Antibody-drug Conjugate Information
General Information of This Antibody-drug Conjugate (ADC)
| ADC ID |
DRG0CXLYV
|
|||||
|---|---|---|---|---|---|---|
| ADC Name |
HuC242-SPDB-DC4
|
|||||
| Synonyms |
HuC242 SPDB DC4
Click to Show/Hide
|
|||||
| Drug Status |
Investigative
|
|||||
| Indication |
In total 2 Indication(s)
Acute promyelocytic leukemia [ICD11:2A60]
Investigative
Burkitt lymphoma [ICD11:2A85]
Investigative
|
|||||
| Drug-to-Antibody Ratio |
3.5-5
|
|||||
| Structure |
|
|||||
| Antibody Name |
Cantuzumab
|
Antibody Info | ||||
| Antigen Name |
Syndecan-1 (SDC1)
|
Antigen Info | ||||
| Payload Name |
Phosphate prodrugs 40 (DC4)
|
Payload Info | ||||
| Therapeutic Target |
Human Deoxyribonucleic acid (hDNA)
|
Target Info | ||||
| Linker Name |
N-succinimidyl 4-(2-pyridyldithio) butanoate (SPDB)
|
Linker Info | ||||
| Conjugate Type |
Lysine residue on the antibody is conjugated via an amide bond to the linker-payload moiety.
|
|||||
| Combination Type |
SPDB-DC4
|
|||||
If you find any error in data or bug in web service, please kindly report it to Dr. Shen et al.