Antibody-drug Conjugate Information
General Information of This Antibody-drug Conjugate (ADC)
| ADC ID |
DRG0ERYUF
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| ADC Name |
SGN-B7H4V
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| Synonyms |
SGN-B7H4V; SGNB 7H4V; SGNB7H4V
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| Organization |
Seagen Inc.
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| Drug Status |
Phase 1
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| Indication |
In total 10 Indication(s)
Cholangiocarcinoma [ICD11:2C12]
Phase 1
Endometrial cancer [ICD11:2C76]
Phase 1
Fallopian tube cancer [ICD11:2C74]
Phase 1
Gallbladder cancer [ICD11:2C13]
Phase 1
HER2(+) breast cancer [ICD11:2C60-2C65]
Phase 1
HER2(-) breast cancer [ICD11:2C60-2C65]
Phase 1
Non-small cell lung cancer [ICD11:2C25]
Phase 1
Ovarian cancer [ICD11:2C73]
Phase 1
Peritoneal cancer [ICD11:2C51]
Phase 1
Triple negative breast cancer [ICD11:2C60-2C65]
Phase 1
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| Drug-to-Antibody Ratio |
4
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| Structure |
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| Antibody Name |
Humanized Anti-B7-H4 SGNB7H4V mAb
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Antibody Info | ||||
| Antigen Name |
V-set domain-containing T-cell activation inhibitor 1 (VTCN1)
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Antigen Info | ||||
| Payload Name |
Monomethyl auristatin E
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Payload Info | ||||
| Therapeutic Target |
Microtubule (MT)
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Target Info | ||||
| Linker Name |
Mc-Val-Cit-PABC
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Linker Info | ||||
| Conjugate Type |
Random conjugation through reduced inter-chain cysteines.
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| Combination Type |
Vedotin
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General Information of The Activity Data Related to This ADC
Full List of Activity Data of This Antibody-drug Conjugate
Identified from the Human Clinical Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Patients Enrolled |
Locally advanced unresectable or metastatic solid tumors.
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| Administration Dosage |
.
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| Related Clinical Trial | |||||
| NCT Number | NCT05194072 | Clinical Status | Phase 1 | ||
| Clinical Description | A phase 1 study of SGN-B7H4V in advanced solid tumors. | ||||
References
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