Antibody-drug Conjugate Information
General Information of This Antibody-drug Conjugate (ADC)
| ADC ID |
DRG0WWTYN
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| ADC Name |
Anti-EGFR-PEG4-Mal-DM1
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| Synonyms |
Anti-EGFR monoclonal antibody-DM1 conjugate; AntiEGFR DM1
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| Organization |
ImmunoGen, Inc.
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| Drug Status |
Clinical candidate
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| Indication |
In total 2 Indication(s)
Colorectal cancer [ICD11:2B91]
Clinical candidate
Kidney cancer [ICD11:2C90]
Clinical candidate
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| Structure |
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| Antibody Name |
Anti-EGFR mAb rat IgG2a
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Antibody Info | ||||
| Antigen Name |
Epidermal growth factor receptor (EGFR)
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Antigen Info | ||||
| Payload Name |
Mertansine DM1
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Payload Info | ||||
| Therapeutic Target |
Microtubule (MT)
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Target Info | ||||
| Linker Name |
PEG4-Mal
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Linker Info | ||||
| Conjugate Type |
The succinimide of linker randomly reacts with the free amino groups of lysine residues in mab, forming a stable amide bond.
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