Antibody-drug Conjugate Information
General Information of This Antibody-drug Conjugate (ADC)
| ADC ID |
DRG0JKRHR
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| ADC Name |
Alb-DMBA-SIL-MMAE
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| Synonyms |
Alb DMBA SIL MMAE
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| Drug Status |
Investigative
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| Indication |
In total 4 Indication(s)
Colon cancer [ICD11:2B90]
Investigative
Oral squamous cell carcinoma [ICD11:2B6E]
Investigative
Pancreatic cancer [ICD11:2C10]
Investigative
Thyroid cancer [ICD11:2D10]
Investigative
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| Drug-to-Antibody Ratio |
0.12
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| Structure |
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| Antibody Name |
Alb
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Antibody Info | ||||
| Antigen Name |
Albumin (ALB)
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Antigen Info | ||||
| Payload Name |
Monomethyl auristatin E
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Payload Info | ||||
| Therapeutic Target |
Microtubule (MT)
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Target Info | ||||
| Linker Name |
DMBA-SIL
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Linker Info | ||||
| Conjugate Type |
Maleimide selectively reacts with free thiol at Cys 34 on Alb, Michael addition.
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General Information of The Activity Data Related to This ADC
Revealed Based on the Cell Line Data
Full List of Activity Data of This Antibody-drug Conjugate
Revealed Based on the Cell Line Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal Inhibitory Concentration (IC50) |
0.76 nM
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| Method Description |
The inhibitory activity of Alb-DMBA-SIL-MMAE against cancer cell growth was evaluated in various human cancer cell lines in vitro. Caged and conjugated MMAE is selectively cytotoxic and activated by X-ray irradiation.
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| In Vitro Model | Thyroid gland anaplastic carcinoma | 8505C cells | CVCL_1054 | ||
| Experiment 2 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal Inhibitory Concentration (IC50) |
2.00 nM
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| Method Description |
The inhibitory activity of Alb-DMBA-SIL-MMAE against cancer cell growth was evaluated in various human cancer cell lines in vitro. Caged and conjugated MMAE is selectively cytotoxic and activated by X-ray irradiation.
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| In Vitro Model | Mouse colon adenocarcinoma | MC-38 cells | CVCL_B288 | ||
| Experiment 3 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal Inhibitory Concentration (IC50) | 7.29 nM | Low FOLR1 expression (FOLR1+) | ||
| Method Description |
The inhibitory activity of Alb-DMBA-SIL-MMAE against cancer cell growth was evaluated in various human cancer cell lines in vitro. Caged and conjugated MMAE is selectively cytotoxic and activated by X-ray irradiation.
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| In Vitro Model | Acute erythroid leukemia | TBP-3743 cancer cells | Mus musculus | ||
| Experiment 4 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal Inhibitory Concentration (IC50) |
8.92 nM
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| Method Description |
The inhibitory activity of Alb-DMBA-SIL-MMAE against cancer cell growth was evaluated in various human cancer cell lines in vitro. Caged and conjugated MMAE is selectively cytotoxic and activated by X-ray irradiation.
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| In Vitro Model | Oral cavity squamous cell carcinoma | MOC-L2 cells | CVCL_A9X4 | ||
| Experiment 5 Reporting the Activity Date of This ADC | [2] | ||||
| Efficacy Data | Half Maximal Effective Concentration (EC50) |
1.40 nM
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| Method Description |
The inhibitory activity of Alb-DMBA-SIL-MMAE against cancer cell growth was evaluated in various human cancer cell lines in vitro. Caged and conjugated MMAE is selectively cytotoxic and activated by X-ray irradiation.
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| In Vitro Model | Skin squamous cell carcinoma | A431 cells | CVCL_0037 | ||
References
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