General Information of This Antibody-drug Conjugate (ADC)
ADC ID
DRG0PXYTA
ADC Name
MEDI-4276
Synonyms
MEDI4276; MEDI 4276
   Click to Show/Hide
Organization
MedImmune LLC; AstraZeneca PLC
Drug Status
Terminated in phase 1
Indication
In total 2 Indication(s)
Breast cancer [ICD11:2C60-2C65]
Terminated in phase 1
Gastric cancer [ICD11:2B72]
Terminated in phase 1
Drug-to-Antibody Ratio
4
Structure
Antibody Name
MEDI-4276
 Antibody Info 
Antigen Name
Receptor tyrosine-protein kinase erbB-2 (HER2 ECD2); Receptor tyrosine-protein kinase erbB-2 (HER2 ECD4)
 Antigen Info 
Payload Name
AZ13599185
 Payload Info 
Therapeutic Target
Microtubule (MT)
 Target Info 
Linker Name
Maleimido-caproyl based linker
 Linker Info 
Conjugate Type
Site-specific conjugation through the engineered cysteine (THIOMAB, HC-Cys 239 and 442).
Puchem SID
472419624 , 404719837
ChEBI ID
CHEMBL4298032

If you find any error in data or bug in web service, please kindly report it to Dr. Shen et al.