Antibody-drug Conjugate Information
General Information of This Antibody-drug Conjugate (ADC)
| ADC ID |
DRG0VYKSA
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| ADC Name |
LM-305
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| Synonyms |
LM 305; LM-305; LM305; AZD-0305; AZD 0305; AZD0305
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| Organization |
LaNova Medicines Ltd.; AstraZeneca PLC
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| Drug Status |
Phase 1/2
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| Indication |
In total 1 Indication(s)
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| Drug-to-Antibody Ratio |
4
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| Antibody Name |
Undisclosed
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| Antigen Name |
G-protein coupled receptor family C group 5 member D (GPRC5D)
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Antigen Info | ||||
| Payload Name |
Monomethyl auristatin E
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Payload Info | ||||
| Therapeutic Target |
Microtubule (MT)
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Target Info | ||||
| Linker Name |
Mc-Val-Cit-PABC
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Linker Info | ||||
| Conjugate Type |
Undisclosed
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| Combination Type |
vedotin
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General Information of The Activity Data Related to This ADC
Discovered Using Cell Line-derived Xenograft Model
| Standard Type | Value | Units | Cell Line | Disease Model |
|---|---|---|---|---|
| Tumor Growth Inhibition value (TGI) |
≈ 100
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%
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Multiple myeloma cells
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Multiple myeloma
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Revealed Based on the Cell Line Data
Full List of Activity Data of This Antibody-drug Conjugate
Discovered Using Cell Line-derived Xenograft Model
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Tumor Growth Inhibition value (TGI) | ≈ 100.00% | High GPRC5D expression (GPRC5D+++) | ||
| Method Description |
The inhibitory activity of LM-305 against cancer cell growth was evaluated in Multiple myeloma CDX model in vivo. The dose of LM-305 was 3 mg/kg.
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| In Vivo Model | Multiple myeloma CDX model | ||||
| In Vitro Model | Multiple myeloma | Multiple myeloma cells | Homo sapiens | ||
Revealed Based on the Cell Line Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal Inhibitory Concentration (IC50) | 0.10-0.30 nM | High GPRC5D expression (GPRC5D+++) | ||
| Method Description |
LM-305 was evaluated in vitro for its cytotoxic activity against a panel of multiple myeloma cell lines. LM-305 was co-cultured with multiple myeloma cells.
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| In Vitro Model | Plasma cell myeloma | NCI-H929 cells | CVCL_1600 | ||
| Experiment 2 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal Inhibitory Concentration (IC50) | 0.10-0.30 nM | High GPRC5D expression (GPRC5D+++) | ||
| Method Description |
LM-305 was evaluated in vitro for its cytotoxic activity against a panel of multiple myeloma cell lines. LM-305 was co-cultured with multiple myeloma cells.
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| In Vitro Model | Plasma cell myeloma | MM1.R cells | CVCL_8794 | ||
References