Antibody-drug Conjugate Information
General Information of This Antibody-drug Conjugate (ADC)
| ADC ID |
DRG0MVDEN
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| ADC Name |
DAR8-alphaCD30-mDPR-GlucQ-Tub
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| Synonyms |
DAR8 alphaCD30 mDPR glucQ Tub
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| Organization |
Seagen Inc.
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| Drug Status |
Clinical candidate
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| Indication |
In total 1 Indication(s)
Hodgkin lymphoma [ICD11:2B30]
Clinical candidate
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| Drug-to-Antibody Ratio |
8
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| Structure |
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| Antibody Name |
Anti-CD30 DAR8-alphaCD30-mDPR-glucQ-Tub mAb
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Antibody Info | ||||
| Antigen Name |
Tumor necrosis factor receptor superfamily member 8 (TNFRSF8)
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Antigen Info | ||||
| Payload Name |
Tubulysin analogue 3
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Payload Info | ||||
| Therapeutic Target |
Microtubule (MT)
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Target Info | ||||
| Linker Name |
Quaternary ammonium linker GlucQ
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Linker Info | ||||
| Conjugate Type |
A self-stabilizing maleimide (mDPR) was utilized as the point of attachment for antibody conjugation.
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| Combination Type |
GlucQ-Tub
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