Antibody-drug Conjugate Information
General Information of This Antibody-drug Conjugate (ADC)
| ADC ID |
DRG0PAJCW
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| ADC Name |
CDX3379-MMAE
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| Synonyms |
CDX3379 MMAE
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| Drug Status |
Investigative
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| Indication |
In total 3 Indication(s)
Colon cancer [ICD11:2B90]
Investigative
Lewis lung cancer [ICD11:2C25]
Investigative
Melanoma [ICD11:2C30]
Investigative
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| Drug-to-Antibody Ratio |
4
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| Structure |
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| Antibody Name |
CDX3379
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Antibody Info | ||||
| Antigen Name |
Receptor tyrosine-protein kinase erbB-3 (ERBB3)
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Antigen Info | ||||
| Payload Name |
Monomethyl auristatin E
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Payload Info | ||||
| Therapeutic Target |
Microtubule (MT)
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Target Info | ||||
| Linker Name |
Mc-Val-Cit-PABC
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Linker Info | ||||
| Conjugate Type |
Random conjugation through reduced inter-chain cysteines.
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| Combination Type |
Vedotin
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