Antibody-drug Conjugate Information

General Information of This Antibody-drug Conjugate (ADC)
ADC ID
DRG0FPTUU
ADC Name
Tb085-SG3376
Synonyms
Tb085 SG3376
   Click to Show/Hide
Drug Status
Investigative
Indication
In total 1 Indication(s)
African trypanosomiasis [ICD11:1F51]
Investigative
Drug-to-Antibody Ratio
2
Antibody Name
Anti-HpHbR mAb Tb085
  Antibody Info 
Antigen Name
Haptoglobin-hemoglobin receptor (Tb06.28F21.220)
  Antigen Info 
Payload Name
PBD dimer SG3552
  Payload Info 
Therapeutic Target
Human Deoxyribonucleic acid (hDNA)
  Target Info 
Linker Name
Mal-PEG4
  Linker Info 
Conjugate Type
Random conjugation through reduced inter-chain cysteines.
Combination Type
SG3376
General Information of The Activity Data Related to This ADC
Revealed Based on the Cell Line Data
Click To Hide/Show 1 Activity Data Related to This Level
Standard Type Value Units Cell Line Disease Model
Half Maximal Inhibitory Concentration (IC50) 
9
pM
T. brucei gambiense (T. b. brucei)
Undisclosed
Full List of Activity Data of This Antibody-drug Conjugate
Revealed Based on the Cell Line Data
Click To Hide/Show 1 Activity Data Related to This Level
Experiment 1 Reporting the Activity Date of This ADC [1]
Efficacy Data Half Maximal Inhibitory Concentration (IC50)
9.00 pM
Method Description
On day 3, groups of five mice were then treated with (1) 0.25 mg/kg Tb085-SG3376 or (2) 0.25 mg/kg NIP228-SG3376 or (3) PBS alone. Three uninfected mice were used as negative controls for the BLI.
In Vitro Model . T. brucei gambiense (T. b. brucei) .
References
Ref 1 A single dose of antibody-drug conjugate cures a stage 1 model of African trypanosomiasis. PLoS Negl Trop Dis. 2019 May 23;13(5):e0007373. doi: 10.1371/journal.pntd.0007373. eCollection 2019 May.

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