Antibody-drug Conjugate Information
General Information of This Antibody-drug Conjugate (ADC)
| ADC ID |
DRG0XPPOZ
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| ADC Name |
Vorsetuzumab mafodotin
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| Synonyms |
SGN-75; SGN75; SGN 75
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| Organization |
Seagen Inc.
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| Drug Status |
Terminated in phase 1
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| Indication |
In total 2 Indication(s)
Non Hodgkin lymphoma [ICD11:2B33]
Terminated in phase 1
Renal cell carcinoma [ICD11:2C90]
Terminated in phase 1
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| Drug-to-Antibody Ratio |
3-4
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| Structure |
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| Antibody Name |
Vorsetuzumab
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Antibody Info | ||||
| Antigen Name |
CD70 antigen (CD70)
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Antigen Info | ||||
| Payload Name |
Monomethyl auristatin F
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Payload Info | ||||
| Therapeutic Target |
Microtubule (MT)
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Target Info | ||||
| Linker Name |
Maleimido-caproyl
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Linker Info | ||||
| Conjugate Type |
Random conjugation through reduced inter-chain cysteines.
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| Combination Type |
Mafodotin
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| ChEBI ID | ||||||
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