Antibody-drug Conjugate Information
General Information of This Antibody-drug Conjugate (ADC)
| ADC ID |
DRG0XODQO
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| ADC Name |
MF-BTX-MMAE
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| Synonyms |
MF BTX MMAE
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| Drug Status |
Investigative
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| Indication |
In total 1 Indication(s)
Anaplastic large cell lymphoma [ICD11:2A90]
Investigative
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| Drug-to-Antibody Ratio |
4
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| Structure |
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| Antibody Name |
Brentuximab
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Antibody Info | ||||
| Antigen Name |
Tumor necrosis factor receptor superfamily member 8 (TNFRSF8)
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Antigen Info | ||||
| Payload Name |
Monomethyl auristatin E
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Payload Info | ||||
| Therapeutic Target |
Microtubule (MT)
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Target Info | ||||
| Linker Name |
Dibromomethyl pyridine-Val-Cit-PABC
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Linker Info | ||||
| Conjugate Type |
After complete reduction of interchain disulfide bonds using TCEP-HCl, the linker incorporating McSAF (new technology based on a trifunctionalized di(bromomethyl)pyridine scaffold) inside technology was bioconjugated.
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