Antibody-drug Conjugate Information
General Information of This Antibody-drug Conjugate (ADC)
| ADC ID |
DRG0HEEGF
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| ADC Name |
hu4DFabv8 (V110C)-MC-Val-Cit-PAB-MMAF
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| Synonyms |
hu4DFabv8 (V110C)-vcMMAF
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| Organization |
Genentech, Inc.
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| Drug Status |
Investigative
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| Indication |
In total 1 Indication(s)
Breast cancer [ICD11:2C60-2C65]
Investigative
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| Drug-to-Antibody Ratio |
3.6
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| Antibody Name |
hu4DFabv8 (V110C)
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Antibody Info | ||||
| Antigen Name |
Receptor tyrosine-protein kinase erbB-2 (ERBB2)
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Antigen Info | ||||
| Payload Name |
Monomethyl auristatin F
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Payload Info | ||||
| Therapeutic Target |
Microtubule (MT)
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Target Info | ||||
| Linker Name |
Mc-Val-Cit-PABC
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Linker Info | ||||
| Conjugate Type |
Random conjugation through reduced inter-chain cysteines.
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| Combination Type |
vcMMAF
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