Antibody-drug Conjugate Information
General Information of This Antibody-drug Conjugate (ADC)
| ADC ID |
DRG0KJEVJ
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| ADC Name |
Anti-HER2 scFv-Fc (Ser396Sec)-CN29
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| Synonyms |
Selenomab-Drug Conjugates (Scripps Research Institute)
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| Organization |
Scripps Florida Funding Corp.
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| Drug Status |
Investigative
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| Indication |
In total 1 Indication(s)
Solid tumors [ICD11:2A00-2A0Z|2B50-2F9Z]
Investigative
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| Drug-to-Antibody Ratio |
2
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| Structure |
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| Antibody Name |
Anti-HER2 scFv-Fc (Ser396Sec)
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Antibody Info | ||||
| Antigen Name |
Receptor tyrosine-protein kinase erbB-2 (ERBB2)
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Antigen Info | ||||
| Payload Name |
Monomethyl auristatin F derivative peptide (CN29)
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Payload Info | ||||
| Therapeutic Target |
Microtubule (MT)
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Target Info | ||||
| Linker Name |
Lodoacetamido-caproyl
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Linker Info | ||||
| Conjugate Type |
Serine 396 (Kabat numbering) was substituted to Sec (Ser396Sec), small molecules can be selectively conjugated to engineered C -terminal Sec residues.
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