Antibody-drug Conjugate Information
General Information of This Antibody-drug Conjugate (ADC)
| ADC ID |
DRG0IYJMP
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| ADC Name |
HuC242-SMCC-DC4
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| Synonyms |
HuC242 SMCC DC4
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| Drug Status |
Investigative
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| Indication |
In total 2 Indication(s)
Colon cancer [ICD11:2B90]
Investigative
Melanoma [ICD11:2C30]
Investigative
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| Drug-to-Antibody Ratio |
3.5-5
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| Structure |
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| Antibody Name |
Cantuzumab
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Antibody Info | ||||
| Antigen Name |
Syndecan-1 (SDC1)
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Antigen Info | ||||
| Payload Name |
Phosphate prodrugs 40 (DC4)
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Payload Info | ||||
| Therapeutic Target |
Human Deoxyribonucleic acid (hDNA)
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Target Info | ||||
| Linker Name |
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
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Linker Info | ||||
| Conjugate Type |
Lysine residue on the antibody is conjugated via an amide bond to the linker-payload moiety.
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| Combination Type |
SMCC-DC4
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