9b
Anti-CD70 mAb c1F6
CD70
Monomethyl auristatin F
WO2007011968A2_c1F6-9b linker
[430]
WO2007011968A2 cAC10-9a
Brentuximab
TNFRSF8
Monomethyl auristatin E
WO2007011968A2_cAC10-9a linker
[430]
WO2007011968A2 cAC10-9b
Brentuximab
TNFRSF8
Monomethyl auristatin F
WO2007011968A2_cAC10-9b linker
[430]
WO2015095755A1 cAC10-1.3
Brentuximab
TNFRSF8
Monomethyl auristatin E
WO2015095755A1_cAC10-1.3 linker
[431]
WO2015095755A1 cAC10-2.0
Brentuximab
TNFRSF8
Monomethyl auristatin E
WO2015095755A1_cAC10-2.0 linker
[431]
WO2015095755A1 h1F6-1.3
Anti-CD70 mAb h1F6
CD70
Monomethyl auristatin E
WO2015095755A1_h1F6-1.3 linker
[431]
WO2015095755A1 h1F6-2.0
Anti-CD70 mAb h1F6
CD70
Monomethyl auristatin E
WO2015095755A1_h1F6-2.0 linker
[431]
WO2015177360A1 ADC-H8-HC40-mcMMAF
Anti-5T4 mAb H8 S40C
TPBG
Monomethyl auristatin F
Maleimido-caproyl
[432]
WO2015177360A1 ADC-H8-HC40-vcMMAE
Anti-5T4 mAb H8 S40C
TPBG
Monomethyl auristatin E
Mc-Val-Cit-PABC
[432]
WO2015177360A1 ADC-H8-wt-mcMMAF
Anti-5T4 mAb H8 wt
TPBG
Monomethyl auristatin F
Maleimido-caproyl
[432]
WO2015177360A1 ADC-HC41-mcMMAF
Anti-PSMA mAb wt HC S41C
FOLH1
Monomethyl auristatin F
Maleimido-caproyl
[432]
WO2015177360A1 ADC-HC41-vcMMAE
Anti-PSMA mAb wt HC S41C
FOLH1
Monomethyl auristatin E
Mc-Val-Cit-PABC
[432]
WO2015177360A1 ADC-LC40-mcMMAF
Anti-PSMA mAb wt LC P40C
FOLH1
Monomethyl auristatin F
Maleimido-caproyl
[432]
WO2015177360A1 ADC-LC40-vcMMAE
Anti-PSMA mAb wt LC P40C
FOLH1
Monomethyl auristatin E
Mc-Val-Cit-PABC
[432]
WO2015177360A1 ADC-LC41-mcMMAF
Anti-PSMA mAb wt LC G41C
FOLH1
Monomethyl auristatin F
Maleimido-caproyl
[432]
WO2015177360A1 ADC-LC41-vcMMAE
Anti-PSMA mAb wt LC G41C
FOLH1
Monomethyl auristatin E
Mc-Val-Cit-PABC
[432]
WO2015177360A1 ADC-wt-mcMMAF
Anti-PSMA mAb wt
FOLH1
Monomethyl auristatin F
Maleimido-caproyl
[432]
WO2015177360A1 ADC-wt-vcMMAE
Anti-PSMA mAb wt
FOLH1
Monomethyl auristatin E
Mc-Val-Cit-PABC
[432]
WO2017089890A1 ADC1
Trastuzumab
ERBB2
Monomethyl auristatin E
WO2017089890A1_ADC1 linker
[433]
WO2017089890A1 ADC10
Trastuzumab
ERBB2
Monomethyl auristatin E
WO2017089890A1_ADC10 linker
[433]
WO2017089890A1 ADC11
Trastuzumab
ERBB2
Monomethyl auristatin E
WO2017089890A1_ADC11 linker
[433]
WO2017089890A1 ADC12
Trastuzumab
ERBB2
Monomethyl auristatin E
WO2017089890A1_ADC12 linker
[433]
WO2017089890A1 ADC13
Trastuzumab
ERBB2
Monomethyl auristatin E
WO2017089890A1_ADC13 linker
[433]
WO2017089890A1 ADC14
Trastuzumab
ERBB2
Monomethyl auristatin F
WO2017089890A1_ADC14 linker
[433]
WO2017089890A1 ADC15
Trastuzumab
ERBB2
Monomethyl auristatin E
WO2017089890A1_ADC15 linker
[433]
WO2017089890A1 ADC16
Trastuzumab
ERBB2
Monomethyl auristatin F
WO2017089890A1_ADC16 linker
[433]
WO2017089890A1 ADC17
Trastuzumab
ERBB2
Monomethyl auristatin E
WO2017089890A1_ADC17 linker
[433]
WO2017089890A1 ADC18
Trastuzumab
ERBB2
Monomethyl auristatin F
WO2017089890A1_ADC18 linker
[433]
WO2017089890A1 ADC19
Trastuzumab
ERBB2
Monomethyl auristatin E
WO2017089890A1_ADC19 linker
[433]
WO2017089890A1 ADC2
Trastuzumab
ERBB2
Monomethyl auristatin F
WO2017089890A1_ADC2 linker
[433]
WO2017089890A1 ADC20
Trastuzumab
ERBB2
Monomethyl auristatin F
WO2017089890A1_ADC20 linker
[433]
WO2017089890A1 ADC23
Trastuzumab
ERBB2
Monomethyl auristatin F
WO2017089890A1_ADC23 linker
[433]
WO2017089890A1 ADC24
Trastuzumab
ERBB2
Monomethyl auristatin E
WO2017089890A1_ADC24 linker
[433]
WO2017089890A1 ADC25
Trastuzumab
ERBB2
Monomethyl auristatin E
WO2017089890A1_ADC25 linker
[433]
WO2017089890A1 ADC26
Trastuzumab
ERBB2
Monomethyl auristatin E
WO2017089890A1_ADC26 linker
[433]
WO2017089890A1 ADC27
Trastuzumab
ERBB2
Monomethyl auristatin E
WO2017089890A1_ADC27 linker
[433]
WO2017089890A1 ADC28
Trastuzumab
ERBB2
Monomethyl auristatin E
WO2017089890A1_ADC28 linker
[433]
WO2017089890A1 ADC29
Trastuzumab
ERBB2
Monomethyl auristatin E
WO2017089890A1_ADC29 linker
[433]
WO2017089890A1 ADC3
Trastuzumab
ERBB2
Monomethyl auristatin E
WO2017089890A1_ADC3 linker
[433]
WO2017089890A1 ADC30
Trastuzumab
ERBB2
Monomethyl auristatin E
WO2017089890A1_ADC30 linker
[433]
WO2017089890A1 ADC31
Trastuzumab
ERBB2
Monomethyl auristatin E
WO2017089890A1_ADC31 linker
[433]
WO2017089890A1 ADC32
Trastuzumab
ERBB2
Monomethyl auristatin E
WO2017089890A1_ADC32 linker
[433]
WO2017089890A1 ADC33
Trastuzumab
ERBB2
Monomethyl auristatin E
WO2017089890A1_ADC33 linker
[433]
WO2017089890A1 ADC34
Trastuzumab
ERBB2
Monomethyl auristatin F
WO2017089890A1_ADC34 linker
[433]
WO2017089890A1 ADC35
Trastuzumab
ERBB2
Monomethyl auristatin E
WO2017089890A1_ADC35 linker
[433]
WO2017089890A1 ADC36
Trastuzumab
ERBB2
Monomethyl auristatin E
WO2017089890A1_ADC36 linker
[433]
WO2017089890A1 ADC37
Trastuzumab
ERBB2
Monomethyl auristatin E
WO2017089890A1_ADC37 linker
[433]
WO2017089890A1 ADC38
Trastuzumab
ERBB2
Monomethyl auristatin F
WO2017089890A1_ADC38 linker
[433]
WO2017089890A1 ADC39
Trastuzumab
ERBB2
Monomethyl auristatin E
WO2017089890A1_ADC39 linker
[433]
WO2017089890A1 ADC4
Trastuzumab
ERBB2
Monomethyl auristatin F
WO2017089890A1_ADC4 linker
[433]
WO2017089890A1 ADC40
Trastuzumab
ERBB2
Monomethyl auristatin F
WO2017089890A1_ADC40 linker
[433]
WO2017089890A1 ADC41
Trastuzumab
ERBB2
Monomethyl auristatin E
WO2017089890A1_ADC41 linker
[433]
WO2017089890A1 ADC42
Trastuzumab
ERBB2
Monomethyl auristatin F
WO2017089890A1_ADC42 linker
[433]
WO2017089890A1 ADC43
Trastuzumab
ERBB2
Monomethyl auristatin E
WO2017089890A1_ADC43 linker
[433]
WO2017089890A1 ADC44
Trastuzumab
ERBB2
Monomethyl auristatin F
WO2017089890A1_ADC44 linker
[433]
WO2017089890A1 ADC45
Trastuzumab
ERBB2
Monomethyl auristatin E
WO2017089890A1_ADC45 linker
[433]
WO2017089890A1 ADC46
Trastuzumab
ERBB2
Monomethyl auristatin F
WO2017089890A1_ADC46 linker
[433]
WO2017089890A1 ADC47
Trastuzumab
ERBB2
Monomethyl auristatin E
WO2017089890A1_ADC47 linker
[433]
WO2017089890A1 ADC48
Trastuzumab
ERBB2
Monomethyl auristatin F
WO2017089890A1_ADC48 linker
[433]
WO2017089890A1 ADC49
Trastuzumab
ERBB2
Monomethyl auristatin E
WO2017089890A1_ADC49 linker
[433]
WO2017089890A1 ADC5
Trastuzumab
ERBB2
Monomethyl auristatin E
WO2017089890A1_ADC5 linker
[433]
WO2017089890A1 ADC50
Trastuzumab
ERBB2
Monomethyl auristatin F
WO2017089890A1_ADC50 linker
[433]
WO2017089890A1 ADC51
Trastuzumab
ERBB2
Monomethyl auristatin E
WO2017089890A1_ADC51 linker
[433]
WO2017089890A1 ADC52
Trastuzumab
ERBB2
Monomethyl auristatin E
WO2017089890A1_ADC52 linker
[433]
WO2017089890A1 ADC53
Trastuzumab
ERBB2
Monomethyl auristatin E
WO2017089890A1_ADC53 linker
[433]
WO2017089890A1 ADC54
Trastuzumab
ERBB2
Monomethyl auristatin F
WO2017089890A1_ADC54 linker
[433]
WO2017089890A1 ADC55
Trastuzumab
ERBB2
Monomethyl auristatin E
WO2017089890A1_ADC55 linker
[433]
WO2017089890A1 ADC6
Trastuzumab
ERBB2
Monomethyl auristatin F
WO2017089890A1_ADC6 linker
[433]
WO2017089890A1 ADC60
Trastuzumab
ERBB2
Monomethyl auristatin F
WO2017089890A1_ADC60 linker
[433]
WO2017089890A1 ADC61
Trastuzumab
ERBB2
Monomethyl auristatin E
WO2017089890A1_ADC61 linker
[433]
WO2017089890A1 ADC62
Trastuzumab
ERBB2
Monomethyl auristatin F
WO2017089890A1_ADC62 linker
[433]
WO2017089890A1 ADC63
Trastuzumab
ERBB2
Monomethyl auristatin E
WO2017089890A1_ADC63 linker
[433]
WO2017089890A1 ADC64
Cetuximab
EGFR
Monomethyl auristatin F
WO2017089890A1_ADC64 linker
[433]
WO2017089890A1 ADC65
Cetuximab
EGFR
Monomethyl auristatin E
WO2017089890A1_ADC65 linker
[433]
WO2017089890A1 ADC66
Cetuximab
EGFR
Monomethyl auristatin F
WO2017089890A1_ADC66 linker
[433]
WO2017089890A1 ADC67
Anti-CD19 mAb DI-B4
CD19
Monomethyl auristatin F
WO2017089890A1_ADC67 linker
[433]
WO2017089890A1 ADC68
Anti-CD19 mAb DI-B4
CD19
Monomethyl auristatin E
WO2017089890A1_ADC68 linker
[433]
WO2017089890A1 ADC69
Anti-CD19 mAb DI-B4
CD19
Monomethyl auristatin F
WO2017089890A1_ADC69 linker
[433]
WO2017089890A1 ADC7
Trastuzumab
ERBB2
Monomethyl auristatin E
WO2017089890A1_ADC7 linker
[433]
WO2017089890A1 ADC70
Rituximab
MS4A1
Monomethyl auristatin F
WO2017089890A1_ADC70 linker
[433]
WO2017089890A1 ADC71
Rituximab
MS4A1
Monomethyl auristatin E
WO2017089890A1_ADC71 linker
[433]
WO2017089890A1 ADC72
Rituximab
MS4A1
Monomethyl auristatin F
WO2017089890A1_ADC72 linker
[433]
WO2017089890A1 ADC73
Depatuxizumab
EGFR
Monomethyl auristatin F
WO2017089890A1_ADC73 linker
[433]
WO2017089890A1 ADC74
Depatuxizumab
EGFR
Monomethyl auristatin E
WO2017089890A1_ADC74 linker
[433]
WO2017089890A1 ADC75
Depatuxizumab
EGFR
Monomethyl auristatin F
WO2017089890A1_ADC75 linker
[433]
WO2017089890A1 ADC76
Trastuzumab
ERBB2
Monomethyl auristatin F
WO2017089890A1_ADC76 linker
[433]
WO2017089890A1 ADC77
Trastuzumab
ERBB2
Monomethyl auristatin F
WO2017089890A1_ADC77 linker
[433]
WO2017089890A1 ADC8
Trastuzumab
ERBB2
Monomethyl auristatin F
WO2017089890A1_ADC8 linker
[433]
WO2017089890A1 ADC86
Trastuzumab
ERBB2
Monomethyl auristatin F
WO2017089890A1_ADC86 linker
[433]
WO2017089890A1 ADC87
Trastuzumab
ERBB2
Monomethyl auristatin E
WO2017089890A1_ADC87 linker
[433]
WO2017089890A1 ADC88
Trastuzumab
ERBB2
Monomethyl auristatin F
WO2017089890A1_ADC88 linker
[433]
WO2017089890A1 ADC89
Trastuzumab
ERBB2
Monomethyl auristatin E
WO2017089890A1_ADC89 linker
[433]
WO2017089890A1 ADC9
Trastuzumab
ERBB2
Monomethyl auristatin E
WO2017089890A1_ADC9 linker
[433]
WO2017089890A1 ADC90
Trastuzumab
ERBB2
Monomethyl auristatin F
WO2017089890A1_ADC90 linker
[433]
WO2017089890A1 ADC91
Trastuzumab
ERBB2
Monomethyl auristatin E
WO2017089890A1_ADC91 linker
[433]
WO2017089895A1 ADC1
Trastuzumab
ERBB2
Monomethyl auristatin E
WO2017089895A1_ADC1 linker
[434]
WO2017089895A1 ADC10
Trastuzumab
ERBB2
Monomethyl auristatin E
WO2017089895A1_ADC10 linker
[434]
WO2017089895A1 ADC11
Trastuzumab
ERBB2
Monomethyl auristatin E
WO2017089895A1_ADC11 linker
[434]
WO2017089895A1 ADC12
Trastuzumab
ERBB2
Monomethyl auristatin E
WO2017089895A1_ADC12 linker
[434]
WO2017089895A1 ADC13
Trastuzumab
ERBB2
Monomethyl auristatin E
WO2017089895A1_ADC13 linker
[434]
WO2017089895A1 ADC14
Trastuzumab
ERBB2
Monomethyl auristatin F
WO2017089895A1_ADC14 linker
[434]
WO2017089895A1 ADC15
Trastuzumab
ERBB2
Monomethyl auristatin E
WO2017089895A1_ADC15 linker
[434]
WO2017089895A1 ADC16
Trastuzumab
ERBB2
Monomethyl auristatin F
WO2017089895A1_ADC16 linker
[434]
WO2017089895A1 ADC17
Trastuzumab
ERBB2
Monomethyl auristatin E
WO2017089895A1_ADC17 linker
[434]
WO2017089895A1 ADC18
Trastuzumab
ERBB2
Monomethyl auristatin F
WO2017089895A1_ADC18 linker
[434]
WO2017089895A1 ADC19
Trastuzumab
ERBB2
Monomethyl auristatin E
WO2017089895A1_ADC19 linker
[434]
WO2017089895A1 ADC2
Trastuzumab
ERBB2
Monomethyl auristatin F
WO2017089895A1_ADC2 linker
[434]
WO2017089895A1 ADC20
Trastuzumab
ERBB2
Monomethyl auristatin F
WO2017089895A1_ADC20 linker
[434]
WO2017089895A1 ADC23
Trastuzumab
ERBB2
Monomethyl auristatin F
WO2017089895A1_ADC23 linker
[434]
WO2017089895A1 ADC24
Trastuzumab
ERBB2
Monomethyl auristatin E
WO2017089895A1_ADC24 linker
[434]
WO2017089895A1 ADC25
Trastuzumab
ERBB2
Monomethyl auristatin E
WO2017089895A1_ADC25 linker
[434]
WO2017089895A1 ADC26
Trastuzumab
ERBB2
Monomethyl auristatin E
WO2017089895A1_ADC26 linker
[434]
WO2017089895A1 ADC27
Trastuzumab
ERBB2
Monomethyl auristatin E
WO2017089895A1_ADC27 linker
[434]
WO2017089895A1 ADC28
Trastuzumab
ERBB2
Monomethyl auristatin E
WO2017089895A1_ADC28 linker
[434]
WO2017089895A1 ADC29
Trastuzumab
ERBB2
Monomethyl auristatin E
WO2017089895A1_ADC29 linker
[434]
WO2017089895A1 ADC3
Trastuzumab
ERBB2
Monomethyl auristatin E
WO2017089895A1_ADC3 linker
[434]
WO2017089895A1 ADC30
Trastuzumab
ERBB2
Monomethyl auristatin E
WO2017089895A1_ADC30 linker
[434]
WO2017089895A1 ADC31
Trastuzumab
ERBB2
Monomethyl auristatin E
WO2017089895A1_ADC31 linker
[434]
WO2017089895A1 ADC32
Trastuzumab
ERBB2
Monomethyl auristatin E
WO2017089895A1_ADC32 linker
[434]
WO2017089895A1 ADC33
Trastuzumab
ERBB2
Monomethyl auristatin E
WO2017089895A1_ADC33 linker
[434]
WO2017089895A1 ADC34
Trastuzumab
ERBB2
Monomethyl auristatin F
WO2017089895A1_ADC34 linker
[434]
WO2017089895A1 ADC35
Trastuzumab
ERBB2
Monomethyl auristatin E
WO2017089895A1_ADC35 linker
[434]
WO2017089895A1 ADC36
Trastuzumab
ERBB2
Monomethyl auristatin E
WO2017089895A1_ADC36 linker
[434]
WO2017089895A1 ADC37
Trastuzumab
ERBB2
Monomethyl auristatin E
WO2017089895A1_ADC37 linker
[434]
WO2017089895A1 ADC38
Trastuzumab
ERBB2
Monomethyl auristatin F
WO2017089895A1_ADC38 linker
[434]
WO2017089895A1 ADC39
Trastuzumab
ERBB2
Monomethyl auristatin E
WO2017089895A1_ADC39 linker
[434]
WO2017089895A1 ADC4
Trastuzumab
ERBB2
Monomethyl auristatin F
WO2017089895A1_ADC4 linker
[434]
WO2017089895A1 ADC40
Trastuzumab
ERBB2
Monomethyl auristatin F
WO2017089895A1_ADC40 linker
[434]
WO2017089895A1 ADC41
Trastuzumab
ERBB2
Monomethyl auristatin E
WO2017089895A1_ADC41 linker
[434]
WO2017089895A1 ADC42
Trastuzumab
ERBB2
Monomethyl auristatin F
WO2017089895A1_ADC42 linker
[434]
WO2017089895A1 ADC43
Trastuzumab
ERBB2
Monomethyl auristatin E
WO2017089895A1_ADC43 linker
[434]
WO2017089895A1 ADC44
Trastuzumab
ERBB2
Monomethyl auristatin F
WO2017089895A1_ADC44 linker
[434]
WO2017089895A1 ADC45
Trastuzumab
ERBB2
Monomethyl auristatin E
WO2017089895A1_ADC45 linker
[434]
WO2017089895A1 ADC46
Trastuzumab
ERBB2
Monomethyl auristatin F
WO2017089895A1_ADC46 linker
[434]
WO2017089895A1 ADC47
Trastuzumab
ERBB2
Monomethyl auristatin E
WO2017089895A1_ADC47 linker
[434]
WO2017089895A1 ADC48
Trastuzumab
ERBB2
Monomethyl auristatin F
WO2017089895A1_ADC48 linker
[434]
WO2017089895A1 ADC49
Trastuzumab
ERBB2
Monomethyl auristatin E
WO2017089895A1_ADC49 linker
[434]
WO2017089895A1 ADC5
Trastuzumab
ERBB2
Monomethyl auristatin E
WO2017089895A1_ADC5 linker
[434]
WO2017089895A1 ADC50
Trastuzumab
ERBB2
Monomethyl auristatin F
WO2017089895A1_ADC50 linker
[434]
WO2017089895A1 ADC51
Trastuzumab
ERBB2
Monomethyl auristatin E
WO2017089895A1_ADC51 linker
[434]
WO2017089895A1 ADC52
Trastuzumab
ERBB2
Monomethyl auristatin E
WO2017089895A1_ADC52 linker
[434]
WO2017089895A1 ADC53
Trastuzumab
ERBB2
Monomethyl auristatin F
WO2017089895A1_ADC53 linker
[434]
WO2017089895A1 ADC54
Trastuzumab
ERBB2
Monomethyl auristatin F
WO2017089895A1_ADC54 linker
[434]
WO2017089895A1 ADC55
Trastuzumab
ERBB2
Monomethyl auristatin F
WO2017089895A1_ADC55 linker
[434]
WO2017089895A1 ADC6
Trastuzumab
ERBB2
Monomethyl auristatin F
WO2017089895A1_ADC6 linker
[434]
WO2017089895A1 ADC60
Trastuzumab
ERBB2
Monomethyl auristatin F
WO2017089895A1_ADC60 linker
[434]
WO2017089895A1 ADC61
Trastuzumab
ERBB2
Monomethyl auristatin E
WO2017089895A1_ADC61 linker
[434]
WO2017089895A1 ADC62
Trastuzumab
ERBB2
Monomethyl auristatin F
WO2017089895A1_ADC62 linker
[434]
WO2017089895A1 ADC63
Trastuzumab
ERBB2
Monomethyl auristatin E
WO2017089895A1_ADC63 linker
[434]
WO2017089895A1 ADC64
Cetuximab
EGFR
Monomethyl auristatin F
WO2017089895A1_ADC64 linker
[434]
WO2017089895A1 ADC65
Cetuximab
EGFR
Monomethyl auristatin E
WO2017089895A1_ADC65 linker
[434]
WO2017089895A1 ADC66
Cetuximab
EGFR
Monomethyl auristatin F
WO2017089895A1_ADC66 linker
[434]
WO2017089895A1 ADC67
Anti-CD19 mAb DI-B4
CD19
Monomethyl auristatin F
WO2017089895A1_ADC67 linker
[434]
WO2017089895A1 ADC68
Anti-CD19 mAb DI-B4
CD19
Monomethyl auristatin E
WO2017089895A1_ADC68 linker
[434]
WO2017089895A1 ADC69
Anti-CD19 mAb DI-B4
CD19
Monomethyl auristatin F
WO2017089895A1_ADC69 linker
[434]
WO2017089895A1 ADC7
Trastuzumab
ERBB2
Monomethyl auristatin E
WO2017089895A1_ADC7 linker
[434]
WO2017089895A1 ADC70
Rituximab
MS4A1
Monomethyl auristatin F
WO2017089895A1_ADC70 linker
[434]
WO2017089895A1 ADC71
Rituximab
MS4A1
Monomethyl auristatin E
WO2017089895A1_ADC71 linker
[434]
WO2017089895A1 ADC72
Rituximab
MS4A1
Monomethyl auristatin F
WO2017089895A1_ADC72 linker
[434]
WO2017089895A1 ADC73
Depatuxizumab
EGFRvIII
Monomethyl auristatin F
WO2017089895A1_ADC73 linker
[434]
WO2017089895A1 ADC74
Depatuxizumab
EGFRvIII
Monomethyl auristatin E
WO2017089895A1_ADC74 linker
[434]
WO2017089895A1 ADC75
Depatuxizumab
EGFRvIII
Monomethyl auristatin F
WO2017089895A1_ADC75 linker
[434]
WO2017089895A1 ADC76
Trastuzumab
ERBB2
Monomethyl auristatin F
WO2017089895A1_ADC76 linker
[434]
WO2017089895A1 ADC77
Trastuzumab
ERBB2
Monomethyl auristatin F
WO2017089895A1_ADC77 linker
[434]
WO2017089895A1 ADC8
Trastuzumab
ERBB2
Monomethyl auristatin F
WO2017089895A1_ADC8 linker
[434]
WO2017089895A1 ADC86
Trastuzumab
ERBB2
Monomethyl auristatin F
WO2017089895A1_ADC86 linker
[434]
WO2017089895A1 ADC87
Trastuzumab
ERBB2
Monomethyl auristatin E
WO2017089895A1_ADC87 linker
[434]
WO2017089895A1 ADC88
Trastuzumab
ERBB2
Monomethyl auristatin F
WO2017089895A1_ADC88 linker
[434]
WO2017089895A1 ADC89
Trastuzumab
ERBB2
Monomethyl auristatin F
WO2017089895A1_ADC89 linker
[434]
WO2017089895A1 ADC9
Trastuzumab
ERBB2
Monomethyl auristatin E
WO2017089895A1_ADC9 linker
[434]
WO2017089895A1 ADC90
Trastuzumab
ERBB2
Monomethyl auristatin F
WO2017089895A1_ADC90 linker
[434]
WO2017089895A1 ADC91
Trastuzumab
ERBB2
Monomethyl auristatin E
WO2017089895A1_ADC91 linker
[434]
WO2021044208A1 ADC 2A2-4
Anti-ROR1 mAb 2A2
ROR1
Monomethyl auristatin E
WO2021044208A1_ADC 2A2-4 linker
[435]
WO2021044208A1 ADC 2A2-5
Anti-ROR1 mAb 2A2
ROR1
Monomethyl auristatin E
WO2021044208A1_ADC 2A2-5 linker
[435]
WO2021044208A1 ADC A2F2 M1-2
Anti-ROR1 mAb A2F2 M1
ROR1
Monomethyl auristatin F
WO2021044208A1_ADC A2F2 M1-2 linker
[435]
WO2021044208A1 ADC A2F2 M1-3
Anti-ROR1 mAb A2F2 M1
ROR1
Monomethyl auristatin E
WO2021044208A1_ADC A2F2 M1-3 linker
[435]
WO2021044208A1 ADC A2F2 M1-4
Anti-ROR1 mAb A2F2 M1
ROR1
Monomethyl auristatin E
WO2021044208A1_ADC A2F2 M1-4 linker
[435]
WO2021044208A1 ADC A2F2 M1-5
Anti-ROR1 mAb A2F2 M1
ROR1
Monomethyl auristatin E
WO2021044208A1_ADC A2F2 M1-5 linker
[435]
WO2021044208A1 ADC A2F2-2
Anti-ROR1 mAb A2F2
ROR1
Monomethyl auristatin F
WO2021044208A1_ADC A2F2-2 linker
[435]
WO2021044208A1 ADC A2F2-3
Anti-ROR1 mAb A2F2
ROR1
Monomethyl auristatin E
WO2021044208A1_ADC A2F2-3 linker
[435]
WO2021044208A1 ADC A2F2-4
Anti-ROR1 mAb A2F2
ROR1
Monomethyl auristatin E
WO2021044208A1_ADC A2F2-4 linker
[435]
WO2021044208A1 ADC A2F2-5
Anti-ROR1 mAb A2F2
ROR1
Monomethyl auristatin E
WO2021044208A1_ADC A2F2-5 linker
[435]
WO2021044208A1 ADC A2F3-2
Anti-ROR1 mAb A2F3
ROR1
Monomethyl auristatin F
WO2021044208A1_ADC A2F3-2 linker
[435]
WO2021044208A1 ADC A2F3-3
Anti-ROR1 mAb A2F3
ROR1
Monomethyl auristatin E
WO2021044208A1_ADC A2F3-3 linker
[435]
WO2021044208A1 ADC A2F3-4
Anti-ROR1 mAb A2F3
ROR1
Monomethyl auristatin E
WO2021044208A1_ADC A2F3-4 linker
[435]
WO2021044208A1 ADC A2F3-5
Anti-ROR1 mAb A2F3
ROR1
Monomethyl auristatin E
WO2021044208A1_ADC A2F3-5 linker
[435]
WO2021044208A1 ADC AB4-2
Anti-ROR1 mAb AB4
ROR1
Monomethyl auristatin F
WO2021044208A1_ADC AB4-2 linker
[435]
WO2021044208A1 ADC AB4-3
Anti-ROR1 mAb AB4
ROR1
Monomethyl auristatin E
WO2021044208A1_ADC AB4-3 linker
[435]
WO2021044208A1 ADC AB4-4
Anti-ROR1 mAb AB4
ROR1
Monomethyl auristatin E
WO2021044208A1_ADC AB4-4 linker
[435]
WO2021044208A1 ADC AB4-5
Anti-ROR1 mAb AB4
ROR1
Monomethyl auristatin E
WO2021044208A1_ADC AB4-5 linker
[435]
WO2021044208A1 ADC BA6-2
Anti-ROR1 mAb BA6
ROR1
Monomethyl auristatin F
WO2021044208A1_ADC BA6-2 linker
[435]
WO2021044208A1 ADC BA6-3
Anti-ROR1 mAb BA6
ROR1
Monomethyl auristatin E
WO2021044208A1_ADC BA6-3 linker
[435]
WO2021044208A1 ADC BA6-4
Anti-ROR1 mAb BA6
ROR1
Monomethyl auristatin E
WO2021044208A1_ADC BA6-4 linker
[435]
WO2021044208A1 ADC BA6-5
Anti-ROR1 mAb BA6
ROR1
Monomethyl auristatin E
WO2021044208A1_ADC BA6-5 linker
[435]
WO2021044208A1 ADC CC9-2
Anti-ROR1 mAb CC9
ROR1
Monomethyl auristatin F
WO2021044208A1_ADC CC9-2 linker
[435]
WO2021044208A1 ADC CC9-3
Anti-ROR1 mAb CC9
ROR1
Monomethyl auristatin E
WO2021044208A1_ADC CC9-3 linker
[435]
WO2021044208A1 ADC CC9-4
Anti-ROR1 mAb CC9
ROR1
Monomethyl auristatin E
WO2021044208A1_ADC CC9-4 linker
[435]
WO2021044208A1 ADC CC9-5
Anti-ROR1 mAb CC9
ROR1
Monomethyl auristatin E
WO2021044208A1_ADC CC9-5 linker
[435]
WO2021044208A1 ADC D2B12-2
Anti-ROR1 mAb D2B12
ROR1
Monomethyl auristatin F
WO2021044208A1_ADC D2B12-2 linker
[435]
WO2021044208A1 ADC D2B12-3
Anti-ROR1 mAb D2B12
ROR1
Monomethyl auristatin E
WO2021044208A1_ADC D2B12-3 linker
[435]
WO2021044208A1 ADC D2B12-4
Anti-ROR1 mAb D2B12
ROR1
Monomethyl auristatin E
WO2021044208A1_ADC D2B12-4 linker
[435]
WO2021044208A1 ADC D2B12-5
Anti-ROR1 mAb D2B12
ROR1
Monomethyl auristatin E
WO2021044208A1_ADC D2B12-5 linker
[435]
WO2021044208A1 ADC DG6-2
Anti-ROR1 mAb DG6
ROR1
Monomethyl auristatin F
WO2021044208A1_ADC DG6-2 linker
[435]
WO2021044208A1 ADC DG6-3
Anti-ROR1 mAb DG6
ROR1
Monomethyl auristatin E
WO2021044208A1_ADC DG6-3 linker
[435]
WO2021044208A1 ADC DG6-4
Anti-ROR1 mAb DG6
ROR1
Monomethyl auristatin E
WO2021044208A1_ADC DG6-4 linker
[435]
WO2021044208A1 ADC DG6-5
Anti-ROR1 mAb DG6
ROR1
Monomethyl auristatin E
WO2021044208A1_ADC DG6-5 linker
[435]
WO2021044208A1 ADC10
Anti-ROR1 mAb 2A2
ROR1
Monomethyl auristatin E
WO2021044208A1_ADC10 linker
[435]
WO2021044208A1 ADC2
Anti-ROR1 mAb C2E3
ROR1
Monomethyl auristatin F
WO2021044208A1_ADC2 linker
[435]
WO2021044208A1 ADC3
Anti-ROR1 mAb C2E3
ROR1
Monomethyl auristatin E
WO2021044208A1_ADC3 linker
[435]
WO2021044208A1 ADC4
Anti-ROR1 mAb C2E3
ROR1
Monomethyl auristatin E
WO2021044208A1_ADC4 linker
[435]
WO2021044208A1 ADC5
Anti-ROR1 mAb C2E3
ROR1
Monomethyl auristatin E
WO2021044208A1_ADC5 linker
[435]
WO2021044208A1 ADC9
Anti-ROR1 mAb 2A2
ROR1
Monomethyl auristatin F
WO2021044208A1_ADC9 linker
[435]
YH-012
Undisclosed
ERBB2; TACSTD2
Monomethyl auristatin E
Mc-Val-Cit-PABC
[436]
YH-013
Undisclosed
EGFR; MET
Monomethyl auristatin E
Mc-Val-Cit-PABC
[437]
Zapadcine-1
Zaptuzumab
TNFRSF10B
Monomethyl auristatin D
PY-VC-PABC
[438]
ZHER2-ABD-mcMMAE
ZHER2-ABD
ERBB2
Monomethyl auristatin E
Maleimido-caproyl
[439]
ZHER2-ABD-mcMMAF
ZHER2-ABD
ERBB2
Monomethyl auristatin F
Maleimido-caproyl
[439]
Zt/g4-DM1
Anti-RON Zt/g4 (IgG1 kappa)
MST1R
Mertansine DM1
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
[440]
Zt/g4-Maytansinoid
Undisclosed
MST1R
Mertansine DM1
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
[440]
Zt/g4-MMAE
Anti-RON Zt/g4 (IgG1 kappa)
MST1R
Monomethyl auristatin E
Mc-Val-Cit-PABC
[441]
ZV-0501
ZV05
TPBG
Monomethyl auristatin F
Maleimido-caproyl
[442]
Terminated
Click To Hide/Show 12 ADC Related to This Stage
ADC Info ADC Name Antibody Antigen Payload Linker Ref
Alpha-CD30-Val-Cit-MMAE
Anti-CD30 alphaCD30-vcMMAE mAb
TNFRSF8
Monomethyl auristatin E
Mc-Val-Cit-PABC
[443]
Alpha-CD70-Mc-MMAF
Chimeric Anti-CD70 Anti-ody
CD70
Monomethyl auristatin E
Mc-Val-Cit-PABC
[444]
Anti-TenB2 antibody drug conjugate
Anti-TENB2 monoclonal Anti-ody (mAb)
TMEFF2
Monomethyl auristatin E
Mc-Val-Cit-PABC
[445]
B-1452
Undisclosed
MS4A1
Monomethyl auristatin E
Mc-Val-Cit-PABC
[446]
B-1453
Undisclosed
TNFSF10
Monomethyl auristatin E
Mc-Val-Cit-PABC
[446]
CD30-BTG-ADC
Anti-CD30 mAb cAC10Q
TNFRSF8
Monomethyl auristatin E
PEG3-benzotriazole-PEG-Val-Cit-PABC
[447]
Cetuximab based antibody-drug conjugate
Cetuximab
EGFR
Mertansine DM1
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
[448]
C-met monoclonal antibody-drug conjugate
STI-D0606
MET
Mertansine DM1
Undisclosed
[449]
EGFRvIII/MMAE antibody drug conjugate
Undisclosed
EGFRvIII
Monomethyl auristatin E
Undisclosed
[450]
FGFR2/FGFR4 dual targeting antibody-drug conjugate
Undisclosed
FGFR2; FGFR4
Mertansine DM1
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
[451]
Fluorescent Antibody-Drug Conjugate
Anti-CEA mAb MIC0101
PSG2
Paclitaxel
Undisclosed
[452]
Trastuzumab-dTSPEG-MMAF
Trastuzumab
ERBB2
Monomethyl auristatin F
dTSPEG
[453]
References
Ref 1 Phase I study of A166, an antibodydrug conjugate in advanced HER2-expressing solid tumours. NPJ Breast Cancer. 2023 Apr 18;9(1):28. doi: 10.1038/s41523-023-00522-5.
Ref 2 First-in-human dose-escalation study of anti-EGFR ADC MRG003 in patients with relapsed/refractory solid tumors. Journal of Clinical Oncology 38, no. 15_suppl (May 20, 2020) 3550-3550.
Ref 3 Belantamab Mafodotin-blmf: A Novel Antibody-Drug Conjugate for Treatment of Patients With Relapsed/Refractory Multiple Myeloma. J Adv Pract Oncol. 2022 Jan;13(1):77-85. doi: 10.6004/jadpro.2022.13.1.7. Epub 2022 Feb 1.
Ref 4 A phase I weekly dosing study of brentuximab vedotin in patients with relapsed/refractory CD30-positive hematologic malignancies. Clin Cancer Res. 2012 Jan 1;18(1):248-55.
Ref 5 Open-label, Multicenter, Phase II Study of RC48-ADC, a HER2-Targeting Antibody-Drug Conjugate, in Patients with Locally Advanced or Metastatic Urothelial Carcinoma. Clin Cancer Res. 2021 Jan 1;27(1):43-51. doi: 10.1158/1078-0432.CCR-20-2488. Epub 2020 Oct 27.
Ref 6 Enfortumab Vedotin in Previously Treated Advanced Urothelial Carcinoma. N Engl J Med. 2021 Mar 25;384(12):1125-1135. doi: 10.1056/NEJMoa2035807.
Ref 7 Phase III, randomized trial of mirvetuximab soravtansine versus chemotherapy in patients with platinum-resistant ovarian cancer: primaryanalysis of FORWARD I. Ann Oncol. 2021 Jun;32(6):757-765.
Ref 8 Polatuzumab vedotin plus bendamustine and rituximab in relapsed/refractory DLBCL: survival update and new extension cohort data. Blood Adv. 2022 Jan 25;6(2):533-543.
Ref 9 Phase Ib Study of Telisotuzumab Vedotin in Combination With Erlotinib in Patients With c-Met Protein-Expressing Non-Small-Cell Lung Cancer. J Clin Oncol. 2023 Feb 10;41(5):1105-1115.
Ref 10 Tisotumab Vedotin-tftv. Am J Health Syst Pharm. 2022 Jan 24;79(3):120-122. doi: 10.1093/ajhp/zxab418.
Ref 11 Phase Ib study of pembrolizumab in combination with trastuzumab emtansine for metastatic HER2-positive breast cancer. J Immunother Cancer. 2022 Oct;10(10):e005119.
Ref 12 Safety, Tolerability, Pharmacokinetics, and Preliminary Efficacy, Phase 1 Study of CMG901; NCT04805307.
Ref 13 An Innovative Site-Specific Anti-HER2 Antibody-Drug Conjugate with High Homogeneity and Improved Therapeutic Index. Onco Targets Ther. 2022 Apr 8;15:331-343.
Ref 14 Introduction to basic information on recombinant anti-HER2 humanized monoclonal antibody-DM1(Qilu Pharmaceutical Co., Ltd.).
Ref 15 Study of Turning Point Therapeutics LM-302 in Patients With Advance Solid Tumors; NCT05001516.
Ref 16 A phase 1 study of SGN-B6A, an antibody-drug conjugate targeting integrin beta-6, in patients with advanced solid tumors (SGNB6A-001, Trial in Progress). Journal of Clinical Oncology 2021 39:15_suppl, TPS3144-TPS3144.
Ref 17 Phase 1 study of SGN-PDL1V, a novel, investigational vedotin antibodydrug conjugate directed to PD-L1, in patients with advanced solid tumors (SGNPDL1V-001, trial in progress). Journal of Clinical Oncology 2022 40:16_suppl, TPS3154-TPS3154.
Ref 18 Open-label, Phase 2 Study, Evaluating the Efficacy and Safety of Tusamitamab Ravtansine in Non-squamous Non-small-cell Lung Cancer (NSQ NSCLC) Participants With Negative or Moderate CEACAM5 Expression Tumors and High Circulating CEA, NCT05245071
Ref 19 The Dolaflexin-based Antibody-Drug Conjugate XMT-1536 Targets the Solid Tumor Lineage Antigen SLC34A2/NaPi2b. Mol Cancer Ther. 2021 May;20(5):896-905.
Ref 20 Safety, tolerability, and pharmacokinetics of BAT8001 in patients with HER2-positive breast cancer: An open-label, dose-escalation, phase I study. Cancer Commun (Lond). 2021 Feb;41(2):171-182.
Ref 21 TAA013 a trastuzumab antibody drug conjugate phase I dose escalation study in recurrent her2 positive breast cancer. Cancer Res (2021) 81 (4_Supplement): PS10-51.
Ref 22 REFRaME-O1: A Study to Investigate the Efficacy and Safety of Luveltamab Tazevibulin in Women With Ovarian Cancer (Including Fallopian Tube or Primary Peritoneal Cancers) Expressing FOLR1
Ref 23 Phase I Trial of a Novel Anti-HER2 Antibody-Drug Conjugate, ARX788, for the Treatment of HER2-Positive Metastatic Breast Cancer. Clin Cancer Res. 2022 Jun 29:OF1-OF10.
Ref 24 Preclinical development of BB-1701, a HER2-tageting eribulin-containing ADC with potent bystander effect and ICD activity. Cancer Res (2023) 83 (7_Supplement): 1887.
Ref 25 Clinical perspective: Antibody-drug conjugates for the treatment of HER2-positive breast cancer. Mol Ther. 2023 Mar 22:S1525-0016(23)00140-5. doi: 10.1016/j.ymthe.2023.03.019.
Ref 26 FOR46 in Combination With Enzalutamide in Patients With Metastatic Castration Resistant Prostate Cancer; NCT05011188.
Ref 27 Ladiratuzumab vedotin for metastatic triple negative cancer: preliminary results, key challenges, and clinical potential. Expert Opin Investig Drugs. 2022 Jun;31(6):495-498. doi: 10.1080/13543784.2022.2042252.
Ref 28 A Dose Escalation Phase Ia Study of Anti-CD20 Antibody Drug Conjugate, MRG001 in Relapsed/Refractory Advanced Non-Hodgkin Lymphom. Blood. 2021 ;138():-. doi: 10.1182/blood-2021-144829.
Ref 29 Preclinical evaluation of MRG002, a novel HER2-targeting antibody-drug conjugate with potent antitumor activity against HER2-positive solid tumors. Antib Ther. 2021 Aug 28;4(3):175-184.
Ref 30 A phase 2 open-label study of conditionally active biologic ozuriftamab vedotin (BA3021) in failed PD-1/L1 treatment of patients with recurrent or metastatic squamous cell carcinoma of the head and neck. Journal of Clinical Oncology 2023 41:16_suppl, TPS6107-TPS6107.
Ref 31 Praluzatamab Ravtansine, a CD166-Targeting Antibody-Drug Conjugate, in Patients with Advanced Solid Tumors: An Open-Label Phase I/II Trial. Clin Cancer Res. 2022 May 13;28(10):2020-2029.
Ref 32 A Study of RC108-ADC in subjects with advanced digestive system malignant tumor.
Ref 33 Hengrui R&D pipeline.
Ref 34 Zilovertamab Vedotin Targeting of ROR1 as Therapy for Lymphoid Cancers. NEJM Evidence. 2021;1(1). doi: DOI: 10.1056/EVIDoa2100001.
Ref 35 A Randomized Phase II Study of AGS-16C3F Versus Axitinib in Previously Treated Patients with Metastatic Renal Cell Carcinoma. Oncologist. 2021 Mar;26(3):182-e361.
Ref 36 Anetumab ravtansine versus vinorelbine in patients with relapsed, mesothelin-positive malignant pleural mesothelioma (ARCS-M): a randomised, open-label phase 2 trial. Lancet Oncol. 2022 Apr;23(4):540-552.
Ref 37 A phase I study of a CanAg-targeted immunoconjugate, huC242-DM4, in patients with Can Ag-expressing solid tumors. Journal of Clinical Oncology 25, no. 18_suppl (June 20, 2007) 3062-3062.
Ref 38 A phase 2 study of glembatumumab vedotin, an antibody-drug conjugate targeting glycoprotein NMB, in patients with advanced melanoma. Cancer. 2019 Apr 1;125(7):1113-1123.
Ref 39 A phase II, single-arm, multicentre study of coltuximab ravtansine (SAR3419) and rituximab in patients with relapsed or refractory diffuse large B-cell lymphoma. Br J Haematol. 2016 Jun;173(5):722-30. doi: 10.1111/bjh.13992.
Ref 40 A phase II study of antibody-drug conjugate, TAK-264 (MLN0264) in previously treated patients with advanced or metastatic pancreatic adenocarcinoma expressing guanylyl cyclase C. Invest New Drugs. 2017 Oct;35(5):634-641.
Ref 41 Phase Ia Study of Anti-NaPi2b Antibody-Drug Conjugate Lifastuzumab Vedotin DNIB0600A in Patients with Non-Small Cell Lung Cancer and Platinum-Resistant Ovarian Cancer. Clin Cancer Res. 2020 Jan 15;26(2):364-372.
Ref 42 ADVL1522: A phase 2 study of lorvotuzumab mertansine (IMGN901) in children with relapsed or refractory wilms tumor, rhabdomyosarcoma, neuroblastoma, pleuropulmonary blastoma, malignant peripheral nerve sheath tumor, or synovial sarcoma-A Children's Oncology Group study. Cancer. 2020 Dec 15;126(24):5303-5310. doi: 10.1002/cncr.33195. Epub 2020 Sep 11.
Ref 43 Safety and Efficacy of CD37-Targeting Naratuximab Emtansine PLUS Rituximab in Diffuse Large B-Cell Lymphoma and Other NON-Hodgkin'S B-Cell Lymphomas - a Phase 2 Study. Blood (2021) 138 (Supplement 1): 526.
Ref 44 Antibody-drug conjugates targeting prostate-specific membrane antigen. Front Biosci (Landmark Ed). 2014 Jan 1;19(1):12-33. doi: 10.2741/4193.
Ref 45 An Antibody-Drug Conjugate Targeting MUC1-Associated Carbohydrate CA6 Shows Promising Antitumor Activities. Mol Cancer Ther. 2020 Aug;19(8):1660-1669.
Ref 46 Preclinical Evaluation of 9MW2821, a Site-Specific Monomethyl Auristatin E-based Antibody-Drug Conjugate for treatment of Nectin-4-expressing Cancers. Mol Cancer Ther 2023 May MCT-22-0743.
Ref 47 A First-in-human of Multiplle Doses of BB-1705 in Subjects With Locally Advanced/Metastatic Solid Tumors; NCT05217693.
Ref 48 A Study in Patients With Advanced Cancers; NCT05320588.
Ref 49 Antibody-drug conjugation SYS6002 receives clinical trial approval; 27 Oct 2022.
Ref 50 Phase I, First-in-Human Study of the Probody Therapeutic CX-2029 in Adults with Advanced Solid Tumor Malignancies. Clin Cancer Res. 2021 Aug 15;27(16):4521-4530.
Ref 51 First-in-Human Phase 1 Study of MORAb-202, an Antibody-Drug Conjugate Comprising Farletuzumab Linked to Eribulin Mesylate, in Patients with Folate Receptor--Positive Advanced Solid Tumors. Clin Cancer Res. 2021 Jul 15;27(14):3905-3915. doi: 10.1158/1078-0432.CCR-20-4740.
Ref 52 Innolake biopharm biotechnology company product pipeline
Ref 53 IMGC936, an investigational ADAM9-targeting antibody drug conjugate, is active against patient-derived ADAM9-expressing xenograft models. Cancer Res (2021) 81 (13_Supplement): 1841.
Ref 54 Salubris biotherapeutics announces $35 million financing to advance development activities and provides pipeline updates; 28 Mar 2023.
Ref 55 Legochem biosciences biopharmaceutical company product pipeline
Ref 56 Preclinical activity of LM-305 targeting G-protein-coupled receptor class 5 member D (GPRC5D) antibody drug conjugate for the treatment of multiple myeloma. Cancer Res (2022) 82 (12_Supplement): 6020.
Ref 57 ADC review: basic information about Mecbotamab vedotin.
Ref 58 A Study of MRG004A in Patients With Tissue Factor Positive Advanced or Metastatic Solid Tumors; NCT04843709.
Ref 59 Introduction to basic information on ADC drug RC118.
Ref 60 Preclinical safety profile of RC88-ADCa novel mesothelin-targeted antibody conjugated with Monomethyl auristatin E. Drug Chem Toxicol. 2023 Jan;46(1):24-34. doi: 10.1080/01480545.2021.2005085. Epub 2021 Nov 28.
Ref 61 A phase 1/2 study of REGN5093-M114, a METxMET antibody-drug conjugate, in patients with mesenchymal epithelial transition factor (MET)-overexpressing NSCLC. Journal of Clinical Oncology 2022 40:16_suppl, TPS8593-TPS8593.
Ref 62 AVID100 is an anti-EGFR ADC that promotes DM1-meditated cytotoxicity on cancer cells but not on normal cells. Cancer Res (2019) 79 (13_Supplement): 218. doi: 10.1158/1538-7445.AM2019-218.
Ref 63 Phase I/IIa Trial of BMS-986148, an Anti-mesothelin Antibody-drug Conjugate, Alone or in Combination with Nivolumab in Patients with Advanced Solid Tumors. Clin Cancer Res. 2022 Jan 1;28(1):95-105.
Ref 64 Safety and efficacy of depatuxizumab mafodotin in Japanese patients with malignant glioma: A nonrandomized, phase 1/2 trial. Cancer Sci. 2021 Dec;112(12):5020-5033. doi: 10.1111/cas.15153. Epub 2021 Oct 30.
Ref 65 Enapotamab Vedotin, an AXL-Specific Antibody-Drug Conjugate, Demonstrates Antitumor Efficacy in Patient-Derived Xenograft Models of Soft Tissue Sarcoma. Int J Mol Sci. 2022 Jul 6;23(14):7493. doi: 10.3390/ijms23147493.
Ref 66 Indatuximab Ravtansine (BT062) Monotherapy in Patients With Relapsed and/or Refractory Multiple Myeloma. Clin Lymphoma Myeloma Leuk. 2019 Jun;19(6):372-380.
Ref 67 Efficacy of the Antibody-Drug Conjugate W0101 in Preclinical Models of IGF-1 Receptor Overexpressing Solid Tumors. Mol Cancer Ther. 2020 Jan;19(1):168-177.
Ref 68 First-in-Human, Phase 1 Dose-Escalation Study of Biparatopic Anti-HER2 Antibody-Drug Conjugate MEDI4276 in Patients with HER2-positive Advanced Breast or Gastric Cancer. Mol Cancer Ther. 2021 Aug;20(8):1442-1453.
Ref 69 Phase 1/2 multiple ascending dose trial of the prostate-specific membrane antigen-targeted antibody drug conjugate MLN2704 in metastatic castration-resistant prostate cancer. Urol Oncol. 2016 Dec;34(12):530.e15-530.e21.
Ref 70 Preclinical Studies of OBI-999: A Novel Globo H-Targeting Antibody-Drug Conjugate. Mol Cancer Ther. 2021 Jun;20(6):1121-1132.
Ref 71 Preclinical development and characterization of STI-6129, an anti-CD38 antibody-drug conjugate, as a new therapeutic agent for multiple myeloma. Cancer Res (2020) 80 (16_Supplement): LB-227.
Ref 72 Preclinical studies targeting CD74 with STRO-001 antibody-drug conjugate in acute leukemia. Blood Adv (2023) 7 (9): 16661670.
Ref 73 Introduction to basic information on ADC drug AB-160.
Ref 74 Adcentrx therapeutics product pipeline
Ref 75 Angiex biotechnology company product pipeline.
Ref 76 AMT-151 in Patients With Selected Advanced Solid Tumours; NCT05498597.
Ref 77 Ambrx biopharmaceutical company product pipeline.
Ref 78 Preclinical characterization of ARX517, a next-generation anti-PSMA antibody drug conjugate for the treatment of metastatic castration-resistant prostate cancer. Cancer Res (2023) 83 (7_Supplement): 3997.
Ref 79 ASN004, A 5T4-targeting scFv-Fc Antibody-Drug Conjugate with High Drug-to-Antibody Ratio, Induces Complete and Durable Tumor Regressions in Preclinical Models. Mol Cancer Ther. 2021 Aug;20(8):1327-1337.
Ref 80 A Study of ATG-022 in Patients With Advanced/Metastatic Solid Tumors (CLINCH); NCT05718895.
Ref 81 Phase I Clinical Trial on the Safety, Tolerability, Pharmacokinetics of B003 in the Treatment of HER2-positive Recurrent or Metastatic Breast Cancer, NCT03953833
Ref 82 Boan biotechnology company product pipeline
Ref 83 BB-1709 for injection was approved for clinical practice; 29 Jan 2023.
Ref 84 BC3195: world's first next-generation antibody-coupled drug (ADC) targeting CDH3 approved for US clinical trials.
Ref 85 Bioray pharmaceutical company product pipeline
Ref 86 DAC biotechnology company product pipeline
Ref 87 First made-in-Singapore antibody-drug conjugate (ADC) approved to enter clinical trials; 4 Jan 2023.
Ref 88 Conjugation of DM1 to anti-CD30 antibody has potential antitumor activity in CD30-positive hematological malignancies with lower systemic toxicity. MAbs. 2019 Aug/Sep;11(6):1149-1161. doi: 10.1080/19420862.2019.1618674. Epub 2019 Jun 4.
Ref 89 GQ1001 is a next generation HER2-targeting ADC with excellent druggability, safety and potency. Cancer Res (2023) 83 (7_Supplement): 2702. doi: 10.1158/1538-7445.AM2023-2702.
Ref 90 IMGN151-A next generation folate receptor alpha targeting antibody drug conjugate active against tumors with low, medium and high receptor expression. Cancer Res (2020) 80 (16_Supplement): 2890.
Ref 91 A Clinical Study to Evaluate the Safety and Tolerability of JS107 in Advanced or Metastatic Solid Tumors; NCT05502393.
Ref 92 Sihuan pharmaceutical's first class 1 macromolecule innovative drug HER2 bispecific antibody adc XZP-KM501 approved for clinical trials; 24 Mar 2023.
Ref 93 M1231 is a bispecific anti-MUC1xEGFR antibody-drug conjugate designed to treat solid tumors with MUC1 and EGFR co-expression. Cancer Res (2022) 82 (12_Supplement): 5284.
Ref 94 Targeting CD205 with the antibody drug conjugate MEN1309/OBT076 is an active new therapeutic strategy in lymphoma models. Haematologica. 2020 Nov 1;105(11):2584-2591.
Ref 95 MYTX-011: A novel cMET-targeting antibody drug conjugate (ADC) engineered to increase on-target uptake in and efficacy against cMET expressing tumors. Cancer Res (2023) 83 (7_Supplement): 5000.
Ref 96 NewBio Therapeutics company product pipeline
Ref 97 An optimized preclinical antibody-drug conjugate against cancers with cKIT overexpression or activating mutations. Cancer Res (2022) 82 (12_Supplement): 6227.
Ref 98 OMTX705, a Novel FAP-Targeting ADC Demonstrates Activity in Chemotherapy and Pembrolizumab-Resistant Solid Tumor Models. Clin Cancer Res. 2020 Jul 1;26(13):3420-3430.
Ref 99 Study of PYX-201 in Solid Tumors; NCT05720117.
Ref 100 GN-B7H4V, a novel, investigational vedotin antibody-drug conjugate directed to the T cell checkpoint ligand B7-H4, shows promising activity in preclinical models. Journal for ImmunoTherapy of Cancer 2021;9:doi: 10.1136/jitc-2021-SITC2021.854.
Ref 101 Xiling yuan pharmaceutical company product pipeline
Ref 102 TORL BioTherapeutics raises funds to develop new oncology therapies; 14 Apr 2023.
Ref 103 First in Human Study of TORL-3-600 in Participants With Advanced Cancer.
Ref 104 First in Human Study of TORL-4-500 in Participants With Advanced Cancer.
Ref 105 A phase 1 study of TRS005 in patients with R/R CD20-positive B-NHL.
Ref 106 Exelixis biotechnology company product pipeline
Ref 107 Discovery and Preclinical Characterization of XMT-1660, an Optimized B7-H4-Targeted Antibody-Drug Conjugate for the Treatment of Cancer. Mol Cancer Ther. 2023 Jun 9:MCT-22-0786. doi: 10.1158/1535-7163.MCT-22-0786.
Ref 108 Study of ZV0203 in Patients With HER2-Positive Advanced Solid Tumors; NCT05423977.
Ref 109 Phase Ia, first-in-human study of AbGn-107, a novel antibody-drug conjugate (ADC), in patients with gastric, colorectal, pancreatic, or biliary cancers. Journal of Clinical Oncology 2020 38:4_suppl, 713-713.
Ref 110 Anti-tumor effect of antibody drug conjugate ASP1235 targeting Fms-like tyrosine kinase 3 with venetoclax plus azacitidine in an acute myeloid leukemia xenograft mouse model. Oncotarget. 2022 Dec 20;13:1359-1368.
Ref 111 AGS67E, an Anti-CD37 Monomethyl Auristatin E Antibody-Drug Conjugate as a Potential Therapeutic for B/T-Cell Malignancies and AML: A New Role for CD37 in AML. Mol Cancer Ther. 2015 Jul;14(7):1650-60.
Ref 112 First-in-human multicenter phase I study of BMS-936561 (MDX-1203), an antibody-drug conjugate targeting CD70. Cancer Chemother Pharmacol. 2016 Jan;77(1):155-62.
Ref 113 Phase 1 study of the anti-BCMA antibody-drug conjugate AMG 224 in patients with relapsed/refractory multiple myeloma. Leukemia. 2021 Jan;35(1):255-258.
Ref 114 AMG 595, an Anti-EGFRvIII Antibody-Drug Conjugate, Induces Potent Antitumor Activity against EGFRvIII-Expressing Glioblastoma. Mol Cancer Ther. 2015 Jul;14(7):1614-24. doi: 10.1158/1535-7163.MCT-14-1078. Epub 2015 Apr 30.
Ref 115 First-in-Human Phase I Study of Aprutumab Ixadotin, a Fibroblast Growth Factor Receptor 2 Antibody-Drug Conjugate (BAY 1187982) in Patients with Advanced Cancer. Target Oncol. 2019 Oct;14(5):591-601.
Ref 116 The Discovery and Preclinical Development of ASG-5ME, an Antibody-Drug Conjugate Targeting SLC44A4-Positive Epithelial Tumors Including Pancreatic and Prostate Cancer. Mol Cancer Ther. 2016 Nov;15(11):2679-2687. doi: 10.1158/1535-7163.MCT-16-0225. Epub 2016 Aug 22.
Ref 117 Phase I studies of AVE9633, an anti-CD33 antibody-maytansinoid conjugate, in adult patients with relapsed/refractory acute myeloid leukemia. Invest New Drugs. 2012 Jun;30(3):1121-31. doi: 10.1007/s10637-011-9670-0. Epub 2011 Apr 26.
Ref 118 First-in-Human Phase I Study of ABBV-838, an Antibody-Drug Conjugate Targeting SLAMF7/CS1 in Patients with Relapsed and Refractory Multiple Myeloma. Clin Cancer Res. 2020 May 15;26(10):2308-2317.
Ref 119 Development of a potent Trop-2 antibody-drug conjugate, BAT8003, for the treatment of Trop-2 positive gastric tumors. Cancer Res (2019) 79 (13_Supplement): 4821.
Ref 120 ADC review BAY79-4620
Ref 121 An antibody-cytotoxic conjugate, BIIB015, is a new targeted therapy for Cripto positive tumours. Eur J Cancer. 2011 Jul;47(11):1736-46.
Ref 122 Combined treatment of the immunoconjugate bivatuzumab mertansine and fractionated irradiation improves local tumour control in vivo. Radiother Oncol. 2012 Mar;102(3):444-9. doi: 10.1016/j.radonc.2011.10.013. Epub 2011 Nov 17.
Ref 123 Cantuzumab mertansine, a maytansinoid immunoconjugate directed to the CanAg antigen: a phase I, pharmacokinetic, and biologic correlative study. J Clin Oncol. 2003 Jan 15;21(2):211-22.
Ref 124 Safety and efficacy of CDX-014, an antibody-drug conjugate directed against T cell immunoglobulin mucin-1 in advanced renal cell carcinoma. Invest New Drugs. 2020 Dec;38(6):1807-1814.
Ref 125 First-in-Human Study of PF-06647020 (Cofetuzumab Pelidotin), an Antibody-Drug Conjugate Targeting Protein Tyrosine Kinase 7, in Advanced Solid Tumors. Clin Cancer Res. 2021 Aug 15;27(16):4511-4520.
Ref 126 Current Status of Marine-Derived Compounds as Warheads in Anti-Tumor Drug Candidates. Mar Drugs. 2017 Mar 29;15(4):99. doi: 10.3390/md15040099.
Ref 127 Introduction to basic information on ADC drug RG 7598.
Ref 128 Introduction to basic information on ADC drug RG 7841.
Ref 129 Preclinical Efficacy of an Antibody-Drug Conjugate Targeting Mesothelin Correlates with Quantitative 89Zr-ImmunoPET. Mol Cancer Ther. 2017 Jan;16(1):134-142. doi: 10.1158/1535-7163.MCT-16-0449. Epub 2016 Oct 19.
Ref 130 An open-label phase I dose-escalation study of the safety and pharmacokinetics of DMUC4064A in patients with platinum-resistant ovarian cancer. Gynecol Oncol. 2021 Dec;163(3):473-480. doi: 10.1016/j.ygyno.2021.09.023. Epub 2021 Oct 6.
Ref 131 Efficacy and Safety of Patritumab Deruxtecan (HER3-DXd) in EGFR Inhibitor-Resistant, EGFR-Mutated Non-Small Cell Lung Cancer. Cancer Discov. 2022 Jan;12(1):74-89.
Ref 132 Clinical Study of ALT-P7 to Determine Safety, Tolerability and Pharmacokinetics in Breast Cancer Patients; NCT03281824.
Ref 133 A Phase I Study of the Anti-CD79b THIOMABTM-Drug Conjugate DCDS0780A in Patients (pts) with Relapsed or Refractory B-Cell Non-Hodgkin's Lymphoma (B-NHL). Blood. 2017;130(S1): 4129. doi: 10.1182/blood.V130.Suppl_1.4129.4129.
Ref 134 A phase I dose-escalation study of IMGN388 in patients with solid tumors. Journal of Clinical Oncology 28, no. 15_suppl (May 20, 2010) 3058-3058.
Ref 135 A Study of CC-99712, a BCMA Antibody-Drug Conjugate, in Participants With Relapsed and Refractory Multiple Myeloma.
Ref 136 A Novel Antibody-Drug Conjugate Targeting CCR7 in Hematologic Malignancies. Blood (2022) 140 (Supplement 1): 1156411565.
Ref 137 Monoclonal antibody-based therapeutics, targeting the epidermal growth factor receptor family: from herceptin to Pan HER. J Pharm Pharmacol. 2018 Jul;70(7):841-854. doi: 10.1111/jphp.12911. Epub 2018 Mar 25.
Ref 138 Preclinical Antitumor Activity of a Novel Anti-c-KIT Antibody-Drug Conjugate against Mutant and Wild-type c-KIT-Positive Solid Tumors. Clin Cancer Res. 2018 Sep 1;24(17):4297-4308. doi: 10.1158/1078-0432.CCR-17-3795. Epub 2018 May 15.
Ref 139 A phase 1 study evaluating safety and pharmacokinetics of losatuxizumab vedotin (ABBV-221), an anti-EGFR antibody-drug conjugate carrying monomethyl auristatin E, in patients with solid tumors likely to overexpress EGFR. Invest New Drugs. 2020 Oct;38(5):1483-1494.
Ref 140 Preclinical Antitumor Efficacy of BAY 1129980-a Novel Auristatin-Based Anti-C4.4A (LYPD3) Antibody-Drug Conjugate for the Treatment of Non-Small Cell Lung Cancer. Mol Cancer Ther. 2017 May;16(5):893-904. doi: 10.1158/1535-7163.MCT-16-0474. Epub 2017 Mar 14.
Ref 141 A phase 1 study of LY3076226, a fibroblast growth factor receptor 3 (FGFR3) antibody-drug conjugate, in patients with advanced or metastatic cancer. Invest New Drugs. 2021 Dec;39(6):1613-1623. doi: 10.1007/s10637-021-01146-x. Epub 2021 Jul 15.
Ref 142 Phase 1, open-label study of MEDI-547 in patients with relapsed or refractory solid tumors. Invest New Drugs. 2013 Feb;31(1):77-84.
Ref 143 A phase 1 study evaluating the safety, pharmacology and preliminary activity of MM-310 in patients with solid tumors. Journal of Clinical Oncology 2018 36:15_suppl, TPS2604-TPS2604.
Ref 144 PCA062, a P-cadherin Targeting Antibody-Drug Conjugate, Displays Potent Antitumor Activity Against P-cadherin-expressing Malignancies. Mol Cancer Ther. 2021 Jul;20(7):1270-1282. doi: 10.1158/1535-7163.MCT-20-0708. Epub 2021 Apr 20.
Ref 145 First-in-human trial of an anti-5T4 antibody-monomethylauristatin conjugate, PF-06263507, in patients with advanced solid tumors. Invest New Drugs. 2017 Jun;35(3):315-323. doi: 10.1007/s10637-016-0419-7. Epub 2017 Jan 9.
Ref 146 A phase I, dose-escalation study of PF-06650808, an anti-Notch3 antibody-drug conjugate, in patients with breast cancer and other advanced solid tumors. Invest New Drugs. 2020 Feb;38(1):120-130.
Ref 147 A phase 1, dose-escalation study of PF-06664178, an anti-Trop-2/Aur0101 antibody-drug conjugate in patients with advanced or metastatic solid tumors. Invest New Drugs. 2018 Oct;36(5):836-847.
Ref 148 PF-06804103, A Site-specific Anti-HER2 Antibody-Drug Conjugate for the Treatment of HER2-expressing Breast, Gastric, and Lung Cancers. Mol Cancer Ther. 2020 Oct;19(10):2068-2078.
Ref 149 Polatuzumab vedotin or pinatuzumab vedotin plus rituximab in patients with relapsed or refractory non-Hodgkin lymphoma: final results from a phase 2 randomised study (ROMULUS). Lancet Haematol. 2019 May;6(5):e254-e265.
Ref 150 LRRC15 Targeting in Soft-Tissue Sarcomas: Biological and Clinical Implications. Cancers (Basel). 2020 Mar 23;12(3):757.
Ref 151 ADC review SAR428926
Ref 152 SGN-CD48A: a Novel Humanized Anti-CD48 Antibody-Drug Conjugate for the Treatment of Multiple Myeloma. Blood. 2016 ;128(22):-. doi: 10.1182/blood.V128.22.4470.4470.
Ref 153 Phase 1 study of SGN-ALPV, a novel, investigational vedotin antibodydrug conjugate directed to ALPP/ALPPL2 in advanced solid tumors (SGNALPV-001, trial in progress). Journal of Clinical Oncology 2022 40:16_suppl, TPS3159-TPS3159.
Ref 154 Preclinical activity of the antibody-drug conjugate denintuzumab mafodotin (SGN-CD19A) against pediatric acute lymphoblastic leukemia xenografts. Pediatr Blood Cancer. 2019 Aug;66(8):e27765. doi: 10.1002/pbc.27765. Epub 2019 Apr 23.
Ref 155 SGN-CD228A Is an Investigational CD228-Directed Antibody-Drug Conjugate with Potent Antitumor Activity across a Wide Spectrum of Preclinical Solid Tumor Models. Mol Cancer Ther. 2023 Apr 3;22(4):421-434. doi: 10.1158/1535-7163.MCT-22-0401.
Ref 156 Targeting Sialyl-Thomsen nouveau (STn) antigen with the SGN-STNV antibody-drug conjugate is effective in preclinical studies. Cancer Res (2021) 81 (13_Supplement): 50. doi: 10.1158/1538-7445.AM2021-50.
Ref 157 Safety, tolerability, pharmacokinetics and immunogenicity of an antibody-drug conjugate (SHR-A1201) in patients with HER2-positive advanced breast cancer: an open, phase I dose-escalation study. Anticancer Drugs. 2023 Jul 1;34(6):763-774.
Ref 158 SHR-A1403, a novel c-Met antibody-drug conjugate, exerts encouraging anti-tumor activity in c-Met-overexpressing models. Acta Pharmacol Sin. 2019 Jul;40(7):971-979.
Ref 159 ADC review: basic information about sirtratumab vedotin.
Ref 160 Phase I study of safety and pharmacokinetics of the anti-MUC16 antibody-drug conjugate DMUC5754A in patients with platinum-resistant ovarian cancer or unresectable pancreatic cancer. Ann Oncol. 2016 Nov;27(11):2124-2130. doi: 10.1093/annonc/mdw401.
Ref 161 Therapeutic potential of EO-3021/SYSA1801, a Claudin18.2 antibody-drug conjugate, for the treatment of CLDN18.2-expressing cancers. Cancer Res (2023) 83 (7_Supplement): 6300.
Ref 162 A Phase I Pharmacokinetic (PK) and Safety Study of Trph-222 in Patients with Relapsed/Refractory B-Cell Non-Hodgkin Lymphoma (R/R NHL): Dose-Escalation Results. Blood 2020 Nov 5; 136(1): 41-42.
Ref 163 Introduction to basic information on ADC drug vandortuzumab vedotin.
Ref 164 Phase I dose-escalation study of SGN-75 in patients with CD70-positive relapsed/refractory non-Hodgkin lymphoma or metastatic renal cell carcinoma. Invest New Drugs. 2014 Dec;32(6):1246-57. doi: 10.1007/s10637-014-0151-0. Epub 2014 Aug 22.
Ref 165 A first-in-human phase 1 study of the safety and pharmacokinetics of XB002 in patients with inoperable locally advanced or metastatic solid tumors. Cancer Res (2022) 82 (12_Supplement): CT254.
Ref 166 Non-clinical pharmacokinetics of XMT-1522, a HER2 targeting auristatin-based antibody drug conjugate. Cancer Res (2017) 77 (13_Supplement): 48.
Ref 167 XMT-1592, a site-specific Dolasynthen-based NaPi2b-targeted antibody-drug conjugate for the treatment of ovarian cancer and lung adenocarcinoma. Cancer Res (2020) 80 (16_Supplement): 2894.
Ref 168 Zanidatamab zovodotin (ZW49) induces hallmarks of immunogenic cell death and is active in patient-derived xenograft models of gastric cancer. Cancer Res (2023) 83 (7_Supplement): 2633.
Ref 169 Characterization of Site-Specifically Conjugated Monomethyl Auristatin E- and Duocarmycin-Based Anti-PSMA Antibody-Drug Conjugates for Treatment of PSMA-Expressing Tumors. J Nucl Med. 2018 Mar;59(3):494-501. doi: 10.2967/jnumed.117.196279. Epub 2017 Nov 16.
Ref 170 Aryl Sulfate is a Useful Motif for Conjugating and Releasing Phenolic Molecules: Sulfur Fluorine Exchange Click Chemistry Enables Discovery of Ortho-Hydroxy-Protected Aryl Sulfate Linker. Bioconjug Chem. 2019 Jul 17;30(7):1957-1968. doi: 10.1021/acs.bioconjchem.9b00340. Epub 2019 Jun 28.
Ref 171 MAbs. 2023 Jan-Dec;15(1):2149057. doi: 10.1080/19420862.2022.2149057.
Ref 172 Anti-integrin immunoconjugates, methods and uses; 2008-01-17.
Ref 173 Anti-cxcr4 antibodies and antibody-drug conjugates.
Ref 174 Development of applicable thiol-linked antibody-drug conjugates with improved stability and therapeutic index. Drug Deliv. 2022 Dec;29(1):754-766.
Ref 175 Anti-CDCP1 immuno-conjugates for detection and inhibition of ovarian cancer. Theranostics. 2020 Jan 12;10(5):2095-2114. doi: 10.7150/thno.30736. eCollection 2020.
Ref 176 An auristatin-based peptide-drug conjugate targeting Kita-Kyushu lung cancer antigen 1 for precision chemoradiotherapy in gastric cancer. Eur J Med Chem. 2022 Nov 5;241:114617.
Ref 177 Site-specific antibody-drug conjugation through glycoengineering.
Ref 178 Click Chemistry-Generated Auristatin F-Linker-Benzylguanine for a SNAP-Tag-Based Recombinant Antibody-Drug Conjugate Demonstrating Selective Cytotoxicity toward EGFR-Overexpressing Tumor Cells. ACS Omega. 2023 Jan 17;8(4):4026-4037. doi: 10.1021/acsomega.2c06844. eCollection 2023 Jan 31.
Ref 179 Extracellular LGALS3BP: a potential disease marker and actionable target for antibody-drug conjugate therapy in glioblastoma. Mol Oncol. 2023 Aug;17(8):1460-1473. doi: 10.1002/1878-0261.13453. Epub 2023 Jun 7.
Ref 180 Targeting Vesicular LGALS3BP by an Antibody-Drug Conjugate as Novel Therapeutic Strategy for Neuroblastoma. Cancers (Basel). 2020 Oct 15;12(10):2989. doi: 10.3390/cancers12102989.
Ref 181 Introduction to basic information on ADC drug 1C1-mcMMAF
Ref 182 Novel peptide linkers for highly potent antibody-auristatin conjugate. Bioconjug Chem. 2008 Oct;19(10):1960-3. doi: 10.1021/bc800289a. Epub 2008 Sep 20.
Ref 183 Treating Tissue Factor-Positive Cancers with Antibody-Drug Conjugates That Do Not Affect Blood Clotting. Mol Cancer Ther. 2018 Nov;17(11):2412-2426.
Ref 184 CA6 antigen-specific cytotoxic conjugate and methods of using the same; 2017-11-21.
Ref 185 Antibody-Drug Conjugates Targeting the Urokinase Receptor (uPAR) as a Possible Treatment of Aggressive Breast Cancer. Antibodies (Basel). 2019 Nov 5;8(4):54. doi: 10.3390/antib8040054.
Ref 186 Antibody-immunotoxin Conjugate Using FcBP-mediated Photoconjugation to Treat Cancer. Anticancer Res. 2022 Jul;42(7):3453-3461. doi: 10.21873/anticanres.15832.
Ref 187 Cysteine engineered antibodies and conjugates.
Ref 188 Identification of Prostaglandin F2 Receptor Negative Regulator (PTGFRN) as an internalizable target in cancer cells for antibody-drug conjugate development. PLoS One. 2021 Jan 27;16(1):e0246197. doi: 10.1371/journal.pone.0246197. eCollection 2021.
Ref 189 Antibody drug conjugates of cleavable amino-benzoyl-maytansinoids. Bioorg Med Chem. 2020 Dec 1;28(23):115785. doi: 10.1016/j.bmc.2020.115785. Epub 2020 Oct 11.
Ref 190 Antibody drug conjugates, targeting cancer-expressed EGFR, exhibit potent and specific antitumor activity. Biomed Pharmacother. 2023 Jan;157:114047.
Ref 191 Antibody-Drug Conjugate Targeting c-Kit for the Treatment of Small Cell Lung Cancer. Int J Mol Sci. 2022 Feb 18;23(4):2264.
Ref 192 Genetically Encoded Azide Containing Amino Acid in Mammalian Cells Enables Site-Specific Antibody-Drug Conjugates Using Click Cycloaddition Chemistry. Bioconjug Chem. 2015 Nov 18;26(11):2249-60. doi: 10.1021/acs.bioconjchem.5b00359.
Ref 193 Unbiased cell surface proteomics identifies SEMA4A as an effective immunotherapy target for myeloma. Blood. 2022 Apr 21;139(16):2471-2482. doi: 10.1182/blood.2021015161.
Ref 194 Targeting a Radiosensitizing Antibody-Drug Conjugate to a Radiation-Inducible Antigen. Clin Cancer Res. 2021 Jun 1;27(11):3224-3233. doi: 10.1158/1078-0432.CCR-20-1725.
Ref 195 Endo180 (MRC2) Antibody-Drug Conjugate for the Treatment of Sarcoma. Mol Cancer Ther. 2023 Feb 1;22(2):240-253. doi: 10.1158/1535-7163.MCT-22-0312.
Ref 196 Immunoregulation by IL-7R-targeting antibody-drug conjugates: overcoming steroid-resistance in cancer and autoimmune disease. Sci Rep. 2017 Sep 6;7(1):10735. doi: 10.1038/s41598-017-11255-4.
Ref 197 Anti-c-met antibody-drug conjugate and applications thereof; 2022-03-10.
Ref 198 Anti-egfr antibodies and antibody drug conjugates.
Ref 199 AB-3A4: A novel KAAG1-targeting antibody-drug conjugate is active in models of ovarian carcinoma, triple-negative breast cancer and castration-resistant prostate cancer. Cancer Res (2014) 74 (19_Supplement): 666.
Ref 200 Covalent linkers in antibody-drug conjugates and methods of making and using the same.
Ref 201 Targeting HER2 Expressing Tumors with a Potent Drug Conjugate Based on an Albumin Binding Domain-Derived Affinity Protein. Pharmaceutics. 2021 Nov 3;13(11):1847.
Ref 202 Novel Silyl Ether-Based Acid-Cleavable Antibody-MMAE Conjugates with Appropriate Stability and Efficacy. Cancers (Basel). 2019 Jul 8;11(7):957. doi: 10.3390/cancers11070957.
Ref 203 Antibody-drug conjugates with dual payloads for combating breast tumor heterogeneity and drug resistance. Nat Commun. 2021 Jun 10;12(1):3528.
Ref 204 Generation of DAR1 Antibody-Drug Conjugates for Ultrapotent Payloads Using Tailored GlycoConnect Technology. Bioconjug Chem. 2023 Mar 15;34(3):538-548. doi: 10.1021/acs.bioconjchem.2c00611. Epub 2023 Mar 1.
Ref 205 Compositions and methods related to anti-egfr antibody drug conjugates; 2017-03-30.
Ref 206 Avibodie are engineered, bivalent antibody fragments, precisely loaded with imaging or cytotoxic payloads
Ref 207 Adcitmer , a new CD56-targeting monomethyl auristatin E-conjugated antibody, is a potential therapeutic approach in Merkel cell carcinoma. Br J Dermatol. 2022 Feb;186(2):295-306. doi: 10.1111/bjd.20770.
Ref 208 Compositions and methods related to anti-cd19 antibody drug conjugates; 2017-03-30.
Ref 209 Novel antibody drug conjugate to inhibit mesothelioma tumor growth. Cancer Res (2019) 79 (13_Supplement): 210.
Ref 210 Eradicating mesothelin-positive human gastric and pancreatic tumors in xenograft models with optimized anti-mesothelin antibody-drug conjugates from synthetic antibody libraries. Sci Rep. 2021 Jul 29;11(1):15430. doi: 10.1038/s41598-021-94902-1.
Ref 211 Radiation Cleaved Drug-Conjugate Linkers Enable Local Payload Release. Bioconjug Chem. 2022 Aug 17;33(8):1474-1484.
Ref 212 Glucuronide-Linked Antibody-Tubulysin Conjugates Display Activity in MDR(+) and Heterogeneous Tumor Models. Mol Cancer Ther. 2018 Aug;17(8):1752-1760. doi: 10.1158/1535-7163.MCT-18-0073. Epub 2018 Jun 4.
Ref 213 Targeting CLDN18.2 by CD3 Bispecific and ADC Modalities for the Treatments of Gastric and Pancreatic Cancer. Sci Rep. 2019 Jun 10;9(1):8420. doi: 10.1038/s41598-019-44874-0.
Ref 214 Utilization of the Angiopep platform to enable brain penetration of therapeutic mAbs or Antibody-Drug Conjugates for treatment of brain tumors. Cancer Res (2014) 74 (19_Supplement): 2657.
Ref 215 Integrin 10, a Novel Therapeutic Target in Glioblastoma, Regulates Cell Migration, Proliferation, and Survival. Cancers (Basel). 2019 Apr 25;11(4):587. doi: 10.3390/cancers11040587.
Ref 216 Bcma monoclonal antibody-drug conjugate.
Ref 217 Decoupling stability and release in disulfide bonds with antibody-small molecule conjugates. Chem Sci. 2017 Jan 1;8(1):366-370. doi: 10.1039/c6sc01831a. Epub 2016 Aug 22.
Ref 218 Antitumor activity of anti-CD30 immunotoxin (Ber-H2/saporin) in vitro and in severe combined immunodeficiency disease mice xenografted with human CD30+ anaplastic large-cell lymphoma. Blood. 1995 Apr 15;85(8):2139-46.
Ref 219 Therapy of human T-cell acute lymphoblastic leukaemia with a combination of anti-CD7 and anti-CD38-SAPORIN immunotoxins is significantly better than therapy with each individual immunotoxin. Br J Cancer. 2001 Feb;84(4):571-8. doi: 10.1054/bjoc.2000.1633.
Ref 220 Anti-CD47 Monoclonal Antibody-Drug Conjugate: A Targeted Therapy to Treat Triple-Negative Breast Cancers. Vaccines (Basel). 2021 Aug 10;9(8):882. doi: 10.3390/vaccines9080882.
Ref 221 An antibody-drug conjugate with intracellular drug release properties showing specific cytotoxicity against CD7-positive cells. Leuk Res. 2021 Sep;108:106626. doi: 10.1016/j.leukres.2021.106626.
Ref 222 Optimal design, anti-tumour efficacy and tolerability of anti-CXCR4 antibody drug conjugates. Sci Rep. 2019 Feb 21;9(1):2443. doi: 10.1038/s41598-019-38745-x.
Ref 223 DOG1 as a novel antibody-drug conjugate target for the treatment of multiple gastrointestinal tumors and liver metastasis. Front Immunol. 2023 Jan 26;14:1051506. doi: 10.3389/fimmu.2023.1051506. eCollection 2023.
Ref 224 Therapeutic potential of nimotuzumab PEGylated-maytansine antibody drug conjugates against EGFR positive xenograft. Oncotarget. 2019 Feb 1;10(10):1031-1044. doi: 10.18632/oncotarget.26613. eCollection 2019 Feb 1.
Ref 225 Anti-EGFR antibody-drug conjugate for triple-negative breast cancer therapy. Eng Life Sci. 2020 Oct 7;21(1-2):37-44. doi: 10.1002/elsc.202000027. eCollection 2021 Jan.
Ref 226 Anti-Endosialin Antibody-Drug Conjugate: Potential in Sarcoma and Other Malignancies. Mol Cancer Ther. 2015 Sep;14(9):2081-9. doi: 10.1158/1535-7163.MCT-15-0312. Epub 2015 Jul 16.
Ref 227 FcRL5 as a target of antibody-drug conjugates for the treatment of multiple myeloma. Mol Cancer Ther. 2012 Oct;11(10):2222-32. doi: 10.1158/1535-7163.MCT-12-0087. Epub 2012 Jul 17.
Ref 228 FcRL5 as a target of antibody-drug conjugates for the treatment of multiple myeloma. Mol Cancer Ther. 2012 Oct;11(10):2222-32. doi: 10.1158/1535-7163.MCT-12-0087. Epub 2012 Jul 17.
Ref 229 Antibody drug conjugates.
Ref 230 Spirea secures more capital to develop nextgeneration ADC cancer therapeutics; 2020
Ref 231 Sculpting a Uniquely Reactive Cysteine Residue for Site-Specific Antibody Conjugation. Bioconjug Chem. 2022 Jun 15;33(6):1192-1200.
Ref 232 Application of a Biocatalytic Strategy for the Preparation of Tiancimycin-Based Antibody-Drug Conjugates Revealing Key Insights into Structure-Activity Relationships. J Med Chem. 2023 Jan 26;66(2):1562-1573. doi: 10.1021/acs.jmedchem.2c01771.
Ref 233 Stable and Potent Selenomab-Drug Conjugates. Cell Chem Biol. 2017 Apr 20;24(4):433-442.e6. doi: 10.1016/j.chembiol.2017.02.012.
Ref 234 ICOS is widely expressed in cutaneous T-cell lymphoma, and its targeting promotes potent killing of malignant cells. Blood Adv. 2020 Oct 27;4(20):5203-5214. doi: 10.1182/bloodadvances.2020002395.
Ref 235 Targeting and pharmacology of an anti-IL13R2 antibody and antibody-drug conjugate in a melanoma xenograft model. MAbs. 2021 Jan-Dec;13(1):1958662.
Ref 236 Antibody drug conjugates.
Ref 237 NOTCH3-targeted antibody drug conjugates regress tumors by inducing apoptosis in receptor cells and through transendocytosis into ligand cells. Cell Rep Med. 2021 May 18;2(5):100279. doi: 10.1016/j.xcrm.2021.100279. eCollection 2021 May 18.
Ref 238 Anti-NaPi2b antibody-drug conjugate lifastuzumab vedotin (DNIB0600A) compared with pegylated liposomal doxorubicin in patients with platinum-resistant ovarian cancer in a randomized, open-label, phase II study. Ann Oncol. 2018 Apr 1;29(4):917-923.
Ref 239 High-throughput membrane-anchored proteome screening reveals PIEZO1 as a promising antibody-drug target for human esophageal squamous cell carcinoma. Cancer Med. 2022 Oct;11(19):3700-3713.
Ref 240 Antibody-Drug Conjugate to Treat Meningiomas. Pharmaceuticals (Basel). 2021 May 2;14(5):427. doi: 10.3390/ph14050427.
Ref 241 A new immunochemical strategy for triple-negative breast cancer therapy. Sci Rep. 2021 Jul 21;11(1):14875.
Ref 242 Aphios biotechnology company product pipeline
Ref 243 Bispecific HER2 ADC: Making more potent HER2 ADC by improving target internalization; Cancer Res (2019) 79 (13_Supplement): 233..
Ref 244 Novel peptide linker-based nectin-4 targeting ADC shows improved tolerability with long-lasting anti-tumor efficacy at low doses. Cancer Res (2023) 83 (8_Supplement): LB221.
Ref 245 A CD79b Targeting ADC with Superior Anti-Tumor Activity and Safety Resulting in Significantly Improved Therapeutic Index (TI): Safe and Efficacious CD79b ADC. Blood. 2022 ;140():11568-11569. doi: 10.1182/blood-2022-160056.
Ref 246 Development of ASG-15ME, a Novel Antibody-Drug Conjugate Targeting SLITRK6, a New Urothelial Cancer Biomarker. Mol Cancer Ther. 2016 Jun;15(6):1301-10.
Ref 247 Development of bifunctional anti-PD-L1 antibody MMAE conjugate with cytotoxicity and immunostimulation. Bioorg Chem. 2021 Nov;116:105366.
Ref 248 ADC review AVID-300
Ref 249 AVIPEP Therapeutics product pipeline
Ref 250 AXL antibody and AXL-ADC mediate antitumor efficacy via targeting AXL in tumor-intrinsic epithelial-mesenchymal transition and tumor-associated M2-like macrophage. Acta Pharmacol Sin. 2023 Jun;44(6):1290-1303.
Ref 251 AXL antibody and AXL-ADC mediate antitumor efficacy via targeting AXL in tumor-intrinsic epithelial-mesenchymal transition and tumor-associated M2-like macrophage. Acta Pharmacol Sin. 2023 Jun;44(6):1290-1303. doi: 10.1038/s41401-022-01047-6. Epub 2023 Jan 17.
Ref 252 Cooperative targeting of melanoma heterogeneity with an AXL antibody-drug conjugate and BRAF/MEK inhibitors. Nat Med. 2018 Feb;24(2):203-212.
Ref 253 Balancing Selectivity and Efficacy of Bispecific Epidermal Growth Factor Receptor (EGFR) c-MET Antibodies and Antibody-Drug Conjugates. J Biol Chem. 2016 Nov 25;291(48):25106-25119. doi: 10.1074/jbc.M116.753491. Epub 2016 Sep 30.
Ref 254 Anwita biosciences product pipeline
Ref 255 Antibody-drug conjugate; 2016-08-25.
Ref 256 NextGen conditionally active biologic (CAB) anti-Nectin-4-ADC with improved stability and safety. Cancer Res (2023) 83 (7_Supplement): 1541.
Ref 257 Cytotoxic activity of the maytansinoid immunoconjugate B-B4-DM1 against CD138+ multiple myeloma cells. Blood. 2004 Dec 1;104(12):3688-96.
Ref 258 Immunoconjugates targeting cd138 and uses thereof; 2009-07-02.
Ref 259 BCG022: A novel bispecific antibody-drug conjugate targeting HER3 and MET. Cancer Res (2023) 83 (8_Supplement): LB212.
Ref 260 Discovery of BCG033, a novel anti-PTK7 x TROP2 bispecific antibody-drug conjugate with promising efficacy against triple-negative breast cancer. Cancer Res (2023) 83 (8_Supplement): LB216.
Ref 261 Preclinical Development of a Bcma Targeting Antibody-Drug Conjugate with Novel Payload for Multiple Myeloma Therapy. Blood. 2019 ;134():-. doi: 10.1182/blood-2019-132080.
Ref 262 Discovery of novel antibody-drug conjugates bearing tissue protease specific linker with both anti-angiogenic and strong cytotoxic effects. Bioorg Chem. 2023 Aug;137:106575. doi: 10.1016/j.bioorg.2023.106575. Epub 2023 Apr 26.
Ref 263 Functional relevance of in vivo half antibody exchange of an IgG4 therapeutic antibody-drug conjugate. PLoS One. 2018 Apr 19;13(4):e0195823. doi: 10.1371/journal.pone.0195823. eCollection 2018.
Ref 264 Compact hydrophilic electrophiles enable highly efficacious high DAR ADCs with excellent in vivo PK profile. Chem Sci. 2023 Jan 3;14(9):2259-2266. doi: 10.1039/d2sc05678j. eCollection 2023 Mar 1.
Ref 265 A novel EGFR x MUC1 bispecific antibody-drug conjugate, BSA01, targets MUC1 transmembrane cleavage products and improves tumor selectivity. Cancer Res (2023) 83 (7_Supplement): 6325.
Ref 266 Introduction to basic information on ADC drug Bstrongximab ADC (CureMeta).
Ref 267 The monoclonal antibody nBT062 conjugated to cytotoxic Maytansinoids has selective cytotoxicity against CD138-positive multiple myeloma cells in vitro and in vivo. Clin Cancer Res. 2009 Jun 15;15(12):4028-37.
Ref 268 Tumor stroma-targeted antibody-drug conjugate triggers localized anticancer drug release. J Clin Invest. 2018 Jul 2;128(7):2927-2943. doi: 10.1172/JCI120481. Epub 2018 Jun 4.
Ref 269 Highly Potent, Anthracycline-based Antibody-Drug Conjugates Generated by Enzymatic, Site-specific Conjugation. Mol Cancer Ther. 2017 May;16(5):879-892.
Ref 270 Divinylpyrimidine reagents generate antibody-drug conjugates with excellent in vivo efficacy and tolerability. Chem Commun (Camb). 2022 Feb 8;58(12):1962-1965. doi: 10.1039/d1cc06766d.
Ref 271 Protease-activated drug development. Theranostics. 2012;2(2):156-78.
Ref 272 Coare biopharmaceutical company product pipeline
Ref 273 Cybrexa therapeutics product pipeline
Ref 274 A coiled-coil masking domain for selective activation of therapeutic antibodies. Nat Biotechnol. 2019 Jul;37(7):761-765. doi: 10.1038/s41587-019-0135-x. Epub 2019 May 27.
Ref 275 Preclinical Development of an Anti-CD38 Antibody-Drug Conjugate for Treatment of Hematological Malignancies. Blood. 2019 ;134():-. doi: 10.1182/blood-2019-132062.
Ref 276 Conditionally active biologics (CAB): A novel class of molecules targeting solid tumors. Cancer Res (2020) 80 (16_Supplement): 4560.
Ref 277 Antibody-drug conjugate targeting CD46 eliminates multiple myeloma cells. J Clin Invest. 2016 Dec 1;126(12):4640-4653. doi: 10.1172/JCI85856. Epub 2016 Nov 14.
Ref 278 Chemical Artificial Internalizing Receptors for Primary T Cells. Adv Sci (Weinh). 2020 Jul 26;7(18):2001395. doi: 10.1002/advs.202001395. eCollection 2020 Sep.
Ref 279 CD70 antibody-drug conjugate as a potential therapeutic agent for uterine leiomyosarcoma. Am J Obstet Gynecol. 2021 Feb;224(2):197.e1-197.e23. doi: 10.1016/j.ajog.2020.08.028. Epub 2020 Aug 19.
Ref 280 Discovery and Optimization of HKT288, a Cadherin-6-Targeting ADC for the Treatment of Ovarian and Renal Cancers. Cancer Discov. 2017 Sep;7(9):1030-1045.
Ref 281 Monomethyl auristatin antibody and peptide drug conjugates for trimodal cancer chemo-radio-immunotherapy. Nat Commun. 2022 Jul 5;13(1):3869. doi: 10.1038/s41467-022-31601-z.
Ref 282 An anti-EGFR antibody-drug conjugate overcomes resistance to HER2-targeted drugs. Cancer Lett. 2023 Feb 1;554:216024.
Ref 283 EGFR binding Fc domain-drug conjugates: stable and highly potent cytotoxic molecules mediate selective cell killing. Biol Chem. 2021 Sep 20;403(5-6):525-534.
Ref 284 Therapeutic efficacy of antibody-drug conjugates targeting GD2-positive tumors. J Immunother Cancer. 2022 Jun;10(6):e004646. doi: 10.1136/jitc-2022-004646.
Ref 285 Antibody-Mediated Endocytosis of Polysialic Acid Enables Intracellular Delivery and Cytotoxicity of a Glycan-Directed Antibody-Drug Conjugate. Cancer Res. 2019 Apr 15;79(8):1810-1821. doi: 10.1158/0008-5472.CAN-18-3119. Epub 2019 Feb 26.
Ref 286 Novel b7-h3 binding molecules, antibody drug conjugates thereof and methods of use thereof; 2017-10-19.
Ref 287 Cirmtuzumab Vedotin (UC-961ADC3), An Anti-ROR1-Monomethyl Auristatin E Antibody-Drug Conjugate, Is a Potential Treatment For ROR1-Positive Leukemia and Solid Tumors. Blood (2013) 122 (21): 1637.
Ref 288 Development of Cirmtuzumab Antibody-Drug Conjugates (ADCs) Targeting Receptor Tyrosine Kinase-like Orphan Receptor 1 (ROR1). Blood. 2018 ;132():-. doi: 10.1182/blood-2018-99-119447.
Ref 289 Improving the response to oxaliplatin by targeting chemotherapy-induced CLDN1 in resistant metastatic colorectal cancer cells. Cell Biosci. 2023 Apr 11;13(1):72. doi: 10.1186/s13578-023-01015-5.
Ref 290 Incorporation of Hydrophilic Macrocycles Into Drug-Linker Reagents Produces Antibody-Drug Conjugates With Enhanced in vivo Performance. Front Pharmacol. 2022 Jun 17;13:764540. doi: 10.3389/fphar.2022.764540. eCollection 2022.
Ref 291 Antibody drug conjugate using CTAT linker technology shows superior efficacy in xenograft trial; 2015
Ref 292 Controlled coupling of an ultrapotent auristatin warhead to cetuximab yields a next-generation antibody-drug conjugate for EGFR-targeted therapy of KRAS mutant pancreatic cancer. Br J Cancer. 2020 Nov;123(10):1502-1512. doi: 10.1038/s41416-020-01046-6. Epub 2020 Sep 11.
Ref 293 Antibody-Drug Conjugate Using Ionized Cys-Linker-MMAE as the Potent Payload Shows Optimal Therapeutic Safety. Cancers (Basel). 2020 Mar 21;12(3):744. doi: 10.3390/cancers12030744.
Ref 294 APOMAB Antibody-Drug Conjugates Targeting Dead Tumor Cells are Effective In Vivo. Mol Cancer Ther. 2019 Feb;18(2):335-345. doi: 10.1158/1535-7163.MCT-18-0842. Epub 2018 Nov 9.
Ref 295 Dantari biotechnology company product pipeline
Ref 296 Site-specific antibody-drug conjugates with variable drug-to-antibody-ratios for AML therapy. J Control Release. 2021 Aug 10;336:433-442. doi: 10.1016/j.jconrel.2021.06.041. Epub 2021 Jun 29.
Ref 297 Development of Novel Quaternary Ammonium Linkers for Antibody-Drug Conjugates. Mol Cancer Ther. 2016 May;15(5):938-45. doi: 10.1158/1535-7163.MCT-16-0038. Epub 2016 Mar 4.
Ref 298 A Toxin-Conjugated Recombinant Protein Targeting gp120 and gp41 for Inactivating HIV-1 Virions and Killing Latency-Reversing Agent-Reactivated Latent Cells. mBio. 2022 Feb 22;13(1):e0338421. doi: 10.1128/mbio.03384-21. Epub 2022 Jan 18.
Ref 299 Introduction to basic information on ADC drug DM003.
Ref 300 Identification of DM004, a first-in-class anti-5T4/MET bispecific antibody-drug conjugate. Cancer Res (2023) 83 (8_Supplement): LB213.
Ref 301 Tumor uptake and associated greater efficacy of anti-Her2 immunoliposome does not rely on Her2 expression status: study of a docetaxel-trastuzumab immunoliposome on Her2+ breast cancer model (SKBR3). Anticancer Drugs. 2020 Jun;31(5):463-472. doi: 10.1097/CAD.0000000000000878.
Ref 302 A ca6 antigen-specific cytotoxic conjugate and methods of using the same; 2005-02-03
Ref 303 Anti-Extra Domain B Splice Variant of Fibronectin Antibody-Drug Conjugate Eliminates Tumors with Enhanced Efficacy When Combined with Checkpoint Blockade. Mol Cancer Ther. 2022 Sep 6;21(9):1462-1472.
Ref 304 Divinylsulfonamides enable the construction of homogeneous antibody-drug conjugates. Bioorg Med Chem. 2020 Dec 1;28(23):115793. doi: 10.1016/j.bmc.2020.115793. Epub 2020 Oct 6.
Ref 305 Hydrophilic Auristatin Glycoside Payload Enables Improved Antibody-Drug Conjugate Efficacy and Biocompatibility. Antibodies (Basel). 2018 Mar 22;7(2):15. doi: 10.3390/antib7020015.
Ref 306 Antibody drug conjugates of cleavable amino-alkyl and aryl maytansinoids. Bioorg Med Chem. 2018 May 15;26(9):2271-2279. doi: 10.1016/j.bmc.2018.02.025. Epub 2018 Feb 21.
Ref 307 Compounds, linker-drugs and ligand-drug conjugates; 2020-06-16
Ref 308 Introduction to basic information on eribulin ADC (Jiangsu hengrui)
Ref 309 EV20-mediated delivery of cytotoxic auristatin MMAF exhibits potent therapeutic efficacy in cutaneous melanoma. J Control Release. 2018 May 10;277:48-56. doi: 10.1016/j.jconrel.2018.03.016. Epub 2018 Mar 14.
Ref 310 Glutamic acid-valine-citrulline linkers ensure stability and efficacy of antibody-drug conjugates in mice. Nat Commun. 2018 Jun 28;9(1):2512. doi: 10.1038/s41467-018-04982-3.
Ref 311 A FZD7-specific Antibody-Drug Conjugate Induces Ovarian Tumor Regression in Preclinical Models. Mol Cancer Ther. 2022 Jan;21(1):113-124.
Ref 312 Folate receptor 1 antibodies and immunoconjugates and uses thereof; 2011-09-01.
Ref 313 MORAb-202, an Antibody-Drug Conjugate Utilizing Humanized Anti-human FR Farletuzumab and the Microtubule-targeting Agent Eribulin, has Potent Antitumor Activity. Mol Cancer Ther. 2018 Dec;17(12):2665-2675. doi: 10.1158/1535-7163.MCT-17-1215. Epub 2018 Sep 27.
Ref 314 Therapeutic Potential of MF-TTZ-MMAE, a Site-Specifically Conjugated Antibody-Drug Conjugate, for the Treatment of HER2-Overexpressing Breast Cancer. Bioconjug Chem. 2022 Feb 16;33(2):418-426. doi: 10.1021/acs.bioconjchem.2c00015. Epub 2022 Feb 1.
Ref 315 A novel ADC targeting cell surface fibromodulin in a mouse model of triple-negative breast cancer. Breast Cancer. 2022 Nov;29(6):1121-1132. doi: 10.1007/s12282-022-01393-7. Epub 2022 Aug 18.
Ref 316 Identification and Validation of a Novel Biologics Target in Triple Negative Breast Cancer. Sci Rep. 2019 Oct 17;9(1):14934. doi: 10.1038/s41598-019-51453-w.
Ref 317 Introduction to basic information on ADC drug GB-7008-01-vcMMAE.
Ref 318 The antibody-drug conjugate GENA-111 conjugated to auristatin F shows therapeutic potency in BCAM positive epithelial cancer. 2022.
Ref 319 Anti-tumor efficacy of GMF-1A3, an MMAE-based antibody drug conjugate targeting cell surface cleaved Amphiregulin in breast cancer. Cancer Res (2023) 83 (7_Supplement): 562.
Ref 320 Anti-glypican-1 antibody-drug conjugate exhibits potent preclinical antitumor activity against glypican-1 positive uterine cervical cancer. Int J Cancer. 2018 Mar 1;142(5):1056-1066. doi: 10.1002/ijc.31124. Epub 2017 Oct 31.
Ref 321 Anti-glypican-1 antibody-drug conjugate is a potential therapy against pancreatic cancer. Br J Cancer. 2020 Apr;122(9):1333-1341. doi: 10.1038/s41416-020-0781-2. Epub 2020 Mar 10.
Ref 322 A glypican-1-targeted antibody-drug conjugate exhibits potent tumorgrowth inhibition in glypican-1-positive pancreatic cancer and esophageal squamous cell carcinoma. Neoplasia. 2021 Sep;23(9):939-950.
Ref 323 Anti-Glypican-1 Antibody-drug Conjugate as Potential Therapy Against Tumor Cells and Tumor Vasculature for Glypican-1-Positive Cholangiocarcinoma. Mol Cancer Ther. 2021 Sep;20(9):1713-1722. doi: 10.1158/1535-7163.MCT-21-0015. Epub 2021 Jun 17.
Ref 324 Anti-cdh6 antibody and anti-cdh6 antibody-drug conjugate.
Ref 325 Hydrophilic antibody-drug conjugates; 2015-08-20.
Ref 326 Tridentate connexon and use thereof.
Ref 327 Preparation and characterization of antibody-drug conjugates acting on HER2-positive cancer cells. PLoS One. 2020 Sep 28;15(9):e0239813. doi: 10.1371/journal.pone.0239813. eCollection 2020.
Ref 328 Two engineered site-specific antibody-drug conjugates, HLmD4 and HLvM4, have potent therapeutic activity in two DLL4-positive tumour xenograft models. Am J Cancer Res. 2020 Aug 1;10(8):2387-2408. eCollection 2020.
Ref 329 Development of ASG-15ME, a Novel Antibody-Drug Conjugate Targeting SLITRK6, a New Urothelial Cancer Biomarker. Mol Cancer Ther. 2016 Jun;15(6):1301-10. doi: 10.1158/1535-7163.MCT-15-0570. Epub 2016 Mar 4.
Ref 330 The HB22.7 Anti-CD22 Monoclonal Antibody Is an Effective Platform for CD22-Targeted Antibody Drug Conjugates for Treatment of Lymphoma and Acute Lymphoblastic Leukemia. Blood. 2012 ;120(21):-. doi: 10.1182/blood.V120.21.1653.1653.
Ref 331 A novel antibody-drug conjugate, HcHAb18-DM1, has potent anti-tumor activity against human non-small cell lung cancer. Biochem Biophys Res Commun. 2019 Jun 11;513(4):1083-1091. doi: 10.1016/j.bbrc.2019.04.046. Epub 2019 Apr 19.
Ref 332 A Novel Family of Acid-Cleavable Linker Based on Cyclic Acetal Motifs for the Production of Antibody-Drug Conjugates with High Potency and Selectivity. Bioconjug Chem. 2022 Oct 19;33(10):1860-1866. doi: 10.1021/acs.bioconjchem.2c00314. Epub 2022 Sep 15.
Ref 333 One-Pot Conversion of Free Sialoglycans to Functionalized Glycan Oxazolines and Efficient Synthesis of Homogeneous Antibody-Drug Conjugates through Site-Specific Chemoenzymatic Glycan Remodeling. Bioconjug Chem. 2021 Aug 18;32(8):1888-1897. doi: 10.1021/acs.bioconjchem.1c00314. Epub 2021 Aug 5.
Ref 334 Hiding Payload Inside the IgG Fc Cavity Significantly Enhances the Therapeutic Index of Antibody-Drug Conjugates. J Med Chem. 2023 Jan 12;66(1):1011-1026. doi: 10.1021/acs.jmedchem.2c01812. Epub 2022 Dec 30.
Ref 335 Antibody-Drug Conjugates Used in Breast Cancers. J Oncol. 2021 Jun 24;2021:9927433. doi: 10.1155/2021/9927433. eCollection 2021.
Ref 336 Humanization of JAA-F11, a Highly Specific Anti-Thomsen-Friedenreich Pancarcinoma Antibody and InVitro Efficacy Analysis. Neoplasia. 2017 Sep;19(9):716-733. doi: 10.1016/j.neo.2017.07.001. Epub 2017 Aug 19.
Ref 337 Anti-cd228 antibodies and antibody-drug conjugates; 2022-02-10.
Ref 338 Anti-huLRRC15 antibody drug conjugates and methods for their use. 2017-06-08
Ref 339 IMGN853, a Folate Receptor- (FR)-Targeting Antibody-Drug Conjugate, Exhibits Potent Targeted Antitumor Activity against FR-Expressing Tumors. Mol Cancer Ther. 2015 Jul;14(7):1605-13.
Ref 340 Introduction to basic information on humanized anti-HER2 mab-maytansine conjugate(Anhui Anke Biotechnology/Wuxi Pharmatech).
Ref 341 An overview of huPr1-vcMMAE.
Ref 342 Evaluation of endoglin/CD105 as a tumor vasculature target with antibody drug conjugates. Cancer Res (2018) 78 (13_Supplement): 2900.
Ref 343 Therapeutic effect of a MUC1-specific monoclonal antibody-drug conjugates against pancreatic cancer model. Cancer Cell Int. 2022 Dec 27;22(1):417.
Ref 344 A rationally designed ICAM1 antibody drug conjugate eradicates late-stage and refractory triple-negative breast tumors in vivo. Sci Adv. 2023 May 5;9(18):eabq7866. doi: 10.1126/sciadv.abq7866. Epub 2023 May 5.
Ref 345 A Rationally Designed ICAM1 Antibody Drug Conjugate for Pancreatic Cancer. Adv Sci (Weinh). 2020 Nov 3;7(24):2002852. doi: 10.1002/advs.202002852.
Ref 346 Antibody-drug conjugates with HER2-targeting antibodies from synthetic antibody libraries are highly potent against HER2-positive human gastric tumor in xenograft models. MAbs. 2019 Jan;11(1):153-165. doi: 10.1080/19420862.2018.1541370. Epub 2018 Nov 8.
Ref 347 Antibody-drug conjugates targeting CD248(+) myofibroblasts effectively alleviate renal fibrosis in mice. FASEB J. 2022 Feb;36(2):e22102. doi: 10.1096/fj.202101441R.
Ref 348 Introduction to basic information on ADC drug IGN-786
Ref 349 EphA3 Pay-Loaded Antibody Therapeutics for the Treatment of Glioblastoma. Cancers (Basel). 2018 Dec 17;10(12):519. doi: 10.3390/cancers10120519.
Ref 350 Preclinical characterization of the safety and antitumor activity of IMAB027-vcMMAE, an anticlaudin 6 antibody-drug conjugate. Cancer Res (2018) 78 (13_Supplement): 1778.
Ref 351 Anti-claudin 18.2 antibody and antibody-drug conjugate thereof; 2022-11-17.
Ref 352 Introduction to basic information on ADC drug IMAB362-VCMMAE.
Ref 353 Introduction to basic information on ADC drug IMB-101 and IMB-102.
Ref 354 Development of a new minimally invasive phototherapy for lung cancer using antibody-toxin conjugate. Thorac Cancer. 2023 Mar;14(7):645-653. doi: 10.1111/1759-7714.14776. Epub 2023 Jan 19.
Ref 355 A novel pegylated bispecific antibody-drug conjugate (P-BsADCpb-adc) targeting cancers co-expressing PD-L1 and CD47. Cancer Res (2023) 83 (7_Supplement): 6307.
Ref 356 LCB97, an antibody drug conjugate (ADC) targeting a novel tumor antigen for the treatment of multiple solid tumors. Cancer Res (2023) 83 (7_Supplement): 5653.
Ref 357 An Elaborate New Linker System Significantly Enhances the Efficacy of an HER2-Antibody-Drug Conjugate against Refractory HER2-Positive Cancers. Adv Sci (Weinh). 2021 Dec;8(23):e2102414. doi: 10.1002/advs.202102414. Epub 2021 Oct 18.
Ref 358 Excellent effects and possible mechanisms of action of a new antibody-drug conjugate against EGFR-positive triple-negative breast cancer. Mil Med Res. 2021 Dec 9;8(1):63.
Ref 359 Rational Design and Systemic Appraisal of an EGFR-Targeting Antibody-Drug Conjugate LR-DM1 for Pancreatic Cancer. J Med Chem. 2022 May 26;65(10):7141-7153. doi: 10.1021/acs.jmedchem.1c01920. Epub 2022 May 6.
Ref 360 Leucine-rich alpha-2-glycoprotein 1 (LRG1) as a novel ADC target. RSC Chem Biol. 2021 May 31;2(4):1206-1220.
Ref 361 Lipolysis-stimulated lipoprotein receptor-targeted antibody-drug conjugate demonstrates potent antitumor activity against epithelial ovarian cancer. Neoplasia. 2023 Jan;35:100853.
Ref 362 A novel molecule with profound tumor killing activity. Cancer Res (2019) 79 (13_Supplement): 353.
Ref 363 ALPPL2 Is a Highly Specific and Targetable Tumor Cell Surface Antigen. Cancer Res. 2020 Oct 15;80(20):4552-4564. doi: 10.1158/0008-5472.CAN-20-1418. Epub 2020 Aug 31.
Ref 364 A Novel Antibody-Toxin Conjugate to Treat Mantle Cell Lymphoma. Front Oncol. 2019 Apr 10;9:258. doi: 10.3389/fonc.2019.00258. eCollection 2019.
Ref 365 A Case Study Comparing Heterogeneous Lysine- and Site-Specific Cysteine-Conjugated Maytansinoid Antibody-Drug Conjugates (ADCs) Illustrates the Benefits of Lysine Conjugation. Mol Pharm. 2019 Sep 3;16(9):3926-3937. doi: 10.1021/acs.molpharmaceut.9b00529. Epub 2019 Jul 31.
Ref 366 An anti-mesothelin targeting antibody drug conjugate induces pyroptosis and ignites antitumor immunity in mouse models of cancer. J Immunother Cancer. 2023 Mar;11(3):e006274. doi: 10.1136/jitc-2022-006274.
Ref 367 Innovative Bioconjugation Technology for Antibody-Drug Conjugates: Proof of Concept in a CD30-Positive Lymphoma Mouse Model. Bioconjug Chem. 2021 Mar 17;32(3):595-606. doi: 10.1021/acs.bioconjchem.1c00058. Epub 2021 Feb 25.
Ref 368 MI130004, a Novel Antibody-Drug Conjugate Combining Trastuzumab with a Molecule of Marine Origin, Shows Outstanding In Vivo Activity against HER2-Expressing Tumors. Mol Cancer Ther. 2018 Apr;17(4):786-794. doi: 10.1158/1535-7163.MCT-17-0795. Epub 2018 Feb 13.
Ref 369 CD13 as a new tumor target for antibody-drug conjugates: validation with the conjugate MI130110. J Hematol Oncol. 2020 Apr 7;13(1):32. doi: 10.1186/s13045-020-00865-7.
Ref 370 Introduction to basic information on ADC drug anti-FR (clone M9346A)-SPDB-DM4.
Ref 371 Old Drug, New Delivery Strategy: MMAE Repackaged. Int J Mol Sci. 2023 May 10;24(10):8543. doi: 10.3390/ijms24108543.
Ref 372 An auristatin-based antibody-drug conjugate targeting HER3 enhances the radiation response in pancreatic cancer. Int J Cancer. 2019 Oct 1;145(7):1838-1851. doi: 10.1002/ijc.32273. Epub 2019 Apr 1.
Ref 373 Human antibodies targeting ENPP1 as candidate therapeutics for cancers. Front Immunol. 2023 Jan 25;14:1070492. doi: 10.3389/fimmu.2023.1070492. eCollection 2023.
Ref 374 Effectiveness of HB2 (anti-CD7)--saporin immunotoxin in an in vivo model of human T-cell leukaemia developed in severe combined immunodeficient mice. Br J Cancer. 1994 Feb;69(2):279-85. doi: 10.1038/bjc.1994.52.
Ref 375 Mediapharma product pipeline
Ref 376 Mediapharma product pipeline
Ref 377 MP-EV20-ADC: humanized anti-HER3 antibody drug conjugate
Ref 378 Anti-MSLN ADC against cancer; institute of pharmaceutics development center for biotechnology; 2020
Ref 379 A clinical candidate anti-mesothelin-MMAE antibody-drug conjugate (ADC) for therapy of mesothelin-expressing cancers. Cancer Res (2014) 74 (19_Supplement): 4494.
Ref 380 Nectin-4: a new prognostic biomarker for efficient therapeutic targeting of primary and metastatic triple-negative breast cancer. Ann Oncol. 2017 Apr 1;28(4):769-776. doi: 10.1093/annonc/mdw678.
Ref 381 Preclinical evaluation of NC-6201, an antibody/drug-conjugated micelle incorporating novel hemiasterlin analogue E7974.
Ref 382 Design and Validation of Linkers for Site-Specific Preparation of Antibody-Drug Conjugates Carrying Multiple Drug Copies Per Cysteine Conjugation Site. Int J Mol Sci. 2020 Sep 19;21(18):6882. doi: 10.3390/ijms21186882.
Ref 383 A novel anti-c-Kit antibody-drug conjugate to treat wild-type and activating-mutant c-Kit-positive tumors. Mol Oncol. 2022 Mar;16(6):1290-1308.
Ref 384 Preclinical evaluation of a novel antibody-drug conjugate targeting DR5 for lymphoblastic leukemia therapy. Mol Ther Oncolytics. 2021 Apr 29;21:329-339. doi: 10.1016/j.omto.2021.04.013. eCollection 2021 Jun 25.
Ref 385 Introduction to basic information on ADC drug Oberotatug ravtansine.
Ref 386 Preclinical characterization of a novel SSEA-4-targeting antibody drug conjugate, OBI-998. Cancer Res (2021) 81 (13_Supplement): 955.
Ref 387 Antibody-Drug Conjugates Using Mouse-Canine Chimeric Anti-Dog Podoplanin Antibody Exerts Antitumor Activity in a Mouse Xenograft Model. Monoclon Antib Immunodiagn Immunother. 2020 Apr;39(2):37-44. doi: 10.1089/mab.2020.0001. Epub 2020 Mar 17.
Ref 388 Old target, but new approach: Targeting cancer-associated MUC1 with ADC and Car-T. Cancer Res (2020) 80 (16_Supplement): 6530.
Ref 389 Therapeutic efficacy of a novel humanized antibody-drug conjugate recognizing plexin-semaphorin-integrin domain in the RON receptor for targeted cancer therapy. J Immunother Cancer. 2019 Sep 13;7(1):250. doi: 10.1186/s40425-019-0732-8.
Ref 390 MET and RON receptor tyrosine kinases in colorectal adenocarcinoma: molecular features as drug targets and antibody-drug conjugates for therapy. J Exp Clin Cancer Res. 2020 Sep 22;39(1):198. doi: 10.1186/s13046-020-01711-x.
Ref 391 Drug Conjugation via Maleimide-Thiol Chemistry Does Not Affect Targeting Properties of Cysteine-Containing Anti-FGFR1 Peptibodies. Mol Pharm. 2022 May 2;19(5):1422-1433.
Ref 392 Targeting a Tumor-Specific Epitope on Podocalyxin Increases Survival in Human Tumor Preclinical Models. Front Oncol. 2022 May 4;12:856424.
Ref 393 Preparation and anti-cancer evaluation of promiximab-MMAE, an anti-CD56 antibody drug conjugate, in small cell lung cancer cell line xenograft models. J Drug Target. 2018 Dec;26(10):905-912. doi: 10.1080/1061186X.2018.1450413. Epub 2018 Apr 13.
Ref 394 Post translational modification therapeutics product pipeline
Ref 395 Antibody molecules and conjugates; 2023-05-19.
Ref 396 Antibody drug conjugates against the receptor for advanced glycation end products (RAGE), a novel therapeutic target in endometrial cancer. J Immunother Cancer. 2019 Oct 29;7(1):280. doi: 10.1186/s40425-019-0765-z.
Ref 397 Monomethyl auristatin E-conjugated anti-EGFR antibody inhibits the growth of human EGFR-positive non-small cell lung cancer. Cancer Chemother Pharmacol. 2019 Jul;84(1):61-72. doi: 10.1007/s00280-019-03848-9. Epub 2019 Apr 29.
Ref 398 Anti-mesothelin antibody and antibody-drug conjugate thereof; 2019-11-28.
Ref 399 Preclinical Activity of the Novel Anti-Prolactin Receptor (PRLR) Antibody-Drug Conjugate REGN2878-DM1 in PRLR-Positive Breast Cancers. Mol Cancer Ther. 2017 Jul;16(7):1299-1311. doi: 10.1158/1535-7163.MCT-16-0839. Epub 2017 Apr 4.
Ref 400 RN765C, a low affinity EGFR antibody drug conjugate with potent anti-tumor activity in preclinical solid tumor models. Oncotarget. 2018 Sep 11;9(71):33446-33458. doi: 10.18632/oncotarget.26002. eCollection 2018 Sep 11.
Ref 401 RN927C, a Site-Specific Trop-2 Antibody-Drug Conjugate (ADC) with Enhanced Stability, Is Highly Efficacious in Preclinical Solid Tumor Models. Mol Cancer Ther. 2016 Nov;15(11):2698-2708. doi: 10.1158/1535-7163.MCT-16-0431. Epub 2016 Aug 31.
Ref 402 Treatment of ovarian cancer by targeting the tumor stem cell-associated carbohydrate antigen, Sialyl-Thomsen-nouveau. Oncotarget. 2018 May 1;9(33):23289-23305. doi: 10.18632/oncotarget.25289. eCollection 2018 May 1.
Ref 403 A multivalent biparatopic EGFR-targeting nanobody drug conjugate displays potent anticancer activity in solid tumor models. Signal Transduct Target Ther. 2021 Sep 3;6(1):320. doi: 10.1038/s41392-021-00666-5.
Ref 404 Novel antibody conjugates and uses thereof; 2014-08-28.
Ref 405 Generation of high-affinity, internalizing anti-FGFR2 single-chain variable antibody fragment fused with Fc for targeting gastrointestinal cancers. PLoS One. 2018 Feb 8;13(2):e0192194. doi: 10.1371/journal.pone.0192194. eCollection 2018.
Ref 406 Activated platelets in the tumor microenvironment for targeting of antibody-drug conjugates to tumors and metastases. Theranostics. 2019 Feb 7;9(4):1154-1169. doi: 10.7150/thno.29146. eCollection 2019.
Ref 407 Antibody targeting of B-cell maturation antigen on malignant plasma cells. Mol Cancer Ther. 2007 Nov;6(11):3009-18. doi: 10.1158/1535-7163.MCT-07-0464.
Ref 408 Discovery of A Novel EGFR-Targeting Antibody-Drug Conjugate, SHR-A1307, for the Treatment of Solid Tumors Resistant or Refractory to Anti-EGFR Therapies. Mol Cancer Ther. 2019 Jun;18(6):1104-1114. doi: 10.1158/1535-7163.MCT-18-0854.
Ref 409 Anti-tumor activity of antibody drug conjugate targeting aspartate--hydroxylase in pancreatic ductal adenocarcinoma. Cancer Lett. 2019 May 1;449:87-98. doi: 10.1016/j.canlet.2019.02.006. Epub 2019 Feb 12.
Ref 410 Introduction to basic information on ADC drug ST1.
Ref 411 N-terminal selective conjugation method widens the therapeutic window of antibody-drug conjugates by improving tolerability and stability. MAbs. 2021 Jan-Dec;13(1):1914885. doi: 10.1080/19420862.2021.1914885.
Ref 412 Cyclopentadiene as a Multifunctional Reagent for Normal- and Inverse-Electron Demand Diels-Alder Bioconjugation. Bioconjug Chem. 2022 Sep 21;33(9):1609-1619.
Ref 413 Near-infrared-induced drug release from antibody-drug double conjugates exerts a cytotoxic photo-bystander effect. Bioeng Transl Med. 2022 Aug 21;7(3):e10388. doi: 10.1002/btm2.10388. eCollection 2022 Sep.
Ref 414 Photoconjugation of an Fc-Specific Peptide Enables Efficient DAR 2 Antibody-Drug Conjugate Formation. Org Lett. 2020 Nov 6;22(21):8419-8423. doi: 10.1021/acs.orglett.0c03049. Epub 2020 Oct 19.
Ref 415 The cytotoxic conjugate of highly internalizing tetravalent antibody for targeting FGFR1-overproducing cancer cells. Mol Med. 2021 May 7;27(1):46. doi: 10.1186/s10020-021-00306-2.
Ref 416 Tissue factor-targeted antibody-drug conjugate; 2018-03-01.
Ref 417 Targeting HER2-positive breast cancer with trastuzumab-DM1, an antibody-cytotoxic drug conjugate. Cancer Res. 2008 Nov 15;68(22):9280-90.
Ref 418 Development of applicable thiol-linked antibody-drug conjugates with improved stability and therapeutic index. Drug Deliv. 2022 Dec;29(1):754-766. doi: 10.1080/10717544.2022.2039807.
Ref 419 Tag-free, specific conjugation of glycosylated IgG1 antibodies using microbial transglutaminase. RSC Adv. 2022 Nov 22;12(52):33510-33515. doi: 10.1039/d2ra05630e. eCollection 2022 Nov 22.
Ref 420 Antibody-nanoparticle conjugate constructed with trastuzumab and nanoparticle albumin-bound paclitaxel for targeted therapy of human epidermal growth factor receptor?2-positive gastric cancer. Oncol Rep. 2018 Mar;39(3):1396-1404. doi: 10.3892/or.2018.6201. Epub 2018 Jan 9.
Ref 421 Biological Evaluation of Maytansinoid-Based Site-Specific Antibody-Drug Conjugate Produced by Fully Chemical Conjugation Approach: AJICAP. Front Biosci (Landmark Ed). 2022 Aug 5;27(8):234.
Ref 422 Enzymatic glycan remodeling-metal free click (GlycoConnect) provides homogenous antibody-drug conjugates with improved stability and therapeutic index without sequence engineering. MAbs. 2022 Jan-Dec;14(1):2078466.
Ref 423 Trastuzumab-deBouganin Conjugate Overcomes Multiple Mechanisms of T-DM1 Drug Resistance. J Immunother. 2016 Apr;39(3):117-26. doi: 10.1097/CJI.0000000000000115.
Ref 424 Peroxide-cleavable linkers for antibody-drug conjugates. Chem Commun (Camb). 2023 Feb 9;59(13):1841-1844. doi: 10.1039/d2cc06677g.
Ref 425 Synthesis and Evaluation of Three Azide-Modified Disaccharide Oxazolines as Enzyme Substrates for Single-Step Fc Glycan-Mediated Antibody-Drug Conjugation. Bioconjug Chem. 2022 Jun 15;33(6):1179-1191.
Ref 426 Antibody-Drug Conjugate that Exhibits Synergistic Cytotoxicity with an Endosome-Disruptive Peptide. ACS Omega. 2019 Jul 31;4(7):12955-12968. doi: 10.1021/acsomega.9b01585. eCollection 2019 Jul 31.
Ref 427 General and Robust Chemoenzymatic Method for Glycan-Mediated Site-Specific Labeling and Conjugation of Antibodies: Facile Synthesis of Homogeneous Antibody-Drug Conjugates. ACS Chem Biol. 2021 Nov 19;16(11):2502-2514.
Ref 428 Impact of cathepsin B-sensitive triggers and hydrophilic linkers on in vitro efficacy of novel site-specific antibody-drug conjugates. Org Biomol Chem. 2018 Mar 14;16(11):1882-1889. doi: 10.1039/c7ob02780j.
Ref 429 Develop highly specific cell engager constructs with improved function and safety by understanding target-effector cell avidity.
Ref 430 Beta-glucuronide-linker drug conjugates; 2007-10-25.
Ref 431 Methylene carbamate linkers for use with targeted-drug conjugates; 2015-06-25.
Ref 432 Site-specific conjugation of linker drugs to antibodies and resulting adcs.
Ref 433 Conjugates comprising self-immolative groups and methods related thereto.
Ref 434 Antibody-drug conjugates comprising branched linkers and methods related thereto; 2017-06-01.
Ref 435 Antibody-drug conjugate comprising antibody against human ror1, and use for the same; 2021-04-01.
Ref 436 A first-in-class anti-HER2/TROP2 bispecific antibody-drug conjugate (YH012) exhibits potent anti-tumor efficacy. Cancer Res (2023) 83 (7_Supplement): 2977.
Ref 437 YH013, a novel EGFR x MET bispecific antibody-drug conjugate, exhibits potent antitumor efficacy. Cancer Res (2023) 83 (7_Supplement): 2978.
Ref 438 A novel anti-DR5 antibody-drug conjugate possesses a high-potential therapeutic efficacy for leukemia and solid tumors. Theranostics. 2019 Jul 13;9(18):5412-5423. doi: 10.7150/thno.33598. eCollection 2019.
Ref 439 Comparison of HER2-targeted affibody conjugates loaded with auristatin- and maytansine-derived drugs. J Control Release. 2023 Mar;355:515-527. doi: 10.1016/j.jconrel.2023.02.005. Epub 2023 Feb 14.
Ref 440 Efficacy of anti-RON antibody Zt/g4-drug maytansinoid conjugation (Anti-RON ADC) as a novel therapeutics for targeted colorectal cancer therapy. Clin Cancer Res. 2014 Dec 1;20(23):6045-58. doi: 10.1158/1078-0432.CCR-14-0898. Epub 2014 Oct 7.
Ref 441 Preclinical Efficacy of Anti-RON Antibody-Drug Conjugate Zt/g4-MMAE for Targeted Therapy of Pancreatic Cancer Overexpressing RON Receptor Tyrosine Kinase. Mol Pharm. 2018 Aug 6;15(8):3260-3271. doi: 10.1021/acs.molpharmaceut.8b00298. Epub 2018 Jun 26.
Ref 442 Antitumor activity of a 5T4 targeting antibody drug conjugate with a novel payload derived from MMAF via C-Lock linker. Cancer Med. 2019 Apr;8(4):1793-1805. doi: 10.1002/cam4.2066. Epub 2019 Mar 7.
Ref 443 Recombinant anti-cd30 antibodies and uses thereof; 2006-02-02
Ref 444 Introduction to basic information on ADC drug Alpha-CD70-Mc-MMAF
Ref 445 Biodistribution and efficacy of an anti-TENB2 antibody-drug conjugate in a patient-derived model of prostate cancer. Oncotarget. 2019 Oct 22;10(58):6234-6244. doi: 10.18632/oncotarget.27263. eCollection 2019 Oct 22.
Ref 446 Tasly pharma announcement; 2020
Ref 447 Site-Specific Conjugation of Monomethyl Auristatin E to Anti-CD30 Antibodies Improves Their Pharmacokinetics and Therapeutic Index in Rodent Models. Mol Pharm. 2015 Jun 1;12(6):1863-71. doi: 10.1021/mp500666j. Epub 2015 Feb 9.
Ref 448 Introduction to basic information on ADC drug ADC-W-2589.
Ref 449 Introduction to basic information on ADC drug C-met monoclonal antibody-drug conjugate
Ref 450 Introduction to basic information on EGFRvIII/MMAE antibody drug conjugate(Abgenix, Inc.).
Ref 451 In vitro and in vivo activity of a highly potent and novel FGFR2/FGFR4 dual targeting antibody-drug conjugate. Cancer Res (2015) 75 (15_Supplement): 1680.
Ref 452 Development and Evaluation of a Fluorescent Antibody-Drug Conjugate for Molecular Imaging and Targeted Therapy of Pancreatic Cancer. PLoS One. 2016 Jun 23;11(6):e0157762. doi: 10.1371/journal.pone.0157762. eCollection 2016.
Ref 453 Antibody-drug conjugates and related compounds, compositions, and methods.