Antibody-drug Conjugate Information
General Information of This Antibody-drug Conjugate (ADC)
| ADC ID |
DRG0VOTVV
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|---|---|---|---|---|---|---|
| ADC Name |
Sal5-DM4
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| Synonyms |
Sal5 DM4
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| Drug Status |
Investigative
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| Indication |
In total 1 Indication(s)
Lung cancer [ICD11:2C25]
Investigative
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| Drug-to-Antibody Ratio |
4.2
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| Antibody Name |
Sal5
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Antibody Info | ||||
| Antigen Name |
Epidermal growth factor receptor (EGFR); Receptor tyrosine-protein kinase erbB-3 (ERBB3)
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Antigen Info | ||||
| Payload Name |
Mertansine DM4
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Payload Info | ||||
| Therapeutic Target |
Microtubule (MT)
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Target Info | ||||
| Linker Name |
N-succinimidyl 4-(2-pyridyldithio) butanoate (SPDB)
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Linker Info | ||||
| Conjugate Type |
Random conjugation through nucleophilic lysines.
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| Combination Type |
Ravtansine
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