Antibody-drug Conjugate Information
General Information of This Antibody-drug Conjugate (ADC)
| ADC ID |
DRG0QQSKK
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| ADC Name |
CD33-CPI dimer ADC
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| Synonyms |
CD33-CPI dimer-ADC
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| Drug Status |
Investigative
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| Indication |
In total 1 Indication(s)
Acute myeloid leukaemia [ICD11:2A60]
Investigative
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| Drug-to-Antibody Ratio |
2
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| Structure |
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| Antibody Name |
Anti-CD33 Anti-ody 11A1
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Antibody Info | ||||
| Antigen Name |
Myeloid cell surface antigen CD33 (CD33)
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Antigen Info | ||||
| Payload Name |
Bicyclopentyl-seco-CBI-dimer
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Payload Info | ||||
| Therapeutic Target |
Human Deoxyribonucleic acid (hDNA)
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Target Info | ||||
| Linker Name |
AcLys-Val-Cit-PABC-DMAE
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Linker Info | ||||
| Conjugate Type |
Linker-payload is attached to an engineered Y296Q residue in the antibody heavy chain via transglutaminase-mediated conjugation.
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