Antibody-drug Conjugate Information
General Information of This Antibody-drug Conjugate (ADC)
| ADC ID |
DRG0RVHLX
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| ADC Name |
HYP7-DC
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| Synonyms |
HYP7-DC
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| Drug Status |
Investigative
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| Indication |
In total 1 Indication(s)
Hepatocellular carcinoma [ICD11:2C12]
Investigative
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| Drug-to-Antibody Ratio |
1.7-2.4
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| Structure |
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| Antibody Name |
Humanized GPC3-specific Anti-ody YP7
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Antibody Info | ||||
| Antigen Name |
Glypican-3 (GPC3)
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Antigen Info | ||||
| Payload Name |
Duocarmycin Sa
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Payload Info | ||||
| Therapeutic Target |
Human Deoxyribonucleic acid (hDNA)
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Target Info | ||||
| Linker Name |
Mal-PEG4-Val-Cit-PABC-DMAE
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Linker Info | ||||
| Conjugate Type |
Unspecific conjugation between maleimide on the payload and thiol groups on the hYP7 generated from the reduction of interstrand disulfide bonds.
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