Antibody-drug Conjugate Information

General Information of This Antibody-drug Conjugate (ADC)
ADC ID
DRG0UFDDX
ADC Name
chDAB4-SG3249
Synonyms
chDAB4 SG3249
   Click to Show/Hide
Drug Status
Investigative
Indication
In total 1 Indication(s)
Lung cancer [ICD11:2C25]
Investigative
Drug-to-Antibody Ratio
1.9
Antibody Name
Chimeric DAB4 (chDAB4)
  Antibody Info 
Antigen Name
Lupus La protein (SSB)
  Antigen Info 
Payload Name
SG3199
  Payload Info 
Therapeutic Target
Human Deoxyribonucleic acid (hDNA)
  Target Info 
Linker Name
Mal-PEG8-Val-Ala-PABC
  Linker Info 
Conjugate Type
Random conjugation through reduced inter-chain cysteines.
Combination Type
SG3249
General Information of The Activity Data Related to This ADC
Discovered Using Cell Line-derived Xenograft Model
Click To Hide/Show 1 Activity Data Related to This Level
Standard Type Value Units Cell Line Disease Model
Tumor Growth Inhibition value (TGI) 
≈ 96.5
%
LL2 cells
Normal
Full List of Activity Data of This Antibody-drug Conjugate
Discovered Using Cell Line-derived Xenograft Model
Click To Hide/Show 1 Activity Data Related to This Level
Experiment 1 Reporting the Activity Date of This ADC [1]
Efficacy Data Tumor Growth Inhibition value (TGI) ≈ 96.50% (Day 14) Positive La/SSB expression (La/SSB +++/++)
Method Description
ChDAB4-SG3249 (3 mg/kg, the day after chemotherapy (Day 3)) induces efficient tumor cell killing in cell line-derived models of Lewis lung carcinoma cell with HER3 expression with high expression.
In Vivo Model LL2 CDX model
In Vitro Model Normal LL2 cells CVCL_C4MM
References
Ref 1 Tumour-associated macrophages process drug and radio-conjugates of the dead tumour cell-targeting APOMAB antibody. J Control Release. 2020 Nov 10;327:779-787. doi: 10.1016/j.jconrel.2020.09.027.

If you find any error in data or bug in web service, please kindly report it to Dr. Shen et al.