Antibody-drug Conjugate Information

General Information of This Antibody-drug Conjugate (ADC)
ADC ID
DRG0RITMD
ADC Name
Anti-alpha10-SAP
Synonyms
Anti-alpha10 Saporin
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Drug Status
Investigative
Indication
In total 1 Indication(s)
Glioblastoma [ICD11:2A00]
Investigative
Antibody Name
Anti-integrin alpha10 mAb
  Antibody Info 
Antigen Name
Integrin alpha-10 (ITGA10)
  Antigen Info 
Payload Name
Saporin
  Payload Info 
Therapeutic Target
Microtubule (MT)
  Target Info 
Linker Name
Undisclosed
General Information of The Activity Data Related to This ADC
Revealed Based on the Cell Line Data
Click To Hide/Show 1 Activity Data Related to This Level
Standard Type Value Units Cell Line Disease Model
Half Maximal Inhibitory Concentration (IC50) 
69
nM
U3046MG cells
Glioblastoma
Full List of Activity Data of This Antibody-drug Conjugate
Revealed Based on the Cell Line Data
Click To Hide/Show 1 Activity Data Related to This Level
Experiment 1 Reporting the Activity Date of This ADC [1]
Efficacy Data Half Maximal Inhibitory Concentration (IC50) 69.00 nM Positive ITGA10 expression (ITGA10+++/++)
Method Description
Viability analysis of U3046 mg GBM cells after treatment with increasing concentration of anti-alpha10-SAP or anti-ctrl-SAP for 96 h.
In Vitro Model Glioblastoma U3046MG cells CVCL_IR78
References
Ref 1 Integrin 10, a Novel Therapeutic Target in Glioblastoma, Regulates Cell Migration, Proliferation, and Survival. Cancers (Basel). 2019 Apr 25;11(4):587. doi: 10.3390/cancers11040587.

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