Antibody-drug Conjugate Information
General Information of This Antibody-drug Conjugate (ADC)
| ADC ID |
DRG0UEVWF
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| ADC Name |
Anti-TenB2 antibody drug conjugate
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| Synonyms |
Anti-TenB2 antibody drug conjugate (Genentech)
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| Organization |
Genentech, Inc.; Roche Holding AG
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| Drug Status |
Terminated
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| Indication |
In total 1 Indication(s)
Prostate cancer [ICD11:2C82]
Terminated
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| Drug-to-Antibody Ratio |
1.8-2.0
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| Structure |
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| Antibody Name |
Anti-TENB2 monoclonal Anti-ody (mAb)
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Antibody Info | ||||
| Antigen Name |
Tomoregulin-2 (TMEFF2)
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Antigen Info | ||||
| Payload Name |
Monomethyl auristatin E
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Payload Info | ||||
| Therapeutic Target |
Microtubule (MT)
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Target Info | ||||
| Linker Name |
Mc-Val-Cit-PABC
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Linker Info | ||||
| Conjugate Type |
Random conjugation through reduced inter-chain cysteines.
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| Combination Type |
Vedotin
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