Antibody-drug Conjugate Information
General Information of This Antibody-drug Conjugate (ADC)
| ADC ID |
DRG0WSFBE
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| ADC Name |
Alpha-CD70-Mc-MMAF
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| Synonyms |
AlphaCD70 mcMMAF
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| Organization |
Oxford BioTherapeutics Ltd.; Seagen Inc.
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| Drug Status |
Terminated
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| Indication |
In total 2 Indication(s)
Hodgkin lymphoma [ICD11:2B30]
Terminated
Multiple myeloma [ICD11:2A83]
Terminated
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| Drug-to-Antibody Ratio |
4
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| Structure |
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| Antibody Name |
Chimeric Anti-CD70 Anti-ody
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Antibody Info | ||||
| Antigen Name |
CD70 antigen (CD70)
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Antigen Info | ||||
| Payload Name |
Monomethyl auristatin E
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Payload Info | ||||
| Therapeutic Target |
Microtubule (MT)
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Target Info | ||||
| Linker Name |
Mc-Val-Cit-PABC
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Linker Info | ||||
| Conjugate Type |
Random conjugation through reduced inter-chain cysteines.
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| Combination Type |
Vedotin
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