Antibody-drug Conjugate Information
General Information of This Antibody-drug Conjugate (ADC)
| ADC ID |
DRG0ZRBOR
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| ADC Name |
Anti-HER2 DVD-IgG1-Tiancimycin
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| Synonyms |
Tiancimycin-based antibody-drug conjugate (Scripps Research Institute)
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| Organization |
The Scripps Research Institute
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| Drug Status |
Investigative
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| Indication |
In total 1 Indication(s)
Breast cancer [ICD11:2C60-2C65]
Investigative
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| Drug-to-Antibody Ratio |
2
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| Structure |
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| Antibody Name |
Anti-HER2 DVD-IgG1
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Antibody Info | ||||
| Antigen Name |
Receptor tyrosine-protein kinase erbB-2 (ERBB2)
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Antigen Info | ||||
| Payload Name |
Tiancimycin
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Payload Info | ||||
| Therapeutic Target |
Microtubule (MT)
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Target Info | ||||
| Linker Name |
DVD-PEG4-Triazol
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Linker Info | ||||
| Conjugate Type |
The TNM-based payloads were conjugated to anti-HER2 DVD-IgG1, via a site-specific conjugation between the engineered Lys and the beta-lactam moiety of the varying linkers.
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