Antibody-drug Conjugate Information
General Information of This Antibody-drug Conjugate (ADC)
| ADC ID |
DRG0TOHWK
|
|||||
|---|---|---|---|---|---|---|
| ADC Name |
T-N-F (DAR 3.2)
|
|||||
| Synonyms |
T-N-F DAR 3.2
Click to Show/Hide
|
|||||
| Drug Status |
Investigative
|
|||||
| Indication |
In total 1 Indication(s)
|
|||||
| Drug-to-Antibody Ratio |
3.2
|
|||||
| Structure |
|
|||||
| Antibody Name |
Trastuzumab
|
Antibody Info | ||||
| Antigen Name |
Receptor tyrosine-protein kinase erbB-2 (HER2)
|
Antigen Info | ||||
| Payload Name |
Aldehyde-tagged MMAF
|
Payload Info | ||||
| Therapeutic Target |
Microtubule (MT)
|
Target Info | ||||
| Linker Name |
Undisclosed
|
|||||
| Conjugate Type |
Conjugate synthesized via N-terminal conjugation method (NTERM) conjugation, conjugates cytotoxic drugs to the N-termini of an antibody through amine bond via reductive alkylation reaction.
|
|||||
