Antibody-drug Conjugate Information

General Information of This Antibody-drug Conjugate (ADC)

ADC ID	DRG0YJTCC
ADC Name	PeptibodyC19-PEG4-Val-Cit-MMAE
Synonyms	PeptibodyC19-PEG4-Val-Cit-MMAE Click to Show/Hide
Drug Status	Investigative
Indication	In total 1 Indication(s) Lung cancer [ICD11:2C25] Investigative
Drug-to-Antibody Ratio	4
	3D MOL	2D MOL
Antibody Name	Peptibody C19		Antibody Info
Antigen Name	Fibroblast growth factor receptor 1 (FGFR1)		Antigen Info
Payload Name	Monomethyl auristatin E		Payload Info
Therapeutic Target	Microtubule (MT)		Target Info
Linker Name	Mc-Val-Cit-PABC		Linker Info
Conjugate Type	Random conjugation through reduced inter-chain cysteines.
Combination Type	Vedotin

General Information of The Activity Data Related to This ADC

Revealed Based on the Cell Line Data

Click To Hide/Show 3 Activity Data Related to This Level

Standard Type	Value	Units	Cell Line	Disease Model
Half Maximal Effective Concentration (EC50)	4.55	nM	NCI-H1581 cells	Lung large cell carcinoma
Half Maximal Effective Concentration (EC50)	90.49	nM	NCI-H520 cells	Lung squamous cell carcinoma
Half Maximal Effective Concentration (EC50)	> 1000	nM	HCC95 cells	Lung squamous cell carcinoma

Full List of Activity Data of This Antibody-drug Conjugate

Revealed Based on the Cell Line Data

Click To Hide/Show 3 Activity Data Related to This Level

Experiment 1 Reporting the Activity Date of This ADC					[1]
Efficacy Data	Half Maximal Effective Concentration (EC50)	4.55 nM	High FGFR1 expression (FGFR1+++)
Method Description	Human lung cancer cell lines showing FGFR1 overexpression (NCI-H520 and NCI-H1581) was chosen and a cell line with physiological, low levels of FGFR1 (HCC95) was chosen as a control,.
In Vitro Model	Lung large cell carcinoma	NCI-H1581 cells		CVCL_1479
Experiment 2 Reporting the Activity Date of This ADC					[1]
Efficacy Data	Half Maximal Effective Concentration (EC50)	90.49 nM	High FGFR1 expression (FGFR1+++)
Method Description	Human lung cancer cell lines showing FGFR1 overexpression (NCI-H520 and NCI-H1581) was chosen and a cell line with physiological, low levels of FGFR1 (HCC95) was chosen as a control,.
In Vitro Model	Lung squamous cell carcinoma	NCI-H520 cells		CVCL_1566
Experiment 3 Reporting the Activity Date of This ADC					[1]
Efficacy Data	Half Maximal Effective Concentration (EC50)	> 1000.00 nM	Negative FGFR1 expression (FGFR1-)
Method Description	Human lung cancer cell lines showing FGFR1 overexpression (NCI-H520 and NCI-H1581) was chosen and a cell line with physiological, low levels of FGFR1 (HCC95) was chosen as a control,.
In Vitro Model	Lung squamous cell carcinoma	HCC95 cells		CVCL_5137

References

Ref 1	Drug Conjugation via Maleimide-Thiol Chemistry Does Not Affect Targeting Properties of Cysteine-Containing Anti-FGFR1 Peptibodies. Mol Pharm. 2022 May 2;19(5):1422-1433.