Antibody-drug Conjugate Information
General Information of This Antibody-drug Conjugate (ADC)
ADC ID |
DRG0RXAJR
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ADC Name |
Fcab-2-MMAE
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Synonyms |
Fcab-2 MMAE
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Drug Status |
Investigative
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Indication |
In total 2 Indication(s)
Breast cancer [ICD11:2C60-2C65]
Investigative
Epidermoid cancer [ICD11:XH4CR9]
Investigative
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Drug-to-Antibody Ratio |
2.7
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Structure | ||||||
Antibody Name |
Fcab-2
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Antibody Info | ||||
Antigen Name |
Epidermal growth factor receptor (EGFR)
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Antigen Info | ||||
Payload Name |
Monomethyl auristatin E
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Payload Info | ||||
Therapeutic Target |
Microtubule (MT)
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Target Info | ||||
Linker Name |
Gly3-Val-Cit-PABC
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Linker Info | ||||
Conjugate Type |
Fcab-2 was conjugated by an engineered microbial transglutaminase (mTG) targeting Q295, Q311 and Q438 with linker-payload.
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General Information of The Activity Data Related to This ADC
Revealed Based on the Cell Line Data
Full List of Activity Data of This Antibody-drug Conjugate
Revealed Based on the Cell Line Data
Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
Efficacy Data | Half Maximal Inhibitory Concentration (IC50) | 0.19±0.05 nM | High EGFR expression (EGFR+++/++) | ||
Method Description |
The inhibitory activity of Fcab-2-MMAE against cancer cell growth was evaluated in various human cancer cell lines in vitro.
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In Vitro Model | Breast adenocarcinoma | MDA-MB-468 cells | CVCL_0419 | ||
Experiment 2 Reporting the Activity Date of This ADC | [1] | ||||
Efficacy Data | Half Maximal Inhibitory Concentration (IC50) | > 100.00 nM | Negative EGFR expression (EGFR-) | ||
Method Description |
The inhibitory activity of Fcab-2-MMAE against cancer cell growth was evaluated in various human cancer cell lines in vitro.
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In Vitro Model | Invasive breast carcinoma | MCF-7 cells | CVCL_0031 | ||
Experiment 3 Reporting the Activity Date of This ADC | [2] | ||||
Efficacy Data | Half Maximal Effective Concentration (EC50) | 1.40 nM | Low FOLR1 expression (FOLR1+) | ||
Method Description |
The inhibitory activity of Fcab-2-MMAE against cancer cell growth was evaluated in various human cancer cell lines in vitro.
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In Vitro Model | Skin squamous cell carcinoma | A431 cells | CVCL_0037 |
References
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