Antibody-drug Conjugate Information
General Information of This Antibody-drug Conjugate (ADC)
| ADC ID |
DRG0CNRDW
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| ADC Name |
CD4-Val-Cit-MMAE
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| Synonyms |
CD4 Val Cit MMAE
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| Drug Status |
Investigative
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| Indication |
In total 1 Indication(s)
Mature T-cell lymphoma [ICD11:2A90]
Investigative
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| Antibody Name |
Anti-CD4 mAb
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Antibody Info | ||||
| Antigen Name |
T-cell surface glycoprotein CD4 (CD4)
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Antigen Info | ||||
| Payload Name |
Monomethyl auristatin E
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Payload Info | ||||
| Therapeutic Target |
Microtubule (MT)
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Target Info | ||||
| Linker Name |
Mc-Val-Cit-PABC
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Linker Info | ||||
| Conjugate Type |
Random conjugation through reduced inter-chain cysteines.
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| Combination Type |
Vedotin
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General Information of The Activity Data Related to This ADC
Revealed Based on the Cell Line Data
Full List of Activity Data of This Antibody-drug Conjugate
Revealed Based on the Cell Line Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal Inhibitory Concentration (IC50) | 18.00 nM | Positive CD4 expression (CD4 +++/++) | ||
| Method Description |
Receptors (R2) as a function of ADC concentrations, upon incubation with the antibody and following additional 48 h.
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| In Vitro Model | Adult T acute lymphoblastic leukemia | MOLT-4 cells | CVCL_0013 | ||
| Experiment 2 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal Inhibitory Concentration (IC50) | 22.00 nM | Positive CD4 expression (CD4 +++/++) | ||
| Method Description |
Receptors (R1) as a function of ADC concentrations, upon incubation with the antibody and following additional 48 h.
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| In Vitro Model | Adult T acute lymphoblastic leukemia | MOLT-4 cells | CVCL_0013 | ||
| Experiment 3 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal Inhibitory Concentration (IC50) | 40.00 nM | Positive CD4 expression (CD4 +++/++) | ||
| Method Description |
Receptors (R4) as a function of ADC concentrations, upon incubation with the antibody and following additional 48 h.
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| In Vitro Model | Adult T acute lymphoblastic leukemia | MOLT-4 cells | CVCL_0013 | ||
References
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