Antibody-drug Conjugate Information

General Information of This Antibody-drug Conjugate (ADC)

ADC ID	DRG0YTJMR
ADC Name	scFvF7-Fc-vcMMAE
Synonyms	scFvF7-Fc-Val-Cit-MMAE Click to Show/Hide
Drug Status	Investigative
Indication	In total 2 Indication(s) Caecum adenocarcinoma [ICD11:2B90] Investigative Gastric cancer [ICD11:2B72] Investigative
Drug-to-Antibody Ratio	4
	3D MOL	2D MOL
Antibody Name	Anti-FGFR2 scFv ECD_FGFR2		Antibody Info
Antigen Name	Fibroblast growth factor receptor 2 (FGFR2)		Antigen Info
Payload Name	Monomethyl auristatin E		Payload Info
Therapeutic Target	Microtubule (MT)		Target Info
Linker Name	Mc-Val-Cit-PABC		Linker Info
Conjugate Type	Random conjugation through reduced inter-chain cysteines.
Combination Type	Vedotin

General Information of The Activity Data Related to This ADC

Revealed Based on the Cell Line Data

Click To Hide/Show 2 Activity Data Related to This Level

Standard Type	Value	Units	Cell Line	Disease Model
Half Maximal Inhibitory Concentration (IC50)	0.89	nM	SNU-16 cells	Gastric adenocarcinoma
Half Maximal Inhibitory Concentration (IC50)	7.7	nM	NCI-H716 cells	Cecum adenocarcinoma

Full List of Activity Data of This Antibody-drug Conjugate

Revealed Based on the Cell Line Data

Click To Hide/Show 2 Activity Data Related to This Level

Experiment 1 Reporting the Activity Date of This ADC					[1]
Efficacy Data	Half Maximal Inhibitory Concentration (IC50)	0.89 nM	Positive FGFR2 expression (FGFR2+++/++)
Method Description	SNU-16, NCI-H716 and U2OS cells were seeded at a density of 5000 cells per well in a 96-well culture plate and treated with vcMMAE, scFvF7-Fc, or antibody-vcMMAE conjugate scFvF7-Fc-MMAE for 96 hours.
In Vitro Model	Gastric adenocarcinoma	SNU-16 cells		CVCL_0076
Experiment 2 Reporting the Activity Date of This ADC					[1]
Efficacy Data	Half Maximal Inhibitory Concentration (IC50)	7.70 nM	Positive FGFR2 expression (FGFR2+++/++)
Method Description	SNU-16, NCI-H716 and U2OS cells were seeded at a density of 5000 cells per well in a 96-well culture plate and treated with vcMMAE, scFvF7-Fc, or antibody-vcMMAE conjugate scFvF7-Fc-MMAE for 96 hours.
In Vitro Model	Cecum adenocarcinoma	NCI-H716 cells		CVCL_1581

References

Ref 1	Generation of high-affinity, internalizing anti-FGFR2 single-chain variable antibody fragment fused with Fc for targeting gastrointestinal cancers. PLoS One. 2018 Feb 8;13(2):e0192194. doi: 10.1371/journal.pone.0192194. eCollection 2018.