Antibody-drug Conjugate Information
General Information of This Antibody-drug Conjugate (ADC)
| ADC ID |
DRG0ORORL
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| ADC Name |
LCB-ADC2
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| Synonyms |
LCB ADC2
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| Drug Status |
Investigative
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| Indication |
In total 2 Indication(s)
Breast cancer [ICD11:2C60-2C65]
Investigative
Gastric cancer [ICD11:2B72]
Investigative
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| Drug-to-Antibody Ratio |
4
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| Antibody Name |
Isoprenylated trastuzumab
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Antibody Info | ||||
| Antigen Name |
Receptor tyrosine-protein kinase erbB-2 (ERBB2)
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Antigen Info | ||||
| Payload Name |
Monomethyl auristatin F
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Payload Info | ||||
| Therapeutic Target |
Microtubule (MT)
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Target Info | ||||
| Linker Name |
Isoprene-PEG3,3,3-beta-Glu-PABC
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Linker Info | ||||
| Conjugate Type |
Bonding between the SH on the Cys residue of CaaX, which was added the end of the antibody (light chain and/or heavy chain), and the pyrophosphate of isoprenoid (farnesyl pyrophosphate) can then be generated by FTase.
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