Target Information
General Information of This Target
| Target ID | PATR0RIOXT |
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|---|---|---|---|---|---|---|
| Target Name | Human deoxyribonucleic acid (hDNA) |
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| Function |
Deoxyribonucleic acid (DNA) is a polymer composed of two polynucleotide chains that coil around each other to form a double helix. The polymer carries genetic instructions for the development, functioning, growth and reproduction of all known organisms and many viruses. DNA and ribonucleic acid (RNA) are nucleic acids.
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Full List of The ADC Related to This Target
Approved in 2021
| ADC Info | ADC Name | Antibody | Antigen | Payload | Linker | Ref |
|---|---|---|---|---|---|---|
Loncastuximab tesirine |
Loncastuximab |
CD19 |
SG3199 (SC-DR002) |
Mal-PEG8-Val-Ala-PABC |
||
Inotuzumab ozogamicin |
Inotuzumab |
CD22 |
N-acetyl-gamma-calicheamicin |
AcButDMH |
[1] | |
Gemtuzumab ozogamicin |
Gemtuzumab |
CD33 |
N-acetyl-gamma-calicheamicin |
AcButDMH |
[2] |
New Drug Application (discontinued)
| ADC Info | ADC Name | Antibody | Antigen | Payload | Linker | Ref |
|---|---|---|---|---|---|---|
Trastuzumab duocarmazine |
Trastuzumab |
HER2 |
Seco-DUBA |
Mal-PEG2-Val-Cit-PABA-Cyclization Spacer |
Phase 3 (discontinued)
| ADC Info | ADC Name | Antibody | Antigen | Payload | Linker | Ref |
|---|---|---|---|---|---|---|
Rovalpituzumab tesirine |
Rovalpituzumab |
DLL3 |
SG3199 (SC-DR002) |
Mal-PEG8-Val-Ala-PABC |
||
Vadastuximab talirine |
Vadastuximab |
CD33 |
SGD-1882 |
Mc-Val-Ala |
Phase 2 (discontinued)
| ADC Info | ADC Name | Antibody | Antigen | Payload | Linker | Ref |
|---|---|---|---|---|---|---|
Camidanlumab tesirine |
Camidanlumab |
CD25 |
SG3199 (SC-DR002) |
Mal-PEG8-Val-Ala-PABC |
||
Vobramitamab duocarmazine |
Vobramitamab |
B7-H3 |
seco-DUBA |
Mal-PEG2-Val-Cit-PABA-Cyclization Spacer |
Phase 2 (discontinued)
| ADC Info | ADC Name | Antibody | Antigen | Payload | Linker | Ref |
|---|---|---|---|---|---|---|
CMB-401 |
HCTM01 |
Muc1 |
N-acetyl-gamma-calicheamicin |
Amide-based linker |
Apprpved in 2026
| ADC Info | ADC Name | Antibody | Antigen | Payload | Linker | Ref |
|---|---|---|---|---|---|---|
Pivekimab sunirine |
Pivekimab |
CD123 |
DGN549 |
Mal-adipamide-Ala-Ala |
||
Epratuzumab-cys-tesirine |
Epratuzumab |
CD22 |
SG3199 (SC-DR002) |
Mal-PEG8-Val-Ala-PABC |
Phase 1
| ADC Info | ADC Name | Antibody | Antigen | Payload | Linker | Ref |
|---|---|---|---|---|---|---|
BYON3521 |
SYD2884 |
c-Met |
Seco-DUBA |
Mal-PEG2-Val-Cit-PABA-Cyclization Spacer |
||
DS-9606a |
Anti-CLDN6 antibody |
CLDN6 |
PBD dimer |
A cleavable linker |
||
LCB73 |
Anti-CD19 antibody |
CD19 |
PBD dimer |
β-glucuronide trigger linker |
||
ABL202 |
Anti-ROR1 IgG1 mAb |
ROR1 |
PBD dimer |
β-glucuronide trigger linker |
||
Mipasetamab uzoptirine |
Mipasetamab |
Axl |
SG3199 (SC-DR002) |
BCN-HydraSpace-Val-Ala-PABC |
||
MT-8633 |
HD12 |
c-Met |
SG3199 (SC-DR002) |
Mal-PEG8-Val-Ala-PABC |
||
BYON-4413 |
Anti-CD123 IgG1 mAb |
CD123 |
Seco-DUBA |
Mal-PEG2-Val-Cit-PABA-Cyclization Spacer |
||
ADCT-701 |
HuBa-1-3D |
DLK1 |
SG3199 (SC-DR002) |
BCN-HydraSpace-Val-Ala-PABC |
||
Olintatug tesirine |
Olintatug |
KAAG1 |
SG3199 (SC-DR002) |
Mal-PEG8-Val-Ala-PABC |
Phase 1 (discontinued)
| ADC Info | ADC Name | Antibody | Antigen | Payload | Linker | Ref |
|---|---|---|---|---|---|---|
MEDI2228 |
BCMA-Ab1 |
BCMA |
SG3199 (SC-DR002) |
Mal-PEG8-Val-Ala-PABC |
||
MEDI3726 |
J591 |
PSMA |
SG3199 (SC-DR002) |
Mal-PEG8-Val-Ala-PABC |
||
Rolinsatamab talirine |
Rolinsatamab |
PRLR |
SGD-1882 |
Mc-Val-Ala |
||
SC-002 |
Rovalpituzumab |
DLL3 |
SG3199 (SC-DR002) |
Val-Ala dipeptide linker |
||
SC-006 |
Anti-RNF43 antibody |
RNF43 |
SG3312 (SC-DR003) |
Mc-Val-Ala |
||
ABBV-011 |
SC17 |
SEZ6 |
N-acetyl-gamma-calicheamicin |
Mc-PEG8-acid-labile linker |
||
Serclutamab talirine |
Serclutamab |
EGFR |
SGD-1882 |
Mc-Val-Ala |
||
SYD1875 |
SYD1594 |
5T4 |
Seco-DUBA |
Mal-PEG2-Val-Cit-PABA-Cyclization Spacer |
||
TAK-164 |
5F9 |
GC-C |
DGN549 |
Mal-adipamide-Ala-Ala |
||
Tamrintamab pamozirine |
Tamrintamab |
DPEP3 |
SG3199 (SC-DR002) |
Mc-Val-Ala-PABC |
||
ADCT-502 |
Trastuzumab variant |
HER2 |
SG3199 (SC-DR002) |
Mal-PEG8-Val-Ala-PABC |
||
CMD-193 |
G193 |
Lewis Y |
N-acetyl-gamma-calicheamicin |
AcButDMH |
||
PF-06647263 |
HuE22 |
EFNA4 |
N-acetyl-gamma-calicheamicin |
AcButDMH |
||
RG6148 |
MHES0488A |
HER2 |
PBD dimer |
Cleavable disulfide linker |
||
SC-007 |
undisclosed |
Undisclosed |
PBD dimer |
Undisclosed |
||
SGN-CD123A |
H7G3ec |
CD123 |
SGD-1882 |
Mc-Val-Ala |
||
SGN-CD19B |
HBU12ec |
CD19 |
SGD-1882 |
Mc-Val-Ala |
||
SGN-CD352A |
H20F3ec |
SLAMF6 |
PBD dimer |
Val-Ala dipeptide linker |
||
SGN-CD70A |
H1F6ec |
CD70 |
PBD dimer |
dipeptide linker |
||
SC-004 |
An antibody targeting CLDN6/9 |
CLDN6; CLDN9 |
SGD-1882 |
Val-Cit linker |
||
BMS-936561 |
MDX-1115 |
CD70 |
Seco-MED-A |
Mal-Val-Cit |
||
IMGN779 |
Z4681A |
CD33 |
DGN462 |
Sulfo-SPDB |
||
RG6109 |
MCLL0517A |
CLL-1 |
PBD dimer |
Cleavable disulfide linker |
||
SC-005 |
undisclosed |
Undisclosed |
PBD dimer |
Undisclosed |
[3] | |
MEDI7247 |
Idactamab |
ASCT2 |
SG3199 (SC-DR002) |
Mal-PEG8-Val-Ala-PABC |
Investigative
| ADC Info | ADC Name | Antibody | Antigen | Payload | Linker | Ref |
|---|---|---|---|---|---|---|
111In-1849 |
Anti-TF mAb 1849 |
Tissue factor (F3) |
Indium-111 |
Undisclosed |
[4] | |
111In-DOTA-5D3 |
Anti-PSMA mAb 5D3 |
Glutamate carboxypeptidase 2 (FOLH1) |
Indium-111 |
Tetraxetan |
[5] | |
T-PBA |
Trastuzumab |
Receptor tyrosine-protein kinase erbB-2 (ERBB2) |
PBD-based payload 37b3 |
Mc-Val-Ala |
[6] | |
WO2021044208A1 ADC A2F2 M1-6 |
Anti-ROR1 mAb A2F2 M1 |
Inactive tyrosine-protein kinase transmembrane receptor ROR1 (ROR1) |
SG2000 |
WO2021044208A1_ADC A2F2 M1-6 linker |
[7] | |
WO2021044208A1 ADC A2F2 M1-6 |
Anti-ROR1 mAb A2F2 M1 |
Inactive tyrosine-protein kinase transmembrane receptor ROR1 (ROR1) |
SG2000 |
WO2021044208A1_ADC A2F2 M1-7 linker |
[7] | |
Trastuzumab-Flexmab-SG3710 |
Trastuzumab-Flexmab |
Receptor tyrosine-protein kinase erbB-2 (ERBB2) |
SG3199 |
Mal-PEG8-Val-Ala-PABC |
[8] | |
Trastuzumab-C239I-SG3249 |
Trastuzumab |
Receptor tyrosine-protein kinase erbB-2 (ERBB2) |
SG3199 |
Mal-PEG8-Val-Ala-PABC |
[8] | |
Trastuzumab-C239I-SG3600 |
Engineered trastuzumab |
Receptor tyrosine-protein kinase erbB-2 (ERBB2) |
N10-beta-glucuronide SG3200 |
Mal-PEG8-Val-Ala-PABC |
[9] | |
Trastuzumab-C239I-SG3400 |
Engineered trastuzumab |
Receptor tyrosine-protein kinase erbB-2 (ERBB2) |
SG3200 |
Mal-PEG8-Val-Ala-PABC |
[9] | |
Fv-LDP-D3-AE |
Fv-LDP-D3 |
Epidermal growth factor receptor (EGFR) |
Lidamycin |
Undisclosed |
[10] | |
Cetuximab- (FGX16-11) |
Cetuximab |
Epidermal growth factor receptor (EGFR) |
FGX8-46 |
Mc-Val-Ala-PABC |
[11] | |
D3-GPC2-PBD |
Fully human D3-GPC2-IgG1 |
Glypican-2 (GPC2) |
PBD dimer |
Undisclosed |
[12] | |
Trastuzumab-SG3227 |
Trastuzumab |
Receptor tyrosine-protein kinase erbB-2 (ERBB2) |
SG2219 |
Acetamide-PEG4-Val-Ala-PABA |
[13] | |
Engineered HER-SG3227 |
Engineered trastuzumab |
Receptor tyrosine-protein kinase erbB-2 (ERBB2) |
SG2219 |
Acetamide-PEG4-Val-Ala-PABA |
[13] | |
HER-SG3249 |
Trastuzumab |
Receptor tyrosine-protein kinase erbB-2 (ERBB2) |
SG3199 |
Mal-PEG8-Val-Ala-PABC |
[14] | |
Site-specific HER-SG3249 |
Trastuzumab |
Receptor tyrosine-protein kinase erbB-2 (ERBB2) |
SG3199 |
Mal-PEG8-Val-Ala-PABC |
[14] | |
Trastuzumab-SG3600 high DAR |
Trastuzumab |
Receptor tyrosine-protein kinase erbB-2 (ERBB2) |
N10-beta-glucuronide SG3200 |
Mal-PEG8-Val-Ala-PABC |
[9] | |
40H3-Tesirine |
Anti-EGFR mAb 40H3 |
Epidermal growth factor receptor (EGFR) |
SG3199 |
Mal-PEG8-Val-Ala-PABC |
[15] | |
Anti-CD22- (LC:K149C)-SN36248 |
Pinatuzumab |
B-cell receptor CD22 (CD22) |
seco-CBI-dimer |
Mal-PEG2 |
[16] | |
AT-03 |
Anti-CLDN6 antibody |
CLDN6 |
TCS132 (AxcynDOT) |
A cleavable linker |
[17] | |
M276-SL-PBD |
Anti-CD276 mAb m276-SL |
CD276 antigen (CD276) |
PBD dimer |
Mc-Val-Ala |
[18] | |
KTN0182A |
Undisclosed |
Mast/stem cell growth factor receptor Kit (KIT) |
PBD dimer |
Undisclosed |
[19] | |
EV20/NMS-P945 |
EV20 |
Receptor tyrosine-protein kinase erbB-3 (ERBB3) |
NMS-P528 |
Cathepsin-cleavable peptidic linker with self-immolating spacer |
[20] | |
Trastuzumab-BCN-HydraSpace-Val-Cit-PABC-Gly-Calicheamicin |
Trastuzumab |
Receptor tyrosine-protein kinase erbB-2 (ERBB2) |
Gly-calicheamicin |
BCN-HydraSpace-Val-Cit-PABC |
[21] | |
Trastuzumab SG-3259 |
Trastuzumab |
Receptor tyrosine-protein kinase erbB-2 (ERBB2) |
SG3312 |
Mc-Val-Ala |
[22] | |
Trastuzumab-SG3400 high DAR |
Trastuzumab |
Receptor tyrosine-protein kinase erbB-2 (ERBB2) |
SG3200 |
Mal-PEG8-Val-Ala-PABC |
[9] | |
Promiximab-DUBA |
Promiximab |
Neural cell adhesion molecule 1 (NCAM1) |
seco-DUBA |
Mal-Val-Cit-PABA-Cyclization spacer |
[23] | |
MUC16-Mc-Val-Cit-PABC-CBI dimer |
Thio hu Anti-MUC16 |
Mucin-16 (MUC16) |
seco-CBI-dimer |
Mc-Val-Cit-PABC |
[24] | |
Anti-CD22-SN36248 |
Anti-CD22 10F4 Thiomab (LC:K149C) |
B-cell receptor CD22 (CD22) |
seco-CBI-dimer |
Mal-PEG2 |
[16] | |
T1LD7 |
Anti-IL1RL1 mAb |
Interleukin-1 receptor-like 1 (IL1RL1) |
N-acetyl-gamma-calicheamicin |
Mal-Val-Cit-PABC-EDA |
[25] | |
Recombinant humanized anti-EGFR mAb-DUO-5 conjugate |
Undisclosed |
Epidermal growth factor receptor (EGFR) |
Duostatin 5 |
Undisclosed |
[26] | |
HuB4-DGN462 |
Undisclosed |
B-lymphocyte antigen CD19 (CD19) |
DGN462 |
Sulfo-SPDB |
[27] | |
B4-SPP-DC44 |
Anti-CD19 mAb B4 |
B-lymphocyte antigen CD19 (CD19) |
DC44 |
N-succinimidyl 4-(2-pyridyldithio) pentanoate (SPP) |
[28] | |
HuC242-SPP-DC4 |
Cantuzumab |
Syndecan-1 (SDC1) |
Phosphate prodrugs 40 (DC4) |
N-succinimidyl 4-(2-pyridyldithio) pentanoate (SPP) |
[28] | |
HuC242-SPDB-DC4 |
Cantuzumab |
Syndecan-1 (SDC1) |
Phosphate prodrugs 40 (DC4) |
N-succinimidyl 4-(2-pyridyldithio) butanoate (SPDB) |
[28] | |
HuC242-SMCC-DC4 |
Cantuzumab |
Syndecan-1 (SDC1) |
Phosphate prodrugs 40 (DC4) |
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC) |
[28] | |
B4-SMCC-DC4 |
Anti-CD19 mAb B4 |
B-lymphocyte antigen CD19 (CD19) |
Phosphate prodrugs 40 (DC4) |
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC) |
[28] | |
B4-SPP-DC4 |
Anti-CD19 mAb B4 |
B-lymphocyte antigen CD19 (CD19) |
Phosphate prodrugs 40 (DC4) |
N-succinimidyl 4-(2-pyridyldithio) pentanoate (SPP) |
[28] | |
B4-SPP-DC1 |
Anti-CD19 mAb B4 |
B-lymphocyte antigen CD19 (CD19) |
DC1 |
N-succinimidyl 4-(2-pyridyldithio) pentanoate (SPP) |
[28] | |
Anti-B4 monoclonal antibody-DC1 conjugate |
Undisclosed |
B-lymphocyte antigen CD19 (CD19) |
DC1 |
Undisclosed |
[29] | |
REGN-3124-PBD |
REGN3124 |
Epidermal growth factor receptor variant III (EGFRvIII) |
SG3199 |
Mal-PEG8-Val-Ala-PABC |
[30] | |
CD25-ADC |
Anti-CD25 mAb PC61 |
Interferon-stimulated gene 20 kDa protein (ISG20) |
SG3199 |
Mal-PEG8-Val-Ala-PABC |
[31] | |
HLL2-PBD |
Epratuzumab |
B-cell receptor CD22 (CD22) |
SG3199 |
Mal-PEG8-Val-Ala-PABC |
[32] | |
GFRA1 targeted antibody-drug conjugate |
Anti-GFRA1 mAb |
GDNF family receptor alpha-1 (GFRA1) |
SG3199 |
Mal-PEG8-Val-Ala-PABC |
[33] | |
MEDI-0641 |
5T4_0108 |
Trophoblast glycoprotein (TPBG) |
5T4-PBD |
Mal-PEG8-Val-Ala-PABC |
[34] | |
Anti-CD30-LDM |
Recombinant human CD30Fc fusion protein |
Tumor necrosis factor receptor superfamily member 8 (TNFRSF8) |
Lidamycin |
Uncleavable linker |
[35] | |
NV105 |
Undisclosed |
CD276 antigen (CD276) |
Temozolomide |
Undisclosed |
[36] | |
CD33-CPI dimer ADC |
Anti-CD33 Anti-ody 11A1 |
Myeloid cell surface antigen CD33 (CD33) |
Bicyclopentyl-seco-CBI-dimer |
AcLys-Val-Cit-PABC-DMAE |
[37] | |
HuN901-CC-1065 |
Lorvotuzumab |
Neural cell adhesion molecule 1 (NCAM1) |
Rachelmycin |
Cleavable disulfide |
[38] | |
Monoclonal antibody A5B7-cisplatin conjugate |
Anti-CEACAM5 mAb A5B7 |
Pregnancy-specific beta-1-glycoprotein 2 (PSG2) |
Cisplatin |
Undisclosed |
[39] | |
PYX-203 |
Undisclosed |
Interleukin-3 receptor subunit alpha (IL3RA) |
Cyclopropylpyrroloindole (CPI) DNA-damaging payload |
Lysosomal cleavable linker |
[40] | |
CD123-CPI ADC (Pfizer) |
Undisclosed |
Interleukin-3 receptor subunit alpha (IL3RA) |
Cyclopropylpyrroloindoline (CPI) payload |
Undisclosed |
[41] | |
CLL1-ADC |
Fully humanized Anti-CLL1 mAb |
C-type lectin domain family 12 member A (CLEC12A) |
D211 |
Mal-PEG8-Val-Cit-PABC |
[42] | |
CyEt-Pan-Duo |
Panitumumab |
Epidermal growth factor receptor (EGFR) |
DEAEA duocarmycin |
Mal-PEG4-Triazol-Cyanine cage |
[43] | |
Anti-PDGFRB cotinine scFv-C-scFv-duocarmycin |
Bispecific Anti-PDGFRB + cotinine scFv-C-scFv fusion protein |
Platelet-derived growth factor receptor beta (PDGFRB) |
DEAEA duocarmycin |
PEG3-Val-Cit-PABC |
[44] | |
RC58-ADC-1 |
RC58 |
B-lymphocyte antigen CD19 (CD19) |
Dumycin-7 |
Bis-bromine linker-PEG4-Asn-Ala-ethylenediamine |
[45] | |
D2B-DCM |
Anti-PSMA mAb D2B |
Glutamate carboxypeptidase 2 (FOLH1) |
Duocarmycin A |
Mc-Val-Cit-PABC |
[46] | |
B2M-duocarmycin ADC |
LS-B2200 |
Beta-2-microglobulin (B2M) |
Duocarmycin A |
Bis-Tolylsulfonyl-Propanoyl-Benzamide-Glu-NH-PEG(24u)-OMe-Val-Cit-PAB |
[47] | |
Anti-PDGFRB C-scFv Duocarmycin |
Anti-mouse PDGFRB Anti-ody |
Platelet-derived growth factor receptor beta (PDGFRB) |
Duocarmycin A |
Undisclosed |
[44] | |
ENDOS/ADC |
Anti-CD248 mAb hMP-E-8.3 |
Endosialin (CD248) |
Duocarmycin derivative |
Val-Cit |
[48] | |
Trastuzumab-BCN-HydraSpace-Val-Cit-PABC-Duocarmycin |
Trastuzumab |
Receptor tyrosine-protein kinase erbB-2 (ERBB2) |
Duocarmycin Sa |
BCN-HydraSpace-Val-Cit-PABC |
[21] | |
HYP7-DC |
Humanized GPC3-specific Anti-ody YP7 |
Glypican-3 (GPC3) |
Duocarmycin Sa |
Mal-PEG4-Val-Cit-PABC-DMAE |
[49] | |
PCM5B14-DCM |
H5B14 |
Macrophage-stimulating protein receptor (MST1R) |
Duocarmycin Sa |
Mc-PEG4-Val-Cit-PABC-DMAE |
[50] | |
Cotinine-duocarmycin |
ERC6 bispecific Anti-ody (fuse Anti-cotinine scFv to cetuximab CH3 domain) |
Epidermal growth factor receptor (EGFR) |
Duocarmycin Sa |
Mc-Val-Cit-PABC-DMAE |
[44] | |
GPR56-ADC |
Anti-GPR56 Anti-ody 10C7 |
Adhesion G-protein coupled receptor G1 (ADGRG1) |
Duocarmycin Sa |
Mal-Val-Cit-PABC-DMEA-PEG2 |
[51] | |
ZV-0508 |
ZV05 |
Trophoblast glycoprotein (TPBG) |
Duostatin 5 |
C-Lock-ANN tri-peptide |
[52] | |
Adalimumab fosimdesonide |
Adalimumab |
Tumor necrosis factor (TNF) |
SGD-1882 |
Undisclosed |
[53] | |
CIRCR201-dPBD |
Anti-MET mAb cIRCR201 |
Hepatocyte growth factor receptor (MET) |
Glucuronide-dPBD |
Iso-PEG5-beta-glucuronide |
[54] | |
LA22-MMC |
Anti-EGFR mAb LA22 |
Epidermal growth factor receptor (EGFR) |
Mitomycin C |
N-succinimidyl 3-(2-pyridyldithio) propionate (SPDP) |
[55] | |
Trastuzumab-BCN-HydraSpace-Val-Cit-PABC-Calicheamicin |
Trastuzumab |
Receptor tyrosine-protein kinase erbB-2 (ERBB2) |
N-acetyl-gamma-calicheamicin |
BCN-HydraSpace-Val-Cit-PABC |
[21] | |
T1LD6 |
Anti-IL1RL1 mAb |
Interleukin-1 receptor-like 1 (IL1RL1) |
N-methyl-uncialamycin |
Mal-Val-Cit-gucuronide-PEG8-PABC |
[25] | |
T1LD5 |
Anti-IL1RL1 mAb |
Interleukin-1 receptor-like 1 (IL1RL1) |
N-methyl-uncialamycin |
Mal-Val-Cit-glucuronide-PABC |
[25] | |
T1LD4 |
Anti-IL1RL1 mAb |
Interleukin-1 receptor-like 1 (IL1RL1) |
N-methyl-uncialamycin |
Mal-glucuronidase cleavable linker |
[25] | |
T1LD3 |
Anti-IL1RL1 mAb |
Interleukin-1 receptor-like 1 (IL1RL1) |
N-methyl-uncialamycin |
Mal-PEG8 |
[25] | |
T1LD2 |
Anti-IL1RL1 mAb |
Interleukin-1 receptor-like 1 (IL1RL1) |
N-methyl-uncialamycin |
Mal-acetic acid |
[25] | |
T1LD1 |
Anti-IL1RL1 mAb |
Interleukin-1 receptor-like 1 (IL1RL1) |
N-methyl-uncialamycin |
Mal-Val-Cit-PABC |
[25] | |
T2LD6 |
Anti-CD46 mAb |
Membrane cofactor protein (CD46) |
N-methyl-uncialamycin |
Mal-Val-Cit-gucuronide-PEG8-PABC |
[25] | |
T2LD5 |
Anti-CD46 mAb |
Membrane cofactor protein (CD46) |
N-methyl-uncialamycin |
Mal-Val-Cit-glucuronide-PABC |
[25] | |
T2LD4 |
Anti-CD46 mAb |
Membrane cofactor protein (CD46) |
N-methyl-uncialamycin |
Mal-glucuronidase cleavable linker |
[25] | |
T2LD3 |
Anti-CD46 mAb |
Membrane cofactor protein (CD46) |
N-methyl-uncialamycin |
Mal-PEG8 |
[25] | |
T2LD2 |
Anti-CD46 mAb |
Membrane cofactor protein (CD46) |
N-methyl-uncialamycin |
Mal-acetic acid |
[25] | |
T2LD1 |
Anti-CD46 mAb |
Membrane cofactor protein (CD46) |
N-methyl-uncialamycin |
Mal-Val-Cit-PABC |
[25] | |
ACD22-LC-K149C-10 |
Anti-CD22-LC-K149C |
B-cell receptor CD22 (CD22) |
PA-seco-CBI-dimer |
Mc-cBu-Cit |
[56] | |
Anti-ICOS-PBD |
Murine Anti-ICOS Anti-ody |
Inducible T-cell costimulator (ICOS) |
PBD dimer |
Undisclosed |
[57] | |
Masked ADC (Adagene/ADC Therapeutics) |
Undisclosed |
Undisclosed |
PBD dimer |
Undisclosed |
[58] | |
Trastuzumab-BCN-HydraSpace-Val-Ala-PABC-PBD dimer |
Trastuzumab |
Receptor tyrosine-protein kinase erbB-2 (ERBB2) |
PBD dimer 2 |
BCN-HydraSpace-Val-Ala-PABC |
[21] | |
Trastuzumab-DNA mimic 4 |
Trastuzumab |
Receptor tyrosine-protein kinase erbB-2 (ERBB2) |
Q Pho-DNA mimics |
Diphenyltio-Mal-Cap |
[59] | |
ADCT-211 |
Anti-IL13RA2 mAb huCl47 |
Interleukin-13 receptor subunit alpha-2 (IL13RA2) |
SG2000 |
Vali-Ala cleavable linker |
[60] | |
ADCT-212 |
Undisclosed |
Prostate-specific antigen (KLK3) |
SG2000 |
Vali-Ala cleavable linker |
[61] | |
Anti-IL13RA2 PBD ADC |
Anti-IL13RA2 mAb 2E10 |
Interleukin-13 receptor subunit alpha-2 (IL13RA2) |
SGD-1882 |
Mc-Val-Ala |
[62] | |
Anti-FucGM1-45 ADC |
Anti-FucGM1 mAb |
Fucosylated monosialotetrahexosylganglioside (FucGM1) |
Tetrahydroisoquinoline-based PBD dimer 17 |
Mc-Val-Cit-PABC |
[63] | |
Anti-FucGM1-46 ADC |
Anti-FucGM1 mAb |
Fucosylated monosialotetrahexosylganglioside (FucGM1) |
Tetrahydroisoquinoline-based PBD dimer 17 |
PEG2-Val-Cit-PABC |
[63] | |
Anti-FucGM1-47 ADC |
Anti-FucGM1 mAb |
Fucosylated monosialotetrahexosylganglioside (FucGM1) |
Tetrahydroisoquinoline-based PBD dimer 17 |
PEG4-Val-Cit-PABC |
[63] | |
Anti-FucGM1-48 ADC |
Anti-FucGM1 mAb |
Fucosylated monosialotetrahexosylganglioside (FucGM1) |
Tetrahydroisoquinoline-based PBD dimer 17 |
PEG8-Val-Cit-PABC |
[63] | |
Anti-CD70-45 ADC |
Anti-CD70 mAb |
CD70 antigen (CD70) |
Tetrahydroisoquinoline-based PBD dimer 17 |
Mc-Val-Cit-PABC |
[63] | |
Anti-MSLN-45 ADC |
Anti-MSLN mAb |
Mesothelin (MSLN) |
Tetrahydroisoquinoline-based PBD dimer 17 |
Mc-Val-Cit-PABC |
[63] | |
Anti-MSLN-46 ADC |
Anti-MSLN mAb |
Mesothelin (MSLN) |
Tetrahydroisoquinoline-based PBD dimer 17 |
PEG2-Val-Cit-PABC |
[63] | |
Anti-MSLN-47 ADC |
Anti-MSLN mAb |
Mesothelin (MSLN) |
Tetrahydroisoquinoline-based PBD dimer 17 |
PEG4-Val-Cit-PABC |
[63] | |
Anti-MSLN-48 ADC |
Anti-MSLN mAb |
Mesothelin (MSLN) |
Tetrahydroisoquinoline-based PBD dimer 17 |
PEG8-Val-Cit-PABC |
[63] | |
Anti-MSLN-44 ADC |
Anti-MSLN mAb |
Mesothelin (MSLN) |
Tetrahydroisoquinoline-based PBD dimer 14 |
Mal-PEG8-Val-Cit-PABC |
[63] | |
IKS-01 |
Isumab01 |
Folate receptor alpha (FOLR1) |
FGX2-62 |
Undisclosed |
[64] | |
IPH43 |
Glycosylated Anti-MICA Anti-ody |
MHC class I polypeptide-related sequence A (MICA) |
PBD dimer |
Undisclosed |
[65] | |
SC16.3-DL2 |
SC16.3 |
Delta-like protein 3 (DLL3) |
SG3312 |
Mc-Val-Ala |
[66] | |
SC16.4-DL2 |
SC16.4 |
Delta-like protein 3 (DLL3) |
SG3312 |
Mc-Val-Ala |
[66] | |
SC16.5-DL2 |
SC16.5 |
Delta-like protein 3 (DLL3) |
SG3312 |
Mc-Val-Ala |
[66] | |
SC16.7-DL2 |
SC16.7 |
Delta-like protein 3 (DLL3) |
SG3312 |
Mc-Val-Ala |
[66] | |
SC16.8-DL2 |
SC16.8 |
Delta-like protein 3 (DLL3) |
SG3312 |
Mc-Val-Ala |
[66] | |
SC16.10-DL2 |
SC16.10 |
Delta-like protein 3 (DLL3) |
SG3312 |
Mc-Val-Ala |
[66] | |
SC16.11-DL2 |
SC16.11 |
Delta-like protein 3 (DLL3) |
SG3312 |
Mc-Val-Ala |
[66] | |
SC16.13-DL2 |
SC16.13 |
Delta-like protein 3 (DLL3) |
SG3312 |
Mc-Val-Ala |
[66] | |
SC16.15-DL2 |
SC16.15 |
Delta-like protein 3 (DLL3) |
SG3312 |
Mc-Val-Ala |
[66] | |
SC16.18-DL2 |
SC16.18 |
Delta-like protein 3 (DLL3) |
SG3312 |
Mc-Val-Ala |
[66] | |
SC16.19-DL2 |
SC16.19 |
Delta-like protein 3 (DLL3) |
SG3312 |
Mc-Val-Ala |
[66] | |
SC16.20-DL2 |
SC16.20 |
Delta-like protein 3 (DLL3) |
SG3312 |
Mc-Val-Ala |
[66] | |
SC16.21-DL2 |
SC16.21 |
Delta-like protein 3 (DLL3) |
SG3312 |
Mc-Val-Ala |
[66] | |
SC16.22-DL2 |
SC16.22 |
Delta-like protein 3 (DLL3) |
SG3312 |
Mc-Val-Ala |
[66] | |
SC16.23-DL2 |
SC16.23 |
Delta-like protein 3 (DLL3) |
SG3312 |
Mc-Val-Ala |
[66] | |
SC16.25-DL2 |
SC16.25 |
Delta-like protein 3 (DLL3) |
SG3312 |
Mc-Val-Ala |
[66] | |
SC16.26-DL2 |
SC16.26 |
Delta-like protein 3 (DLL3) |
SG3312 |
Mc-Val-Ala |
[66] | |
SC16.29-DL2 |
SC16.29 |
Delta-like protein 3 (DLL3) |
SG3312 |
Mc-Val-Ala |
[66] | |
SC16.30-DL2 |
SC16.30 |
Delta-like protein 3 (DLL3) |
SG3312 |
Mc-Val-Ala |
[66] | |
SC16.31-DL2 |
SC16.31 |
Delta-like protein 3 (DLL3) |
SG3312 |
Mc-Val-Ala |
[66] | |
SC16.34-DL2 |
SC16.34 |
Delta-like protein 3 (DLL3) |
SG3312 |
Mc-Val-Ala |
[66] | |
SC16.35-DL2 |
SC16.35 |
Delta-like protein 3 (DLL3) |
SG3312 |
Mc-Val-Ala |
[66] | |
SC16.36-DL2 |
SC16.36 |
Delta-like protein 3 (DLL3) |
SG3312 |
Mc-Val-Ala |
[66] | |
SC16.38-DL2 |
SC16.38 |
Delta-like protein 3 (DLL3) |
SG3312 |
Mc-Val-Ala |
[66] | |
SC16.41-DL2 |
SC16.41 |
Delta-like protein 3 (DLL3) |
SG3312 |
Mc-Val-Ala |
[66] | |
SC16.42-DL2 |
SC16.42 |
Delta-like protein 3 (DLL3) |
SG3312 |
Mc-Val-Ala |
[66] | |
SC16.45-DL2 |
SC16.45 |
Delta-like protein 3 (DLL3) |
SG3312 |
Mc-Val-Ala |
[66] | |
SC16.47-DL2 |
SC16.47 |
Delta-like protein 3 (DLL3) |
SG3312 |
Mc-Val-Ala |
[66] | |
SC16.49-DL2 |
SC16.49 |
Delta-like protein 3 (DLL3) |
SG3312 |
Mc-Val-Ala |
[66] | |
SC16.50-DL2 |
SC16.50 |
Delta-like protein 3 (DLL3) |
SG3312 |
Mc-Val-Ala |
[66] | |
SC16.52-DL2 |
SC16.52 |
Delta-like protein 3 (DLL3) |
SG3312 |
Mc-Val-Ala |
[66] | |
SC16.55-DL2 |
SC16.55 |
Delta-like protein 3 (DLL3) |
SG3312 |
Mc-Val-Ala |
[66] | |
SC16.56-DL2 |
SC16.56 |
Delta-like protein 3 (DLL3) |
SG3312 |
Mc-Val-Ala |
[66] | |
SC16.57-DL2 |
SC16.57 |
Delta-like protein 3 (DLL3) |
SG3312 |
Mc-Val-Ala |
[66] | |
SC16.58-DL2 |
SC16.58 |
Delta-like protein 3 (DLL3) |
SG3312 |
Mc-Val-Ala |
[66] | |
SC16.61-DL2 |
SC16.61 |
Delta-like protein 3 (DLL3) |
SG3312 |
Mc-Val-Ala |
[66] | |
SC16.62-DL2 |
SC16.62 |
Delta-like protein 3 (DLL3) |
SG3312 |
Mc-Val-Ala |
[66] | |
SC16.63-DL2 |
SC16.63 |
Delta-like protein 3 (DLL3) |
SG3312 |
Mc-Val-Ala |
[66] | |
SC16.65-DL2 |
SC16.65 |
Delta-like protein 3 (DLL3) |
SG3312 |
Mc-Val-Ala |
[66] | |
SC16.67-DL2 |
SC16.67 |
Delta-like protein 3 (DLL3) |
SG3312 |
Mc-Val-Ala |
[66] | |
SC16.68-DL2 |
SC16.68 |
Delta-like protein 3 (DLL3) |
SG3312 |
Mc-Val-Ala |
[66] | |
SC16.72-DL2 |
SC16.72 |
Delta-like protein 3 (DLL3) |
SG3312 |
Mc-Val-Ala |
[66] | |
SC16.73-DL2 |
SC16.73 |
Delta-like protein 3 (DLL3) |
SG3312 |
Mc-Val-Ala |
[66] | |
SC16.78-DL2 |
SC16.78 |
Delta-like protein 3 (DLL3) |
SG3312 |
Mc-Val-Ala |
[66] | |
SC16.79-DL2 |
SC16.79 |
Delta-like protein 3 (DLL3) |
SG3312 |
Mc-Val-Ala |
[66] | |
SC16.80-DL2 |
SC16.80 |
Delta-like protein 3 (DLL3) |
SG3312 |
Mc-Val-Ala |
[66] | |
SC16.81-DL2 |
SC16.81 |
Delta-like protein 3 (DLL3) |
SG3312 |
Mc-Val-Ala |
[66] | |
SC16.84-DL2 |
SC16.84 |
Delta-like protein 3 (DLL3) |
SG3312 |
Mc-Val-Ala |
[66] | |
SC16.88-DL2 |
SC16.88 |
Delta-like protein 3 (DLL3) |
SG3312 |
Mc-Val-Ala |
[66] | |
SC16.101-DL2 |
SC16.101 |
Delta-like protein 3 (DLL3) |
SG3312 |
Mc-Val-Ala |
[66] | |
SC16.103-DL2 |
SC16.103 |
Delta-like protein 3 (DLL3) |
SG3312 |
Mc-Val-Ala |
[66] | |
SC16.104-DL2 |
SC16.104 |
Delta-like protein 3 (DLL3) |
SG3312 |
Mc-Val-Ala |
[66] | |
SC16.105-DL2 |
SC16.105 |
Delta-like protein 3 (DLL3) |
SG3312 |
Mc-Val-Ala |
[66] | |
SC16.106-DL2 |
SC16.106 |
Delta-like protein 3 (DLL3) |
SG3312 |
Mc-Val-Ala |
[66] | |
SC16.107-DL2 |
SC16.107 |
Delta-like protein 3 (DLL3) |
SG3312 |
Mc-Val-Ala |
[66] | |
SC16.108-DL2 |
SC16.108 |
Delta-like protein 3 (DLL3) |
SG3312 |
Mc-Val-Ala |
[66] | |
SC16.109-DL2 |
SC16.109 |
Delta-like protein 3 (DLL3) |
SG3312 |
Mc-Val-Ala |
[66] | |
SC16.110-DL2 |
SC16.110 |
Delta-like protein 3 (DLL3) |
SG3312 |
Mc-Val-Ala |
[66] | |
SC16.111-DL2 |
SC16.111 |
Delta-like protein 3 (DLL3) |
SG3312 |
Mc-Val-Ala |
[66] | |
SC16.113-DL2 |
SC16.113 |
Delta-like protein 3 (DLL3) |
SG3312 |
Mc-Val-Ala |
[66] | |
SC16.114-DL2 |
SC16.114 |
Delta-like protein 3 (DLL3) |
SG3312 |
Mc-Val-Ala |
[66] | |
SC16.115-DL2 |
SC16.115 |
Delta-like protein 3 (DLL3) |
SG3312 |
Mc-Val-Ala |
[66] | |
SC16.116-DL2 |
SC16.116 |
Delta-like protein 3 (DLL3) |
SG3312 |
Mc-Val-Ala |
[66] | |
SC16.117-DL2 |
SC16.117 |
Delta-like protein 3 (DLL3) |
SG3312 |
Mc-Val-Ala |
[66] | |
SC16.118-DL2 |
SC16.118 |
Delta-like protein 3 (DLL3) |
SG3312 |
Mc-Val-Ala |
[66] | |
SC16.120-DL2 |
SC16.120 |
Delta-like protein 3 (DLL3) |
SG3312 |
Mc-Val-Ala |
[66] | |
SC16.121-DL2 |
SC16.121 |
Delta-like protein 3 (DLL3) |
SG3312 |
Mc-Val-Ala |
[66] | |
SC16.122-DL2 |
SC16.122 |
Delta-like protein 3 (DLL3) |
SG3312 |
Mc-Val-Ala |
[66] | |
SC16.123-DL2 |
SC16.123 |
Delta-like protein 3 (DLL3) |
SG3312 |
Mc-Val-Ala |
[66] | |
SC16.124-DL2 |
SC16.124 |
Delta-like protein 3 (DLL3) |
SG3312 |
Mc-Val-Ala |
[66] | |
SC16.125-DL2 |
SC16.125 |
Delta-like protein 3 (DLL3) |
SG3312 |
Mc-Val-Ala |
[66] | |
SC16.126-DL2 |
SC16.126 |
Delta-like protein 3 (DLL3) |
SG3312 |
Mc-Val-Ala |
[66] | |
SC16.129-DL2 |
SC16.129 |
Delta-like protein 3 (DLL3) |
SG3312 |
Mc-Val-Ala |
[66] | |
SC16.130-DL2 |
SC16.130 |
Delta-like protein 3 (DLL3) |
SG3312 |
Mc-Val-Ala |
[66] | |
SC16.131-DL2 |
SC16.131 |
Delta-like protein 3 (DLL3) |
SG3312 |
Mc-Val-Ala |
[66] | |
SC16.132-DL2 |
SC16.132 |
Delta-like protein 3 (DLL3) |
SG3312 |
Mc-Val-Ala |
[66] | |
SC16.133-DL2 |
SC16.133 |
Delta-like protein 3 (DLL3) |
SG3312 |
Mc-Val-Ala |
[66] | |
SC16.134-DL2 |
SC16.134 |
Delta-like protein 3 (DLL3) |
SG3312 |
Mc-Val-Ala |
[66] | |
SC16.135-DL2 |
SC16.135 |
Delta-like protein 3 (DLL3) |
SG3312 |
Mc-Val-Ala |
[66] | |
SC16.136-DL2 |
SC16.136 |
Delta-like protein 3 (DLL3) |
SG3312 |
Mc-Val-Ala |
[66] | |
SC16.137-DL2 |
SC16.137 |
Delta-like protein 3 (DLL3) |
SG3312 |
Mc-Val-Ala |
[66] | |
SC16.138-DL2 |
SC16.138 |
Delta-like protein 3 (DLL3) |
SG3312 |
Mc-Val-Ala |
[66] | |
SC16.139-DL2 |
SC16.139 |
Delta-like protein 3 (DLL3) |
SG3312 |
Mc-Val-Ala |
[66] | |
SC16.140-DL2 |
SC16.140 |
Delta-like protein 3 (DLL3) |
SG3312 |
Mc-Val-Ala |
[66] | |
SC16.141-DL2 |
SC16.141 |
Delta-like protein 3 (DLL3) |
SG3312 |
Mc-Val-Ala |
[66] | |
SC16.142-DL2 |
SC16.142 |
Delta-like protein 3 (DLL3) |
SG3312 |
Mc-Val-Ala |
[66] | |
SC16.143-DL2 |
SC16.143 |
Delta-like protein 3 (DLL3) |
SG3312 |
Mc-Val-Ala |
[66] | |
SC16.144-DL2 |
SC16.144 |
Delta-like protein 3 (DLL3) |
SG3312 |
Mc-Val-Ala |
[66] | |
SC16.147-DL2 |
SC16.147 |
Delta-like protein 3 (DLL3) |
SG3312 |
Mc-Val-Ala |
[66] | |
SC16.148-DL2 |
SC16.148 |
Delta-like protein 3 (DLL3) |
SG3312 |
Mc-Val-Ala |
[66] | |
SC16.149-DL2 |
SC16.149 |
Delta-like protein 3 (DLL3) |
SG3312 |
Mc-Val-Ala |
[66] | |
SC16.150-DL2 |
SC16.150 |
Delta-like protein 3 (DLL3) |
SG3312 |
Mc-Val-Ala |
[66] | |
SC16.3-DL3 |
SC16.3 |
Delta-like protein 3 (DLL3) |
SG2000 derivative PBD 3 |
Mal-PEG8-Val-Ala |
[66] | |
SC16.4-DL3 |
SC16.4 |
Delta-like protein 3 (DLL3) |
SG2000 derivative PBD 3 |
Mal-PEG8-Val-Ala |
[66] | |
SC16.5-DL3 |
SC16.5 |
Delta-like protein 3 (DLL3) |
SG2000 derivative PBD 3 |
Mal-PEG8-Val-Ala |
[66] | |
SC16.7-DL3 |
SC16.7 |
Delta-like protein 3 (DLL3) |
SG2000 derivative PBD 3 |
Mal-PEG8-Val-Ala |
[66] | |
SC16.8-DL3 |
SC16.8 |
Delta-like protein 3 (DLL3) |
SG2000 derivative PBD 3 |
Mal-PEG8-Val-Ala |
[66] | |
SC16.10-DL3 |
SC16.10 |
Delta-like protein 3 (DLL3) |
SG2000 derivative PBD 3 |
Mal-PEG8-Val-Ala |
[66] | |
SC16.11-DL3 |
SC16.11 |
Delta-like protein 3 (DLL3) |
SG2000 derivative PBD 3 |
Mal-PEG8-Val-Ala |
[66] | |
SC16.13-DL3 |
SC16.13 |
Delta-like protein 3 (DLL3) |
SG2000 derivative PBD 3 |
Mal-PEG8-Val-Ala |
[66] | |
SC16.15-DL3 |
SC16.15 |
Delta-like protein 3 (DLL3) |
SG2000 derivative PBD 3 |
Mal-PEG8-Val-Ala |
[66] | |
SC16.18-DL3 |
SC16.18 |
Delta-like protein 3 (DLL3) |
SG2000 derivative PBD 3 |
Mal-PEG8-Val-Ala |
[66] | |
SC16.19-DL3 |
SC16.19 |
Delta-like protein 3 (DLL3) |
SG2000 derivative PBD 3 |
Mal-PEG8-Val-Ala |
[66] | |
SC16.20-DL3 |
SC16.20 |
Delta-like protein 3 (DLL3) |
SG2000 derivative PBD 3 |
Mal-PEG8-Val-Ala |
[66] | |
SC16.21-DL3 |
SC16.21 |
Delta-like protein 3 (DLL3) |
SG2000 derivative PBD 3 |
Mal-PEG8-Val-Ala |
[66] | |
SC16.22-DL3 |
SC16.22 |
Delta-like protein 3 (DLL3) |
SG2000 derivative PBD 3 |
Mal-PEG8-Val-Ala |
[66] | |
SC16.23-DL3 |
SC16.23 |
Delta-like protein 3 (DLL3) |
SG2000 derivative PBD 3 |
Mal-PEG8-Val-Ala |
[66] | |
SC16.25-DL3 |
SC16.25 |
Delta-like protein 3 (DLL3) |
SG2000 derivative PBD 3 |
Mal-PEG8-Val-Ala |
[66] | |
SC16.26-DL3 |
SC16.26 |
Delta-like protein 3 (DLL3) |
SG2000 derivative PBD 3 |
Mal-PEG8-Val-Ala |
[66] | |
SC16.29-DL3 |
SC16.29 |
Delta-like protein 3 (DLL3) |
SG2000 derivative PBD 3 |
Mal-PEG8-Val-Ala |
[66] | |
SC16.30-DL3 |
SC16.30 |
Delta-like protein 3 (DLL3) |
SG2000 derivative PBD 3 |
Mal-PEG8-Val-Ala |
[66] | |
SC16.31-DL3 |
SC16.31 |
Delta-like protein 3 (DLL3) |
SG2000 derivative PBD 3 |
Mal-PEG8-Val-Ala |
[66] | |
SC16.34-DL3 |
SC16.34 |
Delta-like protein 3 (DLL3) |
SG2000 derivative PBD 3 |
Mal-PEG8-Val-Ala |
[66] | |
SC16.35-DL3 |
SC16.35 |
Delta-like protein 3 (DLL3) |
SG2000 derivative PBD 3 |
Mal-PEG8-Val-Ala |
[66] | |
SC16.36-DL3 |
SC16.36 |
Delta-like protein 3 (DLL3) |
SG2000 derivative PBD 3 |
Mal-PEG8-Val-Ala |
[66] | |
SC16.38-DL3 |
SC16.38 |
Delta-like protein 3 (DLL3) |
SG2000 derivative PBD 3 |
Mal-PEG8-Val-Ala |
[66] | |
SC16.41-DL3 |
SC16.41 |
Delta-like protein 3 (DLL3) |
SG2000 derivative PBD 3 |
Mal-PEG8-Val-Ala |
[66] | |
SC16.42-DL3 |
SC16.42 |
Delta-like protein 3 (DLL3) |
SG2000 derivative PBD 3 |
Mal-PEG8-Val-Ala |
[66] | |
SC16.45-DL3 |
SC16.45 |
Delta-like protein 3 (DLL3) |
SG2000 derivative PBD 3 |
Mal-PEG8-Val-Ala |
[66] | |
SC16.47-DL3 |
SC16.47 |
Delta-like protein 3 (DLL3) |
SG2000 derivative PBD 3 |
Mal-PEG8-Val-Ala |
[66] | |
SC16.49-DL3 |
SC16.49 |
Delta-like protein 3 (DLL3) |
SG2000 derivative PBD 3 |
Mal-PEG8-Val-Ala |
[66] | |
SC16.50-DL3 |
SC16.50 |
Delta-like protein 3 (DLL3) |
SG2000 derivative PBD 3 |
Mal-PEG8-Val-Ala |
[66] | |
SC16.52-DL3 |
SC16.52 |
Delta-like protein 3 (DLL3) |
SG2000 derivative PBD 3 |
Mal-PEG8-Val-Ala |
[66] | |
SC16.55-DL3 |
SC16.55 |
Delta-like protein 3 (DLL3) |
SG2000 derivative PBD 3 |
Mal-PEG8-Val-Ala |
[66] | |
SC16.56-DL3 |
SC16.56 |
Delta-like protein 3 (DLL3) |
SG2000 derivative PBD 3 |
Mal-PEG8-Val-Ala |
[66] | |
SC16.57-DL3 |
SC16.57 |
Delta-like protein 3 (DLL3) |
SG2000 derivative PBD 3 |
Mal-PEG8-Val-Ala |
[66] | |
SC16.58-DL3 |
SC16.58 |
Delta-like protein 3 (DLL3) |
SG2000 derivative PBD 3 |
Mal-PEG8-Val-Ala |
[66] | |
SC16.61-DL3 |
SC16.61 |
Delta-like protein 3 (DLL3) |
SG2000 derivative PBD 3 |
Mal-PEG8-Val-Ala |
[66] | |
SC16.62-DL3 |
SC16.62 |
Delta-like protein 3 (DLL3) |
SG2000 derivative PBD 3 |
Mal-PEG8-Val-Ala |
[66] | |
SC16.63-DL3 |
SC16.63 |
Delta-like protein 3 (DLL3) |
SG2000 derivative PBD 3 |
Mal-PEG8-Val-Ala |
[66] | |
SC16.65-DL3 |
SC16.65 |
Delta-like protein 3 (DLL3) |
SG2000 derivative PBD 3 |
Mal-PEG8-Val-Ala |
[66] | |
SC16.67-DL3 |
SC16.67 |
Delta-like protein 3 (DLL3) |
SG2000 derivative PBD 3 |
Mal-PEG8-Val-Ala |
[66] | |
SC16.68-DL3 |
SC16.68 |
Delta-like protein 3 (DLL3) |
SG2000 derivative PBD 3 |
Mal-PEG8-Val-Ala |
[66] | |
SC16.72-DL3 |
SC16.72 |
Delta-like protein 3 (DLL3) |
SG2000 derivative PBD 3 |
Mal-PEG8-Val-Ala |
[66] | |
SC16.73-DL3 |
SC16.73 |
Delta-like protein 3 (DLL3) |
SG2000 derivative PBD 3 |
Mal-PEG8-Val-Ala |
[66] | |
SC16.78-DL3 |
SC16.78 |
Delta-like protein 3 (DLL3) |
SG2000 derivative PBD 3 |
Mal-PEG8-Val-Ala |
[66] | |
SC16.79-DL3 |
SC16.79 |
Delta-like protein 3 (DLL3) |
SG2000 derivative PBD 3 |
Mal-PEG8-Val-Ala |
[66] | |
SC16.80-DL3 |
SC16.80 |
Delta-like protein 3 (DLL3) |
SG2000 derivative PBD 3 |
Mal-PEG8-Val-Ala |
[66] | |
SC16.81-DL3 |
SC16.81 |
Delta-like protein 3 (DLL3) |
SG2000 derivative PBD 3 |
Mal-PEG8-Val-Ala |
[66] | |
SC16.84-DL3 |
SC16.84 |
Delta-like protein 3 (DLL3) |
SG2000 derivative PBD 3 |
Mal-PEG8-Val-Ala |
[66] | |
SC16.88-DL3 |
SC16.88 |
Delta-like protein 3 (DLL3) |
SG2000 derivative PBD 3 |
Mal-PEG8-Val-Ala |
[66] | |
SC16.101-DL3 |
SC16.101 |
Delta-like protein 3 (DLL3) |
SG2000 derivative PBD 3 |
Mal-PEG8-Val-Ala |
[66] | |
SC16.103-DL3 |
SC16.103 |
Delta-like protein 3 (DLL3) |
SG2000 derivative PBD 3 |
Mal-PEG8-Val-Ala |
[66] | |
SC16.104-DL3 |
SC16.104 |
Delta-like protein 3 (DLL3) |
SG2000 derivative PBD 3 |
Mal-PEG8-Val-Ala |
[66] | |
SC16.105-DL3 |
SC16.105 |
Delta-like protein 3 (DLL3) |
SG2000 derivative PBD 3 |
Mal-PEG8-Val-Ala |
[66] | |
SC16.106-DL3 |
SC16.106 |
Delta-like protein 3 (DLL3) |
SG2000 derivative PBD 3 |
Mal-PEG8-Val-Ala |
[66] | |
SC16.107-DL3 |
SC16.107 |
Delta-like protein 3 (DLL3) |
SG2000 derivative PBD 3 |
Mal-PEG8-Val-Ala |
[66] | |
SC16.108-DL3 |
SC16.108 |
Delta-like protein 3 (DLL3) |
SG2000 derivative PBD 3 |
Mal-PEG8-Val-Ala |
[66] | |
SC16.109-DL3 |
SC16.109 |
Delta-like protein 3 (DLL3) |
SG2000 derivative PBD 3 |
Mal-PEG8-Val-Ala |
[66] | |
SC16.110-DL3 |
SC16.110 |
Delta-like protein 3 (DLL3) |
SG2000 derivative PBD 3 |
Mal-PEG8-Val-Ala |
[66] | |
SC16.111-DL3 |
SC16.111 |
Delta-like protein 3 (DLL3) |
SG2000 derivative PBD 3 |
Mal-PEG8-Val-Ala |
[66] | |
SC16.113-DL3 |
SC16.113 |
Delta-like protein 3 (DLL3) |
SG2000 derivative PBD 3 |
Mal-PEG8-Val-Ala |
[66] | |
SC16.114-DL3 |
SC16.114 |
Delta-like protein 3 (DLL3) |
SG2000 derivative PBD 3 |
Mal-PEG8-Val-Ala |
[66] | |
SC16.115-DL3 |
SC16.115 |
Delta-like protein 3 (DLL3) |
SG2000 derivative PBD 3 |
Mal-PEG8-Val-Ala |
[66] | |
SC16.116-DL3 |
SC16.116 |
Delta-like protein 3 (DLL3) |
SG2000 derivative PBD 3 |
Mal-PEG8-Val-Ala |
[66] | |
SC16.117-DL3 |
SC16.117 |
Delta-like protein 3 (DLL3) |
SG2000 derivative PBD 3 |
Mal-PEG8-Val-Ala |
[66] | |
SC16.118-DL3 |
SC16.118 |
Delta-like protein 3 (DLL3) |
SG2000 derivative PBD 3 |
Mal-PEG8-Val-Ala |
[66] | |
SC16.120-DL3 |
SC16.120 |
Delta-like protein 3 (DLL3) |
SG2000 derivative PBD 3 |
Mal-PEG8-Val-Ala |
[66] | |
SC16.121-DL3 |
SC16.121 |
Delta-like protein 3 (DLL3) |
SG2000 derivative PBD 3 |
Mal-PEG8-Val-Ala |
[66] | |
SC16.122-DL3 |
SC16.122 |
Delta-like protein 3 (DLL3) |
SG2000 derivative PBD 3 |
Mal-PEG8-Val-Ala |
[66] | |
SC16.123-DL3 |
SC16.123 |
Delta-like protein 3 (DLL3) |
SG2000 derivative PBD 3 |
Mal-PEG8-Val-Ala |
[66] | |
SC16.124-DL3 |
SC16.124 |
Delta-like protein 3 (DLL3) |
SG2000 derivative PBD 3 |
Mal-PEG8-Val-Ala |
[66] | |
SC16.125-DL3 |
SC16.125 |
Delta-like protein 3 (DLL3) |
SG2000 derivative PBD 3 |
Mal-PEG8-Val-Ala |
[66] | |
SC16.126-DL3 |
SC16.126 |
Delta-like protein 3 (DLL3) |
SG2000 derivative PBD 3 |
Mal-PEG8-Val-Ala |
[66] | |
SC16.129-DL3 |
SC16.129 |
Delta-like protein 3 (DLL3) |
SG2000 derivative PBD 3 |
Mal-PEG8-Val-Ala |
[66] | |
SC16.130-DL3 |
SC16.130 |
Delta-like protein 3 (DLL3) |
SG2000 derivative PBD 3 |
Mal-PEG8-Val-Ala |
[66] | |
SC16.131-DL3 |
SC16.131 |
Delta-like protein 3 (DLL3) |
SG2000 derivative PBD 3 |
Mal-PEG8-Val-Ala |
[66] | |
SC16.132-DL3 |
SC16.132 |
Delta-like protein 3 (DLL3) |
SG2000 derivative PBD 3 |
Mal-PEG8-Val-Ala |
[66] | |
SC16.133-DL3 |
SC16.133 |
Delta-like protein 3 (DLL3) |
SG2000 derivative PBD 3 |
Mal-PEG8-Val-Ala |
[66] | |
SC16.134-DL3 |
SC16.134 |
Delta-like protein 3 (DLL3) |
SG2000 derivative PBD 3 |
Mal-PEG8-Val-Ala |
[66] | |
SC16.135-DL3 |
SC16.135 |
Delta-like protein 3 (DLL3) |
SG2000 derivative PBD 3 |
Mal-PEG8-Val-Ala |
[66] | |
SC16.136-DL3 |
SC16.136 |
Delta-like protein 3 (DLL3) |
SG2000 derivative PBD 3 |
Mal-PEG8-Val-Ala |
[66] | |
SC16.137-DL3 |
SC16.137 |
Delta-like protein 3 (DLL3) |
SG2000 derivative PBD 3 |
Mal-PEG8-Val-Ala |
[66] | |
SC16.138-DL3 |
SC16.138 |
Delta-like protein 3 (DLL3) |
SG2000 derivative PBD 3 |
Mal-PEG8-Val-Ala |
[66] | |
SC16.139-DL3 |
SC16.139 |
Delta-like protein 3 (DLL3) |
SG2000 derivative PBD 3 |
Mal-PEG8-Val-Ala |
[66] | |
SC16.140-DL3 |
SC16.140 |
Delta-like protein 3 (DLL3) |
SG2000 derivative PBD 3 |
Mal-PEG8-Val-Ala |
[66] | |
SC16.141-DL3 |
SC16.141 |
Delta-like protein 3 (DLL3) |
SG2000 derivative PBD 3 |
Mal-PEG8-Val-Ala |
[66] | |
SC16.142-DL3 |
SC16.142 |
Delta-like protein 3 (DLL3) |
SG2000 derivative PBD 3 |
Mal-PEG8-Val-Ala |
[66] | |
SC16.143-DL3 |
SC16.143 |
Delta-like protein 3 (DLL3) |
SG2000 derivative PBD 3 |
Mal-PEG8-Val-Ala |
[66] | |
SC16.144-DL3 |
SC16.144 |
Delta-like protein 3 (DLL3) |
SG2000 derivative PBD 3 |
Mal-PEG8-Val-Ala |
[66] | |
SC16.147-DL3 |
SC16.147 |
Delta-like protein 3 (DLL3) |
SG2000 derivative PBD 3 |
Mal-PEG8-Val-Ala |
[66] | |
SC16.148-DL3 |
SC16.148 |
Delta-like protein 3 (DLL3) |
SG2000 derivative PBD 3 |
Mal-PEG8-Val-Ala |
[66] | |
SC16.149-DL3 |
SC16.149 |
Delta-like protein 3 (DLL3) |
SG2000 derivative PBD 3 |
Mal-PEG8-Val-Ala |
[66] | |
SC16.150-DL3 |
SC16.150 |
Delta-like protein 3 (DLL3) |
SG2000 derivative PBD 3 |
Mal-PEG8-Val-Ala |
[66] | |
SC16.3-DL4 |
SC16.3 |
Delta-like protein 3 (DLL3) |
SG2219 |
Iodoacetamide-PEG4-Val-Ala-PABC |
[66] | |
SC16.4-DL4 |
SC16.4 |
Delta-like protein 3 (DLL3) |
SG2219 |
Iodoacetamide-PEG4-Val-Ala-PABC |
[66] | |
SC16.5-DL4 |
SC16.5 |
Delta-like protein 3 (DLL3) |
SG2219 |
Iodoacetamide-PEG4-Val-Ala-PABC |
[66] | |
SC16.7-DL4 |
SC16.7 |
Delta-like protein 3 (DLL3) |
SG2219 |
Iodoacetamide-PEG4-Val-Ala-PABC |
[66] | |
SC16.8-DL4 |
SC16.8 |
Delta-like protein 3 (DLL3) |
SG2219 |
Iodoacetamide-PEG4-Val-Ala-PABC |
[66] | |
SC16.10-DL4 |
SC16.10 |
Delta-like protein 3 (DLL3) |
SG2219 |
Iodoacetamide-PEG4-Val-Ala-PABC |
[66] | |
SC16.11-DL4 |
SC16.11 |
Delta-like protein 3 (DLL3) |
SG2219 |
Iodoacetamide-PEG4-Val-Ala-PABC |
[66] | |
SC16.13-DL4 |
SC16.13 |
Delta-like protein 3 (DLL3) |
SG2219 |
Iodoacetamide-PEG4-Val-Ala-PABC |
[66] | |
SC16.15-DL4 |
SC16.15 |
Delta-like protein 3 (DLL3) |
SG2219 |
Iodoacetamide-PEG4-Val-Ala-PABC |
[66] | |
SC16.18-DL4 |
SC16.18 |
Delta-like protein 3 (DLL3) |
SG2219 |
Iodoacetamide-PEG4-Val-Ala-PABC |
[66] | |
SC16.19-DL4 |
SC16.19 |
Delta-like protein 3 (DLL3) |
SG2219 |
Iodoacetamide-PEG4-Val-Ala-PABC |
[66] | |
SC16.20-DL4 |
SC16.20 |
Delta-like protein 3 (DLL3) |
SG2219 |
Iodoacetamide-PEG4-Val-Ala-PABC |
[66] | |
SC16.21-DL4 |
SC16.21 |
Delta-like protein 3 (DLL3) |
SG2219 |
Iodoacetamide-PEG4-Val-Ala-PABC |
[66] | |
SC16.22-DL4 |
SC16.22 |
Delta-like protein 3 (DLL3) |
SG2219 |
Iodoacetamide-PEG4-Val-Ala-PABC |
[66] | |
SC16.23-DL4 |
SC16.23 |
Delta-like protein 3 (DLL3) |
SG2219 |
Iodoacetamide-PEG4-Val-Ala-PABC |
[66] | |
SC16.25-DL4 |
SC16.25 |
Delta-like protein 3 (DLL3) |
SG2219 |
Iodoacetamide-PEG4-Val-Ala-PABC |
[66] | |
SC16.26-DL4 |
SC16.26 |
Delta-like protein 3 (DLL3) |
SG2219 |
Iodoacetamide-PEG4-Val-Ala-PABC |
[66] | |
SC16.29-DL4 |
SC16.29 |
Delta-like protein 3 (DLL3) |
SG2219 |
Iodoacetamide-PEG4-Val-Ala-PABC |
[66] | |
SC16.30-DL4 |
SC16.30 |
Delta-like protein 3 (DLL3) |
SG2219 |
Iodoacetamide-PEG4-Val-Ala-PABC |
[66] | |
SC16.31-DL4 |
SC16.31 |
Delta-like protein 3 (DLL3) |
SG2219 |
Iodoacetamide-PEG4-Val-Ala-PABC |
[66] | |
SC16.34-DL4 |
SC16.34 |
Delta-like protein 3 (DLL3) |
SG2219 |
Iodoacetamide-PEG4-Val-Ala-PABC |
[66] | |
SC16.35-DL4 |
SC16.35 |
Delta-like protein 3 (DLL3) |
SG2219 |
Iodoacetamide-PEG4-Val-Ala-PABC |
[66] | |
SC16.36-DL4 |
SC16.36 |
Delta-like protein 3 (DLL3) |
SG2219 |
Iodoacetamide-PEG4-Val-Ala-PABC |
[66] | |
SC16.38-DL4 |
SC16.38 |
Delta-like protein 3 (DLL3) |
SG2219 |
Iodoacetamide-PEG4-Val-Ala-PABC |
[66] | |
SC16.41-DL4 |
SC16.41 |
Delta-like protein 3 (DLL3) |
SG2219 |
Iodoacetamide-PEG4-Val-Ala-PABC |
[66] | |
SC16.42-DL4 |
SC16.42 |
Delta-like protein 3 (DLL3) |
SG2219 |
Iodoacetamide-PEG4-Val-Ala-PABC |
[66] | |
SC16.45-DL4 |
SC16.45 |
Delta-like protein 3 (DLL3) |
SG2219 |
Iodoacetamide-PEG4-Val-Ala-PABC |
[66] | |
SC16.47-DL4 |
SC16.47 |
Delta-like protein 3 (DLL3) |
SG2219 |
Iodoacetamide-PEG4-Val-Ala-PABC |
[66] | |
SC16.49-DL4 |
SC16.49 |
Delta-like protein 3 (DLL3) |
SG2219 |
Iodoacetamide-PEG4-Val-Ala-PABC |
[66] | |
SC16.50-DL4 |
SC16.50 |
Delta-like protein 3 (DLL3) |
SG2219 |
Iodoacetamide-PEG4-Val-Ala-PABC |
[66] | |
SC16.52-DL4 |
SC16.52 |
Delta-like protein 3 (DLL3) |
SG2219 |
Iodoacetamide-PEG4-Val-Ala-PABC |
[66] | |
SC16.55-DL4 |
SC16.55 |
Delta-like protein 3 (DLL3) |
SG2219 |
Iodoacetamide-PEG4-Val-Ala-PABC |
[66] | |
SC16.56-DL4 |
SC16.56 |
Delta-like protein 3 (DLL3) |
SG2219 |
Iodoacetamide-PEG4-Val-Ala-PABC |
[66] | |
SC16.57-DL4 |
SC16.57 |
Delta-like protein 3 (DLL3) |
SG2219 |
Iodoacetamide-PEG4-Val-Ala-PABC |
[66] | |
SC16.58-DL4 |
SC16.58 |
Delta-like protein 3 (DLL3) |
SG2219 |
Iodoacetamide-PEG4-Val-Ala-PABC |
[66] | |
SC16.61-DL4 |
SC16.61 |
Delta-like protein 3 (DLL3) |
SG2219 |
Iodoacetamide-PEG4-Val-Ala-PABC |
[66] | |
SC16.62-DL4 |
SC16.62 |
Delta-like protein 3 (DLL3) |
SG2219 |
Iodoacetamide-PEG4-Val-Ala-PABC |
[66] | |
SC16.63-DL4 |
SC16.63 |
Delta-like protein 3 (DLL3) |
SG2219 |
Iodoacetamide-PEG4-Val-Ala-PABC |
[66] | |
SC16.65-DL4 |
SC16.65 |
Delta-like protein 3 (DLL3) |
SG2219 |
Iodoacetamide-PEG4-Val-Ala-PABC |
[66] | |
SC16.67-DL4 |
SC16.67 |
Delta-like protein 3 (DLL3) |
SG2219 |
Iodoacetamide-PEG4-Val-Ala-PABC |
[66] | |
SC16.68-DL4 |
SC16.68 |
Delta-like protein 3 (DLL3) |
SG2219 |
Iodoacetamide-PEG4-Val-Ala-PABC |
[66] | |
SC16.72-DL4 |
SC16.72 |
Delta-like protein 3 (DLL3) |
SG2219 |
Iodoacetamide-PEG4-Val-Ala-PABC |
[66] | |
SC16.73-DL4 |
SC16.73 |
Delta-like protein 3 (DLL3) |
SG2219 |
Iodoacetamide-PEG4-Val-Ala-PABC |
[66] | |
SC16.78-DL4 |
SC16.78 |
Delta-like protein 3 (DLL3) |
SG2219 |
Iodoacetamide-PEG4-Val-Ala-PABC |
[66] | |
SC16.79-DL4 |
SC16.79 |
Delta-like protein 3 (DLL3) |
SG2219 |
Iodoacetamide-PEG4-Val-Ala-PABC |
[66] | |
SC16.80-DL4 |
SC16.80 |
Delta-like protein 3 (DLL3) |
SG2219 |
Iodoacetamide-PEG4-Val-Ala-PABC |
[66] | |
SC16.81-DL4 |
SC16.81 |
Delta-like protein 3 (DLL3) |
SG2219 |
Iodoacetamide-PEG4-Val-Ala-PABC |
[66] | |
SC16.84-DL4 |
SC16.84 |
Delta-like protein 3 (DLL3) |
SG2219 |
Iodoacetamide-PEG4-Val-Ala-PABC |
[66] | |
SC16.88-DL4 |
SC16.88 |
Delta-like protein 3 (DLL3) |
SG2219 |
Iodoacetamide-PEG4-Val-Ala-PABC |
[66] | |
SC16.101-DL4 |
SC16.101 |
Delta-like protein 3 (DLL3) |
SG2219 |
Iodoacetamide-PEG4-Val-Ala-PABC |
[66] | |
SC16.103-DL4 |
SC16.103 |
Delta-like protein 3 (DLL3) |
SG2219 |
Iodoacetamide-PEG4-Val-Ala-PABC |
[66] | |
SC16.104-DL4 |
SC16.104 |
Delta-like protein 3 (DLL3) |
SG2219 |
Iodoacetamide-PEG4-Val-Ala-PABC |
[66] | |
SC16.105-DL4 |
SC16.105 |
Delta-like protein 3 (DLL3) |
SG2219 |
Iodoacetamide-PEG4-Val-Ala-PABC |
[66] | |
SC16.106-DL4 |
SC16.106 |
Delta-like protein 3 (DLL3) |
SG2219 |
Iodoacetamide-PEG4-Val-Ala-PABC |
[66] | |
SC16.107-DL4 |
SC16.107 |
Delta-like protein 3 (DLL3) |
SG2219 |
Iodoacetamide-PEG4-Val-Ala-PABC |
[66] | |
SC16.108-DL4 |
SC16.108 |
Delta-like protein 3 (DLL3) |
SG2219 |
Iodoacetamide-PEG4-Val-Ala-PABC |
[66] | |
SC16.109-DL4 |
SC16.109 |
Delta-like protein 3 (DLL3) |
SG2219 |
Iodoacetamide-PEG4-Val-Ala-PABC |
[66] | |
SC16.110-DL4 |
SC16.110 |
Delta-like protein 3 (DLL3) |
SG2219 |
Iodoacetamide-PEG4-Val-Ala-PABC |
[66] | |
SC16.111-DL4 |
SC16.111 |
Delta-like protein 3 (DLL3) |
SG2219 |
Iodoacetamide-PEG4-Val-Ala-PABC |
[66] | |
SC16.113-DL4 |
SC16.113 |
Delta-like protein 3 (DLL3) |
SG2219 |
Iodoacetamide-PEG4-Val-Ala-PABC |
[66] | |
SC16.114-DL4 |
SC16.114 |
Delta-like protein 3 (DLL3) |
SG2219 |
Iodoacetamide-PEG4-Val-Ala-PABC |
[66] | |
SC16.115-DL4 |
SC16.115 |
Delta-like protein 3 (DLL3) |
SG2219 |
Iodoacetamide-PEG4-Val-Ala-PABC |
[66] | |
SC16.116-DL4 |
SC16.116 |
Delta-like protein 3 (DLL3) |
SG2219 |
Iodoacetamide-PEG4-Val-Ala-PABC |
[66] | |
SC16.117-DL4 |
SC16.117 |
Delta-like protein 3 (DLL3) |
SG2219 |
Iodoacetamide-PEG4-Val-Ala-PABC |
[66] | |
SC16.118-DL4 |
SC16.118 |
Delta-like protein 3 (DLL3) |
SG2219 |
Iodoacetamide-PEG4-Val-Ala-PABC |
[66] | |
SC16.120-DL4 |
SC16.120 |
Delta-like protein 3 (DLL3) |
SG2219 |
Iodoacetamide-PEG4-Val-Ala-PABC |
[66] | |
SC16.121-DL4 |
SC16.121 |
Delta-like protein 3 (DLL3) |
SG2219 |
Iodoacetamide-PEG4-Val-Ala-PABC |
[66] | |
SC16.122-DL4 |
SC16.122 |
Delta-like protein 3 (DLL3) |
SG2219 |
Iodoacetamide-PEG4-Val-Ala-PABC |
[66] | |
SC16.123-DL4 |
SC16.123 |
Delta-like protein 3 (DLL3) |
SG2219 |
Iodoacetamide-PEG4-Val-Ala-PABC |
[66] | |
SC16.124-DL4 |
SC16.124 |
Delta-like protein 3 (DLL3) |
SG2219 |
Iodoacetamide-PEG4-Val-Ala-PABC |
[66] | |
SC16.125-DL4 |
SC16.125 |
Delta-like protein 3 (DLL3) |
SG2219 |
Iodoacetamide-PEG4-Val-Ala-PABC |
[66] | |
SC16.126-DL4 |
SC16.126 |
Delta-like protein 3 (DLL3) |
SG2219 |
Iodoacetamide-PEG4-Val-Ala-PABC |
[66] | |
SC16.129-DL4 |
SC16.129 |
Delta-like protein 3 (DLL3) |
SG2219 |
Iodoacetamide-PEG4-Val-Ala-PABC |
[66] | |
SC16.130-DL4 |
SC16.130 |
Delta-like protein 3 (DLL3) |
SG2219 |
Iodoacetamide-PEG4-Val-Ala-PABC |
[66] | |
SC16.131-DL4 |
SC16.131 |
Delta-like protein 3 (DLL3) |
SG2219 |
Iodoacetamide-PEG4-Val-Ala-PABC |
[66] | |
SC16.132-DL4 |
SC16.132 |
Delta-like protein 3 (DLL3) |
SG2219 |
Iodoacetamide-PEG4-Val-Ala-PABC |
[66] | |
SC16.133-DL4 |
SC16.133 |
Delta-like protein 3 (DLL3) |
SG2219 |
Iodoacetamide-PEG4-Val-Ala-PABC |
[66] | |
SC16.134-DL4 |
SC16.134 |
Delta-like protein 3 (DLL3) |
SG2219 |
Iodoacetamide-PEG4-Val-Ala-PABC |
[66] | |
SC16.135-DL4 |
SC16.135 |
Delta-like protein 3 (DLL3) |
SG2219 |
Iodoacetamide-PEG4-Val-Ala-PABC |
[66] | |
SC16.136-DL4 |
SC16.136 |
Delta-like protein 3 (DLL3) |
SG2219 |
Iodoacetamide-PEG4-Val-Ala-PABC |
[66] | |
SC16.137-DL4 |
SC16.137 |
Delta-like protein 3 (DLL3) |
SG2219 |
Iodoacetamide-PEG4-Val-Ala-PABC |
[66] | |
SC16.138-DL4 |
SC16.138 |
Delta-like protein 3 (DLL3) |
SG2219 |
Iodoacetamide-PEG4-Val-Ala-PABC |
[66] | |
SC16.139-DL4 |
SC16.139 |
Delta-like protein 3 (DLL3) |
SG2219 |
Iodoacetamide-PEG4-Val-Ala-PABC |
[66] | |
SC16.140-DL4 |
SC16.140 |
Delta-like protein 3 (DLL3) |
SG2219 |
Iodoacetamide-PEG4-Val-Ala-PABC |
[66] | |
SC16.141-DL4 |
SC16.141 |
Delta-like protein 3 (DLL3) |
SG2219 |
Iodoacetamide-PEG4-Val-Ala-PABC |
[66] | |
SC16.142-DL4 |
SC16.142 |
Delta-like protein 3 (DLL3) |
SG2219 |
Iodoacetamide-PEG4-Val-Ala-PABC |
[66] | |
SC16.143-DL4 |
SC16.143 |
Delta-like protein 3 (DLL3) |
SG2219 |
Iodoacetamide-PEG4-Val-Ala-PABC |
[66] | |
SC16.144-DL4 |
SC16.144 |
Delta-like protein 3 (DLL3) |
SG2219 |
Iodoacetamide-PEG4-Val-Ala-PABC |
[66] | |
SC16.147-DL4 |
SC16.147 |
Delta-like protein 3 (DLL3) |
SG2219 |
Iodoacetamide-PEG4-Val-Ala-PABC |
[66] | |
SC16.148-DL4 |
SC16.148 |
Delta-like protein 3 (DLL3) |
SG2219 |
Iodoacetamide-PEG4-Val-Ala-PABC |
[66] | |
SC16.149-DL4 |
SC16.149 |
Delta-like protein 3 (DLL3) |
SG2219 |
Iodoacetamide-PEG4-Val-Ala-PABC |
[66] | |
SC16.150-DL4 |
SC16.150 |
Delta-like protein 3 (DLL3) |
SG2219 |
Iodoacetamide-PEG4-Val-Ala-PABC |
[66] | |
SC16.3-DL5 |
SC16.3 |
Delta-like protein 3 (DLL3) |
SG3199 |
Mc-PEG8-Val-Ala-PABC |
[66] | |
SC16.4-DL5 |
SC16.4 |
Delta-like protein 3 (DLL3) |
SG3199 |
Mc-PEG8-Val-Ala-PABC |
[66] | |
SC16.5-DL5 |
SC16.5 |
Delta-like protein 3 (DLL3) |
SG3199 |
Mc-PEG8-Val-Ala-PABC |
[66] | |
SC16.7-DL5 |
SC16.7 |
Delta-like protein 3 (DLL3) |
SG3199 |
Mc-PEG8-Val-Ala-PABC |
[66] | |
SC16.8-DL5 |
SC16.8 |
Delta-like protein 3 (DLL3) |
SG3199 |
Mc-PEG8-Val-Ala-PABC |
[66] | |
SC16.10-DL5 |
SC16.10 |
Delta-like protein 3 (DLL3) |
SG3199 |
Mc-PEG8-Val-Ala-PABC |
[66] | |
SC16.11-DL5 |
SC16.11 |
Delta-like protein 3 (DLL3) |
SG3199 |
Mc-PEG8-Val-Ala-PABC |
[66] | |
SC16.13-DL5 |
SC16.13 |
Delta-like protein 3 (DLL3) |
SG3199 |
Mc-PEG8-Val-Ala-PABC |
[66] | |
SC16.15-DL5 |
SC16.15 |
Delta-like protein 3 (DLL3) |
SG3199 |
Mc-PEG8-Val-Ala-PABC |
[66] | |
SC16.18-DL5 |
SC16.18 |
Delta-like protein 3 (DLL3) |
SG3199 |
Mc-PEG8-Val-Ala-PABC |
[66] | |
SC16.19-DL5 |
SC16.19 |
Delta-like protein 3 (DLL3) |
SG3199 |
Mc-PEG8-Val-Ala-PABC |
[66] | |
SC16.20-DL5 |
SC16.20 |
Delta-like protein 3 (DLL3) |
SG3199 |
Mc-PEG8-Val-Ala-PABC |
[66] | |
SC16.21-DL5 |
SC16.21 |
Delta-like protein 3 (DLL3) |
SG3199 |
Mc-PEG8-Val-Ala-PABC |
[66] | |
SC16.22-DL5 |
SC16.22 |
Delta-like protein 3 (DLL3) |
SG3199 |
Mc-PEG8-Val-Ala-PABC |
[66] | |
SC16.23-DL5 |
SC16.23 |
Delta-like protein 3 (DLL3) |
SG3199 |
Mc-PEG8-Val-Ala-PABC |
[66] | |
SC16.25-DL5 |
SC16.25 |
Delta-like protein 3 (DLL3) |
SG3199 |
Mc-PEG8-Val-Ala-PABC |
[66] | |
SC16.26-DL5 |
SC16.26 |
Delta-like protein 3 (DLL3) |
SG3199 |
Mc-PEG8-Val-Ala-PABC |
[66] | |
SC16.29-DL5 |
SC16.29 |
Delta-like protein 3 (DLL3) |
SG3199 |
Mc-PEG8-Val-Ala-PABC |
[66] | |
SC16.30-DL5 |
SC16.30 |
Delta-like protein 3 (DLL3) |
SG3199 |
Mc-PEG8-Val-Ala-PABC |
[66] | |
SC16.31-DL5 |
SC16.31 |
Delta-like protein 3 (DLL3) |
SG3199 |
Mc-PEG8-Val-Ala-PABC |
[66] | |
SC16.34-DL5 |
SC16.34 |
Delta-like protein 3 (DLL3) |
SG3199 |
Mc-PEG8-Val-Ala-PABC |
[66] | |
SC16.35-DL5 |
SC16.35 |
Delta-like protein 3 (DLL3) |
SG3199 |
Mc-PEG8-Val-Ala-PABC |
[66] | |
SC16.36-DL5 |
SC16.36 |
Delta-like protein 3 (DLL3) |
SG3199 |
Mc-PEG8-Val-Ala-PABC |
[66] | |
SC16.38-DL5 |
SC16.38 |
Delta-like protein 3 (DLL3) |
SG3199 |
Mc-PEG8-Val-Ala-PABC |
[66] | |
SC16.41-DL5 |
SC16.41 |
Delta-like protein 3 (DLL3) |
SG3199 |
Mc-PEG8-Val-Ala-PABC |
[66] | |
SC16.42-DL5 |
SC16.42 |
Delta-like protein 3 (DLL3) |
SG3199 |
Mc-PEG8-Val-Ala-PABC |
[66] | |
SC16.45-DL5 |
SC16.45 |
Delta-like protein 3 (DLL3) |
SG3199 |
Mc-PEG8-Val-Ala-PABC |
[66] | |
SC16.47-DL5 |
SC16.47 |
Delta-like protein 3 (DLL3) |
SG3199 |
Mc-PEG8-Val-Ala-PABC |
[66] | |
SC16.49-DL5 |
SC16.49 |
Delta-like protein 3 (DLL3) |
SG3199 |
Mc-PEG8-Val-Ala-PABC |
[66] | |
SC16.50-DL5 |
SC16.50 |
Delta-like protein 3 (DLL3) |
SG3199 |
Mc-PEG8-Val-Ala-PABC |
[66] | |
SC16.52-DL5 |
SC16.52 |
Delta-like protein 3 (DLL3) |
SG3199 |
Mc-PEG8-Val-Ala-PABC |
[66] | |
SC16.55-DL5 |
SC16.55 |
Delta-like protein 3 (DLL3) |
SG3199 |
Mc-PEG8-Val-Ala-PABC |
[66] | |
SC16.56-DL5 |
SC16.56 |
Delta-like protein 3 (DLL3) |
SG3199 |
Mc-PEG8-Val-Ala-PABC |
[66] | |
SC16.57-DL5 |
SC16.57 |
Delta-like protein 3 (DLL3) |
SG3199 |
Mc-PEG8-Val-Ala-PABC |
[66] | |
SC16.58-DL5 |
SC16.58 |
Delta-like protein 3 (DLL3) |
SG3199 |
Mc-PEG8-Val-Ala-PABC |
[66] | |
SC16.61-DL5 |
SC16.61 |
Delta-like protein 3 (DLL3) |
SG3199 |
Mc-PEG8-Val-Ala-PABC |
[66] | |
SC16.62-DL5 |
SC16.62 |
Delta-like protein 3 (DLL3) |
SG3199 |
Mc-PEG8-Val-Ala-PABC |
[66] | |
SC16.63-DL5 |
SC16.63 |
Delta-like protein 3 (DLL3) |
SG3199 |
Mc-PEG8-Val-Ala-PABC |
[66] | |
SC16.65-DL5 |
SC16.65 |
Delta-like protein 3 (DLL3) |
SG3199 |
Mc-PEG8-Val-Ala-PABC |
[66] | |
SC16.67-DL5 |
SC16.67 |
Delta-like protein 3 (DLL3) |
SG3199 |
Mc-PEG8-Val-Ala-PABC |
[66] | |
SC16.68-DL5 |
SC16.68 |
Delta-like protein 3 (DLL3) |
SG3199 |
Mc-PEG8-Val-Ala-PABC |
[66] | |
SC16.72-DL5 |
SC16.72 |
Delta-like protein 3 (DLL3) |
SG3199 |
Mc-PEG8-Val-Ala-PABC |
[66] | |
SC16.73-DL5 |
SC16.73 |
Delta-like protein 3 (DLL3) |
SG3199 |
Mc-PEG8-Val-Ala-PABC |
[66] | |
SC16.78-DL5 |
SC16.78 |
Delta-like protein 3 (DLL3) |
SG3199 |
Mc-PEG8-Val-Ala-PABC |
[66] | |
SC16.79-DL5 |
SC16.79 |
Delta-like protein 3 (DLL3) |
SG3199 |
Mc-PEG8-Val-Ala-PABC |
[66] | |
SC16.80-DL5 |
SC16.80 |
Delta-like protein 3 (DLL3) |
SG3199 |
Mc-PEG8-Val-Ala-PABC |
[66] | |
SC16.81-DL5 |
SC16.81 |
Delta-like protein 3 (DLL3) |
SG3199 |
Mc-PEG8-Val-Ala-PABC |
[66] | |
SC16.84-DL5 |
SC16.84 |
Delta-like protein 3 (DLL3) |
SG3199 |
Mc-PEG8-Val-Ala-PABC |
[66] | |
SC16.88-DL5 |
SC16.88 |
Delta-like protein 3 (DLL3) |
SG3199 |
Mc-PEG8-Val-Ala-PABC |
[66] | |
SC16.101-DL5 |
SC16.101 |
Delta-like protein 3 (DLL3) |
SG3199 |
Mc-PEG8-Val-Ala-PABC |
[66] | |
SC16.103-DL5 |
SC16.103 |
Delta-like protein 3 (DLL3) |
SG3199 |
Mc-PEG8-Val-Ala-PABC |
[66] | |
SC16.104-DL5 |
SC16.104 |
Delta-like protein 3 (DLL3) |
SG3199 |
Mc-PEG8-Val-Ala-PABC |
[66] | |
SC16.105-DL5 |
SC16.105 |
Delta-like protein 3 (DLL3) |
SG3199 |
Mc-PEG8-Val-Ala-PABC |
[66] | |
SC16.106-DL5 |
SC16.106 |
Delta-like protein 3 (DLL3) |
SG3199 |
Mc-PEG8-Val-Ala-PABC |
[66] | |
SC16.107-DL5 |
SC16.107 |
Delta-like protein 3 (DLL3) |
SG3199 |
Mc-PEG8-Val-Ala-PABC |
[66] | |
SC16.108-DL5 |
SC16.108 |
Delta-like protein 3 (DLL3) |
SG3199 |
Mc-PEG8-Val-Ala-PABC |
[66] | |
SC16.109-DL5 |
SC16.109 |
Delta-like protein 3 (DLL3) |
SG3199 |
Mc-PEG8-Val-Ala-PABC |
[66] | |
SC16.110-DL5 |
SC16.110 |
Delta-like protein 3 (DLL3) |
SG3199 |
Mc-PEG8-Val-Ala-PABC |
[66] | |
SC16.111-DL5 |
SC16.111 |
Delta-like protein 3 (DLL3) |
SG3199 |
Mc-PEG8-Val-Ala-PABC |
[66] | |
SC16.113-DL5 |
SC16.113 |
Delta-like protein 3 (DLL3) |
SG3199 |
Mc-PEG8-Val-Ala-PABC |
[66] | |
SC16.114-DL5 |
SC16.114 |
Delta-like protein 3 (DLL3) |
SG3199 |
Mc-PEG8-Val-Ala-PABC |
[66] | |
SC16.115-DL5 |
SC16.115 |
Delta-like protein 3 (DLL3) |
SG3199 |
Mc-PEG8-Val-Ala-PABC |
[66] | |
SC16.116-DL5 |
SC16.116 |
Delta-like protein 3 (DLL3) |
SG3199 |
Mc-PEG8-Val-Ala-PABC |
[66] | |
SC16.117-DL5 |
SC16.117 |
Delta-like protein 3 (DLL3) |
SG3199 |
Mc-PEG8-Val-Ala-PABC |
[66] | |
SC16.118-DL5 |
SC16.118 |
Delta-like protein 3 (DLL3) |
SG3199 |
Mc-PEG8-Val-Ala-PABC |
[66] | |
SC16.120-DL5 |
SC16.120 |
Delta-like protein 3 (DLL3) |
SG3199 |
Mc-PEG8-Val-Ala-PABC |
[66] | |
SC16.121-DL5 |
SC16.121 |
Delta-like protein 3 (DLL3) |
SG3199 |
Mc-PEG8-Val-Ala-PABC |
[66] | |
SC16.122-DL5 |
SC16.122 |
Delta-like protein 3 (DLL3) |
SG3199 |
Mc-PEG8-Val-Ala-PABC |
[66] | |
SC16.123-DL5 |
SC16.123 |
Delta-like protein 3 (DLL3) |
SG3199 |
Mc-PEG8-Val-Ala-PABC |
[66] | |
SC16.124-DL5 |
SC16.124 |
Delta-like protein 3 (DLL3) |
SG3199 |
Mc-PEG8-Val-Ala-PABC |
[66] | |
SC16.125-DL5 |
SC16.125 |
Delta-like protein 3 (DLL3) |
SG3199 |
Mc-PEG8-Val-Ala-PABC |
[66] | |
SC16.126-DL5 |
SC16.126 |
Delta-like protein 3 (DLL3) |
SG3199 |
Mc-PEG8-Val-Ala-PABC |
[66] | |
SC16.129-DL5 |
SC16.129 |
Delta-like protein 3 (DLL3) |
SG3199 |
Mc-PEG8-Val-Ala-PABC |
[66] | |
SC16.130-DL5 |
SC16.130 |
Delta-like protein 3 (DLL3) |
SG3199 |
Mc-PEG8-Val-Ala-PABC |
[66] | |
SC16.131-DL5 |
SC16.131 |
Delta-like protein 3 (DLL3) |
SG3199 |
Mc-PEG8-Val-Ala-PABC |
[66] | |
SC16.132-DL5 |
SC16.132 |
Delta-like protein 3 (DLL3) |
SG3199 |
Mc-PEG8-Val-Ala-PABC |
[66] | |
SC16.133-DL5 |
SC16.133 |
Delta-like protein 3 (DLL3) |
SG3199 |
Mc-PEG8-Val-Ala-PABC |
[66] | |
SC16.134-DL5 |
SC16.134 |
Delta-like protein 3 (DLL3) |
SG3199 |
Mc-PEG8-Val-Ala-PABC |
[66] | |
SC16.135-DL5 |
SC16.135 |
Delta-like protein 3 (DLL3) |
SG3199 |
Mc-PEG8-Val-Ala-PABC |
[66] | |
SC16.136-DL5 |
SC16.136 |
Delta-like protein 3 (DLL3) |
SG3199 |
Mc-PEG8-Val-Ala-PABC |
[66] | |
SC16.137-DL5 |
SC16.137 |
Delta-like protein 3 (DLL3) |
SG3199 |
Mc-PEG8-Val-Ala-PABC |
[66] | |
SC16.138-DL5 |
SC16.138 |
Delta-like protein 3 (DLL3) |
SG3199 |
Mc-PEG8-Val-Ala-PABC |
[66] | |
SC16.139-DL5 |
SC16.139 |
Delta-like protein 3 (DLL3) |
SG3199 |
Mc-PEG8-Val-Ala-PABC |
[66] | |
SC16.140-DL5 |
SC16.140 |
Delta-like protein 3 (DLL3) |
SG3199 |
Mc-PEG8-Val-Ala-PABC |
[66] | |
SC16.141-DL5 |
SC16.141 |
Delta-like protein 3 (DLL3) |
SG3199 |
Mc-PEG8-Val-Ala-PABC |
[66] | |
SC16.142-DL5 |
SC16.142 |
Delta-like protein 3 (DLL3) |
SG3199 |
Mc-PEG8-Val-Ala-PABC |
[66] | |
SC16.143-DL5 |
SC16.143 |
Delta-like protein 3 (DLL3) |
SG3199 |
Mc-PEG8-Val-Ala-PABC |
[66] | |
SC16.144-DL5 |
SC16.144 |
Delta-like protein 3 (DLL3) |
SG3199 |
Mc-PEG8-Val-Ala-PABC |
[66] | |
SC16.147-DL5 |
SC16.147 |
Delta-like protein 3 (DLL3) |
SG3199 |
Mc-PEG8-Val-Ala-PABC |
[66] | |
SC16.148-DL5 |
SC16.148 |
Delta-like protein 3 (DLL3) |
SG3199 |
Mc-PEG8-Val-Ala-PABC |
[66] | |
SC16.149-DL5 |
SC16.149 |
Delta-like protein 3 (DLL3) |
SG3199 |
Mc-PEG8-Val-Ala-PABC |
[66] | |
SC16.150-DL5 |
SC16.150 |
Delta-like protein 3 (DLL3) |
SG3199 |
Mc-PEG8-Val-Ala-PABC |
[66] | |
HuM25-S239C-PBD-E2 |
huM25-S239C |
Leucine-rich repeat-containing protein 15 (LRRC15) |
PBD dimer |
Mc-Val-Ala |
[67] | |
HuAD208.4.1-PBD-DAR2 |
huAD208.4.1 |
Leucine-rich repeat-containing protein 15 (LRRC15) |
PBD dimer |
Mc-Val-Ala |
[67] | |
ABT-700 (S238C)-PBD |
Telisotuzumab |
Hepatocyte growth factor receptor (MET) |
PBD dimer |
Mc-Val-Ala |
[68] | |
ADC Trast-14 |
Trastuzumab |
Receptor tyrosine-protein kinase erbB-2 (ERBB2) |
PBD dimer 3 |
Undisclosed |
[69] | |
ADC Trast-11 |
Trastuzumab |
Receptor tyrosine-protein kinase erbB-2 (ERBB2) |
PBD dimer 3 |
Bis-BCN-modified Val-Cit-PABC linker 10 |
[69] | |
Anti-ApoD PBD |
Anti-ApoD Anti-ody |
Apolipoprotein D (APOD) |
PBD dimer |
Undisclosed |
[70] | |
SNS-622-DUO |
SNS-622 |
Aspartyl/asparaginyl beta-hydroxylase (ASPH) |
Duocarmycin A |
Mc-Val-Cit-PABC |
[71] | |
DAB4-DuoDM |
DAB4 |
Lupus La protein (SSB) |
DEAEA duocarmycin |
Mal-PEG4-Val-Cit-PABC |
[72] | |
Sal5-DuoDM |
Sal5 |
Epidermal growth factor receptor (EGFR); Receptor tyrosine-protein kinase erbB-3 (ERBB3) |
DEAEA duocarmycin |
Mal-PEG4-Val-Cit-PABC |
[72] | |
ChDAB4-SG3249 |
Chimeric DAB4 (chDAB4) |
Lupus La protein (SSB) |
SG3199 |
Mal-PEG8-Val-Ala-PABC |
[72] | |
B12-SG3249 |
B12 |
Envelope glycoprotein gp160 (env) |
SG3199 |
Mal-PEG8-Val-Ala-PABC |
[72] | |
Rituximab-DNA conjugate |
Rituximab |
B-lymphocyte antigen CD20 (MS4A1) |
DNA mimics |
Undisclosed |
[73] | |
Cetuximab-DNA conjugate |
Cetuximab |
Epidermal growth factor receptor (EGFR) |
DNA mimics |
Undisclosed |
[73] | |
Panitumumab-DNA conjugate |
Panitumumab |
Epidermal growth factor receptor (EGFR) |
DNA mimics |
Undisclosed |
[73] | |
Trastuzumab-DNA conjugate |
Trastuzumab |
Receptor tyrosine-protein kinase erbB-2 (ERBB2) |
DNA mimics |
Undisclosed |
[73] | |
OHPAS ADC-2 |
Trastuzumab |
Receptor tyrosine-protein kinase erbB-2 (ERBB2) |
SG2000 |
Ortho-hydroxy-protected aryl sulfate |
[74] | |
OHPAS ADC-3 |
Trastuzumab |
Receptor tyrosine-protein kinase erbB-2 (ERBB2) |
seco-CBI-indole |
Ortho-hydroxy-protected aryl sulfate |
[74] | |
OHPAS ADC-4 |
Trastuzumab |
Receptor tyrosine-protein kinase erbB-2 (ERBB2) |
CBI-dimer-beta-Gal |
Ortho-hydroxy-protected aryl sulfate |
[74] | |
AF-GPL |
Anti-ody fragment (AF) |
Epidermal growth factor receptor (EGFR); Receptor tyrosine-protein kinase erbB-3 (ERBB3) |
Gemcitabine and paclitaxel loaded liposome |
Undisclosed |
[75] | |
HmAb-C-DUBA |
hmAb-C |
CD276 antigen (CD276) |
seco-DUBA |
Mal-PEG2-Val-Cit-PABA-Cyclization Spacer |
[76] | |
Alpha-HER2-Duo 405 |
Anti-HER2 mAb |
Receptor tyrosine-protein kinase erbB-2 (ERBB2) |
Duocarmycin 405 |
Undisclosed |
[77] | |
WO2021044208A1 ADC6 |
Anti-ROR1 mAb C2E3 |
Inactive tyrosine-protein kinase transmembrane receptor ROR1 (ROR1) |
SG2000 |
WO2021044208A1_ADC6 linker |
[7] | |
WO2021044208A1 ADC7 |
Anti-ROR1 mAb C2E3 |
Inactive tyrosine-protein kinase transmembrane receptor ROR1 (ROR1) |
SG2000 |
WO2021044208A1_ADC7 linker |
[7] | |
WO2021044208A1 ADC8 |
Anti-ROR1 mAb C2E3 |
Inactive tyrosine-protein kinase transmembrane receptor ROR1 (ROR1) |
SG2000 |
WO2021044208A1_ADC8 linker |
[7] | |
WO2021044208A1 ADC 2A2-6 |
Anti-ROR1 mAb 2A2 |
Inactive tyrosine-protein kinase transmembrane receptor ROR1 (ROR1) |
SG2000 |
WO2021044208A1_ADC 2A2-6 linker |
[7] | |
WO2021044208A1 ADC 2A2-7 |
Anti-ROR1 mAb 2A2 |
Inactive tyrosine-protein kinase transmembrane receptor ROR1 (ROR1) |
SG2000 |
WO2021044208A1_ADC 2A2-7 linker |
[7] | |
WO2021044208A1 ADC AB4-1 |
Anti-ROR1 mAb 2A2 |
Inactive tyrosine-protein kinase transmembrane receptor ROR1 (ROR1) |
SG2000 |
WO2021044208A1_ADC AB4-1 linker |
[7] | |
WO2021044208A1 ADC AB4-6 |
Anti-ROR1 mAb AB4 |
Inactive tyrosine-protein kinase transmembrane receptor ROR1 (ROR1) |
SG2000 |
WO2021044208A1_ADC AB4-6 linker |
[7] | |
WO2021044208A1 ADC AB4-7 |
Anti-ROR1 mAb AB4 |
Inactive tyrosine-protein kinase transmembrane receptor ROR1 (ROR1) |
SG2000 |
WO2021044208A1_ADC AB4-7 linker |
[7] | |
WO2021044208A1 ADC A2F2-1 |
Anti-ROR1 mAb AB4 |
Inactive tyrosine-protein kinase transmembrane receptor ROR1 (ROR1) |
SG2000 |
WO2021044208A1_ADC A2F2-1 linker |
[7] | |
WO2021044208A1 ADC A2F2-6 |
Anti-ROR1 mAb A2F2 |
Inactive tyrosine-protein kinase transmembrane receptor ROR1 (ROR1) |
SG2000 |
WO2021044208A1_ADC A2F2-6 linker |
[7] | |
WO2021044208A1 ADC A2F2-7 |
Anti-ROR1 mAb A2F2 |
Inactive tyrosine-protein kinase transmembrane receptor ROR1 (ROR1) |
SG2000 |
WO2021044208A1_ADC A2F2-7 linker |
[7] | |
WO2021044208A1 ADC A2F3-1 |
Anti-ROR1 mAb A2F2 |
Inactive tyrosine-protein kinase transmembrane receptor ROR1 (ROR1) |
SG2000 |
WO2021044208A1_ADC A2F3-1 linker |
[7] | |
WO2021044208A1 ADC A2F3-6 |
Anti-ROR1 mAb A2F3 |
Inactive tyrosine-protein kinase transmembrane receptor ROR1 (ROR1) |
SG2000 |
WO2021044208A1_ADC A2F3-6 linker |
[7] | |
WO2021044208A1 ADC A2F3-7 |
Anti-ROR1 mAb A2F3 |
Inactive tyrosine-protein kinase transmembrane receptor ROR1 (ROR1) |
SG2000 |
WO2021044208A1_ADC A2F3-7 linker |
[7] | |
WO2021044208A1 ADC BA6-1 |
Anti-ROR1 mAb A2F3 |
Inactive tyrosine-protein kinase transmembrane receptor ROR1 (ROR1) |
SG2000 |
WO2021044208A1_ADC BA6-1 linker |
[7] | |
WO2021044208A1 ADC BA6-6 |
Anti-ROR1 mAb BA6 |
Inactive tyrosine-protein kinase transmembrane receptor ROR1 (ROR1) |
SG2000 |
WO2021044208A1_ADC BA6-6 linker |
[7] | |
WO2021044208A1 ADC BA6-7 |
Anti-ROR1 mAb BA6 |
Inactive tyrosine-protein kinase transmembrane receptor ROR1 (ROR1) |
SG2000 |
WO2021044208A1_ADC BA6-7 linker |
[7] | |
WO2021044208A1 ADC CC9-1 |
Anti-ROR1 mAb BA6 |
Inactive tyrosine-protein kinase transmembrane receptor ROR1 (ROR1) |
SG2000 |
WO2021044208A1_ADC CC9-1 linker |
[7] | |
WO2021044208A1 ADC CC9-6 |
Anti-ROR1 mAb CC9 |
Inactive tyrosine-protein kinase transmembrane receptor ROR1 (ROR1) |
SG2000 |
WO2021044208A1_ADC CC9-6 linker |
[7] | |
WO2021044208A1 ADC CC9-7 |
Anti-ROR1 mAb CC9 |
Inactive tyrosine-protein kinase transmembrane receptor ROR1 (ROR1) |
SG2000 |
WO2021044208A1_ADC CC9-7 linker |
[7] | |
WO2021044208A1 ADC DG6-1 |
Anti-ROR1 mAb CC9 |
Inactive tyrosine-protein kinase transmembrane receptor ROR1 (ROR1) |
SG2000 |
WO2021044208A1_ADC DG6-1 linker |
[7] | |
WO2021044208A1 ADC DG6-6 |
Anti-ROR1 mAb DG6 |
Inactive tyrosine-protein kinase transmembrane receptor ROR1 (ROR1) |
SG2000 |
WO2021044208A1_ADC DG6-6 linker |
[7] | |
WO2021044208A1 ADC DG6-7 |
Anti-ROR1 mAb DG6 |
Inactive tyrosine-protein kinase transmembrane receptor ROR1 (ROR1) |
SG2000 |
WO2021044208A1_ADC DG6-7 linker |
[7] | |
WO2021044208A1 ADC D2B12-1 |
Anti-ROR1 mAb DG6 |
Inactive tyrosine-protein kinase transmembrane receptor ROR1 (ROR1) |
SG2000 |
WO2021044208A1_ADC D2B12-1 linker |
[7] | |
WO2021044208A1 ADC D2B12-6 |
Anti-ROR1 mAb D2B12 |
Inactive tyrosine-protein kinase transmembrane receptor ROR1 (ROR1) |
SG2000 |
WO2021044208A1_ADC D2B12-6 linker |
[7] | |
WO2021044208A1 ADC D2B12-7 |
Anti-ROR1 mAb D2B12 |
Inactive tyrosine-protein kinase transmembrane receptor ROR1 (ROR1) |
SG2000 |
WO2021044208A1_ADC D2B12-7 linker |
[7] | |
WO2021044208A1 ADC A2F2 M1-1 |
Anti-ROR1 mAb D2B12 |
Inactive tyrosine-protein kinase transmembrane receptor ROR1 (ROR1) |
SG2000 |
WO2021044208A1_ADC A2F2 M1-1 linker |
[7] | |
WO2021044208A1 ADC A2F2 M1-7 |
Anti-ROR1 mAb A2F2 M1 |
Inactive tyrosine-protein kinase transmembrane receptor ROR1 (ROR1) |
SG2000 |
WO2021044208A1_ADC A2F2 M1-7 linker |
[7] | |
WO2013055987A1 Tmab-101 |
Trastuzumab |
Receptor tyrosine-protein kinase erbB-2 (ERBB2) |
SG2000 |
WO2013055987A1_Tmab-101 linker |
[78] | |
WO2013055987A1 Tmab-102 |
Trastuzumab |
Receptor tyrosine-protein kinase erbB-2 (ERBB2) |
SG2000 |
WO2013055987A1_Tmab-102 linker |
[78] | |
WO2013055987A1 xCD22-103 |
Anti-CD22 mAb xCD22 |
B-cell receptor CD22 (CD22) |
SG2000 |
WO2013055987A1_xCD22-103 linker |
[78] | |
WO2013055987A1 Tmab-104 |
Trastuzumab |
Receptor tyrosine-protein kinase erbB-2 (ERBB2) |
SG2000 |
WO2013055987A1_Tmab-104 linker |
[78] | |
WO2013055987A1 Tmab-110 |
Trastuzumab |
Receptor tyrosine-protein kinase erbB-2 (ERBB2) |
SG2000 |
WO2013055987A1_Tmab-110 linker |
[78] | |
Anti-c-Met IgG-OXA |
Anti-MET mAb |
Hepatocyte growth factor receptor (MET) |
Oxaliplatin |
Dipeptide-p-amidobenzyl alcohol linker |
[79] | |
Dualtargeting lidamycin ADC |
Undisclosed |
Epidermal growth factor receptor (EGFR); Receptor tyrosine-protein kinase erbB-2 (ERBB2) |
Lidamycin |
Undisclosed |
[80] | |
PF-06888667 |
Trastuzumab |
Receptor tyrosine-protein kinase erbB-2 (ERBB2) |
SW-163D |
AcLys-Val-Cit-PABC-DMAE |
[81] | |
Anti-FOLR1-Ala-Ala-IGN |
Anti-FOLR1 mAb |
Folate receptor alpha (FOLR1) |
Indolinobenzodiazepine dimer |
Ala-Ala dipeptide |
[82] | |
Anti-FOLR1-Val-Gln-IGN |
Anti-FOLR1 mAb |
Folate receptor alpha (FOLR1) |
Indolinobenzodiazepine dimer |
Val-Gln dipeptide linker |
[82] | |
Anti-EGFR-Ala-Ala-IGN |
Anti-EGFR mAb |
Epidermal growth factor receptor (EGFR) |
Indolinobenzodiazepine dimer |
Ala-Ala dipeptide |
[82] | |
Anti-EGFR-Val-Gln-IGN |
Anti-EGFR mAb |
Epidermal growth factor receptor (EGFR) |
Indolinobenzodiazepine dimer |
Val-Gln dipeptide linker |
[82] | |
Tb074-SG3376 |
Anti-HpHbR mAb Tb074 |
Haptoglobin-hemoglobin receptor (Tb06.28F21.220) |
PBD dimer SG3552 |
Mal-PEG4 |
[83] | |
Tb085-SG3376 |
Anti-HpHbR mAb Tb085 |
Haptoglobin-hemoglobin receptor (Tb06.28F21.220) |
PBD dimer SG3552 |
Mal-PEG4 |
[83] | |
CDX-0125-TEI |
Anti-ALK mAb DX-0125 |
ALK tyrosine kinase receptor (ALK) |
NMS-P945 |
Undisclosed |
[84] | |
Anti-CLL-1-ds-PBD |
Anti-CLL-1 THIOMAB Anti-ody |
C-type lectin domain family 12 member A (CLEC12A) |
SG2000 |
Undisclosed |
[85] | |
HER2-HC-H-SS-PBD |
Anti-HER2 mAb |
Receptor tyrosine-protein kinase erbB-2 (ERBB2) |
SG2000 |
H-disulfide linker |
[86] | |
HER2-LC-H-SS-PBD |
Anti-HER2 mAb |
Receptor tyrosine-protein kinase erbB-2 (ERBB2) |
SG2000 |
H-disulfide linker |
[86] | |
HER2-HC-Me-SS-PBD |
Anti-HER2 mAb |
Receptor tyrosine-protein kinase erbB-2 (ERBB2) |
SG2000 |
Me-disulfide linker |
[86] | |
HER2-LC-Me-SS-PBD |
Anti-HER2 mAb |
Receptor tyrosine-protein kinase erbB-2 (ERBB2) |
SG2000 |
Me-disulfide linker |
[86] | |
Alpha-CD22-LC-K149C-10 |
Anti-CD22-LC-K149C |
B-cell receptor CD22 (CD22) |
seco-CBI-dimer |
Mc-peptidomimetic based linker 10 |
[87] | |
Alpha-NaPi2b-LC-K149C-10 |
Anti-NaPi2b-LC-K149C |
Sodium-dependent phosphate transport protein 2B (SLC34A2) |
seco-CBI-dimer |
Mc-peptidomimetic based linker 10 |
[87] | |
Alpha-Ly6E-LC-K149C-10 |
Anti-Ly6E-LC-K149C |
Envelope glycoprotein D (Gd) |
seco-CBI-dimer |
Mc-peptidomimetic based linker 10 |
[87] | |
Alpha-gD-LC-K149C-10 |
Anti-gD-LC-K149C |
Lymphocyte antigen 6E (LY6E) |
seco-CBI-dimer |
Mc-peptidomimetic based linker 10 |
[87] | |
Alpha-CD22-LC-K149C-11 |
Anti-CD22-LC-K149C |
B-cell receptor CD22 (CD22) |
seco-CBI-dimer |
Mal-PEG2 |
[87] | |
Alpha-NaPi2b-LC-K149C-11 |
Anti-NaPi2b-LC-K149C |
Sodium-dependent phosphate transport protein 2B (SLC34A2) |
seco-CBI-dimer |
Mal-PEG2 |
[87] | |
Alpha-Ly6E-LC-K149C-11 |
Anti-Ly6E-LC-K149C |
Lymphocyte antigen 6E (LY6E) |
seco-CBI-dimer |
Mal-PEG2 |
[87] | |
Alpha-CD22-LC-V205C-10 |
Anti-CD22-LC-V205C |
B-cell receptor CD22 (CD22) |
seco-CBI-dimer |
Mc-peptidomimetic based linker 10 |
[87] | |
Alpha-CD22-HC-A140C-10 |
Anti-CD22-HC-A140C |
B-cell receptor CD22 (CD22) |
seco-CBI-dimer |
Mc-peptidomimetic based linker 10 |
[87] | |
Alpha-CD22-HC-A140C-11 |
Anti-CD22-HC-A140C |
B-cell receptor CD22 (CD22) |
seco-CBI-dimer |
Mc-PEG2 |
[87] | |
Alpha-CD22-LC-K149C-12 |
Anti-CD22-LC-K149C |
B-cell receptor CD22 (CD22) |
Seco-CBI-dimer 12 |
Mc-peptidomimetic based linker 12 |
[87] | |
Alpha-gD-LC-K149C-12 |
Anti-gD-LC-K149C |
Envelope glycoprotein D (Gd) |
Seco-CBI-dimer 12 |
Mc-peptidomimetic based linker 12 |
[87] | |
HD12-SG3249 |
Anti-MET mAb hD12 |
Hepatocyte growth factor receptor (MET) |
PBD dimer SG3249 |
Mal-PEG8-Val-Ala-PABC |
[88] | |
HD12-SG3259 |
Anti-MET mAb hD12 |
Hepatocyte growth factor receptor (MET) |
PBD dimer SG3259 |
Mal-PEG8-Val-Ala-PABC |
[88] | |
HD12-SG3315 |
Anti-MET mAb hD12 |
Hepatocyte growth factor receptor (MET) |
PBD dimer SG3315 |
Mal-PEG8-Val-Ala-PABC |
[88] | |
HD12-SG3246 |
Anti-MET mAb hD12 |
Hepatocyte growth factor receptor (MET) |
PBD dimer SG3246 |
Mal-PEG8-Val-Ala-PABC |
[88] | |
HD12-SG3227 |
Anti-MET mAb hD12 |
Hepatocyte growth factor receptor (MET) |
PBD dimer SG3227 |
Mal-PEG8-Val-Ala-PABC |
[88] | |
ABBV-322 |
Depatuxizumab S238C |
Epidermal growth factor receptor (EGFR) |
PBD dimer |
Mc-Val-Ala |
[89] | |
FOLR1-ADC 13a |
Anti-FOLR1 mAb |
Folate receptor alpha (FOLR1) |
PBD dimer 13a |
Adipic acid-Val-Ala-PABC |
[90] | |
FOLR1-ADC 13b |
Anti-FOLR1 mAb |
Folate receptor alpha (FOLR1) |
PBD dimer 13b |
Adipic acid-Val-Ala-PABC |
[90] | |
FOLR1-ADC 13c |
Anti-FOLR1 mAb |
Folate receptor alpha (FOLR1) |
PBD dimer 13c |
Adipic acid-Val-Ala-PABC |
[90] | |
EGFR-ADC 13a |
Anti-EGFR mAb |
Epidermal growth factor receptor (EGFR) |
PBD dimer 14a |
Adipic acid-Val-Ala-PABC |
[90] | |
EGFR-ADC 13b |
Anti-EGFR mAb |
Epidermal growth factor receptor (EGFR) |
PBD dimer 14b |
Adipic acid-Val-Ala-PABC |
[90] | |
EGFR-ADC 13c |
Anti-EGFR mAb |
Epidermal growth factor receptor (EGFR) |
PBD dimer 14c |
Adipic acid-Val-Ala-PABC |
[90] | |
FOLR1-ADC 15 |
Anti-FOLR1 mAb |
Folate receptor alpha (FOLR1) |
PBD dimer 13c |
Adipic acid-Val-CIt-PABC |
[90] | |
Anti-BCMA 15B2GL-SG3249 |
Anti-BCMA antibody 15B2GL |
Tumor necrosis factor receptor superfamily member 17 (TNFRSF17) |
SG3199 |
CL2A |
[91] | |
Anti-BCMA 15B2WT-SG3249 |
Anti-BCMA antibody 15B2WT |
Tumor necrosis factor receptor superfamily member 17 (TNFRSF17) |
SG3199 |
CL2A |
[91] | |
Anti-BCMA I09-SG3249 |
Anti-BCMA antibody I09 |
Tumor necrosis factor receptor superfamily member 17 (TNFRSF17) |
SG3199 |
CL2A |
[91] | |
Anti-BCMA L15-SG3249 |
Anti-BCMA antibody L15 |
Tumor necrosis factor receptor superfamily member 17 (TNFRSF17) |
SG3199 |
CL2A |
[91] | |
Anti-BCMA M02-SG3249 |
Anti-BCMA antibody M02 |
Tumor necrosis factor receptor superfamily member 17 (TNFRSF17) |
SG3199 |
CL2A |
[91] | |
Anti-BCMA N22-SG3249 |
Anti-BCMA antibody N22 |
Tumor necrosis factor receptor superfamily member 17 (TNFRSF17) |
SG3199 |
CL2A |
[91] | |
Anti-BCMA P10-SG3249 |
Anti-BCMA antibody P10 |
Tumor necrosis factor receptor superfamily member 17 (TNFRSF17) |
SG3199 |
CL2A |
[91] | |
Anti-BCMA J6M0-SG3249 |
Anti-BCMA antibody J6M0 |
Tumor necrosis factor receptor superfamily member 17 (TNFRSF17) |
SG3199 |
CL2A |
[91] | |
Anti-BCMA R347-SG3249 |
Anti-BCMA antibody R347 |
Tumor necrosis factor receptor superfamily member 17 (TNFRSF17) |
SG3199 |
CL2A |
[91] | |
SYD998 |
Anti-PSMA mAb wt |
Glutamate carboxypeptidase 2 (FOLH1) |
seco-DUBA |
Mal-PEG2-Val-Cit-PABA-Cyclization Spacer |
[92] | |
SYD1091 |
Anti-PSMA mAb wt HC S41C |
Glutamate carboxypeptidase 2 (FOLH1) |
seco-DUBA |
Mal-PEG2-Val-Cit-PABA-Cyclization Spacer |
[92] | |
SYD1035 |
Anti-PSMA mAb wt HC T120C |
Glutamate carboxypeptidase 2 (FOLH1) |
seco-DUBA |
Mal-PEG2-Val-Cit-PABA-Cyclization Spacer |
[92] | |
WO2015177360A1 ADC-HC152 |
Anti-PSMA mAb wt HC E152C |
Glutamate carboxypeptidase 2 (FOLH1) |
seco-DUBA |
Mal-PEG2-Val-Cit-PABA-Cyclization Spacer |
[92] | |
WO2015177360A1 ADC-HC153 |
Anti-PSMA mAb wt HC P153C |
Glutamate carboxypeptidase 2 (FOLH1) |
seco-DUBA |
Mal-PEG2-Val-Cit-PABA-Cyclization Spacer |
[92] | |
WO2015177360A1 ADC-HC236 |
Anti-PSMA mAb wt HC G236C |
Glutamate carboxypeptidase 2 (FOLH1) |
seco-DUBA |
Mal-PEG2-Val-Cit-PABA-Cyclization Spacer |
[92] | |
WO2015177360A1 ADC-HC247 |
Anti-PSMA mAb wt HC P247C |
Glutamate carboxypeptidase 2 (FOLH1) |
seco-DUBA |
Mal-PEG2-Val-Cit-PABA-Cyclization Spacer |
[92] | |
WO2015177360A1 ADC-HC339 |
Anti-PSMA mAb wt HC A339C |
Glutamate carboxypeptidase 2 (FOLH1) |
seco-DUBA |
Mal-PEG2-Val-Cit-PABA-Cyclization Spacer |
[92] | |
WO2015177360A1 ADC-HC375 |
Anti-PSMA mAb wt HC S375C |
Glutamate carboxypeptidase 2 (FOLH1) |
seco-DUBA |
Mal-PEG2-Val-Cit-PABA-Cyclization Spacer |
[92] | |
WO2015177360A1 ADC-HC376 |
Anti-PSMA mAb wt HC D376C |
Glutamate carboxypeptidase 2 (FOLH1) |
seco-DUBA |
Mal-PEG2-Val-Cit-PABA-Cyclization Spacer |
[92] | |
WO2015177360A1 ADC-HC41-120 |
Anti-PSMA mAb wt HC S41C/T120C |
Glutamate carboxypeptidase 2 (FOLH1) |
seco-DUBA |
Mal-PEG2-Val-Cit-PABA-Cyclization Spacer |
[92] | |
WO2015177360A1 ADC-HC41-375 |
Anti-PSMA mAb wt HC S41C/S375C |
Glutamate carboxypeptidase 2 (FOLH1) |
seco-DUBA |
Mal-PEG2-Val-Cit-PABA-Cyclization Spacer |
[92] | |
WO2015177360A1 ADC-LC40 |
Anti-PSMA mAb wt LC V205C |
Glutamate carboxypeptidase 2 (FOLH1) |
seco-DUBA |
Mal-PEG2-Val-Cit-PABA-Cyclization Spacer |
[92] | |
WO2015177360A1 ADC-LC154 |
Anti-PSMA mAb wt LC P40C |
Glutamate carboxypeptidase 2 (FOLH1) |
seco-DUBA |
Mal-PEG2-Val-Cit-PABA-Cyclization Spacer |
[92] | |
WO2015177360A1 ADC-LC165 |
Anti-PSMA mAb wt LC L154C |
Glutamate carboxypeptidase 2 (FOLH1) |
seco-DUBA |
Mal-PEG2-Val-Cit-PABA-Cyclization Spacer |
[92] | |
WO2015177360A1 ADC-LC205 |
Anti-PSMA mAb wt LC E165C |
Glutamate carboxypeptidase 2 (FOLH1) |
seco-DUBA |
Mal-PEG2-Val-Cit-PABA-Cyclization Spacer |
[92] | |
WO2015177360A1 ADC-LC41 |
Anti-PSMA mAb wt LC G41C |
Glutamate carboxypeptidase 2 (FOLH1) |
seco-DUBA |
Mal-PEG2-Val-Cit-PABA-Cyclization Spacer |
[92] | |
WO2015177360A1 ADC-LC157 |
Anti-PSMA mAb wt LC G157C |
Glutamate carboxypeptidase 2 (FOLH1) |
seco-DUBA |
Mal-PEG2-Val-Cit-PABA-Cyclization Spacer |
[92] | |
WO2015177360A1 ADC-H8-wt |
Anti-5T4 mAb H8 wt |
Trophoblast glycoprotein (TPBG) |
seco-DUBA |
Mal-PEG2-Val-Cit-PABA-Cyclization Spacer |
[92] | |
WO2015177360A1 ADC-LC109 |
Anti-PSMA mAb wt LC T109C |
Glutamate carboxypeptidase 2 (FOLH1) |
seco-DUBA |
Mal-PEG2-Val-Cit-PABA-Cyclization Spacer |
[92] | |
WO2015177360A1 ADC-H8-HC40 |
Anti-5T4 mAb H8 S40C |
Trophoblast glycoprotein (TPBG) |
seco-DUBA |
Mal-PEG2-Val-Cit-PABA-Cyclization Spacer |
[92] | |
WO2015177360A1 ADC-H8-HC41 |
Anti-5T4 mAb H8 P41C |
Trophoblast glycoprotein (TPBG) |
seco-DUBA |
Mal-PEG2-Val-Cit-PABA-Cyclization Spacer |
[92] | |
WO2015177360A1 ADC-Natalizumab S375C |
Natalizumab S375C |
Integrin alpha-4 (ITGA4) |
seco-DUBA |
Mal-PEG2-Val-Cit-PABA-Cyclization Spacer |
[92] | |
Trastuzumab-Compound 43 |
Trastuzumab |
Receptor tyrosine-protein kinase erbB-2 (ERBB2) |
PBD dimer |
Trastuzumab-Compound 43 linker |
[93] | |
Pertuzumab-Compound 43 |
Pertuzumab |
Receptor tyrosine-protein kinase erbB-2 (ERBB2) |
PBD dimer |
Pertuzumab-Compound 43 linker |
[93] | |
Rituximab-Compound 43 |
Rituximab |
B-lymphocyte antigen CD20 (MS4A1) |
PBD dimer |
Rituximab-Compound 43 linker |
[93] | |
Alemtuzumab-Compound 43 |
Alemtuzumab |
CAMPATH-1 antigen (CD52) |
PBD dimer |
Alemtuzumab-Compound 43 linker |
[93] | |
Bevacizumab-Compound 43 |
Bevacizumab |
Vascular endothelial growth factor A (VEGFA) |
PBD dimer |
Bevacizumab-Compound 43 linker |
[93] | |
Adalimumab-Compound 43 |
Adalimumab |
Tumor necrosis factor (TNF) |
PBD dimer |
Adalimumab-Compound 43 linker |
[93] | |
Cetuximab-Compound 43 |
Cetuximab |
Epidermal growth factor receptor (EGFR) |
PBD dimer |
Cetuximab-Compound 43 linker |
[93] | |
Amatuximab-Compound 43 |
Amatuximab |
Mesothelin (MSLN) |
PBD dimer |
Amatuximab-Compound 43 linker |
[93] | |
Blinatumomab-Compound 43 |
Blinatumomab |
B-lymphocyte antigen CD19 (CD19); T-cell surface glycoprotein CD3 delta chain (CD3;TPBG) |
PBD dimer |
Blinatumomab-Compound 43 linker |
[93] | |
Brentuximab-Compound 43 |
Brentuximab |
Tumor necrosis factor receptor superfamily member 8 (TNFRSF8) |
PBD dimer |
Brentuximab-Compound 43 linker |
[93] | |
Sacituzumab-Compound 43 |
Sacituzumab |
Tumor-associated calcium signal transducer 2 (TACSTD2) |
PBD dimer |
Sacituzumab-Compound 43 linker |
[93] | |
Panitumumab-Compound 43 |
Panitumumab |
Epidermal growth factor receptor (EGFR) |
PBD dimer |
Panitumumab-Compound 43 linker |
[93] | |
Nimotuzumab-Compound 43 |
Nimotuzumab |
Epidermal growth factor receptor (EGFR) |
PBD dimer |
Nimotuzumab-Compound 43 linker |
[93] | |
Gemtuzumab-Compound 43 |
Gemtuzumab |
Myeloid cell surface antigen CD33 (CD33) |
PBD dimer |
Gemtuzumab-Compound 43 linker |
[93] | |
Golimumab-Compound 43 |
Golimumab |
Tumor necrosis factor (TNF) |
PBD dimer |
Golimumab-Compound 43 linker |
[93] | |
Ibritumomab-Compound 43 |
Ibritumomab |
B-lymphocyte antigen CD20 (MS4A1) |
PBD dimer |
Ibritumomab-Compound 43 linker |
[93] | |
Infliximab-Compound 43 |
Infliximab |
Tumor necrosis factor (TNF) |
PBD dimer |
Infliximab-Compound 43 linker |
[93] | |
Ipilimumab-Compound 43 |
Ipilimumab |
Cytotoxic T-lymphocyte protein 4 (CTLA4) |
PBD dimer |
Ipilimumab-Compound 43 linker |
[93] | |
Ofatumumab-Compound 43 |
Ofatumumab |
B-lymphocyte antigen CD20 (MS4A1) |
PBD dimer |
Ofatumumab-Compound 43 linker |
[93] | |
Tositumomab-Compound 43 |
Tositumomab |
B-lymphocyte antigen CD20 (MS4A1) |
PBD dimer |
Tositumomab-Compound 43 linker |
[93] | |
Trastuzumab-Compound 49 |
Trastuzumab |
Receptor tyrosine-protein kinase erbB-2 (ERBB2) |
PBD dimer |
Trastuzumab-Compound 49 linker |
[93] | |
Pertuzumab-Compound 49 |
Pertuzumab |
Receptor tyrosine-protein kinase erbB-2 (ERBB2) |
PBD dimer |
Pertuzumab-Compound 49 linker |
[93] | |
Rituximab-Compound 49 |
Rituximab |
B-lymphocyte antigen CD20 (MS4A1) |
PBD dimer |
Rituximab-Compound 49 linker |
[93] | |
Alemtuzumab-Compound 49 |
Alemtuzumab |
CAMPATH-1 antigen (CD52) |
PBD dimer |
Alemtuzumab-Compound 49 linker |
[93] | |
Bevacizumab-Compound 49 |
Bevacizumab |
Vascular endothelial growth factor A (VEGFA) |
PBD dimer |
Bevacizumab-Compound 49 linker |
[93] | |
Adalimumab-Compound 49 |
Adalimumab |
Tumor necrosis factor (TNF) |
PBD dimer |
Adalimumab-Compound 49 linker |
[93] | |
Cetuximab-Compound 49 |
Cetuximab |
Epidermal growth factor receptor (EGFR) |
PBD dimer |
Cetuximab-Compound 49 linker |
[93] | |
Amatuximab-Compound 49 |
Amatuximab |
Mesothelin (MSLN) |
PBD dimer |
Amatuximab-Compound 49 linker |
[93] | |
Blinatumomab-Compound 49 |
Blinatumomab |
B-lymphocyte antigen CD19 (CD19); T-cell surface glycoprotein CD3 delta chain (CD3;TPBG) |
PBD dimer |
Blinatumomab-Compound 49 linker |
[93] | |
Brentuximab-Compound 49 |
Brentuximab |
Tumor necrosis factor receptor superfamily member 8 (TNFRSF8) |
PBD dimer |
Brentuximab-Compound 49 linker |
[93] | |
Sacituzumab-Compound 49 |
Sacituzumab |
Tumor-associated calcium signal transducer 2 (TACSTD2) |
PBD dimer |
Sacituzumab-Compound 49 linker |
[93] | |
Panitumumab-Compound 49 |
Panitumumab |
Epidermal growth factor receptor (EGFR) |
PBD dimer |
Panitumumab-Compound 49 linker |
[93] | |
Nimotuzumab-Compound 49 |
Nimotuzumab |
Epidermal growth factor receptor (EGFR) |
PBD dimer |
Nimotuzumab-Compound 49 linker |
[93] | |
Gemtuzumab-Compound 49 |
Gemtuzumab |
Myeloid cell surface antigen CD33 (CD33) |
PBD dimer |
Gemtuzumab-Compound 49 linker |
[93] | |
Golimumab-Compound 49 |
Golimumab |
Tumor necrosis factor (TNF) |
PBD dimer |
Golimumab-Compound 49 linker |
[93] | |
Ibritumomab-Compound 49 |
Ibritumomab |
B-lymphocyte antigen CD20 (MS4A1) |
PBD dimer |
Ibritumomab-Compound 49 linker |
[93] | |
Infliximab-Compound 49 |
Infliximab |
Tumor necrosis factor (TNF) |
PBD dimer |
Infliximab-Compound 49 linker |
[93] | |
Ipilimumab-Compound 49 |
Ipilimumab |
Cytotoxic T-lymphocyte protein 4 (CTLA4) |
PBD dimer |
Ipilimumab-Compound 49 linker |
[93] | |
Ofatumumab-Compound 49 |
Ofatumumab |
B-lymphocyte antigen CD20 (MS4A1) |
PBD dimer |
Ofatumumab-Compound 49 linker |
[93] | |
Tositumomab-Compound 49 |
Tositumomab |
B-lymphocyte antigen CD20 (MS4A1) |
PBD dimer |
Tositumomab-Compound 49 linker |
[93] | |
Trastuzumab-Compound 74 |
Trastuzumab |
Receptor tyrosine-protein kinase erbB-2 (ERBB2) |
PBD dimer |
Trastuzumab-Compound 74 linker |
[93] | |
Pertuzumab-Compound 74 |
Pertuzumab |
Receptor tyrosine-protein kinase erbB-2 (ERBB2) |
PBD dimer |
Pertuzumab-Compound 74 linker |
[93] | |
Rituximab-Compound 74 |
Rituximab |
B-lymphocyte antigen CD20 (MS4A1) |
PBD dimer |
Rituximab-Compound 74 linker |
[93] | |
Alemtuzumab-Compound 74 |
Alemtuzumab |
CAMPATH-1 antigen (CD52) |
PBD dimer |
Alemtuzumab-Compound 74 linker |
[93] | |
Bevacizumab-Compound 74 |
Bevacizumab |
Vascular endothelial growth factor A (VEGFA) |
PBD dimer |
Bevacizumab-Compound 74 linker |
[93] | |
Adalimumab-Compound 74 |
Adalimumab |
Tumor necrosis factor (TNF) |
PBD dimer |
Adalimumab-Compound 74 linker |
[93] | |
Cetuximab-Compound 74 |
Cetuximab |
Epidermal growth factor receptor (EGFR) |
PBD dimer |
Cetuximab-Compound 74 linker |
[93] | |
Amatuximab-Compound 74 |
Amatuximab |
Mesothelin (MSLN) |
PBD dimer |
Amatuximab-Compound 74 linker |
[93] | |
Blinatumomab-Compound 74 |
Blinatumomab |
B-lymphocyte antigen CD19 (CD19); T-cell surface glycoprotein CD3 delta chain (CD3;TPBG) |
PBD dimer |
Blinatumomab-Compound 74 linker |
[93] | |
Brentuximab-Compound 74 |
Brentuximab |
Tumor necrosis factor receptor superfamily member 8 (TNFRSF8) |
PBD dimer |
Brentuximab-Compound 74 linker |
[93] | |
Sacituzumab-Compound 74 |
Sacituzumab |
Tumor-associated calcium signal transducer 2 (TACSTD2) |
PBD dimer |
Sacituzumab-Compound 74 linker |
[93] | |
Panitumumab-Compound 74 |
Panitumumab |
Epidermal growth factor receptor (EGFR) |
PBD dimer |
Panitumumab-Compound 74 linker |
[93] | |
Nimotuzumab-Compound 74 |
Nimotuzumab |
Epidermal growth factor receptor (EGFR) |
PBD dimer |
Nimotuzumab-Compound 74 linker |
[93] | |
Gemtuzumab-Compound 74 |
Gemtuzumab |
Myeloid cell surface antigen CD33 (CD33) |
PBD dimer |
Gemtuzumab-Compound 74 linker |
[93] | |
Golimumab-Compound 74 |
Golimumab |
Tumor necrosis factor (TNF) |
PBD dimer |
Golimumab-Compound 74 linker |
[93] | |
Ibritumomab-Compound 74 |
Ibritumomab |
B-lymphocyte antigen CD20 (MS4A1) |
PBD dimer |
Ibritumomab-Compound 74 linker |
[93] | |
Infliximab-Compound 74 |
Infliximab |
Tumor necrosis factor (TNF) |
PBD dimer |
Infliximab-Compound 74 linker |
[93] | |
Ipilimumab-Compound 74 |
Ipilimumab |
Cytotoxic T-lymphocyte protein 4 (CTLA4) |
PBD dimer |
Ipilimumab-Compound 74 linker |
[93] | |
Ofatumumab-Compound 74 |
Ofatumumab |
B-lymphocyte antigen CD20 (MS4A1) |
PBD dimer |
Ofatumumab-Compound 74 linker |
[93] | |
Tositumomab-Compound 74 |
Tositumomab |
B-lymphocyte antigen CD20 (MS4A1) |
PBD dimer |
Tositumomab-Compound 74 linker |
[93] | |
Anti-MSL1 mAb-Compound 43 |
Anti-MSL1 mAb |
Male-specific lethal 1 homolog (MSL1) |
PBD dimer |
Anti-MSL1 mAb-Compound 43 linker |
[93] | |
Anti-CD59 mAb-Compound 43 |
Anti-CD59 mAb |
CD59 glycoprotein (CD59) |
PBD dimer |
Anti-CD59 mAb-Compound 43 linker |
[93] | |
Anti-HER2 mAb-Compound 43 |
Anti-HER2 mAb |
Receptor tyrosine-protein kinase erbB-2 (ERBB2) |
PBD dimer |
Anti-HER2 mAb-Compound 43 linker |
[93] | |
Anti-MSL1 mAb-Compound 49 |
Anti-MSL1 mAb |
Male-specific lethal 1 homolog (MSL1) |
PBD dimer |
Anti-MSL1 mAb-Compound 49 linker |
[93] | |
Anti-CD59 mAb-Compound 49 |
Anti-CD59 mAb |
CD59 glycoprotein (CD59) |
PBD dimer |
Anti-CD59 mAb-Compound 49 linker |
[93] | |
Anti-HER2 mAb-Compound 49 |
Anti-HER2 mAb |
Receptor tyrosine-protein kinase erbB-2 (ERBB2) |
PBD dimer |
Anti-HER2 mAb-Compound 49 linker |
[93] | |
Anti-MSL1 mAb-Compound 74 |
Anti-MSL1 mAb |
Male-specific lethal 1 homolog (MSL1) |
PBD dimer |
Anti-MSL1 mAb-Compound 74 linker |
[93] | |
Anti-CD59 mAb-Compound 74 |
Anti-CD59 mAb |
CD59 glycoprotein (CD59) |
PBD dimer |
Anti-CD59 mAb-Compound 74 linker |
[93] | |
Anti-HER2 mAb-Compound 74 |
Anti-HER2 mAb |
Receptor tyrosine-protein kinase erbB-2 (ERBB2) |
PBD dimer |
Anti-HER2 mAb-Compound 74 linker |
[93] |
Investigative
| ADC Info | ADC Name | Antibody | Antigen | Payload | Linker | Ref |
|---|---|---|---|---|---|---|
Isotype-SG3249 |
undisclosed |
undisclosed |
SG3199 |
Undisclosed |
[94] | |
Isotype-SG3376 |
undisclosed |
undisclosed |
SG3199 |
Undisclosed |
[94] | |
ADC based on linker 1 (DAR 2) |
undisclosed |
Staphylococcus aureus bacteria |
Mitomycin C |
Undisclosed |
[95] | |
ADC based on linker 1 (DAR 5) |
undisclosed |
Staphylococcus aureus bacteria |
Mitomycin C |
Undisclosed |
[95] | |
ADC based on linker 2 (DAR 2) |
undisclosed |
Staphylococcus aureus bacteria |
Mitomycin C |
Undisclosed |
[95] | |
37290045 ADC based on linker 2 (DAR 5) |
undisclosed |
Staphylococcus aureus bacteria |
Mitomycin C |
Undisclosed |
[95] | |
39757732 ADC2 |
Ab-2 |
Undisclosed |
PBD dimer |
D2 Linker |
[96] | |
CD117-ADC |
undisclosed |
Mast/stem cell growth factor receptor Kit (KIT) |
SG3199 |
Mal-PEG8-Val-Ala-PABC |
[97] | |
39870768 20D9h3-DUBA |
20D9h3 |
Receptor-type tyrosine-protein kinase FLT3 (FLT3) |
seco-DUBA |
Undisclosed |
[98] | |
anti TRBC1-SG3249 |
undisclosed |
T cell receptor beta-chain constant region 1 (TRBC1) |
SG3199 |
CL2A |
[99] | |
Chimeric anti TRBC1-SG3249 |
undisclosed |
T cell receptor beta-chain constant region 1 (TRBC1) |
SG3199 |
CL2A |
[99] | |
KK2845 |
TIM-3Ab |
TIM3 |
SG3199 (SC-DR002) |
Mal-PEG8-Val-Ala-PABC |
[100] | |
KM8047-SG3249 |
KM8047 |
Undisclosed |
SG3199 |
Undisclosed |
[100] | |
CD33-ADC |
h2H12 |
Myeloid cell surface antigen CD33 (CD33) |
SG3199 |
Undisclosed |
[100] | |
QLS5132 |
Anti-CLDN6 antibody |
CLDN6 |
QLS6916 |
A cleavable linker |
[101] | |
AM E3-SG3249 |
AM E3 |
Cytokine receptor-like factor 2 (CRLF2) |
SG3199 |
Mal-PEG8-Val-Ala-PABC |
[102] | |
NZ761939B 15B2GL-SG3249 |
15B2GL |
Tumor necrosis factor receptor superfamily member 17 (TNFRSF17) |
SG3199 |
CL2A |
[103] | |
I09-SG3249 |
I09 |
Tumor necrosis factor receptor superfamily member 17 (TNFRSF17) |
SG3199 |
CL2A |
[103] | |
L15-SG3249 |
L15 |
Tumor necrosis factor receptor superfamily member 17 (TNFRSF17) |
SG3199 |
CL2A |
[103] | |
M02-SG3249 |
M02 |
Tumor necrosis factor receptor superfamily member 17 (TNFRSF17) |
SG3199 |
CL2A |
[103] | |
N22-SG3249 |
N22 |
Tumor necrosis factor receptor superfamily member 17 (TNFRSF17) |
SG3199 |
CL2A |
[103] | |
P10-SG3249 |
P10 |
Tumor necrosis factor receptor superfamily member 17 (TNFRSF17) |
SG3199 |
CL2A |
[103] | |
Trastuzumab-LD1 |
Trastuzumab |
Receptor tyrosine-protein kinase erbB-2 (ERBB2) |
seco-DUBA |
Trastuzumab-LD1-LINKER |
[104] | |
Trastuzumab-LD3 |
Trastuzumab |
Receptor tyrosine-protein kinase erbB-2 (ERBB2) |
seco-DUBA |
Trastuzumab-LD3-LINKER |
[104] | |
Trastuzumab-LD4 |
Trastuzumab |
Receptor tyrosine-protein kinase erbB-2 (ERBB2) |
seco-DUBA |
Trastuzumab-LD1-LINKER |
[104] | |
Trastuzumab-LD5 |
Trastuzumab |
Receptor tyrosine-protein kinase erbB-2 (ERBB2) |
seco-DUBA |
Trastuzumab-LD1-LINKER |
[104] | |
Trastuzumab-LD6 |
Trastuzumab |
Receptor tyrosine-protein kinase erbB-2 (ERBB2) |
seco-DUBA |
Trastuzumab-LD1-LINKER |
[104] | |
PSMA-HC41-LD36 |
Anti-PSMA-HC41 |
Glutamate carboxypeptidase 2 (FOLH1) |
seco-DUBA |
PSMA-HC41-LD36 LINKER |
[104] | |
JP2024177330A5 18G3-CPI |
18G3 |
Interleukin-3 receptor subunit alpha (IL3RA) |
Cyclopropylpyrroloindoline (CPI) payload |
Undisclosed |
[105] | |
JP2024177330A5 16D6-CPI |
16D6 |
Interleukin-3 receptor subunit alpha (IL3RA) |
Cyclopropylpyrroloindoline (CPI) payload |
Undisclosed |
[105] | |
JP2024177330A5 3D1-CPI |
3D1 |
Interleukin-3 receptor subunit alpha (IL3RA) |
Cyclopropylpyrroloindoline (CPI) payload |
Undisclosed |
[105] | |
JP2024177330A5 20D7-CPI |
20D7 |
Interleukin-3 receptor subunit alpha (IL3RA) |
Cyclopropylpyrroloindoline (CPI) payload |
Undisclosed |
[105] | |
ZA202500202A 2188-D04-Y180-LP9 |
2188-D04-Y180 |
Inactive tyrosine-protein kinase transmembrane receptor ROR1 (ROR1) |
PBD dimer |
DBCO-PEG4-VA |
[106] | |
IN202417103159A 2188-D04-Yl80-LP9 |
undisclosed |
Inactive tyrosine-protein kinase transmembrane receptor ROR1 (ROR1) |
PBD |
Undisclosed |
[107] | |
anti-TRBC1-SG3249 |
undisclosed |
T-cell receptor beta constant region (TRBC) |
SG3199 |
CL2A |
[108] | |
Chimeric anti-TRBC1-SG3249 |
undisclosed |
T-cell receptor beta constant region (TRBC) |
SG3199 |
CL2A |
[108] | |
DBCO-vc-seco DUBA |
HuSS1 |
Undisclosed |
seco-DUBA |
EP4161582A4+DBCO-vc-seco DUBA+Linker |
[109] | |
DBCO-DTPA |
HuSS1 |
Undisclosed |
seco-DUBA |
EP4161582A4+DBCO-DTPA+Linker |
[109] | |
HuCL47-B1 |
HuCL47 |
Interleukin-13 receptor subunit alpha-2 (IL13RA2) |
B4 Payload |
US20230285580A1 B12-B2 linker |
[110] | |
US20230285580A1 B12-B1 |
B12 |
Undisclosed |
B4 Payload |
US20230285580A1 B12-B2 linker |
[110] | |
HuCL47-B6 |
HuCL47 |
Interleukin-13 receptor subunit alpha-2 (IL13RA2) |
B4 Payload |
US20230285580A1 B12-B6 linker |
[110] | |
US20230285580A1 B12-B6 |
B12 |
Undisclosed |
B4 Payload |
US20230285580A1 B12-B6 linker |
[110] | |
WO2024181570A1 ADC7 |
Antibody 1 |
Syndecan-1 (SDC1) |
PBD |
Mc-Val-Ala |
[111] | |
CD45-ADC (37567393) |
anti-mouse CD45.2 |
Receptor-type tyrosine-protein phosphatase C (PTPRC) |
SG3199 |
Mal-PEG8-Val-Ala-PABC |
[112] | |
ITC-6146RO |
Anti-B7H3 antibody |
B7-H3 |
Duocarmycin derivative |
Self-immolative OHPAS linker |
References
