Antibody-drug Conjugate Information
General Information of This Antibody-drug Conjugate (ADC)
| ADC ID |
DRG0GYNBS
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| ADC Name |
XMT-1522
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| Synonyms |
TAK-522; XMT1522; XMT 1522; TAK 522; TAK522
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| Organization |
Mersana Therapeutics, Inc.; Adimab LLC; Takeda Pharmaceutical Co., Ltd.
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| Drug Status |
Terminated in phase 1
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| Indication |
In total 3 Indication(s)
Breast cancer [ICD11:2C60-2C65]
Terminated in phase 1
Gastric cancer [ICD11:2B72]
Terminated in phase 1
Non-small cell lung cancer [ICD11:2C25]
Terminated in phase 1
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| Drug-to-Antibody Ratio |
12
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| Antibody Name |
XMT-1519
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Antibody Info | ||||
| Antigen Name |
Receptor tyrosine-protein kinase erbB-2 (ERBB2)
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Antigen Info | ||||
| Payload Name |
Auristatin F hydroxypropylamide (AF-HPA)
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Payload Info | ||||
| Therapeutic Target |
Microtubule (MT)
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Target Info | ||||
| Linker Name |
Fleximer polymer
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Linker Info | ||||
| Conjugate Type |
Random conjugation through reduced inter-chain cysteines.
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| Combination Type |
Dolaflexin (containing 24 AF-HPA)
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| TTD ID | ||||||
General Information of The Activity Data Related to This ADC
Full List of Activity Data of This Antibody-drug Conjugate
Discovered Using Cell Line-derived Xenograft Model
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Tumor Growth Inhibition value (TGI) | ≈ 100.00% (Day 49) | Positive HER2 expression (HER2+++/++) | ||
| Method Description |
XMT-1522 (3 mg/kg, every seven days x3) induces efficient tumor cell killing in cell line-derived models of JIMT-1 cells with HER2 expression with high expression.
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| In Vivo Model | JIMT-1 CDX model | ||||
| In Vitro Model | Breast ductal carcinoma | JIMT-1 cells | CVCL_2077 | ||
References
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