Antibody-drug Conjugate Information
General Information of This Antibody-drug Conjugate (ADC)
| ADC ID |
DRG0RSBMJ
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| ADC Name |
Sofituzumab vedotin
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| Synonyms |
Anti-MUC16 monoclonal antibody MMAE; Anti-MUC16 monoclonal antibody monomethyl auristatin E conjugate; Anti-MUC16 monoclonal antibody vedotin; MMAE anti-MUC16; RG-7458; DMUC-5754A; MMAE anti-MUC16 mAb; Anti-MUC16 MMAE ADC; Anti-MUC16 mAb MMAE; Anti-MUC16 ADC MMAE; DMUC5754A
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| Organization |
Genentech, Inc.; Roche Holding AG
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| Drug Status |
Terminated in phase 1
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| Indication |
In total 4 Indication(s)
Fallopian tube cancer [ICD11:2C74]
Terminated in phase 1
Ovarian cancer [ICD11:2C73]
Terminated in phase 1
Pancreatic cancer [ICD11:2C10]
Terminated in phase 1
Peritoneal cancer [ICD11:2C51]
Terminated in phase 1
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| Drug-to-Antibody Ratio |
3.5
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| Structure |
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| Antibody Name |
Anti-MUC16 Anti-ody 3A5
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Antibody Info | ||||
| Antigen Name |
Mucin-16 (MUC16)
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Antigen Info | ||||
| Payload Name |
Monomethyl auristatin E
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Payload Info | ||||
| Therapeutic Target |
Microtubule (MT)
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Target Info | ||||
| Linker Name |
Mc-Val-Cit-PABC
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Linker Info | ||||
| Conjugate Type |
Random conjugation through reduced inter-chain cysteines.
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| Combination Type |
Vedotin
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| Puchem SID | ||||||
| Drugbank ID | ||||||
| ChEBI ID | ||||||
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