Antibody-drug Conjugate Information

General Information of This Antibody-drug Conjugate (ADC)

ADC ID	DRG0EZOEW
ADC Name	1F6-Met-Lys-AF
Drug Status	Investigative
Indication	In total 2 Indication(s) Hodgkin lymphoma [ICD11:2B30] Investigative Renal cell carcinoma [ICD11:2C90] Investigative
Structure
	3D MOL	2D MOL
Antibody Name	Anti-CD70 mAb IF6		Antibody Info
Antigen Name	CD70 antigen (CD70)		Antigen Info
Payload Name	Auristatin F		Payload Info
Therapeutic Target	Microtubule (MT)		Target Info
Linker Name	Mal-Met-Lys		Linker Info

General Information of The Activity Data Related to This ADC

Revealed Based on the Cell Line Data

Click To Hide/Show 3 Activity Data Related to This Level

Standard Type	Value	Units	Cell Line	Disease Model
Half Maximal Inhibitory Concentration (IC50)	3	ng/mL	L-428 cells	Hodgkin lymphoma
Half Maximal Inhibitory Concentration (IC50)	4	ng/mL	Caki-1 cells	Clear cell renal cell carcinoma
Half Maximal Inhibitory Concentration (IC50)	7	ng/mL	786-O cells	Renal cell carcinoma

Full List of Activity Data of This Antibody-drug Conjugate

Revealed Based on the Cell Line Data

Click To Hide/Show 3 Activity Data Related to This Level

Experiment 1 Reporting the Activity Date of This ADC					[1]
Efficacy Data	Half Maximal Inhibitory Concentration (IC50)	3.00 ng/mL	Positive CD70 expression (CD70+++/++)
Method Description	IC50 values are the mean and SD of 21 independent experimental titrations, each performed at least in duplicate.
In Vitro Model	Hodgkin lymphoma	L-428 cells		CVCL_1361
Experiment 2 Reporting the Activity Date of This ADC					[1]
Efficacy Data	Half Maximal Inhibitory Concentration (IC50)	4.00 ng/mL	Positive CD70 expression (CD70+++/++)
Method Description	IC50 values are the mean and SD of 21 independent experimental titrations, each performed at least in duplicate.
In Vitro Model	Clear cell renal cell carcinoma	Caki-1 cells		CVCL_0234
Experiment 3 Reporting the Activity Date of This ADC					[1]
Efficacy Data	Half Maximal Inhibitory Concentration (IC50)	7.00 ng/mL	Positive CD70 expression (CD70+++/++)
Method Description	IC50 values are the mean and SD of 21 independent experimental titrations, each performed at least in duplicate.
In Vitro Model	Renal cell carcinoma	786-O cells		CVCL_1051

References

Ref 1	Novel Peptide Linkers for Highly Potent Antibody-Auristatin Conjugate.