Antibody-drug Conjugate Information
General Information of This Antibody-drug Conjugate (ADC)
| ADC ID |
DRG0LXXFO
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| ADC Name |
BVD-TEM8 ADC
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| Synonyms |
BVD TEM8 ADC; BVDTEM8 ADC; m825-MMAE
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| Organization |
BioMed Valley Discoveries, Inc.
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| Drug Status |
Clinical candidate
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| Indication |
In total 5 Indication(s)
Breast cancer [ICD11:2C60-2C65]
Clinical candidate
Colon cancer [ICD11:2B90]
Clinical candidate
Lung cancer [ICD11:2C25]
Clinical candidate
Ovarian cancer [ICD11:2C73]
Clinical candidate
Pancreatic cancer [ICD11:2C10]
Clinical candidate
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| Drug-to-Antibody Ratio |
4
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| Structure |
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| Antibody Name |
Anti-TEM8 mAb m825
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Antibody Info | ||||
| Antigen Name |
Anthrax toxin receptor 1 (ANTXR1)
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Antigen Info | ||||
| Payload Name |
Monomethyl auristatin E
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Payload Info | ||||
| Therapeutic Target |
Microtubule (MT)
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Target Info | ||||
| Linker Name |
Mc-Val-Cit-PABC
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Linker Info | ||||
| Conjugate Type |
Random conjugation through reduced inter-chain cysteines.
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| Combination Type |
Vedotin
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