Antibody-drug Conjugate Information
General Information of This Antibody-drug Conjugate (ADC)
| ADC ID |
DRG0YZPWM
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| ADC Name |
SGN-CD352A
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| Synonyms |
SGN-CD352A
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| Organization |
Seagen (Top20 MNC) (Originator)
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| Drug Status |
Phase 1 (discontinued)
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| Drug-to-Antibody Ratio |
2
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| Antibody Name |
H20F3ec
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Antibody Info | ||||
| Antigen Name |
SLAM family member 6 (SLAMF6)
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Antigen Info | ||||
| Payload Name |
PBD dimer
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Payload Info | ||||
| Therapeutic Target |
Human deoxyribonucleic acid (hDNA)
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Target Info | ||||
| Linker Name |
Val-Ala dipeptide linker
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Linker Info | ||||
| Conjugate Type |
Reactive Cysteines
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The indication landscape of This ADC(2027 Update)
The clinical trial pipeline of This ADC(2027 Update)
| Indication | Phase 1 | Phase 1/2 | Phase 2 | Phase 2/3 | Phase 3 | New Drug Application | Approved | ||
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| Multiple myeloma |
1 Trials
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General Information of The Activity Data Related to This ADC
Full List of Activity Data of This Antibody-drug Conjugate
Identified from the Human Clinical Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Patients Enrolled |
Eligible participants must have IMWG-defined multiple myeloma requiring systemic therapy, age ≥18 years, ECOG 0-1, life expectancy >3 months, ≥2 prior lines of therapy (including IMiD and PI), measurable disease, adequate organ function, and negative pregnancy test. Key exclusions include recent malignancies (past 3 years), active CNS disease, severe infections, HIV/HBV/HCV positivity, prior allogeneic transplant, significant pulmonary/cardiovascular comorbidities, or pregnancy/breastfeeding.
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| Administration Dosage |
On the first day of each 28-day cycle, SGN-CD352A will be given IV. The dose of SGN-CD352A is different in each cohort of the study, with the lowest dose in Cohort -1 (4 mcg/kg) and the highest in Cohort 6 (65 mcg/kg). Patients can only be enrolled into a higher dose level arm if lower doses have proven safe.
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| Related Clinical Trial | |||||
| NCT Number | NCT02954796 | Clinical Status | PHASE1 | ||
| Clinical Description | Phase 1 Study of SGN-CD352A in Patients With Relapsed or Refractory Multiple Myeloma | ||||
| Primary Endpoint |
The study assesses safety through comprehensive evaluation of adverse events (type, incidence, severity, seriousness, and relatedness) monitored for 1 month post-treatment, along with dose-limiting toxicities during the first 28-day cycle.
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| Other Endpoint |
Efficacy outcomes include overall survival, progression-free survival, duration of response (both objective and complete), and response rates (ORR/CR) tracked for approximately 3 years, complemented by immunogenicity analysis (antitherapeutic antibodies) and pharmacokinetic profiling of SGN-CD352A and metabolites over the same period.
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References