Antigen Information
General Information of This Antigen
| Antigen ID | TAR0THKZD |
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|---|---|---|---|---|---|---|
| Antigen Name | Receptor tyrosine-protein kinase erbB-2 (ERBB2) |
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| Gene Name | ERBB2 |
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| Gene ID | ||||||
| Synonym | HER2; MLN19; NEU; NGL; Metastatic lymph node gene 19 protein;Proto-oncogene Neu;Proto-oncogene c-ErbB-2;Tyrosine kinase-type cell surface receptor HER2;p185erbB2;CD_antigen=CD340 |
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| Sequence |
MELAALCRWGLLLALLPPGAASTQVCTGTDMKLRLPASPETHLDMLRHLYQGCQVVQGNL
ELTYLPTNASLSFLQDIQEVQGYVLIAHNQVRQVPLQRLRIVRGTQLFEDNYALAVLDNG DPLNNTTPVTGASPGGLRELQLRSLTEILKGGVLIQRNPQLCYQDTILWKDIFHKNNQLA LTLIDTNRSRACHPCSPMCKGSRCWGESSEDCQSLTRTVCAGGCARCKGPLPTDCCHEQC AAGCTGPKHSDCLACLHFNHSGICELHCPALVTYNTDTFESMPNPEGRYTFGASCVTACP YNYLSTDVGSCTLVCPLHNQEVTAEDGTQRCEKCSKPCARVCYGLGMEHLREVRAVTSAN IQEFAGCKKIFGSLAFLPESFDGDPASNTAPLQPEQLQVFETLEEITGYLYISAWPDSLP DLSVFQNLQVIRGRILHNGAYSLTLQGLGISWLGLRSLRELGSGLALIHHNTHLCFVHTV PWDQLFRNPHQALLHTANRPEDECVGEGLACHQLCARGHCWGPGPTQCVNCSQFLRGQEC VEECRVLQGLPREYVNARHCLPCHPECQPQNGSVTCFGPEADQCVACAHYKDPPFCVARC PSGVKPDLSYMPIWKFPDEEGACQPCPINCTHSCVDLDDKGCPAEQRASPLTSIISAVVG ILLVVVLGVVFGILIKRRQQKIRKYTMRRLLQETELVEPLTPSGAMPNQAQMRILKETEL RKVKVLGSGAFGTVYKGIWIPDGENVKIPVAIKVLRENTSPKANKEILDEAYVMAGVGSP YVSRLLGICLTSTVQLVTQLMPYGCLLDHVRENRGRLGSQDLLNWCMQIAKGMSYLEDVR LVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETEYHADGGKVPIKWMALESILRRRFT HQSDVWSYGVTVWELMTFGAKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMIMVKCWM IDSECRPRFRELVSEFSRMARDPQRFVVIQNEDLGPASPLDSTFYRSLLEDDDMGDLVDA EEYLVPQQGFFCPDPAPGAGGMVHHRHRSSSTRSGGGDLTLGLEPSEEEAPRSPLAPSEG AGSDVFDGDLGMGAAKGLQSLPTHDPSPLQRYSEDPTVPLPSETDGYVAPLTCSPQPEYV NQPDVRPQPPSPREGPLPAARPAGATLERPKTLSPGKNGVVKDVFAFGGAVENPEYLTPQ GGAAPQPHPPPAFSPAFDNLYYWDQDPPERGAPPSTFKGTPTAENPEYLGLDVPV Click to Show/Hide
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| Family | Tyr protein family |
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| Function |
Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and CLASP2, allowing its association with the cell membrane. In turn, membrane-bound APC allows the localization of MACF1 to the cell membrane, which is required for microtubule capture and stabilization.
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| Uniprot Entry | ||||||
| HGNC ID | ||||||
| KEGG ID | ||||||
Each Antibody-drug Conjuate AND It's Component Related to This Antigen
Full List of The ADC Related to This Antigen
1015a
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
WO2024105205A1 11e-1015a |
KSPI6-1 |
Undisclosed |
Undisclosed |
[1] |
2Rs15d
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
39860260 2Rs15d-H3KH6-MMAE |
Monomethyl auristatin E |
Microtubule (MT) |
DBCO-PEG4-Val-Cit-PABC |
[2] |
4D5 HC A118C
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
CN106714844B ADC-101 |
PNU-159682 |
DNA topoisomerase 2-alpha (TOP2A) |
CN106714844B-ADC-101-linker |
[3] | |
CN106714844B ADC-103 |
PNU-159682 |
DNA topoisomerase 2-alpha (TOP2A) |
CN106714844B-ADC-103-linker |
[3] | |
CN106714844B ADC-111 |
PNU-159682 |
DNA topoisomerase 2-alpha (TOP2A) |
Undisclosed |
[3] | |
CN106714844B ADC-112 |
PNU-159682 |
DNA topoisomerase 2-alpha (TOP2A) |
Undisclosed |
[3] | |
CN106714844B ADC-119 |
PNU-159682 |
DNA topoisomerase 2-alpha (TOP2A) |
CN106714844B-ADC-119-linker |
[3] | |
CN106714844B ADC-131 |
PNU-159682 |
DNA topoisomerase 2-alpha (TOP2A) |
Undisclosed |
[3] |
4D5 HC A140C
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
CN106714844B ADC-128 |
PNU-159682 |
DNA topoisomerase 2-alpha (TOP2A) |
Undisclosed |
[3] |
4D5 LC A149C
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
CN106714844B ADC-129 |
PNU-159682 |
DNA topoisomerase 2-alpha (TOP2A) |
Undisclosed |
[3] |
4D5 LC S121C
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
CN106714844B ADC-132 |
PNU-159682 |
DNA topoisomerase 2-alpha (TOP2A) |
Undisclosed |
[3] |
4D5 LC V205C
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
CN106714844B ADC-130 |
PNU-159682 |
DNA topoisomerase 2-alpha (TOP2A) |
Undisclosed |
[3] |
7.16.4_msIgG2a
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
EP4489789A1 7.16.4_msIgG2a Conjugate 4 |
Undisclosed |
Undisclosed |
Undisclosed |
[4] |
7C2 HC A118C
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
CN106714844B ADC-107 |
PNU-159682 |
DNA topoisomerase 2-alpha (TOP2A) |
Undisclosed |
[3] | |
CN106714844B ADC-114 |
PNU-159682 |
DNA topoisomerase 2-alpha (TOP2A) |
Undisclosed |
[3] |
7C2 HC K118C
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
CN106714844B ADC-140 |
PNU-159682 |
DNA topoisomerase 2-alpha (TOP2A) |
Ethylmaleimide linker |
[3] |
7C2 LC K149C
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
CN106714844B ADC-108 |
PNU-159682 |
DNA topoisomerase 2-alpha (TOP2A) |
Undisclosed |
[3] | |
CN106714844B ADC-109 |
PNU-159682 |
DNA topoisomerase 2-alpha (TOP2A) |
CN106714844B-ADC-109-linker |
[3] | |
CN106714844B ADC-116 |
PNU-159682 |
DNA topoisomerase 2-alpha (TOP2A) |
Undisclosed |
[3] | |
CN106714844B ADC-134 |
PNU-159682 |
DNA topoisomerase 2-alpha (TOP2A) |
CN106714844B-ADC-134-linker |
[3] | |
CN106714844B ADC-135 |
PNU-159682 |
DNA topoisomerase 2-alpha (TOP2A) |
CN106714844B-ADC-135-linker |
[3] | |
CN106714844B ADC-136 |
PNU-159682 |
DNA topoisomerase 2-alpha (TOP2A) |
Undisclosed |
[3] | |
CN106714844B ADC-137 |
PNU-159682 |
DNA topoisomerase 2-alpha (TOP2A) |
Ethylmaleimide linker |
[3] | |
CN106714844B ADC-138 |
PNU-159682 |
DNA topoisomerase 2-alpha (TOP2A) |
Ethylmaleimide linker |
[3] |
Ab0001-LCCTL-HC
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
LC301-1-1 (2) |
Dxd-1 |
Undisclosed |
LA301-1-1 linker |
[5] | |
LC301-1-1 (4) |
Dxd-1 |
Undisclosed |
LA301-1-1 linker |
[5] | |
LC301-2-1 (2) |
Dxd-1 |
Undisclosed |
LA301-1-1 linker |
[5] | |
LC301-2-1 (4) |
Dxd-1 |
Undisclosed |
LA301-1-1 linker |
[5] | |
LC301-3-1 (4) |
Dxd-1 |
Undisclosed |
LA301-3-1 linker |
[5] | |
LC301-4-1 (6) |
Dxd-1 |
Undisclosed |
LA301-4-1 linker |
[5] | |
LC301-5-1 (8) |
Dxd-1 |
Undisclosed |
LA301-5-1 linker |
[5] | |
LC302-1-1 (2) |
Dxd-1 |
Undisclosed |
LA302-1-1 linker |
[5] | |
LC302-1-1 (4) |
Dxd-1 |
Undisclosed |
LA302-1-1 linker |
[5] | |
LC302-1-4 (2) |
Dxd-1 |
Undisclosed |
LA302-1-4 linker |
[5] | |
LC302-1-4 (4) |
Dxd-1 |
Undisclosed |
LA302-1-4 linker |
[5] | |
LC302-2-1 (4) |
Dxd-1 |
Undisclosed |
LA302-2-1 linker |
[5] | |
LC302-2-4 (4) 4 |
Dxd-1 |
Undisclosed |
LA302-2-4 linker |
[5] | |
LC302-3-1 (6) |
Dxd-1 |
Undisclosed |
LA302-3-1 linker |
[5] | |
LC302-3-4 (6) |
Dxd-1 |
Undisclosed |
LA302-3-4 linker |
[5] | |
LC302-4-1 (8) |
Dxd-1 |
Undisclosed |
LA302-3-1 linker |
[5] | |
LC302-4-4 (8) |
Dxd-1 |
Undisclosed |
LA302-3-4 linker |
[5] |
ADAPT6-ABD
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
ADAPT6-ABD-mcDM1 |
Mertansine DM1 |
Microtubule (MT) |
Maleimidocaproyl (Ser3-Gly)3 |
[6] |
Anbenitamab
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
Anbenitamab-ADC-Tb3-1 |
Anbenitamab-ADC-Tb3-1 payload |
Undisclosed |
Anbenitamab-ADC-Tb3-1 linker |
[7] | |
Anbenitamab-ADC-Tb3-2 |
Anbenitamab-ADC-Tb3-2 payload |
Undisclosed |
Anbenitamab-ADC-Tb3-2 linker |
[7] | |
Anbenitamab-ADC-Tb3-3 |
Anbenitamab-ADC-Tb3-3 payload |
Undisclosed |
Anbenitamab-ADC-Tb3-3 linker |
[7] | |
Anbenitamab-ADC-Tb3-4 |
Anbenitamab-ADC-Tb3-4 payload |
Undisclosed |
Anbenitamab-ADC-Tb3-4 linker |
[7] | |
Anbenitamab-ADC-Tb3-5 |
Anbenitamab-ADC-Tb3-5 payload |
Undisclosed |
Anbenitamab-ADC-Tb3-5 linker |
[7] | |
Anbenitamab-ADC-Tb3-6 |
Anbenitamab-ADC-Tb3-6 payload |
Undisclosed |
Anbenitamab-ADC-Tb3-6 linker |
[7] | |
Anbenitamab-ADC-Tb3-7 |
Anbenitamab-ADC-Tb3-7 payload |
Undisclosed |
Anbenitamab-ADC-Tb3-7 linker |
[7] | |
Anbenitamab-ADC-Tb3-8 |
Anbenitamab-ADC-Tb3-8 payload |
Undisclosed |
Anbenitamab-ADC-Tb3-8 linker |
[7] | |
Anbenitamab-ADC-Tb3-9 |
Anbenitamab-ADC-Tb3-9 payload |
Undisclosed |
Anbenitamab-ADC-Tb3-9 linker |
[7] | |
Anbenitamab-ADC-Tb3-10 |
Anbenitamab-ADC-Tb3-10 payload |
Undisclosed |
Anbenitamab-ADC-Tb3-10 linker |
[7] |
ANG4043
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
An2-anti-HER2-Doxetaxel |
Docetaxel |
Microtubule (MT) |
Undisclosed |
[8] |
Anti-HER2 1-alpha-hydroxyvitamin-D5-HER-2 Anti-ody conjugate mAb
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
Alpha-hydroxyvitamin-D5-HER2 antibody conjugate |
Vitamin D |
Undisclosed |
Sulfosuccinimidyl 6-4 azido nitrophenylamido hexanode (SANPAH) |
[9] |
anti-Her2 114 (H- (A114C)) and 183 (H- (kK183C)) mAb
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
H- (C)-#10 |
Undisclosed |
Undisclosed |
Undisclosed |
[10] | |
CD33-11A1-v1417 (C)-#39 |
CD33-11A1-v1417 (C)-#39 Payload |
Undisclosed |
CD33-11A1-v1417 (C)-#39 Linker |
[10] |
Anti-HER2 7C2 mAb
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
HER2-5 ADC |
GNE-987 (R) |
Bromodomain-containing protein 4 (BRD4) |
Dolaflexin polymer |
[11] |
Anti-HER2 antibody 20507
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
WO2015095301A2 ADC-28 |
WO2015095301A2 ADC-28 payload |
Undisclosed |
WO2015095301A2 ADC-28 linker |
[12] | |
WO2015095301A2 ADC-29 |
WO2015095301A2 ADC-29 payload |
Undisclosed |
WO2015095301A2 ADC-29 linker |
[12] | |
WO2015095301A2 ADC-30 |
WO2015095301A2 ADC-30 payload |
Undisclosed |
WO2015095301A2 ADC-30 linker |
[12] | |
WO2015095301A2 ADC-31 |
WO2015095301A2 ADC-31 payload |
Undisclosed |
WO2015095301A2 ADC-31 linker |
[12] | |
WO2015095301A2 ADC-32 |
WO2015095301A2 ADC-32 payload |
Undisclosed |
WO2015095301A2 ADC-32 linker |
[12] | |
WO2015095301A2 ADC-33 |
WO2015095301A2 ADC-33 payload |
Undisclosed |
WO2015095301A2 ADC-33 linker |
[12] | |
WO2015095301A2 ADC-34 |
WO2015095301A2 ADC-34 payload |
Undisclosed |
WO2015095301A2 ADC-34 linker |
[12] | |
WO2015095301A2 ADC-35 |
WO2015095301A2 ADC-35 payload |
Undisclosed |
WO2015095301A2 ADC-35 linker |
[12] | |
WO2015095301A2 ADC-36 |
WO2015095301A2 ADC-36 payload |
Undisclosed |
WO2015095301A2 ADC-36 linker |
[12] | |
WO2015095301A2 ADC-37 |
WO2015095301A2 ADC-37 payload |
Undisclosed |
WO2015095301A2 ADC-37 linker |
[12] | |
WO2015189791A1 ADC-27 |
WO2015189791A1 ADC-27 payload |
Undisclosed |
WO2015189791A1 ADC-27 linker |
[13] | |
WO2015189791A1 ADC-28 |
WO2015189791A1 ADC-28 payload |
Undisclosed |
WO2015189791A1 ADC-28 linker |
[13] | |
WO2015189791A1 ADC-29 |
WO2015189791A1 ADC-29 payload |
Undisclosed |
WO2015189791A1 ADC-29 linker |
[13] | |
WO2015189791A1 ADC-30 |
WO2015189791A1 ADC-30 payload |
Undisclosed |
WO2015189791A1 ADC-30 linker |
[13] | |
WO2015189791A1 ADC-31 |
WO2015189791A1 ADC-31 payload |
Undisclosed |
WO2015189791A1 ADC-31 linker |
[13] | |
WO2015189791A1 ADC-32 |
WO2015189791A1 ADC-32 payload |
Undisclosed |
WO2015189791A1 ADC-32 linker |
[13] | |
WO2015189791A1 ADC-33 |
WO2015189791A1 ADC-33 payload |
Undisclosed |
WO2015189791A1 ADC-33 linker |
[13] | |
WO2015189791A1 ADC-34 |
WO2015189791A1 ADC-34 payload |
Undisclosed |
WO2015189791A1 ADC-34 linker |
[13] | |
WO2015189791A1 ADC-35 |
WO2015189791A1 ADC-35 payload |
Undisclosed |
WO2015189791A1 ADC-35 linker |
[13] | |
WO2015189791A1 ADC-36 |
WO2015189791A1 ADC-36 payload |
Undisclosed |
WO2015189791A1 ADC-36 linker |
[13] | |
WO2015189791A1 ADC-37 |
WO2015189791A1 ADC-37 payload |
Undisclosed |
WO2015189791A1 ADC-37 linker |
[13] | |
WO2015189791A1 ADC-40 |
WO2015189791A1 ADC-40 payload |
Undisclosed |
WO2015189791A1 ADC-40 linker |
[13] | |
WO2015189791A1 ADC-61 |
WO2015189791A1 ADC-61 payload |
Undisclosed |
WO2015189791A1 ADC-61 linker |
[13] | |
WO2015189791A1 ADC-63 |
WO2015189791A1 ADC-63 payload |
Undisclosed |
WO2015189791A1 ADC-63 linker |
[13] | |
WO2015189791A1 ADC-64 |
WO2015189791A1 ADC-64 payload |
Undisclosed |
WO2015189791A1 ADC-64 linker |
[13] |
Anti-HER2 antibody 2H9-A121C
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
2H9-A121C-BMPEO-DM1 |
Maytansinoid DM1 |
Microtubule (MT) |
2H9-A121C-BMPEO-DM1 linker |
[14] |
anti-HER2 antibody mAb-1
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
WO2023232144A1ADC-1 |
WO2023232144A1, ADC-1, Payload |
Microtubule (MT) |
WO2023232144A1, ADC-1, linker |
[15] | |
WO2023232144A1ADC-2 |
WO2023232144A1, ADC-2, Payload |
DNA topoisomerase I (TOP1) |
WO2023232144A1, ADC-2, linker |
[15] |
Anti-HER2 DVD-Fab
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
Anti-HER2 DVD-Fab_MMAF |
Monomethyl auristatin F |
Microtubule (MT) |
Dibromomaleimide-PEG4 |
[16] |
Anti-HER2 DVD-Fab-h38c2-K99C
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
Anti-HER2 DVD-Fab-h38c2-K99C_MMAF |
Monomethyl auristatin F |
Microtubule (MT) |
Dibromomaleimide-PEG4 |
[16] |
Anti-HER2 DVD-IgG1
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
Anti-HER2 DVD-IgG1_MMAF |
Monomethyl auristatin F |
Microtubule (MT) |
Dibromomaleimide-PEG4 |
[16] | |
Anti-HER2 DVD-IgG1-Tiancimycin |
Tiancimycin |
Microtubule (MT) |
DVD-PEG4-Triazol |
[17] |
Anti-HER2 DVD-IgG1-H38c2-K99C
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
Anti-HER2 DVD-IgG1-h38c2-K99C_MMAF |
Monomethyl auristatin F |
Microtubule (MT) |
Dibromomaleimide-PEG4 |
[16] | |
Anti-HER2 DVD-IgG1-h38c2-K99C Fluorescein |
Fluorescein derivative |
Undisclosed |
MS-PODA |
[16] | |
Anti-HER2 DVD-IgG1-h38c2-K99C TAMTA 3 |
5(6)-Carboxytetramethylrhodamine |
Undisclosed |
Dibromomaleimide-PEG3 |
[16] | |
Anti-HER2 DVD-IgG1-h38c2-K99C TAMTA 2 |
5(6)-Carboxytetramethylrhodamine |
Undisclosed |
Monobromomaleimide-PEG3 |
[16] | |
Anti-HER2 DVD-IgG1-h38c2-K99C TAMTA 1 |
5(6)-Carboxytetramethylrhodamine |
Undisclosed |
Mal-PEG3 |
[16] |
Anti-HER2 Fab
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
Fab-SN38 |
Active metabolite of irinotecan SN38 |
DNA topoisomerase 1 (TOP1) |
LPETGGG-PEG3-Azide BCN-AVC |
[18] |
Anti-HER2 IgG1(GH2-20)
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
IgG1 (GH2-20)-vc-MMAE |
Monomethyl auristatin E |
Microtubule (MT) |
Mc-Val-Cit-PABC |
[19] |
Anti-HER2 IgG1(GH2-20) scFv
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
ScFv(GH2-20)-PE38KDEL |
Pseudomonas exotoxin PE38 |
Eukaryotic elongation factor 2 kinase (EEF2K) |
Undisclosed |
[19] |
Anti-HER2 IgG1(GH2-20)-AL1
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
IgG1 (GH2-20)-AL1-MMAE |
Monomethyl auristatin E |
Microtubule (MT) |
Undisclosed |
[19] |
Anti-HER2 IgG1(GH2-61)
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
IgG1 (GH2-61)-vc-MMAE |
Monomethyl auristatin E |
Microtubule (MT) |
Mc-Val-Cit-PABC |
[19] |
Anti-HER2 IgG1(GH2-61) scFv
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
ScFv(GH2-61)-PE38KDEL |
Pseudomonas exotoxin PE38 |
Eukaryotic elongation factor 2 kinase (EEF2K) |
Undisclosed |
[19] |
Anti-HER2 IgG1(GH2-61)-AL1
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
IgG1 (GH2-61)-AL1-MMAE |
Monomethyl auristatin E |
Microtubule (MT) |
Undisclosed |
[19] |
Anti-HER2 IgG1(GH2-75)
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
IgG1 (GH2-75)-vc-MMAE |
Monomethyl auristatin E |
Microtubule (MT) |
Mc-Val-Cit-PABC |
[19] |
Anti-HER2 IgG1(GH2-75) scFv
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
ScFv(GH2-75)-PE38KDEL |
Pseudomonas exotoxin PE38 |
Eukaryotic elongation factor 2 kinase (EEF2K) |
Undisclosed |
[19] |
Anti-HER2 IgG1(GH2-75)-AL1
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
IgG1 (GH2-75)-AL1-MMAE |
Monomethyl auristatin E |
Microtubule (MT) |
Undisclosed |
[19] |
Anti-HER2 IgG1(H32)
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
IgG1 (H32)-vc-MMAE |
Monomethyl auristatin E |
Microtubule (MT) |
Mc-Val-Cit-PABC |
[19] |
Anti-HER2 IgG1(H32) scFv
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
ScFv(H32)-PE38KDEL |
Pseudomonas exotoxin PE38 |
Eukaryotic elongation factor 2 kinase (EEF2K) |
Undisclosed |
[19] |
Anti-HER2 IgG1(H32)-AL1
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
IgG1 (H32)-AL1-MMAE |
Monomethyl auristatin E |
Microtubule (MT) |
Undisclosed |
[19] |
Anti-HER2 mAb
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
ADC2202 |
Undisclosed |
Undisclosed |
Undisclosed |
[20] | |
Anti-HER2 ADC 12-3.1 |
Anti-HER2 ADC 12-3 payload |
Undisclosed |
Anti-HER2 ADC 12-3 linker |
[21] | |
Alpha-HER2-Duo 405 |
Duocarmycin 405 |
Human Deoxyribonucleic acid (hDNA) |
Undisclosed |
[21] | |
Anti-HER2 ADC 2-7 |
Anti-HER2 ADC 2-7 payload |
Undisclosed |
Anti-HER2 ADC 2-7 linker |
[21] | |
Anti-HER2 ADC 3-4 |
Anti-HER2 ADC 3-4 payload |
Undisclosed |
Anti-HER2 ADC 3-4 linker |
[21] | |
Anti-HER2 ADC 4-3 |
Anti-HER2 ADC 4-3 payload |
Undisclosed |
Anti-HER2 ADC 4-3 linker |
[21] | |
Anti-HER2 ADC 5-3 |
Anti-HER2 ADC 5-3 payload |
Undisclosed |
Anti-HER2 ADC 5-3 linker |
[21] | |
Anti-HER2 ADC 6-2 |
Anti-HER2 ADC 6-2 payload |
Undisclosed |
Anti-HER2 ADC 6-2 linker |
[21] | |
Anti-HER2 ADC 7-1 |
Anti-HER2 ADC 7-1 payload |
Undisclosed |
Anti-HER2 ADC 7-1 linker |
[21] | |
Anti-HER2 ADC 8-5 |
Anti-HER2 ADC 8-5 payload |
Undisclosed |
Anti-HER2 ADC 8-5 linker |
[21] | |
Anti-HER2 ADC 9-4 |
Anti-HER2 ADC 9-4 payload |
Undisclosed |
Anti-HER2 ADC 9-4 linker |
[21] | |
Anti-HER2 ADC 10-1 |
Anti-HER2 ADC 10-1 payload |
Undisclosed |
Anti-HER2 ADC 10-1 linker |
[21] | |
Anti-HER2 ADC 11-5 |
Anti-HER2 ADC 11-5 payload |
Undisclosed |
Anti-HER2 ADC 11-5 linker |
[21] | |
Anti-HER2 ADC 12-3.2 |
Anti-HER2 ADC 12-3 payload |
Undisclosed |
Anti-HER2 ADC 12-3 linker |
[21] | |
Anti-HER2 ADC 13-7 |
Anti-HER2 ADC 13-7 payload |
Undisclosed |
Anti-HER2 ADC 13-7 linker |
[21] | |
Anti-HER2 ADC 14-5 |
Anti-HER2 ADC 14-5 payload |
Undisclosed |
Anti-HER2 ADC 14-5 linker |
[21] | |
Anti-HER2 ADC 15-5 |
Anti-HER2 ADC 15-5 payload |
Undisclosed |
Anti-HER2 ADC 15-5 linker |
[21] | |
Anti-HER2 ADC 16-5 |
Anti-HER2 ADC 16-5 payload |
Undisclosed |
Anti-HER2 ADC 16-5 linker |
[21] | |
Anti-HER2 ADC 17-2 |
Anti-HER2 ADC 17-2 payload |
Undisclosed |
Anti-HER2 ADC 17-2 linker |
[21] | |
Anti-HER2 ADC 18-3 |
Anti-HER2 ADC 18-3 payload |
Undisclosed |
Anti-HER2 ADC 18-3 linker |
[21] | |
Anti-HER2 ADC 19-5 |
Anti-HER2 ADC 19-5 payload |
Undisclosed |
Anti-HER2 ADC 19-5 linker |
[21] | |
Anti-HER2 ADC 20-5 |
Anti-HER2 ADC 20-5 payload |
Undisclosed |
Anti-HER2 ADC 20-5 linker |
[21] | |
Anti-HER2 ADC 21-5 |
Anti-HER2 ADC 21-5 payload |
Undisclosed |
Anti-HER2 ADC 21-5 linker |
[21] | |
HER2-HC-H-SS-PBD |
SG2000 |
Human Deoxyribonucleic acid (hDNA) |
H-disulfide linker |
[22] | |
HER2-LC-H-SS-PBD |
SG2000 |
Human Deoxyribonucleic acid (hDNA) |
H-disulfide linker |
[22] | |
HER2-HC-Me-SS-PBD |
SG2000 |
Human Deoxyribonucleic acid (hDNA) |
Me-disulfide linker |
[22] | |
HER2-LC-Me-SS-PBD |
SG2000 |
Human Deoxyribonucleic acid (hDNA) |
Me-disulfide linker |
[22] | |
Anti-HER2 mAb-Compound 9 |
Mertansine DM1 |
Microtubule (MT) |
Anti-HER2 mAb-Compound 9 linker |
[23] | |
Anti-HER2 mAb-Compound 17 |
Mertansine DM4 |
Microtubule (MT) |
Anti-HER2 mAb-Compound 17 linker |
[23] | |
Anti-HER2 mAb-Compound 25 |
Monomethyl auristatin E |
Microtubule (MT) |
Anti-HER2 mAb-Compound 25 linker |
[23] | |
Anti-HER2 mAb-Compound 31 |
Auristatin 0101 |
Microtubule (MT) |
Anti-HER2 mAb-Compound 31 linker |
[23] | |
Anti-HER2 mAb-Compound 36 |
Monomethyl auristatin E |
Microtubule (MT) |
Anti-HER2 mAb-Compound 36 linker |
[23] | |
Anti-HER2 mAb-Compound 43 |
PBD dimer |
Human Deoxyribonucleic acid (hDNA) |
Anti-HER2 mAb-Compound 43 linker |
[23] | |
Anti-HER2 mAb-Compound 49 |
PBD dimer |
Human Deoxyribonucleic acid (hDNA) |
Anti-HER2 mAb-Compound 49 linker |
[23] | |
Anti-HER2 mAb-Compound 55 |
Mertansine DM1 |
Microtubule (MT) |
Anti-HER2 mAb-Compound 55 linker |
[23] | |
Anti-HER2 mAb-Compound 59 |
Mertansine DM4 |
Microtubule (MT) |
Anti-HER2 mAb-Compound 59 linker |
[23] | |
Anti-HER2 mAb-Compound 64 |
Monomethyl auristatin E |
Microtubule (MT) |
Anti-HER2 mAb-Compound 64 linker |
[23] | |
Anti-HER2 mAb-Compound 69 |
Monomethyl auristatin E |
Microtubule (MT) |
Anti-HER2 mAb-Compound 69 linker |
[23] | |
Anti-HER2 mAb-Compound 74 |
PBD dimer |
Human Deoxyribonucleic acid (hDNA) |
Anti-HER2 mAb-Compound 74 linker |
[23] | |
Anti-HER2 mAb-Compound 75 |
Monomethyl auristatin E |
Microtubule (MT) |
Anti-HER2 mAb-Compound 75 linker |
[23] | |
Anti-HER2 mAb-Compound 76 |
Monomethyl auristatin E |
Microtubule (MT) |
Anti-HER2 mAb-Compound 76 linker |
[23] | |
Anti-HER2 mAb-Compound 77 |
Mertansine DM1 |
Microtubule (MT) |
Anti-HER2 mAb-Compound 77 linker |
[23] | |
Anti-HER2 mAb-Compound 78 |
Auristatin 0101 |
Microtubule (MT) |
Anti-HER2 mAb-Compound 78 linker |
[23] | |
Anti-HER2 mAb-Compound 79 |
Auristatin 0101 |
Microtubule (MT) |
Anti-HER2 mAb-Compound 79 linker |
[23] | |
Anti-HER2 mAb-Compound 80 |
Mertansine DM4 |
Microtubule (MT) |
Anti-HER2 mAb-Compound 80 linker |
[23] | |
CN110997010A ADC-1 |
CN110997010A ADC-1 payload |
Undisclosed |
CN110997010A ADC-1 linker |
[24] | |
CN110997010A ADC-2 |
CN110997010A ADC-2 payload |
Undisclosed |
CN110997010A ADC-2 linker |
[24] | |
CN110997010A ADC-3 |
CN110997010A ADC-3 payload |
Undisclosed |
CN110997010A ADC-3 linker |
[24] | |
CN110997010A ADC-4 |
CN110997010A ADC-4 payload |
Undisclosed |
CN110997010A ADC-4 linker |
[24] | |
CN110997010A ADC-5 |
CN110997010A ADC-5 payload |
Undisclosed |
CN110997010A ADC-5 linker |
[24] | |
CN110997010A ADC-6 |
CN110997010A ADC-6 payload |
Undisclosed |
CN110997010A ADC-6 linker |
[24] | |
CN110997010A ADC-7 |
CN110997010A ADC-7 payload |
Undisclosed |
CN110997010A ADC-7 linker |
[24] | |
CN110997010A ADC-8 |
CN110997010A ADC-8 payload |
Undisclosed |
CN110997010A ADC-8 linker |
[24] | |
CN110997010A ADC-9 |
Undisclosed |
Undisclosed |
CN110997010A ADC-9 linker |
[24] | |
CN110997010A ADC-10 |
Undisclosed |
Undisclosed |
CN110997010A ADC-10 linker |
[24] | |
CN110997010A ADC-11 |
Undisclosed |
Undisclosed |
CN110997010A ADC-11 linker |
[24] | |
CN110997010A ADC-12 |
Undisclosed |
Undisclosed |
CN110997010A ADC-12 linker |
[24] | |
CN110997010A ADC-13 |
Undisclosed |
Undisclosed |
CN110997010A ADC-13 linker |
[24] | |
CN110997010A ADC-14 |
Undisclosed |
Undisclosed |
CN110997010A ADC-14 linker |
[24] | |
CN110997010A ADC-15 |
Undisclosed |
Undisclosed |
CN110997010A ADC-15 linker |
[24] | |
CN110997010A ADC-16 |
Undisclosed |
Undisclosed |
CN110997010A ADC-16 linker |
[24] | |
CN110997010A ADC-17 |
Undisclosed |
Undisclosed |
CN110997010A ADC-17 linker |
[24] | |
CN110997010A ADC-18 |
Undisclosed |
Undisclosed |
CN110997010A ADC-18 linker |
[24] | |
CN110997010A ADC-19 |
Undisclosed |
Undisclosed |
CN110997010A ADC-19 linker |
[24] | |
CN110997010A ADC-20 |
Undisclosed |
Undisclosed |
CN110997010A ADC-20 linker |
[24] | |
CN110997010A ADC-21 |
Undisclosed |
Undisclosed |
CN110997010A ADC-21 linker |
[24] | |
CN110997010A ADC-22 |
Undisclosed |
Undisclosed |
CN110997010A ADC-22 linker |
[24] | |
CN110997010A ADC-23 |
Undisclosed |
Undisclosed |
CN110997010A ADC-1 linker |
[24] | |
CN110997010A ADC-24 |
Undisclosed |
Undisclosed |
CN110997010A ADC-3 linker |
[24] | |
CN110997010A ADC-25 |
Undisclosed |
Undisclosed |
CN110997010A ADC-3 linker |
[24] | |
CN110997010A ADC-26 |
Undisclosed |
Undisclosed |
CN110997010A ADC-26 linker |
[24] | |
CN110997010A ADC-27 |
Undisclosed |
Undisclosed |
CN110997010A ADC-5 linker |
[24] | |
CN110997010A ADC-28 |
Undisclosed |
Undisclosed |
CN110997010A ADC-6 linker |
[24] | |
CN110997010A ADC-29 |
Undisclosed |
Undisclosed |
CN110997010A ADC-7 linker |
[24] | |
CN110997010A ADC-30 |
Undisclosed |
Undisclosed |
CN110997010A ADC-8 linker |
[24] | |
CN110997010A ADC-31 |
Undisclosed |
Undisclosed |
CN110997010A ADC-31 linker |
[24] | |
CN110997010A ADC-32 |
Undisclosed |
Undisclosed |
CN110997010A ADC-32 linker |
[24] | |
CN110997010A ADC-33 |
Undisclosed |
Undisclosed |
CN110997010A ADC-33 linker |
[24] | |
CN110997010A ADC-34 |
Undisclosed |
Undisclosed |
CN110997010A ADC-34 linker |
[24] |
Anti-HER2 mAb A114N
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
A114N-Mc-Val-Cit-PABC-MMAE |
Monomethyl auristatin E |
Microtubule (MT) |
Mc-Val-Cit-PABC |
[25] |
Anti-HER2 mAb A114N NNAS
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
A114N NNAS-Mc-Val-Cit-PABC-MMAE |
Monomethyl auristatin E |
Microtubule (MT) |
Mc-Val-Cit-PABC |
[25] |
Anti-HER2 mAb glutamine 295 (Q295)
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
VCit ADC 3a |
Monomethyl auristatin F |
Microtubule (MT) |
DBCO-PEG-VCit-PABC |
[26] | |
EVCit ADC 3c |
Monomethyl auristatin F |
Microtubule (MT) |
DBCO-PEG-EVCit-PABC |
[26] |
Anti-HER2 mAb H-1
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
H-1-vcMMAE |
Monomethyl auristatin E |
Microtubule (MT) |
Mc-Val-Cit-PABC |
[27] |
Anti-HER2 mAb H-3
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
H-3-vcMMAE |
Monomethyl auristatin E |
Microtubule (MT) |
Mc-Val-Cit-PABC |
[27] |
Anti-HER2 mAb H-4
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
H-4-vcMMAE |
Monomethyl auristatin E |
Microtubule (MT) |
Mc-Val-Cit-PABC |
[27] |
Anti-HER2 mAb H32
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
H32-DM1_3.0 |
Mertansine DM1 |
Microtubule (MT) |
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC) |
[28] | |
H32-DM1_3.3 |
Mertansine DM1 |
Microtubule (MT) |
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC) |
[28] | |
H32-DM1_3.7 |
Mertansine DM1 |
Microtubule (MT) |
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC) |
[28] | |
H32-DM1_3.8 |
Mertansine DM1 |
Microtubule (MT) |
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC) |
[28] | |
H32-VCMMAE_2.1 |
Monomethyl auristatin E |
Microtubule (MT) |
Mc-Val-Cit-PABC |
[28] | |
H32-VCMMAE_3.2 |
Monomethyl auristatin E |
Microtubule (MT) |
Mc-Val-Cit-PABC |
[28] | |
H32-VCMMAE_3.8 |
Monomethyl auristatin E |
Microtubule (MT) |
Mc-Val-Cit-PABC |
[28] | |
H32-VCMMAE_6.6 |
Monomethyl auristatin E |
Microtubule (MT) |
Mc-Val-Cit-PABC |
[28] |
Anti-HER2 mAb NNAS
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
NNAS-Mc-Val-Cit-PABC-MMAE |
Monomethyl auristatin E |
Microtubule (MT) |
Mc-Val-Cit-PABC |
[25] |
Anti-HER2 mAb S298N/T299A/Y300S
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
HER2 S298N/T299A/Y300S-Mc-Val-Cit-PABC-MMAE |
Monomethyl auristatin E |
Microtubule (MT) |
Mc-Val-Cit-PABC |
[25] |
Anti-HER2 mAb WT
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
HER2 WT-Mc-Val-Cit-PABC-MMAE |
Monomethyl auristatin E |
Microtubule (MT) |
Mc-Val-Cit-PABC |
[25] | |
Anti-HER-AO-Cys-MC-VC-PABC-MMAE |
Monomethyl auristatin E |
Microtubule (MT) |
Anti-HER-AO-Cys-MC-VC-PABC-MMAE linker |
[25] | |
Anti-HER-MC-VC-PABC-PEG8-Dol10 |
Anti-HER-MC-VC-PABC-PEG8-Dol10 payload |
Undisclosed |
Anti-HER-MC-VC-PABC-PEG8-Dol10 linker |
[25] | |
Anti-HER-AO-Cys-MC-VC-PABC-PEG8-Dol10 |
Anti-HER-AO-Cys-MC-VC-PABC-PEG8-Dol10 payload |
Undisclosed |
Anti-HER-AO-Cys-MC-VC-PABC-PEG8-Dol10 linker |
[25] |
Anti-HER2 scFv-Fc (Ser396Sec)
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
Anti-HER2 scFv-Fc (Ser396Sec)-CN29 |
Monomethyl auristatin F derivative peptide (CN29) |
Microtubule (MT) |
Lodoacetamido-caproyl |
[29] |
Anti-Her2 WT
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
Anti-HER-MC-VC-FABC-MMAE |
Monomethyl auristatin E |
Microtubule (MT) |
Aminooxy-Cys linker |
[30] | |
AntiHER-AO-Cys-MC-VC-FABC-MMAE |
Monomethyl auristatin E |
Microtubule (MT) |
Aminooxy-Cys linker |
[30] | |
Anti-HER-MC-VC-FABC-FEG8-DollO |
DollO |
Undisclosed |
Aminooxy-Cys linker |
[30] | |
Anti-HER-AO-Cys-MC-VC-FABC-FEG8-
DollO |
DollO |
Undisclosed |
Aminooxy-Cys linker |
[30] |
Anti-HER2-D265C
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
Anti-HER2-D265C-30.2060 |
Amanitin 30.206 |
DNA-directed RNA polymerase II subunit RPB2 (POLR2B); DNA-directed RNA polymerase III subunit RPC7 (POLR3G) |
Mc-Val-Ala-PABC |
[31] | |
Anti-HER2-D265C-30.2115 |
Amanitin 30.2115 |
DNA-directed RNA polymerase II subunit RPB2 (POLR2B); DNA-directed RNA polymerase III subunit RPC7 (POLR3G) |
Mc-Val-Ala-PABC |
[31] | |
Anti-HER2-D265C-30.2347 |
Amanitin 30.2347 |
DNA-directed RNA polymerase II subunit RPB2 (POLR2B); DNA-directed RNA polymerase III subunit RPC7 (POLR3G) |
Mc-Val-Ala-PABC |
[31] | |
Anti-HER2-D265C-30.1699 |
Amanitin 30.1699 |
DNA-directed RNA polymerase II subunit RPB2 (POLR2B); DNA-directed RNA polymerase III subunit RPC7 (POLR3G) |
Mc-Val-Ala-PABC |
[31] | |
Anti-HER2-D265C-30.2371 |
Amanitin 30.2371 |
DNA-directed RNA polymerase II subunit RPB2 (POLR2B); DNA-directed RNA polymerase III subunit RPC7 (POLR3G) |
Mc-Val-Ala-PABC |
[31] | |
Anti-HER2-D265C-30.0880 |
Amanitin 30.088 |
DNA-directed RNA polymerase II subunit RPB2 (POLR2B); DNA-directed RNA polymerase III subunit RPC7 (POLR3G) |
Maleimido-caproyl |
[31] | |
Anti-HER2-D265C-30.2867 |
Amanitin 30.2867 |
DNA-directed RNA polymerase II subunit RPB2 (POLR2B); DNA-directed RNA polymerase III subunit RPC7 (POLR3G) |
Maleimido-caproyl |
[31] |
Anti-HER2/neu mAb 4D5
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
4D5-AF (CUAAC) |
Auristatin F |
Microtubule (MT) |
N6-(2-azidoethoxy)carbonyl-L-lysine |
[32] |
Anti-Her2Fab
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
TWI852077B-J8 |
Undisclosed |
Undisclosed |
Undisclosed |
[33] | |
TWI852077B-J13 |
Undisclosed |
Undisclosed |
Undisclosed |
[33] |
Anti-Her2Fab'
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
TWI852077B-J6 |
Monomethyl auristatin E |
Microtubule (MT) |
TWI852077B-C1-linker |
[33] |
Anti-human HER2 mAb
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
HER2-EC4 DAR7.8 |
NAMPT inhibitor 5 |
Nicotinamide phosphoribosyltransferase (NAMPT) |
Open-chain glycine maleimide |
[34] | |
HER2-EC5 |
NAMPT inhibitor 6 |
Nicotinamide phosphoribosyltransferase (NAMPT) |
Open-chain glycine maleimide-PEG |
[34] | |
HER2-EC4 DAR2.7 |
NAMPT inhibitor 5 |
Nicotinamide phosphoribosyltransferase (NAMPT) |
Open-chain glycine maleimide |
[34] | |
HER2-EC3 |
NAMPT inhibitor 4 |
Nicotinamide phosphoribosyltransferase (NAMPT) |
Mc-Val-Ala |
[34] | |
HER2-EC1 |
NAMPT inhibitor 4 |
Nicotinamide phosphoribosyltransferase (NAMPT) |
Maleimido-caproyl |
[34] |
Anvatabart
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
Anvatabart pactil |
Undisclosed |
Undisclosed |
Undisclosed |
[35] |
Az-LacNAc-Tras Ab7
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
HER2-gsADC-41 |
Monomethyl auristatin E |
Microtubule (MT) |
Bicyclononyne derivative 6e |
[36] | |
HER2-gsADC-42 |
Monomethyl auristatin E |
Microtubule (MT) |
PEGylation linker 6l |
[36] | |
HER2-gsADC-43 |
Monomethyl auristatin E |
Microtubule (MT) |
PEGylation linker 6m |
[36] | |
HER2-gsADC-44 |
Monomethyl auristatin E |
Microtubule (MT) |
Noncleavable linker 6s |
[36] | |
HER2-gsADC-45 |
Monomethyl auristatin E |
Microtubule (MT) |
Noncleavable linker 6t |
[36] |
Azido-tagged trastuzumab (Ab2)
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
HER2-gsADC-5 |
Monomethyl auristatin E |
Microtubule (MT) |
Azadibenzocylooctyne-amine derivative 6d |
[36] | |
HER2-gsADC-6 |
Monomethyl auristatin E |
Microtubule (MT) |
Bicyclononyne derivative 6e |
[36] | |
HER2-gsADC-7 |
Monomethyl auristatin E |
Microtubule (MT) |
PEGylation linker 6m |
[36] | |
HER2-gsADC-8 |
Monomethyl auristatin E |
Microtubule (MT) |
Glycosyl PEGylation linker 6r |
[36] |
Azido-tagged trastuzumab (Ab3)
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
HER2-gsADC-9 |
Monomethyl auristatin E |
Microtubule (MT) |
Linear alkyne 6f |
[36] | |
HER2-gsADC-10 |
Monomethyl auristatin E |
Microtubule (MT) |
PEGylation linker 6g |
[36] | |
HER2-gsADC-11 |
Monomethyl auristatin E |
Microtubule (MT) |
PEGylation linker 6h |
[36] | |
HER2-gsADC-12 |
Monomethyl auristatin E |
Microtubule (MT) |
PEGylation linker 6i |
[36] | |
HER2-gsADC-13 |
Monomethyl auristatin E |
Microtubule (MT) |
PEGylation linker 6j |
[36] | |
HER2-gsADC-14 |
Monomethyl auristatin E |
Microtubule (MT) |
PEGylation linker 6k |
[36] | |
HER2-gsADC-15 |
Monomethyl auristatin E |
Microtubule (MT) |
PEGylation linker 6l |
[36] | |
HER2-gsADC-16 |
Monomethyl auristatin E |
Microtubule (MT) |
PEGylation linker 6m |
[36] | |
HER2-gsADC-17 |
Monomethyl auristatin E |
Microtubule (MT) |
Noncleavable linker 6t |
[36] |
Azido-tagged trastuzumab (Ab5)
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
HER2-gsADC-22 |
Monomethyl auristatin E |
Microtubule (MT) |
Linear alkyne 6f |
[36] | |
HER2-gsADC-23 |
Monomethyl auristatin E |
Microtubule (MT) |
PEGylation linker 6g |
[36] | |
HER2-gsADC-24 |
Monomethyl auristatin E |
Microtubule (MT) |
PEGylation linker 6h |
[36] | |
HER2-gsADC-25 |
Monomethyl auristatin E |
Microtubule (MT) |
PEGylation linker 6i |
[36] | |
HER2-gsADC-26 |
Monomethyl auristatin E |
Microtubule (MT) |
PEGylation linker 6j |
[36] | |
HER2-gsADC-27 |
Monomethyl auristatin E |
Microtubule (MT) |
PEGylation linker 6k |
[36] | |
HER2-gsADC-28 |
Monomethyl auristatin E |
Microtubule (MT) |
PEGylation linker 6l |
[36] | |
HER2-gsADC-29 |
Monomethyl auristatin E |
Microtubule (MT) |
PEGylation linker 6m |
[36] | |
HER2-gsADC-30 |
Monomethyl auristatin E |
Microtubule (MT) |
Glycosyl PEGylation linker 6o |
[36] | |
HER2-gsADC-31 |
Monomethyl auristatin E |
Microtubule (MT) |
Glycosyl PEGylation linker 6p |
[36] | |
HER2-gsADC-32 |
Monomethyl auristatin E |
Microtubule (MT) |
Glycosyl PEGylation linker 6q |
[36] | |
HER2-gsADC-33 |
Monomethyl auristatin E |
Microtubule (MT) |
Glycosyl PEGylation linker 6r |
[36] |
Azido-tagged trastuzumab (Ab6)
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
HER2-gsADC-34 |
Monomethyl auristatin E |
Microtubule (MT) |
Linear alkyne 6f |
[36] | |
HER2-gsADC-35 |
Monomethyl auristatin E |
Microtubule (MT) |
PEGylation linker 6g |
[36] | |
HER2-gsADC-36 |
Monomethyl auristatin E |
Microtubule (MT) |
PEGylation linker 6h |
[36] | |
HER2-gsADC-37 |
Monomethyl auristatin E |
Microtubule (MT) |
PEGylation linker 6i |
[36] | |
HER2-gsADC-38 |
Monomethyl auristatin E |
Microtubule (MT) |
PEGylation linker 6j |
[36] | |
HER2-gsADC-39 |
Monomethyl auristatin E |
Microtubule (MT) |
PEGylation linker 6k |
[36] | |
HER2-gsADC-40 |
Monomethyl auristatin E |
Microtubule (MT) |
PEGylation linker 6l |
[36] |
B2
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
B2-MMAE |
Monomethyl auristatin E |
Microtubule (MT) |
Mc-Val-Cit-PABC |
[37] |
BA-130-00-01
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
LC A032D/HC |
LC A032D/HC payload |
Undisclosed |
LC A032D/HC linker |
[38] |
BA-130-03-02
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
LC A032D/HC Y052K |
LC A032D/HC Y052K payload |
Undisclosed |
LC A032D/HC Y052K linker |
[38] |
BA-130-03-05
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
LC A032D/HC G056K |
LC A032D/HC G056K payload |
Undisclosed |
LC A032D/HC G056K linker |
[38] |
BA-130-03-06
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
LC A032D/HC T058D |
LC A032D/HC T058D payload |
Undisclosed |
LC A032D/HC T058D linker |
[38] |
BA-130-03-07
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
LC A032D/HC A106E |
LC A032D/HC A106E payload |
Undisclosed |
LC A032D/HC A106E linker |
[38] |
BA-130-03-08
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
LC A032D/HC S119E |
LC A032D/HC S119E payload |
Undisclosed |
LC A032D/HC S119E linker |
[38] |
BAY-865
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
HER2 KSP-ADC 1.1 |
Pyrrole based kinesin spindle protein inhibitor |
Kinesin-like protein KIF11 (KIF11) |
Kinesin spindle protein inhibitor (KSPi)-ADC linker 1 |
[39] | |
HER2 KSP-ADC 1.2 |
Pyrrole based kinesin spindle protein inhibitor |
Kinesin-like protein KIF11 (KIF11) |
Kinesin spindle protein inhibitor (KSPi)-ADC linker 2 |
[39] | |
HER2 KSP-ADC 1.3 |
Pyrrole based kinesin spindle protein inhibitor |
Kinesin-like protein KIF11 (KIF11) |
Kinesin spindle protein inhibitor (KSPi)-ADC linker 3 |
[39] | |
HER2 KSP-ADC 1.4 |
Pyrrole based kinesin spindle protein inhibitor |
Kinesin-like protein KIF11 (KIF11) |
Kinesin spindle protein inhibitor (KSPi)-ADC linker 4 |
[39] | |
HER2 KSP-ADC 2.1 |
Pyrrole based kinesin spindle protein inhibitor |
Kinesin-like protein KIF11 (KIF11) |
Kinesin spindle protein inhibitor (KSPi)-ADC linker 5 |
[39] | |
HER2 KSP-ADC 2.2 |
Pyrrole based kinesin spindle protein inhibitor |
Kinesin-like protein KIF11 (KIF11) |
Kinesin spindle protein inhibitor (KSPi)-ADC linker 6 |
[39] |
BB02E
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
BB02E-MMAE |
Monomethyl auristatin E |
Microtubule (MT) |
Mc-Val-Cit-PABC |
[40] |
BB03E
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
BB03E-MMAE |
Monomethyl auristatin E |
Microtubule (MT) |
Mc-Val-Cit-PABC |
[40] |
BB03E-A
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
BB03E-A-MMAE |
Monomethyl auristatin E |
Microtubule (MT) |
Mc-Val-Cit-PABC |
[40] |
BB04E
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
BB04E-MMAE |
Monomethyl auristatin E |
Microtubule (MT) |
Mc-Val-Cit-PABC |
[40] |
BB05E
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
BB05E-MMAE |
Monomethyl auristatin E |
Microtubule (MT) |
Mc-Val-Cit-PABC |
[40] |
BCN-trastuzumab tras-v1a-145
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
Trast-v1a-145-PF03 |
Undisclosed |
Undisclosed |
Undisclosed |
[41] | |
Trast-v1a-145-PF09 |
Undisclosed |
Undisclosed |
Undisclosed |
[41] | |
Trast-v1a-145-PF12 |
Undisclosed |
Undisclosed |
Undisclosed |
[41] | |
Trast-v1a-145-PF13 |
Undisclosed |
Undisclosed |
Undisclosed |
[41] | |
Trast-v1a-145-PF17 |
Undisclosed |
Undisclosed |
Undisclosed |
[41] | |
Tras-v1a-145-PF19 |
Undisclosed |
Undisclosed |
Undisclosed |
[41] | |
Trast-v1a-145-PF21 |
Undisclosed |
Undisclosed |
Undisclosed |
[41] |
bis-azido-trastuzumab tras-v1a
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
Tras-v1a-PF29 |
Undisclosed |
Undisclosed |
Undisclosed |
[41] |
bis-azido-trastuzumab trast-v1a
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
Trast-v1a-PF22 |
Undisclosed |
Undisclosed |
Undisclosed |
[41] | |
Rit-v1a-145-PF22 |
Undisclosed |
Undisclosed |
Undisclosed |
[41] | |
Trast-v1a-PF23 |
Undisclosed |
Undisclosed |
Undisclosed |
[41] | |
Trast-v1a- (PF07)2 |
Undisclosed |
Undisclosed |
Undisclosed |
[41] | |
Trast-v1a- (PF10)2 |
Undisclosed |
Undisclosed |
Undisclosed |
[41] | |
Trast-v1a- (PF11)2 |
Undisclosed |
Undisclosed |
Undisclosed |
[41] | |
Trast-v1a- (PF14)2 |
Undisclosed |
Undisclosed |
Undisclosed |
[41] | |
Trast-v1a- (PF15)2 |
Undisclosed |
Undisclosed |
Undisclosed |
[41] | |
Trast-v1a-145-PF27 |
Undisclosed |
Undisclosed |
Undisclosed |
[41] | |
Trast-v1a- (PF20)2 |
Undisclosed |
Undisclosed |
Undisclosed |
[41] |
CHO-G2F-Tras (Ab4)
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
HER2-gsADC-18 |
Monomethyl auristatin E |
Microtubule (MT) |
ThioPz linker 6a |
[36] | |
HER2-gsADC-19 |
Monomethyl auristatin E |
Microtubule (MT) |
2-Aminobenzamide oxime |
[36] | |
HER2-gsADC-20 |
Monomethyl auristatin E |
Microtubule (MT) |
Hydroxylamine derivative 6c |
[36] | |
HER2-gsADC-21 |
Monomethyl auristatin E |
Microtubule (MT) |
PEGylation linker 6n |
[36] |
CHO-S2G2F-Tras (Ab1)
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
HER2-gsADC-1 |
Monomethyl auristatin E |
Microtubule (MT) |
ThioPz linker 6a |
[36] | |
HER2-gsADC-2 |
Monomethyl auristatin E |
Microtubule (MT) |
2-Aminobenzamide oxime |
[36] | |
HER2-gsADC-3 |
Monomethyl auristatin E |
Microtubule (MT) |
Hydroxylamine derivative 6c |
[36] | |
HER2-gsADC-4 |
Monomethyl auristatin E |
Microtubule (MT) |
PEGylation linker 6n |
[36] |
CN105828840B_ADC-102 antibody
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
CN105828840B ADC-102 |
CN105828840B_ADC-102 payload |
Undisclosed |
CN105828840B_ADC-102 linker |
[42] |
CN105828840B_ADC-103 antibody
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
CN105828840B ADC-103 |
CN105828840B_ADC-103 payload |
Undisclosed |
CN105828840B_ADC-103 linker |
[42] |
CN105828840B_ADC-105 antibody
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
CN105828840B ADC-105 |
CN105828840B_ADC-105 payload |
Undisclosed |
CN105828840B_ADC-105 linker |
[42] |
CN105828840B_ADC-106 antibody
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
CN105828840B ADC-106 |
CN105828840B_ADC-106 payload |
Undisclosed |
CN105828840B_ADC-106 linker |
[42] |
CN105828840B_ADC-107 antibody
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
CN105828840B ADC-107 |
CN105828840B_ADC-107 payload |
Undisclosed |
CN105828840B_ADC-107 linker |
[42] |
CN105828840B_ADC-109 antibody
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
CN105828840B ADC-109 |
CN105828840B_ADC-109 payload |
Undisclosed |
CN105828840B_ADC-109 linker |
[42] |
CN105828840B_ADC-112 antibody
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
CN105828840B ADC-112 |
CN105828840B_ADC-112 payload |
Undisclosed |
CN105828840B_ADC-112 linker |
[42] |
CN105828840B_ADC-113 antibody
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
CN105828840B ADC-113 |
CN105828840B_ADC-113 payload |
Undisclosed |
CN105828840B_ADC-113 linker |
[42] |
CN105828840B_ADC-114 antibody
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
CN105828840B ADC-114 |
CN105828840B_ADC-114 payload |
Undisclosed |
CN105828840B_ADC-114 linker |
[42] |
CN105828840B_ADC-117 antibody
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
CN105828840B ADC-117 |
CN105828840B_ADC-117 payload |
Undisclosed |
CN105828840B_ADC-117 linker |
[42] |
CN105828840B_ADC-118 antibody
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
CN105828840B ADC-118 |
CN105828840B_ADC-118 payload |
Undisclosed |
CN105828840B_ADC-118 linker |
[42] |
CN105828840B_ADC-119 antibody
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
CN105828840B ADC-119 |
CN105828840B_ADC-119 payload |
Undisclosed |
CN105828840B_ADC-119 linker |
[42] |
CN105828840B_ADC-121 antibody
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
CN105828840B ADC-121 |
CN105828840B_ADC-121 payload |
Undisclosed |
CN105828840B_ADC-121 linker |
[42] |
CN105828840B_ADC-123 antibody
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
CN105828840B ADC-123 |
CN105828840B_ADC-123 payload |
Undisclosed |
CN105828840B_ADC-123 linker |
[42] |
Coprelotamab
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
Coprelotamab-ADC-Tb3-1 |
Coprelotamab-ADC-Tb3-1 payload |
Undisclosed |
Coprelotamab-ADC-Tb3-1 linker |
[7] | |
Coprelotamab-ADC-Tb3-2 |
Coprelotamab-ADC-Tb3-2 payload |
Undisclosed |
Coprelotamab-ADC-Tb3-2 linker |
[7] | |
Coprelotamab-ADC-Tb3-3 |
Coprelotamab-ADC-Tb3-3 payload |
Undisclosed |
Coprelotamab-ADC-Tb3-3 linker |
[7] | |
Coprelotamab-ADC-Tb3-4 |
Coprelotamab-ADC-Tb3-4 payload |
Undisclosed |
Coprelotamab-ADC-Tb3-4 linker |
[7] | |
Coprelotamab-ADC-Tb3-5 |
Coprelotamab-ADC-Tb3-5 payload |
Undisclosed |
Coprelotamab-ADC-Tb3-5 linker |
[7] | |
Coprelotamab-ADC-Tb3-6 |
Coprelotamab-ADC-Tb3-6 payload |
Undisclosed |
Coprelotamab-ADC-Tb3-6 linker |
[7] | |
Coprelotamab-ADC-Tb3-7 |
Coprelotamab-ADC-Tb3-7 payload |
Undisclosed |
Coprelotamab-ADC-Tb3-7 linker |
[7] | |
Coprelotamab-ADC-Tb3-8 |
Coprelotamab-ADC-Tb3-8 payload |
Undisclosed |
Coprelotamab-ADC-Tb3-8 linker |
[7] | |
Coprelotamab-ADC-Tb3-9 |
Coprelotamab-ADC-Tb3-9 payload |
Undisclosed |
Coprelotamab-ADC-Tb3-9 linker |
[7] | |
Coprelotamab-ADC-Tb3-10 |
Coprelotamab-ADC-Tb3-10 payload |
Undisclosed |
Coprelotamab-ADC-Tb3-10 linker |
[7] |
Cys-mutant trastuzumab
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
Cys-mutant trastuzumab-biotin |
Biotin |
Undisclosed |
Undisclosed |
[43] |
degly-ISOmAb
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
Degly-ISOmAb-1-mc-vc-PAB-MMAE |
Monomethyl auristatin E |
Microtubule (MT) |
Mc-Val-Cit-PABC |
[44] |
degly-mAb1
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
Degly-mAb1-1-mc-vc-PAB-MMAE |
Monomethyl auristatin E |
Microtubule (MT) |
Mc-Val-Cit-PABC |
[44] |
DVD-IgG
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
177Lu-CHX-A"-DTPA-PODS-DVD |
Lutetium-177 |
Undisclosed |
PODS-CHX-A"-DTPA |
[45] |
Enfertuzumab
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
Enfertuzumab-compound 1100 |
Undisclosed |
Undisclosed |
Undisclosed |
[46] | |
Enfertuzumab-compound 1101 |
Undisclosed |
Undisclosed |
Undisclosed |
[46] | |
Enfertuzumab-compound 1102 |
Undisclosed |
Undisclosed |
Undisclosed |
[46] | |
Enfertuzumab-compound 1103 |
Undisclosed |
Undisclosed |
Undisclosed |
[46] | |
Enfertuzumab-compound 1574 |
Undisclosed |
Undisclosed |
Undisclosed |
[46] | |
Enfertuzumab-compound 1105 |
Undisclosed |
Undisclosed |
Undisclosed |
[46] | |
Enfertuzumab-compound 1106 |
Undisclosed |
Undisclosed |
Undisclosed |
[46] | |
Enfertuzumab-compound 1199 |
Undisclosed |
Undisclosed |
Undisclosed |
[46] |
Engineered trastuzumab
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
Trastuzumab-C239I-SG3600 |
N10-beta-glucuronide SG3200 |
Human Deoxyribonucleic acid (hDNA) |
Mal-PEG8-Val-Ala-PABC |
[47] | |
Trastuzumab-C239I-SG3400 |
SG3200 |
Human Deoxyribonucleic acid (hDNA) |
Mal-PEG8-Val-Ala-PABC |
[47] | |
Engineered HER-SG3227 |
SG2219 |
Human Deoxyribonucleic acid (hDNA) |
Acetamide-PEG4-Val-Ala-PABA |
[48] |
FM2b-F
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
FM2b-F-D2 |
Monomethyl auristatin E |
Microtubule (MT) |
Mc-Val-Cit-PABC |
[49] |
FM2b-K
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
FM2b-K-D2 |
Monomethyl auristatin E |
Microtubule (MT) |
Mc-Val-Cit-PABC |
[49] |
FM2b-S
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
FM2b-S-D2 |
Monomethyl auristatin E |
Microtubule (MT) |
Mc-Val-Cit-PABC |
[49] |
FM2b-Y
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
FM2b-Y-D2 |
Monomethyl auristatin E |
Microtubule (MT) |
Mc-Val-Cit-PABC |
[49] |
Gancotamab
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
Gancotamab-ADC-Tb3-1 |
Gancotamab-ADC-Tb3-1 payload |
Undisclosed |
Gancotamab-ADC-Tb3-1 linker |
[7] | |
Gancotamab-ADC-Tb3-2 |
Gancotamab-ADC-Tb3-2 payload |
Undisclosed |
Gancotamab-ADC-Tb3-2 linker |
[7] | |
Gancotamab-ADC-Tb3-3 |
Gancotamab-ADC-Tb3-3 payload |
Undisclosed |
Gancotamab-ADC-Tb3-3 linker |
[7] | |
Gancotamab-ADC-Tb3-4 |
Gancotamab-ADC-Tb3-4 payload |
Undisclosed |
Gancotamab-ADC-Tb3-4 linker |
[7] | |
Gancotamab-ADC-Tb3-5 |
Gancotamab-ADC-Tb3-5 payload |
Undisclosed |
Gancotamab-ADC-Tb3-5 linker |
[7] | |
Gancotamab-ADC-Tb3-6 |
Gancotamab-ADC-Tb3-6 payload |
Undisclosed |
Gancotamab-ADC-Tb3-6 linker |
[7] | |
Gancotamab-ADC-Tb3-7 |
Gancotamab-ADC-Tb3-7 payload |
Undisclosed |
Gancotamab-ADC-Tb3-7 linker |
[7] | |
Gancotamab-ADC-Tb3-8 |
Gancotamab-ADC-Tb3-8 payload |
Undisclosed |
Gancotamab-ADC-Tb3-8 linker |
[7] | |
Gancotamab-ADC-Tb3-9 |
Gancotamab-ADC-Tb3-9 payload |
Undisclosed |
Gancotamab-ADC-Tb3-9 linker |
[7] | |
Gancotamab-ADC-Tb3-10 |
Gancotamab-ADC-Tb3-10 payload |
Undisclosed |
Gancotamab-ADC-Tb3-10 linker |
[7] |
GGG-IL15Ralpha-IL15 208
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
BCN-PEG12-IL15Ralpha-IL15 |
Undisclosed |
Undisclosed |
Undisclosed |
[41] |
H01L02
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
WO2022228495A1 ADC-73 |
WO2022228495A1 ADC-73 payload |
Undisclosed |
WO2022228495A1 ADC-73 linker |
[50] | |
H01L02-Dxd |
DX-8951 derivative (DXd) |
DNA topoisomerase 1 (TOP1) |
Mc-Gly-Gly-Phe-Gly |
[51] |
H02L02
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
H02L02-Dxd |
DX-8951 derivative (DXd) |
DNA topoisomerase 1 (TOP1) |
Mc-Gly-Gly-Phe-Gly |
[51] |
H02L03
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
H02L03-Dxd |
DX-8951 derivative (DXd) |
DNA topoisomerase 1 (TOP1) |
Mc-Gly-Gly-Phe-Gly |
[51] |
H04L02
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
H04L02-Dxd |
DX-8951 derivative (DXd) |
DNA topoisomerase 1 (TOP1) |
Mc-Gly-Gly-Phe-Gly |
[51] |
HER2 (L328C)
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
anti-HER2 Ab (L328C)-vcMMAE |
Monomethyl auristatin E |
Microtubule (MT) |
Mc-Val-Cit-PABC |
[52] |
HER2-C Anti-ody
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
HER2-C Antibody-Compound (X) |
HER2-C Antibody-Compound (X) payload |
Undisclosed |
HER2-C Antibody-Compound (X) linker |
[53] | |
HER2-C Antibody-Compound (XI) |
HER2-C Antibody-Compound (XI) payload |
Undisclosed |
HER2-C Antibody-Compound (XI) linker |
[53] | |
HER2-C Antibody-Compound (XIV) |
HER2-C Antibody-Compound (XIV) payload |
Undisclosed |
HER2-C Antibody-Compound (XIV) linker |
[53] | |
HER2-C Antibody-Compound (XVIII) |
HER2-C Antibody-Compound (XVIII) payload |
Undisclosed |
HER2-C Antibody-Compound (XVIII) linker |
[53] | |
HER2-C Antibody-Compound (Ie) |
HER2-C Antibody-Compound (Ie) payload |
Undisclosed |
HER2-C Antibody-Compound (Ie) linker |
[53] | |
HER2-C Antibody-Compound (XIX) |
HER2-C Antibody-Compound (XIX) payload |
Undisclosed |
HER2-C Antibody-Compound (XIX) linker |
[53] | |
HER2-C Antibody-Compound (Ii) |
HER2-C Antibody-Compound (Ii) payload |
Undisclosed |
HER2-C Antibody-Compound (Ii) linker |
[53] | |
HER2-C Antibody-Compound (XLI) |
HER2-C Antibody-Compound (XLI) payload |
Undisclosed |
HER2-C Antibody-Compound (XLI) linker |
[53] | |
HER2-C Antibody-Compound (XVI) |
HER2-C Antibody-Compound (XIX) payload |
Undisclosed |
HER2-C Antibody-Compound (XIX) linker |
[53] | |
HER2-C Antibody-Compound (XL) |
HER2-C Antibody-Compound (XL) payload |
Undisclosed |
HER2-C Antibody-Compound (XL) linker |
[53] | |
HER2-C Antibody-Compound (XLIII) |
HER2-C Antibody-Compound (XLIII) payload |
Undisclosed |
HER2-C Antibody-Compound (XLIII) linker |
[53] | |
HER2-C Antibody-Compound (XLII) |
HER2-C Antibody-Compound (XLII) payload |
Undisclosed |
HER2-C Antibody-Compound (XLII) linker |
[53] | |
HER2-C Antibody-Compound (XV) |
HER2-C Antibody-Compound (XV) payload |
Undisclosed |
HER2-C Antibody-Compound (XV) linker |
[53] |
Her2-PT-A114C-hGl
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
Her2-PT-A114C-hGl- LP2 |
Undisclosed |
Undisclosed |
Undisclosed |
[54] | |
Her2-PT-A114C-hGl-LP48 |
Undisclosed |
Undisclosed |
Undisclosed |
[54] |
Her2-PT-H16-K222R-hG1
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
Her2-PT-H16-K222R- hG1-LP1 |
Undisclosed |
Undisclosed |
Undisclosed |
[54] | |
Her2-PT-H16-K222R- hGl-LP13 |
Undisclosed |
Undisclosed |
Undisclosed |
[54] | |
Her2-PT-H16-K222R- hGl-LP49 |
Undisclosed |
Undisclosed |
Undisclosed |
[54] | |
Her2-PT-H16-K222R- hGl-LP19 |
Undisclosed |
Undisclosed |
Undisclosed |
[54] |
Her2-PT-H16-K222R-Hg1
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
Her2-PT-H16-K222R- hG1-LP6 |
Undisclosed |
Undisclosed |
Undisclosed |
[54] |
Her2-PT-H7C-K222R-hGl
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
Her2-PT-H7C-K222R- hGl-LP19 |
Undisclosed |
Undisclosed |
Undisclosed |
[54] |
Her2-PT-LCQ05- K222R-hGl
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
Her2-PT-LCQ05- K222R-hGl-LP19 |
Undisclosed |
Undisclosed |
Undisclosed |
[54] |
Hertuzumab
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
Hertuzumab vedotin |
Monomethyl auristatin E |
Microtubule (MT) |
Mc-Val-Cit-PABC |
[55] | |
Disitamab-ADC-Tb3-1 |
Disitamab-ADC-Tb3-1 payload |
Undisclosed |
Disitamab-ADC-Tb3-1 linker |
[7] | |
Disitamab-ADC-Tb3-2 |
Disitamab-ADC-Tb3-2 payload |
Undisclosed |
Disitamab-ADC-Tb3-2 linker |
[7] | |
Disitamab-ADC-Tb3-3 |
Disitamab-ADC-Tb3-3 payload |
Undisclosed |
Disitamab-ADC-Tb3-3 linker |
[7] | |
Disitamab-ADC-Tb3-4 |
Disitamab-ADC-Tb3-4 payload |
Undisclosed |
Disitamab-ADC-Tb3-4 linker |
[7] | |
Disitamab-ADC-Tb3-5 |
Disitamab-ADC-Tb3-5 payload |
Undisclosed |
Disitamab-ADC-Tb3-5 linker |
[7] | |
Disitamab-ADC-Tb3-6 |
Disitamab-ADC-Tb3-6 payload |
Undisclosed |
Disitamab-ADC-Tb3-6 linker |
[7] | |
Disitamab-ADC-Tb3-7 |
Disitamab-ADC-Tb3-7 payload |
Undisclosed |
Disitamab-ADC-Tb3-7 linker |
[7] | |
Disitamab-ADC-Tb3-8 |
Disitamab-ADC-Tb3-8 payload |
Undisclosed |
Disitamab-ADC-Tb3-8 linker |
[7] | |
Disitamab-ADC-Tb3-9 |
Disitamab-ADC-Tb3-9 payload |
Undisclosed |
Disitamab-ADC-Tb3-9 linker |
[7] | |
Disitamab-ADC-Tb3-10 |
Disitamab-ADC-Tb3-10 payload |
Undisclosed |
Disitamab-ADC-Tb3-10 linker |
[7] |
HS627
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
WO2024140447A1 ADC 1 |
WO2024140447A1 ADC 1 Payload |
Undisclosed |
WO2024140447A1 ADC 1 Linker |
[56] | |
WO2024140447A1 ADC 3 |
WO2024140447A1 ADC 1 Payload |
Undisclosed |
WO2024140447A1 ADC 3 Linker |
||
WO2024140447A1 ADC 5 |
WO2024140447A1 ADC 1 Payload |
Undisclosed |
WO2024140447A1 ADC 4 Linker |
||
WO2024140447A1 ADC 7 |
WO2024140447A1 ADC 1 Payload |
Undisclosed |
WO2024140447A1 ADC 7 Linker |
||
WO2024140447A1 ADC 9 |
WO2024140447A1 ADC 1 Payload |
Undisclosed |
WO2024140447A1 ADC 9 Linker |
||
WO2024140447A1 ADC 11 |
WO2024140447A1 ADC 1 Payload |
Undisclosed |
WO2024140447A1 ADC 11 Linker |
||
WO2024140447A1 ADC 13 |
WO2024140447A1 ADC 13 Payload |
Undisclosed |
WO2024140447A1 ADC 13 Linker |
||
WO2024140447A1 ADC 15 |
WO2024140447A1 ADC 13 Payload |
Undisclosed |
WO2024140447A1 ADC 15 Linker |
||
WO2024140447A1 ADC 17 |
WO2024140447A1 ADC 13 Payload |
Undisclosed |
WO2024140447A1 ADC 17 Linker |
||
WO2024140447A1 ADC 19 |
WO2024140447A1 ADC 13 Payload |
Undisclosed |
WO2024140447A1 ADC 3 Linker |
||
WO2024140447A1 ADC 21 |
WO2024140447A1 ADC 13 Payload |
Undisclosed |
WO2024140447A1 ADC 21 Linker |
||
WO2024140447A1 ADC 23 |
WO2024140447A1 ADC 13 Payload |
Undisclosed |
WO2024140447A1 ADC 23 Linker |
||
WO2024140447A1 ADC 25 |
WO2024140447A1 ADC 1 Payload |
Undisclosed |
WO2024140447A1 ADC 25 Linker |
||
WO2024140450A1 7-[N- (HS627-mc-Gly-Gly-Phe-Gly-ha-Ac), N- (S)-methoxyisopropyl]aminomethyl-10,11-methylenedioxycamptothecin |
Undisclosed |
Undisclosed |
Undisclosed |
[57] | |
WO2024140450A1 7-[N- (HS627-Ac-PEG2-Val-Ala-PABC), N- (S)-methoxyisopropyl]aminomethyl-10,11-methylenedioxycamptothecin |
Undisclosed |
Undisclosed |
Undisclosed |
[57] | |
WO2024140450A1 7-[N- (HS627-Ac-PEG2-Gly-Gly-Leu-Gly-ha-Ac), N- (S)-methyl-2-oxoethyl]-10,11-methylenedi-10,11-dihydroxycamptothecin |
Undisclosed |
Undisclosed |
Undisclosed |
[57] | |
WO2024140450A1 7-[N- (HS627-Ac-PEG2-Val-Ala-PABC), N-methoxyethyl]aminoethyl-10,11-methylenedioxycamptothecin |
Undisclosed |
Undisclosed |
Undisclosed |
[57] | |
WO2024140450A1 7-[N- (HS627-Ac-PEG2-Gly-Gly-Leu-Gly-ha-Ac), N-methoxyethyl]aminoethyl-10,11-methylenedi-6-mercaptopurine |
Undisclosed |
Undisclosed |
Undisclosed |
[57] | |
WO2024140450A1 7-[N- (HS627-Ac-PEG2-Gly-Gly-Lys-Gly-ha-Ac), N- (S)-methylisopropyl]aminoethyl-10,11-methylenedi-10,11-ethenylhyerocytosine |
Undisclosed |
Undisclosed |
Undisclosed |
[57] | |
WO2024140450A1 7-[N- (HS627-Ac-PEG2-Gly-Lys-PABC), N- (S)-methylisopropyl]aminoethyl-10,11-methylenedi-10,11-ethenylhydragranin 4.3 |
Undisclosed |
Undisclosed |
Undisclosed |
[57] | |
HS627 ADC1 |
Undisclosed |
Undisclosed |
Undisclosed |
[58] | |
HS627 ADC2 |
Undisclosed |
Undisclosed |
Undisclosed |
[58] | |
HS627 ADC3 |
Undisclosed |
Undisclosed |
Undisclosed |
[58] | |
CN116785448A ADC1 |
CN116785448A ADC1 payload |
Undisclosed |
CN116785448A ADC8 linker |
[59] | |
CN116785448A ADC2 |
CN116785448A ADC2 payload |
Undisclosed |
CN116785448A ADC2 linker |
[59] | |
CN116785448A ADC3 |
CN116785448A ADC5 payload |
Undisclosed |
CN116785448A ADC8 linker |
[59] | |
CN116785448A ADC4 |
CN116785448A ADC4 payload |
Undisclosed |
CN116785448A ADC4 linker |
[59] | |
CN116785448A ADC5 |
CN116785448A ADC5 payload |
Undisclosed |
CN116785448A ADC5 linker |
[59] | |
CN116785448A ADC6 |
CN116785448A ADC6 payload |
Undisclosed |
CN116785448A ADC6 linker |
[59] | |
CN116785448A ADC7 |
CN116785448A ADC7 payload |
Undisclosed |
CN116785448A ADC7 linker |
[59] | |
CN116785448A ADC8 |
CN116785448A ADC8 payload |
Undisclosed |
CN116785448A ADC8 linker |
[59] | |
HS627- (C1)2 |
undisclosed |
Undisclosed |
Undisclosed |
[60] | |
HS627- (C1)4 |
undisclosed |
Undisclosed |
Undisclosed |
[60] | |
(C6)4-HS627- (C1)2 |
undisclosed |
Undisclosed |
Undisclosed |
[60] | |
HS627- (C2)2 |
undisclosed |
Undisclosed |
Undisclosed |
[60] | |
HS627- (C4)4 3.8 |
undisclosed |
Undisclosed |
Undisclosed |
[60] | |
(C0)4-HS627- (C2)2 |
undisclosed |
Undisclosed |
Undisclosed |
[60] | |
HS627- (C3)2 |
undisclosed |
Undisclosed |
Undisclosed |
[60] | |
HS627- (C3)4 |
undisclosed |
Undisclosed |
Undisclosed |
[60] | |
(C0)4-HS627- (C3)2 |
undisclosed |
Undisclosed |
Undisclosed |
[60] | |
HS627- (C4)2 |
undisclosed |
Undisclosed |
Undisclosed |
[60] | |
HS627- (C4)4 3.7 |
undisclosed |
Undisclosed |
Undisclosed |
[60] | |
(C6)4-HS627- (C4)2 |
undisclosed |
Undisclosed |
Undisclosed |
[60] | |
HS627- (C5)2 |
undisclosed |
Undisclosed |
Undisclosed |
[60] | |
HS627- (C5)4 |
undisclosed |
Undisclosed |
Undisclosed |
[60] | |
(C0)4-HS627- (C5)2 |
undisclosed |
Undisclosed |
Undisclosed |
[60] | |
HS627- (C6)2 |
undisclosed |
Undisclosed |
Undisclosed |
[60] | |
HS627- (C6)4 |
undisclosed |
Undisclosed |
Undisclosed |
[60] | |
(C0)4-HS627- (C6)2 |
undisclosed |
Undisclosed |
Undisclosed |
[60] | |
HS627- (C7)2 |
undisclosed |
Undisclosed |
Undisclosed |
[60] | |
HS627- (C7)4 |
undisclosed |
Undisclosed |
Undisclosed |
[60] | |
(C6)4-HS627- (C7)2 |
undisclosed |
Undisclosed |
Undisclosed |
[60] | |
HS627- (C8)2 |
undisclosed |
Undisclosed |
Undisclosed |
[60] | |
HS627- (C8)4 |
undisclosed |
Undisclosed |
Undisclosed |
[60] | |
(C0)4-HS627- (C8)2 |
undisclosed |
Undisclosed |
Undisclosed |
[60] |
hSD5
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
hSD5-vedotin |
Monomethyl auristatin E |
Microtubule (MT) |
Mc-Val-Cit-PABC |
[61] |
hu4DFabv7
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
hu4DFabv7-BMPEO-DM1 |
Maytansinoid DM1 |
Microtubule (MT) |
hu4DFabv7-BMPEO-DM1 linker |
[14] |
hu4DFabv8 (A121C)
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
hu4DFabv8 (A121C)-BMPEO-DM1 |
Maytansinoid DM1 |
Microtubule (MT) |
hu4DFabv8 (A121C)-BMPEO-DM1 linker |
[14] |
hu4DFabv8 (H-A175C)
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
hu4DFabv8 (H-A175C)-BMPEO-DM1 |
Maytansinoid DM1 |
Microtubule (MT) |
hu4DFabv8 (H-A175C)-BMPEO-DM1 linker |
[14] |
hu4DFabv8 (H-A40C)
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
hu4DFabv8 (H-A40C)-BMPEO-DM1 |
Maytansinoid DM1 |
Microtubule (MT) |
hu4DFabv8 (H-A40C)-BMPEO-DM1 linker |
[14] |
hu4DFabv8 (H-A88C)
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
hu4DFabv8 (H-A88C)-BMPEO-DM1 |
Maytansinoid DM1 |
Microtubule (MT) |
hu4DFabv8 (H-A88C)-BMPEO-DM1 linker |
[14] |
hu4DFabv8 (H-S119C)
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
hu4DFabv8 (H-S119C)-BMPEO-DM1 |
Maytansinoid DM1 |
Microtubule (MT) |
hu4DFabv8 (H-S119C)-BMPEO-DM1 linker |
[14] |
hu4DFabv8 (H-S122C)
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
hu4DFabv8 (H-S122C)-BMPEO-DM1 |
Maytansinoid DM1 |
Microtubule (MT) |
hu4DFabv8 (H-S122C)-BMPEO-DM1 linker |
[14] |
hu4DFabv8 (H-S179C)
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
hu4DFabv8 (H-S179C)-BMPEO-DM1 |
Maytansinoid DM1 |
Microtubule (MT) |
hu4DFabv8 (H-S179C)-BMPEO-DM1 linker |
[14] |
hu4DFabv8 (L-A144C)
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
hu4DFabv8 (L-A144C)-BMPEO-DM1 |
Maytansinoid DM1 |
Microtubule (MT) |
hu4DFabv8 (L-A144C)-BMPEO-DM1 linker |
[14] |
hu4DFabv8 (L-A43C)
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
hu4DFabv8 (L-A43C)-BMPEO-DM1 |
Maytansinoid DM1 |
Microtubule (MT) |
hu4DFabv8 (L-A43C)-BMPEO-DM1 linker |
[14] |
hu4DFabv8 (L-S168C)
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
hu4DFabv8 (L-S168C)-BMPEO-DM1 |
Maytansinoid DM1 |
Microtubule (MT) |
hu4DFabv8 (L-S168C)-BMPEO-DM1 linker |
[14] |
hu4DFabv8 (L-V15C)
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
hu4DFabv8 (L-V15C)-BMPEO-DM1 |
Maytansinoid DM1 |
Microtubule (MT) |
hu4DFabv8 (L-V15C)-BMPEO-DM1 linker |
[14] |
hu4DFabv8 (V110C)
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
hu4DFabv8 (V110C)-BMPEO-DM1 |
Maytansinoid DM1 |
Microtubule (MT) |
hu4DFabv8 (V110C)-BMPEO-DM1 linker |
[14] | |
hu4DFabv8 (V110C)-MC-MMAF |
Monomethyl auristatin F |
Microtubule (MT) |
Maleimido-caproyl |
[14] | |
hu4DFabv8 (V110C)-MC-MMAE |
Monomethyl auristatin E |
Microtubule (MT) |
Maleimido-caproyl |
[14] | |
hu4DFabv8 (V110C)-MC-Val-Cit-PAB-MMAF |
Monomethyl auristatin F |
Microtubule (MT) |
Mc-Val-Cit-PABC |
[14] | |
hu4DFabv8 (V110C)-MC-Val-Cit-PAB-MMAE |
Monomethyl auristatin E |
Microtubule (MT) |
Mc-Val-Cit-PABC |
[14] |
IP140B
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
WO2024140447A1 ADC 2 |
WO2024140447A1 ADC 1 Payload |
Undisclosed |
WO2024140447A1 ADC 1 Linker |
||
WO2024140447A1 ADC 4 |
WO2024140447A1 ADC 1 Payload |
Undisclosed |
Undisclosed |
||
WO2024140447A1 ADC 6 |
WO2024140447A1 ADC 1 Payload |
Undisclosed |
WO2024140447A1 ADC 4 Linker |
||
WO2024140447A1 ADC 8 |
WO2024140447A1 ADC 1 Payload |
Undisclosed |
WO2024140447A1 ADC 7 Linker |
||
WO2024140447A1 ADC 10 |
WO2024140447A1 ADC 1 Payload |
Undisclosed |
WO2024140447A1 ADC 9 Linker |
||
WO2024140447A1 ADC 12 |
WO2024140447A1 ADC 1 Payload |
Undisclosed |
WO2024140447A1 ADC 11 Linker |
||
WO2024140447A1 ADC 14 |
WO2024140447A1 ADC 13 Payload |
Undisclosed |
WO2024140447A1 ADC 13 Linker |
||
WO2024140447A1 ADC 16 |
WO2024140447A1 ADC 13 Payload |
Undisclosed |
WO2024140447A1 ADC 15 Linker |
||
WO2024140447A1 ADC 18 |
WO2024140447A1 ADC 13 Payload |
Undisclosed |
WO2024140447A1 ADC 17 Linker |
||
WO2024140447A1 ADC 20 |
WO2024140447A1 ADC 13 Payload |
Undisclosed |
WO2024140447A1 ADC 3 Linker |
||
WO2024140447A1 ADC 22 |
WO2024140447A1 ADC 13 Payload |
Undisclosed |
WO2024140447A1 ADC 21 Linker |
||
WO2024140447A1 ADC 24 |
WO2024140447A1 ADC 13 Payload |
Undisclosed |
WO2024140447A1 ADC 23 Linker |
||
WO2024140447A1 ADC 26 |
WO2024140447A1 ADC 1 Payload |
Undisclosed |
WO2024140447A1 ADC 25 Linker |
||
WO2024140449A1 ADC2 |
WO2024140449A1+ADC1+payload |
Undisclosed |
Mc-Val-Cit |
[62] | |
WO2024140449A1 ADC4 |
WO2024140449A1+ADC1+payload |
Undisclosed |
WO2024140449A1+ADC3+Linker |
[62] | |
WO2024140449A1 ADC6 |
WO2024140449A1+ADC5+payload |
DNA topoisomerase I (TOP1) |
WO2024140449A1+ADC5+Linker |
[62] | |
WO2024140449A1 ADC8 |
WO2024140449A1+ADC5+payload |
DNA topoisomerase I (TOP1) |
WO2024140449A1+ADC7+Linker |
[62] | |
WO2024140449A1 ADC10 |
WO2024140449A1+ADC5+payload |
DNA topoisomerase I (TOP1) |
WO2024140449A1+ADC9+Linker |
[62] | |
WO2024140449A1 ADC12 |
WO2024140449A1+ADC5+payload |
DNA topoisomerase I (TOP1) |
WO2024140449A1+ADC9+Linker |
[62] | |
WO2024140449A1 ADC14 |
WO2024140449A1+ADC13+payload |
Undisclosed |
WO2024140449A1+ADC13+Linker |
[62] | |
WO2024140449A1 ADC16 |
WO2024140449A1+ADC13+payload |
Undisclosed |
WO2024140449A1+ADC13+Linker |
[62] | |
WO2024140449A1 ADC18 |
WO2024140449A1+ADC17+payload |
Undisclosed |
WO2024140449A1+ADC17+Linker |
[62] | |
WO2024140449A1 ADC20 |
WO2024140449A1+ADC19+payload |
Undisclosed |
WO2024140449A1+ADC19+Linker |
[62] | |
WO2024140449A1 ADC22 |
WO2024140449A1+ADC5+payload |
DNA topoisomerase I (TOP1) |
WO2024140449A1+ADC5+Linker |
[62] | |
WO2024140450A1 7-[N- (IP140B-mc-Gly-Gly-Phe-Gly-ha-Ac), N- (S)-methoxyisopropyl]aminomethyl-10,11-methylenedioxycamptothecin |
Undisclosed |
Undisclosed |
Undisclosed |
[57] | |
WO2024140450A1 7-[N- (1P140B-Ac-PEG2-Val-Ala-PABC), N- (S)-methylisopropyl]aminoethyl-10,11-methylenedioxycamptothecin |
Undisclosed |
Undisclosed |
Undisclosed |
[57] | |
WO2024140450A1 7-[N- (IP140B-Ac-PEG2-Gly-Gly-Leu-Gly-ha-Ac), N- (S)-methylisopropyl]aminoethyl-10,11-methylenedi-10,11-ethenyl-10,11-dihydroxycamptothecin |
Undisclosed |
Undisclosed |
Undisclosed |
[57] | |
WO2024140450A1 7-[N- (IP140B-Ac-PEG2-Val-Ala-PABC), N-methoxyethyl]aminoethyl-10,11-methylenedi-6,7-dihydroxystilbene |
Undisclosed |
Undisclosed |
Undisclosed |
[57] | |
WO2024140450A1 7-[N- (IP140B-Ac-PEG2-Gly-Gly-Leu-Gly-ha-Ac), N-methoxyethyl]aminoethyl-10,11-methylenedi-6,7-ethenidinocamptothecin |
Undisclosed |
Undisclosed |
Undisclosed |
[57] | |
WO2024140450A1 7-[N- (IP140B-Ac-PEGz-Gly-Gly-Lys-Gly-ha-Ac), N- (S)-methylisopropyl]aminoethyl-10,11-methylenedi-10,11-ethenylhyerocytosine |
Undisclosed |
Undisclosed |
Undisclosed |
[57] | |
WO2024140450A1 7-[N- (HS627-Ac-PEG2-Gly-Lys-PABC), N- (S)-methylisopropyl]aminoethyl-10,11-methylenedi-10,11-ethenylhydragranin 4.6 |
Undisclosed |
Undisclosed |
Undisclosed |
[57] | |
IP140B ADC1 |
Undisclosed |
Undisclosed |
Undisclosed |
[58] | |
IP140B ADC2 |
Undisclosed |
Undisclosed |
Undisclosed |
[58] | |
IP140B ADC3 |
Undisclosed |
Undisclosed |
Undisclosed |
[58] | |
CN117159739A ADC1 |
undisclosed |
Undisclosed |
Undisclosed |
[63] | |
CN117159739A ADC2 |
undisclosed |
Undisclosed |
Undisclosed |
[63] | |
CN117159739A ADC5 |
undisclosed |
Undisclosed |
Undisclosed |
[63] |
Isoprenylated trastuzumab
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
LCB-ADC3 |
Monomethyl auristatin F |
Microtubule (MT) |
Bridged PEG4-valine-alanine |
[64] | |
LCB-ADC2 |
Monomethyl auristatin F |
Microtubule (MT) |
Isoprene-PEG3,3,3-beta-Glu-PABC |
[64] | |
LCB-ADC1 |
Monomethyl auristatin F |
Microtubule (MT) |
Isoprene-PEG3-beta-Glu-PABC |
[64] |
LOL1-HER2 (L234A, L235A, L328C)
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
LOL1-anti-HER2 Ab (L234A, L235A, L328C) |
Monomethyl auristatin E |
Microtubule (MT) |
Mc-Val-Cit-PABC |
[52] |
M30-H1-L4P
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
WO2022099762A1 ADCa |
Camptothecin |
DNA topoisomerase 1 (TOP1) |
WO2022099762A1 10 |
[65] | |
WO2022099762A1 ADCb |
Camptothecin |
DNA topoisomerase 1 (TOP1) |
Mc-Gly-Gly-Phe-Gly |
[65] |
mAb-1
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
IN202417103839A ADC-1 |
Undisclosed |
Undisclosed |
Undisclosed |
[66] |
mAb-2
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
IN202417103839A ADC-2 |
Undisclosed |
Undisclosed |
Undisclosed |
[66] | |
IN202417103839A ADC-3 |
Undisclosed |
Undisclosed |
Undisclosed |
[66] | |
IN202417103839A ADC-4 |
Undisclosed |
Undisclosed |
Undisclosed |
[66] | |
IN202417103839A ADC-5 |
Undisclosed |
Undisclosed |
Undisclosed |
[66] |
mAb-3
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
IN202417103839A ADC-6 |
Undisclosed |
Undisclosed |
Undisclosed |
[66] |
mAb-A
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
WO2024140927A1-ADC-A (DAR4) |
Monomethyl auristatin E |
Microtubule (MT) |
Mc-Val-Cit-PABC |
[67] | |
WO2024140927A1-ADC-D (DAR6) |
Active metabolite of irinotecan SN38 |
DNA topoisomerase 1 (TOP1) |
CL2A |
[67] | |
WO2024140927A1-ADC-D (DAR2) |
Active metabolite of irinotecan SN38 |
DNA topoisomerase 1 (TOP1) |
CL2A |
[67] | |
WO2024140927A1-ADC-E (DAR6) |
Doxorubicin |
DNA topoisomerase 2-alpha (TOP2A) |
Succinimidyl-4- (N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC) |
[67] | |
WO2024140927A1-ADC-E (DAR2) |
Doxorubicin |
DNA topoisomerase 2-alpha (TOP2A) |
Succinimidyl-4- (N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC) |
[67] | |
WO2024140927A1-ADC-A (DAR6) |
Monomethyl auristatin E |
Microtubule (MT) |
Mc-Val-Cit-PABC |
[67] | |
WO2024140927A1-ADC-A (DAR2) |
Monomethyl auristatin E |
Microtubule (MT) |
Mc-Val-Cit-PABC |
[67] |
mAb1
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
mAb1-mc-vc-PAB-MMAE |
Monomethyl auristatin E |
Microtubule (MT) |
Mc-Val-Cit-PABC |
[44] | |
mAb1-MMAE |
Monomethyl auristatin E |
Microtubule (MT) |
Mc-Val-Cit-PABC |
[68] | |
mAb1-MMAF |
Monomethyl auristatin F |
Microtubule (MT) |
Mc-Val-Cit-PABC |
[68] | |
mAb1-DXd |
DX-8951 derivative (DXd) |
DNA topoisomerase 1 (TOP1) |
Mc-Gly-Gly-Phe-Gly |
[68] | |
mAb1-Extecan |
Exatecan |
DNA topoisomerase 1 (TOP1) |
Mc-Gly-Gly-Phe-Gly |
[68] | |
mAb1-DAR6-PB |
Undisclosed |
Undisclosed |
Undisclosed |
[68] | |
mAb1-DAR6-HEPES |
Undisclosed |
Undisclosed |
Undisclosed |
[68] | |
mAb1-DAR6-MES |
Undisclosed |
Undisclosed |
Undisclosed |
[68] | |
mAb1-DAR6-Tris |
Undisclosed |
Undisclosed |
Undisclosed |
[68] | |
mAb1-DAR6-MOPSO |
Undisclosed |
Undisclosed |
Undisclosed |
[68] | |
mAb17-DM21 |
Undisclosed |
Undisclosed |
Undisclosed |
[68] | |
mAb1-MMAF+MMAE |
Undisclosed |
Undisclosed |
Undisclosed |
[68] | |
mAb1-MMAE+MMAF |
Undisclosed |
Undisclosed |
Undisclosed |
[68] | |
mAb1-MMAE+DXd |
Undisclosed |
Undisclosed |
Undisclosed |
[68] | |
mAb1-DXd+MMAE |
Undisclosed |
Undisclosed |
Undisclosed |
[68] | |
mAb1-DXd+MMAE+MMAF |
Undisclosed |
Undisclosed |
Undisclosed |
[68] | |
mAb1-MMAE+GGFG-DXd |
Undisclosed |
Undisclosed |
Undisclosed |
[68] | |
MAb1-DAR6-HEPES-20mM |
Undisclosed |
Undisclosed |
Undisclosed |
[68] | |
MAb1-DAR6-HEPES-40mM |
Undisclosed |
Undisclosed |
Undisclosed |
[68] | |
MAb1-DAR6-HEPES-60mM |
Undisclosed |
Undisclosed |
Undisclosed |
[68] | |
MAb1-DAR6-HEPES-80mM |
Undisclosed |
Undisclosed |
Undisclosed |
[68] | |
mAb1-DAR6-1mg·mL-1 |
Undisclosed |
Undisclosed |
Undisclosed |
[68] | |
mAb1-DAR6-2.5mg·mL-1 |
Undisclosed |
Undisclosed |
Undisclosed |
[68] | |
mAb1-DAR6-5mg·mL-1 |
Undisclosed |
Undisclosed |
Undisclosed |
[68] | |
mAb1-DAR6-10mg·mI-1 |
Undisclosed |
Undisclosed |
Undisclosed |
[68] | |
mAb1-DAR6-15mg·mL-1 |
Undisclosed |
Undisclosed |
Undisclosed |
[68] | |
mAb1-DAR6-20mg·mL-1 |
Undisclosed |
Undisclosed |
Undisclosed |
[68] | |
mAb1-DAR6-4°C/10.00 TCEP |
Undisclosed |
Undisclosed |
Undisclosed |
[68] | |
mAb1-DAR6-4°C/12.00 TCEP |
Undisclosed |
Undisclosed |
Undisclosed |
[68] | |
mAb1-DAR6-4°C/14.00 TCEP |
Undisclosed |
Undisclosed |
Undisclosed |
[68] | |
mAb1-DAR6-12°C/3.25 TCEP |
Undisclosed |
Undisclosed |
Undisclosed |
[68] | |
mAb1-DAR6-12°C/3.75 TCEP |
Undisclosed |
Undisclosed |
Undisclosed |
[68] | |
mAb1-DAR6-16°C/3.00 TCEP |
Undisclosed |
Undisclosed |
Undisclosed |
[68] | |
mAb1-DAR6-16°C/3.25 TCEP |
Undisclosed |
Undisclosed |
Undisclosed |
[68] | |
mAb1-DAR6-22°C/2.85 TCEP |
Undisclosed |
Undisclosed |
Undisclosed |
[68] | |
mAb1-DAR6-22°C/3.00 TCEP |
Undisclosed |
Undisclosed |
Undisclosed |
[68] | |
mAb1-DAR6-pH 6.8 |
Undisclosed |
Undisclosed |
Undisclosed |
[68] | |
mAb1-DAR6-pH 7.0 |
Undisclosed |
Undisclosed |
Undisclosed |
[68] | |
mAb1-DAR6-pH 7.4 |
Undisclosed |
Undisclosed |
Undisclosed |
[68] | |
mAb1-DAR6-pH 8.0 |
Undisclosed |
Undisclosed |
Undisclosed |
[68] | |
mAb1-Tween 20 |
Undisclosed |
Undisclosed |
Undisclosed |
[68] | |
mAb1-Benzyl Alcohol |
Undisclosed |
Undisclosed |
Undisclosed |
[68] | |
mAb1-Trehalose |
Undisclosed |
Undisclosed |
Undisclosed |
[68] | |
mAb1-Extecan+MMAE |
Undisclosed |
Undisclosed |
Undisclosed |
[68] | |
mAb1-DBM-MMAF |
Undisclosed |
Undisclosed |
Undisclosed |
[68] | |
mAb1-STB-MMAE |
Undisclosed |
Undisclosed |
Undisclosed |
[68] | |
mAb1-Bimaleimide-MMAE |
Undisclosed |
Undisclosed |
Undisclosed |
[68] | |
WO2024118785A3 Lot2 |
Undisclosed |
Undisclosed |
Undisclosed |
[69] | |
WO2024118785A3 Lot3 |
Undisclosed |
Undisclosed |
Undisclosed |
[69] | |
WO2024118785A3 Lot5 |
Undisclosed |
Undisclosed |
Undisclosed |
[69] | |
WO2024118785A3 Lot7 |
Undisclosed |
Undisclosed |
Undisclosed |
[69] | |
WO2024118785A3 Lot10 |
Undisclosed |
Undisclosed |
Undisclosed |
[69] | |
WO2024118785A3 Lot14 |
Undisclosed |
Undisclosed |
Undisclosed |
[69] | |
WO2024118785A3 Lot18 |
Undisclosed |
Undisclosed |
Undisclosed |
[69] | |
WO2024118785A3 Lot20 |
Undisclosed |
Undisclosed |
Undisclosed |
[69] | |
WO2024118785A3 Lot21 |
Undisclosed |
Undisclosed |
Undisclosed |
[69] | |
WO2024118785A3 Lot43 |
Undisclosed |
Undisclosed |
Undisclosed |
[69] | |
WO2024118785A3 Lot48 |
Undisclosed |
Undisclosed |
Undisclosed |
[69] | |
WO2024118785A3 Lot52 |
Undisclosed |
Undisclosed |
Undisclosed |
[69] | |
Ab-AL-LP2 |
Pro-DHT |
Undisclosed |
DIBAC-PEG4-vcPAB |
[70] | |
Ab-AL-LP3 |
Pro-DHT |
Undisclosed |
DIBAC-PEG4-EvcPAB linker |
[70] | |
Ab-AL-LP7 |
Pro-DHT |
Undisclosed |
COT-PEG4-branch-PEG2-EvcPAB |
[70] | |
Ab-AL-LP41 |
DHT |
Undisclosed |
COT-PEG4-VK-PABC |
[70] | |
Ab-BL-LP7 |
Pro-DHT |
Undisclosed |
COT-PEG4-branch-PEG2-EvcPAB |
[70] | |
Ab-LP3A |
Pro-DHT |
Undisclosed |
NH2-PEG4-EvcPAB |
[70] | |
Ab-LP5A |
DHT |
Undisclosed |
NH2-PEG4-EvcPAB-NHCH2 |
[70] | |
Ab-LP44 |
DHT |
Undisclosed |
NH2-PEG4-vcPABC |
[70] | |
Ab-LP33 |
Pro-DHT |
Undisclosed |
Mc-PEG4-EvcPAB |
[70] |
Margetuximab
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
Margetuximab-ADC-Tb3-1 |
Margetuximab-ADC-Tb3-1 payload |
Undisclosed |
Margetuximab-ADC-Tb3-1 linker |
[7] | |
Margetuximab-ADC-Tb3-2 |
Margetuximab-ADC-Tb3-2 payload |
Undisclosed |
Margetuximab-ADC-Tb3-2 linker |
[7] | |
Margetuximab-ADC-Tb3-3 |
Margetuximab-ADC-Tb3-3 payload |
Undisclosed |
Margetuximab-ADC-Tb3-3 linker |
[7] | |
Margetuximab-ADC-Tb3-4 |
Margetuximab-ADC-Tb3-4 payload |
Undisclosed |
Margetuximab-ADC-Tb3-4 linker |
[7] | |
Margetuximab-ADC-Tb3-5 |
Margetuximab-ADC-Tb3-5 payload |
Undisclosed |
Margetuximab-ADC-Tb3-5 linker |
[7] | |
Margetuximab-ADC-Tb3-6 |
Margetuximab-ADC-Tb3-6 payload |
Undisclosed |
Margetuximab-ADC-Tb3-6 linker |
[7] | |
Margetuximab-ADC-Tb3-7 |
Margetuximab-ADC-Tb3-7 payload |
Undisclosed |
Margetuximab-ADC-Tb3-7 linker |
[7] | |
Margetuximab-ADC-Tb3-8 |
Margetuximab-ADC-Tb3-8 payload |
Undisclosed |
Margetuximab-ADC-Tb3-8 linker |
[7] | |
Margetuximab-ADC-Tb3-9 |
Margetuximab-ADC-Tb3-9 payload |
Undisclosed |
Margetuximab-ADC-Tb3-9 linker |
[7] | |
Margetuximab-ADC-Tb3-10 |
Margetuximab-ADC-Tb3-10 payload |
Undisclosed |
Margetuximab-ADC-Tb3-10 linker |
[7] | |
EP4487874A1-1 |
EP4487874A1-1payload |
Undisclosed |
EP4487874A1-1linker |
[71] | |
EP4487874A1-4 |
EP4487874A1-4payload |
Undisclosed |
EP4487874A1-3linker |
[71] |
mi140
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
CN114605367B A-II-11C |
Undisclosed |
Undisclosed |
Undisclosed |
[72] | |
CN114605367B A-II-12C |
A-II-12C Payload |
Undisclosed |
6-Maleimidocaproic acid |
[72] | |
CN114605367B A-II-13C |
A-II-13C Payload |
Undisclosed |
6-Maleimidocaproic acid |
[72] | |
CN114605367B A-II-14C |
A-II-14C Payload |
Undisclosed |
6-Maleimidocaproic acid |
[72] | |
CN114605367B A-II-21-C |
Undisclosed |
Undisclosed |
Undisclosed |
[72] | |
CN114605367B A-II-22-C |
A-II-22-C Payload |
Undisclosed |
6-Maleimidocaproic acid |
[72] | |
CN114605367B A-II-23-C |
A-II-23-C Payload |
Undisclosed |
6-Maleimidocaproic acid |
[72] | |
CN114605367B A-II-24-C |
A-II-24-C Payload |
Undisclosed |
6-Maleimidocaproic acid |
[72] | |
CN114605367B A-III-11 |
Undisclosed |
Undisclosed |
Undisclosed |
[72] | |
CN114605367B A-III-12 |
A-III-12 Payload |
Undisclosed |
6-Maleimidocaproic acid |
[72] | |
CN114605367B A-III-13 |
A-III-13 Payload |
Undisclosed |
6-Maleimidocaproic acid |
[72] | |
CN114605367B A-III-14 |
A-III-14 Payload |
Undisclosed |
6-Maleimidocaproic acid |
[72] | |
CN114605367B A-III-21 |
Undisclosed |
Undisclosed |
Undisclosed |
[72] | |
CN114605367B A-III-22 |
A-III-22 Payload |
Undisclosed |
6-Maleimidocaproic acid |
[72] | |
CN114605367B A-III-23 |
A-III-23 Payload |
Undisclosed |
6-Maleimidocaproic acid |
[72] | |
CN114605367B A-III-24 |
A-III-24 Payload |
Undisclosed |
6-Maleimidocaproic acid |
[72] | |
CN114605367B IV-21 |
Undisclosed |
Undisclosed |
Undisclosed |
[72] | |
CN114605367B IV-22 |
A-III-22 Payload |
Undisclosed |
6-Maleimidocaproic acid |
[72] | |
CN114605367B IV-23 |
A-III-23 Payload |
Undisclosed |
6-Maleimidocaproic acid |
[72] | |
CN114605367B IV-24 |
A-III-24 Payload |
Undisclosed |
6-Maleimidocaproic acid |
[72] | |
CN114605367B IV-11 |
Undisclosed |
Undisclosed |
Undisclosed |
[72] | |
CN114605367B IV-12 |
A-III-12 Payload |
Undisclosed |
6-Maleimidocaproic acid |
[72] | |
CN114605367B IV-13 |
A-III-13 Payload |
Undisclosed |
6-Maleimidocaproic acid |
[72] | |
CN114605367B IV-14 |
A-III-14 Payload |
Undisclosed |
6-Maleimidocaproic acid |
[72] |
Mil40
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
Mil40-12B |
Monomethyl auristatin E |
Microtubule (MT) |
Maleamic methyl ester-based linker 12B |
[73] | |
Mil40-12B |
Monomethyl auristatin E |
Microtubule (MT) |
Mc-Val-Cit-PABC |
[73] | |
Mil40-5 |
Active metabolite of irinotecan SN38 |
DNA topoisomerase 1 (TOP1) |
Mc-Val-Ala-PABC |
[74] | |
Mil40-6 |
Active metabolite of irinotecan SN38 |
DNA topoisomerase 1 (TOP1) |
Mal-PEG2-Val-Ala-PABC |
[74] | |
Mil40-7 |
Active metabolite of irinotecan SN38 |
DNA topoisomerase 1 (TOP1) |
Mal-PEG4-Val-Ala-PABC |
[74] | |
Mil40-8 |
Active metabolite of irinotecan SN38 |
DNA topoisomerase 1 (TOP1) |
Mal-PEG8-Val-Ala-PABC |
[74] | |
Mil40-12A |
Monomethyl auristatin E |
Microtubule (MT) |
Maleamic methyl ester-based linker 12A |
[73] | |
Mil40-12C |
Monomethyl auristatin E |
Microtubule (MT) |
Maleamic methyl ester-based linker 12C |
[73] | |
Mil40-11 (DAR=7.1) |
Active metabolite of irinotecan SN38 |
DNA topoisomerase 1 (TOP1) |
Mc-PEG8-Val-Ala-PABC |
[74] | |
Mil40-11 (DAR=3.8) |
Active metabolite of irinotecan SN38 |
DNA topoisomerase 1 (TOP1) |
Mc-PEG8-Val-Ala-PABC |
[74] | |
Cys-linker-MMAE-based ADC 11 |
Monomethyl auristatin E |
Microtubule (MT) |
Cys-11 ADC linker |
[75] | |
Cys-linker-MMAE-based ADC 12 |
Monomethyl auristatin E |
Microtubule (MT) |
Cys-12 ADC linker |
[75] | |
Cys-linker-MMAE-based ADC 13 |
Monomethyl auristatin E |
Microtubule (MT) |
Cys-13 ADC linker |
[75] | |
Cys-linker-MMAE-based ADC 14 |
Monomethyl auristatin E |
Microtubule (MT) |
Cys-14 ADC linker |
[75] | |
Cys-linker-MMAE-based ADC 15 |
Monomethyl auristatin E |
Microtubule (MT) |
Mc-PABC |
[75] | |
Cys-linker-MMAE-based ADC 16 |
Monomethyl auristatin E |
Microtubule (MT) |
Mc-Val-Cit-PABC |
[75] | |
ADC Mil40-6 |
Monomethyl auristatin E |
Microtubule (MT) |
Silyl ether-based linker |
[76] | |
Mil40-15 |
Monomethyl auristatin E |
Microtubule (MT) |
Mc-PABC |
[75] | |
Trastuzumab biosimilar mil40 12a |
Monomethyl auristatin E |
Microtubule (MT) |
Maleamic methyl ester-based Val-Ala-PABC linker 12a |
[77] | |
Trastuzumab biosimilar mil40 12b |
Monomethyl auristatin E |
Microtubule (MT) |
Maleamic methyl ester-based Val-Ala-PABC linker 12b |
[77] | |
Trastuzumab biosimilar mil40 12c |
Monomethyl auristatin E |
Microtubule (MT) |
Maleamic methyl ester-based Val-Cit-PABC linker 12c |
[77] |
mil40
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
EP3838893B1-ADC-I |
Monomethyl auristatin E |
Microtubule (MT) |
Mm-C3-Val-Ala-PAB |
[78] | |
EP3838893B1-ADC-II |
Monomethyl auristatin E |
Microtubule (MT) |
Mm-C6-Val-Ala-PAB |
[78] | |
EP3838893B1-ADC-III |
Monomethyl auristatin E |
Microtubule (MT) |
Mm-C6-Val-Cit-PAB |
[78] | |
EP3838893B1-ADC-IV |
Undisclosed |
Undisclosed |
Mm-C6-Val-Cit-PAB |
[78] | |
EP3838893B1-ADC-A |
Monomethyl auristatin E |
Microtubule (MT) |
Mm-C6-PEG4-Val-Ala-PAB |
[78] | |
EP3838893B1-ADC-B |
Monomethyl auristatin E |
Microtubule (MT) |
Mm-C6-PEG8-Val-Ala-PAB |
[78] | |
EP3838893B1-ADC-C |
Monomethyl auristatin E |
Microtubule (MT) |
Mm-C6-PEG8'-Val-Ala-PAB |
[78] | |
Su-C6-Val-Cit-PAB |
Monomethyl auristatin E |
Microtubule (MT) |
Mc-Val-Cit-PABC |
[78] | |
Mm-C6-PEG4-Val-Ala-PAB-MMAE |
Monomethyl auristatin E |
Microtubule (MT) |
Mm-C6-PEG4-Val-Ala-PAB |
[78] | |
Mm-C6-PEG8-Val-Ala-PAB-MMAE |
Monomethyl auristatin E |
Microtubule (MT) |
Mm-C6-PEG8-Val-Ala-PAB |
[78] | |
Mm-C6-PEG8'-Val-Ala-PAB-MMAE |
Monomethyl auristatin E |
Microtubule (MT) |
Mm-C6-PEG8'-Val-Ala-PAB |
[78] | |
Su-C3-VA |
Monomethyl auristatin E |
Microtubule (MT) |
PEG2-Val-Cit-PABC |
[78] | |
Su-C6-VC |
Monomethyl auristatin E |
Microtubule (MT) |
Mc-Val-Cit-PABC |
[78] | |
Su-C6-VA |
Monomethyl auristatin E |
Microtubule (MT) |
Mc-Val-Ala-PABC |
[78] |
Minibody (4 cys)
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
Mb (4)-m- (b-PEG12)-VC-MMAE |
Monomethyl auristatin E |
Microtubule (MT) |
IgG (8)-m- (b-PEG12)-VC-MMAE |
[79] |
Modified ZHER2:2891 protein (ZHER2)
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
Pyro-Linker-ZHER2 |
Pyropheophorbide-a |
Undisclosed |
Pyro-Linker based linker |
[80] |
mouse anti-human HER2 Ab
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
WO2023232144A1ADC34 |
WO2025015586A1, ADC34, Payload |
Toll-like receptor 7 (TLR7); Toll-like receptor 8 (TLR8) |
Mc-Val-Cit-PABC |
[81] | |
WO2023232144A1ADC35 |
WO2025015586A1, ADC35, Payload |
Toll-like receptor 7 (TLR7); Toll-like receptor 8 (TLR8) |
Mc-Val-Cit-PABC |
[81] | |
WO2023232144A1ADC36 |
WO2025015586A1, ADC34, Payload |
Toll-like receptor 7 (TLR7); Toll-like receptor 8 (TLR8) |
SMCC |
[81] | |
WO2023232144A1ADC37 |
WO2025015586A1, ADC35, Payload |
Toll-like receptor 7 (TLR7); Toll-like receptor 8 (TLR8) |
SMCC |
[81] |
NOV0712
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
NOV0712-Dxd |
DX-8951 derivative (DXd) |
DNA topoisomerase 1 (TOP1) |
Mc-Gly-Gly-Phe-Gly |
[51] |
Palivizumab_msIgG2a
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
Palivizumab_msIgG2a Conjugate 3 |
Undisclosed |
Undisclosed |
Undisclosed |
[4] |
Patritumab
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
WO2022228495A1 ADC-72 |
WO2022228495A1 ADC-72 payload |
Undisclosed |
WO2022228495A1 ADC-72 linker |
[50] |
Pertuzumab
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
WO2020063676A1 ADC-7 |
WO2020063676A1_ADC-7 payload |
Undisclosed |
WO2020063676A1_ADC-7 linker |
[82] | |
WO2020063676A1 ADC-8 |
WO2020063676A1_ADC-8 payload |
Undisclosed |
WO2020063676A1_ADC-8 linker |
[82] | |
WO2020063676A1 ADC-9 |
WO2020063676A1_ADC-9 payload |
Undisclosed |
WO2020063676A1_ADC-9 linker |
[82] | |
Pertuzumab-ADC-Tb3-1 |
Pertuzumab-ADC-Tb3-1 payload |
Undisclosed |
Pertuzumab-ADC-Tb3-1 linker |
[7] | |
Pertuzumab-ADC-Tb3-2 |
Pertuzumab-ADC-Tb3-2 payload |
Undisclosed |
Pertuzumab-ADC-Tb3-2 linker |
[7] | |
Pertuzumab-ADC-Tb3-3 |
Pertuzumab-ADC-Tb3-3 payload |
Undisclosed |
Pertuzumab-ADC-Tb3-3 linker |
[7] | |
Pertuzumab-ADC-Tb3-4 |
Pertuzumab-ADC-Tb3-4 payload |
Undisclosed |
Pertuzumab-ADC-Tb3-4 linker |
[7] | |
Pertuzumab-ADC-Tb3-5 |
Pertuzumab-ADC-Tb3-5 payload |
Undisclosed |
Pertuzumab-ADC-Tb3-5 linker |
[7] | |
Pertuzumab-ADC-Tb3-6 |
Pertuzumab-ADC-Tb3-6 payload |
Undisclosed |
Pertuzumab-ADC-Tb3-6 linker |
[7] | |
Pertuzumab-ADC-Tb3-7 |
Pertuzumab-ADC-Tb3-7 payload |
Undisclosed |
Pertuzumab-ADC-Tb3-7 linker |
[7] | |
Pertuzumab-ADC-Tb3-8 |
Pertuzumab-ADC-Tb3-8 payload |
Undisclosed |
Pertuzumab-ADC-Tb3-8 linker |
[7] | |
Pertuzumab-ADC-Tb3-9 |
Pertuzumab-ADC-Tb3-9 payload |
Undisclosed |
Pertuzumab-ADC-Tb3-9 linker |
[7] | |
Pertuzumab-ADC-Tb3-10 |
Pertuzumab-ADC-Tb3-10 payload |
Undisclosed |
Pertuzumab-ADC-Tb3-10 linker |
[7] | |
Pertuzumab-Compound(la) |
NeoDegrader P1 |
Protein cereblon (CRBN) |
Pertuzumab-Compound(la) linker |
[83] | |
Pertuzumab-Compound (la) DAR 8 |
NeoDegrader P1 |
Protein cereblon (CRBN) |
Pertuzumab-Compound (la) DAR 8 linker |
[83] | |
Pertuzumab-Compound(lc) |
NeoDegrader P4 |
Protein cereblon (CRBN) |
Pertuzumab-Compound(lc) linker |
[83] | |
Pertuzumab-Compound (lc) DAR 8 |
NeoDegrader P4 |
Protein cereblon (CRBN) |
Pertuzumab-Compound (lc) DAR 8 linker |
[83] | |
Pertuzumab-Compound (le) |
NeoDegrader P1 |
Protein cereblon (CRBN) |
Pertuzumab-Compound (le) linker |
[83] | |
Pertuzumab-Compound (lf) |
NeoDegrader P6 |
Protein cereblon (CRBN) |
Pertuzumab-Compound (lf) linker |
[83] | |
Pertuzumab-Compound (lg) |
NeoDegrader P2 |
Protein cereblon (CRBN) |
Pertuzumab-Compound (lg) linker |
[83] | |
Pertuzumab-Compound (lh) |
NeoDegrader P13 |
Protein cereblon (CRBN) |
Pertuzumab-Compound (lh) linker |
[83] | |
Pertuzumab-Compound (li) |
NeoDegrader P1 |
Protein cereblon (CRBN) |
Pertuzumab-Compound (li) linker |
[83] | |
Pertuzumab-Compound (lj) |
NeoDegrader P1 |
Protein cereblon (CRBN) |
Pertuzumab-Compound (lj) linker |
[83] | |
Pertuzumab-Compound (lk) |
NeoDegrader P14 |
Protein cereblon (CRBN) |
Pertuzumab-Compound (lk) linker |
[83] | |
Pertuzumab-Compound (ll) |
NeoDegrader P14 |
Protein cereblon (CRBN) |
Pertuzumab-Compound (ll) linker |
[83] | |
Pertuzumab-Compound (lm) |
NeoDegrader P14 |
Protein cereblon (CRBN) |
Pertuzumab-Compound (lm) linker |
[83] | |
Pertuzumab-Compound (X) |
Pertuzumab-Compound (X) payload |
Undisclosed |
Pertuzumab-Compound (X) linker |
[53] | |
Pertuzumab-Compound (XI) |
Pertuzumab-Compound (XI) payload |
Undisclosed |
Pertuzumab-Compound (XI) linker |
[53] | |
Pertuzumab-Compound (XIV) |
Pertuzumab-Compound (XIV) payload |
Undisclosed |
Pertuzumab-Compound (XIV) linker |
[53] | |
Pertuzumab-Compound (XVIII) |
Pertuzumab-Compound (XVIII) payload |
Undisclosed |
Pertuzumab-Compound (XVIII) linker |
[53] | |
Pertuzumab-Compound (Ie) |
Pertuzumab-Compound (Ie) payload |
Undisclosed |
Pertuzumab-Compound (Ie) linker |
[53] | |
Pertuzumab-Compound (XIX) |
Pertuzumab-Compound (XIX) payload |
Undisclosed |
Pertuzumab-Compound (XIX) linker |
[53] | |
Pertuzumab-Compound (Ii) |
Pertuzumab-Compound (Ii) payload |
Undisclosed |
Pertuzumab-Compound (Ii) linker |
[53] | |
Pertuzumab-Compound (XLI) |
Pertuzumab-Compound (XLI) payload |
Undisclosed |
Pertuzumab-Compound (XLI) linker |
[53] | |
Pertuzumab-Compound (XVI) |
Pertuzumab-Compound (XIX) payload |
Undisclosed |
Pertuzumab-Compound (XIX) linker |
[53] | |
Pertuzumab-Compound (XL) |
Pertuzumab-Compound (XL) payload |
Undisclosed |
Pertuzumab-Compound (XL) linker |
[53] | |
Pertuzumab-Compound (XLIII) |
Pertuzumab-Compound (XLIII) payload |
Undisclosed |
Pertuzumab-Compound (XLIII) linker |
[53] | |
Pertuzumab-Compound (XLII) |
Pertuzumab-Compound (XLII) payload |
Undisclosed |
Pertuzumab-Compound (XLII) linker |
[53] | |
Pertuzumab-Compound (XV) |
Pertuzumab-Compound (XV) payload |
Undisclosed |
Pertuzumab-Compound (XV) linker |
[53] | |
Pertuzumab-Compound 9 |
Mertansine DM1 |
Microtubule (MT) |
Pertuzumab-Compound 9 linker |
[23] | |
Pertuzumab-Compound 17 |
Mertansine DM4 |
Microtubule (MT) |
Pertuzumab-Compound 17 linker |
[23] | |
Pertuzumab-Compound 25 |
Monomethyl auristatin E |
Microtubule (MT) |
Pertuzumab-Compound 25 linker |
[23] | |
Pertuzumab-Compound 31 |
Auristatin 0101 |
Microtubule (MT) |
Pertuzumab-Compound 31 linker |
[23] | |
Pertuzumab-Compound 36 |
Monomethyl auristatin E |
Microtubule (MT) |
Pertuzumab-Compound 36 linker |
[23] | |
Pertuzumab-Compound 43 |
PBD dimer |
Human Deoxyribonucleic acid (hDNA) |
Pertuzumab-Compound 43 linker |
[23] | |
Pertuzumab-Compound 49 |
PBD dimer |
Human Deoxyribonucleic acid (hDNA) |
Pertuzumab-Compound 49 linker |
[23] | |
Pertuzumab-Compound 55 |
Mertansine DM1 |
Microtubule (MT) |
Pertuzumab-Compound 55 linker |
[23] | |
Pertuzumab-Compound 59 |
Mertansine DM4 |
Microtubule (MT) |
Pertuzumab-Compound 59 linker |
[23] | |
Pertuzumab-Compound 64 |
Monomethyl auristatin E |
Microtubule (MT) |
Pertuzumab-Compound 64 linker |
[23] | |
Pertuzumab-Compound 69 |
Monomethyl auristatin E |
Microtubule (MT) |
Pertuzumab-Compound 69 linker |
[23] | |
Pertuzumab-Compound 74 |
PBD dimer |
Human Deoxyribonucleic acid (hDNA) |
Pertuzumab-Compound 74 linker |
[23] | |
Pertuzumab-Compound 75 |
Monomethyl auristatin E |
Microtubule (MT) |
Pertuzumab-Compound 75 linker |
[23] | |
Pertuzumab-Compound 76 |
Monomethyl auristatin E |
Microtubule (MT) |
Pertuzumab-Compound 76 linker |
[23] | |
Pertuzumab-Compound 77 |
Mertansine DM1 |
Microtubule (MT) |
Pertuzumab-Compound 77 linker |
[23] | |
Pertuzumab-Compound 78 |
Auristatin 0101 |
Microtubule (MT) |
Pertuzumab-Compound 78 linker |
[23] | |
Pertuzumab-Compound 79 |
Auristatin 0101 |
Microtubule (MT) |
Pertuzumab-Compound 79 linker |
[23] | |
Pertuzumab-Compound 80 |
Mertansine DM4 |
Microtubule (MT) |
Pertuzumab-Compound 80 linker |
[23] | |
Per-2C |
Undisclosed |
Undisclosed |
Undisclosed |
[84] | |
Per-5C |
Undisclosed |
Undisclosed |
Undisclosed |
[84] | |
WO2024169913A1 ADC07-01-8 |
B19 |
Eukaryotic peptide chain release factor GTP-binding subunit ERF3A (GSPT1) |
Mc-Val-Cit-PABC |
[86] | |
WO2024169913A1 ADC07-01-4 |
B19 |
Eukaryotic peptide chain release factor GTP-binding subunit ERF3A (GSPT1) |
Mc-Val-Cit-PABC |
[86] | |
WO2024169913A1 ADC07-02-8 |
B19 |
Eukaryotic peptide chain release factor GTP-binding subunit ERF3A (GSPT1) |
Mc-Val-Ala-PABC |
[86] | |
WO2024169913A1 ADC07-02-4 |
B19 |
Eukaryotic peptide chain release factor GTP-binding subunit ERF3A (GSPT1) |
Mc-Val-Ala-PABC |
[86] | |
WO2024169913A1 ADC07-06-8 |
B63 |
Eukaryotic peptide chain release factor GTP-binding subunit ERF3A (GSPT1) |
Mc-Val-Ala-PABC |
[86] | |
WO2024169913A1 ADC07-06-4 |
B63 |
Eukaryotic peptide chain release factor GTP-binding subunit ERF3A (GSPT1) |
Mc-Val-Ala-PABC |
[86] | |
WO2024169913A1 ADC07-08-8 |
B19 |
Eukaryotic peptide chain release factor GTP-binding subunit ERF3A (GSPT1) |
(Linker-03)SMCC-TAZ-PEG-VC-PAB |
[86] | |
WO2024169913A1 ADC07-08-4 |
B19 |
Eukaryotic peptide chain release factor GTP-binding subunit ERF3A (GSPT1) |
(Linker-03)SMCC-TAZ-PEG-VC-PAB |
[86] | |
WO2024169913A1 ADC07-09-8 |
Smol006 |
Eukaryotic peptide chain release factor GTP-binding subunit ERF3A (GSPT1) |
Mc-Val-Cit-PABC |
[86] | |
WO2024169913A1 ADC07-09-4 |
Smol006 |
Eukaryotic peptide chain release factor GTP-binding subunit ERF3A (GSPT1) |
Mc-Val-Cit-PABC |
[86] |
pertuzumab
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
CN114306633A A-1 |
Monomethyl auristatin E |
Microtubule (MT) |
CN114306633A-A-1-linker |
[85] | |
CN114306633A C-3 |
Monomethyl auristatin E |
Microtubule (MT) |
CN114306633A-C-3-linker |
[85] |
Pertuzumab-S239C
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
HER2-A Antibody-Compound (X) |
HER2-A Antibody-Compound (X) payload |
Undisclosed |
HER2-A Antibody-Compound (X) linker |
[53] | |
HER2-A Antibody-Compound (XI) |
HER2-A Antibody-Compound (XI) payload |
Undisclosed |
HER2-A Antibody-Compound (XI) linker |
[53] | |
HER2-A Antibody-Compound (XIV) |
HER2-A Antibody-Compound (XIV) payload |
Undisclosed |
HER2-A Antibody-Compound (XIV) linker |
[53] | |
HER2-A Antibody-Compound (XVIII) |
HER2-A Antibody-Compound (XVIII) payload |
Undisclosed |
HER2-A Antibody-Compound (XVIII) linker |
[53] | |
HER2-A Antibody-Compound (Ie) |
HER2-A Antibody-Compound (Ie) payload |
Undisclosed |
HER2-A Antibody-Compound (Ie) linker |
[53] | |
HER2-A Antibody-Compound (XIX) |
HER2-A Antibody-Compound (XIX) payload |
Undisclosed |
HER2-A Antibody-Compound (XIX) linker |
[53] | |
HER2-A Antibody-Compound (Ii) |
HER2-A Antibody-Compound (Ii) payload |
Undisclosed |
HER2-A Antibody-Compound (Ii) linker |
[53] | |
HER2-A Antibody-Compound (XLI) |
HER2-A Antibody-Compound (XLI) payload |
Undisclosed |
HER2-A Antibody-Compound (XLI) linker |
[53] | |
HER2-A Antibody-Compound (XVI) |
HER2-A Antibody-Compound (XIX) payload |
Undisclosed |
HER2-A Antibody-Compound (XIX) linker |
[53] | |
HER2-A Antibody-Compound (XL) |
HER2-A Antibody-Compound (XL) payload |
Undisclosed |
HER2-A Antibody-Compound (XL) linker |
[53] | |
HER2-A Antibody-Compound (XLIII) |
HER2-A Antibody-Compound (XLIII) payload |
Undisclosed |
HER2-A Antibody-Compound (XLIII) linker |
[53] | |
HER2-A Antibody-Compound (XLII) |
HER2-A Antibody-Compound (XLII) payload |
Undisclosed |
HER2-A Antibody-Compound (XLII) linker |
[53] | |
Pertuzumab-S239C-Compound (XV) |
Pertuzumab-S239C-Compound (XV) payload |
Undisclosed |
Pertuzumab-S239C-Compound (XV) linker |
[53] |
Ptz-SA
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
Ptz-SA vedotin |
Monomethyl auristatin E |
Microtubule (MT) |
Mc-Val-Cit-PABC |
[87] |
Rat IgG2a mAb ICR12
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
Monoclonal antibody ICR12-CPG2 conjugate |
Carboxypeptidase G2 (CPG2) |
Undisclosed |
Undisclosed |
[88] |
RC48
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
(RC48-vc-MMAE) |
Monomethyl auristatin E |
Microtubule (MT) |
Mc-Val-Ala-PABC |
[89] |
Rituximab
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
CN119343374A ADC-RIT41C |
Undisclosed |
Undisclosed |
Undisclosed |
[90] |
S1 Trastuzumab glycovariants
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
S1 Trastuzumab glycovariants ADC |
Monomethyl auristatin E |
Microtubule (MT) |
DBCO-PEG4-Val-Cit |
[91] |
S4 Trastuzumab glycovariants
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
S4 Trastuzumab glycovariants ADC |
Monomethyl auristatin E |
Microtubule (MT) |
DBCO-PEG4-Val-Cit |
[91] |
S6 Trastuzumab glycovariants
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
S6 Trastuzumab glycovariants ADC |
Monomethyl auristatin E |
Microtubule (MT) |
DBCO-PEG4-Val-Cit |
[91] |
Sacituzumab
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
Anti-Her2- (Q295-mcValCitPABC-A6)- (mcMMAF) |
Monomethyl auristatin F |
Microtubule (MT) |
Undisclosed |
[92] | |
Anti-Her2- (0295-mcA6)- (mcMMAF) |
Monomethyl auristatin F |
Microtubule (MT) |
Undisclosed |
[92] | |
Anti-Her2- (0295-mcMMAF)- (mcValCitPABC-A6) |
Monomethyl auristatin F |
Microtubule (MT) |
Undisclosed |
[92] | |
Anti-Her2- (0295-mcMMAF)- (mc-A6) |
Monomethyl auristatin F |
Microtubule (MT) |
Undisclosed |
[92] | |
Her2-Saci- (mc-MMAF)- (McAsnAsn-A6) |
Monomethyl auristatin F |
Microtubule (MT) |
Undisclosed |
[92] | |
Her2-Saci- (mc-MMAF)- (mc-A6) |
Monomethyl auristatin F |
Microtubule (MT) |
Undisclosed |
[92] |
SCAHer2 (1)xSCAHer (2)
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
CN117337196A Compound88 |
Active metabolite of irinotecan SN38 |
DNA topoisomerase 1 (TOP1) |
30kmPEG-Lys (PEG2 - Mal)-3 (Val-Cit-PAB-DEA) |
[93] |
SCAHer2 (1)xSCAHer2
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
CN117337196A Compound86 |
Active metabolite of irinotecan SN38 |
DNA topoisomerase 1 (TOP1) |
30kmPEG-Lys (PEG2 - Mal)-2 (Val-Cit-PAB-DEA) |
[93] |
T (kK183C+K290C)
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
T (kK183C+K290C)-VC0101 ADC |
Auristatin 0101 |
Microtubule (MT) |
Mc-Val-Cit-PABC |
[94] |
TCO-trastuzumab trast-v1a-XL11
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
Trast-v1a-XL11-204 |
Undisclosed |
Undisclosed |
Undisclosed |
[41] |
Thio Anti-HER2 hu7C2 HC L177C
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
WO2017059289A1 ADC-117 |
WO2017059289A1_ADC-117 payload |
Undisclosed |
WO2017059289A1_ADC-117 linker |
[95] |
Thio Anti-HER2 hu7C2 HC Y376C
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
WO2017059289A1 ADC-119 |
WO2017059289A1_ADC-119 payload |
Undisclosed |
WO2017059289A1_ADC-119 linker |
[95] |
Thio Anti-HER2 hu7C2 LC K149C
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
WO2017059289A1 ADC-101 |
WO2017059289A1_ADC-101 payload |
Undisclosed |
WO2017059289A1_ADC-101 linker |
[95] | |
WO2017059289A1 ADC-102 |
WO2017059289A1_ADC-102 payload |
Undisclosed |
WO2017059289A1_ADC-102 linker |
[95] | |
WO2017059289A1 ADC-104 |
WO2017059289A1_ADC-104 payload |
Undisclosed |
WO2017059289A1_ADC-104 linker |
[95] | |
WO2017059289A1 ADC-106 |
WO2017059289A1_ADC-106 payload |
Undisclosed |
WO2017059289A1_ADC-106 linker |
[95] | |
WO2017059289A1 ADC-108 |
WO2017059289A1_ADC-108 payload |
Undisclosed |
WO2017059289A1_ADC-108 linker |
[95] | |
WO2017059289A1 ADC-109 |
WO2017059289A1_ADC-109 payload |
Undisclosed |
WO2017059289A1_ADC-109 linker |
[95] | |
WO2017059289A1 ADC-201 |
WO2017059289A1_ADC-201 payload |
Undisclosed |
WO2017059289A1_ADC-201 linker |
[95] | |
WO2017059289A1 ADC-203 |
WO2017059289A1_ADC-203 payload |
Undisclosed |
WO2017059289A1_ADC-203 linker |
[95] | |
WO2017059289A1 ADC-205 |
WO2017059289A1_ADC-205 payload |
Undisclosed |
WO2017059289A1_ADC-205 linker |
[95] |
Thio Anti-HER2 hu7C2 LC K149C HC L177C
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
WO2017059289A1 ADC-113 |
WO2017059289A1_ADC-113 payload |
Undisclosed |
WO2017059289A1_ADC-113 linker |
[95] |
Thio Anti-HER2 hu7C2 LC K149C HC L177C HC Y376C
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
WO2017059289A1 ADC-114 |
WO2017059289A1_ADC-114 payload |
Undisclosed |
WO2017059289A1_ADC-114 linker |
[95] |
Thio Her2 7C2 HC:A140C
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
CN118436801A PAC 5 |
undisclosed |
Undisclosed |
Mc-Val-Cit-PABC |
[96] |
Thio hu Anti-HER2 4D5-8 HC A118C
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
WO2014159981A2 ADC-211 |
WO2014159981A2_ADC-211 payload |
Undisclosed |
WO2014159981A2_ADC-211 linker |
[97] | |
WO2014159981A2 ADC-130 |
WO2014159981A2_ADC-130 payload |
Undisclosed |
WO2014159981A2_ADC-130 linker |
[97] | |
WO2014159981A2 ADC-HER2-48 |
WO2014159981A2_ADC-HER2-48 payload |
Undisclosed |
WO2014159981A2_ADC-HER2-48 linker |
[97] | |
WO2014159981A2 ADC-HER2-22 |
WO2014159981A2_ADC-HER2-22 payload |
Undisclosed |
WO2014159981A2_ADC-HER2-22 linker |
[97] |
Thio hu Anti-HER2 7C2 HC A140C
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
WO2017214024A1 ADC-106 |
WO2017214024A1_ADC-106 payload |
Undisclosed |
WO2017214024A1_ADC-106 linker |
[98] |
Thio hu Anti-HER2 7C2 LC K149C
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
WO2017214024A1 ADC-103 |
WO2017214024A1_ADC-103 payload |
Undisclosed |
WO2017214024A1_ADC-103 linker |
[98] |
Thio Hu Anti-Her2 7C2 LC K149C
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
CN118436801A PAC 1 |
undisclosed |
Undisclosed |
Mc-Val-Cit-PABC |
[96] |
Thio Hu anti-Her2 7C2 LC:K149C
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
CN118436801A PAC 3 |
undisclosed |
Undisclosed |
Mc-Val-Cit-PABC |
[96] |
Thio-Tmab
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
Thio-Tmab-BMPEO-DM1 |
Maytansinoid DM1 |
Microtubule (MT) |
Thio-Tmab-BMPEO-DM1 linker |
[14] |
Thio-Tr (A121C)
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
Thio-Tr (A121C)-BMPEO-DM1 |
Maytansinoid DM1 |
Microtubule (MT) |
Thio-Tr (A121C)-BMPEO-DM1 linker |
[14] |
Tigatuzumab
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
Tigatuzumab-ADC-Tb3-1 |
Tigatuzumab-ADC-Tb3-1 payload |
Undisclosed |
Tigatuzumab-ADC-Tb3-1 linker |
[7] | |
Tigatuzumab-ADC-Tb3-2 |
Tigatuzumab-ADC-Tb3-2 payload |
Undisclosed |
Tigatuzumab-ADC-Tb3-2 linker |
[7] | |
Tigatuzumab-ADC-Tb3-3 |
Tigatuzumab-ADC-Tb3-3 payload |
Undisclosed |
Tigatuzumab-ADC-Tb3-3 linker |
[7] | |
Tigatuzumab-ADC-Tb3-4 |
Tigatuzumab-ADC-Tb3-4 payload |
Undisclosed |
Tigatuzumab-ADC-Tb3-4 linker |
[7] | |
Tigatuzumab-ADC-Tb3-5 |
Tigatuzumab-ADC-Tb3-5 payload |
Undisclosed |
Tigatuzumab-ADC-Tb3-5 linker |
[7] | |
Tigatuzumab-ADC-Tb3-6 |
Tigatuzumab-ADC-Tb3-6 payload |
Undisclosed |
Tigatuzumab-ADC-Tb3-6 linker |
[7] | |
Tigatuzumab-ADC-Tb3-7 |
Tigatuzumab-ADC-Tb3-7 payload |
Undisclosed |
Tigatuzumab-ADC-Tb3-7 linker |
[7] | |
Tigatuzumab-ADC-Tb3-8 |
Tigatuzumab-ADC-Tb3-8 payload |
Undisclosed |
Tigatuzumab-ADC-Tb3-8 linker |
[7] | |
Tigatuzumab-ADC-Tb3-9 |
Tigatuzumab-ADC-Tb3-9 payload |
Undisclosed |
Tigatuzumab-ADC-Tb3-9 linker |
[7] | |
Tigatuzumab-ADC-Tb3-10 |
Tigatuzumab-ADC-Tb3-10 payload |
Undisclosed |
Tigatuzumab-ADC-Tb3-10 linker |
[7] |
TPP-1015
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
WO2024105206A1 30e-1015 1 |
Undisclosed |
Undisclosed |
Undisclosed |
[99] | |
WO2024105206A1 32e-1015 1 |
Undisclosed |
Undisclosed |
Undisclosed |
[99] | |
WO2024105206A1 30e-1015 2 |
22i-5657 Payload |
Undisclosed |
22i-5657 Linker |
[99] | |
WO2024105206A1 32e-1015 2 |
Mdo-cpt |
DNA topoisomerase I (TOP1) |
32p-Avelu Linker |
[99] |
Tra-CAST
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
Tra-CAST-MMAE |
Monomethyl auristatin E |
Microtubule (MT) |
Styrylboronic acid-Val-Cit-PAB |
[100] |
Tras-N3
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
Tras-VC-MMAE |
Monomethyl auristatin E |
Microtubule (MT) |
Mc-Val-Cit-PABC |
[101] |
trast-v1b
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
Trast-v1b- (PF07)2 |
Undisclosed |
Undisclosed |
Undisclosed |
[41] | |
Trast-v1b- (PF15)2 |
Undisclosed |
Undisclosed |
Undisclosed |
[41] |
trast-v2
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
Trast-v2- (PF15)2 |
Undisclosed |
Undisclosed |
Undisclosed |
[41] |
trast-v3
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
Trast-v3- (PF15)2 |
Undisclosed |
Undisclosed |
Undisclosed |
[41] | |
Trast-v3- (PF07)2 |
Undisclosed |
Undisclosed |
Undisclosed |
[41] | |
Trast-v3-PF27 |
Undisclosed |
Undisclosed |
Undisclosed |
[41] | |
Trast-v3-PF22 |
Undisclosed |
Undisclosed |
Undisclosed |
[41] | |
Trast-v3- (201)2 |
Undisclosed |
Undisclosed |
Undisclosed |
[41] |
trast-v5a
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
Trast-v5b- (PF16)2 |
Undisclosed |
Undisclosed |
Undisclosed |
[41] | |
Trast-v5b-PF28 |
Undisclosed |
Undisclosed |
Undisclosed |
[41] |
trast-v5b- (XL05)2
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
Trast-v5b- (XL05-PF09)2 |
Undisclosed |
Undisclosed |
Undisclosed |
[41] |
trast-v5b-XL01
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
Trast-v5b-XL01-PF19 |
Undisclosed |
Undisclosed |
Undisclosed |
[41] | |
Trast-v5b-XL01-PF02 |
Undisclosed |
Undisclosed |
Undisclosed |
[41] | |
Trast-v5b-XL01-PF09 |
Undisclosed |
Undisclosed |
Undisclosed |
[41] |
trast-v5b-XL02
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
Trast-v5b-XL02-PF15 |
Undisclosed |
Undisclosed |
Undisclosed |
[41] |
trast-v5b-XL05
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
Trast-v5b- (XL05)2 1 |
Undisclosed |
Undisclosed |
Undisclosed |
[41] | |
Trast-v5b- (XL05-PF02)2 |
Undisclosed |
Undisclosed |
Undisclosed |
[41] |
trast-v6
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
Trast-v6- (XL05-PF19)2 |
Undisclosed |
Undisclosed |
Undisclosed |
[41] | |
Trast-v6- (PF16)2 |
Undisclosed |
Undisclosed |
Undisclosed |
[41] | |
Trast-v6-PF28 |
Undisclosed |
Undisclosed |
Undisclosed |
[41] |
Trast-v6- (XL05)2
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
Trast-v6- (XL05-PF02)2 |
Undisclosed |
Undisclosed |
Undisclosed |
[41] | |
Trast-v6- (XL05-PF09)2 |
Undisclosed |
Undisclosed |
Undisclosed |
[41] |
trast-v6-XL01
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
Trast-v6-XL01-PF19 1 |
Undisclosed |
Undisclosed |
Undisclosed |
[41] | |
Trast-v6-XL01-PF02 |
Undisclosed |
Undisclosed |
Undisclosed |
[41] | |
Trast-v6-XL01-PF09 |
Undisclosed |
Undisclosed |
Undisclosed |
[41] |
trast-v6-XL02
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
Trast-v6-XL02-PF15 |
Undisclosed |
Undisclosed |
Undisclosed |
[41] |
trast-v6-XL03
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
Trast-v6-XL03-PF15 |
Undisclosed |
Undisclosed |
Undisclosed |
[41] |
trast-v6-XL12
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
Trast-v6-XL12-PF02 |
Undisclosed |
Undisclosed |
Undisclosed |
[41] |
Trast-v7-XL01
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
Trast-v6-XL01-PF19 2 |
Undisclosed |
Undisclosed |
Undisclosed |
[41] |
trast-v7-XL01
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
Trast-v7-XL01-PF02 |
Undisclosed |
Undisclosed |
Undisclosed |
[41] | |
Trast-v7-XL01-PF09 |
Undisclosed |
Undisclosed |
Undisclosed |
[41] |
trast-v8-XL06
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
Trast-v8-XL06-PF02 |
Undisclosed |
Undisclosed |
Undisclosed |
[41] | |
Trast-v8-XL06-PF09 |
Undisclosed |
Undisclosed |
Undisclosed |
[41] |
trast-v9
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
Trast-v9- (PF19)2, |
Undisclosed |
Undisclosed |
Undisclosed |
[41] |
Trastuzumab
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
TAA-013 |
Mertansine DM1 |
Microtubule (MT) |
Succinimidyl-4- (N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC) |
||
B-003 |
Mertansine DM1 |
Microtubule (MT) |
Succinimidyl-4- (N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC) |
||
SHR-A1201 |
Mertansine DM1 |
Microtubule (MT) |
Succinimidyl-4- (N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC) |
||
BI-CON-02 |
Undisclosed |
Undisclosed |
Undisclosed |
||
T-PBA |
PBD-based payload 37b3 |
Human Deoxyribonucleic acid (hDNA) |
Mc-Val-Ala |
[102] | |
Trastuzumab-SYNtansine |
Ahx-maytansine |
Microtubule (MT) |
BCN-HydraSpace-Val-Cit-PABC |
[103] | |
Trastuzumab-Gelonin |
Gelonin |
Ribosome (RB) |
N-succinimidyl 4-(2-pyridyldithio) butanoate (SPDB) |
[104] | |
Anti-HER2_vc-1 |
TLR7 agonist-1 |
Toll-like receptor 7 (TLR7) |
Mc-Val-Cit-PABC |
[105] | |
Tmab-SPP-DM1 |
Mertansine DM1 |
Microtubule (MT) |
N-succinimidyl 4-(2-pyridyldithio) pentanoate (SPP) |
[106] | |
Tmab-SSNPP-DM3 |
Maytansinoid DM3 |
Microtubule (MT) |
Sulfosuccinimidyl-N-succinimidyl-4-(5-nitro-2-pyridyldithio) pentanoate (SSNPP) |
[106] | |
Tmab-SSNPP-DM4 |
Mertansine DM4 |
Microtubule (MT) |
Sulfosuccinimidyl-N-succinimidyl-4-(5-nitro-2-pyridyldithio) pentanoate (SSNPP) |
[106] | |
Trastuzumab-AJICAP-maytansinoid |
Mertansine DM1 |
Microtubule (MT) |
AJICAP |
[107] | |
Trastuzumab-C239I-SG3249 |
SG3199 |
Human Deoxyribonucleic acid (hDNA) |
Mal-PEG8-Val-Ala-PABC |
[108] | |
Tras-Gly5-EDA-Pnu |
PNU-159682 |
DNA topoisomerase 2-alpha (TOP2A) |
Gly5-EDA |
[109] | |
Trastuzumab DVD-ADC |
Monomethyl auristatin F |
Microtubule (MT) |
Hexapeptide linker ASTKGP |
[110] | |
Trastuzumab-Man-beta-1,4GlcNAc-MMAE |
Monomethyl auristatin E |
Microtubule (MT) |
Man-beta-1,4-GlcNAc |
[111] | |
Trastuzumab-Glc-beta-1,4GlcNAc-MMAE |
Monomethyl auristatin E |
Microtubule (MT) |
Glc-beta-1,4GlcNAc |
[111] | |
Trastuzumab-Gal-beta-1,4GlcNAc-MMAE |
Monomethyl auristatin E |
Microtubule (MT) |
Gal-beta-1,4-GlcNAc |
[111] | |
Trastuzumab-MMAE conjugate DAR2 |
Monomethyl auristatin E |
Microtubule (MT) |
Man-beta-1,4-GlcNAc-DBCO-PEG5-VC-PAB |
[112] | |
Trastuzumab-MMAE conjugate DAR4 |
Monomethyl auristatin E |
Microtubule (MT) |
Man-beta-1,4-GlcNAc-DBCO-PEG5-VC-PAB |
[112] | |
Trastuzumab-MMAE conjugate DAR6 |
Monomethyl auristatin E |
Microtubule (MT) |
Man-beta-1,4-GlcNAc-DBCO-PEG5-VC-PAB |
[112] | |
Trastuzumab-MMAE conjugate DAR8 |
Monomethyl auristatin E |
Microtubule (MT) |
Man-beta-1,4-GlcNAc-DBCO-PEG5-VC-PAB |
[112] | |
Trastuzumab-MMAE conjugate DAR12 |
Monomethyl auristatin E |
Microtubule (MT) |
Man-beta-1,4-GlcNAc-DBCO-PEG5-VC-PAB |
[112] | |
Trastuzumab-RSL3-NH2 |
RSL3-NH2 |
Phospholipid hydroperoxide glutathione peroxidase (GPX4) |
Mal-PEG4-DBCO-Ala-Val |
[113] | |
Tras-Gly5-EDA-Dox |
Doxorubicin |
DNA topoisomerase 2-alpha (TOP2A) |
Gly5-EDA |
[109] | |
Tras-Gly5-EDA-Nemo |
Nemorubicin |
DNA topoisomerase 2-alpha (TOP2A) |
Gly5-EDA |
[109] | |
Tras-Gly3-Vakl-Cit-PAB-PNU-159682 |
PNU-159682 |
DNA topoisomerase 2-alpha (TOP2A) |
Gly3-vcPAB |
[109] | |
Tras-Gly5-May |
Mertansine DM1 |
Microtubule (MT) |
Gly5 |
[109] | |
Trastuzumab-SG3227 |
SG2219 |
Human Deoxyribonucleic acid (hDNA) |
Acetamide-PEG4-Val-Ala-PABA |
[48] | |
HER-SG3249 |
SG3199 |
Human Deoxyribonucleic acid (hDNA) |
Mal-PEG8-Val-Ala-PABC |
[114] | |
Site-specific HER-SG3249 |
SG3199 |
Human Deoxyribonucleic acid (hDNA) |
Mal-PEG8-Val-Ala-PABC |
[114] | |
Trastuzumab-SG3600 high DAR |
N10-beta-glucuronide SG3200 |
Human Deoxyribonucleic acid (hDNA) |
Mal-PEG8-Val-Ala-PABC |
[47] | |
LIN-002 |
Undisclosed |
Undisclosed |
Undisclosed |
[115] | |
Trastuzumab-BCN-HydraSpace-Val-Cit-PABC-Gly-Calicheamicin |
Gly-calicheamicin |
Human Deoxyribonucleic acid (hDNA) |
BCN-HydraSpace-Val-Cit-PABC |
[103] | |
HER2 targeted DEP conjugate |
Active metabolite of irinotecan SN38 |
DNA topoisomerase 1 (TOP1) |
Undisclosed |
[116] | |
Trastuzumab SG-3259 |
SG3312 |
Human Deoxyribonucleic acid (hDNA) |
Mc-Val-Ala |
[117] | |
Trastuzumab-SG3400 high DAR |
SG3200 |
Human Deoxyribonucleic acid (hDNA) |
Mal-PEG8-Val-Ala-PABC |
[47] | |
Tra-IR700 |
IRDye 700DX |
Undisclosed |
Undisclosed |
[118] | |
Anti-HER2_vc-7 |
TLR7 agonist-7 |
Toll-like receptor 7 (TLR7) |
Mc-Val-Cit-PABC |
[105] | |
Anti-HER2_vc-2 |
TLR7 agonist-2 |
Toll-like receptor 7 (TLR7) |
Mc-Val-Cit-PABC |
[105] | |
Anti-HER2 antibody-drug conjugate (Spirea) |
Monomethyl auristatin E |
Microtubule (MT) |
Undisclosed |
[119] | |
TTZ-Mc-NPV-MMAE |
Monomethyl auristatin E |
Microtubule (MT) |
Mc-Asn-Pro-Val-PABC |
[120] | |
Adcitmer |
Monomethyl auristatin E |
Microtubule (MT) |
Pyridino-caproic-Val-Cit-PABC |
[121] | |
Trastuzumab-BCN-HydraSpace-Val-Cit-PABC-MMAE |
Monomethyl auristatin E |
Microtubule (MT) |
BCN-HydraSpace-Val-Cit-PABC |
[103] | |
MF-TTZ-MMAE |
Monomethyl auristatin E |
Microtubule (MT) |
Dibromomethyl pyridine-Val-Cit-PABC |
[122] | |
FGM-TTZ-MMAE |
Monomethyl auristatin E |
Microtubule (MT) |
Mc-Val-Cit-PABC |
[122] | |
NC-ADC |
Monomethyl auristatin E |
Microtubule (MT) |
Divinylpyrimidine-PEG4 |
[123] | |
C-ADC |
Monomethyl auristatin E |
Microtubule (MT) |
Divinylpyrimidine-PEG4-Val-Ala-PABC |
[123] | |
Tmab-SPDP-DM1 |
Mertansine DM1 |
Microtubule (MT) |
N-succinimidyl 4-(2-pyridyldithio) butanoate (SPDB) |
[106] | |
T-K-F (DAR 3.9) |
Monomethyl auristatin F |
Microtubule (MT) |
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC) |
[124] | |
T-C-F (DAR 3.7) |
Monomethyl auristatin F |
Microtubule (MT) |
Maleimido-caproyl |
[124] | |
Trastuzumab-PNU-159682 Antibody-Drug Conjugate |
PNU-159682 |
DNA topoisomerase 2-alpha (TOP2A) |
Undisclosed |
[125] | |
Trastuzumab-BCN-HydraSpace-Val-Cit-PABC-PNU-159682 |
PNU-159682 |
DNA topoisomerase 2-alpha (TOP2A) |
BCN-HydraSpace-Val-Cit-PABC |
[126] | |
Trastuzumab-G5-PNU |
PNU-159682 |
DNA topoisomerase 2-alpha (TOP2A) |
Gly5-FITC |
[109] | |
PRO-1102 |
Exatecan |
DNA topoisomerase 1 (TOP1) |
Cleavable hydrophilic linker |
[127] | |
Tra-Exa-PSAR10 |
Exatecan |
DNA topoisomerase 1 (TOP1) |
Mal-Exa-PSAR10 |
[128] | |
Tra-Exa-PSAR0 |
Exatecan |
DNA topoisomerase 1 (TOP1) |
Mal-Exa-PSAR0 |
[128] | |
T-N-F (DAR 3.2) |
Aldehyde-tagged MMAF |
Microtubule (MT) |
Undisclosed |
[124] | |
T-N-F (DAR 1.6) |
Aldehyde-tagged MMAF |
Microtubule (MT) |
Undisclosed |
[124] | |
Tras-ALN |
Alendronate |
Farnesyl pyrophosphate synthase (FDPS) |
Bicyclo[6.1.0]nona-4-yne |
[129] | |
Trastuzumab-ATAC |
Alpha-amanitin |
DNA-directed RNA polymerase II subunit RPB2 (POLR2B); DNA-directed RNA polymerase III subunit RPC7 (POLR3G) |
Undisclosed |
[130] | |
CRD-5500 antibody-drug conjugate |
CRD5500 |
Stimulator of interferon genes protein (STING1) |
Undisclosed |
[131] | |
Trastuzumab-deBouganin |
DeBouganin |
Microtubule (MT) |
Undisclosed |
[132] | |
Trastuzumab-BCN-HydraSpace-Val-Cit-PABC-Duocarmycin |
Duocarmycin Sa |
Human Deoxyribonucleic acid (hDNA) |
BCN-HydraSpace-Val-Cit-PABC |
[103] | |
Trastuzumab-BCN-HydraSpace-Val-Cit-PABC-Calicheamicin |
N-acetyl-gamma-calicheamicin |
Human Deoxyribonucleic acid (hDNA) |
BCN-HydraSpace-Val-Cit-PABC |
[103] | |
MYX2449 |
N-Myristolytransferase inhibitor (NMTi) |
Glycylpeptide N-tetradecanoyltransferase 1 (NMT1) |
Undisclosed |
[133] | |
Trastuzumab-BCN-HydraSpace-Val-Ala-PABC-PBD dimer |
PBD dimer 2 |
Human Deoxyribonucleic acid (hDNA) |
BCN-HydraSpace-Val-Ala-PABC |
[103] | |
MI-130004 |
PM050489 |
Microtubule (MT) |
6-(2,5-dioxopyrrol-1-yl)-N-Propylhexanamide |
[134] | |
Trastuzumab-DNA mimic 4 |
Q Pho-DNA mimics |
Human Deoxyribonucleic acid (hDNA) |
Diphenyltio-Mal-Cap |
[135] | |
ST8176AA1 |
ST7612AA1 |
Histone deacetylase 1 (HDAC1) |
Maleimide-thiol linker |
[136] | |
Trastuzumab-L3-TL |
Triptolide |
Nuclear factor NF-kappa-B p105 subunit (NFKB1) |
BVP-PEG3-carbamate-PEG4 |
[137] | |
Trastuzumab-L2-TL |
Triptolide |
Nuclear factor NF-kappa-B p105 subunit (NFKB1) |
BVP-PEG3-diamine |
[137] | |
Trastuzumab-L1-TL |
Triptolide |
Nuclear factor NF-kappa-B p105 subunit (NFKB1) |
BVP-PEG3-carbamate |
[137] | |
Trastuzumab-L6 |
MF-6 |
DNA topoisomerase 1 (TOP1) |
Bridged PEG4-valine-alanine |
[138] | |
ADC Trast-7 |
Monomethyl auristatin E |
Microtubule (MT) |
Undisclosed |
[139] | |
ADC Trast-10 |
Monomethyl auristatin E |
Microtubule (MT) |
Bis-BCN-modified Val-Cit-PABC linker 10 |
[139] | |
ADC Trast-14 |
PBD dimer 3 |
Human Deoxyribonucleic acid (hDNA) |
Undisclosed |
[139] | |
ADC Trast-11 |
PBD dimer 3 |
Human Deoxyribonucleic acid (hDNA) |
Bis-BCN-modified Val-Cit-PABC linker 10 |
[139] | |
Trastuzumab-MCC-CpG conjugate |
Differentiated TLR-9 agonist (T-CpG) |
Toll-like receptor 9 (TLR9) |
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC) |
[140] | |
Trastuzumab-T1000-exatecan |
Exatecan |
DNA topoisomerase 1 (TOP1) |
Undisclosed |
[141] | |
Trastuzumab-NGM-PROTAC conjugate |
BRD4 PROTAC 3 |
Bromodomain-containing protein 4 (BRD4) |
NGM based linker |
[142] | |
Trastuzumab-iCME |
Membrane-impermable colchinolmethyl ether (iCME) cytotoxin |
Microtubule (MT) |
Pacific blue fluorophore-SH based linker |
[143] | |
IgG1 (trastuzumab)-vc-MMAE |
Monomethyl auristatin E |
Microtubule (MT) |
Mc-Val-Cit-PABC |
[19] | |
Trastuzumab-DNA conjugate |
DNA mimics |
Human Deoxyribonucleic acid (hDNA) |
Undisclosed |
[144] | |
OHPAS ADC-1 |
Alpha-amanitin |
DNA-directed RNA polymerase II subunit RPB2 (POLR2B); DNA-directed RNA polymerase III subunit RPC7 (POLR3G) |
Ortho-hydroxy-protected aryl sulfate |
[145] | |
OHPAS ADC-2 |
SG2000 |
Human Deoxyribonucleic acid (hDNA) |
Ortho-hydroxy-protected aryl sulfate |
[145] | |
OHPAS ADC-3 |
seco-CBI-indole |
Human Deoxyribonucleic acid (hDNA) |
Ortho-hydroxy-protected aryl sulfate |
[145] | |
OHPAS ADC-4 |
CBI-dimer-beta-Gal |
Human Deoxyribonucleic acid (hDNA) |
Ortho-hydroxy-protected aryl sulfate |
[145] | |
Trastuzumab/nab-paclitaxel |
Paclitaxel |
Microtubule (MT) |
Undisclosed |
[146] | |
Docetaxel-trastuzumab |
Docetaxel |
Microtubule (MT) |
Undisclosed |
[147] | |
Trastuzumab-PC4AP-DOX |
Doxorubicin |
DNA topoisomerase 2-alpha (TOP2A) |
Photocaged C4AP |
[148] | |
Trastuzumab-PNUEDAGly5 |
PNU-159682 |
DNA topoisomerase 2-alpha (TOP2A) |
LPETG-Gly5-EDA |
[149] | |
T (Anti-HER2)-30.2060 |
Amanitin 30.206 |
DNA-directed RNA polymerase II subunit RPB2 (POLR2B); DNA-directed RNA polymerase III subunit RPC7 (POLR3G) |
Mc-Val-Ala-PABC |
[31] | |
T (Anti-HER2)-30.2867 |
Amanitin 30.2867 |
DNA-directed RNA polymerase II subunit RPB2 (POLR2B); DNA-directed RNA polymerase III subunit RPC7 (POLR3G) |
Maleimido-caproyl |
[31] | |
ADC2-2 |
ADC 2-2 payload |
DNA topoisomerase 1 (TOP1) |
ADC 2-2 linker |
[150] | |
ADC2-4 |
ADC 2-4 payload |
DNA topoisomerase 1 (TOP1) |
ADC 2-4 linker |
[150] | |
ADC2-6-2 |
ADC 2-6-2 payload |
DNA topoisomerase 1 (TOP1) |
ADC 2-6-2 linker |
[150] | |
ADC2-7-2 |
ADC 2-7-2 payload |
DNA topoisomerase 1 (TOP1) |
ADC 2-7-2 linker |
[150] | |
ADC2-9-1 |
ADC 2-9-1 payload |
DNA topoisomerase 1 (TOP1) |
ADC 2-9-1 linker |
[150] | |
ADC2-9-2 |
ADC 2-9-2 payload |
DNA topoisomerase 1 (TOP1) |
ADC 2-9-2 linker |
[150] | |
ADC2-10 |
ADC 2-10 payload |
DNA topoisomerase 1 (TOP1) |
ADC 2-10 linker |
[150] | |
ADC2-11 |
ADC 2-11 payload |
DNA topoisomerase 1 (TOP1) |
ADC 2-11 linker |
[150] | |
ADC2-22 |
ADC 2-22 payload |
DNA topoisomerase 1 (TOP1) |
ADC 2-22 linker |
[150] | |
ADC2-23 |
ADC 2-23 payload |
DNA topoisomerase 1 (TOP1) |
ADC 2-23 linker |
[150] | |
ADC2-24 |
ADC 2-24 payload |
DNA topoisomerase 1 (TOP1) |
ADC 2-24 linker |
[150] | |
ADC2-25 |
ADC 2-25 payload |
DNA topoisomerase 1 (TOP1) |
ADC 2-25 linker |
[150] | |
ADC2-26 |
ADC 2-26 payload |
DNA topoisomerase 1 (TOP1) |
ADC 2-26 linker |
[150] | |
ADC2-27 |
ADC 2-27 payload |
DNA topoisomerase 1 (TOP1) |
ADC 2-27 linker |
[150] | |
ADC2-29 |
ADC 2-29 payload |
DNA topoisomerase 1 (TOP1) |
ADC 2-29 linker |
[150] | |
ADC2-30 |
ADC 2-30 payload |
DNA topoisomerase 1 (TOP1) |
ADC 2-30 linker |
[150] | |
ADC2-31 |
ADC 2-31 payload |
DNA topoisomerase 1 (TOP1) |
ADC 2-31 linker |
[150] | |
ADC2-32 |
ADC 2-32 payload |
DNA topoisomerase 1 (TOP1) |
ADC 2-32 linker |
[150] | |
ADC2-33 |
ADC 2-33 payload |
DNA topoisomerase 1 (TOP1) |
ADC 2-33 linker |
[150] | |
ADC2-34 |
ADC 2-34 payload |
DNA topoisomerase 1 (TOP1) |
ADC 2-34 linker |
[150] | |
ADC2-35 |
ADC 2-35 payload |
DNA topoisomerase 1 (TOP1) |
ADC 2-35 linker |
[150] | |
ADC2-36-1 |
ADC 2-36-1 payload |
DNA topoisomerase 1 (TOP1) |
ADC 2-36-1 linker |
[150] | |
ADC2-36-2 |
ADC 2-36-2 payload |
DNA topoisomerase 1 (TOP1) |
ADC 2-36-2 linker |
[150] | |
ADC2-37 |
ADC 2-37 payload |
DNA topoisomerase 1 (TOP1) |
ADC 2-37 linker |
[150] | |
ADC2-38 |
ADC 2-38 payload |
DNA topoisomerase 1 (TOP1) |
ADC 2-38 linker |
[150] | |
ADC2-39 |
ADC 2-39 payload |
DNA topoisomerase 1 (TOP1) |
ADC 2-39 linker |
[150] | |
ADC2-40 |
ADC 2-40 payload |
DNA topoisomerase 1 (TOP1) |
ADC 2-40 linker |
[150] | |
ADC2-41 |
ADC 2-41 payload |
DNA topoisomerase 1 (TOP1) |
ADC 2-41 linker |
[150] | |
ADC2-42 |
ADC 2-42 payload |
DNA topoisomerase 1 (TOP1) |
ADC 2-42 linker |
[150] | |
ADC2-42-RO |
ADC 2-42-RO payload |
DNA topoisomerase 1 (TOP1) |
ADC 2-42-RO linker |
[150] | |
ADC2-43 |
ADC 2-43 payload |
DNA topoisomerase 1 (TOP1) |
ADC 2-43 linker |
[150] | |
ADC2-44 |
ADC 2-44 payload |
DNA topoisomerase 1 (TOP1) |
ADC 2-44 linker |
[150] | |
ADC2-45 |
ADC 2-45 payload |
DNA topoisomerase 1 (TOP1) |
ADC 2-45 linker |
[150] | |
ADC2-46 |
ADC 2-46 payload |
DNA topoisomerase 1 (TOP1) |
ADC 2-46 linker |
[150] | |
ADC2-47 |
ADC 2-47 payload |
DNA topoisomerase 1 (TOP1) |
ADC 2-47 linker |
[150] | |
ADC2-48 |
ADC 2-48 payload |
DNA topoisomerase 1 (TOP1) |
ADC 2-48 linker |
[150] | |
ADC2-49 |
ADC 2-49 payload |
DNA topoisomerase 1 (TOP1) |
ADC 2-49 linker |
[150] | |
ADC2-50 |
ADC 2-50 payload |
DNA topoisomerase 1 (TOP1) |
ADC 2-50 linker |
[150] | |
ADC2-51 |
ADC 2-51 payload |
DNA topoisomerase 1 (TOP1) |
ADC 2-51 linker |
[150] | |
ADC2-53 |
ADC 2-53 payload |
DNA topoisomerase 1 (TOP1) |
ADC 2-53 linker |
[150] | |
ADC2-54 |
ADC 2-54 payload |
DNA topoisomerase 1 (TOP1) |
ADC 2-54 linker |
[150] | |
ADC2-55 |
ADC 2-55 payload |
DNA topoisomerase 1 (TOP1) |
ADC 2-55 linker |
[150] | |
ADC2-56 |
ADC 2-56 payload |
DNA topoisomerase 1 (TOP1) |
ADC 2-56 linker |
[150] | |
ADC2-57 |
ADC 2-57 payload |
DNA topoisomerase 1 (TOP1) |
ADC 2-57 linker |
[150] | |
ADC2-58 |
ADC 2-58 payload |
DNA topoisomerase 1 (TOP1) |
ADC 2-58 linker |
[150] | |
ADC2-59 |
ADC 2-59 payload |
DNA topoisomerase 1 (TOP1) |
ADC 2-59 linker |
[150] | |
ADC2-60 |
ADC 2-60 payload |
DNA topoisomerase 1 (TOP1) |
ADC 2-60 linker |
[150] | |
ADC2-61 |
ADC 2-61 payload |
DNA topoisomerase 1 (TOP1) |
ADC 2-61 linker |
[150] | |
ADC-2-62-1 |
ADC 2-62-1 payload |
DNA topoisomerase 1 (TOP1) |
ADC 2-62-1 linker |
[150] | |
ADC-2-62-2 |
ADC 2-62-2 payload |
DNA topoisomerase 1 (TOP1) |
ADC 2-62-2 linker |
[150] | |
ADC-2-63-1 |
ADC 2-63-1 payload |
DNA topoisomerase 1 (TOP1) |
ADC 2-63-1 linker |
[150] | |
ADC-2-63-2 |
ADC 2-63-2 payload |
DNA topoisomerase 1 (TOP1) |
ADC 2-63-2 linker |
[150] | |
ADC-2-64-1 |
ADC 2-64-1 payload |
DNA topoisomerase 1 (TOP1) |
ADC 2-64-1 linker |
[150] | |
ADC-2-64-2 |
ADC 2-64-2 payload |
DNA topoisomerase 1 (TOP1) |
ADC 2-64-2 linker |
[150] | |
ADC-2-65-1 |
ADC 2-65-1 payload |
DNA topoisomerase 1 (TOP1) |
ADC 2-65-1 linker |
[150] | |
ADC-2-65-2 |
ADC 2-65-2 payload |
DNA topoisomerase 1 (TOP1) |
ADC 2-65-2 linker |
[150] | |
ADC3-1 |
ADC 3-1 payload |
DNA topoisomerase 1 (TOP1) |
ADC 3-1 linker |
[150] | |
ADC3-2 |
ADC 3-2 payload |
DNA topoisomerase 1 (TOP1) |
ADC 3-2 linker |
[150] | |
ADC3-3 |
ADC 3-3 payload |
DNA topoisomerase 1 (TOP1) |
ADC 3-3 linker |
[150] | |
ADC3-4 |
ADC 3-4 payload |
DNA topoisomerase 1 (TOP1) |
ADC 3-4 linker |
[150] | |
ADC3-5 |
ADC 3-5 payload |
DNA topoisomerase 1 (TOP1) |
ADC 3-5 linker |
[150] | |
ADC2-A |
ADC 2-A payload |
DNA topoisomerase 1 (TOP1) |
ADC 2-A linker |
[150] | |
ADC2-B |
ADC 2-B payload |
DNA topoisomerase 1 (TOP1) |
ADC 2-B linker |
[150] | |
ADC2-12 |
ADC 2-12 payload |
DNA topoisomerase 1 (TOP1) |
ADC 2-12 linker |
[150] | |
HER2-ADC-01 (DAR8) |
HER2-ADC-01(DAR8) payload |
Undisclosed |
HER2-ADC-01(DAR8) linker |
[7] | |
HER2-ADC-02 (DAR8) |
HER2-ADC-02(DAR8) payload |
Undisclosed |
HER2-ADC-02(DAR8) linker |
[7] | |
HER2-ADC-03 (DAR8) |
HER2-ADC-03(DAR8) payload |
Undisclosed |
HER2-ADC-03(DAR8) linker |
[7] | |
HER2-ADC-04 (DAR8) |
HER2-ADC-04(DAR8) payload |
Undisclosed |
HER2-ADC-04(DAR8) linker |
[7] | |
HER2-ADC-05 (DAR8) |
HER2-ADC-05(DAR8) payload |
Undisclosed |
HER2-ADC-05(DAR8) linker |
[7] | |
HER2-ADC-06 (DAR8) |
HER2-ADC-06(DAR8) payload |
Undisclosed |
HER2-ADC-06(DAR8) linker |
[7] | |
HER2-ADC-07 (DAR8) |
HER2-ADC-07(DAR8) payload |
Undisclosed |
HER2-ADC-07(DAR8) linker |
[7] | |
HER2-ADC-08 (DAR8) |
HER2-ADC-08(DAR8) payload |
Undisclosed |
HER2-ADC-08(DAR8) linker |
[7] | |
HER2-ADC-09 (DAR8) |
HER2-ADC-09(DAR8) payload |
Undisclosed |
HER2-ADC-09(DAR8) linker |
[7] | |
HER2-ADC-10 (DAR8) |
HER2-ADC-10(DAR8) payload |
Undisclosed |
HER2-ADC-10(DAR8) linker |
[7] | |
WO2020063676A1 ADC-1 |
WO2020063676A1_ADC-1 payload |
Undisclosed |
WO2020063676A1_ADC-1 linker |
[82] | |
WO2020063676A1 ADC-2 |
WO2020063676A1_ADC-2 payload |
Undisclosed |
WO2020063676A1_ADC-2 linker |
[82] | |
WO2020063676A1 ADC-3 |
WO2020063676A1_ADC-3 payload |
Undisclosed |
WO2020063676A1_ADC-3 linker |
[82] | |
WO2020063676A1 ADC-4 |
WO2020063676A1_ADC-4 payload |
Undisclosed |
WO2020063676A1_ADC-4 linker |
[82] | |
WO2020063676A1 ADC-5 |
WO2020063676A1_ADC-5 payload |
Undisclosed |
WO2020063676A1_ADC-5 linker |
[82] | |
WO2020063676A1 ADC-6 |
WO2020063676A1_ADC-6 payload |
Undisclosed |
WO2020063676A1_ADC-6 linker |
[82] | |
WO2020063676A1 ADC-10 |
WO2020063676A1_ADC-10 payload |
Undisclosed |
WO2020063676A1_ADC-10 linker |
[82] | |
WO2020063676A1 ADC-11 |
WO2020063676A1_ADC-11 payload |
Undisclosed |
WO2020063676A1_ADC-11 linker |
[82] | |
WO2020063676A1 ADC-12 |
WO2020063676A1_ADC-12 payload |
Undisclosed |
WO2020063676A1_ADC-12 linker |
[82] | |
WO2020063676A1 ADC-13 |
WO2020063676A1_ADC-13 payload |
Undisclosed |
WO2020063676A1_ADC-13 linker |
[82] | |
WO2020063676A1 ADC-14 |
WO2020063676A1_ADC-14 payload |
Undisclosed |
WO2020063676A1_ADC-14 linker |
[82] | |
WO2020063676A1 ADC-15 |
WO2020063676A1_ADC-15 payload |
Undisclosed |
WO2020063676A1_ADC-15 linker |
[82] | |
WO2020063676A1 ADC-16 |
WO2020063676A1_ADC-16 payload |
Undisclosed |
WO2020063676A1_ADC-16 linker |
[82] | |
WO2020063676A1 ADC-17 |
WO2020063676A1_ADC-17 payload |
Undisclosed |
WO2020063676A1_ADC-17 linker |
[82] | |
WO2020063676A1 ADC-18 |
WO2020063676A1_ADC-18 payload |
Undisclosed |
WO2020063676A1_ADC-18 linker |
[82] | |
WO2020063676A1 ADC-19 |
WO2020063676A1_ADC-19 payload |
Undisclosed |
WO2020063676A1_ADC-19 linker |
[82] | |
WO2020063676A1 ADC-20 |
WO2020063676A1_ADC-20 payload |
Undisclosed |
WO2020063676A1_ADC-20 linker |
[82] | |
WO2020063676A1 ADC-21 |
WO2020063676A1_ADC-21 payload |
Undisclosed |
WO2020063676A1_ADC-21 linker |
[82] | |
WO2020063676A1 ADC-22 |
WO2020063676A1_ADC-22 payload |
Undisclosed |
WO2020063676A1_ADC-22 linker |
[82] | |
WO2020063676A1 ADC-23 |
WO2020063676A1_ADC-23 payload |
Undisclosed |
WO2020063676A1_ADC-23 linker |
[82] | |
WO2020063676A1 ADC-24 |
WO2020063676A1_ADC-24 payload |
Undisclosed |
WO2020063676A1_ADC-24 linker |
[82] | |
Trastuzumab-Compound (la) DAR 1.6 |
NeoDegrader P1 |
Protein cereblon (CRBN) |
Trastuzumab-Compound (la) DAR 1.6 linker |
[83] | |
Trastuzumab-Compound (la) DAR 8 |
NeoDegrader P1 |
Protein cereblon (CRBN) |
Trastuzumab-Compound (la) DAR 8 linker |
[83] | |
Trastuzumab-Compound (Ib) DAR1.5 |
NeoDegrader P3 |
Protein cereblon (CRBN) |
Trastuzumab-Compound (Ib) DAR1.5 linker |
[83] | |
Trastuzumab-Compound (lc) |
NeoDegrader P4 |
Protein cereblon (CRBN) |
Trastuzumab-Compound (lc) linker |
[83] | |
Trastuzumab-Compound (lc) DAR 8 |
NeoDegrader P4 |
Protein cereblon (CRBN) |
Trastuzumab-Compound (lc) DAR 8 linker |
[83] | |
Trastuzumab-Compound (ld) DAR 1.6 |
NeoDegrader P1 |
Protein cereblon (CRBN) |
Trastuzumab-Compound (ld) DAR 1.6 linker |
[83] | |
Trastuzumab-Compound (le) |
NeoDegrader P1 |
Protein cereblon (CRBN) |
Trastuzumab-Compound (le) linker |
[83] | |
Trastuzumab-Compound (lf) |
NeoDegrader P6 |
Protein cereblon (CRBN) |
Trastuzumab-Compound (lf) linker |
[83] | |
Trastuzumab-Compound (lg) |
NeoDegrader P2 |
Protein cereblon (CRBN) |
Trastuzumab-Compound (lg) linker |
[83] | |
Trastuzumab-Compound (lh) |
NeoDegrader P13 |
Protein cereblon (CRBN) |
Trastuzumab-Compound (lh) linker |
[83] | |
Trastuzumab-Compound (li) |
NeoDegrader P1 |
Protein cereblon (CRBN) |
Trastuzumab-Compound (li) linker |
[83] | |
Trastuzumab-Compound (lj) |
NeoDegrader P1 |
Protein cereblon (CRBN) |
Trastuzumab-Compound (lj) linker |
[83] | |
Trastuzumab-Compound (lk) |
NeoDegrader P14 |
Protein cereblon (CRBN) |
Trastuzumab-Compound (lk) linker |
[83] | |
Trastuzumab-Compound (ll) |
NeoDegrader P14 |
Protein cereblon (CRBN) |
Trastuzumab-Compound (ll) linker |
[83] | |
Trastuzumab-Compound (lm) |
NeoDegrader P14 |
Protein cereblon (CRBN) |
Trastuzumab-Compound (lm) linker |
[83] | |
WO2017089895A1 ADC1 |
Monomethyl auristatin E |
Microtubule (MT) |
WO2017089895A1_ADC1 linker |
[151] | |
WO2017089895A1 ADC2 |
Monomethyl auristatin F |
Microtubule (MT) |
WO2017089895A1_ADC2 linker |
[151] | |
WO2017089895A1 ADC3 |
Monomethyl auristatin E |
Microtubule (MT) |
WO2017089895A1_ADC3 linker |
[151] | |
WO2017089895A1 ADC4 |
Monomethyl auristatin F |
Microtubule (MT) |
WO2017089895A1_ADC4 linker |
[151] | |
WO2017089895A1 ADC5 |
Monomethyl auristatin E |
Microtubule (MT) |
WO2017089895A1_ADC5 linker |
[151] | |
WO2017089895A1 ADC6 |
Monomethyl auristatin F |
Microtubule (MT) |
WO2017089895A1_ADC6 linker |
[151] | |
WO2017089895A1 ADC7 |
Monomethyl auristatin E |
Microtubule (MT) |
WO2017089895A1_ADC7 linker |
[151] | |
WO2017089895A1 ADC8 |
Monomethyl auristatin F |
Microtubule (MT) |
WO2017089895A1_ADC8 linker |
[151] | |
WO2017089895A1 ADC9 |
Monomethyl auristatin E |
Microtubule (MT) |
WO2017089895A1_ADC9 linker |
[151] | |
WO2017089895A1 ADC10 |
Monomethyl auristatin E |
Microtubule (MT) |
WO2017089895A1_ADC10 linker |
[151] | |
WO2017089895A1 ADC11 |
Monomethyl auristatin E |
Microtubule (MT) |
WO2017089895A1_ADC11 linker |
[151] | |
WO2017089895A1 ADC12 |
Monomethyl auristatin E |
Microtubule (MT) |
WO2017089895A1_ADC12 linker |
[151] | |
WO2017089895A1 ADC13 |
Monomethyl auristatin E |
Microtubule (MT) |
WO2017089895A1_ADC13 linker |
[151] | |
WO2017089895A1 ADC14 |
Monomethyl auristatin F |
Microtubule (MT) |
WO2017089895A1_ADC14 linker |
[151] | |
WO2017089895A1 ADC15 |
Monomethyl auristatin E |
Microtubule (MT) |
WO2017089895A1_ADC15 linker |
[151] | |
WO2017089895A1 ADC16 |
Monomethyl auristatin F |
Microtubule (MT) |
WO2017089895A1_ADC16 linker |
[151] | |
WO2017089895A1 ADC17 |
Monomethyl auristatin E |
Microtubule (MT) |
WO2017089895A1_ADC17 linker |
[151] | |
WO2017089895A1 ADC18 |
Monomethyl auristatin F |
Microtubule (MT) |
WO2017089895A1_ADC18 linker |
[151] | |
WO2017089895A1 ADC19 |
Monomethyl auristatin E |
Microtubule (MT) |
WO2017089895A1_ADC19 linker |
[151] | |
WO2017089895A1 ADC20 |
Monomethyl auristatin F |
Microtubule (MT) |
WO2017089895A1_ADC20 linker |
[151] | |
WO2017089895A1 ADC86 |
Monomethyl auristatin F |
Microtubule (MT) |
WO2017089895A1_ADC86 linker |
[151] | |
WO2017089895A1 ADC87 |
Monomethyl auristatin E |
Microtubule (MT) |
WO2017089895A1_ADC87 linker |
[151] | |
WO2017089895A1 ADC23 |
Monomethyl auristatin F |
Microtubule (MT) |
WO2017089895A1_ADC23 linker |
[151] | |
WO2017089895A1 ADC24 |
Monomethyl auristatin E |
Microtubule (MT) |
WO2017089895A1_ADC24 linker |
[151] | |
WO2017089895A1 ADC25 |
Monomethyl auristatin E |
Microtubule (MT) |
WO2017089895A1_ADC25 linker |
[151] | |
WO2017089895A1 ADC26 |
Monomethyl auristatin E |
Microtubule (MT) |
WO2017089895A1_ADC26 linker |
[151] | |
WO2017089895A1 ADC27 |
Monomethyl auristatin E |
Microtubule (MT) |
WO2017089895A1_ADC27 linker |
[151] | |
WO2017089895A1 ADC28 |
Monomethyl auristatin E |
Microtubule (MT) |
WO2017089895A1_ADC28 linker |
[151] | |
WO2017089895A1 ADC29 |
Monomethyl auristatin E |
Microtubule (MT) |
WO2017089895A1_ADC29 linker |
[151] | |
WO2017089895A1 ADC30 |
Monomethyl auristatin E |
Microtubule (MT) |
WO2017089895A1_ADC30 linker |
[151] | |
WO2017089895A1 ADC31 |
Monomethyl auristatin E |
Microtubule (MT) |
WO2017089895A1_ADC31 linker |
[151] | |
WO2017089895A1 ADC32 |
Monomethyl auristatin E |
Microtubule (MT) |
WO2017089895A1_ADC32 linker |
[151] | |
WO2017089895A1 ADC33 |
Monomethyl auristatin E |
Microtubule (MT) |
WO2017089895A1_ADC33 linker |
[151] | |
WO2017089895A1 ADC34 |
Monomethyl auristatin F |
Microtubule (MT) |
WO2017089895A1_ADC34 linker |
[151] | |
WO2017089895A1 ADC35 |
Monomethyl auristatin E |
Microtubule (MT) |
WO2017089895A1_ADC35 linker |
[151] | |
WO2017089895A1 ADC36 |
Monomethyl auristatin E |
Microtubule (MT) |
WO2017089895A1_ADC36 linker |
[151] | |
WO2017089895A1 ADC37 |
Monomethyl auristatin E |
Microtubule (MT) |
WO2017089895A1_ADC37 linker |
[151] | |
WO2017089895A1 ADC38 |
Monomethyl auristatin F |
Microtubule (MT) |
WO2017089895A1_ADC38 linker |
[151] | |
WO2017089895A1 ADC39 |
Monomethyl auristatin E |
Microtubule (MT) |
WO2017089895A1_ADC39 linker |
[151] | |
WO2017089895A1 ADC40 |
Monomethyl auristatin F |
Microtubule (MT) |
WO2017089895A1_ADC40 linker |
[151] | |
WO2017089895A1 ADC41 |
Monomethyl auristatin E |
Microtubule (MT) |
WO2017089895A1_ADC41 linker |
[151] | |
WO2017089895A1 ADC42 |
Monomethyl auristatin F |
Microtubule (MT) |
WO2017089895A1_ADC42 linker |
[151] | |
WO2017089895A1 ADC43 |
Monomethyl auristatin E |
Microtubule (MT) |
WO2017089895A1_ADC43 linker |
[151] | |
WO2017089895A1 ADC44 |
Monomethyl auristatin F |
Microtubule (MT) |
WO2017089895A1_ADC44 linker |
[151] | |
WO2017089895A1 ADC45 |
Monomethyl auristatin E |
Microtubule (MT) |
WO2017089895A1_ADC45 linker |
[151] | |
WO2017089895A1 ADC46 |
Monomethyl auristatin F |
Microtubule (MT) |
WO2017089895A1_ADC46 linker |
[151] | |
WO2017089895A1 ADC47 |
Monomethyl auristatin E |
Microtubule (MT) |
WO2017089895A1_ADC47 linker |
[151] | |
WO2017089895A1 ADC48 |
Monomethyl auristatin F |
Microtubule (MT) |
WO2017089895A1_ADC48 linker |
[151] | |
WO2017089895A1 ADC49 |
Monomethyl auristatin E |
Microtubule (MT) |
WO2017089895A1_ADC49 linker |
[151] | |
WO2017089895A1 ADC50 |
Monomethyl auristatin F |
Microtubule (MT) |
WO2017089895A1_ADC50 linker |
[151] | |
WO2017089895A1 ADC51 |
Monomethyl auristatin E |
Microtubule (MT) |
WO2017089895A1_ADC51 linker |
[151] | |
WO2017089895A1 ADC52 |
Monomethyl auristatin E |
Microtubule (MT) |
WO2017089895A1_ADC52 linker |
[151] | |
WO2017089895A1 ADC53 |
Monomethyl auristatin F |
Microtubule (MT) |
WO2017089895A1_ADC53 linker |
[151] | |
WO2017089895A1 ADC54 |
Monomethyl auristatin F |
Microtubule (MT) |
WO2017089895A1_ADC54 linker |
[151] | |
WO2017089895A1 ADC55 |
Monomethyl auristatin F |
Microtubule (MT) |
WO2017089895A1_ADC55 linker |
[151] | |
WO2017089895A1 ADC76 |
Monomethyl auristatin F |
Microtubule (MT) |
WO2017089895A1_ADC76 linker |
[151] | |
WO2017089895A1 ADC88 |
Monomethyl auristatin F |
Microtubule (MT) |
WO2017089895A1_ADC88 linker |
[151] | |
WO2017089895A1 ADC89 |
Monomethyl auristatin F |
Microtubule (MT) |
WO2017089895A1_ADC89 linker |
[151] | |
WO2017089895A1 ADC90 |
Monomethyl auristatin F |
Microtubule (MT) |
WO2017089895A1_ADC90 linker |
[151] | |
WO2017089895A1 ADC91 |
Monomethyl auristatin E |
Microtubule (MT) |
WO2017089895A1_ADC91 linker |
[151] | |
WO2017089895A1 ADC60 |
Monomethyl auristatin F |
Microtubule (MT) |
WO2017089895A1_ADC60 linker |
[151] | |
WO2017089895A1 ADC61 |
Monomethyl auristatin E |
Microtubule (MT) |
WO2017089895A1_ADC61 linker |
[151] | |
WO2017089895A1 ADC62 |
Monomethyl auristatin F |
Microtubule (MT) |
WO2017089895A1_ADC62 linker |
[151] | |
WO2017089895A1 ADC63 |
Monomethyl auristatin E |
Microtubule (MT) |
WO2017089895A1_ADC63 linker |
[151] | |
WO2017089895A1 ADC77 |
Monomethyl auristatin F |
Microtubule (MT) |
WO2017089895A1_ADC77 linker |
[151] | |
WO2017089895A1 ADC21 |
Alpha-amanitin |
DNA-directed RNA polymerase II subunit RPB2 (POLR2B); DNA-directed RNA polymerase III subunit RPC7 (POLR3G) |
WO2017089895A1_ADC21 linker |
[151] | |
WO2017089895A1 ADC22 |
Alpha-amanitin |
DNA-directed RNA polymerase II subunit RPB2 (POLR2B); DNA-directed RNA polymerase III subunit RPC7 (POLR3G) |
WO2017089895A1_ADC22 linker |
[151] | |
WO2017089895A1 ADC56 |
Alpha-amanitin |
DNA-directed RNA polymerase II subunit RPB2 (POLR2B); DNA-directed RNA polymerase III subunit RPC7 (POLR3G) |
WO2017089895A1_ADC56 linker |
[151] | |
WO2017089895A1 ADC57 |
Alpha-amanitin |
DNA-directed RNA polymerase II subunit RPB2 (POLR2B); DNA-directed RNA polymerase III subunit RPC7 (POLR3G) |
WO2017089895A1_ADC57 linker |
[151] | |
WO2017089895A1 ADC58 |
Alpha-amanitin+Monomethyl auristatin F |
Undisclosed |
WO2017089895A1_ADC58 linker |
[151] | |
WO2017089895A1 ADC59 |
Alpha-amanitin+Monomethyl auristatin F |
Undisclosed |
WO2017089895A1_ADC59 linker |
[151] | |
HER2-B Antibody-Compound (X) |
HER2-B Antibody-Compound (X) payload |
Undisclosed |
HER2-B Antibody-Compound (X) linker |
[53] | |
HER2-B Antibody-Compound (XI) |
HER2-B Antibody-Compound (XI) payload |
Undisclosed |
HER2-B Antibody-Compound (XI) linker |
[53] | |
HER2-B Antibody-Compound (XIV) |
HER2-B Antibody-Compound (XIV) payload |
Undisclosed |
HER2-B Antibody-Compound (XIV) linker |
[53] | |
HER2-B Antibody-Compound (XVIII) |
HER2-B Antibody-Compound (XVIII) payload |
Undisclosed |
HER2-B Antibody-Compound (XVIII) linker |
[53] | |
HER2-B Antibody-Compound (Ie) |
HER2-B Antibody-Compound (Ie) payload |
Undisclosed |
HER2-B Antibody-Compound (Ie) linker |
[53] | |
HER2-B Antibody-Compound (XIX) |
HER2-B Antibody-Compound (XIX) payload |
Undisclosed |
HER2-B Antibody-Compound (XIX) linker |
[53] | |
HER2-B Antibody-Compound (Ii) |
HER2-B Antibody-Compound (Ii) payload |
Undisclosed |
HER2-B Antibody-Compound (Ii) linker |
[53] | |
HER2-B Antibody-Compound (XLI) |
HER2-B Antibody-Compound (XLI) payload |
Undisclosed |
HER2-B Antibody-Compound (XLI) linker |
[53] | |
HER2-B Antibody-Compound (XVI) |
HER2-B Antibody-Compound (XIX) payload |
Undisclosed |
HER2-B Antibody-Compound (XIX) linker |
[53] | |
HER2-B Antibody-Compound (XL) |
HER2-B Antibody-Compound (XL) payload |
Undisclosed |
HER2-B Antibody-Compound (XL) linker |
[53] | |
HER2-B Antibody-Compound (XLIII) |
HER2-B Antibody-Compound (XLIII) payload |
Undisclosed |
HER2-B Antibody-Compound (XLIII) linker |
[53] | |
HER2-B Antibody-Compound (XLII) |
HER2-B Antibody-Compound (XLII) payload |
Undisclosed |
HER2-B Antibody-Compound (XLII) linker |
[53] | |
Trastuzumab-Compound (XV) |
Trastuzumab-Compound (XV) payload |
Undisclosed |
Trastuzumab-Compound (XV) linker |
[53] | |
WO2013055987A1 Tmab-101 |
SG2000 |
Human Deoxyribonucleic acid (hDNA) |
WO2013055987A1_Tmab-101 linker |
[152] | |
WO2013055987A1 Tmab-102 |
SG2000 |
Human Deoxyribonucleic acid (hDNA) |
WO2013055987A1_Tmab-102 linker |
[152] | |
WO2013055987A1 Tmab-104 |
SG2000 |
Human Deoxyribonucleic acid (hDNA) |
WO2013055987A1_Tmab-104 linker |
[152] | |
WO2013055987A1 Tmab-110 |
SG2000 |
Human Deoxyribonucleic acid (hDNA) |
WO2013055987A1_Tmab-110 linker |
[152] | |
WO2014159981A2 ADC-110 |
WO2014159981A2_ADC-110 payload |
Undisclosed |
WO2014159981A2_ADC-110 linker |
[97] | |
WO2014159981A2 ADC-120 |
WO2014159981A2_ADC-120 payload |
Undisclosed |
WO2014159981A2_ADC-120 linker |
[97] | |
ADC-II-1 |
ADC-II-1 payload |
Undisclosed |
ADC-II-1 linker |
[153] | |
ADC-II-5 |
ADC-II-5 payload |
Undisclosed |
ADC-II-5 linker |
[153] | |
ADC-II-9 |
ADC-II-9 payload |
Undisclosed |
ADC-II-9 linker |
[153] | |
ADC-II-13 |
ADC-II-13 payload |
Undisclosed |
ADC-II-13 linker |
[153] | |
ADC-I-1 |
ADC-I-1 payload |
Undisclosed |
ADC-I-1 linker |
[153] | |
ADC-III-1 |
ADC-III-1 payload |
Undisclosed |
ADC-III-1 linker |
[153] | |
ADC-III-9 |
ADC-III-9 payload |
Undisclosed |
ADC-III-9 linker |
[153] | |
WO2022078260A1 ADC-1 |
Ln-D9 |
DNA topoisomerase 1 (TOP1) |
WO2022078260A1_ADC-1 linker |
[154] | |
WO2022078260A1 ADC-2 |
Ln-D1 |
DNA topoisomerase 1 (TOP1) |
WO2022078260A1_ADC-2 linker |
[154] | |
WO2022078260A1 ADC-3 |
Ln-D2 |
DNA topoisomerase 1 (TOP1) |
WO2022078260A1_ADC-3 linker |
[154] | |
WO2022078260A1 ADC-4 |
Ln-D4 |
DNA topoisomerase 1 (TOP1) |
WO2022078260A1_ADC-4 linker |
[154] | |
WO2022078260A1 ADC-5 |
Ln-D5 |
DNA topoisomerase 1 (TOP1) |
WO2022078260A1_ADC-5 linker |
[154] | |
WO2022078260A1 ADC-6 |
Ln-D6 |
DNA topoisomerase 1 (TOP1) |
WO2022078260A1_ADC-6 linker |
[154] | |
WO2022078260A1 ADC-7 |
Ln-D7 |
DNA topoisomerase 1 (TOP1) |
WO2022078260A1_ADC-7 linker |
[154] | |
WO2022078260A1 ADC-8 |
Ln-D8 |
DNA topoisomerase 1 (TOP1) |
WO2022078260A1_ADC-8 linker |
[154] | |
WO2021249228A1 ADC-1 |
WO2021249228A1_ADC-1 payload |
Undisclosed |
WO2021249228A1_ADC-1 linker |
[155] | |
WO2021249228A1 ADC-2 |
WO2021249228A1_ADC-2 payload |
Undisclosed |
WO2021249228A1_ADC-2 linker |
[155] | |
WO2021249228A1 ADC-3 |
WO2021249228A1_ADC-3 payload |
Undisclosed |
WO2021249228A1_ADC-3 linker |
[155] | |
WO2021249228A1 ADC-4 |
WO2021249228A1_ADC-4 payload |
Undisclosed |
WO2021249228A1_ADC-4 linker |
[155] | |
WO2021249228A1 ADC-5 |
WO2021249228A1_ADC-5 payload |
Undisclosed |
WO2021249228A1_ADC-5 linker |
[155] | |
WO2021249228A1 ADC-6 |
WO2021249228A1_ADC-6 payload |
Undisclosed |
WO2021249228A1_ADC-6 linker |
[155] | |
WO2021249228A1 ADC-7 |
WO2021249228A1_ADC-7 payload |
Undisclosed |
WO2021249228A1_ADC-7 linker |
[155] | |
WO2021249228A1 ADC-8 |
WO2021249228A1_ADC-8 payload |
Undisclosed |
WO2021249228A1_ADC-8 linker |
[155] | |
WO2021249228A1 ADC-9 |
WO2021249228A1_ADC-9 payload |
Undisclosed |
WO2021249228A1_ADC-9 linker |
[155] | |
WO2021249228A1 ADC-10 |
WO2021249228A1_ADC-10 payload |
Undisclosed |
WO2021249228A1_ADC-10 linker |
[155] | |
WO2021249228A1 ADC-11 |
WO2021249228A1_ADC-11 payload |
Undisclosed |
WO2021249228A1_ADC-11 linker |
[155] | |
WO2021249228A1 ADC-12 |
WO2021249228A1_ADC-12 payload |
Undisclosed |
WO2021249228A1_ADC-12 linker |
[155] | |
WO2021249228A1 ADC-13 |
WO2021249228A1_ADC-13 payload |
Undisclosed |
WO2021249228A1_ADC-13 linker |
[155] | |
WO2021249228A1 ADC-14 |
WO2021249228A1_ADC-14 payload |
Undisclosed |
WO2021249228A1_ADC-14 linker |
[155] | |
WO2021249228A1 ADC-15 |
WO2021249228A1_ADC-15 payload |
Undisclosed |
WO2021249228A1_ADC-15 linker |
[155] | |
WO2021249228A1 ADC-16 |
WO2021249228A1_ADC-16 payload |
Undisclosed |
WO2021249228A1_ADC-16 linker |
[155] | |
WO2021249228A1 ADC-17 |
WO2021249228A1_ADC-17 payload |
Undisclosed |
WO2021249228A1_ADC-17 linker |
[155] | |
WO2021249228A1 ADC-18 |
WO2021249228A1_ADC-18 payload |
Undisclosed |
WO2021249228A1_ADC-18 linker |
[155] | |
WO2021249228A1 ADC-19 |
WO2021249228A1_ADC-19 payload |
Undisclosed |
WO2021249228A1_ADC-19 linker |
[155] | |
WO2021249228A1 ADC-20 |
WO2021249228A1_ADC-20 payload |
Undisclosed |
WO2021249228A1_ADC-20 linker |
[155] | |
WO2021249228A1 ADC-21 |
WO2021249228A1_ADC-21 payload |
Undisclosed |
WO2021249228A1_ADC-21 linker |
[155] | |
WO2021249228A1 ADC-22 |
WO2021249228A1_ADC-22 payload |
Undisclosed |
WO2021249228A1_ADC-22 linker |
[155] | |
WO2021249228A1 ADC-23 |
WO2021249228A1_ADC-23 payload |
Undisclosed |
WO2021249228A1_ADC-23 linker |
[155] | |
WO2021249228A1 ADC-24 |
WO2021249228A1_ADC-24 payload |
Undisclosed |
WO2021249228A1_ADC-24 linker |
[155] | |
WO2021249228A1 ADC-25 |
WO2021249228A1_ADC-25 payload |
Undisclosed |
WO2021249228A1_ADC-25 linker |
[155] | |
WO2021249228A1 ADC-26 |
WO2021249228A1_ADC-26 payload |
Undisclosed |
WO2021249228A1_ADC-26 linker |
[155] | |
WO2021249228A1 ADC-27 |
WO2021249228A1_ADC-27 payload |
Undisclosed |
WO2021249228A1_ADC-27 linker |
[155] | |
WO2021249228A1 ADC-28 |
WO2021249228A1_ADC-28 payload |
Undisclosed |
WO2021249228A1_ADC-28 linker |
[155] | |
WO2021249228A1 ADC-29 |
WO2021249228A1_ADC-29 payload |
Undisclosed |
WO2021249228A1_ADC-29 linker |
[155] | |
WO2021249228A1 ADC-30 |
WO2021249228A1_ADC-30 payload |
Undisclosed |
WO2021249228A1_ADC-30 linker |
[155] | |
WO2021249228A1 ADC-31 |
WO2021249228A1_ADC-31 payload |
Undisclosed |
WO2021249228A1_ADC-31 linker |
[155] | |
WO2021249228A1 ADC-32 |
WO2021249228A1_ADC-32 payload |
Undisclosed |
WO2021249228A1_ADC-32 linker |
[155] | |
WO2021249228A1 ADC-33 |
WO2021249228A1_ADC-33 payload |
Undisclosed |
WO2021249228A1_ADC-33 linker |
[155] | |
WO2021249228A1 ADC-34 |
WO2021249228A1_ADC-34 payload |
Undisclosed |
WO2021249228A1_ADC-34 linker |
[155] | |
WO2021249228A1 ADC-35 |
WO2021249228A1_ADC-35 payload |
Undisclosed |
WO2021249228A1_ADC-35 linker |
[155] | |
WO2021249228A1 ADC-36 |
WO2021249228A1_ADC-36 payload |
Undisclosed |
WO2021249228A1_ADC-36 linker |
[155] | |
WO2021249228A1 ADC-37 |
WO2021249228A1_ADC-37 payload |
Undisclosed |
WO2021249228A1_ADC-37 linker |
[155] | |
WO2021249228A1 ADC-38 |
WO2021249228A1_ADC-38 payload |
Undisclosed |
WO2021249228A1_ADC-38 linker |
[155] | |
WO2021249228A1 ADC-39 |
WO2021249228A1_ADC-39 payload |
Undisclosed |
WO2021249228A1_ADC-39 linker |
[155] | |
WO2021249228A1 ADC-40 |
WO2021249228A1_ADC-40 payload |
Undisclosed |
WO2021249228A1_ADC-40 linker |
[155] | |
WO2021249228A1 ADC-41 |
WO2021249228A1_ADC-41 payload |
Undisclosed |
WO2021249228A1_ADC-41 linker |
[155] | |
WO2021249228A1 ADC-42 |
WO2021249228A1_ADC-42 payload |
Undisclosed |
WO2021249228A1_ADC-42 linker |
[155] | |
WO2021249228A1 ADC-43 |
WO2021249228A1_ADC-43 payload |
Undisclosed |
WO2021249228A1_ADC-43 linker |
[155] | |
WO2021249228A1 ADC-44 |
WO2021249228A1_ADC-44 payload |
Undisclosed |
WO2021249228A1_ADC-44 linker |
[155] | |
WO2021249228A1 ADC-45 |
WO2021249228A1_ADC-45 payload |
Undisclosed |
WO2021249228A1_ADC-45 linker |
[155] | |
WO2021249228A1 ADC-46 |
WO2021249228A1_ADC-46 payload |
Undisclosed |
WO2021249228A1_ADC-46 linker |
[155] | |
WO2021249228A1 ADC-47 |
WO2021249228A1_ADC-47 payload |
Undisclosed |
WO2021249228A1_ADC-47 linker |
[155] | |
WO2021249228A1 ADC-48 |
WO2021249228A1_ADC-48 payload |
Undisclosed |
WO2021249228A1_ADC-48 linker |
[155] | |
WO2021249228A1 ADC-49 |
WO2021249228A1_ADC-49 payload |
Undisclosed |
WO2021249228A1_ADC-49 linker |
[155] | |
WO2021249228A1 ADC-50 |
WO2021249228A1_ADC-50 payload |
Undisclosed |
WO2021249228A1_ADC-50 linker |
[155] | |
WO2021249228A1 ADC-51 |
WO2021249228A1_ADC-51 payload |
Undisclosed |
WO2021249228A1_ADC-51 linker |
[155] | |
WO2021249228A1 ADC-52 |
WO2021249228A1_ADC-52 payload |
Undisclosed |
WO2021249228A1_ADC-52 linker |
[155] | |
WO2021249228A1 ADC-53 |
WO2021249228A1_ADC-53 payload |
Undisclosed |
WO2021249228A1_ADC-53 linker |
[155] | |
WO2021249228A1 ADC-54 |
WO2021249228A1_ADC-54 payload |
Undisclosed |
WO2021249228A1_ADC-54 linker |
[155] | |
WO2021249228A1 ADC-55 |
WO2021249228A1_ADC-55 payload |
Undisclosed |
WO2021249228A1_ADC-55 linker |
[155] | |
WO2021249228A1 ADC-56 |
WO2021249228A1_ADC-56 payload |
Undisclosed |
WO2021249228A1_ADC-56 linker |
[155] | |
WO2021249228A1 ADC-57 |
WO2021249228A1_ADC-57 payload |
Undisclosed |
WO2021249228A1_ADC-57 linker |
[155] | |
WO2021249228A1 ADC-58 |
WO2021249228A1_ADC-58 payload |
Undisclosed |
WO2021249228A1_ADC-58 linker |
[155] | |
WO2021249228A1 ADC-59 |
WO2021249228A1_ADC-59 payload |
Undisclosed |
WO2021249228A1_ADC-59 linker |
[155] | |
WO2021249228A1 ADC-60 |
WO2021249228A1_ADC-60 payload |
Undisclosed |
WO2021249228A1_ADC-60 linker |
[155] | |
WO2021249228A1 ADC-61 |
WO2021249228A1_ADC-61 payload |
Undisclosed |
WO2021249228A1_ADC-61 linker |
[155] | |
WO2022228495A1 ADC-67 |
WO2022228495A1 ADC-67 payload |
Undisclosed |
WO2022228495A1 ADC-67 linker |
[50] | |
WO2022228495A1 ADC-68 |
WO2022228495A1 ADC-68 payload |
Undisclosed |
WO2022228495A1 ADC-68 linker |
[50] | |
WO2022228495A1 ADC-69 |
WO2022228495A1 ADC-69 payload |
Undisclosed |
WO2022228495A1 ADC-69 linker |
[50] | |
WO2022228495A1 ADC-70 |
WO2022228495A1 ADC-70 payload |
Undisclosed |
WO2022228495A1 ADC-70 linker |
[50] | |
WO2022228495A1 ADC-71 |
WO2022228495A1 ADC-71 payload |
Undisclosed |
WO2022228495A1 ADC-71 linker |
[50] | |
WO2022228495A1 ADC-74 |
WO2022228495A1 ADC-74 payload |
Undisclosed |
WO2022228495A1 ADC-74 linker |
[50] | |
WO2022228495A1 ADC-75 |
WO2022228495A1 ADC-75 payload |
Undisclosed |
WO2022228495A1 ADC-75 linker |
[50] | |
HER2-MMAU ADC |
Glucuronyl-monomethyl-auristatin E (MMAU) |
Microtubule (MT) |
Mc-Val-Cit-PABC |
[156] | |
PF-06888667 |
SW-163D |
Human Deoxyribonucleic acid (hDNA) |
AcLys-Val-Cit-PABC-DMAE |
[157] | |
TTZ-1-MMAE |
Monomethyl auristatin E |
Microtubule (MT) |
DSPh-Val-Ala-PABC |
[158] | |
TTZ-2-MMAE |
Monomethyl auristatin E |
Microtubule (MT) |
DSPh-Val-Cit-PABC |
[158] | |
TTZ-3-MMAE |
Monomethyl auristatin E |
Microtubule (MT) |
DSPh-PEG12-Val-Ala-PABC |
[158] | |
TTZ-4-MMAE |
Monomethyl auristatin E |
Microtubule (MT) |
DSPh-PEG12-Val-Cit-PABC |
[158] | |
Trastuzumab-DVP-linker-MMAE 1 |
Monomethyl auristatin E |
Microtubule (MT) |
DVP-based linker 1f |
[159] | |
Trastuzumab-Val-Cit linker-MMAE 2 |
Monomethyl auristatin E |
Microtubule (MT) |
Val-Cit linker 2e |
[159] | |
Trastuzumab-DVP-linker-MMAE 3 |
Monomethyl auristatin E |
Microtubule (MT) |
DVP-based linker 3 |
[159] | |
Trastuzumab-DVP-linker-MMAE 4 |
Monomethyl auristatin E |
Microtubule (MT) |
DVP-based linker 4 |
[159] | |
Trastuzumab-Me-PRX conjugate |
Methylated-beta-Cyclodextrin/Pluronic P103-based polyrotaxane (Me-PRX) |
Undisclosed |
Phenyl maleimide PEG2 |
[160] | |
HER2-acetal-ADC 11 |
Monomethyl auristatin F |
Microtubule (MT) |
Clravable-acetal based linker 11 |
[161] | |
HER2-acetal-ADC 12 |
Monomethyl auristatin F |
Microtubule (MT) |
Clravable-TAMRA-acetal based linker 12 |
[161] | |
HER2-azide-alkyne MMAE conjugate |
Monomethyl auristatin E |
Microtubule (MT) |
Azide-alkyne based linker 10a |
[162] | |
HER2-cyclopropene-tetrazine MMAE conjugate |
Monomethyl auristatin E |
Microtubule (MT) |
Cyclopropene-tetrazine based linker 10b |
[162] | |
HER2-norbornene-tetrazine MMAE conjugate |
Monomethyl auristatin E |
Microtubule (MT) |
Norbornene-tetrazine based linker 10c |
[162] | |
T-FcBP-DM1 |
Mertansine DM1 |
Microtubule (MT) |
N-terminal norbornene group pFcBP linker |
[163] | |
T-D8-1508 |
AZ-1508 |
Microtubule (MT) |
Cysteine D8 |
[164] | |
T-D6-1508 |
AZ-1508 |
Microtubule (MT) |
Cysteine D6 |
[164] | |
T-D4-1508 |
AZ-1508 |
Microtubule (MT) |
Cysteine D4 |
[164] | |
T-D2-1508 |
AZ-1508 |
Microtubule (MT) |
Cysteine D2 |
[164] | |
HER2 ADC-18 |
Monomethyl auristatin E |
Microtubule (MT) |
Vinylsulfonamide based linker 15 |
[165] | |
HER2 ADC-19 |
Monomethyl auristatin E |
Microtubule (MT) |
Vinylsulfonamide based linker 16 |
[165] | |
HER2 ADC-20 |
Monomethyl auristatin E |
Microtubule (MT) |
Vinylsulfonamide based linker 17 |
[165] | |
T-DM1-IR700 |
Mertansine DM1 plus IRDye700DX |
Microtubule (MT) |
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC) |
[166] | |
HER2-gsADC-46 |
Monomethyl auristatin E |
Microtubule (MT) |
ThioPz linker 6a |
[36] | |
HER2-gsADC-47 |
Monomethyl auristatin E |
Microtubule (MT) |
Hydroxylamine derivative 6c |
[36] | |
HER2-gsADC-48 |
Monomethyl auristatin E |
Microtubule (MT) |
2-Aminobenzamide oxime |
[36] | |
HER2-gsADC-49 |
Monomethyl auristatin E |
Microtubule (MT) |
Azadibenzocylooctyne-amine derivative 6d |
[36] | |
HER2-gsADC-50 |
Monomethyl auristatin E |
Microtubule (MT) |
2-Aminobenzamidoxime without core-fucosylation |
[36] | |
T-DM1-2.6 |
Mertansine DM1 |
Microtubule (MT) |
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC) |
[36] | |
Trastuzumab-amanitin 1 |
Beta-amanitin |
DNA-directed RNA polymerase II subunit RPB2 (POLR2B); DNA-directed RNA polymerase III subunit RPC7 (POLR3G) |
Trastuzumab-Amanitin1 linker |
[167] | |
Trastuzumab-alpha-amanitin conjugate 3 |
Alpha-amanitin |
DNA-directed RNA polymerase II subunit RPB2 (POLR2B); DNA-directed RNA polymerase III subunit RPC7 (POLR3G) |
Trastuzumab-alpha-amanitin conjugate 3 linker |
[167] | |
Trastuzumab-alpha-amanitin conjugate 4 |
Alpha-amanitin |
DNA-directed RNA polymerase II subunit RPB2 (POLR2B); DNA-directed RNA polymerase III subunit RPC7 (POLR3G) |
Trastuzumab-alpha-amanitin conjugate 4 linker |
[167] | |
Trastuzumab-alpha-amanitin conjugate 7 |
Alpha-amanitin |
DNA-directed RNA polymerase II subunit RPB2 (POLR2B); DNA-directed RNA polymerase III subunit RPC7 (POLR3G) |
Trastuzumab-alpha-amanitin conjugate 7 linker |
[167] | |
Trastuzumab-alpha-amanitin conjugate 10 |
Alpha-amanitin |
DNA-directed RNA polymerase II subunit RPB2 (POLR2B); DNA-directed RNA polymerase III subunit RPC7 (POLR3G) |
Trastuzumab-alpha-amanitin conjugate 10 linker |
[167] | |
Trastuzumab-alpha-amanitin conjugate 11 |
Alpha-amanitin |
DNA-directed RNA polymerase II subunit RPB2 (POLR2B); DNA-directed RNA polymerase III subunit RPC7 (POLR3G) |
Trastuzumab-alpha-amanitin conjugate 11 linker |
[167] | |
Trastuzumab-alpha-amanitin conjugate 14 |
Alpha-amanitin |
DNA-directed RNA polymerase II subunit RPB2 (POLR2B); DNA-directed RNA polymerase III subunit RPC7 (POLR3G) |
Trastuzumab-alpha-amanitin conjugate 14 linker |
[167] | |
Trastuzumab-alpha-amanitin conjugate 15 |
Alpha-amanitin |
DNA-directed RNA polymerase II subunit RPB2 (POLR2B); DNA-directed RNA polymerase III subunit RPC7 (POLR3G) |
Trastuzumab-alpha-amanitin conjugate 15 linker |
[167] | |
Trastuzumab-amanitin 3 |
Beta-amanitin |
DNA-directed RNA polymerase II subunit RPB2 (POLR2B); DNA-directed RNA polymerase III subunit RPC7 (POLR3G) |
Trastuzumab-Amanitin3 linker |
[167] | |
Trastuzumab-amanitin 4 |
Beta-amanitin |
DNA-directed RNA polymerase II subunit RPB2 (POLR2B); DNA-directed RNA polymerase III subunit RPC7 (POLR3G) |
Trastuzumab-Amanitin4 linker |
[167] | |
Her-30.0643 |
HDP 30.0643 |
DNA-directed RNA polymerase II subunit RPB2 (POLR2B); DNA-directed RNA polymerase III subunit RPC7 (POLR3G) |
Her-30.0643 linker |
[168] | |
Her-30.1033 |
HDP 30.1033 |
Undisclosed |
Her-30.1033 linker |
[168] | |
Her-30.1036 |
HDP 30.1036 |
Undisclosed |
Her-30.1036 linker |
[168] | |
Her-30.1165 |
HDP 30.1165 |
Undisclosed |
Her-30.1165 linker |
[168] | |
Her-30.0132 |
HDP 30.0132 |
Undisclosed |
Her-30.0132 linker |
[168] | |
Her-30.0134 |
HDP 30.0134 |
Undisclosed |
Her-30.0134 linker |
[168] | |
Her-30.0741 |
HDP 30.0741 |
Undisclosed |
Her-30.0741 linker |
[168] | |
Her-30.0743 |
HDP 30.0743 |
Undisclosed |
Her-30.0743 linker |
[168] | |
Trastuzumab-E-13 |
Trastuzumab-E-13 payload |
Undisclosed |
Trastuzumab-E-13 linker |
[169] | |
Trastuzumab-G-13 |
Trastuzumab-G-13 payload |
Undisclosed |
Trastuzumab-G-13 linker |
[169] | |
Trastuzumab-E-11 |
Trastuzumab-E-11 payload |
Undisclosed |
Trastuzumab-E-11 linker |
[169] | |
Trastuzumab-E-12 |
Trastuzumab-E-12 payload |
Undisclosed |
Trastuzumab-E-12 payload |
[169] | |
Trastuzumab-G-12 |
Trastuzumab-G-12 payload |
Undisclosed |
Trastuzumab-G-12E-11 |
[169] | |
Trastuzumab-F-13 |
Trastuzumab-F-13 payload |
Undisclosed |
Trastuzumab-F-13E-12 |
[169] | |
Trastuzumab-E-15 |
Trastuzumab-E-15 payload |
Undisclosed |
Trastuzumab-E-15G-12 |
[169] | |
Trastuzumab-G-15 |
Trastuzumab-G-15 payload |
Undisclosed |
Trastuzumab-G-15F-13 |
[169] | |
Trastuzumab-F-61 |
Trastuzumab-F-61 payload |
Undisclosed |
Trastuzumab-F-61E-15 |
[169] | |
Trastuzumab-F-62 |
Trastuzumab-F-62 payload |
Undisclosed |
Trastuzumab-F-62G-15 |
[169] | |
Trastuzumab-F-63 |
Trastuzumab-F-63 payload |
Undisclosed |
Trastuzumab-F-63F-61 |
[169] | |
WO2017089890A1 ADC1 |
Monomethyl auristatin E |
Microtubule (MT) |
WO2017089890A1_ADC1 linker |
[170] | |
WO2017089890A1 ADC2 |
Monomethyl auristatin F |
Microtubule (MT) |
WO2017089890A1_ADC2 linker |
[170] | |
WO2017089890A1 ADC3 |
Monomethyl auristatin E |
Microtubule (MT) |
WO2017089890A1_ADC3 linker |
[170] | |
WO2017089890A1 ADC4 |
Monomethyl auristatin F |
Microtubule (MT) |
WO2017089890A1_ADC4 linker |
[170] | |
WO2017089890A1 ADC5 |
Monomethyl auristatin E |
Microtubule (MT) |
WO2017089890A1_ADC5 linker |
[170] | |
WO2017089890A1 ADC6 |
Monomethyl auristatin F |
Microtubule (MT) |
WO2017089890A1_ADC6 linker |
[170] | |
WO2017089890A1 ADC7 |
Monomethyl auristatin E |
Microtubule (MT) |
WO2017089890A1_ADC7 linker |
[170] | |
WO2017089890A1 ADC8 |
Monomethyl auristatin F |
Microtubule (MT) |
WO2017089890A1_ADC8 linker |
[170] | |
WO2017089890A1 ADC9 |
Monomethyl auristatin E |
Microtubule (MT) |
WO2017089890A1_ADC9 linker |
[170] | |
WO2017089890A1 ADC10 |
Monomethyl auristatin E |
Microtubule (MT) |
WO2017089890A1_ADC10 linker |
[170] | |
WO2017089890A1 ADC11 |
Monomethyl auristatin E |
Microtubule (MT) |
WO2017089890A1_ADC11 linker |
[170] | |
WO2017089890A1 ADC12 |
Monomethyl auristatin E |
Microtubule (MT) |
WO2017089890A1_ADC12 linker |
[170] | |
WO2017089890A1 ADC13 |
Monomethyl auristatin E |
Microtubule (MT) |
WO2017089890A1_ADC13 linker |
[170] | |
WO2017089890A1 ADC14 |
Monomethyl auristatin F |
Microtubule (MT) |
WO2017089890A1_ADC14 linker |
[170] | |
WO2017089890A1 ADC15 |
Monomethyl auristatin E |
Microtubule (MT) |
WO2017089890A1_ADC15 linker |
[170] | |
WO2017089890A1 ADC16 |
Monomethyl auristatin F |
Microtubule (MT) |
WO2017089890A1_ADC16 linker |
[170] | |
WO2017089890A1 ADC17 |
Monomethyl auristatin E |
Microtubule (MT) |
WO2017089890A1_ADC17 linker |
[170] | |
WO2017089890A1 ADC18 |
Monomethyl auristatin F |
Microtubule (MT) |
WO2017089890A1_ADC18 linker |
[170] | |
WO2017089890A1 ADC19 |
Monomethyl auristatin E |
Microtubule (MT) |
WO2017089890A1_ADC19 linker |
[170] | |
WO2017089890A1 ADC20 |
Monomethyl auristatin F |
Microtubule (MT) |
WO2017089890A1_ADC20 linker |
[170] | |
WO2017089890A1 ADC86 |
Monomethyl auristatin F |
Microtubule (MT) |
WO2017089890A1_ADC86 linker |
[170] | |
WO2017089890A1 ADC87 |
Monomethyl auristatin E |
Microtubule (MT) |
WO2017089890A1_ADC87 linker |
[170] | |
WO2017089890A1 ADC23 |
Monomethyl auristatin F |
Microtubule (MT) |
WO2017089890A1_ADC23 linker |
[170] | |
WO2017089890A1 ADC24 |
Monomethyl auristatin E |
Microtubule (MT) |
WO2017089890A1_ADC24 linker |
[170] | |
WO2017089890A1 ADC25 |
Monomethyl auristatin E |
Microtubule (MT) |
WO2017089890A1_ADC25 linker |
[170] | |
WO2017089890A1 ADC26 |
Monomethyl auristatin E |
Microtubule (MT) |
WO2017089890A1_ADC26 linker |
[170] | |
WO2017089890A1 ADC27 |
Monomethyl auristatin E |
Microtubule (MT) |
WO2017089890A1_ADC27 linker |
[170] | |
WO2017089890A1 ADC28 |
Monomethyl auristatin E |
Microtubule (MT) |
WO2017089890A1_ADC28 linker |
[170] | |
WO2017089890A1 ADC29 |
Monomethyl auristatin E |
Microtubule (MT) |
WO2017089890A1_ADC29 linker |
[170] | |
WO2017089890A1 ADC30 |
Monomethyl auristatin E |
Microtubule (MT) |
WO2017089890A1_ADC30 linker |
[170] | |
WO2017089890A1 ADC31 |
Monomethyl auristatin E |
Microtubule (MT) |
WO2017089890A1_ADC31 linker |
[170] | |
WO2017089890A1 ADC32 |
Monomethyl auristatin E |
Microtubule (MT) |
WO2017089890A1_ADC32 linker |
[170] | |
WO2017089890A1 ADC33 |
Monomethyl auristatin E |
Microtubule (MT) |
WO2017089890A1_ADC33 linker |
[170] | |
WO2017089890A1 ADC34 |
Monomethyl auristatin F |
Microtubule (MT) |
WO2017089890A1_ADC34 linker |
[170] | |
WO2017089890A1 ADC35 |
Monomethyl auristatin E |
Microtubule (MT) |
WO2017089890A1_ADC35 linker |
[170] | |
WO2017089890A1 ADC36 |
Monomethyl auristatin E |
Microtubule (MT) |
WO2017089890A1_ADC36 linker |
[170] | |
WO2017089890A1 ADC37 |
Monomethyl auristatin E |
Microtubule (MT) |
WO2017089890A1_ADC37 linker |
[170] | |
WO2017089890A1 ADC38 |
Monomethyl auristatin F |
Microtubule (MT) |
WO2017089890A1_ADC38 linker |
[170] | |
WO2017089890A1 ADC39 |
Monomethyl auristatin E |
Microtubule (MT) |
WO2017089890A1_ADC39 linker |
[170] | |
WO2017089890A1 ADC40 |
Monomethyl auristatin F |
Microtubule (MT) |
WO2017089890A1_ADC40 linker |
[170] | |
WO2017089890A1 ADC41 |
Monomethyl auristatin E |
Microtubule (MT) |
WO2017089890A1_ADC41 linker |
[170] | |
WO2017089890A1 ADC42 |
Monomethyl auristatin F |
Microtubule (MT) |
WO2017089890A1_ADC42 linker |
[170] | |
WO2017089890A1 ADC43 |
Monomethyl auristatin E |
Microtubule (MT) |
WO2017089890A1_ADC43 linker |
[170] | |
WO2017089890A1 ADC44 |
Monomethyl auristatin F |
Microtubule (MT) |
WO2017089890A1_ADC44 linker |
[170] | |
WO2017089890A1 ADC45 |
Monomethyl auristatin E |
Microtubule (MT) |
WO2017089890A1_ADC45 linker |
[170] | |
WO2017089890A1 ADC46 |
Monomethyl auristatin F |
Microtubule (MT) |
WO2017089890A1_ADC46 linker |
[170] | |
WO2017089890A1 ADC47 |
Monomethyl auristatin E |
Microtubule (MT) |
WO2017089890A1_ADC47 linker |
[170] | |
WO2017089890A1 ADC48 |
Monomethyl auristatin F |
Microtubule (MT) |
WO2017089890A1_ADC48 linker |
[170] | |
WO2017089890A1 ADC49 |
Monomethyl auristatin E |
Microtubule (MT) |
WO2017089890A1_ADC49 linker |
[170] | |
WO2017089890A1 ADC50 |
Monomethyl auristatin F |
Microtubule (MT) |
WO2017089890A1_ADC50 linker |
[170] | |
WO2017089890A1 ADC51 |
Monomethyl auristatin E |
Microtubule (MT) |
WO2017089890A1_ADC51 linker |
[170] | |
WO2017089890A1 ADC52 |
Monomethyl auristatin E |
Microtubule (MT) |
WO2017089890A1_ADC52 linker |
[170] | |
WO2017089890A1 ADC53 |
Monomethyl auristatin E |
Microtubule (MT) |
WO2017089890A1_ADC53 linker |
[170] | |
WO2017089890A1 ADC54 |
Monomethyl auristatin F |
Microtubule (MT) |
WO2017089890A1_ADC54 linker |
[170] | |
WO2017089890A1 ADC55 |
Monomethyl auristatin E |
Microtubule (MT) |
WO2017089890A1_ADC55 linker |
[170] | |
WO2017089890A1 ADC76 |
Monomethyl auristatin F |
Microtubule (MT) |
WO2017089890A1_ADC76 linker |
[170] | |
WO2017089890A1 ADC88 |
Monomethyl auristatin F |
Microtubule (MT) |
WO2017089890A1_ADC88 linker |
[170] | |
WO2017089890A1 ADC89 |
Monomethyl auristatin E |
Microtubule (MT) |
WO2017089890A1_ADC89 linker |
[170] | |
WO2017089890A1 ADC90 |
Monomethyl auristatin F |
Microtubule (MT) |
WO2017089890A1_ADC90 linker |
[170] | |
WO2017089890A1 ADC91 |
Monomethyl auristatin E |
Microtubule (MT) |
WO2017089890A1_ADC91 linker |
[170] | |
WO2017089890A1 ADC60 |
Monomethyl auristatin F |
Microtubule (MT) |
WO2017089890A1_ADC60 linker |
[170] | |
WO2017089890A1 ADC61 |
Monomethyl auristatin E |
Microtubule (MT) |
WO2017089890A1_ADC61 linker |
[170] | |
WO2017089890A1 ADC62 |
Monomethyl auristatin F |
Microtubule (MT) |
WO2017089890A1_ADC62 linker |
[170] | |
WO2017089890A1 ADC63 |
Monomethyl auristatin E |
Microtubule (MT) |
WO2017089890A1_ADC63 linker |
[170] | |
WO2017089890A1 ADC77 |
Monomethyl auristatin F |
Microtubule (MT) |
WO2017089890A1_ADC77 linker |
[170] | |
WO2017089890A1 ADC21 |
Alpha-amanitin |
DNA-directed RNA polymerase II subunit RPB2 (POLR2B); DNA-directed RNA polymerase III subunit RPC7 (POLR3G) |
WO2017089890A1_ADC21 linker |
[170] | |
WO2017089890A1 ADC22 |
Alpha-amanitin |
DNA-directed RNA polymerase II subunit RPB2 (POLR2B); DNA-directed RNA polymerase III subunit RPC7 (POLR3G) |
WO2017089890A1_ADC22 linker |
[170] | |
WO2017089890A1 ADC56 |
Alpha-amanitin |
DNA-directed RNA polymerase II subunit RPB2 (POLR2B); DNA-directed RNA polymerase III subunit RPC7 (POLR3G) |
WO2017089890A1_ADC56 linker |
[170] | |
WO2017089890A1 ADC57 |
Alpha-amanitin |
DNA-directed RNA polymerase II subunit RPB2 (POLR2B); DNA-directed RNA polymerase III subunit RPC7 (POLR3G) |
WO2017089890A1_ADC57 linker |
[170] | |
WO2017089890A1 ADC58 |
Alpha-amanitin+Monomethyl auristatin E |
DNA-directed RNA polymerase II subunit RPB2 (POLR2B); DNA-directed RNA polymerase III subunit RPC7 (POLR3G); Microtubule (MT) |
WO2017089890A1_ADC58 linker |
[170] | |
WO2017089890A1 ADC59 |
Alpha-amanitin+Monomethyl auristatin E |
DNA-directed RNA polymerase II subunit RPB2 (POLR2B); DNA-directed RNA polymerase III subunit RPC7 (POLR3G); Microtubule (MT) |
WO2017089890A1_ADC59 linker |
[170] | |
WO2017089890A1 ADC78 |
Alpha-amanitin+Monomethyl auristatin E |
DNA-directed RNA polymerase II subunit RPB2 (POLR2B); DNA-directed RNA polymerase III subunit RPC7 (POLR3G); Microtubule (MT) |
WO2017089890A1_ADC78 linker |
[170] | |
WO2018098269A2 conjugate 25 |
WO2018098269A2_conjugate 25 payload |
Undisclosed |
WO2018098269A2_conjugate 25 linker |
[171] | |
WO2018098269A2 conjugate 28 |
WO2018098269A2_conjugate 28 payload |
Undisclosed |
WO2018098269A2_conjugate 28 linker |
[171] | |
WO2018098269A2 conjugate 31A |
WO2018098269A2_conjugate 31A payload |
Undisclosed |
WO2018098269A2_conjugate 31A linker |
[171] | |
WO2018098269A2 conjugate 34A |
WO2018098269A2_conjugate 34A payload |
Undisclosed |
WO2018098269A2_conjugate 34A linker |
[171] | |
WO2018098269A2 conjugate 43A |
WO2018098269A2_conjugate 43A payload |
Undisclosed |
WO2018098269A2_conjugate 43A linker |
[171] | |
WO2018098269A2 conjugate 46A |
WO2018098269A2_conjugate 46A payload |
Undisclosed |
WO2018098269A2_conjugate 46A linker |
[171] | |
WO2018098269A2 conjugate 48 |
WO2018098269A2_conjugate 48 payload |
Undisclosed |
WO2018098269A2_conjugate 48 linker |
[171] | |
WO2018098269A2 conjugate 50 |
WO2018098269A2_conjugate 50 payload |
Undisclosed |
WO2018098269A2_conjugate 50 linker |
[171] | |
WO2018098269A2 conjugate 52 |
WO2018098269A2_conjugate 52 payload |
Undisclosed |
WO2018098269A2_conjugate 52 linker |
[171] | |
WO2018098269A2 conjugate 67 |
WO2018098269A2_conjugate 67 payload |
Undisclosed |
WO2018098269A2_conjugate 67 linker |
[171] | |
WO2018098269A2 conjugate 68 |
WO2018098269A2_conjugate 68 payload |
Undisclosed |
WO2018098269A2_conjugate 68 linker |
[171] | |
WO2018098269A2 conjugate 46B |
WO2018098269A2_conjugate 46B payload |
Undisclosed |
WO2018098269A2_conjugate 46B linker |
[171] | |
WO2018098269A2 conjugate 43B |
WO2018098269A2_conjugate 43B payload |
Undisclosed |
WO2018098269A2_conjugate 43B linker |
[171] | |
WO2018098269A2 conjugate 34B |
WO2018098269A2_conjugate 34B payload |
Undisclosed |
WO2018098269A2_conjugate 34B linker |
[171] | |
WO2018098269A2 conjugate 31B |
WO2018098269A2_conjugate 31B payload |
Undisclosed |
WO2018098269A2_conjugate 31B linker |
[171] | |
WO2015004400A1 ADC-1 |
WO2015004400A1 ADC-1 payload |
Undisclosed |
WO2015004400A1 ADC-1 linker |
[172] | |
WO2015004400A1 ADC-2 |
WO2015004400A1 ADC-2 payload |
Undisclosed |
WO2015004400A1 ADC-2 linker |
[172] | |
WO2015004400A1 ADC-3 |
WO2015004400A1 ADC-3 payload |
Undisclosed |
WO2015004400A1 ADC-3 linker |
[172] | |
WO2015004400A1 ADC-4 |
WO2015004400A1 ADC-4 payload |
Undisclosed |
WO2015004400A1 ADC-4 linker |
[172] | |
WO2015004400A1 ADC-5 |
WO2015004400A1 ADC-5 payload |
Undisclosed |
WO2015004400A1 ADC-5 linker |
[172] | |
WO2015004400A1 ADC-6 |
WO2015004400A1 ADC-6 payload |
Undisclosed |
WO2015004400A1 ADC-6 linker |
[172] | |
WO2015004400A1 ADC-7 |
WO2015004400A1 ADC-7 payload |
Undisclosed |
WO2015004400A1 ADC-7 linker |
[172] | |
WO2015004400A1 ADC-8 |
WO2015004400A1 ADC-8 payload |
Undisclosed |
WO2015004400A1 ADC-8 linker |
[172] | |
Trastuzumab-Compound 9 |
Mertansine DM1 |
Microtubule (MT) |
Trastuzumab-Compound 9 linker |
[23] | |
Trastuzumab-Compound 17 |
Mertansine DM4 |
Microtubule (MT) |
Trastuzumab-Compound 17 linker |
[23] | |
Trastuzumab-Compound 25 |
Monomethyl auristatin E |
Microtubule (MT) |
Trastuzumab-Compound 25 linker |
[23] | |
Trastuzumab-Compound 31 |
Auristatin 0101 |
Microtubule (MT) |
Trastuzumab-Compound 31 linker |
[23] | |
Trastuzumab-Compound 36 |
Monomethyl auristatin E |
Microtubule (MT) |
Trastuzumab-Compound 36 linker |
[23] | |
Trastuzumab-Compound 43 |
PBD dimer |
Human Deoxyribonucleic acid (hDNA) |
Trastuzumab-Compound 43 linker |
[23] | |
Trastuzumab-Compound 49 |
PBD dimer |
Human Deoxyribonucleic acid (hDNA) |
Trastuzumab-Compound 49 linker |
[23] | |
Trastuzumab-Compound 55 |
Mertansine DM1 |
Microtubule (MT) |
Trastuzumab-Compound 55 linker |
[23] | |
Trastuzumab-Compound 59 |
Mertansine DM4 |
Microtubule (MT) |
Trastuzumab-Compound 59 linker |
[23] | |
Trastuzumab-Compound 64 |
Monomethyl auristatin E |
Microtubule (MT) |
Trastuzumab-Compound 64 linker |
[23] | |
Trastuzumab-Compound 69 |
Monomethyl auristatin E |
Microtubule (MT) |
Trastuzumab-Compound 69 linker |
[23] | |
Trastuzumab-Compound 74 |
PBD dimer |
Human Deoxyribonucleic acid (hDNA) |
Trastuzumab-Compound 74 linker |
[23] | |
Trastuzumab-Compound 75 |
Monomethyl auristatin E |
Microtubule (MT) |
Trastuzumab-Compound 75 linker |
[23] | |
Trastuzumab-Compound 76 |
Monomethyl auristatin E |
Microtubule (MT) |
Trastuzumab-Compound 76 linker |
[23] | |
Trastuzumab-Compound 77 |
Mertansine DM1 |
Microtubule (MT) |
Trastuzumab-Compound 77 linker |
[23] | |
Trastuzumab-Compound 78 |
Auristatin 0101 |
Microtubule (MT) |
Trastuzumab-Compound 78 linker |
[23] | |
Trastuzumab-Compound 79 |
Auristatin 0101 |
Microtubule (MT) |
Trastuzumab-Compound 79 linker |
[23] | |
Trastuzumab-Compound 80 |
Mertansine DM4 |
Microtubule (MT) |
Trastuzumab-Compound 80 linker |
[23] | |
CN114917361A ADC-2 |
CN114917361A ADC-2 payload |
Undisclosed |
CN114917361A ADC-2 linker |
[173] | |
CN114917361A ADC-7 |
CN114917361A ADC-7 payload |
Undisclosed |
CN114917361A ADC-7 linker |
[173] | |
CN114917361A ADC-14 |
CN114917361A ADC-14 payload |
Undisclosed |
CN114917361A ADC-14 linker |
[173] | |
CN114917361A ADC-17 |
CN114917361A ADC-17 payload |
Undisclosed |
CN114917361A ADC-17 linker |
[173] | |
CN114917361A ADC-22 |
CN114917361A ADC-22 payload |
Undisclosed |
CN114917361A ADC-22 linker |
[173] | |
CN114917361A ADC-28 |
CN114917361A ADC-28 payload |
Undisclosed |
CN114917361A ADC-28 linker |
[173] | |
CN114917361A ADC-31 |
CN114917361A ADC-31 payload |
Undisclosed |
CN114917361A ADC-31 linker |
[173] | |
CN114917361A ADC-34 |
CN114917361A ADC-34 payload |
Undisclosed |
CN114917361A ADC-34 linker |
[173] | |
CN114917361A ADC-37 |
CN114917361A ADC-37 payload |
Undisclosed |
CN114917361A ADC-37 linker |
[173] | |
CN114917361A ADC-42 |
CN114917361A ADC-42 payload |
Undisclosed |
CN114917361A ADC-42 linker |
[173] | |
CN114917361A ADC-45 |
CN114917361A ADC-45 payload |
Undisclosed |
CN114917361A ADC-45 linker |
[173] | |
CN114917361A ADC-48 |
CN114917361A ADC-48 payload |
Undisclosed |
CN114917361A ADC-48 linker |
[173] | |
CN114917361A ADC-51 |
CN114917361A ADC-51 payload |
Undisclosed |
CN114917361A ADC-51 linker |
[173] | |
CN114917361A ADC-56 |
CN114917361A ADC-56 payload |
Undisclosed |
CN114917361A ADC-56 linker |
[173] | |
CN114917361A ADC-59 |
CN114917361A ADC-59 payload |
Undisclosed |
CN114917361A ADC-59 linker |
[173] | |
CN114917361A ADC-62 |
CN114917361A ADC-62 payload |
Undisclosed |
CN114917361A ADC-62 linker |
[173] | |
CN114917361A ADC-65 |
CN114917361A ADC-65 payload |
Undisclosed |
CN114917361A ADC-65 linker |
[173] | |
CN114917361A ADC-68 |
CN114917361A ADC-68 payload |
Undisclosed |
CN114917361A ADC-68 linker |
[173] | |
CN114917361A ADC-71 |
CN114917361A ADC-71 payload |
Undisclosed |
CN114917361A ADC-71 linker |
[173] | |
CN114917361A ADC-74 |
CN114917361A ADC-74 payload |
Undisclosed |
CN114917361A ADC-74 linker |
[173] | |
CN114917361A ADC-77 |
CN114917361A ADC-77 payload |
Undisclosed |
CN114917361A ADC-77 linker |
[173] | |
CN114917361A ADC-80 |
CN114917361A ADC-80 payload |
Undisclosed |
CN114917361A ADC-80 linker |
[173] | |
CN114917361A ADC-83 |
CN114917361A ADC-83 payload |
Undisclosed |
CN114917361A ADC-83 linker |
[173] | |
CN109641910A ADC-1 |
CN109641910A ADC-1 payload |
Undisclosed |
CN109641910A ADC-1 linker |
[174] | |
CN109641910A ADC-2 |
CN109641910A ADC-2 payload |
Undisclosed |
CN109641910A ADC-2 linker |
[174] | |
CN109641910A ADC-3 |
CN109641910A ADC-3 payload |
Undisclosed |
CN109641910A ADC-3 linker |
[174] | |
CN109641910A ADC-4 |
CN109641910A ADC-4 payload |
Undisclosed |
CN109641910A ADC-4 linker |
[174] | |
CN109641910A ADC-5 |
CN109641910A ADC-5 payload |
Undisclosed |
CN109641910A ADC-5 linker |
[174] | |
CN109641910A ADC-6 |
CN109641910A ADC-6 payload |
Undisclosed |
CN109641910A ADC-6 linker |
[174] | |
CN109641910A ADC-7 |
CN109641910A ADC-7 payload |
Undisclosed |
CN109641910A ADC-7 linker |
[174] | |
CN109641910A ADC-8 |
CN109641910A ADC-8 payload |
Undisclosed |
CN109641910A ADC-8 linker |
[174] | |
CN109641910A ADC-9 |
CN109641910A ADC-9 payload |
Undisclosed |
CN109641910A ADC-9 linker |
[174] | |
CN109641910A ADC-10 |
CN109641910A ADC-10 payload |
Undisclosed |
CN109641910A ADC-10 linker |
[174] | |
CN109641910A ADC-11 |
CN109641910A ADC-11 payload |
Undisclosed |
CN109641910A ADC-11 linker |
[174] | |
CN109641910A ADC-12 |
CN109641910A ADC-12 payload |
Undisclosed |
CN109641910A ADC-12 linker |
[174] | |
CN109641910A ADC-13 |
CN109641910A ADC-13 payload |
Undisclosed |
CN109641910A ADC-13 linker |
[174] | |
CN109641910A ADC-14 |
CN109641910A ADC-14 payload |
Undisclosed |
CN109641910A ADC-14 linker |
[174] | |
CN109641910A ADC-15 |
CN109641910A ADC-15 payload |
Undisclosed |
CN109641910A ADC-15 linker |
[174] | |
CN109641910A ADC-16 |
CN109641910A ADC-16 payload |
Undisclosed |
CN109641910A ADC-16 linker |
[174] | |
CN105051032B ADC-I-5 |
CN105051032B_ADC-I-5 payload |
Undisclosed |
CN105051032B_ADC-I-5 linker |
[175] | |
CN105051032B ADC-I-6 |
CN105051032B_ADC-I-6 payload |
Undisclosed |
CN105051032B_ADC-I-6 linker |
[175] | |
CN105051032B ADC-I-7 |
CN105051032B_ADC-I-7 payload |
Undisclosed |
CN105051032B_ADC-I-7 linker |
[175] | |
CN105051032B ADC-I-8 |
CN105051032B_ADC-I-8 payload |
Undisclosed |
CN105051032B_ADC-I-8 linker |
[175] | |
CN105051032B ADC-I-9 |
CN105051032B_ADC-I-9 payload |
Undisclosed |
CN105051032B_ADC-I-9 linker |
[175] | |
CN105051032B ADC-I-10 |
CN105051032B_ADC-I-10 payload |
Undisclosed |
CN105051032B_ADC-I-10 linker |
[175] | |
CN105051032B ADC-I-11 |
CN105051032B_ADC-I-11 payload |
Undisclosed |
CN105051032B_ADC-I-11 linker |
[175] | |
CN105051032B ADC-I-12 |
CN105051032B_ADC-I-12 payload |
Undisclosed |
CN105051032B_ADC-I-12 linker |
[175] | |
CN105051032B ADC-I-13 |
CN105051032B_ADC-I-13 payload |
Undisclosed |
CN105051032B_ADC-I-13 linker |
[175] | |
CN105051032B ADC-I-14 |
CN105051032B_ADC-I-14 payload |
Undisclosed |
CN105051032B_ADC-I-14 linker |
[175] | |
CN105051032B ADC-I-15 |
CN105051032B_ADC-I-15 payload |
Undisclosed |
CN105051032B_ADC-I-15 linker |
[175] | |
CN105051032B ADC-I-16 |
CN105051032B_ADC-I-16 payload |
Undisclosed |
CN105051032B_ADC-I-16 linker |
[175] | |
CN105051032B ADC-I-17 |
CN105051032B_ADC-I-17 payload |
Undisclosed |
CN105051032B_ADC-I-17 linker |
[175] | |
CN105051032B ADC-I-18 |
CN105051032B_ADC-I-18 payload |
Undisclosed |
CN105051032B_ADC-I-18 linker |
[175] | |
CN105051032B ADC-I-19 |
CN105051032B_ADC-I-19 payload |
Undisclosed |
CN105051032B_ADC-I-19 linker |
[175] | |
CN105051032B ADC-I-20 |
CN105051032B_ADC-I-20 payload |
Undisclosed |
CN105051032B_ADC-I-20 linker |
[175] | |
CN105051032B ADC-I-21 |
CN105051032B_ADC-I-21 payload |
Undisclosed |
CN105051032B_ADC-I-21 linker |
[175] | |
CN105051032B ADC-I-22 |
CN105051032B_ADC-I-22 payload |
Undisclosed |
CN105051032B_ADC-I-22 linker |
[175] | |
CN105051032B ADC-I-23 |
CN105051032B_ADC-I-23 payload |
Undisclosed |
CN105051032B_ADC-I-23 linker |
[175] | |
CN105051032B ADC-I-24 |
CN105051032B_ADC-I-24 payload |
Undisclosed |
CN105051032B_ADC-I-24 linker |
[175] | |
CN105051032B ADC-I-25 |
CN105051032B_ADC-I-25 payload |
Undisclosed |
CN105051032B_ADC-I-25 linker |
[175] | |
CN105051032B ADC-I-26 |
CN105051032B_ADC-I-26 payload |
Undisclosed |
CN105051032B_ADC-I-26 linker |
[175] | |
CN105051032B ADC-I-27 |
CN105051032B_ADC-I-27 payload |
Undisclosed |
CN105051032B_ADC-I-27 linker |
[175] | |
CN105051032B ADC-I-28 |
CN105051032B_ADC-I-28 payload |
Undisclosed |
CN105051032B_ADC-I-28 linker |
[175] | |
CN105051032B ADC-I-29 |
CN105051032B_ADC-I-29 payload |
Undisclosed |
CN105051032B_ADC-I-29 linker |
[175] | |
CN105051032B ADC-I-30 |
CN105051032B_ADC-I-30 payload |
Undisclosed |
CN105051032B_ADC-I-30 linker |
[175] | |
CN105051032B ADC-I-31 |
CN105051032B_ADC-I-31 payload |
Undisclosed |
CN105051032B_ADC-I-31 linker |
[175] | |
CN105051032B ADC-I-32 |
CN105051032B_ADC-I-32 payload |
Undisclosed |
CN105051032B_ADC-I-32 linker |
[175] | |
CN105051032B ADC-I-33 |
CN105051032B_ADC-I-33 payload |
Undisclosed |
CN105051032B_ADC-I-33 linker |
[175] | |
CN105051032B ADC-I-34 |
CN105051032B_ADC-I-34 payload |
Undisclosed |
CN105051032B_ADC-I-34 linker |
[175] | |
CN105051032B ADC-I-35 |
CN105051032B_ADC-I-35 payload |
Undisclosed |
CN105051032B_ADC-I-35 linker |
[175] | |
CN105051032B ADC-I-36 |
CN105051032B_ADC-I-36 payload |
Undisclosed |
CN105051032B_ADC-I-36 linker |
[175] | |
CN105051032B ADC-I-37 |
CN105051032B_ADC-I-37 payload |
Undisclosed |
CN105051032B_ADC-I-37 linker |
[175] | |
CN105051032B ADC-I-38 |
CN105051032B_ADC-I-38 payload |
Undisclosed |
CN105051032B_ADC-I-38 linker |
[175] | |
CN105051032B ADC-I-39 |
CN105051032B_ADC-I-39 payload |
Undisclosed |
CN105051032B_ADC-I-39 linker |
[175] | |
CN105051032B ADC-I-40 |
CN105051032B_ADC-I-40 payload |
Undisclosed |
CN105051032B_ADC-I-40 linker |
[175] | |
CN105051032B ADC-I-41 |
CN105051032B_ADC-I-41 payload |
Undisclosed |
CN105051032B_ADC-I-41 linker |
[175] | |
WO2014068443A1 ADC1 |
WO2014068443A1_ADC1 payload |
Undisclosed |
WO2014068443A1_ADC1 linker |
[176] | |
WO2014068443A1 ADC2 |
WO2014068443A1_ADC2 payload |
Undisclosed |
WO2014068443A1_ADC2 linker |
[176] | |
WO2014068443A1 ADC3 |
WO2014068443A1_ADC3 payload |
Undisclosed |
WO2014068443A1_ADC3 linker |
[176] | |
WO2014068443A1 ADC4 |
WO2014068443A1_ADC4 payload |
Undisclosed |
WO2014068443A1_ADC4 linker |
[176] | |
WO2014068443A1 ADC5 |
WO2014068443A1_ADC5 payload |
Undisclosed |
WO2014068443A1_ADC5 linker |
[176] | |
WO2014068443A1 ADC6 |
WO2014068443A1_ADC6 payload |
Undisclosed |
WO2014068443A1_ADC6 linker |
[176] | |
WO2014068443A1 ADC7 |
WO2014068443A1_ADC7 payload |
Undisclosed |
WO2014068443A1_ADC7 linker |
[176] | |
WO2014068443A1 ADC8 |
WO2014068443A1_ADC8 payload |
Undisclosed |
WO2014068443A1_ADC8 linker |
[176] | |
WO2014068443A1 ADC9 |
WO2014068443A1_ADC9 payload |
Undisclosed |
WO2014068443A1_ADC9 linker |
[176] | |
WO2014068443A1 ADC10 |
WO2014068443A1_ADC10 payload |
Undisclosed |
WO2014068443A1_ADC10 linker |
[176] | |
WO2014068443A1 ADC11 |
WO2014068443A1_ADC11 payload |
Undisclosed |
WO2014068443A1_ADC11 linker |
[176] | |
WO2014068443A1 ADC12 |
WO2014068443A1_ADC12 payload |
Undisclosed |
WO2014068443A1_ADC12 linker |
[176] | |
WO2014068443A1 ADC13 |
WO2014068443A1_ADC13 payload |
Undisclosed |
WO2014068443A1_ADC13 linker |
[176] | |
WO2014068443A1 ADC14 |
WO2014068443A1_ADC14 payload |
Undisclosed |
WO2014068443A1_ADC14 linker |
[176] | |
WO2014068443A1 ADC15 |
WO2014068443A1_ADC15 payload |
Undisclosed |
WO2014068443A1_ADC15 linker |
[176] | |
WO2014068443A1 ADC16 |
WO2014068443A1_ADC16 payload |
Undisclosed |
WO2014068443A1_ADC16 linker |
[176] | |
WO2014068443A1 ADC17 |
WO2014068443A1_ADC17 payload |
Undisclosed |
WO2014068443A1_ADC17 linker |
[176] | |
WO2014068443A1 ADC18 |
WO2014068443A1_ADC18 payload |
Undisclosed |
WO2014068443A1_ADC18 linker |
[176] | |
WO2014068443A1 ADC19 |
WO2014068443A1_ADC19 payload |
Undisclosed |
WO2014068443A1_ADC19 linker |
[176] | |
WO2014068443A1 ADC20 |
WO2014068443A1_ADC20 payload |
Undisclosed |
WO2014068443A1_ADC20 linker |
[176] | |
WO2014068443A1 ADC21 |
WO2014068443A1_ADC21 payload |
Undisclosed |
WO2014068443A1_ADC21 linker |
[176] | |
WO2014068443A1 ADC22 |
WO2014068443A1_ADC22 payload |
Undisclosed |
WO2014068443A1_ADC22 linker |
[176] | |
WO2014068443A1 ADC23 |
WO2014068443A1_ADC23 payload |
Undisclosed |
WO2014068443A1_ADC23 linker |
[176] | |
WO2014068443A1 ADC24 |
WO2014068443A1_ADC24 payload |
Undisclosed |
WO2014068443A1_ADC24 linker |
[176] | |
WO2014068443A1 ADC25 |
WO2014068443A1_ADC25 payload |
Undisclosed |
WO2014068443A1_ADC25 linker |
[176] | |
WO2014068443A1 ADC26 |
WO2014068443A1_ADC26 payload |
Undisclosed |
WO2014068443A1_ADC26 linker |
[176] | |
WO2014068443A1 ADC27 |
WO2014068443A1_ADC27 payload |
Undisclosed |
WO2014068443A1_ADC27 linker |
[176] | |
WO2014068443A1 ADC28 |
WO2014068443A1_ADC28 payload |
Undisclosed |
WO2014068443A1_ADC28 linker |
[176] | |
WO2014068443A1 ADC29 |
WO2014068443A1_ADC29 payload |
Undisclosed |
WO2014068443A1_ADC29 linker |
[176] | |
WO2014068443A1 ADC30 |
WO2014068443A1_ADC30 payload |
Undisclosed |
WO2014068443A1_ADC30 linker |
[176] | |
WO2014068443A1 ADC31 |
WO2014068443A1_ADC31 payload |
Undisclosed |
WO2014068443A1_ADC31 linker |
[176] | |
WO2014068443A1 ADC32 |
WO2014068443A1_ADC32 payload |
Undisclosed |
WO2014068443A1_ADC32 linker |
[176] | |
WO2014068443A1 ADC33 |
WO2014068443A1_ADC33 payload |
Undisclosed |
WO2014068443A1_ADC33 linker |
[176] | |
WO2014068443A1 ADC34 |
WO2014068443A1_ADC34 payload |
Undisclosed |
WO2014068443A1_ADC34 linker |
[176] | |
WO2014068443A1 ADC35 |
WO2014068443A1_ADC35 payload |
Undisclosed |
WO2014068443A1_ADC35 linker |
[176] | |
WO2014068443A1 ADC36 |
WO2014068443A1_ADC36 payload |
Undisclosed |
WO2014068443A1_ADC36 linker |
[176] | |
WO2014068443A1 ADC37 |
WO2014068443A1_ADC37 payload |
Undisclosed |
WO2014068443A1_ADC37 linker |
[176] | |
WO2014068443A1 ADC38 |
WO2014068443A1_ADC38 payload |
Undisclosed |
WO2014068443A1_ADC38 linker |
[176] | |
WO2014068443A1 ADC39 |
WO2014068443A1_ADC39 payload |
Undisclosed |
WO2014068443A1_ADC39 linker |
[176] | |
WO2014068443A1 ADC40 |
WO2014068443A1_ADC40 payload |
Undisclosed |
WO2014068443A1_ADC40 linker |
[176] | |
WO2014068443A1 ADC41 |
WO2014068443A1_ADC41 payload |
Undisclosed |
WO2014068443A1_ADC41 linker |
[176] | |
WO2014068443A1 ADC42 |
WO2014068443A1_ADC42 payload |
Undisclosed |
WO2014068443A1_ADC42 linker |
[176] | |
WO2014068443A1 ADC43 |
WO2014068443A1_ADC43 payload |
Undisclosed |
WO2014068443A1_ADC43 linker |
[176] | |
WO2014068443A1 ADC44 |
WO2014068443A1_ADC44 payload |
Undisclosed |
WO2014068443A1_ADC44 linker |
[176] | |
WO2014068443A1 ADC45 |
WO2014068443A1_ADC45 payload |
Undisclosed |
WO2014068443A1_ADC45 linker |
[176] | |
WO2014068443A1 ADC46 |
WO2014068443A1_ADC46 payload |
Undisclosed |
WO2014068443A1_ADC46 linker |
[176] | |
WO2014068443A1 ADC47 |
WO2014068443A1_ADC47 payload |
Undisclosed |
WO2014068443A1_ADC47 linker |
[176] | |
WO2014068443A1 ADC48 |
WO2014068443A1_ADC48 payload |
Undisclosed |
WO2014068443A1_ADC48 linker |
[176] | |
WO2014068443A1 ADC49 |
WO2014068443A1_ADC49 payload |
Undisclosed |
WO2014068443A1_ADC49 linker |
[176] | |
WO2014068443A1 ADC50 |
WO2014068443A1_ADC50 payload |
Undisclosed |
WO2014068443A1_ADC50 linker |
[176] | |
WO2014068443A1 ADC51 |
WO2014068443A1_ADC51 payload |
Undisclosed |
WO2014068443A1_ADC51 linker |
[176] | |
WO2014068443A1 ADC52 |
WO2014068443A1_ADC52 payload |
Undisclosed |
WO2014068443A1_ADC52 linker |
[176] | |
WO2014068443A1 ADC53 |
WO2014068443A1_ADC53 payload |
Undisclosed |
WO2014068443A1_ADC53 linker |
[176] | |
WO2014068443A1 ADC54 |
WO2014068443A1_ADC54 payload |
Undisclosed |
WO2014068443A1_ADC54 linker |
[176] | |
WO2014068443A1 ADC55 |
WO2014068443A1_ADC55 payload |
Undisclosed |
WO2014068443A1_ADC55 linker |
[176] | |
WO2014068443A1 ADC56 |
WO2014068443A1_ADC56 payload |
Undisclosed |
WO2014068443A1_ADC56 linker |
[176] | |
WO2014068443A1 ADC57 |
WO2014068443A1_ADC57 payload |
Undisclosed |
WO2014068443A1_ADC57 linker |
[176] | |
WO2014068443A1 ADC58 |
WO2014068443A1_ADC58 payload |
Undisclosed |
WO2014068443A1_ADC58 linker |
[176] | |
WO2014068443A1 ADC59 |
WO2014068443A1_ADC59 payload |
Undisclosed |
WO2014068443A1_ADC59 linker |
[176] | |
WO2014068443A1 ADC60 |
WO2014068443A1_ADC60 payload |
Undisclosed |
WO2014068443A1_ADC60 linker |
[176] | |
WO2014068443A1 ADC61 |
WO2014068443A1_ADC61 payload |
Undisclosed |
WO2014068443A1_ADC61 linker |
[176] | |
WO2014068443A1 ADC62 |
WO2014068443A1_ADC62 payload |
Undisclosed |
WO2014068443A1_ADC62 linker |
[176] | |
WO2014068443A1 ADC63 |
WO2014068443A1_ADC63 payload |
Undisclosed |
WO2014068443A1_ADC63 linker |
[176] | |
WO2014068443A1 ADC64 |
WO2014068443A1_ADC64 payload |
Undisclosed |
WO2014068443A1_ADC64 linker |
[176] | |
WO2014068443A1 ADC65 |
WO2014068443A1_ADC65 payload |
Undisclosed |
WO2014068443A1_ADC65 linker |
[176] | |
WO2014068443A1 ADC66 |
WO2014068443A1_ADC66 payload |
Undisclosed |
WO2014068443A1_ADC66 linker |
[176] | |
WO2014068443A1 ADC67 |
WO2014068443A1_ADC67 payload |
Undisclosed |
WO2014068443A1_ADC67 linker |
[176] | |
WO2014068443A1 ADC68 |
WO2014068443A1_ADC68 payload |
Undisclosed |
WO2014068443A1_ADC68 linker |
[176] | |
WO2014068443A1 ADC69 |
WO2014068443A1_ADC69 payload |
Undisclosed |
WO2014068443A1_ADC69 linker |
[176] | |
WO2014068443A1 ADC70 |
WO2014068443A1_ADC70 payload |
Undisclosed |
WO2014068443A1_ADC70 linker |
[176] | |
WO2014068443A1 ADC71 |
WO2014068443A1_ADC71 payload |
Undisclosed |
WO2014068443A1_ADC71 linker |
[176] | |
WO2014068443A1 ADC72 |
WO2014068443A1_ADC72 payload |
Undisclosed |
WO2014068443A1_ADC72 linker |
[176] | |
WO2014068443A1 ADC73 |
WO2014068443A1_ADC73 payload |
Undisclosed |
WO2014068443A1_ADC73 linker |
[176] | |
WO2014068443A1 ADC74 |
WO2014068443A1_ADC74 payload |
Undisclosed |
WO2014068443A1_ADC74 linker |
[176] | |
WO2014068443A1 ADC75 |
WO2014068443A1_ADC75 payload |
Undisclosed |
WO2014068443A1_ADC75 linker |
[176] | |
WO2014068443A1 ADC76 |
WO2014068443A1_ADC76 payload |
Undisclosed |
WO2014068443A1_ADC76 linker |
[176] | |
WO2014068443A1 ADC77 |
WO2014068443A1_ADC77 payload |
Undisclosed |
WO2014068443A1_ADC77 linker |
[176] | |
WO2014068443A1 ADC78 |
WO2014068443A1_ADC78 payload |
Undisclosed |
WO2014068443A1_ADC78 linker |
[176] | |
WO2014068443A1 ADC79 |
WO2014068443A1_ADC79 payload |
Undisclosed |
WO2014068443A1_ADC79 linker |
[176] | |
WO2014068443A1 ADC80 |
WO2014068443A1_ADC80 payload |
Undisclosed |
WO2014068443A1_ADC80 linker |
[176] | |
WO2014068443A1 ADC81 |
WO2014068443A1_ADC81 payload |
Undisclosed |
WO2014068443A1_ADC81 linker |
[176] | |
WO2014068443A1 ADC82 |
WO2014068443A1_ADC82 payload |
Undisclosed |
WO2014068443A1_ADC82 linker |
[176] | |
WO2014068443A1 ADC83 |
WO2014068443A1_ADC83 payload |
Undisclosed |
WO2014068443A1_ADC83 linker |
[176] | |
WO2014068443A1 ADC84 |
WO2014068443A1_ADC84 payload |
Undisclosed |
WO2014068443A1_ADC84 linker |
[176] | |
Trastuzumab-dTSPEG-MMAF |
Monomethyl auristatin F |
Microtubule (MT) |
dTSPEG |
[177] | |
H2-921 |
Undisclosed |
Undisclosed |
D5 linker |
[178] | |
H2-921 |
SB743921 |
Kinesin spindle protein (KSP) |
CN118987256A, H2-921, Linker |
[179] | |
T-PBA |
PBD-based payload 37b3 |
Undisclosed |
MC-Val-Ala-OH linker |
[180] | |
US20250018051A1 IaⅦ |
US20250018038A1+IaⅥ+payload |
Undisclosed |
Mc-Val-Ala-PABC |
[181] | |
US20250018051A1 IaⅦ |
US20250018038A1+IaⅦ+payload |
Undisclosed |
Mc-Val-Cit-PABC |
[181] | |
T-Ed9 |
Ed9 |
DNA topoisomerase I (TOP1) |
Mc-Gly-Gly-Phe-Gly |
[182] | |
T-VEd9 |
Ed9 |
DNA topoisomerase I (TOP1) |
Mc-Val-Ala |
[182] | |
Tras-DXd-MTL1 |
DX-8951 derivative (DXd); MTT5 |
Undisclosed |
Gly-Mal-Gly-Gly-Phe-Gly |
[183] | |
Trastuzumab-MMAU (DAR4) |
Glucuronyl-monomethyl-auristatin E (MMAU) |
Microtubule (MT) |
Val-Ser (beta-Glc) cleavable linker |
[184] | |
Trastuzumab-MMAU (DAR8) |
Glucuronyl-monomethyl-auristatin E (MMAU) |
Microtubule (MT) |
Val-Ser (beta-Glc) cleavable linker |
[184] | |
38850783 ADC 1 |
Mertansine DM1 |
Microtubule (MT) |
Dimaleimide linker 1 |
[185] | |
38850783 ADC 2 |
Mertansine DM1 |
Microtubule (MT) |
Dimaleimide linker 2 |
[185] | |
38850783 ADC 3 |
Mertansine DM1 |
Microtubule (MT) |
Dimaleimide linker 3 |
[185] | |
38850783 ADC 4 |
Mertansine DM1 |
Microtubule (MT) |
Dimaleimide linker 4 |
[185] | |
38850783 ADC 5 |
Mertansine DM1 |
Microtubule (MT) |
Dimaleimide linker 5 |
[185] | |
39235949 anti-HER2-1 |
Undisclosed |
Undisclosed |
Undisclosed |
[186] | |
39235949 anti-HER2-2 |
Undisclosed |
Undisclosed |
Undisclosed |
[186] | |
39235949 anti-HER2-3 |
Undisclosed |
Undisclosed |
Undisclosed |
[186] | |
39235949 anti-HER2-4 |
Undisclosed |
Undisclosed |
Undisclosed |
[186] | |
39235949 anti-HER2-5 |
Undisclosed |
Undisclosed |
Undisclosed |
[186] | |
39410752 ADC (1) |
Pyrene |
Undisclosed |
Mal-Exo-EVC |
[187] | |
39410752 ADC (2) |
Pyrene |
Undisclosed |
Mal-Exo-EEVC |
[187] | |
39410752 ADC (3) |
Pyrene |
Undisclosed |
Mc-Val-Cit-PABC |
[187] | |
39410752 ADC (4) |
Pyrene |
Undisclosed |
Mc-EVC-PAB |
[187] | |
39410752 ADC (5) |
Monomethyl auristatin E |
Microtubule (MT) |
Mal-Exo-EVC |
[187] | |
39410752 ADC (6) |
Monomethyl auristatin E |
Microtubule (MT) |
Mal-Exo-EEVC |
[187] | |
39410752 ADC (7) |
Exatecan |
DNA topoisomerase 1 (TOP1) |
Mal-Exo-EEVC |
[187] | |
39410752 ADC (8) |
Monomethyl auristatin E |
Microtubule (MT) |
Mal-Exo-EEVC |
[187] | |
39410752 ADC (9) |
Exatecan |
DNA topoisomerase 1 (TOP1) |
Mal-Exo-EEVC |
[187] | |
39410752 ADC (10) |
Monomethyl auristatin E |
Microtubule (MT) |
Mc-Val-Cit-PABC |
[187] | |
39410752 ADC (11) |
Monomethyl auristatin E |
Microtubule (MT) |
Mc-Val-Cit-PABC |
[187] | |
39410752 ADC (12) |
Monomethyl auristatin E |
Microtubule (MT) |
Mc-EVC-PAB |
[187] | |
37492000 ADC 6a (4h) |
Monomethyl auristatin E |
Microtubule (MT) |
TetraDVP based linker 1a |
[188] | |
37492000 ADC 6b (4h) |
Monomethyl auristatin E |
Microtubule (MT) |
TetraDVP based linker 1b |
[188] | |
37492000 ADC 6c (4h) |
Monomethyl auristatin E |
Microtubule (MT) |
TetraDVP based linker 1c |
[188] | |
37492000 ADC 6d (4h) |
Monomethyl auristatin E |
Microtubule (MT) |
TetraDVP based linker 1d |
[188] | |
37492000 ADC 7a (4h) |
Monomethyl auristatin E |
Microtubule (MT) |
TetraDVP based linker 2a |
[188] | |
37492000 ADC 7b (4h) |
Monomethyl auristatin E |
Microtubule (MT) |
TetraDVP based linker 2b |
[188] | |
37492000 ADC 7c (4h) |
Monomethyl auristatin E |
Microtubule (MT) |
TetraDVP based linker 2c |
[188] | |
37492000 ADC 7d (4h) |
Monomethyl auristatin E |
Microtubule (MT) |
TetraDVP based linker 2d |
[188] | |
37492000 ADC 6a (24h) |
Monomethyl auristatin E |
Microtubule (MT) |
TetraDVP based linker 1a |
[188] | |
37492000 ADC 6b (24h) |
Monomethyl auristatin E |
Microtubule (MT) |
TetraDVP based linker 1b |
[188] | |
37492000 ADC 6c (24h) |
Monomethyl auristatin E |
Microtubule (MT) |
TetraDVP based linker 1c |
[188] | |
37492000 ADC 6d (24h) |
Monomethyl auristatin E |
Microtubule (MT) |
TetraDVP based linker 1d |
[188] | |
37492000 ADC 7a (24h) |
Monomethyl auristatin E |
Microtubule (MT) |
TetraDVP based linker 2a |
[188] | |
37492000 ADC 7b (24h) |
Monomethyl auristatin E |
Microtubule (MT) |
TetraDVP based linker 2b |
[188] | |
37492000 ADC 7c (24h) |
Monomethyl auristatin E |
Microtubule (MT) |
TetraDVP based linker 2c |
[188] | |
37492000 ADC 7d (24h) |
Monomethyl auristatin E |
Microtubule (MT) |
TetraDVP based linker 2d |
[188] | |
Tras-Exa |
Exatecan |
DNA topoisomerase 1 (TOP1) |
AB2 self-immolative dendritic scaffold |
[189] | |
Tras-Bel |
Belotecan |
DNA topoisomerase 1 (TOP1) |
AB2 self-immolative dendritic scaffold |
[189] | |
DEVD ADC |
Exatecan |
DNA topoisomerase 1 (TOP1) |
MC-DEVD-PAB |
[190] | |
36924655 ADC 28 |
Monomethyl auristatin E |
Microtubule (MT) |
Undisclosed |
[191] | |
36924655 ADC 29 |
Monomethyl auristatin E |
Microtubule (MT) |
Undisclosed |
[191] | |
36924655 ADC 30 |
Monomethyl auristatin E |
Microtubule (MT) |
Undisclosed |
[191] | |
36924655 ADC 31 |
Monomethyl auristatin E |
Microtubule (MT) |
Undisclosed |
[191] | |
36924655 ADC 5 |
Monomethyl auristatin E |
Microtubule (MT) |
Undisclosed |
[191] | |
36924655 ADC 6 |
Monomethyl auristatin E |
Microtubule (MT) |
Undisclosed |
[191] | |
36924655 ADC 7 |
Monomethyl auristatin E |
Microtubule (MT) |
Undisclosed |
[191] | |
36924655 ADC 8 |
Monomethyl auristatin E |
Microtubule (MT) |
Undisclosed |
[191] | |
36924655 ADC 9 |
Monomethyl auristatin E |
Microtubule (MT) |
Undisclosed |
[191] | |
36924655 ADC 10 |
Monomethyl auristatin E |
Microtubule (MT) |
Undisclosed |
[191] | |
36924655 ADC 11 |
Monomethyl auristatin E |
Microtubule (MT) |
Undisclosed |
[191] | |
36924655 ADC 12 |
Monomethyl auristatin E |
Microtubule (MT) |
Undisclosed |
[191] | |
36924655 ADC 13 |
Monomethyl auristatin E |
Microtubule (MT) |
Undisclosed |
[191] | |
36924655 ADC 14 |
Monomethyl auristatin E |
Microtubule (MT) |
Undisclosed |
[191] | |
36924655 ADC 15 |
Monomethyl auristatin E |
Microtubule (MT) |
Undisclosed |
[191] | |
Trastuzumab-DXd (38003245) |
DX-8951 derivative (DXd) |
DNA topoisomerase 1 (TOP1) |
Undisclosed |
[192] | |
37307297 ADC 1 |
FD-1 |
Undisclosed |
Mc-Val-Cit-PABC |
[193] | |
37307297 ADC 2 |
FD-1 |
Undisclosed |
Undisclosed |
[193] | |
37307297 ADC 3 |
FD-1 |
Undisclosed |
Undisclosed |
[193] | |
37307297 ADC 4 |
FD-1 |
Undisclosed |
Undisclosed |
[193] | |
37307297 ADC 5 |
FD-1 |
Undisclosed |
Undisclosed |
[193] | |
37307297 ADC 6 |
FD-1 |
Undisclosed |
Undisclosed |
[193] | |
37307297 ADC 7 |
FD-1 |
Undisclosed |
Undisclosed |
[193] | |
37307297 ADC 8 |
FD-1 |
Undisclosed |
Undisclosed |
[193] | |
37307297 ADC 9 |
FD-1 |
Undisclosed |
Undisclosed |
[193] | |
37307297 ADC 12 |
FD-2 |
Undisclosed |
Undisclosed |
[193] | |
37307297 ADC 13 |
FD-2 |
Undisclosed |
Undisclosed |
[193] | |
37307297 ADC 14 |
FD-3 |
Undisclosed |
Undisclosed |
[193] | |
Trastuzumab-LplA-MMAE |
Monomethyl auristatin E |
Microtubule (MT) |
DBCO-Val-Cit-PABC |
[194] | |
Tras-16a |
14a 39321689 |
Undisclosed |
Mc-Gly-Gly-Phe-Gly |
[195] | |
Tras-16b |
14b 39321689 |
Undisclosed |
Mc-Gly-Gly-Phe-Gly |
[195] | |
37486969 ADC 36 |
STING Agonist 6 |
Undisclosed |
Undisclosed |
[196] | |
37486969 ADC 37 |
STING Agonist 6 |
Undisclosed |
Undisclosed |
[196] | |
37486969 ADC 38 |
STING Agonist 6 |
Undisclosed |
Undisclosed |
[196] | |
37486969 ADC 39 |
STING Agonist 4 |
Undisclosed |
Undisclosed |
[196] | |
37486969 ADC 40 |
STING Agonist 4 |
Undisclosed |
Undisclosed |
[196] | |
37486969 ADC 42 |
STING Agonist 15 |
Undisclosed |
Undisclosed |
[196] | |
37486969 ADC 43 |
STING Agonist 15 |
Undisclosed |
Undisclosed |
[196] | |
37486969 ADC 44 |
STING Agonist 15 |
Undisclosed |
Undisclosed |
[196] | |
37486969 ADC 45 |
STING Agonist 15 |
Undisclosed |
Undisclosed |
[196] | |
37486969 ADC 46 |
STING Agonist 15 |
Undisclosed |
Undisclosed |
[196] | |
T-VCR 6a |
Vincristine (VCR) |
Undisclosed |
Mc-Val-Cit-PABC |
[197] | |
T-VCR 6b |
Vincristine (VCR) |
Undisclosed |
Mc-Val-Cit-PABC |
[197] | |
37217025 ADC-1 |
TLR7/8 agonist 1 |
Undisclosed |
MT-VC-PABC |
[198] | |
37217025 ADC-2 |
TLR7/8 agonist 20h |
Undisclosed |
MT-VC-PABC |
[198] | |
37917829 ADC 2 |
RIPK2 PROTAC |
Undisclosed |
Undisclosed |
[199] | |
37828728 ADC 1 |
Exatecan |
DNA topoisomerase 1 (TOP1) |
P5 (OEt)-VC-PAB |
[200] | |
37828728 ADC 2 |
Exatecan |
DNA topoisomerase 1 (TOP1) |
P5 (PEG2)-VC-PAB |
[200] | |
37828728 ADC 3 |
Exatecan |
DNA topoisomerase 1 (TOP1) |
P5 (PEG12)-VC-PAB |
[200] | |
37828728 ADC 4 |
Exatecan |
DNA topoisomerase 1 (TOP1) |
P5 (PEG12)-VA-PAB |
[200] | |
37828728 ADC 5 |
Exatecan |
DNA topoisomerase 1 (TOP1) |
P5 (PEG24)-VC-PAB |
[200] | |
37828728 ADC 6 |
Exatecan |
DNA topoisomerase 1 (TOP1) |
Mc-Val-Cit-PABC |
[200] | |
37828728 ADC 7 |
Exatecan |
DNA topoisomerase 1 (TOP1) |
P5 (PEG12)-VA |
[200] | |
37828728 ADC 8 |
Exatecan |
DNA topoisomerase 1 (TOP1) |
P5- (PEG12) |
[200] | |
HER2-14 |
CPTS-1 |
Undisclosed |
Mal-Val-Ala-PAB |
[201] | |
HER2-16 |
CPTS-1 |
Undisclosed |
Mc-Val-Cit-PABC |
[201] | |
HER2-17 |
WL-14 |
Undisclosed |
Mal-Val-Ala-PAB |
[201] | |
HER2-18 |
WL-14 |
Undisclosed |
Mc-Val-Cit-PABC |
[201] | |
Trastuzumab- (VC-PABC-MMAE)2 |
Monomethyl auristatin E |
Microtubule (MT) |
Undisclosed |
[202] | |
Trastuzumab-DM1 (K248) |
Mertansine DM1 |
Microtubule (MT) |
Undisclosed |
[203] | |
Trastuzumab-MMAE (K248) |
Monomethyl auristatin E |
Microtubule (MT) |
Undisclosed |
[203] | |
Trastuzumab-MMAE (K288) |
Monomethyl auristatin E |
Microtubule (MT) |
Undisclosed |
[203] | |
38888299 ADC 1 |
Monomethyl auristatin E |
Microtubule (MT) |
Tuneable thiol exchange linker 1 |
[204] | |
38888299 ADC 2 |
Monomethyl auristatin E |
Microtubule (MT) |
Tuneable thiol exchange linker 2 |
[204] | |
38888299 ADC 3 |
Monomethyl auristatin E |
Microtubule (MT) |
Tuneable thiol exchange linker 3 |
[204] | |
Trastu-AzaNIRII-MMAE |
Monomethyl auristatin E |
Microtubule (MT) |
azaNIRII-BCN-PEG4-VAC-PAB |
[205] | |
Tra-CL2A-FL118 (11) |
Undisclosed |
Undisclosed |
CL2A |
[206] | |
39337633 2ICy7-Ab |
Diiodinated heptamethine cyanine |
Undisclosed |
Undisclosed |
[207] | |
Cy7-Ab |
Heptamethine cyanine |
Undisclosed |
Undisclosed |
[207] | |
[111In]In-ADCS |
Undisclosed |
Undisclosed |
Undisclosed |
[208] | |
[111In]In-AD |
Undisclosed |
Undisclosed |
Undisclosed |
[208] | |
HER2-25 |
Tolllike receptor 7/8 agonist 18 |
Undisclosed |
Undisclosed |
[209] | |
HER2-26 |
Tolllike receptor 7/8 agonist 18 |
Undisclosed |
Undisclosed |
[209] | |
37222285 ADC 1 |
Auri E |
Undisclosed |
sulfatase-responsive linker |
[210] | |
Tras-DSPEK248 |
Undisclosed |
Undisclosed |
Undisclosed |
[211] | |
Tmab-VcMMAE-SMCC-DM1 |
Monomethyl auristatin E; Maytansinoid DM1 |
Undisclosed |
Mc-Val-Cit-PABC; Succinimidyl-4- (N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC) |
[212] | |
TZ-dSA3-2 |
diABZI STING agonist 3 |
Undisclosed |
Undisclosed |
[213] | |
TZ-dSA3-4 |
diABZI STING agonist 3 |
Undisclosed |
Undisclosed |
[213] | |
TZ-dSA3-8 |
diABZI STING agonist 3 |
Undisclosed |
Undisclosed |
[213] | |
TZ-dSA3-12 |
diABZI STING agonist 3 |
Undisclosed |
Undisclosed |
[213] | |
Anti-HER2_VCGP-Dex |
Dexamethasone |
Glucocorticoid receptor (NR3C1) |
Mal-ValCitGlyPro-OH |
[214] | |
Tras-2C |
Undisclosed |
Undisclosed |
Undisclosed |
[84] | |
Tras-5C |
Undisclosed |
Undisclosed |
Undisclosed |
[84] | |
HC-A118C-1a |
Monomethyl auristatin E |
Microtubule (MT) |
Undisclosed |
[215] | |
HC-A118C-1b |
Monomethyl auristatin E |
Microtubule (MT) |
Undisclosed |
[215] | |
HC-A118C-2 |
Monomethyl auristatin E |
Microtubule (MT) |
Undisclosed |
[215] | |
HC-A118C-3 |
Monomethyl auristatin E |
Microtubule (MT) |
Undisclosed |
[215] | |
HC-A118C-4 |
Monomethyl auristatin E |
Microtubule (MT) |
Undisclosed |
[215] | |
HC-A140C-1a |
Monomethyl auristatin E |
Microtubule (MT) |
Undisclosed |
[215] | |
HC-A140C-1b |
Monomethyl auristatin E |
Microtubule (MT) |
Undisclosed |
[215] | |
HC-A140C-2 |
Monomethyl auristatin E |
Microtubule (MT) |
Undisclosed |
[215] | |
HC-A140C-3 |
Monomethyl auristatin E |
Microtubule (MT) |
Undisclosed |
[215] | |
HC-A140C-4 |
Monomethyl auristatin E |
Microtubule (MT) |
Undisclosed |
[215] | |
HC-E258C-1a |
Monomethyl auristatin E |
Microtubule (MT) |
Undisclosed |
[215] | |
HC-E258C-1b |
Monomethyl auristatin E |
Microtubule (MT) |
Undisclosed |
[215] | |
HC-E258C-2 |
Monomethyl auristatin E |
Microtubule (MT) |
Undisclosed |
[215] | |
HC-E258C-3 |
Monomethyl auristatin E |
Microtubule (MT) |
Undisclosed |
[215] | |
HC-E258C-4 |
Monomethyl auristatin E |
Microtubule (MT) |
Undisclosed |
[215] | |
HC-S400C-1a |
Monomethyl auristatin E |
Microtubule (MT) |
Undisclosed |
[215] | |
HC-S400C-1b |
Monomethyl auristatin E |
Microtubule (MT) |
Undisclosed |
[215] | |
HC-S400C-2 |
Monomethyl auristatin E |
Microtubule (MT) |
Undisclosed |
[215] | |
HC-S400C-3 |
Monomethyl auristatin E |
Microtubule (MT) |
Undisclosed |
[215] | |
HC-S400C-4 |
Monomethyl auristatin E |
Microtubule (MT) |
Undisclosed |
[215] | |
LC-K149C-1a |
Monomethyl auristatin E |
Microtubule (MT) |
Undisclosed |
[215] | |
LC-K149C-1b |
Monomethyl auristatin E |
Microtubule (MT) |
Undisclosed |
[215] | |
LC-K149C-2 |
Monomethyl auristatin E |
Microtubule (MT) |
Undisclosed |
[215] | |
LC-K149C-3 |
Monomethyl auristatin E |
Microtubule (MT) |
Undisclosed |
[215] | |
LC-K149C-4 |
Monomethyl auristatin E |
Microtubule (MT) |
Undisclosed |
[215] | |
LC-V205C-1a |
Monomethyl auristatin E |
Microtubule (MT) |
Undisclosed |
[215] | |
LC-V205C-1b |
Monomethyl auristatin E |
Microtubule (MT) |
Undisclosed |
[215] | |
LC-V205C-2 |
Monomethyl auristatin E |
Microtubule (MT) |
Undisclosed |
[215] | |
LC-V205C-3 |
Monomethyl auristatin E |
Microtubule (MT) |
Undisclosed |
[215] | |
LC-V205C-4 |
Monomethyl auristatin E |
Microtubule (MT) |
Undisclosed |
[215] | |
WT ADC |
Monomethyl auristatin E |
Microtubule (MT) |
Mc-Val-Cit-PABC |
[216] | |
Trastuzumab-TCO-Pot-Tz |
Porphyrin (Por)-tetrazine (Tz) |
Undisclosed |
Undisclosed |
[217] | |
Trastuzumab 20 |
PBD-butanamide derivative |
Undisclosed |
Mc-Val-Ala |
[218] | |
Antibody-fluorophore conjugate FCY (11) |
Biorthogonal azide 9 |
Undisclosed |
Undisclosed |
[219] | |
CN119343374A ADC-S109 |
Undisclosed |
Undisclosed |
Undisclosed |
[90] | |
CN119343374A ADC-S110 |
Undisclosed |
Undisclosed |
Undisclosed |
[90] | |
CN119343374A ADC-S111 |
Undisclosed |
Undisclosed |
Undisclosed |
[90] | |
CN119343374A ADC-S423 |
Undisclosed |
Undisclosed |
Undisclosed |
[90] | |
CN119343374A ADC-S426 |
Undisclosed |
Undisclosed |
Undisclosed |
[90] | |
CN119343374A ADC-TRA41C |
Undisclosed |
Undisclosed |
Undisclosed |
[90] | |
Trastuzumab-Example 1 |
CN119343152A 1C1-Example1 Payload |
Microtubule (MT) |
CN119343152A 1C1-Example1 Linker |
[220] | |
Trastuzumab-Example 2 |
CN119343152A 1C1-Example1 Payload |
Microtubule (MT) |
CN119343152A 1C1-Example2 Linker |
[220] | |
Trastuzumab-Example 3 |
CN119343152A 1C1-Example3 Payload1; CN119343152A 1C1-Example3 Payload2 |
Undisclosed |
CN119343152A 1C1-Example3 Linker |
[220] | |
Trastuzumab-Example 4 |
CN119343152A 1C1-Example1 Payload; CN119343152A 1C1-Example4 Payload |
Undisclosed |
CN119343152A 1C1-Example4 Linker |
[220] | |
Trastuzumab-Example 5 |
CN119343152A Trastuzumab-Example5 Payload |
Microtubule (MT) |
CN119343152A 1C1-Example1 Linker |
[220] | |
Trastuzumab-Example 6 |
CN119343152A Trastuzumab-Example6 Payload |
DNA topoisomerase I (TOP1) |
CN119343152A 1C1-Example1 Linker |
[220] | |
Trastuzumab-Example 7 |
CN119343152A Trastuzumab-Example6 Payload |
DNA topoisomerase I (TOP1) |
CN119343152A Trastuzumab-Example7 Linker |
[220] | |
Trastuzumab-Example 8 |
DX-8951 derivative (DXd) |
DNA topoisomerase 1 (TOP1) |
CN119343152A Trastuzumab-Example8 Linker |
[220] | |
Trastuzumab-GDP-D-P2/P4-P4-GGFG-Dxd |
DX-8951 derivative (DXd) |
DNA topoisomerase 1 (TOP1) |
CN119343152A Trastuzumab-GDP-D-P2/P4-P4-GGFG-Dxd Linker |
[221] | |
Trastuzumab-GDP-K-P2/P4-P4-GGFG-Dxd |
DX-8951 derivative (DXd) |
DNA topoisomerase 1 (TOP1) |
CN119326907A Trastuzumab-GDP-D-P2/P4-P4-GGFG-Dxd Linker |
[221] | |
Trastuzumab-GDP-D-P2/P8-P4-GGFG-Dxd |
DX-8951 derivative (DXd) |
DNA topoisomerase 1 (TOP1) |
CN119326907A Trastuzumab-GDP-D-P2/P8-P4-GGFG-Dxd Linker |
[221] | |
Trastuzumab-GDP-D-P1/P2-P4-GGFG-Dxd |
DX-8951 derivative (DXd) |
DNA topoisomerase 1 (TOP1) |
CN119326907A Trastuzumab-GDP-D-P2/P4-P4-GGFG-Dxd Linker |
[221] | |
Trastuzumab-GDP-D-P1/P1-P4-GGFG-Dxd |
DX-8951 derivative (DXd) |
DNA topoisomerase 1 (TOP1) |
CN119326907A Trastuzumab-GDP-D-P1/P1-P4-GGFG-Dxd Linker |
[221] | |
Trastuzumab-GDP-D-P2/P4-P1-GGFG-Dxd |
DX-8951 derivative (DXd) |
DNA topoisomerase 1 (TOP1) |
CN119326907A Trastuzumab-GDP-D-P2/P4-P1-GGFG-Dxd Linker |
[221] | |
Trastuzumab-GDP-D-P2/P4-P2-GGFG-Dxd |
DX-8951 derivative (DXd) |
DNA topoisomerase 1 (TOP1) |
CN119326907A Trastuzumab-GDP-D-P2/P4-P2-GGFG-Dxd Linker |
[221] | |
Trastuzumab-GDP-D-P1/P1-P1-GGFG-Dxd |
DX-8951 derivative (DXd) |
DNA topoisomerase 1 (TOP1) |
CN119326907A Trastuzumab-GDP-D-P1/P1-P1-GGFG-Dxd Linker |
[221] | |
Trastuzumab-GDP-D-P1/P1-P2-GGFG-Dxd |
DX-8951 derivative (DXd) |
DNA topoisomerase 1 (TOP1) |
CN119326907A Trastuzumab-GDP-D-P1/P1-P2-GGFG-Dxd Linker |
[221] | |
Trastuzumab-GDP-D-P1/P1-C2-GGFG-Dxd |
DX-8951 derivative (DXd) |
DNA topoisomerase 1 (TOP1) |
CN119326907A Trastuzumab-GDP-D-P1/P1-C2-GGFG-Dxd Linker |
[221] | |
Trastuzumab-GDP-D-P1/P2-C2-GGFG-Dxd |
DX-8951 derivative (DXd) |
DNA topoisomerase 1 (TOP1) |
CN119326907A Trastuzumab-GDP-D-P1/P2-C2-GGFG-Dxd Linker |
[221] | |
Trastuzumab-GDP-D-P1/P2-P1-GGFG-Dxd |
DX-8951 derivative (DXd) |
DNA topoisomerase 1 (TOP1) |
CN119326907A Trastuzumab-GDP-D-P1/P2-P1-GGFG-Dxd Linker |
[221] | |
Trastuzumab-GDP-N-P1/P2-P1-GGFG-Dxd |
DX-8951 derivative (DXd) |
DNA topoisomerase 1 (TOP1) |
CN119326907A Trastuzumab-GDP-N-P1/P2-P1-GGFG-Dxd Linker |
[221] | |
Trastuzumab-GDP-N-P1/P1-P1-GGFG-Dxd |
DX-8951 derivative (DXd) |
DNA topoisomerase 1 (TOP1) |
CN119326907A Trastuzumab-GDP-N-P1/P1-P1-GGFG-Dxd Linker |
[221] | |
Trastuzumab-GDP-D-P2/P2-P2-GGFG-Dxd |
DX-8951 derivative (DXd) |
DNA topoisomerase 1 (TOP1) |
Trastuzumab-GDP-D-P2/P2-P2-GGFG-Dxd Linker |
[221] | |
AB185-ADL10-D8 |
D8 payload |
Undisclosed |
6-Maleimidocaproic acid |
[222] | |
AB185-ADL10-D1 |
D1 payload |
Undisclosed |
6-Maleimidocaproic acid |
[222] | |
AB185-ADL5-D17 |
D17 payload |
Undisclosed |
Mc-Val-Cit-PAB (Qamine) linker |
[222] | |
AB185-ADL1-D16 |
D16 payload |
Undisclosed |
Mc-Val-Cit-PABC |
[222] | |
AB185-ADL5-D26 |
D26 payload |
Undisclosed |
Mc-Val-Cit-PAB (Qamine) linker |
[222] | |
AB185-ADL1-D14 |
D14 payload |
Undisclosed |
Mc-Val-Cit-PABC |
[222] | |
AB185-ADL5-D15 |
D15 payload |
Undisclosed |
Mc-Val-Cit-PAB (Qamine) linker |
[222] | |
AB185-ADL5-D11 |
D11 payload |
Undisclosed |
Mc-Val-Cit-PAB (Qamine) linker |
[222] | |
AB185-ADL1-D33 |
D33 payload |
Undisclosed |
Mc-Val-Cit-PABC |
[222] | |
AB185-ADL1-D22 |
D22 payload |
Undisclosed |
Mc-Val-Cit-PABC |
[222] | |
AB185-ADL12-D2 |
D2 payload |
Undisclosed |
Mal- (CH2)6- linker |
[222] | |
AB185-ADL1-D13 |
D13 payload |
Undisclosed |
Mc-Val-Cit-PABC |
[222] | |
AB185-ADL5-D19 |
D19 payload |
Undisclosed |
Mc-Val-Cit-PAB (Qamine) linker |
[222] | |
AB185-ADL5-D10 |
D10 payload |
Undisclosed |
Mc-Val-Cit-PAB (Qamine) linker |
[222] | |
AB185-ADL6-D9 |
D9 payload |
Undisclosed |
Mc-Val-Cit-PABC |
[222] | |
AB185-ADL5-D2 4.14 |
D2 payload |
Undisclosed |
Mc-Val-Cit-PAB (Qamine) linker |
[222] | |
AB185-ADL1-D8 |
D8 payload |
Undisclosed |
Mc-Val-Cit-PABC |
[222] | |
AB185-ADL15-D2 |
D2 payload |
Undisclosed |
Mal-CH2CH2-O-CH2CH2- linker |
[222] | |
AB185-ADL12-D20 |
D20 payload |
Undisclosed |
Mal- (CH2)6- linker |
[222] | |
AB185-ADL12-D1 3.3 |
D1 payload |
Undisclosed |
Mal- (CH2)6- linker |
[222] | |
AB185-ADL5-D2 8.5 |
D2 payload |
Undisclosed |
Mc-Val-Cit-PAB (Qamine) linker |
[222] | |
AB185-ADL6-D1 |
D1 payload |
Undisclosed |
Mc-Val-Cit-PABC |
[222] | |
AB185-ADL12-D1 3 |
D1 payload |
Undisclosed |
Mal- (CH2)6- linker |
[222] | |
AB185-ADL12-D22 |
D22 payload |
Undisclosed |
Mal- (CH2)6- linker |
[222] | |
AB185-ADL1-D4 8 |
D4 payload |
Undisclosed |
Mc-Val-Cit-PABC |
[222] | |
AB185-ADL15-D1 |
D1 payload |
Undisclosed |
Mal-CH2CH2-O-CH2CH2- linker |
[222] | |
AB185-ADL14-D1 |
D14 payload |
Undisclosed |
Mal-CH2CH2- linker |
[222] | |
AB185-ADL1-D4 2.8 |
undisclosed |
Undisclosed |
Mc-Val-Cit-PABC |
[222] | |
AB185-ADL1-D1 |
D1 payload |
Undisclosed |
Mc-Val-Cit-PABC |
[222] | |
AB185-ADL5-D25 |
D25 payload |
Undisclosed |
Mc-Val-Cit-PABC |
[222] | |
AB185-ADL12-D21 |
D21 payload |
Undisclosed |
Mal- (CH2)6- linker |
[222] | |
AB185-ADL1-D18 |
D18 payload |
Undisclosed |
Mc-Val-Cit-PABC |
[222] | |
AB185-ADL1-D12 |
D12 payload |
Undisclosed |
Mc-Val-Cit-PABC |
[222] | |
AB185-ADL13-D4 |
D4 payload |
Undisclosed |
B-glucuronide linker |
[222] | |
AB185-ADL1-D5 |
D5 payload |
Undisclosed |
Mc-Val-Cit-PABC |
[222] | |
AB185-ADL1-D3 |
D3 Payload payload |
Undisclosed |
Undisclosed |
[222] | |
CN118924912A anti-HER2 ADC1 |
CN118924912A anti-HER2 ADC1 Payload |
Undisclosed |
CN118924912A anti-HER2 ADC1 Linker |
[223] | |
CN118924912A anti-HER2 ADC2 |
CN118924912A anti-HER2 ADC2 Payload |
Undisclosed |
CN118924912A anti-HER2 ADC1 Linker |
[223] | |
CN118924912A anti-HER2 ADC3 |
CN118924912A anti-HER2 ADC3 Payload |
Undisclosed |
CN118924912A anti-HER2 ADC1 Linker |
[223] | |
CN118924912A anti-HER2 ADC4 |
CN118924912A anti-HER2 ADC4 Payload |
Undisclosed |
CN118924912A anti-HER2 ADC1 Linker |
[223] | |
CN118924912A anti-HER2 ADC5 |
CN118924912A anti-HER2 ADC5 Payload |
Undisclosed |
CN118924912A anti-HER2 ADC1 Linker |
[223] | |
CN118924912A anti-HER2 ADC6 |
CN118924912A anti-HER2 ADC6 Payload |
Undisclosed |
CN118924912A anti-HER2 ADC1 Linker |
[223] | |
CN118924912A anti-HER2 ADC7 |
CN118924912A anti-HER2 ADC7 Payload |
Undisclosed |
CN118924912A anti-HER2 ADC1 Linker |
[223] | |
CN118924912A anti-HER2 ADC8 |
CN118924912A anti-HER2 ADC8 Payload |
Undisclosed |
CN118924912A anti-HER2 ADC1 Linker |
[223] | |
CN118924912A anti-HER2 ADC9 |
CN118924912A anti-HER2 ADC9 Payload |
Undisclosed |
CN118924912A anti-HER2 ADC1 Linker |
[223] | |
CN118924912A anti-HER2 ADC10 |
CN118924912A anti-HER2 ADC10 Payload |
Undisclosed |
CN118924912A anti-HER2 ADC1 Linker |
[223] | |
CN118924912A anti-HER2 ADC11 |
CN118924912A anti-HER2 ADC11 Payload |
Undisclosed |
CN118924912A anti-HER2 ADC1 Linker |
[223] | |
CN118924912A anti-HER2 ADC12 |
CN118924912A anti-HER2 ADC12 Payload |
Undisclosed |
CN118924912A anti-HER2 ADC1 Linker |
[223] | |
CN118924912A anti-HER2 ADC13 |
CN118924912A anti-HER2 ADC13 Payload |
Undisclosed |
CN118924912A anti-HER2 ADC1 Linker |
[223] | |
CN118924912A anti-HER2 ADC14 |
CN118924912A anti-HER2 ADC14 Payload |
Undisclosed |
CN118924912A anti-HER2 ADC1 Linker |
[223] | |
CN118924912A anti-HER2 ADC15 |
CN118924912A anti-HER2 ADC15 Payload |
Undisclosed |
CN118924912A anti-HER2 ADC1 Linker |
[223] | |
CN118924912A anti-HER2 ADC16 |
CN118924912A anti-HER2 ADC16 Payload |
Undisclosed |
CN118924912A anti-HER2 ADC1 Linker |
[223] | |
CN118924912A anti-HER2 ADC17 |
CN118924912A anti-HER2 ADC17 Payload |
Undisclosed |
CN118924912A anti-HER2 ADC1 Linker |
[223] | |
CN118924912A anti-HER2 ADC18 |
CN118924912A anti-HER2 ADC18 Payload |
Undisclosed |
CN118924912A anti-HER2 ADC1 Linker |
[223] | |
CN118924912A anti-HER2 ADC19 |
CN118924912A anti-HER2 ADC19 Payload |
Undisclosed |
CN118924912A anti-HER2 ADC1 Linker |
[223] | |
CN118924912A anti-HER2 ADC20 |
CN118924912A anti-HER2 ADC20 Payload |
Undisclosed |
CN118924912A anti-HER2 ADC1 Linker |
[223] | |
CN118401256A ADC 1 |
Monomethyl auristatin E |
Microtubule (MT) |
Allenamide-Amcap-Val-Cit-PABC |
[224] | |
CN118401256A ADC 2 |
Monomethyl auristatin E |
Microtubule (MT) |
Maleimido-caproyl-Val-Cit-PABC |
[224] | |
CN117750982A ADC58 |
CN117750982A ADC58 Payload |
Undisclosed |
CN117750982A ADC58 Linker |
[225] | |
CN117750982A ADC59 |
CN117750982A ADC58 Payload |
Undisclosed |
CN117750982A ADC59 Linker |
[225] | |
CN117750982A ADC60 |
CN117750982A ADC58 Payload |
Undisclosed |
CN117750982A ADC60 Linker |
[225] | |
CN117750982A ADC61 |
CN117750982A ADC58 Payload |
Undisclosed |
CN117750982A ADC61 Linker |
[225] | |
CN117750982A ADC62 |
CN117750982A ADC62 Payload |
Undisclosed |
CN117750982A ADC58 Linker |
[225] | |
CN117750982A ADC63 |
CN117750982A ADC62 Payload |
Undisclosed |
CN117750982A ADC59 Linker |
[225] | |
CN117750982A ADC64 |
CN117750982A ADC62 Payload |
Undisclosed |
CN117750982A ADC60 Linker |
[225] | |
CN117750982A ADC65 |
CN117750982A ADC62 Payload |
Undisclosed |
CN117750982A ADC61 Linker |
[225] | |
CN114615999B ADC-1 |
CN114615999B ADC-1 Payload |
Undisclosed |
CN114615999B ADC-1 Linker |
[226] | |
CN114615999B ADC-2 |
CN114615999B ADC-1 Payload |
Undisclosed |
CN114615999B ADC-2 Linker |
[226] | |
CN114615999B ADC-3 |
CN114615999B ADC-3 Payload |
Undisclosed |
CN114615999B ADC-2 Linker |
[226] | |
CN114615999B ADC-4 |
CN114615999B ADC-1 Payload |
Undisclosed |
CN114615999B ADC-1 Linker |
[226] | |
CN114615999B ADC-5 |
CN114615999B ADC-3 Payload |
Undisclosed |
CN114615999B ADC-2 Linker |
[226] | |
US20230109312A1 ADC with 4 MMAF |
Monomethyl auristatin F |
Microtubule (MT) |
US20230109312A1 ADC with 4 MMAF Linker |
[227] | |
US20220226492A1 Immunoconjugate A |
undisclosed |
Undisclosed |
Undisclosed |
[228] | |
US20220226492A1 Immunoconjugate B |
undisclosed |
Undisclosed |
Undisclosed |
[228] | |
US20220226492A1 Immunoconjugate C |
undisclosed |
Undisclosed |
Undisclosed |
[228] | |
US20220226492A1 Immunoconjugate D |
undisclosed |
Undisclosed |
Undisclosed |
[228] | |
US20220226492A1 Immunoconjugate E |
undisclosed |
Undisclosed |
Undisclosed |
[228] | |
US20220226492A1 Immunoconjugate F |
undisclosed |
Undisclosed |
Undisclosed |
[228] | |
US20220226492A1 Immunoconjugate G |
undisclosed |
Undisclosed |
Undisclosed |
[228] | |
US20220226492A1 Immunoconjugate H |
undisclosed |
Undisclosed |
Undisclosed |
[228] | |
US20220226492A1 Immunoconjugate I |
undisclosed |
Undisclosed |
Undisclosed |
[228] | |
US20220226492A1 Immunoconjugate J |
undisclosed |
Undisclosed |
Undisclosed |
[228] | |
US20220226492A1 Immunoconjugate L |
undisclosed |
Undisclosed |
Undisclosed |
[228] | |
US20220226492A1 Immunoconjugate M |
undisclosed |
Undisclosed |
Undisclosed |
[228] | |
US20220226492A1 Immunoconjugate N |
undisclosed |
Undisclosed |
Undisclosed |
[228] | |
US20220226492A1 Immunoconjugate O |
undisclosed |
Undisclosed |
Undisclosed |
[228] | |
US20220226492A1 Immunoconjugate P |
undisclosed |
Undisclosed |
Undisclosed |
[228] | |
US20220226492A1 Immunoconjugate Q |
undisclosed |
Undisclosed |
Undisclosed |
[228] | |
US20220226492A1 Immunoconjugate R |
undisclosed |
Undisclosed |
Undisclosed |
[228] | |
US20220226492A1 Immunoconjugate S |
undisclosed |
Undisclosed |
Undisclosed |
[228] | |
US20220226492A1 Immunoconjugate T |
undisclosed |
Undisclosed |
Undisclosed |
[228] | |
US20220226492A1 Immunoconjugate U |
undisclosed |
Undisclosed |
Undisclosed |
[228] | |
US20220226492A1 Immunoconjugate V |
undisclosed |
Undisclosed |
Undisclosed |
[228] | |
US20220226492A1 Immunoconjugate K1 |
undisclosed |
Undisclosed |
Undisclosed |
[228] | |
US20220226492A1 Immunoconjugate R1 |
undisclosed |
Undisclosed |
Undisclosed |
[228] | |
CN115515644A ADC-1-b |
CN115515644A ADC-1-a Payload |
Undisclosed |
CN115515644A ADC-1-a Linker |
[229] | |
CN115515644A ADC-2-b |
CN115515644A ADC-1-a Payload |
Undisclosed |
CN115515644A ADC-2-a Linker |
[229] | |
CN115515644A ADC-3-b |
CN115515644A ADC-1-a Payload |
Undisclosed |
CN115515644A ADC-3-a Linker |
[229] | |
CN115515644A ADC-4-b |
CN115515644A ADC-1-a Payload |
Undisclosed |
CN115515644A ADC-4-a Linker |
[229] | |
CN115515644A ADC-5-b |
CN115515644A ADC-1-a Payload |
Undisclosed |
CN115515644A ADC-5-a Linker |
[229] | |
JP7623413B2 ExampleADC9 |
Undisclosed |
Undisclosed |
Undisclosed |
[230] | |
JP7623413B2 ExampleADC45 |
Undisclosed |
Undisclosed |
Undisclosed |
[230] | |
US12144865B2 1e |
Undisclosed |
Undisclosed |
Undisclosed |
[231] | |
US12144865B2 2e |
Undisclosed |
Undisclosed |
Undisclosed |
[231] | |
US12144865B2 5e |
Undisclosed |
Undisclosed |
Undisclosed |
[231] | |
US12144865B2 6e |
Undisclosed |
Undisclosed |
Undisclosed |
[231] | |
US12144865B2 8e |
Undisclosed |
Undisclosed |
Undisclosed |
[231] | |
US12144865B2 11e |
Undisclosed |
Undisclosed |
Undisclosed |
[231] | |
US12144865B2 12e |
Undisclosed |
Undisclosed |
Undisclosed |
[231] | |
US12144865B2 13e |
Undisclosed |
Undisclosed |
Undisclosed |
[231] | |
US12144865B2 14e |
Undisclosed |
Undisclosed |
Undisclosed |
[231] | |
US12144865B2 16e |
Undisclosed |
Undisclosed |
Undisclosed |
[231] | |
US12144865B2 17e |
Undisclosed |
Undisclosed |
Undisclosed |
[231] | |
US12144865B2 18e |
Undisclosed |
Undisclosed |
Undisclosed |
[231] | |
US12144865B2 19e |
Undisclosed |
Undisclosed |
Undisclosed |
[231] | |
US12144865B2 21e |
Undisclosed |
Undisclosed |
Undisclosed |
[231] | |
US12144865B2 22e |
Undisclosed |
Undisclosed |
Undisclosed |
[231] | |
US12144865B2 23e |
Undisclosed |
Undisclosed |
Undisclosed |
[231] | |
US12144865B2 24e |
Undisclosed |
Undisclosed |
Undisclosed |
[231] | |
US12144865B2 25e |
Undisclosed |
Undisclosed |
Undisclosed |
[231] | |
US12144865B2 26e |
Undisclosed |
Undisclosed |
Undisclosed |
[231] | |
US12144865B2 27e |
Undisclosed |
Undisclosed |
Undisclosed |
[231] | |
US12144865B2 28e |
Undisclosed |
Undisclosed |
Undisclosed |
[231] | |
US12144865B2 29e |
Undisclosed |
Undisclosed |
Undisclosed |
[231] | |
US12144865B2 30e |
Undisclosed |
Undisclosed |
Undisclosed |
[231] | |
US12144865B2 35e |
Undisclosed |
Undisclosed |
Undisclosed |
[231] | |
US12144865B2 36e |
Undisclosed |
Undisclosed |
Undisclosed |
[231] | |
US12144865B2 37e |
Undisclosed |
Undisclosed |
Undisclosed |
[231] | |
US12144865B2 38e |
Undisclosed |
Undisclosed |
Undisclosed |
[231] | |
US12144865B2 39e |
Undisclosed |
Undisclosed |
Undisclosed |
[231] | |
US12144865B2 40e |
Undisclosed |
Undisclosed |
Undisclosed |
[231] | |
US12144865B2 41e |
Undisclosed |
Undisclosed |
Undisclosed |
[231] | |
US12144865B2 42e |
Undisclosed |
Undisclosed |
Undisclosed |
[231] | |
US12144865B2 43e |
Undisclosed |
Undisclosed |
Undisclosed |
[231] | |
US12144865B2 44e |
Undisclosed |
Undisclosed |
Undisclosed |
[231] | |
Trastuzumab-LD1 |
seco-DUBA |
Human Deoxyribonucleic acid (hDNA) |
Trastuzumab-LD1-LINKER |
[235] | |
Trastuzumab-LD3 |
seco-DUBA |
Human Deoxyribonucleic acid (hDNA) |
Trastuzumab-LD3-LINKER |
[235] | |
Trastuzumab-LD4 |
seco-DUBA |
Human Deoxyribonucleic acid (hDNA) |
Trastuzumab-LD1-LINKER |
[235] | |
Trastuzumab-LD5 |
seco-DUBA |
Human Deoxyribonucleic acid (hDNA) |
Trastuzumab-LD1-LINKER |
[235] | |
Trastuzumab-LD6 |
seco-DUBA |
Human Deoxyribonucleic acid (hDNA) |
Trastuzumab-LD1-LINKER |
[235] | |
Trastuzumab-LD7 |
Undisclosed |
Undisclosed |
Trastuzumab-LD7-LINKER |
[235] | |
Trastuzumab-LD8 |
Undisclosed |
Undisclosed |
Trastuzumab-LD8-LINKER |
[235] | |
AU2017363246B2 Conjugate28 |
AU2017363246B2+Conjugate28+Payload |
Undisclosed |
Undisclosed |
[236] | |
AU2017363246B2 Conjugate31A |
AU2017363246B2+Conjugate31+Payload |
Undisclosed |
AU2017363246B2+Conjugate31+Linker |
[236] | |
AU2017363246B2 Conjugate31B |
AU2017363246B2+Conjugate31+Payload |
Undisclosed |
AU2017363246B2+Conjugate31+Linker |
[236] | |
AU2017363246B2 Conjugate34A |
AU2017363246B2+Conjugate34+Payload |
Undisclosed |
AU2017363246B2+Conjugate34+Linker |
[236] | |
AU2017363246B2 Conjugate34B |
AU2017363246B2+Conjugate34+Payload |
Undisclosed |
AU2017363246B2+Conjugate34+Linker |
[236] | |
AU2017363246B2 Conjugate43A |
AU2017363246B2+Conjugate43+Payload |
Undisclosed |
AU2017363246B2+Conjugate43+Linker |
[236] | |
AU2017363246B2 Conjugate43B |
AU2017363246B2+Conjugate43+Payload |
Undisclosed |
AU2017363246B2+Conjugate43+Linker |
[236] | |
AU2017363246B2 Conjugate46A |
AU2017363246B2+Conjugate46+Payload |
Undisclosed |
AU2017363246B2+Conjugate46+Linker |
[236] | |
AU2017363246B2 Conjugate46B |
AU2017363246B2+Conjugate46+Payload |
Undisclosed |
AU2017363246B2+Conjugate46+Linker |
[236] | |
AU2017363246B2 Conjugate48 |
AU2017363246B2+Conjugate48+Payload |
Undisclosed |
AU2017363246B2+Conjugate48+Linker |
[236] | |
AU2017363246B2 Conjugate52 |
AU2017363246B2+Conjugate52+Payload |
Undisclosed |
AU2017363246B2+Conjugate52+Linker |
[236] | |
AU2017363246B2 Conjugate67 |
AU2017363246B2+Conjugate67+Payload |
Undisclosed |
AU2017363246B2+Conjugate67+Linker |
[236] | |
AU2017363246B2 Conjugate68 |
AU2017363246B2+Conjugate68+Payload |
Undisclosed |
AU2017363246B2+Conjugate68+Linker |
[236] | |
AU2017363246B2 Conjugate25 |
AU2017363246B2+Conjugate25+Payload |
Undisclosed |
AU2017363246B2+Conjugate25+Linker |
[236] | |
AU2023226367A1-1 |
RU20241285-1-payload |
Undisclosed |
RU20241285-1-linker |
[237] | |
AU2023226367A1-2 |
U-030 |
DNA topoisomerase I (TOP1) |
RU20241285-1-linker |
[237] | |
AU2023226367A1-3 |
Auristatin E |
Microtubule (MT) |
RU20241285-3-linker |
[237] | |
AU2023226367A1-4 |
RU20241285-4-payload |
Undisclosed |
RU20241285-4-linker |
[237] | |
AU2023226367A1-5 |
RU20241285-5-payload |
Undisclosed |
RU20241285-1-linker |
[237] | |
AU2023226367A1-6 |
RU20241285-6-payload |
Undisclosed |
RU20241285-6-linker |
[237] | |
AU2023226367A1-7 |
Monomethyl auristatin E |
Microtubule (MT) |
RU20241285-7-linker |
[237] | |
AU2023226367A1-8 |
Monomethyl auristatin E |
Microtubule (MT) |
RU20241285-8-linker |
[237] | |
AU2023226367A1-9 |
RU20241285-9-payload |
Undisclosed |
RU20241285-9-linker |
[237] | |
AU2023226367A1-10 |
RU20241285-10-payload |
Undisclosed |
RU20241285-10-linker |
[237] | |
AU2023226367A1-11 |
DX-8951 derivative (DXd) |
DNA topoisomerase 1 (TOP1) |
RU20241285-10-linker |
[237] | |
AU2023226367A1-12 |
DX-8951 derivative (DXd) |
DNA topoisomerase 1 (TOP1) |
RU20241285-12-linker |
[237] | |
AU2023226367A1-13 |
DX-8951 derivative (DXd) |
DNA topoisomerase 1 (TOP1) |
RU20241285-13-linker |
[237] | |
AU2023226367A1-14 |
Eribulin |
Microtubule (MT) |
RU20241285-8-linker |
[237] | |
AU2023226367A1-15 |
RU20241285-15-payload |
Undisclosed |
RU20241285-15-linker |
[237] | |
AU2023226367A1-16 |
Eribulin |
Microtubule (MT) |
EP4487874A1-18linker |
[237] | |
AU2023226367A1-17 |
Eribulin |
Microtubule (MT) |
RU20241285-17-linker |
[237] | |
AU2023226367A1-18 |
Eribulin |
Microtubule (MT) |
RU20241285-18-linker |
[237] | |
AU2023226367A1-19 |
Auristatin E |
Microtubule (MT) |
RU20241285-19-linker |
[237] | |
AU2023226367A1-20 |
Topo1 inhibitor A |
DNA topoisomerase I (TOP1) |
EP4487874A1-13linker |
[237] | |
AU2023226367A1-21 |
RU20241285-21-payload |
Undisclosed |
RU20241285-21-linker |
[237] | |
AU2023226367A1-22 |
RU20241285-22-payload |
Undisclosed |
RU20241285-22-linker |
[237] | |
AU2023226367A1-23 |
RU20241285-23-payload |
DNA topoisomerase I (TOP1) |
RU20241285-23-linker |
[237] | |
AU2023226367A1-24 |
RU20241285-23-payload |
DNA topoisomerase I (TOP1) |
RU20241285-24-linker |
[237] | |
ZA202500114A-ADC-6 |
Undisclosed |
Undisclosed |
Undisclosed |
[238] | |
ZA202500415A-ADC Example 1 |
NMT inhibitor 1 |
N-Myristoyltransferase (NMT) |
ZA202500415A-ADC-Example-1-Linker |
[239] | |
ZA202500415A-ADC Example 5 |
NMT inhibitor 26 |
N-Myristoyltransferase (NMT) |
ZA202500415A-ADC-Example-1-Linker |
[239] | |
ZA202500415A-ADC Example 6 |
ZA202500415A-ADC-Example-6-payload |
N-Myristoyltransferase (NMT) |
ZA202500415A-ADC-Example-1-Linker |
[239] | |
ZA202500415A-ADC Example 7 |
NMT inhibitor 1 |
N-Myristoyltransferase (NMT) |
Mc-Gly-Gly-Phe-Gly |
[239] | |
HER2-ADC-001 |
DL001-payload; DL003-payload |
Undisclosed |
DL001-Linker; DL003-Linker |
[240] | |
HER2-ADC-002 |
DL007-payload; DL003-payload |
Undisclosed |
DL007-Linker; DL003-Linker |
[240] | |
HER2-ADC-003 |
DL007-payload; DL003-payload |
Undisclosed |
DL007-Linker; DL003-Linker |
[240] | |
HER2-ADC-004 |
DL007-payload; DL002-payload |
Undisclosed |
DL007-Linker; DL002-Linker |
[240] | |
HER2-ADC-005 |
DL012-payload; DL003-payload |
Undisclosed |
DL012-Linker; DL003-Linker |
[240] | |
HER2-ADC-006 |
DL012-payload; DL003-payload |
Undisclosed |
DL012-Linker; DL003-Linker |
[240] | |
HER2-ADC-007 |
DL012-payload; DL003-payload |
Undisclosed |
DL012-Linker; DL003-Linker |
[240] | |
HER2-ADC-008 |
DL012-payload; DL003-payload |
Undisclosed |
DL012-Linker; DL003-Linker |
[240] | |
HER2-ADC-009 |
DL012-payload; DL003-payload |
Undisclosed |
DL012-Linker; DL003-Linker |
[240] | |
HER2-ADC-010 |
DL014-payload; DL003-payload |
Undisclosed |
DL014-Linker; DL003-Linker |
[240] | |
HER2-ADC-011 |
DL014-payload; DL003-payload |
Undisclosed |
DL014-Linker; DL003-Linker |
[240] | |
HER2-ADC-012 |
DL014-payload; DL003-payload |
Undisclosed |
DL014-Linker; DL003-Linker |
[240] | |
HER2-ADC-013 |
DL012-payload; DL003-payload |
Undisclosed |
DL012-Linker; DL003-Linker |
[240] | |
HER2-ADC-014 |
DL017-payload; DL003-payload |
Undisclosed |
DL017-Linker; DL003-Linker |
[240] | |
HER2-ADC-015 |
DL017-payload; DL003-payload |
Undisclosed |
DL017-Linker; DL003-Linker |
[240] | |
HER2-DL012-DAR2 |
DL012-payload |
Undisclosed |
DL012-Linker |
[240] | |
HER2-DL003-DAR8 |
DL003-payload |
Undisclosed |
DL003-Linker |
[240] | |
Trastuzumab N221 (WT)-MMAF #1 |
Monomethyl auristatin F |
Microtubule (MT) |
Undisclosed |
[241] | |
Trastuzumab N221 (WT)-MMAF #2 |
Monomethyl auristatin F |
Microtubule (MT) |
Undisclosed |
[241] | |
Trastuzumab N221 (GDLN)-MMAF |
Monomethyl auristatin F |
Microtubule (MT) |
Undisclosed |
[241] | |
Tras-LN-MMAF |
Monomethyl auristatin F |
Microtubule (MT) |
Undisclosed |
[241] | |
Tras.D221N-MMAF (HEK GDLN) |
Monomethyl auristatin F |
Microtubule (MT) |
Undisclosed |
[241] | |
Tras.D221N-MMAF (HEK WT) |
Monomethyl auristatin F |
Microtubule (MT) |
Undisclosed |
[241] | |
WO2023047090A1-MMAE ADC |
Monomethyl auristatin E |
Microtubule (MT) |
Undisclosed |
[94] | |
WO2023047090A1-SN-38 reagent (11) ADC |
Undisclosed |
Undisclosed |
Undisclosed |
[94] | |
WO2023047090A1-SN-38 reagent (13) ADC |
Undisclosed |
Undisclosed |
Undisclosed |
[94] | |
AU2020291014A1 IC-1 |
AU2020291014A1-Payload-2 |
Undisclosed |
Aminobenzazepine-linker Formula II-2 |
[242] | |
AU2020291014A1 IC-2 |
AU2020291014A1-Payload-3 |
Undisclosed |
Aminobenzazepine-linker Formula II-3 |
[242] | |
AU2020291014A1 IC-3 |
AU2020291014A1-Payload-2 |
Undisclosed |
Aminobenzazepine-linker Formula II-4 |
[242] | |
AU2020291014A1 IC-4 |
AU2020291014A1-Payload-2 |
Undisclosed |
Aminobenzazepine-linker Formula II-5 |
[242] | |
AU2020291014A1 IC-5 |
Undisclosed |
Undisclosed |
Undisclosed |
[242] | |
AU2020291014A1 IC-6 |
Undisclosed |
Undisclosed |
Undisclosed |
[242] | |
AU2020291014A1 IC-7 |
Undisclosed |
Undisclosed |
Undisclosed |
[242] | |
AU2020291014A1 IC-8 |
AU2020291014A1-Payload-70 |
Undisclosed |
Aminobenzazepine-linker Formula II-15 |
[242] | |
AU2020291014A1 IC-10 |
AU2020291014A1-Payload-16 |
Undisclosed |
Aminobenzazepine-linker Formula II-16 |
[242] | |
AU2020291014A1 IC-11 |
AU2020291014A1-Payload-17 |
Undisclosed |
Aminobenzazepine-linker Formula II-17 |
[242] | |
AU2020291014A1 IC-12 |
AU2020291014A1-Payload-18 |
Undisclosed |
Aminobenzazepine-linker Formula II-17 |
[242] | |
AU2020291014A1 IC-13 |
AU2020291014A1-Payload-19 |
Undisclosed |
Aminobenzazepine-linker Formula II-17 |
[242] | |
AU2020291014A1 IC-14 |
AU2020291014A1-Payload-70 |
Undisclosed |
Aminobenzazepine-linker Formula II-17 |
[242] | |
AU2020291014A1 IC-16 |
Undisclosed |
Undisclosed |
Undisclosed |
[242] | |
AU2020291014A1 IC-17 |
AU2020291014A1-Payload-70 |
Undisclosed |
Aminobenzazepine-linker Formula II-22 |
[242] | |
AU2020291014A1 IC-18 |
AU2020291014A1-Payload-25 |
Undisclosed |
Aminobenzazepine-linker Formula II-25 |
[242] | |
AU2020291014A1 IC-19 |
AU2020291014A1-Payload-27 |
Undisclosed |
Aminobenzazepine-linker Formula II-27 |
[242] | |
AU2020291014A1 IC-20 |
AU2020291014A1-Payload-70 |
Undisclosed |
Aminobenzazepine-linker Formula II-31 |
[242] | |
AU2020291014A1 IC-21 |
Undisclosed |
Undisclosed |
Undisclosed |
[242] | |
AU2020291014A1 IC-22 |
AU2020291014A1-Payload-33 |
Undisclosed |
Aminobenzazepine-linker Formula II-33 |
[242] | |
AU2020291014A1 IC-23 |
AU2020291014A1-Payload-35 |
Undisclosed |
Aminobenzazepine-linker Formula II-33 |
[242] | |
AU2020291014A1 IC-24 |
AU2020291014A1-Payload-36 |
Undisclosed |
Aminobenzazepine-linker Formula II-36 |
[242] | |
AU2020291014A1 IC-25 |
Undisclosed |
Undisclosed |
Undisclosed |
[242] | |
AU2020291014A1 IC-26 |
Undisclosed |
Undisclosed |
Undisclosed |
[242] | |
AU2020291014A1 IC-27 |
AU2020291014A1-Payload-34 |
Undisclosed |
Aminobenzazepine-linker Formula II-34 |
[242] | |
AU2020291014A1 IC-28 |
AU2020291014A1-Payload-39 |
Undisclosed |
Undisclosed |
[242] | |
AU2020291014A1 IC-29 |
AU2020291014A1-Payload-40 |
Undisclosed |
Undisclosed |
[242] | |
AU2020291014A1 IC-30 |
AU2020291014A1-Payload-41 |
Undisclosed |
Undisclosed |
[242] | |
AU2020291014A1 IC-31 |
AU2020291014A1-Payload-42 |
Undisclosed |
Aminobenzazepine-linker Formula II-42 |
[242] | |
AU2020291014A1 IC-32 |
undisclosed |
Undisclosed |
Undisclosed |
[242] | |
AU2020291014A1 IC-33 |
undisclosed |
Undisclosed |
Undisclosed |
[242] | |
AU2020291014A1 IC-34 |
undisclosed |
Undisclosed |
Undisclosed |
[242] | |
AU2020291014A1 IC-35 |
undisclosed |
Undisclosed |
Undisclosed |
[242] | |
AU2020291014A1 IC-38 |
AU2020291014A1-Payload-49 |
Undisclosed |
Undisclosed |
[242] | |
AU2020291014A1 IC-40 |
undisclosed |
Undisclosed |
Undisclosed |
[242] | |
AU2020291014A1 IC-41 |
undisclosed |
Undisclosed |
Undisclosed |
[242] | |
AU2020291014A1 IC-42 |
undisclosed |
Undisclosed |
Undisclosed |
[242] | |
AU2020291014A1 IC-43 |
undisclosed |
Undisclosed |
Undisclosed |
[242] | |
AU2020291014A1 IC-44 |
undisclosed |
Undisclosed |
Undisclosed |
[242] | |
AU2020291014A1 IC-45 |
undisclosed |
Undisclosed |
Undisclosed |
[242] | |
AU2020291014A1 IC-50 |
undisclosed |
Undisclosed |
Undisclosed |
[242] | |
AU2020291014A1 IC-52 |
undisclosed |
Undisclosed |
Undisclosed |
[242] | |
AU2020291014A1 IC-53 |
undisclosed |
Undisclosed |
Undisclosed |
[242] | |
AU2020291014A1 IC-54 |
undisclosed |
Undisclosed |
Undisclosed |
[242] | |
AU2020291014A1 IC-55 |
undisclosed |
Undisclosed |
Undisclosed |
[242] | |
AU2020291014A1 IC-56 |
undisclosed |
Undisclosed |
Undisclosed |
[242] | |
AU2020291014A1 IC-59 |
undisclosed |
Undisclosed |
Undisclosed |
[242] | |
AU2020291014A1 IC-60 |
undisclosed |
Undisclosed |
Undisclosed |
[242] | |
AU2020291014A1 IC-61 |
undisclosed |
Undisclosed |
Undisclosed |
[242] | |
AU2020291014A1 IC-62 |
AU2020291014A1-Payload-69 |
Undisclosed |
Aminobenzazepine-linker Formula II-69 |
[242] | |
AU2020291014A1 IC-65 |
AU2020291014A1-Payload-70 |
Undisclosed |
Aminobenzazepine-linker Formula II-69 |
[242] | |
AU2020291014A1 IC-66 |
AU2020291014A1-Payload-72 |
Undisclosed |
Aminobenzazepine-linker Formula II-72 |
[242] | |
AU2020291014A1 IC-70 |
undisclosed |
Undisclosed |
Undisclosed |
[242] | |
AU2020291014A1 IC-71 |
undisclosed |
Undisclosed |
Undisclosed |
[242] | |
AU2020291014A1 IC-74 |
undisclosed |
Undisclosed |
Undisclosed |
[242] | |
AU2020291014A1 IC-75 |
AU2020291014A1-Payload-74 |
Undisclosed |
Undisclosed |
[242] | |
AU2020291014A1 IC-76 |
AU2020291014A1-Payload-77 |
Undisclosed |
Aminobenzazepine-linker Formula II-72 |
[242] | |
AU2020291014A1 IC-77 |
AU2020291014A1-Payload-35 |
Undisclosed |
Aminobenzazepine-linker Formula II-75 |
[242] | |
AU2020291014A1 IC-78 |
AU2020291014A1-Payload-78 |
Undisclosed |
Aminobenzazepine-linker Formula II-69 |
[242] | |
AU2020291014A1 IC-79 |
AU2020291014A1-Payload-70 |
Undisclosed |
Aminobenzazepine-linker Formula II-75 |
[242] | |
AU2020291014A1 IC-86 |
AU2020291014A1-Payload-80 |
Undisclosed |
Aminobenzazepine-linker Formula II-80 |
[242] | |
AU2020291014A1 IC-87 |
AU2020291014A1-Payload-82 |
Undisclosed |
Aminobenzazepine-linker Formula II-82 |
[242] | |
AU2020291014A1 IC-90 |
undisclosed |
Undisclosed |
Undisclosed |
[242] | |
AU2020291014A1 IC-91 |
AU2020291014A1-Payload-85 |
Undisclosed |
Aminobenzazepine-linker Formula II-75 |
[242] | |
AU2020291014A1 IC-92 |
AU2020291014A1-Payload-69 |
Undisclosed |
Aminobenzazepine-linker Formula II-69 |
[242] | |
Tra-25-4 |
PBX-7014 |
DNA topoisomerase I (TOP1) |
Mc-Gly-Gly-Phe-Gly |
[243] | |
Tra-25-6 |
PBX-7016 |
DNA topoisomerase I (TOP1) |
Mc-Gly-Gly-Phe-Gly |
[243] | |
EP4494656A1 DM-II |
DM-II Payload |
Undisclosed |
DM-II Linker |
[245] | |
EP4494656A1 DM-III |
DM-III Payload |
Undisclosed |
DM-III Linker |
[245] | |
EP4494656A1 DM-IV |
undisclosed |
Undisclosed |
Undisclosed |
[245] | |
EP4494656A1 DM-V |
undisclosed |
Undisclosed |
Undisclosed |
[245] | |
DS-24 |
DS-24 Payload |
Undisclosed |
DS-24 Linker |
[246] | |
DS-26 |
DS-24 Payload |
Undisclosed |
DS-26 Linker |
[246] | |
WO2019126691A1 Conjugate No.5 |
Conjugate No.5 Payload |
Undisclosed |
Conjugate No.5 Linker |
[247] | |
WO2019126691A1 Conjugate No.10 |
Conjugate No.10 Payload |
Undisclosed |
Conjugate No.5 Linker |
[247] | |
WO2019126691A1 Conjugate No.20 |
Conjugate No.20 Payload |
Undisclosed |
Conjugate No.20 Linker |
[247] | |
WO2019126691A1 Conjugate No.26 |
Conjugate No.26 Payload |
Undisclosed |
Conjugate No.26 Linker |
[247] | |
WO2019126691A1 Conjugate No.31 |
Conjugate No.31 Payload |
Undisclosed |
Conjugate No.20 Linker |
[247] | |
WO2019126691A1 Conjugate No.36 |
Conjugate No.26 Payload |
Undisclosed |
Conjugate No.36 Linker |
[247] | |
WO2019126691A1 Conjugate No.38 |
Conjugate No.26 Payload |
Undisclosed |
Conjugate No.38 Linker |
[247] | |
WO2019126691A1 Conjugate No.46 |
Conjugate No.46 Payload |
Undisclosed |
Conjugate No.46 Linker |
[247] | |
WO2019126691A1 Conjugate No.57 |
Conjugate No.57 Payload |
Undisclosed |
Conjugate No.57 Linker |
[247] | |
WO2019126691A1 Conjugate No.60 |
Conjugate No.60 Payload |
Undisclosed |
Conjugate No.5 Linker |
[247] | |
WO2019126691A1 Conjugate No.67 |
Conjugate No.67 Payload |
Undisclosed |
Conjugate No.67 Linker |
[247] | |
WO2019126691A1 Conjugate No.71 |
Conjugate No.57 Payload |
Undisclosed |
Conjugate No.71 Linker |
[247] | |
WO2019126691A1 Conjugate No.73 |
Conjugate No.67 Payload |
Undisclosed |
Conjugate No.73 Linker |
[247] | |
WO2019126691A1 Conjugate No.79 |
Conjugate No.57 Payload |
Undisclosed |
Conjugate No.79 Linker |
[247] | |
WO2019126691A1 Conjugate No.86 |
Conjugate No.67 Payload |
Undisclosed |
DL18 linker |
[247] | |
WO2019126691A1 Conjugate No.94 |
Conjugate No.94 Payload |
Undisclosed |
Conjugate No.94 Linker |
[247] | |
WO2019126691A1 Conjugate No.105 |
Conjugate No.105 Payload |
Undisclosed |
Conjugate No.105 Linker |
[247] | |
WO2019126691A1 Conjugate No.112 |
Conjugate No.112 Payload |
Undisclosed |
Conjugate No.112 Linker |
[247] | |
WO2019126691A1 Conjugate No.115 |
Conjugate No.112 Payload |
Undisclosed |
Conjugate No.115 Linker |
[247] | |
WO2019126691A1 Conjugate No.119 |
Conjugate No.94 Payload |
Undisclosed |
Conjugate No.119 Linker |
[247] | |
WO2019126691A1 Conjugate No.122 |
Conjugate No.94 Payload |
Undisclosed |
Conjugate No.122 Linker |
[247] | |
WO2019126691A1 Conjugate No.130 |
Conjugate No.130 Payload |
Undisclosed |
Conjugate No.105 Linker |
[247] | |
WO2019126691A1 Conjugate No.137 |
Conjugate No.137 Payload |
Undisclosed |
Conjugate No.105 Linker |
[247] | |
CN115429893A ADC1 |
CN115429893A ADC1 Payload |
Undisclosed |
CB07 linker |
[248] | |
CN115429893A ADC2 |
CN115429893A ADC2 Payload |
Undisclosed |
CB07 linker |
[248] | |
CN115429893A ADC3 |
CN115429893A ADC3 Payload |
Undisclosed |
Mc-Gly-Gly-Phe-Gly |
[248] | |
Trastuzumab-C-7 |
Undisclosed |
Undisclosed |
KR1020250002133A Trastuzumab-C-7 Linker |
[249] | |
Trastuzumab-C-8 |
KR1020250002133A Trastuzumab-C-8 Payload |
Undisclosed |
KR1020250002133A Trastuzumab-C-8 Linker |
[249] | |
Trastuzumab-C-9 |
Undisclosed |
Undisclosed |
KR1020250002133A Trastuzumab-C-9 Linker |
[249] | |
Trastuzumab-C-10 |
undisclosed |
Undisclosed |
KR1020250002133A Trastuzumab-C-10 Linker |
[249] | |
Trastuzumab-C-11 |
undisclosed |
Undisclosed |
KR1020250002133A Trastuzumab-C-11 Linker |
[249] | |
Trastuzumab-C-15 |
undisclosed |
Undisclosed |
KR1020250002133A Trastuzumab-C-15 Linker |
[249] | |
Trastuzumab-C-16 |
undisclosed |
Undisclosed |
KR1020250002133A Trastuzumab-C-16 Linker |
[249] | |
Trastuzumab-C-17 |
undisclosed |
Undisclosed |
KR1020250002133A Trastuzumab-C-117 Linker |
[249] | |
Trastuzumab-C-20 |
undisclosed |
Undisclosed |
KR1020250002133A Trastuzumab-C-20 Linker |
[249] | |
Trastuzumab-C-21 |
undisclosed |
Undisclosed |
KR1020250002133A Trastuzumab-C-21 Linker |
[249] | |
Trastuzumab-C-22 |
WO2023221971A1 NEC49-4 Payload |
Undisclosed |
KR1020250002133A Trastuzumab-C-22 Linker |
[249] | |
HK40112172A Antibody-drug conjugate (2) |
HK40112172A+Antibody-drug conjugate (2)+payload |
Undisclosed |
HK40112172A+Antibody-drug conjugate (2)+Linker |
[250] | |
HK40112172A Antibody-drug conjugate (3) |
HK40112172A+Antibody-drug conjugate (3)+payload |
Undisclosed |
Mc-Gly-Gly-Phe-Gly |
[250] | |
HK40112172A Antibody-drug conjugate (4) |
HK40112172A+Antibody-drug conjugate (4)+payload |
Undisclosed |
HK40112172A+Antibody-drug conjugate (4)+Linker |
[250] | |
HK40112172A Antibody-drug conjugate (5) |
LT4212552T ADC10 payload |
DNA topoisomerase I (TOP1) |
HK40112172A+Antibody-drug conjugate (4)+Linker |
[250] | |
HK40112172A Antibody-drug conjugate (6) |
LT4212552T ADC10 payload |
DNA topoisomerase I (TOP1) |
HK40112172A+Antibody-drug conjugate (6)+Linker |
[250] | |
HK40112172A Antibody-drug conjugate (7) |
LT4212552T ADC10 payload |
DNA topoisomerase I (TOP1) |
HK40112172A+Antibody-drug conjugate (7)+Linker |
[250] | |
HK40112172A Antibody-drug conjugate (8) |
LT4212552T ADC10 payload |
DNA topoisomerase I (TOP1) |
HK40112172A+Antibody-drug conjugate (7)+Linker |
[250] | |
HK40112172A Antibody-drug conjugate (9) |
LT4212552T ADC10 payload |
DNA topoisomerase I (TOP1) |
HK40112172A+Antibody-drug conjugate (7)+Linker |
[250] | |
HK40112172A Antibody-drug conjugate (10) |
LT4212552T ADC10 payload |
DNA topoisomerase I (TOP1) |
HK40112172A+Antibody-drug conjugate (7)+Linker |
[250] | |
HK40112172A Antibody-drug conjugate (12) |
LT4212552T ADC13 payload |
DNA topoisomerase I (TOP1) |
Mc-Gly-Gly-Phe-Gly |
[250] | |
HK40112172A Antibody-drug conjugate (13) |
LT4212552T ADC13 payload |
DNA topoisomerase I (TOP1) |
Mc-Gly-Gly-Phe-Gly |
[250] | |
HK40112172A Antibody-drug conjugate (15) |
LT4212552T ADC13 payload |
DNA topoisomerase I (TOP1) |
Mc-Gly-Gly-Phe-Gly |
[250] | |
HK40112172A Antibody-drug conjugate (16) |
LT4212552T ADC13 payload |
DNA topoisomerase I (TOP1) |
Mc-Gly-Gly-Phe-Gly |
[250] | |
HK40112172A Antibody-drug conjugate (17) |
HK40112172A+Antibody-drug conjugate (17)+payload |
Undisclosed |
HK40112172A+Antibody-drug conjugate (17)+Linker |
[250] | |
HK40112172A Antibody-drug conjugate (18) |
HK40112172A+Antibody-drug conjugate (17)+payload |
Undisclosed |
HK40112172A+Antibody-drug conjugate (17)+Linker |
[250] | |
HK40112172A Antibody-drug conjugate (19) |
HK40112172A+Antibody-drug conjugate (17)+payload |
Undisclosed |
HK40112172A+Antibody-drug conjugate (17)+Linker |
[250] | |
HK40112172A Antibody-drug conjugate (20) |
HK40112172A+Antibody-drug conjugate (17)+payload |
Undisclosed |
HK40112172A+Antibody-drug conjugate (17)+Linker |
[250] | |
HK40112172A Antibody-drug conjugate (21) |
LT4212552T ADC10 payload |
DNA topoisomerase I (TOP1) |
HK40112172A+Antibody-drug conjugate (7)+Linker |
[250] | |
HK40112172A Antibody-drug conjugate (22) |
LT4212552T ADC10 payload |
DNA topoisomerase I (TOP1) |
HK40112172A+Antibody-drug conjugate (7)+Linker |
[250] | |
HK40112172A Antibody-drug conjugate (24) |
LT4212552T ADC25 payload |
DNA topoisomerase I (TOP1) |
Mc-Gly-Gly-Phe-Gly |
[250] | |
HK40112172A Antibody-drug conjugate (25) |
LT4212552T ADC25 payload |
DNA topoisomerase I (TOP1) |
Mc-Gly-Gly-Phe-Gly |
[250] | |
HK40112172A Antibody-drug conjugate (26) |
LT4212552T ADC49 payload |
DNA topoisomerase I (TOP1) |
Mc-Gly-Gly-Phe-Gly |
[250] | |
HK40112172A Antibody-drug conjugate (27) |
LT4212552T ADC49 payload |
DNA topoisomerase I (TOP1) |
Mc-Gly-Gly-Phe-Gly |
[250] | |
HK40112172A Antibody-drug conjugate (28) |
LT4212552T ADC49 payload |
DNA topoisomerase I (TOP1) |
Mc-Gly-Gly-Phe-Gly |
[250] | |
HK40112172A Antibody-drug conjugate (29) |
LT4212552T ADC49 payload |
DNA topoisomerase I (TOP1) |
Mc-Gly-Gly-Phe-Gly |
[250] | |
HK40112172A Antibody-drug conjugate (30) |
LT4212552T ADC49 payload |
DNA topoisomerase I (TOP1) |
Mc-Gly-Gly-Phe-Gly |
[250] | |
HK40112172A Antibody-drug conjugate (31) |
LT4212552T ADC49 payload |
DNA topoisomerase I (TOP1) |
Mc-Gly-Gly-Phe-Gly |
[250] | |
HK40112172A Antibody-drug conjugate (36) |
LT4212552T ADC49 payload |
DNA topoisomerase I (TOP1) |
SCHEMBL17022441 |
[250] | |
HK40112172A Antibody-drug conjugate (37) |
LT4212552T ADC37 payload |
DNA topoisomerase I (TOP1) |
SCHEMBL17022441 |
[250] | |
HK40112172A Antibody-drug conjugate (39) |
HK40112172A+Antibody-drug conjugate (39)+payload |
Undisclosed |
HK40112172A+Antibody-drug conjugate (39)+Linker |
[250] | |
HK40112172A Antibody-drug conjugate (40) |
HK40112172A+Antibody-drug conjugate (39)+payload |
Undisclosed |
HK40112172A+Antibody-drug conjugate (39)+Linker |
[250] | |
HK40112172A Antibody-drug conjugate (41) |
Topo1 inhibitor B |
DNA topoisomerase I (TOP1) |
Mc-Gly-Gly-Phe-Gly |
[250] | |
HK40112172A Antibody-drug conjugate (42) |
Topo1 inhibitor B |
DNA topoisomerase I (TOP1) |
Mc-Gly-Gly-Phe-Gly |
[250] | |
HK40112172A Antibody-drug conjugate (43) |
LT4212552T ADC49 payload |
DNA topoisomerase I (TOP1) |
HK40112172A+Antibody-drug conjugate (43)+Linker |
[250] | |
HK40112172A Antibody-drug conjugate (44) |
LT4212552T ADC49 payload |
DNA topoisomerase I (TOP1) |
HK40112172A+Antibody-drug conjugate (44)+Linker |
[250] | |
HK40112172A Antibody-drug conjugate (46) |
LT4212552T ADC49 payload |
DNA topoisomerase I (TOP1) |
Mc-Gly-Gly-Phe-Gly |
[250] | |
HK40112172A Antibody-drug conjugate (47) |
LT4212552T ADC49 payload |
DNA topoisomerase I (TOP1) |
Mc-Gly-Gly-Phe-Gly |
[250] | |
HK40112172A Antibody-drug conjugate (48) |
LT4212552T ADC49 payload |
DNA topoisomerase I (TOP1) |
Mc-Gly-Gly-Phe-Gly |
[250] | |
HK40112172A Antibody-drug conjugate (49) |
LT4212552T ADC49 payload |
DNA topoisomerase I (TOP1) |
Mc-Gly-Gly-Phe-Gly |
[250] | |
HK40112172A Antibody-drug conjugate (50) |
Undisclosed |
Undisclosed |
Undisclosed |
[250] | |
US20250018051A1 IaⅠ |
US20250018038A1+IaⅠ+payload |
Undisclosed |
Mc-Val-Cit-PABC |
[181] | |
US20250018051A1 IaⅡ |
US20250018038A1+IaⅠ+payload |
Undisclosed |
TW202436324A+ADC-2+Linker |
[181] | |
US20250018051A1 IaⅢ |
US20250018038A1+IaⅢ+payload |
Undisclosed |
Mc-Val-Cit-PABC |
[181] | |
US20250018051A1 IaⅣ |
US20250018038A1+IaⅣ+payload |
Undisclosed |
Mc-Val-Ala-PABC |
[181] | |
US20250018051A1 IaⅥ |
US20250018038A1+IaⅥ+payload |
Undisclosed |
Mc-Val-Cit-PABC |
[181] | |
US20250018051A1 IaⅧ |
US20250018038A1+IaⅦ+payload |
Undisclosed |
TW202436324A+ADC-2+Linker |
[181] | |
US20250018051A1 IaⅩ |
US20250018038A1+IaⅢ+payload |
Undisclosed |
Mc-Val-Cit-PABC |
[181] | |
US20250018051A1 Iaⅰ |
US20250018038A1+IaⅣ+payload |
Undisclosed |
Mc-Val-Ala-PABC |
[181] | |
US20250018051A1 IaⅰⅠ |
US20250018038A1+IaⅥ+payload |
Undisclosed |
Mc-Val-Cit-PABC |
[181] | |
US20250018051A1 IaⅰⅡ |
US20250018038A1+IaⅦ+payload |
Undisclosed |
Mc-Val-Ala-PABC |
[181] | |
US20250018051A1 IaⅰⅢ |
US20250018038A1+IaⅣ+payload |
Undisclosed |
Mc-Val-Cit-PABC |
[181] | |
US20250018051A1 IaⅰⅣ |
US20250018038A1+IaⅰⅣ+payload |
Undisclosed |
Mc-Val-Ala-PABC |
[181] | |
US20250018051A1 IaⅰⅥ |
US20250018038A1+IaⅣ+payload |
Undisclosed |
Mc-Val-Cit-PABC |
[181] | |
US20250018051A1 IaⅰⅦ |
US20250018038A1+IaⅣ+payload |
Undisclosed |
Mc-Val-Ala-PABC |
[181] | |
US11903948B2 I-1 |
Dolicatatin 5 |
Microtubule (MT) |
Undisclosed |
[251] | |
US11903948B2 I-2 |
Undisclosed |
Undisclosed |
Undisclosed |
[251] | |
US11903948B2 I-3 |
Undisclosed |
Undisclosed |
Undisclosed |
[251] | |
HER-E-36 |
WO2024020536A1+HER-E-36+payload |
Undisclosed |
WO2024020536A1+HER-E-36+Linker |
[252] | |
HER-E-37 |
WO2024020536A1+HER-E-37+payload |
Undisclosed |
Mc-Gly-Gly-Phe-Gly |
[252] | |
HER-E-39 |
WO2024020536A1+HER-E-37+payload |
Undisclosed |
Mc-Gly-Gly-Phe-Gly |
[252] | |
HER-E-40 |
WO2024020536A1+HER-E-37+payload |
Undisclosed |
Mc-Gly-Gly-Phe-Gly |
[252] | |
HER-E-44 |
WO2024020536A1+HER-E-44+payload |
Undisclosed |
WO2024020536A1+HER-E-44+Linker |
[252] | |
HER-E-46 |
WO2024020536A1+HER-E-44+payload |
Undisclosed |
Mc-Gly-Gly-Phe-Gly |
[252] | |
HER-E-48 |
WO2024020536A1+HER-E-48+payload |
Undisclosed |
WO2024020536A1+HER-E-48+Linker |
[252] | |
HER-E-49 |
WO2024020536A1+HER-E-37+payload |
Undisclosed |
WO2024020536A1+HER-E-49+Linker |
[252] | |
Trastuzumab-DXD (EP4183421A1) |
Exatecan |
DNA topoisomerase 1 (TOP1) |
EP4183421A1+Trastuzumab-DXD+Linker |
[253] | |
Trastuzumab-DDDXD |
Exatecan |
DNA topoisomerase 1 (TOP1) |
EP4183421A1+Trastuzumab-DDDXD+Linker |
[253] | |
JP2025004232A ADC9 |
undisclosed |
Undisclosed |
Undisclosed |
[254] | |
EP4227309A4 ADC-1 |
undisclosed |
Undisclosed |
Undisclosed |
[255] | |
EP4227309A4 ADC-2 |
undisclosed |
Undisclosed |
Undisclosed |
[255] | |
EP4227309A4 ADC-3 |
undisclosed |
Undisclosed |
Undisclosed |
[255] | |
EP4227309A4 ADC-4 |
undisclosed |
Undisclosed |
Undisclosed |
[255] | |
EP4227309A4 ADC-5 |
undisclosed |
Undisclosed |
Undisclosed |
[255] | |
EP4227309A4 ADC-6 |
undisclosed |
Undisclosed |
Undisclosed |
[255] | |
EP4227309A4 ADC-7 |
undisclosed |
Undisclosed |
Undisclosed |
[255] | |
EP4227309A4 ADC-8 |
undisclosed |
Undisclosed |
Undisclosed |
[255] | |
EP4227309A4 ADC-9 |
undisclosed |
Undisclosed |
Undisclosed |
[255] | |
EP4227309A4 ADC-10 |
undisclosed |
Undisclosed |
Undisclosed |
[255] | |
EP4227309A4 ADC-11 |
undisclosed |
Undisclosed |
Undisclosed |
[255] | |
EP4227309A4 ADC-12 |
undisclosed |
Undisclosed |
Undisclosed |
[255] | |
EP4227309A4 ADC-13 |
undisclosed |
Undisclosed |
Undisclosed |
[255] | |
EP4227309A4 ADC-14 |
undisclosed |
Undisclosed |
Undisclosed |
[255] | |
EP4227309A4 ADC-15 |
undisclosed |
Undisclosed |
Undisclosed |
[255] | |
EP4227309A4 ADC-16 |
undisclosed |
Undisclosed |
Undisclosed |
[255] | |
EP4227309A4 ADC-17 |
undisclosed |
Undisclosed |
Undisclosed |
[255] | |
EP4227309A4 ADC-18 |
undisclosed |
Undisclosed |
Undisclosed |
[255] | |
US11850287B2 IIIa |
Undisclosed |
Undisclosed |
Undisclosed |
[257] | |
US11850287B2 IIIb |
Undisclosed |
Undisclosed |
Undisclosed |
[257] | |
US11850287B2 IIIc |
Undisclosed |
Undisclosed |
Undisclosed |
[257] | |
US11850287B2 IIId |
Undisclosed |
Undisclosed |
Undisclosed |
[257] | |
WO2023232144A1ADC-6 |
WO2023232144A1, ADC-2, Payload |
DNA topoisomerase I (TOP1) |
WO2023232144A1, ADC-2, linker |
[15] | |
WO2023232144A1ADC22 |
WO2025015586A1, ADC22, Payload |
DNA topoisomerase I (TOP1) |
Mc-Val-Cit-PABC |
[81] | |
WO2023232144A1ADC23 |
WO2025015586A1, ADC23, Payload |
Toll-like receptor 7 (TLR7); Toll-like receptor 8 (TLR8) |
Mc-Val-Cit-PABC |
[81] | |
WO2023232144A1ADC24 |
WO2025015586A1, ADC24, Payload |
Toll-like receptor 7 (TLR7); Toll-like receptor 8 (TLR8) |
Mc-Val-Cit-PABC |
[81] | |
WO2023232144A1ADC25 |
WO2025015586A1, ADC25, Payload |
Toll-like receptor 7 (TLR7); Toll-like receptor 8 (TLR8) |
Mc-Val-Cit-PABC |
[81] | |
WO2023232144A1ADC30 |
WO2025015586A1, ADC25, Payload |
Toll-like receptor 7 (TLR7); Toll-like receptor 8 (TLR8) |
SMCC |
[81] | |
WO2023232144A1ADC32 |
WO2025015586A1, ADC22, Payload |
DNA topoisomerase I (TOP1) |
SMCC |
[81] | |
AU2023308528A1 ADC3 |
Exatecan |
DNA topoisomerase 1 (TOP1) |
Mal-amido-PEG8-acid |
[258] | |
AU2023308528A1 ADC5 |
4- ((S)-2- ((S)-2-amino-3-methylbutanamido)propanamido)benzyl ((1S,9S)-9-ethyl-5-fluoro-9-hydroxy-4-methyl-10,13-dioxo-2,3,9,10,13,15-hexahydro-1H,12H-benzo[de]pyrano[3',4':6,7]indolizino[1,2-b]quinolin-1-yl)carbamate |
DNA topoisomerase I (TOP1) |
Mal-amido-PEG8-acid |
[258] | |
AU2023308528A1 ADC1 |
PBD aromatic-amide derivative |
DNA topoisomerase I (TOP1) |
6-Maleimidocaproic acid |
[258] | |
AU2023308528A1 ADC2 |
PBD-butanamide derivative |
DNA topoisomerase I (TOP1) |
6-Maleimidocaproic acid |
[258] | |
AU2023308528A1 ADC7 |
N- (4- ((S)-2- ((S)-2-amino-3- methylbutanamido)propanamido)phenyl)-4- (4- (4- (4- (( (S)-2-methoxy-12-oxo-6a,7,8,9,10,12-hexahydrobenzo[e]pyrido[1,2-a][1,4]diazepin-3-yl)oxy)butanamido)-1-methyl-1H-pyrrole-2-carboxamido)phenyl)-1-methyl-1H-pyrrole-2-carboxamide |
DNA topoisomerase I (TOP1) |
(S)-75-oxo-76- (4- (3-tosyl-2- (tosylmethyl)propanoyl)benzamido) 2,5,8,11,14,17,20,23,26,29,32,35,38,41,44,47,50,53,56,59,62,65,68,71-tetracosaoxa-74 azanonaheptacontan-79-oic acid |
[258] | |
AU2023308528A1 ADC2 (DAR of 4) |
PBD-butanamide derivative |
DNA topoisomerase I (TOP1) |
6-Maleimidocaproic acid |
[258] | |
Trastuzumab-Compound 30 |
Exatecan |
DNA topoisomerase 1 (TOP1) |
Mal-amido-PEG8-acid |
[258] | |
AU2023279443A1 Example 1 |
U-030; Ac-Exatecan |
Undisclosed |
AU2023279443A1, Example 1, Linker |
[259] | |
AU2023279443A1 Example 2 |
U-031 |
Microtubule (MT) |
AU2023279443A1, Example 3, Linker |
[259] | |
AU2023279443A1 Example 3 |
U-030 |
DNA topoisomerase I (TOP1) |
AU2023279443A1, Example 4, Linker |
[259] | |
AU2023279443A1 Example 4 |
U-031 |
Microtubule (MT) |
AU2023279443A1, Example 4, Linker |
[259] | |
AU2023279443A1 Example 5 |
U-031 |
Microtubule (MT) |
AU2023279443A1, Example 5, Linker |
[259] | |
AU2023279443A1 Example 6 |
U-031; AU2023279443A1, Example 6, Paylaod |
Undisclosed |
AU2023279443A1, Example 4, Linker |
[259] | |
AU2023279443A1 Example 7 |
U-031; U-033 |
Undisclosed |
AU2023279443A1, Example 4, Linker |
[259] | |
AU2023279443A1 Example A1 |
Monomethyl auristatin E |
Microtubule (MT) |
Undisclosed |
[259] | |
AU2023279443A1 Example A2 |
U-030 |
DNA topoisomerase I (TOP1) |
Undisclosed |
[259] | |
AU2023279443A1 Example A3 |
U-031 |
Microtubule (MT) |
AU2023279443A1, Example A3, Linker |
[259] | |
AU2023279443A1 Example A4 |
U-003 |
Microtubule (MT) |
Undisclosed |
[259] | |
AU2023279443A1 Example A5 |
U-029 |
Microtubule (MT) |
Undisclosed |
[259] | |
AU2023279443A1 Example A6 |
Monomethyl auristatin E |
Microtubule (MT) |
AU2023279443A1, Example A6, Linker |
[259] | |
AU2023279443A1 Example A7 |
Monomethyl auristatin E |
Microtubule (MT) |
AU2023279443A1, Example A7, Linker |
[259] | |
AU2023279443A1 Example A8 |
Monomethyl auristatin E |
Microtubule (MT) |
RU20241285-9-linker |
[259] | |
AU2023279443A1 Example A9 |
U-036 |
Microtubule (MT) |
RU20241285-9-linker |
[259] | |
AU2023279443A1 Example A10 |
Ac-Exatecan |
DNA topoisomerase I (TOP1) |
AU2023279443A1, Example A10, Linker |
[259] | |
AU2023279443A1 Example A11 |
DX-8951 derivative (DXd) |
DNA topoisomerase 1 (TOP1) |
AU2023279443A1, Example A10, Linker |
[259] | |
AU2023279443A1 Example A12 |
U-035 |
Microtubule (MT) |
AU2023279443A1, Example A12, Linker |
[259] | |
AU2023279443A1 Example A13 |
DX-8951 derivative (DXd) |
DNA topoisomerase 1 (TOP1) |
AU2023279443A1, Example A13, Linker |
[259] | |
AU2023279443A1 Example A14 |
Eribulin |
Microtubule (MT) |
RU20241285-9-linker |
[259] | |
AU2023279443A1Example A15 |
U-031 |
Microtubule (MT) |
AU2023279443A1, Example A15, Linker |
[259] | |
AU2023279443A1 Example A16 |
Eribulin |
Microtubule (MT) |
AU2023279443A1, Example A16, Linker |
[259] | |
AU2023279443A1 Example A17 |
Eribulin |
Microtubule (MT) |
AU2023279443A1, Example A17, Linker |
[259] | |
AU2023279443A1 Example A18 |
Eribulin |
Microtubule (MT) |
AU2023279443A1, Example A18, Linker |
[259] | |
AU2023279443A1 Example A19 |
U-031 |
Microtubule (MT) |
AU2023279443A1, Example A19, Linker |
[259] | |
AU2023279443A1 Example A20 |
Topo1 inhibitor A |
DNA topoisomerase I (TOP1) |
AU2023279443A1, Example A12, Linker |
[259] | |
AU2023279443A1 Example A21 |
Eribulin |
Microtubule (MT) |
AU2023279443A1, Example A21, Linker |
[259] | |
AU2023279443A1 Example A22 |
Eribulin |
Microtubule (MT) |
AU2023279443A1, Example A22, Linker |
[259] | |
AU2023279443A1 Example A23 |
RU20241285-23-payload |
DNA topoisomerase I (TOP1) |
AU2023279443A1, Example A10, Linker |
[259] | |
AU2023279443A1 Example A24 |
RU20241285-23-payload |
DNA topoisomerase I (TOP1) |
AU2023279443A1, Example A24, Linker |
[259] | |
AU2023279443A1 Comparative Control Compound-1 |
Monomethyl auristatin E |
Microtubule (MT) |
Mc-Val-Cit-PABC |
[259] | |
AU2023279443A1 Comparative Control Compound-2 |
Eribulin |
Microtubule (MT) |
Mal-PEG2-Val-Cit-PAB |
[259] | |
CN113943310A ADC-1 |
D-D9 payload |
DNA topoisomerase I (TOP1) |
CN113943310A, ADC-1, Linker |
[260] | |
CN113943310A ADC-2 |
D-D10 payload |
DNA topoisomerase I (TOP1) |
CN113943310A, ADC-1, Linker |
[260] | |
CN113943310A ADC-3 |
D-D3 payload |
DNA topoisomerase I (TOP1) |
CN113943310A, ADC-1, Linker |
[260] | |
CN113943310A ADC-4 |
D-D4 payload |
DNA topoisomerase I (TOP1) |
CN113943310A, ADC-1, Linker |
[260] | |
CN113943310A ADC-5 |
D-D5 payload |
DNA topoisomerase I (TOP1) |
CN113943310A, ADC-1, Linker |
[260] | |
CN113943310A ADC-6 |
D-D6 payload |
DNA topoisomerase I (TOP1) |
CN113943310A, ADC-1, Linker |
[260] | |
CN113943310A ADC-7 |
D-D11 payload |
DNA topoisomerase I (TOP1) |
CN113943310A, ADC-1, Linker |
[260] | |
CN113943310A ADC-8 |
D-D12 payload |
DNA topoisomerase I (TOP1) |
CN113943310A, ADC-1, Linker |
[260] | |
CN113943310A ADC-9 |
D-D14 payload |
DNA topoisomerase I (TOP1) |
CN113943310A, ADC-1, Linker |
[260] | |
CN113943310A ADC-10 |
D-D1 payload |
DNA topoisomerase I (TOP1) |
CN113943310A, ADC-1, Linker |
[260] | |
CN113943310A ADC-11 |
WO2025015586A1, ADC25, Payload |
Toll-like receptor 7 (TLR7); Toll-like receptor 8 (TLR8) |
Mc-Gly-Gly-Phe-Gly |
[260] | |
CN113943310A ADC-12 |
WO2025015586A1, ADC25, Payload |
Toll-like receptor 7 (TLR7); Toll-like receptor 8 (TLR8) |
CN113943310A, ADC-12, Linker |
[260] | |
CN113943310A ADC-13 |
WO2025015586A1, ADC23, Payload |
Toll-like receptor 7 (TLR7); Toll-like receptor 8 (TLR8) |
CN113943310A, ADC-12, Linker |
[260] | |
CN113943310A ADC-14 |
compound 4 |
DNA topoisomerase I (TOP1) |
CN113943310A, ADC-12, Linker |
[260] | |
CN113943310A ADC-15 |
compound 5 |
DNA topoisomerase I (TOP1) |
CN113943310A, ADC-12, Linker |
[260] | |
CN113943310A ADC-16 |
WO2025015586A1, ADC24, Payload |
Toll-like receptor 7 (TLR7); Toll-like receptor 8 (TLR8) |
CN113943310A, ADC-12, Linker |
[260] | |
CN113943310A ADC-17 |
WO2025015586A1, ADC35, Payload |
Toll-like receptor 7 (TLR7); Toll-like receptor 8 (TLR8) |
CN113943310A, ADC-12, Linker |
[260] | |
CN113943310A ADC-18 |
WO2025015586A1, ADC34, Payload |
Toll-like receptor 7 (TLR7); Toll-like receptor 8 (TLR8) |
CN113943310A, ADC-12, Linker |
[260] | |
CN106714844B ADC-141 |
Mertansine DM1 |
Microtubule (MT) |
Succinimidyl-4- (N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC) |
[3] | |
Tras-1 |
US11141490B2-Tras-1-payload |
Undisclosed |
US11141490B2-Tras-1-linker |
[261] | |
Tras-4 |
US11141490B2-Tras-4-payload |
Undisclosed |
Ethylmaleimide linker |
[261] | |
CN110974975B C-01 |
Exatecan |
DNA topoisomerase 1 (TOP1) |
Coumpound7 |
[262] | |
CN110974975B C-06 |
Exatecan |
DNA topoisomerase 1 (TOP1) |
Coumpound15 |
[262] | |
CN110974975B C-07 |
Active metabolite of irinotecan SN38 |
DNA topoisomerase 1 (TOP1) |
Coumpound17 |
[262] | |
CN110974975B C-00 |
Monomethyl auristatin E |
Microtubule (MT) |
CN110974975B-C-00-linker |
[262] | |
CN116888123A ADC-1 |
D2 payload |
Undisclosed |
Mc-Gly-Gly-Phe-Gly |
[263] | |
CN116888123A ADC-2 |
D2 payload |
Undisclosed |
LA2 linker |
[263] | |
CN116888123A ADC-3 |
D2 payload |
Undisclosed |
LA2 linker |
[263] | |
CN116888123A ADC-4 |
D3 payload |
Undisclosed |
Mc-Gly-Gly-Phe-Gly |
[263] | |
CN116888123A ADC-5 |
D1 payload |
Undisclosed |
B1-b linker |
[263] | |
CN116888123A ADC-6 |
D1-SH payload |
Undisclosed |
LC1 linker |
[263] | |
CN116888123A ADC-7 |
D2 payload |
Undisclosed |
LD1 linker |
[263] | |
BCN-linker-Dxd1 |
DX-8951 derivative (DXd) |
DNA topoisomerase 1 (TOP1) |
BCN-linker |
[264] | |
BCN-linker-Dxd2 |
DX-8951 derivative (DXd) |
DNA topoisomerase 1 (TOP1) |
BCN-linker |
[264] | |
BCN-linker-Dxd3 |
DX-8951 derivative (DXd) |
DNA topoisomerase 1 (TOP1) |
BCN-linker |
[264] | |
BCN-linker-Dxd4 |
DX-8951 derivative (DXd) |
DNA topoisomerase 1 (TOP1) |
BCN-linker |
[264] | |
SMCC-calicheamicin-ADC |
Calicheamicin |
Undisclosed |
Succinimidyl-4- (N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC) |
[265] | |
SMPB-calicheamicin-ADC |
Calicheamicin |
Undisclosed |
Undisclosed |
[265] | |
AU2016292759A1 ADC-1 |
AU2016292759A1-ADC-1-payload |
Undisclosed |
AU2016292759A1-ADC-1-linker |
[266] | |
TrastuzumabA132TCO*A |
Undisclosed |
Undisclosed |
CN118574641A-TrastuzumabA132TCO*A-linker |
[267] | |
Trastuzumab-TCO*A-5 |
Undisclosed |
Undisclosed |
CN118574641A-Trastuzumab-TCO*A-5-linker |
[267] | |
Trastuzumab-TCO*A-11 |
Undisclosed |
Undisclosed |
CN118574641A-Trastuzumab-TCO*A-11-linker |
[267] | |
US20240148889A1 ADC-1 |
US20240148889A1-ADC-1-payload |
Undisclosed |
US20240148889A1-ADC-1-linker |
[268] | |
TWI870307BAntibody-drug conjugate (2) |
LT4212552T ADC10 payload |
DNA topoisomerase I (TOP1) |
Mc-Gly-Gly-Phe-Gly |
[269] | |
TWI870307BAntibody-drug conjugate (3) |
LT4212552T ADC10 payload |
DNA topoisomerase I (TOP1) |
Mc-Gly-Gly-Phe-Gly |
[269] | |
TWI870307BAntibody-drug conjugate (4) |
LT4212552T ADC10 payload |
DNA topoisomerase I (TOP1) |
TWI870307BAntibody-drug conjugate (4)Linker |
[269] | |
TWI870307BAntibody-drug conjugate (5) |
LT4212552T ADC10 payload |
DNA topoisomerase I (TOP1) |
TWI870307BAntibody-drug conjugate (4)Linker |
[269] | |
TWI870307BAntibody-drug conjugate (6) |
LT4212552T ADC10 payload |
DNA topoisomerase I (TOP1) |
TWI870307BAntibody-drug conjugate (6)Linker |
[269] | |
TWI870307BAntibody-drug conjugate (7) |
LT4212552T ADC10 payload |
DNA topoisomerase I (TOP1) |
TWI870307BAntibody-drug conjugate (6)Linker |
[269] | |
TWI870307BAntibody-drug conjugate (8) |
LT4212552T ADC10 payload |
DNA topoisomerase I (TOP1) |
TWI870307BAntibody-drug conjugate (6)Linker |
[269] | |
TWI870307BAntibody-drug conjugate (9) |
LT4212552T ADC10 payload |
DNA topoisomerase I (TOP1) |
TWI870307BAntibody-drug conjugate (9)Linker |
[269] | |
TWI870307BAntibody-drug conjugate (10) |
LT4212552T ADC10 payload |
DNA topoisomerase I (TOP1) |
TWI870307BAntibody-drug conjugate (9)Linker |
[269] | |
TWI870307BAntibody-drug conjugate (12) |
TWI870307BAntibody-drug conjugate (12)Payload |
Undisclosed |
Mc-Gly-Gly-Phe-Gly |
[269] | |
TWI870307BAntibody-drug conjugate (13) |
TWI870307BAntibody-drug conjugate (12)Payload |
Undisclosed |
Mc-Gly-Gly-Phe-Gly |
[269] | |
TWI870307BAntibody-drug conjugate (15) |
TWI870307BAntibody-drug conjugate (12)Payload |
Undisclosed |
Mc-Gly-Gly-Phe-Gly |
[269] | |
TWI870307BAntibody-drug conjugate (16) |
TWI870307BAntibody-drug conjugate (12)Payload |
Undisclosed |
Mc-Gly-Gly-Phe-Gly |
[269] | |
TWI870307BAntibody-drug conjugate (17) |
TWI870307BAntibody-drug conjugate (12)Payload |
Undisclosed |
LT4212552T-ADC-5-LINKER |
[269] | |
TWI870307BAntibody-drug conjugate (18) |
TWI870307BAntibody-drug conjugate (12)Payload |
Undisclosed |
LT4212552T-ADC-5-LINKER |
[269] | |
TWI870307BAntibody-drug conjugate (19) |
TWI870307BAntibody-drug conjugate (12)Payload |
Undisclosed |
HK40112172A+Antibody-drug conjugate (19)+Linker |
[269] | |
TWI870307BAntibody-drug conjugate (20) |
TWI870307BAntibody-drug conjugate (12)Payload |
Undisclosed |
HK40112172A+Antibody-drug conjugate (19)+Linker |
[269] | |
TWI870307BAntibody-drug conjugate (21) |
TWI870307BAntibody-drug conjugate (12)Payload |
Undisclosed |
TWI870307BAntibody-drug conjugate (21)Linker |
[269] | |
TWI870307BAntibody-drug conjugate (22) |
TWI870307BAntibody-drug conjugate (12)Payload |
Undisclosed |
TWI870307BAntibody-drug conjugate (21)Linker |
[269] | |
TWI870307BAntibody-drug conjugate (24) |
LT4212552T ADC25 payload |
DNA topoisomerase I (TOP1) |
Mc-Gly-Gly-Phe-Gly |
[269] | |
TWI870307BAntibody-drug conjugate (25) |
LT4212552T ADC25 payload |
DNA topoisomerase I (TOP1) |
Mc-Gly-Gly-Phe-Gly |
[269] | |
TWI870307BAntibody-drug conjugate (26) |
TWI870307BAntibody-drug conjugate (26)Payload |
Undisclosed |
TWI870307BAntibody-drug conjugate (26)Linker |
[269] | |
TWI870307BAntibody-drug conjugate (27) |
TWI870307BAntibody-drug conjugate (26)Payload |
Undisclosed |
TWI870307BAntibody-drug conjugate (26)Linker |
[269] | |
TWI870307BAntibody-drug conjugate (28) |
TWI870307BAntibody-drug conjugate (26)Payload |
Undisclosed |
TWI870307BAntibody-drug conjugate (26)Linker |
[269] | |
TWI870307BAntibody-drug conjugate (29) |
TWI870307BAntibody-drug conjugate (26)Payload |
Undisclosed |
TWI870307BAntibody-drug conjugate (26)Linker |
[269] | |
TWI870307BAntibody-drug conjugate (30) |
TWI870307BAntibody-drug conjugate (26)Payload |
Undisclosed |
TWI870307BAntibody-drug conjugate (26)Linker |
[269] | |
TWI870307BAntibody-drug conjugate (31) |
TWI870307BAntibody-drug conjugate (26)Payload |
Undisclosed |
TWI870307BAntibody-drug conjugate (26)Linker |
[269] | |
TWI870307BAntibody-drug conjugate (36) |
LT4212552T ADC37 payload |
DNA topoisomerase I (TOP1) |
TWI870307BAntibody-drug conjugate (36)Linker |
[269] | |
TWI870307BAntibody-drug conjugate (37) |
LT4212552T ADC37 payload |
DNA topoisomerase I (TOP1) |
TWI870307BAntibody-drug conjugate (36)Linker |
[269] | |
TWI870307BAntibody-drug conjugate (39) |
TWI870307BAntibody-drug conjugate (39)Payload |
Undisclosed |
TWI870307BAntibody-drug conjugate (39)Linker |
[269] | |
TWI870307BAntibody-drug conjugate (40) |
TWI870307BAntibody-drug conjugate (39)Payload |
Undisclosed |
TWI870307BAntibody-drug conjugate (39)Linker |
[269] | |
TWI870307BAntibody-drug conjugate (41) |
Topo1 inhibitor B |
DNA topoisomerase I (TOP1) |
Mc-Gly-Gly-Phe-Gly |
[269] | |
TWI870307BAntibody-drug conjugate (42) |
Topo1 inhibitor B |
DNA topoisomerase I (TOP1) |
Mc-Gly-Gly-Phe-Gly |
[269] | |
TWI870307BAntibody-drug conjugate (43) |
LT4212552T ADC49 payload |
DNA topoisomerase I (TOP1) |
TWI870307BAntibody-drug conjugate (6)Linker |
[269] | |
TWI870307BAntibody-drug conjugate (44) |
TWI870307BAntibody-drug conjugate (44)Payload |
Undisclosed |
TWI870307BAntibody-drug conjugate (44)Linker |
[269] | |
TWI870307BAntibody-drug conjugate (46) |
Undisclosed |
Undisclosed |
Mc-Gly-Gly-Phe-Gly |
[269] | |
TWI870307BAntibody-drug conjugate (47) |
Undisclosed |
Undisclosed |
Mc-Gly-Gly-Phe-Gly |
[269] | |
TWI870307BAntibody-drug conjugate (48) |
Undisclosed |
Undisclosed |
Mc-Gly-Gly-Phe-Gly |
[269] | |
TWI870307BAntibody-drug conjugate (49) |
Undisclosed |
Undisclosed |
Mc-Gly-Gly-Phe-Gly |
[269] | |
TWI870307BAntibody-drug conjugate (50) |
Undisclosed |
Undisclosed |
Mc-Gly-Gly-Phe-Gly |
[269] | |
KR102754055B1 ADCProductionexampleNo.1 |
ADCProductionexampleNo.1Payload |
Undisclosed |
Mc-Val-Cit-PABC |
[89] | |
KR102754055B1 ADCProductionexampleNo.2 |
ADCProductionexampleNo.2Payload |
Undisclosed |
ADCProductionexampleNo.2Linker |
[89] | |
KR102754055B1 ADCProductionexampleNo.3a |
ADCProductionexampleNo.3aPayload |
Undisclosed |
ADCProductionexampleNo.3aLinker |
[89] | |
KR102754055B1 ADCProductionexampleNo.3b |
ADCProductionexampleNo.3bPayload |
Undisclosed |
ADCProductionexampleNo.3aLinker |
[89] | |
KR102754055B1 ADCProductionexampleNo.3c |
ADCProductionexampleNo.3cPayload |
Undisclosed |
ADCProductionexampleNo.3aLinker |
[89] | |
KR102754055B1 ADCProductionexampleNo.4 |
ADCProductionexampleNo.4Payload |
Undisclosed |
ADCProductionexampleNo.4Linker |
[89] | |
KR102754055B1 ADCProductionexampleNo.5 |
ADCProductionexampleNo.5Payload |
Undisclosed |
RU20241285-4-linker |
[89] | |
KR102754055B1 ADCProductionexampleNo.6 |
ADCProductionexampleNo.6Payload |
Undisclosed |
ADCProductionexampleNo.6Linker |
[89] | |
KR102754055B1 ADCProductionexampleNo.7 |
ADCProductionexampleNo.7Payload |
Undisclosed |
ADCProductionexampleNo.7Linker |
[89] | |
KR102754055B1 ADCProductionexampleNo.8 |
ADCProductionexampleNo.8Payload |
Undisclosed |
ADCProductionexampleNo.8Linker |
[89] | |
KR102754055B1 ADCProductionexampleNo.9 |
ADCProductionexampleNo.9Payload |
Undisclosed |
ADCProductionexampleNo.9Linker |
[89] | |
KR102754055B1 ADCProductionexampleNo.10 |
ADCProductionexampleNo.10Payload |
Undisclosed |
ADCProductionexampleNo.10Linker |
[89] | |
KR102754055B1 ADCProductionexampleNo.11 |
ADCProductionexampleNo.11Payload |
Undisclosed |
ADCProductionexampleNo.11Linker |
[89] | |
KR102754055B1 ADCProductionexampleNo.12 |
ADCProductionexampleNo.12Payload |
Undisclosed |
ADCProductionexampleNo.8Linker |
[89] | |
KR102754055B1 ADCProductionexampleNo.13 |
ADCProductionexampleNo.13Payload |
Undisclosed |
ADCProductionexampleNo.13Linker |
[89] | |
KR102754055B1 ADCProductionexampleNo.14 |
Undisclosed |
Undisclosed |
ADCProductionexampleNo.15Linker |
[89] | |
KR102754055B1 ADCProductionexampleNo.15 |
ADCProductionexampleNo.15Payload |
Undisclosed |
ADCProductionexampleNo.15Linker |
[89] | |
KR102754055B1 ADCProductionexampleNo.16 |
ADCProductionexampleNo.16Payload |
Undisclosed |
ADCProductionexampleNo.16Linker |
[89] | |
KR102754055B1 ADCProductionexampleNo.17 |
ADCProductionexampleNo.17Payload |
Undisclosed |
ADCProductionexampleNo.17Linker |
[89] | |
KR102754055B1 ADCProductionexampleNo.18 |
ADCProductionexampleNo.18Payload |
Undisclosed |
ADCProductionexampleNo.18Linker |
[89] | |
KR102754055B1 ADCProductionexampleNo.19 |
ADCProductionexampleNo.19Payload |
Undisclosed |
ADCProductionexampleNo.19Linker |
[89] | |
KR102754055B1 ADCProductionexampleNo.20 |
ADCProductionexampleNo.20Payload |
Undisclosed |
ADCProductionexampleNo.20Linker |
[89] | |
KR102754055B1 ADCProductionexampleNo.21 |
ADCProductionexampleNo.20Payload |
Undisclosed |
ADCProductionexampleNo.20Linker |
[89] | |
KR102754055B1 ADCProductionexampleNo.22 |
ADCProductionexampleNo.20Payload |
Undisclosed |
ADCProductionexampleNo.20Linker |
[89] | |
KR102754055B1 ADCProductionexampleNo.23 |
Undisclosed |
Undisclosed |
Undisclosed |
[89] | |
KR102754055B1 ADCProductionexampleNo.24 |
Undisclosed |
Undisclosed |
Undisclosed |
[89] | |
CH-2-589 |
Undisclosed |
Undisclosed |
Undisclosed |
[89] | |
CH-2-593 |
Undisclosed |
Undisclosed |
Undisclosed |
[270] | |
CH-2-518 |
Undisclosed |
Undisclosed |
Undisclosed |
[270] | |
LC302-2-1 |
Undisclosed |
Undisclosed |
Undisclosed |
[270] | |
LC302-2-4 (4) 3.41 |
Undisclosed |
Undisclosed |
Undisclosed |
[270] | |
IN202417100055A Reference Example A1 |
Undisclosed |
Undisclosed |
Undisclosed |
[271] | |
IN202417100055A Reference Example A2 |
Undisclosed |
Undisclosed |
Undisclosed |
[271] | |
IN202417100055A Reference Example A3 |
Undisclosed |
Undisclosed |
Undisclosed |
[271] | |
IN202417100055A Reference Example A3b |
Undisclosed |
Undisclosed |
Undisclosed |
[271] | |
IN202417100055A Reference Example A3c |
Undisclosed |
Undisclosed |
Undisclosed |
[271] | |
IN202417100055A Reference Example A4 |
Undisclosed |
Undisclosed |
Undisclosed |
[271] | |
IN202417100055A Reference Example A5 |
Undisclosed |
Undisclosed |
Undisclosed |
[271] | |
IN202417100055A Reference Example A6 |
Undisclosed |
Undisclosed |
Undisclosed |
[271] | |
IN202417100055A Reference Example A7 |
Undisclosed |
Undisclosed |
Undisclosed |
[271] | |
IN202417100055A Reference Example A8 |
Undisclosed |
Undisclosed |
Undisclosed |
[271] | |
IN202417100055A Reference Example A9 |
Undisclosed |
Undisclosed |
Undisclosed |
[271] | |
IN202417100055A Reference Example A10 |
Undisclosed |
Undisclosed |
Undisclosed |
[271] | |
IN202417100055A Reference Example A11 |
Undisclosed |
Undisclosed |
Undisclosed |
[271] | |
IN202417100055A Reference Example A12 |
Undisclosed |
Undisclosed |
Undisclosed |
[271] | |
IN202417100055A Reference Example A13 |
Undisclosed |
Undisclosed |
Undisclosed |
[271] | |
IN202417100055A Reference Example A14 |
Undisclosed |
Undisclosed |
Undisclosed |
[271] | |
IN202417100055A Reference Example A15 |
Undisclosed |
Undisclosed |
Undisclosed |
[271] | |
IN202417100055A Reference Example A16 |
Undisclosed |
Undisclosed |
Undisclosed |
[271] | |
IN202417100055A Reference Example A17 |
Undisclosed |
Undisclosed |
Undisclosed |
[271] | |
IN202417100055A Reference Example A18 |
Undisclosed |
Undisclosed |
Undisclosed |
[271] | |
IN202417100055A Reference Example A19 |
Undisclosed |
Undisclosed |
Undisclosed |
[271] | |
IN202417100055A Reference Example A20 |
Undisclosed |
Undisclosed |
Undisclosed |
[271] | |
IN202417100055A Reference Example A21 |
Undisclosed |
Undisclosed |
Undisclosed |
[271] | |
IN202417100055A Reference Example A22 |
Undisclosed |
Undisclosed |
Undisclosed |
[271] | |
IN202417100055A Reference Example A23 |
Undisclosed |
Undisclosed |
Undisclosed |
[271] | |
IN202417100055A Reference Example A24 |
Undisclosed |
Undisclosed |
Undisclosed |
[271] | |
IN202417100055A Reference Example A25 |
Undisclosed |
Undisclosed |
Undisclosed |
[271] | |
IN202417100055A Reference Example A26 |
Undisclosed |
Undisclosed |
Undisclosed |
[271] | |
IN202417100055A Reference Example 1 |
Undisclosed |
Undisclosed |
Undisclosed |
[271] | |
IN202417100055A Reference Example 2 |
Undisclosed |
Undisclosed |
Undisclosed |
[271] | |
IN202417100055A Reference Example 3 |
Undisclosed |
Undisclosed |
Undisclosed |
[271] | |
IN202417100055A Reference Example 4 |
Undisclosed |
Undisclosed |
Undisclosed |
[271] | |
IN202417100055A Reference Example 5 |
Undisclosed |
Undisclosed |
Undisclosed |
[271] | |
IN202417100055A Reference Example 6 |
Undisclosed |
Undisclosed |
Undisclosed |
[271] | |
IN202417100055A Reference Example 7 |
Undisclosed |
Undisclosed |
Undisclosed |
[272] | |
CN115594732A I-LD011 |
undisclosed |
Undisclosed |
Undisclosed |
[273] | |
CN115594732A I-LD012 |
undisclosed |
Undisclosed |
Undisclosed |
[273] | |
CN115594732A I-LD013 |
undisclosed |
Undisclosed |
Undisclosed |
[273] | |
CN115594732A I-LD014 |
undisclosed |
Undisclosed |
Undisclosed |
[273] | |
CN115594732A I-LD015 |
undisclosed |
Undisclosed |
Undisclosed |
[273] | |
CN115594732A I-LD016 |
undisclosed |
Undisclosed |
Undisclosed |
[273] | |
CN115594732A I-LD017 |
undisclosed |
Undisclosed |
Undisclosed |
[273] | |
CN115594732A I-LD018A |
undisclosed |
Undisclosed |
Undisclosed |
[273] | |
CN115594732A I-LD018B |
undisclosed |
Undisclosed |
Undisclosed |
[273] | |
CN115594732A I-LD019 |
undisclosed |
Undisclosed |
Undisclosed |
[273] | |
CN115594732A I-LD020 |
undisclosed |
Undisclosed |
Undisclosed |
[273] | |
CN115594732A I-LD021 |
undisclosed |
Undisclosed |
Undisclosed |
[273] | |
CN115594732A II-LD-011 |
undisclosed |
Undisclosed |
Undisclosed |
[273] | |
CN115594732A II-LD-012 |
undisclosed |
Undisclosed |
Undisclosed |
[273] | |
CN115594732A II-LD-013 |
undisclosed |
Undisclosed |
Undisclosed |
[273] | |
CN115594732A II-LD-014 |
undisclosed |
Undisclosed |
Undisclosed |
[273] | |
CN115594732A II-LD-015 |
undisclosed |
Undisclosed |
Undisclosed |
[273] | |
CN115594732A II-LD-016 |
undisclosed |
Undisclosed |
Undisclosed |
[273] | |
CN115594732A II-LD-017 |
undisclosed |
Undisclosed |
Undisclosed |
[273] | |
CN115594732A II-LD-018 |
undisclosed |
Undisclosed |
Undisclosed |
[273] | |
CN115594732A II-LD-019 |
undisclosed |
Undisclosed |
Undisclosed |
[273] | |
CN118873678A ADC-1 |
undisclosed |
Undisclosed |
Undisclosed |
[274] | |
CN118873678A ADC-2 |
Undisclosed |
Undisclosed |
Undisclosed |
[274] | |
CN118873678A ADC-3 |
Undisclosed |
Undisclosed |
Undisclosed |
[274] | |
CN118873678A ADC-4 |
undisclosed |
Undisclosed |
Undisclosed |
[274] | |
CN118873678A ADC-5 |
Undisclosed |
Undisclosed |
Undisclosed |
[274] | |
CN118873678A ADC-6 |
Undisclosed |
Undisclosed |
Undisclosed |
[274] | |
CN118873678A ADC-7 |
Undisclosed |
Undisclosed |
Undisclosed |
[274] | |
CN118873678A ADC-8 |
Undisclosed |
Undisclosed |
Undisclosed |
[274] | |
CN118873678A ADC-9 |
Undisclosed |
Undisclosed |
Undisclosed |
[274] | |
CN118873678A ADC-10 |
Undisclosed |
Undisclosed |
Undisclosed |
[274] | |
CN118873678A ADC-11 |
undisclosed |
Undisclosed |
Undisclosed |
[274] | |
CN118873678A ADC-12 |
undisclosed |
Undisclosed |
Undisclosed |
[274] | |
CN118873678A ADC-13 |
undisclosed |
Undisclosed |
Undisclosed |
[274] | |
CN118873678A ADC-14 |
undisclosed |
Undisclosed |
Undisclosed |
[274] | |
LT4212552T ADC-2 |
LT4212552T-ADC-2-PAYLOAD |
Undisclosed |
Mc-Gly-Gly-Phe-Gly |
[275] | |
LT4212552T ADC-3 |
LT4212552T ADC10 payload |
DNA topoisomerase I (TOP1) |
Mc-Gly-Gly-Phe-Gly |
[275] | |
LT4212552T ADC4 |
LT4212552T-ADC-4-PAYLOAD |
Undisclosed |
Mc-Gly-Gly-Phe-Gly |
[275] | |
LT4212552T ADC5 |
LT4212552T ADC10 payload |
DNA topoisomerase I (TOP1) |
LT4212552T-ADC-5-LINKER |
[275] | |
LT4212552T ADC6 |
LT4212552T-ADC-6-PAYLOAD |
Undisclosed |
LT4212552T-ADC-6-LINKER |
[275] | |
LT4212552T ADC7 |
LT4212552T ADC10 payload |
DNA topoisomerase I (TOP1) |
LT4212552T-ADC-7-LINKER |
[275] | |
LT4212552T ADC8 |
LT4212552T ADC10 payload |
DNA topoisomerase I (TOP1) |
LT4212552T-ADC-8-LINKER |
[275] | |
LT4212552T ADC9 |
LT4212552T ADC10 payload |
DNA topoisomerase I (TOP1) |
LT4212552T-ADC-9-LINKER |
[275] | |
LT4212552T ADC10 |
LT4212552T ADC10 payload |
DNA topoisomerase I (TOP1) |
LT4212552T-ADC-10-LINKER |
[275] | |
LT4212552T ADC12 |
LT4212552T-ADC-12-PAYLOAD |
Undisclosed |
Mc-Gly-Gly-Phe-Gly |
[275] | |
LT4212552T ADC13 |
LT4212552T ADC13 payload |
DNA topoisomerase I (TOP1) |
Mc-Gly-Gly-Phe-Gly |
[275] | |
LT4212552T ADC15 |
LT4212552T ADC37 payload |
DNA topoisomerase I (TOP1) |
Undisclosed |
[275] | |
LT4212552T ADC16 |
LT4212552T ADC37 payload |
DNA topoisomerase I (TOP1) |
Undisclosed |
[275] | |
LT4212552T ADC17 |
LT4212552T ADC37 payload |
DNA topoisomerase I (TOP1) |
LT4212552T-ADC-17-LINKER |
[275] | |
LT4212552T ADC18 |
LT4212552T ADC37 payload |
DNA topoisomerase I (TOP1) |
LT4212552T-ADC-17-LINKER |
[275] | |
LT4212552T ADC19 |
LT4212552T ADC37 payload |
DNA topoisomerase I (TOP1) |
LT4212552T-ADC-19-LINKER |
[275] | |
LT4212552T ADC20 |
LT4212552T ADC37 payload |
DNA topoisomerase I (TOP1) |
LT4212552T-ADC-19-LINKER |
[275] | |
LT4212552T ADC21 |
LT4212552T ADC37 payload |
DNA topoisomerase I (TOP1) |
LT4212552T-ADC-21-LINKER |
[275] | |
LT4212552T ADC22 |
LT4212552T ADC37 payload |
DNA topoisomerase I (TOP1) |
LT4212552T-ADC-21-LINKER |
[275] | |
LT4212552T ADC24 |
LT4212552T ADC25 payload |
DNA topoisomerase I (TOP1) |
LT4212552T-ADC-24-LINKER |
[275] | |
LT4212552T ADC25 |
LT4212552T ADC25 payload |
DNA topoisomerase I (TOP1) |
LT4212552T-ADC-24-LINKER |
[275] | |
LT4212552T ADC26 |
LT4212552T ADC49 payload |
DNA topoisomerase I (TOP1) |
Mc-Gly-Gly-Phe-Gly |
[275] | |
LT4212552T ADC27 |
LT4212552T ADC49 payload |
DNA topoisomerase I (TOP1) |
Mc-Gly-Gly-Phe-Gly |
[275] | |
LT4212552T ADC28 |
LT4212552T ADC49 payload |
DNA topoisomerase I (TOP1) |
Mc-Gly-Gly-Phe-Gly |
[275] | |
LT4212552T ADC29 |
LT4212552T ADC49 payload |
DNA topoisomerase I (TOP1) |
Mc-Gly-Gly-Phe-Gly |
[275] | |
LT4212552T ADC30 |
LT4212552T ADC49 payload |
DNA topoisomerase I (TOP1) |
Mc-Gly-Gly-Phe-Gly |
[275] | |
LT4212552T ADC31 |
LT4212552T ADC49 payload |
DNA topoisomerase I (TOP1) |
Mc-Gly-Gly-Phe-Gly |
[275] | |
LT4212552T ADC36 |
LT4212552T ADC37 payload |
DNA topoisomerase I (TOP1) |
LT4212552T-ADC-36-LINKER |
[275] | |
LT4212552T ADC37 |
LT4212552T ADC37 payload |
DNA topoisomerase I (TOP1) |
LT4212552T-ADC-36-LINKER |
[275] | |
LT4212552T ADC39 |
LT4212552T-ADC-39-PAYLOAD |
Undisclosed |
Mc-Gly-Gly-Phe-Gly |
[275] | |
LT4212552T ADC40 |
LT4212552T-ADC-39-PAYLOAD |
Undisclosed |
Mc-Gly-Gly-Phe-Gly |
[275] | |
LT4212552T ADC41 |
Topo1 inhibitor B |
DNA topoisomerase I (TOP1) |
Mc-Gly-Gly-Phe-Gly |
[275] | |
LT4212552T ADC42 |
Topo1 inhibitor B |
DNA topoisomerase I (TOP1) |
Mc-Gly-Gly-Phe-Gly |
[275] | |
LT4212552T ADC43 |
LT4212552T ADC49 payload |
DNA topoisomerase I (TOP1) |
LT4212552T-ADC-6-LINKER |
[275] | |
LT4212552T ADC44 |
LT4212552T ADC49 payload |
DNA topoisomerase I (TOP1) |
HK40112172A+Antibody-drug conjugate (44)+Linker |
[275] | |
LT4212552T ADC46 |
LT4212552T ADC49 payload |
DNA topoisomerase I (TOP1) |
Mc-Gly-Gly-Phe-Gly |
[275] | |
LT4212552T ADC47 |
LT4212552T ADC49 payload |
DNA topoisomerase I (TOP1) |
Mc-Gly-Gly-Phe-Gly |
[275] | |
LT4212552T ADC49 |
LT4212552T ADC49 payload |
DNA topoisomerase I (TOP1) |
Mc-Gly-Gly-Phe-Gly |
[275] | |
Herceptin-RTX-5007 |
Undisclosed |
Undisclosed |
Undisclosed |
[276] | |
IGAC-1 |
IG-L-1 Payload |
Undisclosed |
IG-L-1 linker |
[277] | |
IGAC-3 |
Smol006 |
Eukaryotic peptide chain release factor GTP-binding subunit ERF3A (GSPT1) |
MP-Ala-Ala-PAB |
[277] | |
IGAC-5 |
IG-L-2 Payload |
Undisclosed |
MP-Ala-Ala-PAB |
[277] | |
IGAC-7 |
Smol006 |
Eukaryotic peptide chain release factor GTP-binding subunit ERF3A (GSPT1) |
MP-Ala-Ala-PAB |
[277] | |
IGAC-9 |
IG-L-1 Payload |
Undisclosed |
IG-L-1 linker |
[277] | |
IGAC-11 |
IG-L-3 Payload |
Undisclosed |
IG-L-3 linker |
[277] | |
IGAC-13 |
IG-L-7 Payload |
Undisclosed |
MP-Ala-Ala-PAB |
[277] | |
IGAC-15 |
IG-L-4 Payload |
Undisclosed |
MP-Ala-Ala-PAB |
[277] | |
IGAC-17 |
IG-L-5 Payload |
Undisclosed |
MP-Ala-Ala-PAB |
[277] | |
IGAC-19 |
IG-L-9 Payload |
Undisclosed |
MP-Ala-Ala-PAB |
[277] | |
IGAC-21 |
IG-L-10 Payload |
Undisclosed |
MP-Ala-Ala-PAB |
[277] | |
IGAC-23 |
IG-L-11 Payload |
Undisclosed |
MP-Ala-Ala-PAB |
[277] | |
IGAC-29 |
IG-L-12 Payload |
Undisclosed |
MP-Ala-Ala-PAB |
[277] | |
IGAC-31 |
Smol006 |
Eukaryotic peptide chain release factor GTP-binding subunit ERF3A (GSPT1) |
IG-L-14 linker |
[277] | |
IGAC-33 |
IG-L-16 Payload |
Undisclosed |
IG-L-16 linker |
[277] | |
IGAC-35 |
IG-L-17 Payload |
Undisclosed |
MP-Ala-Ala-PAB |
[277] | |
IGAC-36 |
IG-L-13 Payload |
Undisclosed |
IG-L-13 linker |
[277] | |
IGAC-37 |
IG-L-15 Payload |
Undisclosed |
DL18 linker |
[277] | |
IGAC-39 |
Smol006 |
Eukaryotic peptide chain release factor GTP-binding subunit ERF3A (GSPT1) |
MP-Ala-Ala-PAB |
[277] | |
IGAC-40 |
IG-L-18 Payload |
Undisclosed |
IG-L-18 linker |
[277] | |
IGAC-41 |
undisclosed |
Undisclosed |
IG-L-19 linker |
[277] | |
IGAC-42 |
IG-L-18 Payload |
Undisclosed |
IG-L-20 linker |
[277] | |
IGAC-43 |
IG-L-18 Payload |
Undisclosed |
IG-L-21 linker |
[277] | |
IGAC-44 |
IG-L-18 Payload |
Undisclosed |
IG-L-22 linker |
[277] | |
IGAC-47 |
IG-L-26 Payload |
Undisclosed |
IG-L-26 linker |
[277] | |
IGAC-48 |
IG-L-23 Payload |
Undisclosed |
IG-L-3 linker |
[277] | |
IGAC-49 |
IG-L-18 Payload |
Undisclosed |
IG-L-25 linker |
[277] | |
IGAC-50 |
IG-L-36 Payload |
Undisclosed |
IG-L-36 linker |
[277] | |
IGAC-52 |
IG-L-36 Payload |
Undisclosed |
IG-L-37 linker |
[277] | |
IGAC-54 |
IG-L-38 Payload |
Undisclosed |
IG-L-38 linker |
[277] | |
IGAC-55 |
IG-L-39 Payload |
Undisclosed |
IG-L-38 linker |
[277] | |
IGAC-56 |
IG-L-79 Payload |
Undisclosed |
IG-L-47 linker |
[277] | |
IGAC-57 |
Smol006 |
Eukaryotic peptide chain release factor GTP-binding subunit ERF3A (GSPT1) |
IG-L-16 linker |
[277] | |
IGAC-58 |
Smol006 |
Eukaryotic peptide chain release factor GTP-binding subunit ERF3A (GSPT1) |
IG-L-63 linker |
[277] | |
IGAC-60 |
CC-885 |
Undisclosed |
IG-L-54 linker |
[277] | |
IGAC-61 |
CC-885 |
Undisclosed |
IG-L-58 linker |
[277] | |
IGAC-63 |
IG-L-79 Payload |
Undisclosed |
IG-L-46 linker |
[277] | |
IGAC-65 |
Smol006 |
Eukaryotic peptide chain release factor GTP-binding subunit ERF3A (GSPT1) |
IG-L-65 linker |
[277] | |
IGAC-68 |
IG-L-71 Payload |
Undisclosed |
IG-L-71 linker |
[277] | |
IGAC-69 |
Smol006 |
Eukaryotic peptide chain release factor GTP-binding subunit ERF3A (GSPT1) |
IG-L-68 linker |
[277] | |
IGAC-71 |
IG-L-70 Payload |
Undisclosed |
IG-L-70 linker |
[277] | |
IGAC-73 |
IG-L-48 Payload |
Undisclosed |
IG-L-36 linker |
[277] | |
IGAC-75 |
IG-L-45 Payload |
Undisclosed |
IG-L-45 linker |
[277] | |
IGAC-77 |
IG-L-40 Payload |
Undisclosed |
IG-L-40 linker |
[277] | |
IGAC-79 |
CC-885 |
Undisclosed |
IG-L-42 linker |
[277] | |
IGAC-81 |
IG-L-41 Payload |
Undisclosed |
IG-L-41 linker |
[277] | |
IGAC-84 |
IG-L-43 Payload |
Undisclosed |
IG-L-43 linker |
[277] | |
IGAC-85 |
IG-L-44 Payload |
Undisclosed |
IG-L-44 linker |
[277] | |
IGAC-93 |
IG-L-18 Payload |
Undisclosed |
IG-L-25 linker |
[277] | |
IGAC-96 |
CC-885 |
Undisclosed |
IG-L-73 linker |
[277] | |
IGAC-97 |
Smol006 |
Eukaryotic peptide chain release factor GTP-binding subunit ERF3A (GSPT1) |
IG-L-74 linker |
[277] | |
IGAC-98 |
IG-L-79 Payload |
Undisclosed |
IG-L-75 linker |
[277] | |
IGAC-99 |
IG-L-76 Payload |
Undisclosed |
IG-L-76 linker |
[277] | |
IGAC-100 |
IG-L-79 Payload |
Undisclosed |
IG-L-77 linker |
[277] | |
IGAC-101 |
CC-885 |
Undisclosed |
IG-L-74 linker |
[277] | |
IGAC-102 |
IG-L-79 Payload |
Undisclosed |
IG-L-74 linker |
[277] | |
IGAC-103 |
IG-L-80 Payload |
Undisclosed |
IG-L-74 linker |
[277] | |
IGAC-104 |
IG-L-81 Payload |
Undisclosed |
IG-L-81 linker |
[277] | |
IGAC-105 |
IG-L-82 Payload |
Undisclosed |
IG-L-82 linker |
[277] | |
JP7560255B2 ControlADC45 |
Undisclosed |
Undisclosed |
Undisclosed |
[278] | |
CN113874046B ADC-1 |
Monomethyl auristatin E |
Microtubule (MT) |
CN113874046B-ADC-1-LINKER |
[279] | |
CN113874046B ADC-2 |
CN113874046B-ADC-2-PAYLOAD |
Undisclosed |
CN113874046B-ADC-2-LINKER |
[279] | |
CN113874046B ADC-3 |
CN113874046B-ADC-3-PAYLOAD |
Undisclosed |
CN113874046B-ADC-3-LINKER |
[279] | |
CN113874046B ADC-4 |
Monomethyl auristatin E |
Microtubule (MT) |
CN113874046B-ADC-4-LINKER |
[279] | |
CN113874046B ADC-5 |
CN113874046B-ADC-5-PAYLOAD |
Undisclosed |
CN113874046B-ADC-5-LINKER |
[279] | |
CN113874046B ADC-6 |
CN113874046B-ADC-6-PAYLOAD |
Undisclosed |
CN113874046B-ADC-6-LINKER |
[279] | |
CN113874046B ADC-7 |
Monomethyl auristatin E |
Microtubule (MT) |
CN113874046B-ADC-7-LINKER |
[279] | |
CN113453724B ADC-A |
CN113453724B-ADCA-PAYLOAD |
Undisclosed |
CN113453724B-ADCA-LINKER |
[280] | |
CN119630431A ADC-90 |
CN119630431A-ADC-82-PAYLOAD |
Undisclosed |
CN119630431A-ADC-82-LINKER |
[281] | |
TWI857167B IC-1 |
TWI857167B-IC-1-PAYLOAD |
Undisclosed |
TWI857167B-IC-1-LINKER |
[282] | |
TWI857167B IC-2 2.4 |
TWI857167B-IC-2-PAYLOAD |
Undisclosed |
TWI857167B-IC-1-LINKER |
[282] | |
TWI857167B IC-2 4.2 |
TWI857167B-IC-2-PAYLOAD |
Undisclosed |
TWI857167B-IC-1-LINKER |
[282] | |
TWI857167B IC-3 |
TWI857167B-IC-3-PAYLOAD |
Undisclosed |
Aminobenzazepine-linker Formula II-3 |
[282] | |
TWI857167B IC-6 |
TWI857167B-IC-6-PAYLOAD |
Undisclosed |
Aminobenzazepine-linker Formula II-3 |
[282] | |
TWI857167B IC-7 |
TWI857167B-IC-7-PAYLOAD |
Undisclosed |
Aminobenzazepine-linker Formula II-3 |
[282] | |
TWI857167B IC-10 |
TWI857167B-IC-10-PAYLOAD |
Undisclosed |
TWI857167B-IC-1-LINKER |
[282] | |
TWI857167B IC-11 |
TWI857167B-IC-11-PAYLOAD |
Undisclosed |
Aminobenzazepine-linker Formula II-3 |
[282] | |
TWI857167B IC-13 |
TWI857167B-IC-13-PAYLOAD |
Undisclosed |
Aminobenzazepine-linker Formula II-3 |
[282] | |
TWI857167B IC-14 |
TWI857167B-IC-14-PAYLOAD |
Undisclosed |
Aminobenzazepine-linker Formula II-3 |
[282] | |
TWI857167B IC-15 |
TWI857167B IC-74 payload |
Undisclosed |
Aminobenzazepine-linker Formula II-3 |
[282] | |
TWI857167B IC-16 |
TWI857167B-IC-16-PAYLOAD |
Undisclosed |
Aminobenzazepine-linker Formula II-3 |
[282] | |
TWI857167B IC-17 |
TWI857167B-IC-17-PAYLOAD |
Undisclosed |
Aminobenzazepine-linker Formula II-3 |
[282] | |
TWI857167B IC-18 |
TWI857167B-IC-18-PAYLOAD |
Undisclosed |
Aminobenzazepine-linker Formula II-3 |
[282] | |
TWI857167B IC-19 |
TWI857167B-IC-19-PAYLOAD |
Undisclosed |
Aminobenzazepine-linker Formula II-3 |
[282] | |
TWI857167B IC-20 |
TWI857167B-IC-20-PAYLOAD |
Undisclosed |
Aminobenzazepine-linker Formula II-3 |
[282] | |
TWI857167B IC-21 |
TWI857167B-IC-21-PAYLOAD |
Undisclosed |
Aminobenzazepine-linker Formula II-3 |
[282] | |
TWI857167B IC-22 |
TWI857167B-IC-22-PAYLOAD |
Undisclosed |
Aminobenzazepine-linker Formula II-3 |
[282] | |
TWI857167B IC-23 |
TWI857167B-IC-23-PAYLOAD |
Undisclosed |
Aminobenzazepine-linker Formula II-3 |
[282] | |
TWI857167B IC-24 |
TWI857167B-IC-24-PAYLOAD |
Undisclosed |
Aminobenzazepine-linker Formula II-3 |
[282] | |
TWI857167B IC-25 |
TWI857167B-IC-25-PAYLOAD |
Undisclosed |
Aminobenzazepine-linker Formula II-3 |
[282] | |
TWI857167B IC-26 |
TWI857167B-IC-26-PAYLOAD |
Undisclosed |
Aminobenzazepine-linker Formula II-3 |
[282] | |
TWI857167B IC-27 |
TWI857167B-IC-27-PAYLOAD |
Undisclosed |
Aminobenzazepine-linker Formula II-3 |
[282] | |
TWI857167B IC-28 |
TWI857167B-IC-28-PAYLOAD |
Undisclosed |
Aminobenzazepine-linker Formula II-3 |
[282] | |
TWI857167B IC-29 |
TWI857167B IC-67 payload |
Undisclosed |
TWI857167B-IC-29-LINKER |
[282] | |
TWI857167B IC-30 |
TWI857167B IC-38 payload |
Undisclosed |
TWI857167B-IC-30-LINKER |
[282] | |
TWI857167B IC-31 |
TWI857167B-IC-31-PAYLOAD |
Undisclosed |
Aminobenzazepine-linker Formula II-3 |
[282] | |
TWI857167B IC-32 |
TWI857167B-IC-32-PAYLOAD |
Undisclosed |
TWI857167B-IC-32-LINKER |
[282] | |
TWI857167B IC-34 |
TWI857167B-IC-34-PAYLOAD |
Undisclosed |
Aminobenzazepine-linker Formula II-3 |
[282] | |
TWI857167B IC-35 |
TWI857167B-IC-35-PAYLOAD |
Undisclosed |
TWI857167B-IC-35-LINKER |
[282] | |
TWI857167B IC-36 |
TWI857167B-IC-36-PAYLOAD |
Undisclosed |
Aminobenzazepine-linker Formula II-3 |
[282] | |
TWI857167B IC-37 |
TWI857167B-IC-37-PAYLOAD |
Undisclosed |
Undisclosed |
[282] | |
TWI857167B IC-38 |
TWI857167B IC-38 payload |
Undisclosed |
Aminobenzazepine-linker Formula II-72 |
[282] | |
TWI857167B IC-39 |
TWI857167B-IC-39-PAYLOAD |
Undisclosed |
Undisclosed |
[282] | |
TWI857167B IC-40 |
TWI857167B-IC-39-PAYLOAD |
Undisclosed |
Aminobenzazepine-linker Formula II-72 |
[282] | |
TWI857167B IC-41 |
TWI857167B-IC-41-PAYLOAD |
Undisclosed |
Aminobenzazepine-linker Formula II-72 |
[282] | |
TWI857167B IC-42 |
TWI857167B-IC-42-PAYLOAD |
Undisclosed |
Aminobenzazepine-linker Formula II-72 |
[282] | |
TWI857167B IC-43 |
TWI857167B-IC-43-PAYLOAD |
Undisclosed |
Aminobenzazepine-linker Formula II-72 |
[282] | |
TWI857167B IC-44 |
TWI857167B-IC-44-PAYLOAD |
Undisclosed |
Aminobenzazepine-linker Formula II-3 |
[282] | |
TWI857167B IC-45 |
TWI857167B-IC-45-PAYLOAD |
Undisclosed |
Aminobenzazepine-linker Formula II-72 |
[282] | |
TWI857167B IC-46 |
TWI857167B-IC-45-PAYLOAD |
Undisclosed |
Aminobenzazepine-linker Formula II-72 |
[282] | |
TWI857167B IC-47 |
TWI857167B-IC-47-PAYLOAD |
Undisclosed |
Aminobenzazepine-linker Formula II-72 |
[282] | |
TWI857167B IC-48 |
TWI857167B-IC-48-PAYLOAD |
Undisclosed |
Aminobenzazepine-linker Formula II-3 |
[282] | |
TWI857167B IC-49 |
TWI857167B-IC-49-PAYLOAD |
Undisclosed |
Aminobenzazepine-linker Formula II-3 |
[282] | |
TWI857167B IC-50 |
TWI857167B-IC-50-PAYLOAD |
Undisclosed |
Aminobenzazepine-linker Formula II-3 |
[282] | |
TWI857167B IC-51 |
TWI857167B-IC-51-PAYLOAD |
Undisclosed |
Aminobenzazepine-linker Formula II-3 |
[282] | |
TWI857167B IC-52 |
TWI857167B-IC-52-PAYLOAD |
Undisclosed |
Aminobenzazepine-linker Formula II-72 |
[282] | |
TWI857167B IC-53 |
TWI857167B-IC-53-PAYLOAD |
Undisclosed |
Aminobenzazepine-linker Formula II-72 |
[282] | |
TWI857167B IC-54 |
TWI857167B-IC-54-PAYLOAD |
Undisclosed |
Aminobenzazepine-linker Formula II-72 |
[282] | |
TWI857167B IC-55 |
TWI857167B-IC-55-PAYLOAD |
Undisclosed |
Aminobenzazepine-linker Formula II-72 |
[282] | |
TWI857167B IC-56 |
TWI857167B-IC-56-PAYLOAD |
Undisclosed |
Aminobenzazepine-linker Formula II-72 |
[282] | |
TWI857167B IC-57 |
TWI857167B-IC-55-PAYLOAD |
Undisclosed |
Aminobenzazepine-linker Formula II-3 |
[282] | |
TWI857167B IC-58 |
TWI857167B-IC-58-PAYLOAD |
Undisclosed |
Aminobenzazepine-linker Formula II-3 |
[282] | |
TWI857167B IC-59 |
TWI857167B-IC-59-PAYLOAD |
Undisclosed |
Aminobenzazepine-linker Formula II-72 |
[282] | |
TWI857167B IC-60 |
TWI857167B-IC-60-PAYLOAD |
Undisclosed |
Aminobenzazepine-linker Formula II-72 |
[282] | |
TWI857167B IC-61 |
TWI857167B IC-67 payload |
Undisclosed |
TWI857167B-IC-61-LINKER |
[282] | |
TWI857167B IC-62 |
TWI857167B-IC-62-PAYLOAD |
Undisclosed |
Aminobenzazepine-linker Formula II-72 |
[282] | |
TWI857167B IC-63 |
TWI857167B-IC-63-PAYLOAD |
Undisclosed |
Aminobenzazepine-linker Formula II-72 |
[282] | |
TWI857167B IC-64 |
TWI857167B IC-74 payload |
Undisclosed |
Aminobenzazepine-linker Formula II-72 |
[282] | |
TWI857167B IC-65 |
TWI857167B-IC-65-PAYLOAD |
Undisclosed |
Aminobenzazepine-linker Formula II-3 |
[282] | |
TWI857167B IC-66 |
TWI857167B-IC-65-PAYLOAD |
Undisclosed |
TWI857167B-IC-66-LINKER |
[282] | |
TWI857167B IC-67 |
TWI857167B IC-67 payload |
Undisclosed |
Aminobenzazepine-linker Formula II-72 |
[282] | |
TWI857167B IC-68 |
TWI857167B-IC-67-PAYLOAD |
Undisclosed |
Aminobenzazepine-linker Formula II-3 |
[282] | |
TWI857167B IC-69 |
TWI857167B-IC-68-PAYLOAD |
Undisclosed |
Aminobenzazepine-linker Formula II-3 |
[282] | |
TWI857167B IC-70 |
TWI857167B-IC-69-PAYLOAD |
Undisclosed |
Aminobenzazepine-linker Formula II-3 |
[282] | |
TWI857167B IC-71 |
TWI857167B-IC-70-PAYLOAD |
Undisclosed |
TWI857167B-IC-70-LINKER |
[282] | |
TWI857167B IC-72 |
undisclosed |
Undisclosed |
TWI857167B-IC-71-LINKER |
[282] | |
TWI857167B IC-73 |
TWI857167B-IC-69-PAYLOAD |
Undisclosed |
TWI857167B-IC-72-LINKER |
[282] | |
TWI857167B IC-74 |
TWI857167B IC-74 payload |
Undisclosed |
Aminobenzazepine-linker Formula II-82 |
[282] | |
TWI857167B IC-75 |
TWI857167B-IC-74-PAYLOAD |
Undisclosed |
TWI857167B-IC-70-LINKER |
[282] | |
TWI857167B IC-76 |
TWI857167B-IC-75-PAYLOAD |
Undisclosed |
Aminobenzazepine-linker Formula II-3 |
[282] | |
TWI857167B IC-77 |
TWI857167B-IC-50-PAYLOAD |
Undisclosed |
Aminobenzazepine-linker Formula II-82 |
[282] | |
TWI857167B IC-78 |
TWI857167B-IC-77-PAYLOAD |
Undisclosed |
Aminobenzazepine-linker Formula II-3 |
[282] | |
TWI857167B IC-79 |
TWI857167B-IC-78-PAYLOAD |
Undisclosed |
Aminobenzazepine-linker Formula II-3 |
[282] | |
TWI857167B IC-80 |
TWI857167B-IC-79-PAYLOAD |
Undisclosed |
Aminobenzazepine-linker Formula II-3 |
[282] | |
TWI857167B IC-81 |
TWI857167B-IC-80-PAYLOAD |
Undisclosed |
Aminobenzazepine-linker Formula II-3 |
[282] | |
TWI857167B IC-82 |
TWI857167B-IC-81-PAYLOAD |
Undisclosed |
Aminobenzazepine-linker Formula II-3 |
[282] | |
TWI857167B IC-83 |
TWI857167B IC-84 payload |
Undisclosed |
Aminobenzazepine-linker Formula II-3 |
[282] | |
TWI857167B IC-84 |
TWI857167B IC-84 payload |
Undisclosed |
TWI857167B-IC-82-LINKER |
[282] | |
TWI857167B IC-85 |
TWI857167B-IC-85-PAYLOAD |
Undisclosed |
TWI857167B-IC-82-LINKER |
[282] | |
TWI857167B IC-86 |
TWI857167B-IC-85-PAYLOAD |
Undisclosed |
Aminobenzazepine-linker Formula II-82 |
[282] | |
TWI857167B IC-87 |
TWI857167B-IC-86-PAYLOAD |
Undisclosed |
TWI857167B-IC-85-LINKER |
[282] | |
TWI857167B IC-88 |
TWI857167B-IC-78-PAYLOAD |
Undisclosed |
TWI857167B-IC-82-LINKER |
[282] | |
TWI857167B IC-89 |
TWI857167B-IC-88-PAYLOAD |
Undisclosed |
Undisclosed |
[282] | |
TWI857167B IC-90 |
TWI857167B-IC-88-PAYLOAD |
Undisclosed |
TWI857167B-IC-82-LINKER |
[282] | |
TWI857167B IC-91 |
TWI857167B-IC-90-PAYLOAD |
Undisclosed |
Undisclosed |
[282] | |
TWI857167B IC-92 |
TWI857167B-IC-91-PAYLOAD |
Undisclosed |
TWI857167B-IC-90-LINKER |
[282] | |
TWI857167B IC-93 |
TWI857167B-IC-92-PAYLOAD |
Undisclosed |
TWI857167B-IC-82-LINKER |
[282] | |
TWI857167B IC-94 |
TWI857167B-IC-93-PAYLOAD |
Undisclosed |
TWI857167B-IC-82-LINKER |
[282] | |
TWI857167B IC-95 |
TWI857167B-IC-86-PAYLOAD |
Undisclosed |
Undisclosed |
[282] | |
TWI857167B IC-96 |
TWI857167B-IC-95-PAYLOAD |
Undisclosed |
Undisclosed |
[282] | |
TWI857167B IC-97 |
TWI857167B-IC-96-PAYLOAD |
Undisclosed |
TWI857167B-IC-95-LINKER |
[282] | |
TWI857167B IC-98 |
TWI857167B-IC-63-PAYLOAD |
Undisclosed |
TWI857167B-IC-96-LINKER |
[282] | |
TWI857167B IC-99 |
TWI857167B-IC-98-PAYLOAD |
Undisclosed |
TWI857167B-IC-97-LINKER |
[282] | |
TWI857167B IC-100 |
TWI857167B-IC-99-PAYLOAD |
Undisclosed |
Undisclosed |
[282] | |
TWI857167B IC-101 |
TWI857167B-IC-99-PAYLOAD |
Undisclosed |
Undisclosed |
[282] | |
TWI857167B IC-102 |
TWI857167B-IC-101-PAYLOAD |
Undisclosed |
Undisclosed |
[282] | |
TWI857167B IC-103 |
TWI857167B-IC-102-PAYLOAD |
Undisclosed |
TWI857167B-IC-101-LINKER |
[282] | |
TWI857167B IC-104 |
TWI857167B-IC-95-PAYLOAD |
Undisclosed |
Undisclosed |
[282] | |
TWI857167B IC-105 |
TWI857167B-IC-104-PAYLOAD |
Undisclosed |
Undisclosed |
[282] | |
TWI857167B IC-106 |
TWI857167B-IC-105-PAYLOAD |
Undisclosed |
Undisclosed |
[282] | |
TWI857167B IC-107 |
TWI857167B-IC-106-PAYLOAD |
Undisclosed |
TWI857167B-IC-105-LINKER |
[282] | |
TWI857167B IC-108 |
TWI857167B-IC-107-PAYLOAD |
Undisclosed |
TWI857167B-IC-95-LINKER |
[282] | |
TWI857167B IC-109 |
TWI857167B-IC-108-PAYLOAD |
Undisclosed |
Undisclosed |
[282] | |
TWI857167B IC-110 |
TWI857167B-IC-101-PAYLOAD |
Undisclosed |
TWI857167B-IC-108-LINKER |
[282] | |
TWI857167B IC-111 |
TWI857167B-IC-110-PAYLOAD |
Undisclosed |
Undisclosed |
[282] | |
TWI857167B IC-112 |
TWI857167B-IC-111-PAYLOAD |
Undisclosed |
Undisclosed |
[282] | |
TWI857167B IC-113 |
TWI857167B-IC-111-PAYLOAD |
Undisclosed |
Undisclosed |
[282] | |
TWI857167B IC-114 |
TWI857167B-IC-113-PAYLOAD |
Undisclosed |
Undisclosed |
[282] | |
TWI857167B IC-115 |
undisclosed |
Undisclosed |
Undisclosed |
[282] | |
TWI857167B IC-116 |
TWI857167B-IC-115-PAYLOAD |
Undisclosed |
Undisclosed |
[282] | |
TWI857167B IC-117 |
TWI857167B-IC-116-PAYLOAD |
Undisclosed |
Undisclosed |
[282] | |
TWI857167B IC-118 |
TWI857167B-IC-117-PAYLOAD |
Undisclosed |
Undisclosed |
[282] | |
TWI857167B IC-119 |
TWI857167B-IC-118-PAYLOAD |
Undisclosed |
Undisclosed |
[282] | |
TWI857167B IC-120 |
undisclosed |
Undisclosed |
Undisclosed |
[282] | |
TWI857167B IC-121 |
TWI857167B-IC-115-PAYLOAD |
Undisclosed |
Undisclosed |
[282] | |
TWI857167B IC-122 |
undisclosed |
Undisclosed |
Undisclosed |
[282] | |
TWI857167B IC-123 |
undisclosed |
Undisclosed |
Undisclosed |
[282] | |
EP4487874A1-2 |
EP4487874A1-2payload |
Undisclosed |
RU20241285-1-linker |
[71] | |
EP4487874A1-3 |
undisclosed |
Undisclosed |
EP4487874A1-3linker |
[71] | |
EP4487874A1-5 |
EP4487874A1-5payload |
Undisclosed |
RU20241285-4-linker |
[71] | |
EP4487874A1-6 |
EP4487874A1-6payload |
Undisclosed |
RU20241285-4-linker |
[71] | |
EP4487874A1-7 |
EP4487874A1-7payload |
Undisclosed |
EP4487874A1-7linker |
[71] | |
EP4487874A1-8 |
EP4487874A1-8payload |
Undisclosed |
EP4487874A1-8linker |
[71] | |
EP4487874A1-9 |
EP4487874A1-9payload |
Undisclosed |
EP4487874A1-9linker |
[71] | |
EP4487874A1-10 |
EP4487874A1-10payload |
Undisclosed |
EP4487874A1-10linker |
[71] | |
EP4487874A1-11 |
EP4487874A1-11payload |
Undisclosed |
RU20241285-9-linker |
[71] | |
EP4487874A1-12 |
DX-8951 derivative (DXd) |
DNA topoisomerase 1 (TOP1) |
EP4487874A1-12linker |
[71] | |
EP4487874A1-13 |
EP4487874A1-13payload |
Undisclosed |
EP4487874A1-13linker |
[71] | |
EP4487874A1-14 |
DX-8951 derivative (DXd) |
DNA topoisomerase 1 (TOP1) |
EP4487874A1-14linker |
[71] | |
EP4487874A1-15 |
EP4487874A1-15payload |
Undisclosed |
EP4487874A1-15linker |
[71] | |
EP4487874A1-16 |
EP4487874A1-16payload |
Undisclosed |
EP4487874A1-10linker |
[71] | |
EP4487874A1-17 |
EP4487874A1-17payload |
Undisclosed |
EP4487874A1-17linker |
[71] | |
EP4487874A1-18 |
Topo1 inhibitor A |
DNA topoisomerase I (TOP1) |
EP4487874A1-18linker |
[71] | |
EP4487874A1-19 |
RU20241285-23-payload |
DNA topoisomerase I (TOP1) |
EP4487874A1-19linker |
[71] | |
EP4487874A1-20 |
undisclosed |
Undisclosed |
EP4487874A1-20linker |
[71] | |
EP4487874A1-21 |
RU20241285-23-payload |
DNA topoisomerase I (TOP1) |
RU20241285-19-linker |
[71] | |
EP4487874A1-22 |
Topo1 inhibitor A |
DNA topoisomerase I (TOP1) |
EP4487874A1-22linker |
[71] | |
EP4487874A1-23 |
EP4487874A1-16payload |
Undisclosed |
EP4487874A1-23linker |
[71] | |
EP4487874A1-24 |
EP4487874A1-16payload |
Undisclosed |
EP4487874A1-24linker |
[71] | |
EP4487874A1-25 |
RU20241285-23-payload |
DNA topoisomerase I (TOP1) |
EP4487874A1-23linker |
[71] | |
EP4487874A1-26 |
RU20241285-23-payload |
DNA topoisomerase I (TOP1) |
EP4487874A1-24linker |
[71] | |
38354417 T-DL1 |
FD1 |
DNA topoisomerase I (TOP1) |
MT-GGFG-AM |
[283] | |
38354417 T-DL3 |
FD2 |
DNA topoisomerase I (TOP1) |
MT-GGFG-AM |
[283] | |
38354417 T-DL4 |
FD3 |
DNA topoisomerase I (TOP1) |
MT-GGFG-AM |
[283] | |
38354417 T-DL9 |
10NH2-11F-Camptothecin |
DNA topoisomerase I (TOP1) |
MT-GGFG-AM |
[283] | |
38354417 T-DL5 |
FD5 |
DNA topoisomerase I (TOP1) |
MT-GGFG-AM |
[283] | |
38354417 T-DL6 |
FD5 |
DNA topoisomerase I (TOP1) |
Mc-Gly-Gly-Phe-Gly |
[283] | |
38354417 T-DL11 |
FD5 |
DNA topoisomerase I (TOP1) |
MT-GGFG-AM |
[283] | |
38354417 T-DL13 |
FD6 |
DNA topoisomerase I (TOP1) |
MT-GGFG-AM |
[283] | |
38354417 T-DL14 |
FD7 |
DNA topoisomerase I (TOP1) |
MT-GGFG-AM |
[283] | |
38354417 T-DL7 |
DX-8951 derivative (DXd) |
DNA topoisomerase 1 (TOP1) |
MT-GGFG-AM |
[283] | |
AZO-ADC-0 |
Monomethyl auristatin E |
Microtubule (MT) |
Solubilizing group-PEG0-Hypoxia sensitive linker-Azobenzene |
[284] | |
AZO-ADC-2 |
Monomethyl auristatin E |
Microtubule (MT) |
Solubilizing group-PEG2-Hypoxia sensitive linker-Azobenzene |
[284] | |
AZO-ADC-4 |
Monomethyl auristatin E |
Microtubule (MT) |
Solubilizing group-PEG4-Hypoxia sensitive linker-Azobenzene |
[284] | |
AZO-ADC-6 |
Monomethyl auristatin E |
Microtubule (MT) |
Solubilizing group-PEG6-Hypoxia sensitive linker-Azobenzene |
[284] | |
AZO-ADC-8 |
Monomethyl auristatin E |
Microtubule (MT) |
Solubilizing group-PEG8-Hypoxia sensitive linker-Azobenzene |
[284] | |
IgG (8)-m- (b-PEG12)-VC-MMAE |
Monomethyl auristatin E |
Microtubule (MT) |
IgG (8)-m- (b-PEG12)-VC-MMAE |
[79] | |
WO2024169913A1 ADC01-01-8 |
Smol006 |
Eukaryotic peptide chain release factor GTP-binding subunit ERF3A (GSPT1) |
Mc-Val-Cit-PABC |
[86] | |
WO2024169913A1 ADC01-01-4 |
B19 |
Eukaryotic peptide chain release factor GTP-binding subunit ERF3A (GSPT1) |
Mc-Val-Cit-PABC |
[86] | |
WO2024169913A1 ADC01-02-8 |
B19 |
Eukaryotic peptide chain release factor GTP-binding subunit ERF3A (GSPT1) |
Mc-Val-Cit-PABC |
[86] | |
WO2024169913A1 ADC01-02-4 |
B19 |
Eukaryotic peptide chain release factor GTP-binding subunit ERF3A (GSPT1) |
Mc-Val-Ala-PABC |
[86] | |
WO2024169913A1 ADC01-06-8 |
B19 |
Eukaryotic peptide chain release factor GTP-binding subunit ERF3A (GSPT1) |
Mc-Val-Ala-PABC |
[86] | |
WO2024169913A1 ADC01-06-4 |
B63 |
Eukaryotic peptide chain release factor GTP-binding subunit ERF3A (GSPT1) |
Mc-Val-Ala-PABC |
[86] | |
WO2024169913A1 ADC01-07-4 |
B63 |
Eukaryotic peptide chain release factor GTP-binding subunit ERF3A (GSPT1) |
Mc-Val-Ala-PABC |
[86] | |
WO2024169913A1 ADC01-08-8 |
B19 |
Eukaryotic peptide chain release factor GTP-binding subunit ERF3A (GSPT1) |
(Linker-02)MC-PEG-VA-PAB |
[86] | |
WO2024169913A1 ADC01-08-4 |
B19 |
Eukaryotic peptide chain release factor GTP-binding subunit ERF3A (GSPT1) |
(Linker-03)SMCC-TAZ-PEG-VC-PAB |
[86] | |
WO2024222841A1 ADC38 |
(S)B19 |
Eukaryotic peptide chain release factor GTP-binding subunit ERF3A (GSPT1) |
OXDc-VA-PAB (PEG) |
[285] | |
WO2024222841A1 ADC38-4 |
(S)B19 |
Eukaryotic peptide chain release factor GTP-binding subunit ERF3A (GSPT1) |
OXDc-VA-PAB (PEG) |
[285] | |
WO2024222841A1 ADC39 |
(S)B19 |
Eukaryotic peptide chain release factor GTP-binding subunit ERF3A (GSPT1) |
OXD-VA-PAB (PEG) |
[285] | |
WO2024222841A1 ADC40 |
(S)B19 |
Eukaryotic peptide chain release factor GTP-binding subunit ERF3A (GSPT1) |
OXDc-VA-PAB (Glu) |
[285] | |
WO2024222841A1 ADC41 |
(S)B19 |
Eukaryotic peptide chain release factor GTP-binding subunit ERF3A (GSPT1) |
OXD-VA-PAB (Glu) |
[285] | |
WO2024222841A1 ADC42 |
B19 |
Eukaryotic peptide chain release factor GTP-binding subunit ERF3A (GSPT1) |
OXDc-VA-PAB (PEG) |
[285] | |
WO2024222841A1 ADC43 |
(R)B19 |
Eukaryotic peptide chain release factor GTP-binding subunit ERF3A (GSPT1) |
OXDc-VA-PAB (PEG) |
[285] | |
WO2024222841A1 ADC44 |
B61 |
Eukaryotic peptide chain release factor GTP-binding subunit ERF3A (GSPT1) |
OXDc-VA-PAB (PEG) |
[285] | |
WO2024222841A1 ADC45 |
B63 |
Eukaryotic peptide chain release factor GTP-binding subunit ERF3A (GSPT1) |
OXDc-VA-PAB (PEG) |
[285] | |
T-ADC-2 |
(S)B19 |
Eukaryotic peptide chain release factor GTP-binding subunit ERF3A (GSPT1) |
OXDc-VA-PAB (PEG) |
[285] | |
T-ADC |
(S)B19 |
Eukaryotic peptide chain release factor GTP-binding subunit ERF3A (GSPT1) |
OXDc-VA-PAB (PEG) |
[285] | |
WO2024222841A1 ADC39-4 |
(S)B19 |
Eukaryotic peptide chain release factor GTP-binding subunit ERF3A (GSPT1) |
OXD-VA-PAB (PEG) |
[285] | |
WO2024222841A1 ADC40-4 |
(S)B19 |
Eukaryotic peptide chain release factor GTP-binding subunit ERF3A (GSPT1) |
OXDc-VA-PAB (Glu) |
[285] | |
WO2024222841A1 ADC41-4 |
(S)B19 |
Eukaryotic peptide chain release factor GTP-binding subunit ERF3A (GSPT1) |
OXD-VA-PAB (Glu) |
[285] | |
WO2024222841A1 ADC42-4 |
B19 |
Eukaryotic peptide chain release factor GTP-binding subunit ERF3A (GSPT1) |
OXDc-VA-PAB (PEG) |
[285] | |
WO2024222841A1 ADC43-4 |
(R)B19 |
Eukaryotic peptide chain release factor GTP-binding subunit ERF3A (GSPT1) |
OXDc-VA-PAB (PEG) |
[285] | |
WO2024222841A1 ADC44-4 |
B61 |
Eukaryotic peptide chain release factor GTP-binding subunit ERF3A (GSPT1) |
OXDc-VA-PAB (PEG) |
[285] | |
CN119343374A ADC-S108 |
Undisclosed |
Undisclosed |
Undisclosed |
[90] | |
CN119343374A ADC-S105 |
Undisclosed |
Undisclosed |
Undisclosed |
[90] |
trastuzumab
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
WO2024230301A1 ADC-1 |
Undisclosed |
Undisclosed |
Undisclosed |
[232] | |
WO2024230301A1 ADC-2 |
Undisclosed |
Undisclosed |
Undisclosed |
[232] | |
WO2024230301A1 ADC-3 |
Undisclosed |
Undisclosed |
Undisclosed |
[232] | |
WO2024230301A1 ADC-4 |
Undisclosed |
Undisclosed |
Undisclosed |
[232] | |
WO2024230301A1 ADC-5 |
Undisclosed |
Undisclosed |
Undisclosed |
[232] | |
WO2024230301A1 ADC-6 |
Undisclosed |
Undisclosed |
Undisclosed |
[232] | |
WO2024230301A1 ADC-7 |
Undisclosed |
Undisclosed |
Undisclosed |
[232] | |
WO2024230301A1 ADC-8 |
Undisclosed |
Undisclosed |
Undisclosed |
[232] | |
WO2024230301A1 ADC-9 |
Undisclosed |
Undisclosed |
Undisclosed |
[232] | |
WO2024230301A1 ADC-10 |
Undisclosed |
Undisclosed |
Undisclosed |
[232] | |
WO2024230301A1 ADC-11 |
Undisclosed |
Undisclosed |
Undisclosed |
[232] | |
WO2024230301A1 ADC-12 |
Undisclosed |
Undisclosed |
Undisclosed |
[232] | |
WO2024230301A1 ADC-13 |
Undisclosed |
Undisclosed |
Undisclosed |
[232] | |
WO2024230301A1 ADC-14 |
Undisclosed |
Undisclosed |
Undisclosed |
[232] | |
WO2024230301A1 ADC-15 |
Undisclosed |
Undisclosed |
Undisclosed |
[232] | |
WO2024230301A1 ADC-16 |
Undisclosed |
Undisclosed |
Undisclosed |
[232] | |
WO2024230301A1 ADC-17 |
Undisclosed |
Undisclosed |
Undisclosed |
[232] | |
WO2024230301A1 ADC-18 |
Undisclosed |
Undisclosed |
Undisclosed |
[232] | |
WO2024230301A1 ADC-19 |
Undisclosed |
Undisclosed |
Undisclosed |
[232] | |
WO2024230301A1 ADC-20 |
Undisclosed |
Undisclosed |
Undisclosed |
[232] | |
WO2024230301A1 ADC1a-DAR4 |
Undisclosed |
Undisclosed |
Undisclosed |
[232] | |
CN116782954A ADC2-DAR4 |
Undisclosed |
Undisclosed |
Undisclosed |
[233] | |
CN116782954A ADC3-DAR4 |
Undisclosed |
Undisclosed |
Undisclosed |
[233] | |
CN116782954A ADC4a-DAR4 |
Undisclosed |
Undisclosed |
Undisclosed |
[233] | |
CN116782954A ADC4b-DAR4 |
Undisclosed |
Undisclosed |
Undisclosed |
[233] | |
CN116782954A ADC5-DAR2 |
Undisclosed |
Undisclosed |
Undisclosed |
[233] | |
Trastuzumab-ZY-889 |
Undisclosed |
Undisclosed |
Undisclosed |
[234] | |
Trastuzumab-ZY-948 |
Undisclosed |
Undisclosed |
Undisclosed |
[234] | |
Trastuzumab-ZY-894 |
Undisclosed |
Undisclosed |
Undisclosed |
[234] | |
EP4090377A1 EP4090377A1 221 |
Undisclosed |
Undisclosed |
Undisclosed |
[41] | |
Trast-v8-XL06 |
Undisclosed |
Undisclosed |
Undisclosed |
[41] | |
Trast-v4- (201)2 |
Undisclosed |
Undisclosed |
Undisclosed |
[41] | |
US20240245795A1 Antibody Conjugate 1 |
Exatecan |
DNA topoisomerase 1 (TOP1) |
Mc-Val-Cit-PABC |
[244] | |
US20240245795A1 Antibody Conjugate 2 |
Undisclosed |
Undisclosed |
Undisclosed |
[244] | |
US20240245795A1 Antibody Conjugate 3 |
Undisclosed |
Undisclosed |
Undisclosed |
[244] | |
US20240245795A1 Antibody Conjugate 4 |
Undisclosed |
Undisclosed |
Undisclosed |
[244] | |
US20240245795A1 Antibody Conjugate 5 |
Exatecan |
DNA topoisomerase 1 (TOP1) |
Undisclosed |
[244] | |
US20240245795A1 Antibody Conjugate 6 |
Exatecan |
DNA topoisomerase 1 (TOP1) |
Undisclosed |
[244] | |
US20240245795A1 Antibody Conjugate 7 |
Antibody Conjugate 7 +Payload |
DNA topoisomerase I (TOP1) |
Undisclosed |
[244] | |
US20240245795A1 Antibody Conjugate 8 |
Undisclosed |
Undisclosed |
Undisclosed |
[244] | |
US20240245795A1 Antibody Conjugate 11 |
Undisclosed |
Undisclosed |
Undisclosed |
[244] | |
US20240245795A1 Antibody Conjugate 12 |
Undisclosed |
Undisclosed |
Undisclosed |
[244] | |
Trastuzumab-DXD (CN114569739A) |
Undisclosed |
Undisclosed |
Undisclosed |
[256] | |
CN114569739A ADC-1 (trastuzumab) |
Undisclosed |
Undisclosed |
Undisclosed |
[256] | |
CN114569739A ADC-2 (trastuzumab) |
Undisclosed |
Undisclosed |
Undisclosed |
[256] | |
CN114569739A ADC-3 (trastuzumab) |
Undisclosed |
Undisclosed |
Undisclosed |
[256] | |
CN114569739A ADC-4 (trastuzumab) |
Undisclosed |
Undisclosed |
Undisclosed |
[256] | |
CN114569739A ADC-7 (trastuzumab) |
Undisclosed |
Undisclosed |
Undisclosed |
[256] |
trastuzumab (6-N3-GalNAc)2
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
EP4090377A1 EP4090377A1 210 |
Undisclosed |
Undisclosed |
Undisclosed |
[41] |
Trastuzumab (C2)
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
Tras (C2)-Cp |
Cryptophycin-uD[Dap (Me)] |
Undisclosed |
Mc-Val-Cit-PABC |
[286] |
Trastuzumab (C4)
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
Tras (C4)-Cp |
Cryptophycin-uD[Dap (Me)] |
Undisclosed |
Mc-Val-Cit-PABC |
[286] |
Trastuzumab (C8)
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
Tras (C8)-Cp |
Cryptophycin-uD[Dap (Me)] |
Undisclosed |
Mc-Val-Cit-PABC |
[286] | |
Tras (C8)-MMAE |
Monomethyl auristatin E |
Microtubule (MT) |
Mc-Val-Cit-PABC |
[286] |
Trastuzumab (Positively Charged)
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
Positively Charged ADC |
Monomethyl auristatin E |
Microtubule (MT) |
Mc-Val-Cit-PABC |
[216] |
Trastuzumab A114C
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
Neolymphostin ADC 21 |
Neolymphostin A |
3-Phosphoinositide-dependent protein kinase 1 (PDPK1) |
Mc-Val-Cit-PABC-DMEA |
[287] | |
Neolymphostin ADC 22 |
Neolymphostin A |
3-Phosphoinositide-dependent protein kinase 1 (PDPK1) |
PEG4-DMEA |
[287] | |
Neolymphostin ADC 23 |
Neolymphostin A |
3-Phosphoinositide-dependent protein kinase 1 (PDPK1) |
Mc-Val-Cit-PABC |
[287] | |
Neolymphostin ADC 24 |
Neolymphostin A |
3-Phosphoinositide-dependent protein kinase 1 (PDPK1) |
N-Methoxycarbonylmaleimide |
[287] |
Trastuzumab D265C
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
T-D265C-CN-Pro-amanitin |
CN-Pro-dideoxy-alpha-amanitin |
DNA-directed RNA polymerase II subunit RPB2 (POLR2B); DNA-directed RNA polymerase III subunit RPC7 (POLR3G) |
Mal-Val-Ala-PAB |
[288] | |
T-D265C-NH2-Pro-amanitin |
NH2-Pro-dideoxy-alpha-amanitin |
DNA-directed RNA polymerase II subunit RPB2 (POLR2B); DNA-directed RNA polymerase III subunit RPC7 (POLR3G) |
Mc-Val-Ala-PABC |
[288] | |
T-D265C-OH-Pro-amanitin |
OH-Pro-dideoxy-alpha-amanitin |
DNA-directed RNA polymerase II subunit RPB2 (POLR2B); DNA-directed RNA polymerase III subunit RPC7 (POLR3G) |
Mc-Val-Ala-PABC |
[288] |
trastuzumab GalNProSSMe trast-v5a
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
Trast-v5b-XL02 |
Undisclosed |
Undisclosed |
Undisclosed |
[41] |
Trastuzumab I253Q
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
Trastuzumab I253Q-MMAE |
Monomethyl auristatin E |
Microtubule (MT) |
Dansylcadaverine-BCN based linker |
[289] | |
Trastuzumab deglycosylated WT-MMAE |
Monomethyl auristatin E |
Microtubule (MT) |
Dansylcadaverine deglycosylated-BCN based linker |
[289] |
Trastuzumab N297A
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
ADC MMAE/F 4+2 |
Monomethyl auristatin E+Monomethyl auristatin F |
Microtubule (MT) |
DBCO-PEG3-Glu-Val-Cit-PABC; TCO-PEG3-Glu-Val-Cit-PABC |
[290] | |
ADC MMAE/F 2+4 |
Monomethyl auristatin E+Monomethyl auristatin F |
Microtubule (MT) |
DBCO-PEG3-Glu-Val-Cit-PABC; TCO-PEG3-Glu-Val-Cit-PABC |
[290] | |
ADC MMAE/F 2+2 |
Monomethyl auristatin E+Monomethyl auristatin F |
Microtubule (MT) |
DBCO-PEG3-Glu-Val-Cit-PABC; TCO-PEG3-Glu-Val-Cit-PABC |
[290] |
trastuzumab S239C mutant trast-v6
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
Trast-v6-XL02 |
Undisclosed |
Undisclosed |
Undisclosed |
[41] | |
Trast-v6-XL03 |
Undisclosed |
Undisclosed |
C-lock-azide linker |
[41] | |
Trast-v6- (XL05)2 |
Undisclosed |
Undisclosed |
Maleimide linker |
[41] |
Trastuzumab scFv
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
scFv (Herceptin)-PE |
Pseudomonas exotoxin PE38 |
Eukaryotic elongation factor 2 kinase (EEF2K) |
Undisclosed |
[291] | |
scFv(Herceptin)-PE-STXA |
PE15-Stx 2a |
Eukaryotic elongation factor 2 kinase (EEF2K) |
Undisclosed |
[291] | |
ScFv(trastuzumab)-PE38KDEL |
Pseudomonas exotoxin PE38 |
Eukaryotic elongation factor 2 kinase (EEF2K) |
Undisclosed |
[19] |
trastuzumab trast-v1a
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
TCO-trastuzumab trast-v1a-XL11 |
Undisclosed |
Undisclosed |
Undisclosed |
[41] |
trastuzumab trast-v7
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
Trast-v7-XL01 |
Undisclosed |
Undisclosed |
Undisclosed |
[41] |
trastuzumab- (azide)2
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
EP4090377A1 EP4090377A1 211 |
Undisclosed |
Undisclosed |
linker105 |
[41] | |
EP4090377A1 EP4090377A1 212 |
Undisclosed |
Undisclosed |
Undisclosed |
[41] | |
EP4090377A1 EP4090377A1 213 |
Undisclosed |
Undisclosed |
Undisclosed |
[41] | |
EP4090377A1 EP4090377A1 214 |
Undisclosed |
Undisclosed |
Undisclosed |
[41] | |
EP4090377A1 EP4090377A1 215 |
Undisclosed |
Undisclosed |
Undisclosed |
[41] | |
EP4090377A1 EP4090377A1 216 |
Undisclosed |
Undisclosed |
Undisclosed |
[41] | |
EP4090377A1 EP4090377A1 217 |
Undisclosed |
Undisclosed |
linker145 |
[41] |
Trastuzumab-A111
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
AU2022395626A1 ADC-L2-P2 |
Monomethyl auristatin E |
Microtubule (MT) |
H-Tet-Glucuronide |
[292] |
Trastuzumab-A121
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
AU2022395626A1 ADC-H8-P3 |
Undisclosed |
Undisclosed |
Undisclosed |
[292] |
Trastuzumab-A51
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
AU2022395626A1 ADC-L1-P2 |
Monomethyl auristatin E |
Microtubule (MT) |
H-Tet-Glucuronide |
[292] |
Trastuzumab-AL1
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
IgG1 (trastuzumab)-AL1-MMAE |
Monomethyl auristatin E |
Microtubule (MT) |
Undisclosed |
[19] |
Trastuzumab-BUPY
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
Trastuzumab-BUPY-DM1 |
Mertansine DM1 |
Microtubule (MT) |
N3-SMCC |
[293] | |
Trastuzumab-BUPY-TAMRA |
TAMRA |
Undisclosed |
N3-PEG3 |
[293] |
Trastuzumab-CpHK
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
T-CpHK-Tet-ADC |
Monomethyl auristatin E |
Microtubule (MT) |
Tetrazine-PEG5-Val-Ala-PABC |
[294] | |
T-CpHK-Mal-ADC |
Monomethyl auristatin E |
Microtubule (MT) |
Mc-Val-Cit-PABC |
[294] |
Trastuzumab-Fab-cd38
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
38501590 Anti-HER2 ARC-FDC (1) |
Monomethyl auristatin F |
Microtubule (MT) |
2'-Cl-araNAD linker |
[295] | |
38501590 Anti-HER2 ARC-FDC (2) |
Monomethyl auristatin F |
Microtubule (MT) |
2'-Cl-araNAD linker |
[295] |
Trastuzumab-Flexmab
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
Trastuzumab-Flexmab-SG3710 |
SG3199 |
Human Deoxyribonucleic acid (hDNA) |
Mal-PEG8-Val-Ala-PABC |
[108] |
Trastuzumab-G41
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
AU2022395626A1 ADC-L4-P2 |
Monomethyl auristatin E |
Microtubule (MT) |
H-Tet-Glucuronide |
[292] |
Trastuzumab-G42
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
AU2022395626A1 ADC-H7-P2 |
Monomethyl auristatin E |
Microtubule (MT) |
H-Tet-Glucuronide |
[292] |
trastuzumab-GalNProSSMe trast-v5a
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
Trast-v5b-XL01 |
Undisclosed |
Undisclosed |
Undisclosed |
[41] | |
Trast-v5b- (XL05)2 2 |
Undisclosed |
Undisclosed |
Undisclosed |
[41] |
Trastuzumab-H16-K222R-Hg1
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
US11365263B2 ADC#2 |
US11365263B2 ADC#2 payload |
Undisclosed |
US11365263B2 ADC#3 linker |
[296] | |
US11365263B2 ADC#3 |
US11365263B2 ADC#3 payload |
Undisclosed |
US11365263B2 ADC#3 linker |
[296] |
Trastuzumab-K169
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
AU2022395626A1 ADC-L3-P2 |
Monomethyl auristatin E |
Microtubule (MT) |
H-Tet-Glucuronide |
[292] |
Trastuzumab-K249
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
AU2022395626A1 ADC-H1-P1 |
Monomethyl auristatin E |
Microtubule (MT) |
H-Tet-PEG9-Val-Ala-PAB |
[292] | |
AU2022395626A1 ADC-H1-P2 |
Monomethyl auristatin E |
Microtubule (MT) |
H-Tet-Glucuronide |
[292] | |
GlyADC-H1-P2 |
Monomethyl auristatin E |
Microtubule (MT) |
H-Tet-Glucuronide |
[292] |
Trastuzumab-K249&G41
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
AU2022395626A1 ADC-H1L4-P2 |
Monomethyl auristatin E |
Microtubule (MT) |
H-Tet-Glucuronide |
[292] |
Trastuzumab-K249&K169
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
AU2022395626A1 ADC-H1L3-P2 |
Monomethyl auristatin E |
Microtubule (MT) |
H-Tet-Glucuronide |
[292] |
Trastuzumab-K249&K320
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
AU2022395626A1 ADC-H1H4-P2 |
Monomethyl auristatin E |
Microtubule (MT) |
H-Tet-Glucuronide |
[292] |
Trastuzumab-K249&K343
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
AU2022395626A1 ADC-H1H5-P2 |
Monomethyl auristatin E |
Microtubule (MT) |
H-Tet-Glucuronide |
[292] |
Trastuzumab-K251
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
AU2022395626A1 ADC-H2-P1 |
Monomethyl auristatin E |
Microtubule (MT) |
H-Tet-PEG9-Val-Ala-PAB |
[292] |
Trastuzumab-K291
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
AU2022395626A1 ADC-H3-P1 |
Monomethyl auristatin E |
Microtubule (MT) |
H-Tet-PEG9-Val-Ala-PAB |
[292] |
Trastuzumab-K320
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
AU2022395626A1 ADC-H4-P1 |
Monomethyl auristatin E |
Microtubule (MT) |
H-Tet-PEG9-Val-Ala-PAB |
[292] | |
AU2022395626A1 ADC-H4-P2 |
Monomethyl auristatin E |
Microtubule (MT) |
H-Tet-Glucuronide |
[292] | |
GlyADC-H4-P2 |
Monomethyl auristatin E |
Microtubule (MT) |
H-Tet-Glucuronide |
[292] |
Trastuzumab-K320&G41
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
AU2022395626A1 ADC-H4L4-P2 |
Monomethyl auristatin E |
Microtubule (MT) |
H-Tet-Glucuronide |
[292] |
Trastuzumab-K320&K169
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
AU2022395626A1 ADC-H4L3-P2 |
Monomethyl auristatin E |
Microtubule (MT) |
H-Tet-Glucuronide |
[292] |
Trastuzumab-K343
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
AU2022395626A1 ADC-H5-P1 |
Monomethyl auristatin E |
Microtubule (MT) |
H-Tet-PEG9-Val-Ala-PAB |
[292] |
Trastuzumab-P41
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
AU2022395626A1 ADC-H6-P2 |
Monomethyl auristatin E |
Microtubule (MT) |
H-Tet-Glucuronide |
[292] |
Trastuzumab-P41&G41
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
AU2022395626A1 ADC-H6L4-P2 |
Monomethyl auristatin E |
Microtubule (MT) |
H-Tet-Glucuronide |
[292] |
Trastuzumab-P59
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
AU2022395626A1 ADC-L5-P2 |
Monomethyl auristatin E |
Microtubule (MT) |
H-Tet-Glucuronide |
[292] |
Trastuzumab-Qtag2
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
Trastuzumab-Qtag2-Alexa 488-cadaverine |
Alexa 488-cadaverine |
Undisclosed |
Undisclosed |
[297] | |
Trastuzumab-Qtag2-MMAE |
Monomethyl auristatin E |
Microtubule (MT) |
PEG4-VC-PAB |
[297] | |
Trastuzumab-Qtag2-DM1 |
Mertansine DM1 |
Microtubule (MT) |
PEG4-SMCC |
[297] | |
37341172 13d |
NAMPT inhibitor 1b |
Undisclosed |
Undisclosed |
[298] | |
37341172 13f |
NAMPT inhibitor 1b |
Undisclosed |
Undisclosed |
[298] |
trastuzumab-S239C mutant trast-v6
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
Trast-v6-XL01 |
Undisclosed |
Undisclosed |
Undisclosed |
[41] | |
Trast-v6-XL12 |
Undisclosed |
Undisclosed |
Undisclosed |
[41] |
Trastuzumabk453del-Qtag2
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
Trastuzumabk453del-Qtag2-MMAE |
Monomethyl auristatin E |
Microtubule (MT) |
PEG4-VC-PAB |
[297] |
Tratuzumab (P41C)
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
KR1020250011922A ADC-TRA41C |
Undisclosed |
Undisclosed |
Undisclosed |
[299] | |
KR1020250011922A ADC-S105 masked |
Undisclosed |
Undisclosed |
Undisclosed |
[299] | |
KR1020250011922A ADC-S105 demasked |
Undisclosed |
Undisclosed |
Undisclosed |
[299] | |
KR1020250011922A ADC-S105 |
Undisclosed |
Undisclosed |
Undisclosed |
[299] | |
KR1020250011922A ADC-S108 |
Undisclosed |
Undisclosed |
Undisclosed |
[299] | |
KR1020250011922A ADC-S109 |
Undisclosed |
Undisclosed |
Undisclosed |
[299] | |
KR1020250011922A ADC-S110 |
Undisclosed |
Undisclosed |
Undisclosed |
[299] | |
KR1020250011922A ADC-S111 |
Undisclosed |
Undisclosed |
Undisclosed |
[299] | |
KR1020250011922A ADC-TRA41C MMP2-treated |
Undisclosed |
Undisclosed |
Undisclosed |
[299] | |
KR1020250011922A ADC-S423 masked |
Undisclosed |
Undisclosed |
Undisclosed |
[299] | |
KR1020250011922A ADC-S423 demasked |
Undisclosed |
Undisclosed |
Undisclosed |
[299] | |
KR1020250011922A ADC-S426 masked |
Undisclosed |
Undisclosed |
Undisclosed |
[299] | |
KR1020250011922A ADC-S426 MMP2-treated |
Undisclosed |
Undisclosed |
Undisclosed |
[299] | |
KR1020250011922A ADC-S424 masked |
Undisclosed |
Undisclosed |
Undisclosed |
[299] | |
KR1020250011922A ADC-S424 demasked |
Undisclosed |
Undisclosed |
Undisclosed |
[299] | |
KR1020250011922A ADC-S425 masked |
Undisclosed |
Undisclosed |
Undisclosed |
[299] | |
KR1020250011922A ADC-S425 demasked |
Undisclosed |
Undisclosed |
Undisclosed |
[299] | |
KR1020250011922A ADC-S424 MMP2 treated |
Undisclosed |
Undisclosed |
Undisclosed |
[299] | |
KR1020250011922A ADC-S425 MMP2 treated |
Undisclosed |
Undisclosed |
Undisclosed |
[299] |
Trz-HC:p67
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
Trz-HC:p67-MMAE |
Monomethyl auristatin E |
Microtubule (MT) |
Undisclosed |
[300] |
Trz-LC:p67
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
Trz-LC:p67-MMAE |
Monomethyl auristatin E |
Microtubule (MT) |
Undisclosed |
[300] |
WO2015095301A2 ADC-1 antibody
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
WO2015095301A2 ADC-1 |
WO2015095301A2 ADC-1 payload |
Undisclosed |
WO2015095301A2 ADC-1 linker |
[12] |
WO2015095301A2 ADC-10 antibody
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
WO2015095301A2 ADC-10 |
WO2015095301A2 ADC-10 payload |
Undisclosed |
WO2015095301A2 ADC-10 linker |
[12] |
WO2015095301A2 ADC-11 antibody
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
WO2015095301A2 ADC-11 |
WO2015095301A2 ADC-11 payload |
Undisclosed |
WO2015095301A2 ADC-11 linker |
[12] |
WO2015095301A2 ADC-12 antibody
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
WO2015095301A2 ADC-12 |
WO2015095301A2 ADC-12 payload |
Undisclosed |
WO2015095301A2 ADC-12 linker |
[12] |
WO2015095301A2 ADC-13 antibody
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
WO2015095301A2 ADC-13 |
WO2015095301A2 ADC-13 payload |
Undisclosed |
WO2015095301A2 ADC-13 linker |
[12] |
WO2015095301A2 ADC-14 antibody
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
WO2015095301A2 ADC-14 |
WO2015095301A2 ADC-14 payload |
Undisclosed |
WO2015095301A2 ADC-14 linker |
[12] |
WO2015095301A2 ADC-15 antibody
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
WO2015095301A2 ADC-15 |
WO2015095301A2 ADC-15 payload |
Undisclosed |
WO2015095301A2 ADC-15 linker |
[12] |
WO2015095301A2 ADC-16 antibody
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
WO2015095301A2 ADC-16 |
WO2015095301A2 ADC-16 payload |
Undisclosed |
WO2015095301A2 ADC-16 linker |
[12] |
WO2015095301A2 ADC-17 antibody
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
WO2015095301A2 ADC-17 |
WO2015095301A2 ADC-17 payload |
Undisclosed |
WO2015095301A2 ADC-17 linker |
[12] |
WO2015095301A2 ADC-18 antibody
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
WO2015095301A2 ADC-18 |
WO2015095301A2 ADC-18 payload |
Undisclosed |
WO2015095301A2 ADC-18 linker |
[12] |
WO2015095301A2 ADC-19 antibody
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
WO2015095301A2 ADC-19 |
WO2015095301A2 ADC-19 payload |
Undisclosed |
WO2015095301A2 ADC-19 linker |
[12] |
WO2015095301A2 ADC-2 antibody
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
WO2015095301A2 ADC-2 |
WO2015095301A2 ADC-2 payload |
Undisclosed |
WO2015095301A2 ADC-2 linker |
[12] |
WO2015095301A2 ADC-20 antibody
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
WO2015095301A2 ADC-20 |
WO2015095301A2 ADC-20 payload |
Undisclosed |
WO2015095301A2 ADC-20 linker |
[12] |
WO2015095301A2 ADC-21 antibody
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
WO2015095301A2 ADC-21 |
WO2015095301A2 ADC-21 payload |
Undisclosed |
WO2015095301A2 ADC-21 linker |
[12] |
WO2015095301A2 ADC-22 antibody
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
WO2015095301A2 ADC-22 |
WO2015095301A2 ADC-22 payload |
Undisclosed |
WO2015095301A2 ADC-22 linker |
[12] |
WO2015095301A2 ADC-23 antibody
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
WO2015095301A2 ADC-23 |
WO2015095301A2 ADC-23 payload |
Undisclosed |
WO2015095301A2 ADC-23 linker |
[12] |
WO2015095301A2 ADC-24 antibody
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
WO2015095301A2 ADC-24 |
WO2015095301A2 ADC-24 payload |
Undisclosed |
WO2015095301A2 ADC-24 linker |
[12] |
WO2015095301A2 ADC-25 antibody
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
WO2015095301A2 ADC-25 |
WO2015095301A2 ADC-25 payload |
Undisclosed |
WO2015095301A2 ADC-25 linker |
[12] |
WO2015095301A2 ADC-26 antibody
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
WO2015095301A2 ADC-26 |
WO2015095301A2 ADC-26 payload |
Undisclosed |
WO2015095301A2 ADC-26 linker |
[12] |
WO2015095301A2 ADC-27 antibody
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
WO2015095301A2 ADC-27 |
WO2015095301A2 ADC-27 payload |
Undisclosed |
WO2015095301A2 ADC-27 linker |
[12] |
WO2015095301A2 ADC-3 antibody
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
WO2015095301A2 ADC-3 |
WO2015095301A2 ADC-3 payload |
Undisclosed |
WO2015095301A2 ADC-3 linker |
[12] |
WO2015095301A2 ADC-4 antibody
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
WO2015095301A2 ADC-4 |
WO2015095301A2 ADC-4 payload |
Undisclosed |
WO2015095301A2 ADC-4 linker |
[12] |
WO2015095301A2 ADC-5 antibody
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
WO2015095301A2 ADC-5 |
WO2015095301A2 ADC-5 payload |
Undisclosed |
WO2015095301A2 ADC-5 linker |
[12] |
WO2015095301A2 ADC-6 antibody
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
WO2015095301A2 ADC-6 |
WO2015095301A2 ADC-6 payload |
Undisclosed |
WO2015095301A2 ADC-6 linker |
[12] |
WO2015095301A2 ADC-7 antibody
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
WO2015095301A2 ADC-7 |
WO2015095301A2 ADC-7 payload |
Undisclosed |
WO2015095301A2 ADC-7 linker |
[12] |
WO2015095301A2 ADC-8 antibody
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
WO2015095301A2 ADC-8 |
WO2015095301A2 ADC-8 payload |
Undisclosed |
WO2015095301A2 ADC-8 linker |
[12] |
WO2015095301A2 ADC-9 antibody
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
WO2015095301A2 ADC-9 |
WO2015095301A2 ADC-9 payload |
Undisclosed |
WO2015095301A2 ADC-9 linker |
[12] |
WO2015189791A1 ADC-1 antibody
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
WO2015189791A1 ADC-1 |
WO2015189791A1 ADC-1 payload |
Undisclosed |
WO2015189791A1 ADC-1 linker |
[13] |
WO2015189791A1 ADC-10 antibody
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
WO2015189791A1 ADC-10 |
WO2015189791A1 ADC-10 payload |
Undisclosed |
WO2015189791A1 ADC-10 linker |
[13] |
WO2015189791A1 ADC-11 antibody
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
WO2015189791A1 ADC-11 |
WO2015189791A1 ADC-11 payload |
Undisclosed |
WO2015189791A1 ADC-11 linker |
[13] |
WO2015189791A1 ADC-12 antibody
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
WO2015189791A1 ADC-12 |
WO2015189791A1 ADC-12 payload |
Undisclosed |
WO2015189791A1 ADC-12 linker |
[13] |
WO2015189791A1 ADC-13 antibody
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
WO2015189791A1 ADC-13 |
WO2015189791A1 ADC-13 payload |
Undisclosed |
WO2015189791A1 ADC-13 linker |
[13] |
WO2015189791A1 ADC-14 antibody
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
WO2015189791A1 ADC-14 |
WO2015189791A1 ADC-14 payload |
Undisclosed |
WO2015189791A1 ADC-14 linker |
[13] |
WO2015189791A1 ADC-15 antibody
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
WO2015189791A1 ADC-15 |
WO2015189791A1 ADC-15 payload |
Undisclosed |
WO2015189791A1 ADC-15 linker |
[13] |
WO2015189791A1 ADC-16 antibody
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
WO2015189791A1 ADC-16 |
WO2015189791A1 ADC-16 payload |
Undisclosed |
WO2015189791A1 ADC-16 linker |
[13] |
WO2015189791A1 ADC-17 antibody
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
WO2015189791A1 ADC-17 |
WO2015189791A1 ADC-17 payload |
Undisclosed |
WO2015189791A1 ADC-17 linker |
[13] |
WO2015189791A1 ADC-18 antibody
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
WO2015189791A1 ADC-18 |
WO2015189791A1 ADC-18 payload |
Undisclosed |
WO2015189791A1 ADC-18 linker |
[13] |
WO2015189791A1 ADC-19 antibody
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
WO2015189791A1 ADC-19 |
WO2015189791A1 ADC-19 payload |
Undisclosed |
WO2015189791A1 ADC-19 linker |
[13] |
WO2015189791A1 ADC-2 antibody
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
WO2015189791A1 ADC-2 |
WO2015189791A1 ADC-2 payload |
Undisclosed |
WO2015189791A1 ADC-2 linker |
[13] |
WO2015189791A1 ADC-20 antibody
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
WO2015189791A1 ADC-20 |
WO2015189791A1 ADC-20 payload |
Undisclosed |
WO2015189791A1 ADC-20 linker |
[13] |
WO2015189791A1 ADC-21 antibody
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
WO2015189791A1 ADC-21 |
WO2015189791A1 ADC-21 payload |
Undisclosed |
WO2015189791A1 ADC-21 linker |
[13] |
WO2015189791A1 ADC-22 antibody
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
WO2015189791A1 ADC-22 |
WO2015189791A1 ADC-22 payload |
Undisclosed |
WO2015189791A1 ADC-22 linker |
[13] |
WO2015189791A1 ADC-23 antibody
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
WO2015189791A1 ADC-23 |
WO2015189791A1 ADC-23 payload |
Undisclosed |
WO2015189791A1 ADC-23 linker |
[13] |
WO2015189791A1 ADC-24 antibody
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
WO2015189791A1 ADC-24 |
WO2015189791A1 ADC-24 payload |
Undisclosed |
WO2015189791A1 ADC-24 linker |
[13] |
WO2015189791A1 ADC-25 antibody
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
WO2015189791A1 ADC-25 |
WO2015189791A1 ADC-25 payload |
Undisclosed |
WO2015189791A1 ADC-25 linker |
[13] |
WO2015189791A1 ADC-26 antibody
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
WO2015189791A1 ADC-26 |
WO2015189791A1 ADC-26 payload |
Undisclosed |
WO2015189791A1 ADC-26 linker |
[13] |
WO2015189791A1 ADC-3 antibody
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
WO2015189791A1 ADC-3 |
WO2015189791A1 ADC-3 payload |
Undisclosed |
WO2015189791A1 ADC-3 linker |
[13] |
WO2015189791A1 ADC-38 antibody
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
WO2015189791A1 ADC-38 |
WO2015189791A1 ADC-38 payload |
Undisclosed |
WO2015189791A1 ADC-38 linker |
[13] |
WO2015189791A1 ADC-39 antibody
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
WO2015189791A1 ADC-39 |
WO2015189791A1 ADC-39 payload |
Undisclosed |
WO2015189791A1 ADC-39 linker |
[13] |
WO2015189791A1 ADC-4 antibody
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
WO2015189791A1 ADC-4 |
WO2015189791A1 ADC-4 payload |
Undisclosed |
WO2015189791A1 ADC-4 linker |
[13] |
WO2015189791A1 ADC-41 antibody
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
WO2015189791A1 ADC-41 |
WO2015189791A1 ADC-41 payload |
Undisclosed |
WO2015189791A1 ADC-41 linker |
[13] |
WO2015189791A1 ADC-42 antibody
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
WO2015189791A1 ADC-42 |
WO2015189791A1 ADC-42 payload |
Undisclosed |
WO2015189791A1 ADC-42 linker |
[13] |
WO2015189791A1 ADC-43 antibody
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
WO2015189791A1 ADC-43 |
WO2015189791A1 ADC-43 payload |
Undisclosed |
WO2015189791A1 ADC-43 linker |
[13] |
WO2015189791A1 ADC-44 antibody
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
WO2015189791A1 ADC-44 |
WO2015189791A1 ADC-44 payload |
Undisclosed |
WO2015189791A1 ADC-44 linker |
[13] |
WO2015189791A1 ADC-45 antibody
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
WO2015189791A1 ADC-45 |
WO2015189791A1 ADC-45 payload |
Undisclosed |
WO2015189791A1 ADC-45 linker |
[13] |
WO2015189791A1 ADC-46 antibody
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
WO2015189791A1 ADC-46 |
WO2015189791A1 ADC-46 payload |
Undisclosed |
WO2015189791A1 ADC-46 linker |
[13] |
WO2015189791A1 ADC-47 antibody
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
WO2015189791A1 ADC-47 |
WO2015189791A1 ADC-47 payload |
Undisclosed |
WO2015189791A1 ADC-47 linker |
[13] |
WO2015189791A1 ADC-48 antibody
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
WO2015189791A1 ADC-48 |
WO2015189791A1 ADC-48 payload |
Undisclosed |
WO2015189791A1 ADC-48 linker |
[13] |
WO2015189791A1 ADC-49 antibody
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
WO2015189791A1 ADC-49 |
WO2015189791A1 ADC-49 payload |
Undisclosed |
WO2015189791A1 ADC-49 linker |
[13] |
WO2015189791A1 ADC-5 antibody
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
WO2015189791A1 ADC-5 |
WO2015189791A1 ADC-5 payload |
Undisclosed |
WO2015189791A1 ADC-5 linker |
[13] |
WO2015189791A1 ADC-50 antibody
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
WO2015189791A1 ADC-50 |
WO2015189791A1 ADC-50 payload |
Undisclosed |
WO2015189791A1 ADC-50 linker |
[13] |
WO2015189791A1 ADC-51 antibody
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
WO2015189791A1 ADC-51 |
WO2015189791A1 ADC-51 payload |
Undisclosed |
WO2015189791A1 ADC-51 linker |
[13] |
WO2015189791A1 ADC-52 antibody
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
WO2015189791A1 ADC-52 |
WO2015189791A1 ADC-52 payload |
Undisclosed |
WO2015189791A1 ADC-52 linker |
[13] |
WO2015189791A1 ADC-53 antibody
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
WO2015189791A1 ADC-53 |
WO2015189791A1 ADC-53 payload |
Undisclosed |
WO2015189791A1 ADC-53 linker |
[13] |
WO2015189791A1 ADC-54 antibody
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
WO2015189791A1 ADC-54 |
WO2015189791A1 ADC-54 payload |
Undisclosed |
WO2015189791A1 ADC-54 linker |
[13] |
WO2015189791A1 ADC-55 antibody
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
WO2015189791A1 ADC-55 |
WO2015189791A1 ADC-55 payload |
Undisclosed |
WO2015189791A1 ADC-55 linker |
[13] |
WO2015189791A1 ADC-56 antibody
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
WO2015189791A1 ADC-56 |
WO2015189791A1 ADC-56 payload |
Undisclosed |
WO2015189791A1 ADC-56 linker |
[13] |
WO2015189791A1 ADC-57 antibody
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
WO2015189791A1 ADC-57 |
WO2015189791A1 ADC-57 payload |
Undisclosed |
WO2015189791A1 ADC-57 linker |
[13] |
WO2015189791A1 ADC-58 antibody
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
WO2015189791A1 ADC-58 |
WO2015189791A1 ADC-58 payload |
Undisclosed |
WO2015189791A1 ADC-58 linker |
[13] |
WO2015189791A1 ADC-59 antibody
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
WO2015189791A1 ADC-59 |
WO2015189791A1 ADC-59 payload |
Undisclosed |
WO2015189791A1 ADC-59 linker |
[13] |
WO2015189791A1 ADC-6 antibody
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
WO2015189791A1 ADC-6 |
WO2015189791A1 ADC-6 payload |
Undisclosed |
WO2015189791A1 ADC-6 linker |
[13] |
WO2015189791A1 ADC-60 antibody
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
WO2015189791A1 ADC-60 |
WO2015189791A1 ADC-60 payload |
Undisclosed |
WO2015189791A1 ADC-60 linker |
[13] |
WO2015189791A1 ADC-62 antibody
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
WO2015189791A1 ADC-62 |
WO2015189791A1 ADC-62 payload |
Undisclosed |
WO2015189791A1 ADC-62 linker |
[13] |
WO2015189791A1 ADC-65 antibody
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
WO2015189791A1 ADC-65 |
WO2015189791A1 ADC-65 payload |
Undisclosed |
WO2015189791A1 ADC-65 linker |
[13] |
WO2015189791A1 ADC-7 antibody
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
WO2015189791A1 ADC-7 |
WO2015189791A1 ADC-7 payload |
Undisclosed |
WO2015189791A1 ADC-7 linker |
[13] |
WO2015189791A1 ADC-8 antibody
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
WO2015189791A1 ADC-8 |
WO2015189791A1 ADC-8 payload |
Undisclosed |
WO2015189791A1 ADC-8 linker |
[13] |
WO2015189791A1 ADC-9 antibody
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
WO2015189791A1 ADC-9 |
WO2015189791A1 ADC-9 payload |
Undisclosed |
WO2015189791A1 ADC-9 linker |
[13] |
XMT-1519
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
XMT-1519 Conjugate 1 |
Undisclosed |
Undisclosed |
Undisclosed |
[4] |
ZA202500114A-mAb-1
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
ZA202500114A-ADC-1 |
Monomethyl auristatin E |
Microtubule (MT) |
Undisclosed |
[238] | |
ZA202500114A-ADC-2 |
Undisclosed |
Undisclosed |
Undisclosed |
[238] |
Zanidatamab
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
Zanidatamab-ADC-Tb3-1 |
Zanidatamab-ADC-Tb3-1 payload |
Undisclosed |
Zanidatamab-ADC-Tb3-1 linker |
[7] | |
Zanidatamab-ADC-Tb3-2 |
Zanidatamab-ADC-Tb3-2 payload |
Undisclosed |
Zanidatamab-ADC-Tb3-2 linker |
[7] | |
Zanidatamab-ADC-Tb3-3 |
Zanidatamab-ADC-Tb3-3 payload |
Undisclosed |
Zanidatamab-ADC-Tb3-3 linker |
[7] | |
Zanidatamab-ADC-Tb3-4 |
Zanidatamab-ADC-Tb3-4 payload |
Undisclosed |
Zanidatamab-ADC-Tb3-4 linker |
[7] | |
Zanidatamab-ADC-Tb3-5 |
Zanidatamab-ADC-Tb3-5 payload |
Undisclosed |
Zanidatamab-ADC-Tb3-5 linker |
[7] | |
Zanidatamab-ADC-Tb3-6 |
Zanidatamab-ADC-Tb3-6 payload |
Undisclosed |
Zanidatamab-ADC-Tb3-6 linker |
[7] | |
Zanidatamab-ADC-Tb3-7 |
Zanidatamab-ADC-Tb3-7 payload |
Undisclosed |
Zanidatamab-ADC-Tb3-7 linker |
[7] | |
Zanidatamab-ADC-Tb3-8 |
Zanidatamab-ADC-Tb3-8 payload |
Undisclosed |
Zanidatamab-ADC-Tb3-8 linker |
[7] | |
Zanidatamab-ADC-Tb3-9 |
Zanidatamab-ADC-Tb3-9 payload |
Undisclosed |
Zanidatamab-ADC-Tb3-9 linker |
[7] | |
Zanidatamab-ADC-Tb3-10 |
Zanidatamab-ADC-Tb3-10 payload |
Undisclosed |
Zanidatamab-ADC-Tb3-10 linker |
[7] |
ZHER2
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
ZHER2-Gly3-VC-PAB-MMAF |
Monomethyl auristatin F |
Microtubule (MT) |
Gly3-VC-PAB |
[301] | |
ZHER2-Gly3-VC-PAB-MMAE |
Monomethyl auristatin E |
Microtubule (MT) |
Gly3-VC-PAB |
[301] |
ZHER2-ABD
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
ZHER2-ABD-mcMMAF |
Monomethyl auristatin F |
Microtubule (MT) |
Maleimido-caproyl |
[302] | |
ZHER2-ABD-mcMMAE |
Monomethyl auristatin E |
Microtubule (MT) |
Maleimido-caproyl |
[302] |
ZHER2:342-Cupid-His
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
ZHER2:342-Cupid-His-Ax-SiPc |
Silicon Phthalocyanine |
Undisclosed |
Psyche-Ax |
[303] |
Zr-labeled trastuzumab
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
89Zr-DFO-T-DM1 |
Mertansine DM1 |
Microtubule (MT) |
Undisclosed |
[145] |
Undisclosed
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
Recombinant anti-HER2 humanized mAb-DM1 |
Mertansine DM1 |
Microtubule (MT) |
Undisclosed |
||
MT-5111 |
Shiga toxin B subunit (StxB) |
Ribosome (RB) |
Undisclosed |
||
KM254-ADC |
Undisclosed |
Undisclosed |
Undisclosed |
[304] | |
Xl-250 |
Undisclosed |
Undisclosed |
Undisclosed |
[305] | |
Anti-HER2 antibody-drug conjugate (XDCExplorer) |
Undisclosed |
Undisclosed |
Undisclosed |
[306] | |
YB1-ADC-HER2 |
Undisclosed |
Undisclosed |
Undisclosed |
[307] | |
Biparatopic HER2/HER2 antibody drug conjugate |
Undisclosed |
Undisclosed |
Undisclosed |
[308] | |
Anti-HER2-4AP ADC |
Undisclosed |
Undisclosed |
Undisclosed |
[309] | |
Anti-HER2 antibody drug conjugate (NBE-Therapeutics) |
Undisclosed |
Undisclosed |
Undisclosed |
[310] | |
Anti-HER2 antibody-drug conjugate (Mersana Therapeutics/Genentech) |
Undisclosed |
Undisclosed |
Undisclosed |
[311] | |
Mabion-HER2 ADC |
Undisclosed |
Undisclosed |
Undisclosed |
[312] | |
Antibody drug conjugate targeting HER2 (IntoCell) |
Undisclosed |
Undisclosed |
Undisclosed |
[313] | |
TE-1218 |
Undisclosed |
Undisclosed |
Undisclosed |
[314] | |
TE-1112 |
Undisclosed |
Undisclosed |
Undisclosed |
[315] | |
Second Generation HER2-Directed Antibody-Drug conjugate |
Undisclosed |
Undisclosed |
Undisclosed |
[316] | |
Chloromethylbenz-Indoline Dimer Antibody Drug conjugate |
Undisclosed |
Undisclosed |
Undisclosed |
[317] | |
XB3-001 |
Undisclosed |
Undisclosed |
Undisclosed |
[318] | |
ANT-043 |
Undisclosed |
Undisclosed |
Undisclosed |
[319] | |
AbGn-110 |
Undisclosed |
Undisclosed |
Undisclosed |
[320] | |
CTAT-ADC |
Mertansine DM1 |
Microtubule (MT) |
Undisclosed |
[321] | |
Humanized Anti-HER2 Mab-Maytansine Conjugate |
Mertansine DM1 |
Microtubule (MT) |
Undisclosed |
[322] | |
DAN-311 |
Camptothecin |
DNA topoisomerase 1 (TOP1) |
Undisclosed |
[323] | |
JAB-BX400 |
STING agonist |
Stimulator of interferon genes protein (STING1) |
Undisclosed |
[324] | |
QBK249-G |
Undisclosed |
Undisclosed |
Undisclosed |
[325] | |
Antibody-drug conjugate (Scripps) |
Undisclosed |
Undisclosed |
Undisclosed |
[326] | |
FS-1502 |
Monomethyl auristatin F |
Microtubule (MT) |
Undisclosed |
||
ZV-0203 |
Undisclosed |
Undisclosed |
Undisclosed |
[328] | |
FDA022-BB05 |
Undisclosed |
Undisclosed |
Undisclosed |
[329] | |
HS630 |
Mertansine DM1 |
Microtubule (MT) |
Undisclosed |
[330] | |
CN114106088A ADC6 |
Tubulin inhibitor B |
Microtubule (MT) |
CN114106088A+ADC1+Linker |
[347] | |
CN114106088A ADC7 |
Tubulin inhibitor B |
Microtubule (MT) |
CN114106088A+ADC2+Linker |
[347] | |
CN114106088A ADC8 |
Tubulin inhibitor B |
Microtubule (MT) |
CN114106088A+ADC3+Linker |
[347] | |
CN114106088A ADC9 |
Tubulin inhibitor B |
Microtubule (MT) |
CN114106088A+ADC4+Linker |
[347] | |
CN114106088A ADC10 |
Tubulin inhibitor B |
Microtubule (MT) |
CN114106088A+ADC5+Linker |
[347] | |
US12195552B2 ADC41 |
undisclosed |
Undisclosed |
Undisclosed |
[348] | |
US12195552B2 ADC42 |
undisclosed |
Undisclosed |
Undisclosed |
[348] | |
US12195552B2 ADC43 |
undisclosed |
Undisclosed |
Undisclosed |
[348] | |
US12195552B2 ADC44 |
undisclosed |
Undisclosed |
Undisclosed |
[348] | |
US12195552B2 ADC45 |
undisclosed |
Undisclosed |
Undisclosed |
[348] | |
US12195552B2 ADC46 |
undisclosed |
Undisclosed |
Undisclosed |
[348] | |
US12195552B2 ADC47 |
undisclosed |
Undisclosed |
Undisclosed |
[348] | |
US12195552B2 ADC48 |
undisclosed |
Undisclosed |
Undisclosed |
[348] | |
BR122024023391 antibody-drug conjugate (1) |
undisclosed |
Undisclosed |
Undisclosed |
[349] | |
WO2024118785A3 Lot1 |
Undisclosed |
Undisclosed |
Undisclosed |
[69] | |
WO2024118785A3 Lot8 |
Undisclosed |
Undisclosed |
Undisclosed |
[69] | |
WO2024118785A3 Lot9 |
Undisclosed |
Undisclosed |
Undisclosed |
[69] | |
WO2024118785A3 Lot13 |
Undisclosed |
Undisclosed |
Undisclosed |
[69] | |
WO2024118785A3 Lot15 |
Undisclosed |
Undisclosed |
Undisclosed |
[69] | |
WO2024118785A3 Lot16 |
Undisclosed |
Undisclosed |
Undisclosed |
[69] | |
WO2024118785A3 Lot17 |
Undisclosed |
Undisclosed |
Undisclosed |
[69] | |
WO2024118785A3 Lot25 |
Undisclosed |
Undisclosed |
Undisclosed |
[69] | |
WO2024118785A3 Lot26 |
Undisclosed |
Undisclosed |
Undisclosed |
[69] | |
WO2024118785A3 Lot27 |
Undisclosed |
Undisclosed |
Undisclosed |
[69] | |
WO2024118785A3 Lot28 |
P9 |
Undisclosed |
Undisclosed |
[69] | |
WO2024118785A3 Lot29 |
Undisclosed |
Undisclosed |
Undisclosed |
[69] | |
WO2024118785A3 Lot30 |
Undisclosed |
Undisclosed |
Undisclosed |
[69] | |
WO2024118785A3 Lot31 |
Undisclosed |
Undisclosed |
Undisclosed |
[69] | |
WO2024118785A3 Lot32 |
Undisclosed |
Undisclosed |
Undisclosed |
[69] | |
WO2024118785A3 Lot37 |
Undisclosed |
Undisclosed |
Undisclosed |
[69] | |
WO2024118785A3 Lot44 |
Undisclosed |
Undisclosed |
Undisclosed |
[69] | |
WO2024118785A3 Lot45 |
Undisclosed |
Undisclosed |
Undisclosed |
[69] | |
WO2024118785A3 Lot46 |
Undisclosed |
Undisclosed |
Undisclosed |
[69] | |
WO2024118785A3 Lot47 |
P9 |
Undisclosed |
Undisclosed |
[69] | |
WO2024118785A3 Lot51 |
Undisclosed |
Undisclosed |
Undisclosed |
[69] | |
WO2024118785A3 Lot60 |
P9 |
Undisclosed |
Undisclosed |
[69] | |
WO2024118785A3 Lot63 |
P9 |
Undisclosed |
Undisclosed |
[69] | |
WO2024118785A3 Lot72 |
Undisclosed |
Undisclosed |
Undisclosed |
[69] | |
WO2024118785A3 Lot73 |
Undisclosed |
Undisclosed |
Undisclosed |
[69] | |
WO2024118785A3 Lot81 |
Undisclosed |
Undisclosed |
Undisclosed |
[69] | |
WO2024118785A3 Lot82 |
P9 |
Undisclosed |
Undisclosed |
[69] | |
WO2024118785A3 Lot83 |
P9 |
Undisclosed |
Undisclosed |
[69] | |
WO2024118785A3 Lot84 |
Undisclosed |
Undisclosed |
Undisclosed |
[69] | |
WO2024118785A3 Lot85 |
Undisclosed |
Undisclosed |
Undisclosed |
[69] | |
WO2024118785A3 Lot86 |
P9 |
Undisclosed |
Undisclosed |
[69] | |
WO2024118785A3 Lot87 |
P9 |
Undisclosed |
Undisclosed |
[69] | |
WO2024118785A3 Lot88 |
Undisclosed |
Undisclosed |
Undisclosed |
[69] | |
WO2024118785A3 Lot89 |
Undisclosed |
Undisclosed |
Undisclosed |
[69] | |
WO2024118785A3 Lot90 |
Undisclosed |
Undisclosed |
Undisclosed |
[69] |
undisclosed
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
H-1-VcMMAE |
Undisclosed |
Undisclosed |
Undisclosed |
[327] | |
H-3-VcMMAE |
Undisclosed |
Undisclosed |
Undisclosed |
[327] | |
H-4-VcMMAE |
Undisclosed |
Undisclosed |
Undisclosed |
[327] | |
JY201 |
Undisclosed |
Undisclosed |
Mc-Val-Cit-PABC |
[86] | |
Anti-Her2_ (Q295)_AsnAsnPABC_MMAE |
Monomethyl auristatin E |
Microtubule (MT) |
AsnAsnPABC |
[331] | |
Anti-Her2_ (Q295)_AsnAlaPABC_MMAE |
Monomethyl auristatin E |
Microtubule (MT) |
AsnAlaPABC |
[331] | |
Antl-Her2_ (0295)_ValAlaPABC_MMAE |
Monomethyl auristatin E |
Microtubule (MT) |
Mc-Val-Ala-PABC |
[331] | |
Anti-Her2_AsnAsnPABC_MMAE |
Monomethyl auristatin E |
Microtubule (MT) |
AsnAsnPABC |
[331] | |
Anti-Her2_AsnAlaPABC_MMAE |
Monomethyl auristatin E |
Microtubule (MT) |
AsnAlaPABC |
[331] | |
Anti-Her2_ValCitPABC_MMAE |
Monomethyl auristatin E |
Microtubule (MT) |
Mc-Val-Cit-PABC |
[331] | |
HER2-11 |
WL-14 |
Undisclosed |
Undisclosed |
[332] | |
HER2-STINGa |
STINGa |
Undisclosed |
Undisclosed |
[333] | |
HER2-B |
TLR7/8 agonist B |
Undisclosed |
Succinimidyl-4- (N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC) |
[334] | |
HER2-A |
TLR7/8 agonist A |
Undisclosed |
Succinimidyl-4- (N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC) |
[334] | |
HER2-A (Fc null) |
TLR7/8 agonist A |
Undisclosed |
Succinimidyl-4- (N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC) |
[334] | |
HLX91-048 ADC (DAR 4) |
HLX91-048 |
Undisclosed |
Undisclosed |
[335] | |
HLX91-048 ADC (DAR 8) |
HLX91-048 |
Undisclosed |
Undisclosed |
[335] | |
aHer2- (AL6-LP1)n |
DX-8951 derivative (DXd) |
DNA topoisomerase 1 (TOP1) |
US20240269308A1 aHer2- (AL6-LP1)n Linker |
[336] | |
aHer2- (AL6-LP15)n |
DX-8951 derivative (DXd) |
DNA topoisomerase 1 (TOP1) |
US20240269308A1 aHer2- (AL6-LP15)n Linker |
[336] | |
aHer2- (AL6-LP13)n |
DX-8951 derivative (DXd) |
DNA topoisomerase 1 (TOP1) |
US20240269308A1 aHer2- (AL6-LP13)n Linker |
[336] | |
aHer2- (AL7-LP1)n |
DX-8951 derivative (DXd) |
DNA topoisomerase 1 (TOP1) |
US20240269308A1 aHer2- (AL6-LP1)n Linker |
[336] | |
aHer2- (AL7-LP13)n |
DX-8951 derivative (DXd) |
DNA topoisomerase 1 (TOP1) |
US20240269308A1 aHer2- (AL6-LP13)n Linker |
[336] | |
aHer2- (AL7-LP2)n |
CP1412 |
Undisclosed |
US20240269308A1 aHer2- (AL6-LP1)n Linker |
[336] | |
aHer2- (AL7-LP3)n |
CP1408 |
Undisclosed |
US20240269308A1 aHer2- (AL6-LP1)n Linker |
[336] | |
aHer2- (AL7-LP4)n |
CP1409 |
Undisclosed |
US20240269308A1 aHer2- (AL6-LP1)n Linker |
[336] | |
aHer2- (AL7-LP5)n |
CP1436 |
DNA topoisomerase I (TOP1) |
US20240269308A1 aHer2- (AL7-LP5)n Linker |
[336] | |
aHer2- (AL7-LP7)n |
CP1411 |
Undisclosed |
US20240269308A1 aHer2- (AL6-LP1)n Linker |
[336] | |
aHer2- (AL7-LP9)n |
CP1422 |
Undisclosed |
US20240269308A1 aHer2- (AL7-LP5)n Linker |
[336] | |
aHer2- (AL7-LP12)n |
CP1436 |
DNA topoisomerase I (TOP1) |
US20240269308A1 aHer2- (AL7-LP5)n Linker |
[336] | |
aHer2- (AL7-LP5D)n |
CP1436 |
DNA topoisomerase I (TOP1) |
US20240269308A1 aHer2- (AL7-LP5D)n Linker |
[336] | |
aHer2- (AL4c-LP1B)n |
DX-8951 derivative (DXd) |
DNA topoisomerase 1 (TOP1) |
US20240269308A1 aHer2- (AL4c-LP1B)n Linker |
[336] | |
aHer2- (AL4c-LP13C)n |
DX-8951 derivative (DXd) |
DNA topoisomerase 1 (TOP1) |
US20240269308A1 aHer2- (AL4c-LP13C)n Linker |
[336] | |
aHer2- (AL11a-LP1)n |
DX-8951 derivative (DXd) |
DNA topoisomerase 1 (TOP1) |
US20240269308A1 aHer2- (AL6-LP1)n Linker |
[336] | |
aHer2- (AL11a-LP13)n |
DX-8951 derivative (DXd) |
DNA topoisomerase 1 (TOP1) |
US20240269308A1 aHer2- (AL6-LP13)n Linker |
[336] | |
aHer2- (AL11a-LP15)n |
DX-8951 derivative (DXd) |
DNA topoisomerase 1 (TOP1) |
US20240269308A1 aHer2- (AL6-LP15)n Linker |
[336] | |
aHer2- (BL1-LP1)n |
DX-8951 derivative (DXd) |
DNA topoisomerase 1 (TOP1) |
US20240269308A1 aHer2- (AL6-LP1)n Linker |
[336] | |
aHer2- (BL1-LP13)n |
DX-8951 derivative (DXd) |
DNA topoisomerase 1 (TOP1) |
US20240269308A1 aHer2- (AL6-LP13)n Linker |
[336] | |
aHer2- (BL3b-LP1)n |
DX-8951 derivative (DXd) |
DNA topoisomerase 1 (TOP1) |
US20240269308A1 aHer2- (AL6-LP1)n Linker |
[336] | |
HK40112818A Anti-Her2-AL1- LP9 |
US12209180B2 P3 |
Undisclosed |
Anti-Her2-AL1- LP9 LINKER |
[337] | |
HK40112818A Anti-Her2-AL1- LP4 |
US12209180B2 P3 |
Undisclosed |
Anti-Her2-AL1- LP4 LINKER |
[337] | |
HK40112818A Anti-Her2-AL1- LP3 |
US12209180B2 P3 |
Undisclosed |
Anti-Her2-AL1- LP3 LINKER |
[337] | |
HK40112818A Anti-Her2-AL1- LP1 |
US12209180B2 P3 |
Undisclosed |
Anti-Her2-AL1- LP1 LINKER |
[337] | |
HK40112818A Anti-Her2-BL2- LP1 |
US12209180B2 P3 |
Undisclosed |
Anti-Her2-AL1- LP1 LINKER |
[337] | |
HK40112818A Anti-Her2-AL1- LP2 |
US12209180B2 P3 |
Undisclosed |
Anti-Her2-AL1- LP2 LINKER |
[337] | |
HK40112818A Anti-Her2-AL1- LP20 |
US12209180B2 P3 |
Undisclosed |
Anti-Her2-AL1- LP20 LINKER |
[337] | |
HK40112818A Anti-Her2-AL1- LP22 |
US12209180B2 P3 |
Undisclosed |
Anti-Her2-AL1- LP22 linker |
[337] | |
HK40112818A Anti-Her2-BL2- LP22 |
US12209180B2 P3 |
Undisclosed |
Anti-Her2-AL1- LP22 linker |
[337] | |
HK40112818A Anti-Her2-AL1- LP10 |
US12209180B2 P3 |
Undisclosed |
Anti-Her2-AL1- LP10 linker |
[337] | |
HK40112818A Anti-Her2-AL1- LP11 |
US12209180B2 P3 |
Undisclosed |
Anti-Her2-AL1- LP11 linker |
[337] | |
HK40112818A Anti-Her2-AL1- LP12 |
US12209180B2 P3 |
Undisclosed |
Anti-Her2-AL1- LP12 linker |
[337] | |
HK40112818A Anti-Her2-AL1- LP23 |
Undisclosed |
Undisclosed |
Anti-Her2-AL1- LP23 linker |
[337] | |
HK40112818A Anti-Her2-AL1- LP24 |
Undisclosed |
Undisclosed |
Anti-Her2-AL1- LP24 linker |
[337] | |
HK40112818A Anti-Her2-AL1- LP25 |
Undisclosed |
Undisclosed |
Anti-Her2-AL1- LP25 linker |
[337] | |
HK40112818A Anti-Her2-AL1- LP26 |
Undisclosed |
Undisclosed |
Anti-Her2-AL1- LP26 linker |
[337] | |
HK40112818A Anti-Her2-AL1- LP28 |
Undisclosed |
Undisclosed |
Anti-Her2-AL1- LP28 linker |
[337] | |
Control-AL1- LP28 |
Undisclosed |
Undisclosed |
Anti-Her2-AL1- LP28 linker |
[337] | |
HK40112818A Anti-Her2-BL21- LP28 |
Undisclosed |
Undisclosed |
Anti-Her2-AL1- LP28 linker |
[337] | |
HK40112818A Anti-Her2-AL1- LP30 |
Undisclosed |
Undisclosed |
Anti-Her2-AL1- LP30 linker |
[337] | |
HK40112818A Anti-Her2-AL1- LP32 |
Undisclosed |
Undisclosed |
Anti-Her2-AL1- LP32 linker |
[337] | |
HK40112818A Anti-Her2-BL2- LP32 |
Undisclosed |
Undisclosed |
Anti-Her2-AL1- LP32 linker |
[337] | |
HK40112818A Anti-Her2-AL1- LP34 |
Undisclosed |
Undisclosed |
Anti-Her2-AL1- LP32 linker |
[337] | |
HK40112818A Anti-Her2-AL1- LP35 |
Undisclosed |
Undisclosed |
Anti-Her2-AL1- LP35 LINKER linker |
[337] | |
HK40112818A Anti-Her2-AL1- LP36 |
Undisclosed |
Undisclosed |
Anti-Her2-AL1- LP36 linker |
[337] | |
HK40112818A Anti-Her2-AL1- LP37 |
Undisclosed |
Undisclosed |
Anti-Her2-AL1- LP37 linker |
[337] | |
HK40112818A Anti-Her2-AL1- LP38 |
Undisclosed |
Undisclosed |
Anti-Her2-AL1- LP38 linker |
[337] | |
HK40112818A Anti-Her2-BL2- LP38 |
Undisclosed |
Undisclosed |
Anti-Her2-AL1- LP38 linker |
[337] | |
HK40112818A Anti-Her2-AL1- LP39 |
Undisclosed |
Undisclosed |
Anti-Her2-AL1- LP41 linker |
[337] | |
HK40112818A Anti-Her2-BL2- LP39 |
Undisclosed |
Undisclosed |
Undisclosed |
[337] | |
HK40112818A Anti-Her2-AL1- LP41 |
Undisclosed |
Undisclosed |
Anti-Her2-AL1- LP40 linker |
[337] | |
HK40112818A Anti-Her2-BL2- LP41 |
Undisclosed |
Undisclosed |
Anti-Her2-AL1- LP41 linker |
[337] | |
HK40112818A Anti-Her2-LP16 |
US12209180B2 P3 |
Undisclosed |
Anti-Her2-LP16 linker |
[337] | |
HK40112818A Anti-Her2-LP21 |
Undisclosed |
Undisclosed |
Anti-Her2-LP21 linker |
[337] | |
HK40112818A Anti-Her2-LP27 |
Undisclosed |
Undisclosed |
Anti-Her2-LP27 linker |
[337] | |
HK40112818A Anti-Her2-LP31 |
Undisclosed |
Undisclosed |
Anti-Her2-LP31 linker |
[337] | |
HK40112818A Anti-Her2-qLP18 |
Undisclosed |
Undisclosed |
Undisclosed |
[337] | |
CA2975383C example16 |
Tubulin inhibitor A |
Undisclosed |
Undisclosed |
[338] | |
CA2975383C example17 |
Tubulin inhibitor A |
Undisclosed |
Undisclosed |
[338] | |
CA2975383C example19 |
Tubulin inhibitor C |
Undisclosed |
Undisclosed |
[338] | |
CA2975383C example64 |
CA2975383C example64 payload |
Undisclosed |
Undisclosed |
[338] | |
CA2975383C example21 |
Tubulin inhibitor A |
Undisclosed |
Undisclosed |
[338] | |
CA2975383C example22 |
Tubulin inhibitor A |
Undisclosed |
Undisclosed |
[338] | |
CA2975383C example23 |
Tubulin inhibitor A |
Undisclosed |
Undisclosed |
[338] | |
CA2975383C example24 |
CA2975383C example24 payload |
Undisclosed |
Undisclosed |
[338] | |
CA2975383C example28 |
Tubulin inhibitor C |
Undisclosed |
Undisclosed |
[338] | |
CA2975383C example65 |
Tubulin inhibitor C |
Undisclosed |
Undisclosed |
[338] | |
WO2024043319A1 78 |
Undisclosed |
Undisclosed |
Undisclosed |
[339] | |
H-1-MMAF |
Undisclosed |
Undisclosed |
Undisclosed |
[327] | |
H-3-MMAF |
Undisclosed |
Undisclosed |
Undisclosed |
[327] | |
H-4-MMAF |
Undisclosed |
Undisclosed |
Undisclosed |
[327] | |
Maa-C6-Val-Ala-PAB-MMAE |
Monomethyl auristatin E |
Microtubule (MT) |
Maa-C6-Val-Ala-PAB |
[78] | |
Maa-C6-Val-Cit-PAB-MMAE |
Monomethyl auristatin E |
Microtubule (MT) |
Maa-C6-Val-Cit-PAB |
[78] | |
Mf-C6-Val-Ala-PAB-MMAE |
Monomethyl auristatin E |
Microtubule (MT) |
Mm-C6-Val-Ala-PAB |
[78] | |
Mf-C3-Val-Ala-PAB-MMAE |
Monomethyl auristatin E |
Microtubule (MT) |
Mm-C3-Val-Ala-PAB |
[78] | |
Mf-C6-Val-Cit-PAB-MMAE |
Monomethyl auristatin E |
Microtubule (MT) |
Mf-C6-Val-Cit-PAB |
[78] | |
Mm-C6-Val-Ala-PAB-MMAE |
Monomethyl auristatin E |
Microtubule (MT) |
Mm-C6-Val-Ala-PAB |
[78] | |
Mm-C3-Val-Ala-PAB-MMAE |
Monomethyl auristatin E |
Microtubule (MT) |
Mm-C3-Val-Ala-PAB |
[78] | |
Mm-C6-Val-Cit-PAB-MMAE |
Monomethyl auristatin E |
Microtubule (MT) |
Mm-C6-Val-Cit-PAB |
[78] | |
JY201b |
Undisclosed |
Undisclosed |
Mc-Val-Cit-PABC |
[86] | |
Ab[AL- LP1] 4 |
Exatecan |
DNA topoisomerase 1 (TOP1) |
Undisclosed |
[340] | |
Ab[AL- LP2] 4 |
Exatecan |
DNA topoisomerase 1 (TOP1) |
Undisclosed |
[340] | |
Ab[AL- LP3] 4 |
Exatecan |
DNA topoisomerase 1 (TOP1) |
Undisclosed |
[340] | |
Ab[AL- LP4] 4 |
Exatecan |
DNA topoisomerase 1 (TOP1) |
Undisclosed |
[340] | |
Ab[AL- LP8] 4 |
Exatecan |
DNA topoisomerase 1 (TOP1) |
Undisclosed |
[340] | |
Ab[AL- LP9] 4 |
Exatecan |
DNA topoisomerase 1 (TOP1) |
Undisclosed |
[340] | |
Ab[AL- LP3] |
Exatecan |
DNA topoisomerase 1 (TOP1) |
Undisclosed |
[340] | |
Ab[AL- LP8] |
Exatecan |
DNA topoisomerase 1 (TOP1) |
Undisclosed |
[340] | |
Ab[AL- LP9] |
DX-8951 derivative (DXd) |
DNA topoisomerase 1 (TOP1) |
Undisclosed |
[340] | |
Ab[AL2- LP1] 4 |
Exatecan |
DNA topoisomerase 1 (TOP1) |
Undisclosed |
[340] | |
Ab[AL2- LP17]n |
DX-8951 derivative (DXd) |
DNA topoisomerase 1 (TOP1) |
Undisclosed |
[340] | |
Ab[AL2- LP17] |
DX-8951 derivative (DXd) |
DNA topoisomerase 1 (TOP1) |
Undisclosed |
[340] | |
JP2025502147A aHer2 Ab |
Undisclosed |
Undisclosed |
Undisclosed |
[340] | |
Isotype Control Ab |
Undisclosed |
Undisclosed |
Undisclosed |
[340] | |
aHer2 (Handle)n |
Undisclosed |
Undisclosed |
Undisclosed |
[340] | |
Isotype Control- (Handle)n |
Undisclosed |
Undisclosed |
Undisclosed |
[340] | |
JP2025502147A ADC1 |
undisclosed |
Undisclosed |
Undisclosed |
[340] | |
JP2025502147A ADC2 |
Undisclosed |
Undisclosed |
Undisclosed |
[340] | |
JP2025502147A ADC3 |
undisclosed |
Undisclosed |
Undisclosed |
[340] | |
Isotype Control ADC |
Undisclosed |
Undisclosed |
Undisclosed |
[340] | |
JP2025502147A ADC4 |
Undisclosed |
Undisclosed |
Undisclosed |
[340] | |
JP2025502147A ADC5 |
Exatecan |
DNA topoisomerase 1 (TOP1) |
Undisclosed |
[340] | |
JP2025502147A ADC6 |
Exatecan |
DNA topoisomerase 1 (TOP1) |
Undisclosed |
[340] | |
JP2025502147A ADC7 |
Exatecan |
DNA topoisomerase 1 (TOP1) |
Undisclosed |
[340] | |
JP2025502147A ADC8 |
Exatecan |
DNA topoisomerase 1 (TOP1) |
Undisclosed |
[340] | |
HER2-L078-055 |
Undisclosed |
Undisclosed |
Undisclosed |
[341] | |
HER2-L078-056 |
Undisclosed |
Undisclosed |
Undisclosed |
[341] | |
HER2-L078-062 |
Undisclosed |
Undisclosed |
Undisclosed |
[341] | |
HER2-L078-063 |
Undisclosed |
Undisclosed |
Undisclosed |
[341] | |
HER2-SET0218 (1) |
Undisclosed |
Undisclosed |
Undisclosed |
[341] | |
STI1499-SET0218 6.2-6.4 |
Undisclosed |
Undisclosed |
Undisclosed |
[341] | |
HER2-L078-030-LT |
Undisclosed |
Undisclosed |
Undisclosed |
[341] | |
HER2-L078-044 |
Undisclosed |
Undisclosed |
Undisclosed |
[341] | |
HER2-L078-045 |
Undisclosed |
Undisclosed |
Undisclosed |
[341] | |
HER2-L078-057 |
Undisclosed |
Undisclosed |
Undisclosed |
[341] | |
HER2-L078-058 |
Undisclosed |
Undisclosed |
Undisclosed |
[341] | |
HER2-L078-059 |
Undisclosed |
Undisclosed |
Undisclosed |
[341] | |
HER2-L078-064 |
Undisclosed |
Undisclosed |
Undisclosed |
[341] | |
HER2-L078-065LT |
Undisclosed |
Undisclosed |
Undisclosed |
[341] | |
HER2-L078-066LT |
Undisclosed |
Undisclosed |
Undisclosed |
[341] | |
HER2-SET0218 (2) |
Undisclosed |
Undisclosed |
Undisclosed |
[341] | |
STI1499-SET0218 3.8-4.1 |
Undisclosed |
Undisclosed |
Undisclosed |
[341] | |
HER2-L079-018 |
Undisclosed |
Undisclosed |
Undisclosed |
[341] | |
HER2-L079-019 |
Undisclosed |
Undisclosed |
Undisclosed |
[341] | |
HER2-L079-027 |
Undisclosed |
Undisclosed |
Undisclosed |
[341] | |
HER2-L079-034 |
Undisclosed |
Undisclosed |
Undisclosed |
[341] | |
HER2-L079-035 |
Undisclosed |
Undisclosed |
Undisclosed |
[341] | |
HER2-L079-040 |
Undisclosed |
Undisclosed |
Undisclosed |
[341] | |
HER2-L078-121 |
Undisclosed |
Undisclosed |
Undisclosed |
[341] | |
HER2-L078-118 |
Undisclosed |
Undisclosed |
Undisclosed |
[341] | |
HER2-L078-119 |
Undisclosed |
Undisclosed |
Undisclosed |
[341] | |
HER2-L078-120 |
Undisclosed |
Undisclosed |
Undisclosed |
[341] | |
HER2-L078-177 |
Undisclosed |
Undisclosed |
Undisclosed |
[341] | |
HER2-L078-130 |
Undisclosed |
Undisclosed |
Undisclosed |
[341] | |
HER2-L078-123 |
Undisclosed |
Undisclosed |
Undisclosed |
[341] | |
HER2-L078-163 |
Undisclosed |
Undisclosed |
Undisclosed |
[341] | |
HER2-L078-164 |
Undisclosed |
Undisclosed |
Undisclosed |
[341] | |
HER2-L078-173 |
Undisclosed |
Undisclosed |
Undisclosed |
[341] | |
HER2-L078-170 |
Undisclosed |
Undisclosed |
Undisclosed |
[341] | |
HER2-L078-171 |
Undisclosed |
Undisclosed |
Undisclosed |
[341] | |
HER2-L078-178 |
Undisclosed |
Undisclosed |
Undisclosed |
[341] | |
HER2-L078-182 |
Undisclosed |
Undisclosed |
Undisclosed |
[341] | |
HER2-L081-034 |
Undisclosed |
Undisclosed |
Undisclosed |
[341] | |
HER2-L081-036 |
Undisclosed |
Undisclosed |
Undisclosed |
[341] | |
HER2-L081-038 |
Undisclosed |
Undisclosed |
Undisclosed |
[341] | |
HER2-Dxd |
DX-8951 derivative (DXd) |
DNA topoisomerase 1 (TOP1) |
Undisclosed |
[341] | |
US20230233540A1+ADC |
Undisclosed |
Undisclosed |
Mc-Gly-Gly-Phe-Gly |
[342] | |
Her2-E380C-L443C |
Undisclosed |
Undisclosed |
Undisclosed |
[343] | |
Her2-L443C 1 |
Undisclosed |
Undisclosed |
Undisclosed |
[343] | |
Her2-E380C 1.9 |
Undisclosed |
Undisclosed |
Undisclosed |
[343] | |
Her2-Q347C 2 |
Undisclosed |
Undisclosed |
Undisclosed |
[343] | |
Her2-Q347C |
Undisclosed |
Undisclosed |
Undisclosed |
[343] | |
Her2-Y373C 1.6 |
Undisclosed |
Undisclosed |
Undisclosed |
[343] | |
Her2-Y373C 1.9 |
Undisclosed |
Undisclosed |
Undisclosed |
[343] | |
Her2-E380C 2 |
Undisclosed |
Undisclosed |
Undisclosed |
[343] | |
Her2-E380C+L443C |
Undisclosed |
Undisclosed |
Undisclosed |
[343] | |
Her2-K392C 2 |
Undisclosed |
Undisclosed |
Undisclosed |
[343] | |
Her2-K392C 1.9 |
Undisclosed |
Undisclosed |
Undisclosed |
[343] | |
Her2-K392C+L443C |
Undisclosed |
Undisclosed |
Undisclosed |
[343] | |
Her2-L398C+L443C |
Undisclosed |
Undisclosed |
Undisclosed |
[343] | |
Her2-N421C 2 |
Undisclosed |
Undisclosed |
Undisclosed |
[343] | |
Her2-N421C 2.1 |
Undisclosed |
Undisclosed |
Undisclosed |
[343] | |
Her2-L443C 2 |
Undisclosed |
Undisclosed |
Undisclosed |
[343] | |
Her2-L443C 3 |
Undisclosed |
Undisclosed |
Undisclosed |
[343] | |
Her2-kappa-A111C |
Undisclosed |
Undisclosed |
Undisclosed |
[343] | |
Her2-kappa-A111C+Q347C |
Undisclosed |
Undisclosed |
Undisclosed |
[343] | |
Her2-kappa-A111C+K392C |
Undisclosed |
Undisclosed |
Undisclosed |
[343] | |
Her2-kappa-A111C+L443C |
Undisclosed |
Undisclosed |
Undisclosed |
[343] | |
Her2-kappa-K149C |
Undisclosed |
Undisclosed |
Undisclosed |
[343] | |
Her2-kappa-K183C |
Undisclosed |
Undisclosed |
Undisclosed |
[343] | |
Her2-kappa-K183C+L443C |
Undisclosed |
Undisclosed |
Undisclosed |
[343] | |
Her2-kappa-K207C |
Undisclosed |
Undisclosed |
Undisclosed |
[343] | |
Her2-kappa-K207C+L443C |
Undisclosed |
Undisclosed |
Undisclosed |
[343] | |
WO2024138000A1 aHer2 Ab |
Undisclosed |
Undisclosed |
Undisclosed |
[344] | |
aHer2- (AL11a)4 |
Undisclosed |
Undisclosed |
Undisclosed |
[344] | |
aHer2- (AL2a)4 |
Undisclosed |
Undisclosed |
Undisclosed |
[344] | |
aHer2- (AL3a)3.94 |
Undisclosed |
Undisclosed |
Undisclosed |
[344] | |
aHer2- (AL7)4 |
Undisclosed |
Undisclosed |
Undisclosed |
[344] | |
aHer2- (AL6)3.6 |
Undisclosed |
Undisclosed |
Undisclosed |
[344] | |
aHer2- (BL1)3.9 |
Undisclosed |
Undisclosed |
Undisclosed |
[344] | |
aHer2- (BL3b)3.8 |
Undisclosed |
Undisclosed |
Undisclosed |
[344] | |
aHer2- (AL6-LP1)3.6 |
aHer2- (AL6-LP1)<sub>3.6</sub> Payload |
Undisclosed |
aHer2- (AL6-LP1)<sub>3.6</sub> Linker |
[344] | |
aHer2- (AL6-LP13D)6.2 |
DX-8951 derivative (DXd) |
DNA topoisomerase 1 (TOP1) |
aHer2- (AL6-LP13D)<sub>6.2</sub> Linker |
[344] | |
aHer2- (AL6-LP13)6.5 |
aHer2- (AL6-LP1)<sub>3.6</sub> Payload |
Undisclosed |
aHer2- (AL6-LP13)<sub>6.5</sub> Linker |
[344] | |
aHer2- (AL7-LP1)3.7 |
aHer2- (AL6-LP1)<sub>3.6</sub> Payload |
Undisclosed |
aHer2- (AL7-LP1)<sub>3.7</sub> Linker |
[344] | |
aHer2- (AL7-LP13)7.3 |
aHer2- (AL6-LP1)<sub>3.6</sub> Payload |
Undisclosed |
aHer2- (AL7-LP13)<sub>7.3</sub> Linker |
[344] | |
aHer2- (AL7-LP2)3.83 |
aHer2- (AL7-LP2)<sub>3.83</sub> Payload |
Undisclosed |
aHer2- (AL7-LP2)<sub>3.83</sub> Linker |
[344] | |
aHer2- (AL7-LP3)3.88 |
DX-8951 derivative (DXd) |
DNA topoisomerase 1 (TOP1) |
aHer2- (AL7-LP2)<sub>3.83</sub> Linker |
[344] | |
aHer2- (AL7-LP4)3.84 |
DX-8951 derivative (DXd) |
DNA topoisomerase 1 (TOP1) |
aHer2- (AL7-LP2)<sub>3.83</sub> Linker |
[344] | |
aHer2- (AL7-LP5)3.80 |
aHer2- (AL7-LP5)<sub>3.80</sub> Payload |
Undisclosed |
aHer2- (AL7-LP5)<sub>3.80</sub> Linker |
[344] | |
aHer2- (AL7-LP7)3.70 |
aHer2- (AL7-LP7)<sub>3.70</sub> Payload |
Undisclosed |
aHer2- (AL7-LP2)<sub>3.83</sub> Linker |
[344] | |
aHer2- (AL7-LP9)3.81 |
undisclosed |
Undisclosed |
aHer2- (AL7-LP2)<sub>3.83</sub> Linker |
[344] | |
aHer2- (AL7-LP12)3.82 |
aHer2- (AL7-LP12)<sub>3.82</sub> Payload |
Undisclosed |
aHer2- (AL7-LP12)<sub>3.82</sub> Linker |
[344] | |
aHer2- (AL7-LP5D)3.89 |
aHer2- (AL7-LP5D)<sub>3.89</sub> Payload |
Undisclosed |
aHer2- (AL7-LP12)<sub>3.82</sub> Linker |
[344] | |
aHer2- (AL7-LP5D)3.90 |
aHer2- (AL7-LP5D)<sub>3.89</sub> Payload |
Undisclosed |
aHer2- (AL7-LP12)<sub>3.82</sub> Linker |
[344] | |
aHer2- (AL4c-LP1B)3.49 |
aHer2- (AL4c-LP1B)<sub>3.49</sub> Payload |
Undisclosed |
aHer2- (AL4c-LP1B)<sub>3.49</sub> Linker |
[344] | |
aHer2- (AL4c-LP13C)7.07 |
undisclosed |
Undisclosed |
aHer2- (AL4c-LP13C)<sub>7.07</sub> Linker |
[344] | |
aHer2- (AL4c-LP13C)7.11 |
undisclosed |
Undisclosed |
aHer2- (AL4c-LP13C)<sub>7.07</sub> Linker |
[344] | |
aHer2- (AL11a-LP1)4 |
aHer2- (AL6-LP1)<sub>3.6</sub> Payload |
Undisclosed |
aHer2- (AL7-LP2)<sub>3.83</sub> Linker |
[344] | |
aHer2- (AL11a-LP13)7.8 |
aHer2- (AL6-LP1)<sub>3.6</sub> Payload |
Undisclosed |
aHer2- (AL11a-LP13)<sub>7.8</sub> Linker |
[344] | |
aHer2- (AL11a-LP15)7.6 |
DX-8951 derivative (DXd) |
DNA topoisomerase 1 (TOP1) |
aHer2- (AL11a-LP15)<sub>7.6</sub> Linker |
[344] | |
aHer2- (BL1-LP1)7.7 |
aHer2- (AL6-LP1)<sub>3.6</sub> Payload |
Undisclosed |
aHer2- (BL1-LP1)<sub>7.7</sub> Linker |
[344] | |
aHer2- (BL1-LP13)14.88 |
aHer2- (AL6-LP1)<sub>3.6</sub> Payload |
Undisclosed |
aHer2- (BL1-LP13)<sub>14.88</sub> Linker |
[344] | |
aHer2- (BL3b-LP1)7.5 |
aHer2- (AL4c-LP1B)<sub>3.49</sub> Payload |
Undisclosed |
aHer2- (BL3b-LP1)<sub>7.5</sub> Linker |
[344] | |
aHer2 1- (Mc-GGFG-DXD)7.7 |
DX-8951 derivative (DXd) |
DNA topoisomerase 1 (TOP1) |
Mc-Gly-Gly-Phe-Gly |
[344] | |
aHer2 2- (Mc-GGFG-DXD)7.7 |
DX-8951 derivative (DXd) |
DNA topoisomerase 1 (TOP1) |
Mc-Gly-Gly-Phe-Gly |
[344] | |
aHer2 3- (Mc-GGFG-DXD)7.7 |
DX-8951 derivative (DXd) |
DNA topoisomerase 1 (TOP1) |
Mc-Gly-Gly-Phe-Gly |
[344] | |
aHer2 1- (Mc-GGFG-DXD)7.1 |
DX-8951 derivative (DXd) |
DNA topoisomerase 1 (TOP1) |
Mc-Gly-Gly-Phe-Gly |
[344] | |
aHer2 2- (Mc-GGFG-DXD)7.1 |
DX-8951 derivative (DXd) |
DNA topoisomerase 1 (TOP1) |
Mc-Gly-Gly-Phe-Gly |
[344] | |
aHer2 3- (Mc-GGFG-DXD)7.1 |
DX-8951 derivative (DXd) |
DNA topoisomerase 1 (TOP1) |
Mc-Gly-Gly-Phe-Gly |
[344] | |
AU2017341000B2 ADC (1) |
DX-8951 derivative (DXd) |
DNA topoisomerase 1 (TOP1) |
Mc-Gly-Gly-Phe-Gly |
[345] | |
TW202500135A-1 |
TW202500135A-1 payload |
Undisclosed |
Mc-Gly-Gly-Phe-Gly |
[346] | |
LN401-31-1 |
Tubulin inhibitor B |
Microtubule (MT) |
CN114106088A+ADC1+Linker |
[347] | |
LN401-31-2 |
Tubulin inhibitor B |
Microtubule (MT) |
CN114106088A+ADC2+Linker |
[347] | |
LN401-90-5 |
Tubulin inhibitor B |
Microtubule (MT) |
CN114106088A+ADC3+Linker |
[347] | |
LN401-90-6 |
Tubulin inhibitor B |
Microtubule (MT) |
CN114106088A+ADC4+Linker |
[347] | |
LN401-90-4 |
Tubulin inhibitor B |
Microtubule (MT) |
CN114106088A+ADC5+Linker |
[347] | |
US12195552B2 ADC1 |
Undisclosed |
Undisclosed |
Undisclosed |
[254] | |
US12195552B2 ADC2 |
Undisclosed |
Undisclosed |
Undisclosed |
[348] | |
US12195552B2 ADC3 |
Undisclosed |
Undisclosed |
Undisclosed |
[348] | |
US12195552B2 ADC4 |
Undisclosed |
Undisclosed |
Undisclosed |
[348] | |
US12195552B2 ADC5 |
Undisclosed |
Undisclosed |
Undisclosed |
[348] | |
US12195552B2 ADC6 |
Undisclosed |
Undisclosed |
Undisclosed |
[348] | |
US12195552B2 ADC7 |
Undisclosed |
Undisclosed |
Undisclosed |
[348] | |
US12195552B2 ADC8 |
Undisclosed |
Undisclosed |
Undisclosed |
[348] | |
US12195552B2 ADC9 |
Undisclosed |
Undisclosed |
Undisclosed |
[348] | |
US12195552B2 ADC10 |
Undisclosed |
Undisclosed |
Undisclosed |
[348] | |
US12195552B2 ADC11 |
Undisclosed |
Undisclosed |
Undisclosed |
[348] | |
US12195552B2 ADC12 |
Undisclosed |
Undisclosed |
Undisclosed |
[348] | |
US12195552B2 ADC13 |
Undisclosed |
Undisclosed |
Undisclosed |
[348] | |
US12195552B2 ADC14 |
Undisclosed |
Undisclosed |
Undisclosed |
[348] | |
US12195552B2 ADC15 |
Undisclosed |
Undisclosed |
Undisclosed |
[348] | |
US12195552B2 ADC16 |
Undisclosed |
Undisclosed |
Undisclosed |
[348] | |
US12195552B2 ADC17 |
Undisclosed |
Undisclosed |
Undisclosed |
[348] | |
US12195552B2 ADC18 |
Undisclosed |
Undisclosed |
Undisclosed |
[348] | |
US12195552B2 ADC19 |
Undisclosed |
Undisclosed |
Undisclosed |
[348] | |
US12195552B2 ADC20 |
Undisclosed |
Undisclosed |
Undisclosed |
[348] | |
US12195552B2 ADC21 |
Undisclosed |
Undisclosed |
Undisclosed |
[348] | |
US12195552B2 ADC22 |
Undisclosed |
Undisclosed |
Undisclosed |
[348] | |
US12195552B2 ADC23 |
Undisclosed |
Undisclosed |
Undisclosed |
[348] | |
US12195552B2 ADC24 |
Undisclosed |
Undisclosed |
Undisclosed |
[348] | |
US12195552B2 ADC25 |
Undisclosed |
Undisclosed |
Undisclosed |
[348] | |
US12195552B2 ADC26 |
Undisclosed |
Undisclosed |
Undisclosed |
[348] | |
US12195552B2 ADC27 |
Undisclosed |
Undisclosed |
Undisclosed |
[348] | |
US12195552B2 ADC28 |
Undisclosed |
Undisclosed |
Undisclosed |
[348] | |
US12195552B2 ADC29 |
Undisclosed |
Undisclosed |
Undisclosed |
[348] | |
US12195552B2 ADC30 |
Undisclosed |
Undisclosed |
Undisclosed |
[348] | |
US12195552B2 ADC31 |
Undisclosed |
Undisclosed |
Undisclosed |
[348] | |
US12195552B2 ADC32 |
Undisclosed |
Undisclosed |
Undisclosed |
[348] | |
US12195552B2 ADC33 |
Undisclosed |
Undisclosed |
Undisclosed |
[348] | |
US12195552B2 ADC34 |
Undisclosed |
Undisclosed |
Undisclosed |
[348] | |
US12195552B2 ADC35 |
Undisclosed |
Undisclosed |
Undisclosed |
[348] | |
US12195552B2 ADC36 |
Undisclosed |
Undisclosed |
Undisclosed |
[348] | |
US12195552B2 ADC37 |
Undisclosed |
Undisclosed |
Undisclosed |
[348] | |
US12195552B2 ADC38 |
Undisclosed |
Undisclosed |
Undisclosed |
[348] | |
US12195552B2 ADC39 |
Undisclosed |
Undisclosed |
Undisclosed |
[348] | |
US12195552B2 ADC40 |
Undisclosed |
Undisclosed |
Undisclosed |
[348] | |
30kmPEG (SCAHer2 (1)xSCAHer2 (2))-2 (Val-Cit-PAB-DEA-SN38) |
Active metabolite of irinotecan SN38 |
DNA topoisomerase 1 (TOP1) |
Undisclosed |
[350] | |
30kmPEG (SCAHer2 (1)xSCAHer2 (2))-3 (Val-Cit-PAB-DEA-SN38) |
Active metabolite of irinotecan SN38 |
DNA topoisomerase 1 (TOP1) |
Undisclosed |
[350] | |
Anti-HER-N297Q-Ex18 |
Undisclosed |
Undisclosed |
Undisclosed |
[351] | |
Anti-HER-N297Q-Ex27 |
Undisclosed |
Undisclosed |
Undisclosed |
[351] | |
SG11202200215QA ADC1 |
Ceritinib |
Undisclosed |
SG11202200215QA ADC5 linker |
[352] | |
SG11202200215QA ADC2 |
MK4827 |
Undisclosed |
SG11202200215QA ADC5 linker |
[352] | |
SG11202200215QA ADC3 |
Active metabolite of irinotecan SN38 |
DNA topoisomerase 1 (TOP1) |
SG11202200215QA ADC3 linker |
[352] | |
SG11202200215QA ADC4 |
Exatecan |
DNA topoisomerase 1 (TOP1) |
SG11202200215QA ADC5 linker |
[352] | |
SG11202200215QA ADC5 |
DX-8951 derivative (DXd) |
DNA topoisomerase 1 (TOP1) |
SG11202200215QA ADC5 linker |
[352] | |
WO2021260582A1 ADC-1 |
Exatecan |
DNA topoisomerase 1 (TOP1) |
Mc-Gly-Gly-Phe-Gly |
[353] | |
Production of the antibody-drug conjugate (1) |
undisclosed |
Undisclosed |
Undisclosed |
[354] |
References
