Antibody-drug Conjugate Information
General Information of This Antibody-drug Conjugate (ADC)
| ADC ID |
DRG0WRABL
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| ADC Name |
Anti-IL13RA2 PBD ADC
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| Synonyms |
Anti-IL13RA2-PBD-ADC
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| Drug Status |
Investigative
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| Indication |
In total 1 Indication(s)
Diffuse intrinsic pontine glioma [ICD11:XH61Y5]
Investigative
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| Drug-to-Antibody Ratio |
3-4
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| Structure |
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| Antibody Name |
Anti-IL13RA2 mAb 2E10
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Antibody Info | ||||
| Antigen Name |
Interleukin-13 receptor subunit alpha-2 (IL13RA2)
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Antigen Info | ||||
| Payload Name |
SGD-1882
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Payload Info | ||||
| Therapeutic Target |
Human Deoxyribonucleic acid (hDNA)
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Target Info | ||||
| Linker Name |
Mc-Val-Ala
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Linker Info | ||||
| Conjugate Type |
The conjugation was a maleimide-cysteine based method by first reducing the antibody inter-chain disulfide bond and then linking the maleimide moiety of the drug to the reduced cysteines to generate the ADC.
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| Combination Type |
SGD-1910
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