Antibody-drug Conjugate Information
General Information of This Antibody-drug Conjugate (ADC)
| ADC ID |
DRG0AVQWJ
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| ADC Name |
BAT-8003
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| Synonyms |
Anti-Trop-2 ADC; Anti-Trop-2 antibody-drug conjugate; BAT8003; BAT 8003
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| Organization |
Bio-Thera Solutions, Ltd.
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| Drug Status |
Terminated in phase 1
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| Indication |
In total 3 Indication(s)
Bladder cancer [ICD11:2C94]
Terminated in phase 1
Metastatic breast cancer [ICD11:2C6Y]
Terminated in phase 1
Non-small cell lung cancer [ICD11:2C25]
Terminated in phase 1
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| Drug-to-Antibody Ratio |
3.5
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| Antibody Name |
Undisclosed
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| Antigen Name |
Tumor-associated calcium signal transducer 2 (TACSTD2)
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Antigen Info | ||||
| Payload Name |
Maytansinoid derivative
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Payload Info | ||||
| Therapeutic Target |
Microtubule (MT)
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Target Info | ||||
| Linker Name |
Uncleavable linker
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Linker Info | ||||
| Conjugate Type |
Site-specific conjugation through the engineered cysteine (THIOMAB, Cys114).
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| Combination Type |
Batansine
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General Information of The Activity Data Related to This ADC
Identified from the Human Clinical Data
Full List of Activity Data of This Antibody-drug Conjugate
Identified from the Human Clinical Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Related Clinical Trial | |||||
| NCT Number | NCT03884517 | Clinical Status | Phase 1 | ||
| Clinical Description | An open, escalating phase 1 clinical trial of BAT8003 (for injection) on the safety, tolerability and pharmacokinetics for patients with advanced epithelial cancer. | ||||
References
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