Antibody-drug Conjugate Information
General Information of This Antibody-drug Conjugate (ADC)
| ADC ID |
DRG0GRGXW
|
|||||
|---|---|---|---|---|---|---|
| ADC Name |
C-ADC
|
|||||
| Drug Status |
Investigative
|
|||||
| Indication |
In total 1 Indication(s)
|
|||||
| Drug-to-Antibody Ratio |
3.91
|
|||||
| Structure |
|
|||||
| Antibody Name |
Trastuzumab
|
Antibody Info | ||||
| Antigen Name |
Receptor tyrosine-protein kinase erbB-2 (HER2)
|
Antigen Info | ||||
| Payload Name |
Monomethyl auristatin E
|
Payload Info | ||||
| Therapeutic Target |
Microtubule (MT)
|
Target Info | ||||
| Linker Name |
Divinylpyrimidine-PEG4-Val-Ala-PABC
|
Linker Info | ||||
| Conjugate Type |
Reduction of the 4 interchain disulfides in a IgG1 is followed by treatment with a thiol-selective bis-reactive linker that can covalently cross-link the reduced cysteines.
|
|||||
