Antibody-drug Conjugate Information

General Information of This Antibody-drug Conjugate (ADC)
ADC ID
DRG0VBCHH
ADC Name
muFR1-21-PEG4-Mal-DM4
Synonyms
muFR1 21 PEG4 Mal DM4
   Click to Show/Hide
Organization
ImmunoGen, Inc.
Drug Status
Investigative
Indication
In total 2 Indication(s)
Cervical cancer [ICD11:2C77]
Investigative
Ovarian cancer [ICD11:2C73]
Investigative
Drug-to-Antibody Ratio
3.5-4
Structure
Antibody Name
mu-FR1-21
  Antibody Info 
Antigen Name
Folate receptor alpha (FOLR1)
  Antigen Info 
Payload Name
Mertansine DM4
  Payload Info 
Therapeutic Target
Microtubule (MT)
  Target Info 
Linker Name
PEG4-Mal
  Linker Info 
Conjugate Type
Random conjugation through nucleophilic lysines.
General Information of The Activity Data Related to This ADC
Revealed Based on the Cell Line Data
Click To Hide/Show 1 Activity Data Related to This Level
Standard Type Value Units Cell Line Disease Model
Half Maximal Inhibitory Concentration (IC50) 
0.1
nM
SK-OV-3 cells
Ovarian serous cystadenocarcinoma
Full List of Activity Data of This Antibody-drug Conjugate
Revealed Based on the Cell Line Data
Click To Hide/Show 1 Activity Data Related to This Level
Experiment 1 Reporting the Activity Date of This ADC [1]
Efficacy Data Half Maximal Inhibitory Concentration (IC50) 0.10 nM Positive FOLR1 expression (FOLR1 +++/++)
Method Description
FOLR1-expressing SKOV3 cells were incubated with varying concentrations of anti FOLR1 antibodies or their conjugates and processed.
In Vitro Model Ovarian serous cystadenocarcinoma SK-OV-3 cells CVCL_0532
References
Ref 1 Folate receptor 1 antibodies and immunoconjugates and uses thereof; 2011-09-01.

If you find any error in data or bug in web service, please kindly report it to Dr. Shen et al.