Antibody-drug Conjugate Information
General Information of This Antibody-drug Conjugate (ADC)
| ADC ID |
DRG0HISTV
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| ADC Name |
AVE-9633
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| Synonyms |
Anti-CD33 TAP; Anti-CD33-DM4 immunoconjugate; huMy9-6-DM4; huMY96DM4; AVE 9633; IMGN-633; AVE9633
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| Organization |
ImmunoGen, Inc.; Sanofi
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| Drug Status |
Terminated in phase 1
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| Indication |
In total 1 Indication(s)
Acute myelogenous leukemia [ICD11:2B33]
Terminated in phase 1
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| Drug-to-Antibody Ratio |
3.5
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| Structure |
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| Antibody Name |
Anti-CD33 mAb huMy9-6
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Antibody Info | ||||
| Antigen Name |
Myeloid cell surface antigen CD33 (CD33)
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Antigen Info | ||||
| Payload Name |
Mertansine DM4
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Payload Info | ||||
| Therapeutic Target |
Microtubule (MT)
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Target Info | ||||
| Linker Name |
N-succinimidyl 4-(2-pyridyldithio) butanoate (SPDB)
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Linker Info | ||||
| Conjugate Type |
Random conjugation through nucleophilic lysines.
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| Combination Type |
Ravtansine
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| Puchem SID | ||||||
| Drugbank ID | ||||||
| ChEBI ID | ||||||
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