Antibody-drug Conjugate Information
General Information of This Antibody-drug Conjugate (ADC)
| ADC ID |
DRG0FXION
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| ADC Name |
Anti-TrkB mAb 641 ADC
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| Synonyms |
Anti-TrkB mAb 641 ADC
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| Drug Status |
Investigative
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| Indication |
In total 2 Indication(s)
Breast cancer [ICD11:2C60-2C65]
Investigative
Triple negative breast cancer [ICD11:2C60-2C65]
Investigative
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| Drug-to-Antibody Ratio |
2
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| Structure |
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| Antibody Name |
Anti-TrkB mAb 641
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Antibody Info | ||||
| Antigen Name |
BDNF/NT-3 growth factors receptor (NTRK2)
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Antigen Info | ||||
| Payload Name |
Monomethyl auristatin F
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Payload Info | ||||
| Therapeutic Target |
Microtubule (MT)
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Target Info | ||||
| Linker Name |
Hexapeptide linker ASTKGP
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Linker Info | ||||
| Conjugate Type |
Site specific conjugating by catalyzing the naturally embedded lysine Lys99 in antibody.
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