General Information of This Antigen
Antigen ID
TAR0THKZD
Antigen Name
Receptor tyrosine-protein kinase erbB-2 (ERBB2)
Gene Name
ERBB2
Gene ID
2064
Synonym
HER2; MLN19; NEU; NGL; Metastatic lymph node gene 19 protein;Proto-oncogene Neu;Proto-oncogene c-ErbB-2;Tyrosine kinase-type cell surface receptor HER2;p185erbB2;CD_antigen=CD340
Sequence
MELAALCRWGLLLALLPPGAASTQVCTGTDMKLRLPASPETHLDMLRHLYQGCQVVQGNL
ELTYLPTNASLSFLQDIQEVQGYVLIAHNQVRQVPLQRLRIVRGTQLFEDNYALAVLDNG
DPLNNTTPVTGASPGGLRELQLRSLTEILKGGVLIQRNPQLCYQDTILWKDIFHKNNQLA
LTLIDTNRSRACHPCSPMCKGSRCWGESSEDCQSLTRTVCAGGCARCKGPLPTDCCHEQC
AAGCTGPKHSDCLACLHFNHSGICELHCPALVTYNTDTFESMPNPEGRYTFGASCVTACP
YNYLSTDVGSCTLVCPLHNQEVTAEDGTQRCEKCSKPCARVCYGLGMEHLREVRAVTSAN
IQEFAGCKKIFGSLAFLPESFDGDPASNTAPLQPEQLQVFETLEEITGYLYISAWPDSLP
DLSVFQNLQVIRGRILHNGAYSLTLQGLGISWLGLRSLRELGSGLALIHHNTHLCFVHTV
PWDQLFRNPHQALLHTANRPEDECVGEGLACHQLCARGHCWGPGPTQCVNCSQFLRGQEC
VEECRVLQGLPREYVNARHCLPCHPECQPQNGSVTCFGPEADQCVACAHYKDPPFCVARC
PSGVKPDLSYMPIWKFPDEEGACQPCPINCTHSCVDLDDKGCPAEQRASPLTSIISAVVG
ILLVVVLGVVFGILIKRRQQKIRKYTMRRLLQETELVEPLTPSGAMPNQAQMRILKETEL
RKVKVLGSGAFGTVYKGIWIPDGENVKIPVAIKVLRENTSPKANKEILDEAYVMAGVGSP
YVSRLLGICLTSTVQLVTQLMPYGCLLDHVRENRGRLGSQDLLNWCMQIAKGMSYLEDVR
LVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETEYHADGGKVPIKWMALESILRRRFT
HQSDVWSYGVTVWELMTFGAKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMIMVKCWM
IDSECRPRFRELVSEFSRMARDPQRFVVIQNEDLGPASPLDSTFYRSLLEDDDMGDLVDA
EEYLVPQQGFFCPDPAPGAGGMVHHRHRSSSTRSGGGDLTLGLEPSEEEAPRSPLAPSEG
AGSDVFDGDLGMGAAKGLQSLPTHDPSPLQRYSEDPTVPLPSETDGYVAPLTCSPQPEYV
NQPDVRPQPPSPREGPLPAARPAGATLERPKTLSPGKNGVVKDVFAFGGAVENPEYLTPQ
GGAAPQPHPPPAFSPAFDNLYYWDQDPPERGAPPSTFKGTPTAENPEYLGLDVPV

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Family
Tyr protein family
Function
Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and CLASP2, allowing its association with the cell membrane. In turn, membrane-bound APC allows the localization of MACF1 to the cell membrane, which is required for microtubule capture and stabilization.

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Uniprot Entry
ERBB2_HUMAN
HGNC ID
HGNC:3430
KEGG ID
hsa:2064
Each Antibody-drug Conjuate AND It's Component Related to This Antigen
Full List of The ADC Related to This Antigen
ADC Info ADC Name Payload Target Linker Ref
WO2024105205A1 11e-1015a
KSPI6-1
Undisclosed
Undisclosed
[1]
ADC Info ADC Name Payload Target Linker Ref
39860260 2Rs15d-H3KH6-MMAE
Monomethyl auristatin E
Microtubule (MT)
DBCO-PEG4-Val-Cit-PABC
[2]
4D5 HC A118C
ADC Info ADC Name Payload Target Linker Ref
CN106714844B ADC-101
PNU-159682
DNA topoisomerase 2-alpha (TOP2A)
CN106714844B-ADC-101-linker
[3]
CN106714844B ADC-103
PNU-159682
DNA topoisomerase 2-alpha (TOP2A)
CN106714844B-ADC-103-linker
[3]
CN106714844B ADC-111
PNU-159682
DNA topoisomerase 2-alpha (TOP2A)
Undisclosed
[3]
CN106714844B ADC-112
PNU-159682
DNA topoisomerase 2-alpha (TOP2A)
Undisclosed
[3]
CN106714844B ADC-119
PNU-159682
DNA topoisomerase 2-alpha (TOP2A)
CN106714844B-ADC-119-linker
[3]
CN106714844B ADC-131
PNU-159682
DNA topoisomerase 2-alpha (TOP2A)
Undisclosed
[3]
4D5 HC A140C
ADC Info ADC Name Payload Target Linker Ref
CN106714844B ADC-128
PNU-159682
DNA topoisomerase 2-alpha (TOP2A)
Undisclosed
[3]
4D5 LC A149C
ADC Info ADC Name Payload Target Linker Ref
CN106714844B ADC-129
PNU-159682
DNA topoisomerase 2-alpha (TOP2A)
Undisclosed
[3]
4D5 LC S121C
ADC Info ADC Name Payload Target Linker Ref
CN106714844B ADC-132
PNU-159682
DNA topoisomerase 2-alpha (TOP2A)
Undisclosed
[3]
4D5 LC V205C
ADC Info ADC Name Payload Target Linker Ref
CN106714844B ADC-130
PNU-159682
DNA topoisomerase 2-alpha (TOP2A)
Undisclosed
[3]
7.16.4_msIgG2a
ADC Info ADC Name Payload Target Linker Ref
EP4489789A1 7.16.4_msIgG2a Conjugate 4
Undisclosed
Undisclosed
Undisclosed
[4]
7C2 HC A118C
ADC Info ADC Name Payload Target Linker Ref
CN106714844B ADC-107
PNU-159682
DNA topoisomerase 2-alpha (TOP2A)
Undisclosed
[3]
CN106714844B ADC-114
PNU-159682
DNA topoisomerase 2-alpha (TOP2A)
Undisclosed
[3]
7C2 HC K118C
ADC Info ADC Name Payload Target Linker Ref
CN106714844B ADC-140
PNU-159682
DNA topoisomerase 2-alpha (TOP2A)
Ethylmaleimide linker
[3]
7C2 LC K149C
ADC Info ADC Name Payload Target Linker Ref
CN106714844B ADC-108
PNU-159682
DNA topoisomerase 2-alpha (TOP2A)
Undisclosed
[3]
CN106714844B ADC-109
PNU-159682
DNA topoisomerase 2-alpha (TOP2A)
CN106714844B-ADC-109-linker
[3]
CN106714844B ADC-116
PNU-159682
DNA topoisomerase 2-alpha (TOP2A)
Undisclosed
[3]
CN106714844B ADC-134
PNU-159682
DNA topoisomerase 2-alpha (TOP2A)
CN106714844B-ADC-134-linker
[3]
CN106714844B ADC-135
PNU-159682
DNA topoisomerase 2-alpha (TOP2A)
CN106714844B-ADC-135-linker
[3]
CN106714844B ADC-136
PNU-159682
DNA topoisomerase 2-alpha (TOP2A)
Undisclosed
[3]
CN106714844B ADC-137
PNU-159682
DNA topoisomerase 2-alpha (TOP2A)
Ethylmaleimide linker
[3]
CN106714844B ADC-138
PNU-159682
DNA topoisomerase 2-alpha (TOP2A)
Ethylmaleimide linker
[3]
Ab0001-LCCTL-HC
ADC Info ADC Name Payload Target Linker Ref
LC301-1-1 (2)
Dxd-1
Undisclosed
LA301-1-1 linker
[5]
LC301-1-1 (4)
Dxd-1
Undisclosed
LA301-1-1 linker
[5]
LC301-2-1 (2)
Dxd-1
Undisclosed
LA301-1-1 linker
[5]
LC301-2-1 (4)
Dxd-1
Undisclosed
LA301-1-1 linker
[5]
LC301-3-1 (4)
Dxd-1
Undisclosed
LA301-3-1 linker
[5]
LC301-4-1 (6)
Dxd-1
Undisclosed
LA301-4-1 linker
[5]
LC301-5-1 (8)
Dxd-1
Undisclosed
LA301-5-1 linker
[5]
LC302-1-1 (2)
Dxd-1
Undisclosed
LA302-1-1 linker
[5]
LC302-1-1 (4)
Dxd-1
Undisclosed
LA302-1-1 linker
[5]
LC302-1-4 (2)
Dxd-1
Undisclosed
LA302-1-4 linker
[5]
LC302-1-4 (4)
Dxd-1
Undisclosed
LA302-1-4 linker
[5]
LC302-2-1 (4)
Dxd-1
Undisclosed
LA302-2-1 linker
[5]
LC302-2-4 (4) 4
Dxd-1
Undisclosed
LA302-2-4 linker
[5]
LC302-3-1 (6)
Dxd-1
Undisclosed
LA302-3-1 linker
[5]
LC302-3-4 (6)
Dxd-1
Undisclosed
LA302-3-4 linker
[5]
LC302-4-1 (8)
Dxd-1
Undisclosed
LA302-3-1 linker
[5]
LC302-4-4 (8)
Dxd-1
Undisclosed
LA302-3-4 linker
[5]
ADAPT6-ABD
ADC Info ADC Name Payload Target Linker Ref
ADAPT6-ABD-mcDM1
Mertansine DM1
Microtubule (MT)
Maleimidocaproyl (Ser3-Gly)3
[6]
Anbenitamab
ADC Info ADC Name Payload Target Linker Ref
Anbenitamab-ADC-Tb3-1
Anbenitamab-ADC-Tb3-1 payload
Undisclosed
Anbenitamab-ADC-Tb3-1 linker
[7]
Anbenitamab-ADC-Tb3-2
Anbenitamab-ADC-Tb3-2 payload
Undisclosed
Anbenitamab-ADC-Tb3-2 linker
[7]
Anbenitamab-ADC-Tb3-3
Anbenitamab-ADC-Tb3-3 payload
Undisclosed
Anbenitamab-ADC-Tb3-3 linker
[7]
Anbenitamab-ADC-Tb3-4
Anbenitamab-ADC-Tb3-4 payload
Undisclosed
Anbenitamab-ADC-Tb3-4 linker
[7]
Anbenitamab-ADC-Tb3-5
Anbenitamab-ADC-Tb3-5 payload
Undisclosed
Anbenitamab-ADC-Tb3-5 linker
[7]
Anbenitamab-ADC-Tb3-6
Anbenitamab-ADC-Tb3-6 payload
Undisclosed
Anbenitamab-ADC-Tb3-6 linker
[7]
Anbenitamab-ADC-Tb3-7
Anbenitamab-ADC-Tb3-7 payload
Undisclosed
Anbenitamab-ADC-Tb3-7 linker
[7]
Anbenitamab-ADC-Tb3-8
Anbenitamab-ADC-Tb3-8 payload
Undisclosed
Anbenitamab-ADC-Tb3-8 linker
[7]
Anbenitamab-ADC-Tb3-9
Anbenitamab-ADC-Tb3-9 payload
Undisclosed
Anbenitamab-ADC-Tb3-9 linker
[7]
Anbenitamab-ADC-Tb3-10
Anbenitamab-ADC-Tb3-10 payload
Undisclosed
Anbenitamab-ADC-Tb3-10 linker
[7]
ADC Info ADC Name Payload Target Linker Ref
An2-anti-HER2-Doxetaxel
Docetaxel
Microtubule (MT)
Undisclosed
[8]
Anti-HER2 1-alpha-hydroxyvitamin-D5-HER-2 Anti-ody conjugate mAb
ADC Info ADC Name Payload Target Linker Ref
Alpha-hydroxyvitamin-D5-HER2 antibody conjugate
Vitamin D
Undisclosed
Sulfosuccinimidyl 6-4 azido nitrophenylamido hexanode (SANPAH)
[9]
anti-Her2 114 (H- (A114C)) and 183 (H- (kK183C)) mAb
ADC Info ADC Name Payload Target Linker Ref
H- (C)-#10
Undisclosed
Undisclosed
Undisclosed
[10]
CD33-11A1-v1417 (C)-#39
CD33-11A1-v1417 (C)-#39 Payload
Undisclosed
CD33-11A1-v1417 (C)-#39 Linker
[10]
Anti-HER2 7C2 mAb
ADC Info ADC Name Payload Target Linker Ref
HER2-5 ADC
GNE-987 (R)
Bromodomain-containing protein 4 (BRD4)
Dolaflexin polymer
[11]
Anti-HER2 antibody 20507
ADC Info ADC Name Payload Target Linker Ref
WO2015095301A2 ADC-28
WO2015095301A2 ADC-28 payload
Undisclosed
WO2015095301A2 ADC-28 linker
[12]
WO2015095301A2 ADC-29
WO2015095301A2 ADC-29 payload
Undisclosed
WO2015095301A2 ADC-29 linker
[12]
WO2015095301A2 ADC-30
WO2015095301A2 ADC-30 payload
Undisclosed
WO2015095301A2 ADC-30 linker
[12]
WO2015095301A2 ADC-31
WO2015095301A2 ADC-31 payload
Undisclosed
WO2015095301A2 ADC-31 linker
[12]
WO2015095301A2 ADC-32
WO2015095301A2 ADC-32 payload
Undisclosed
WO2015095301A2 ADC-32 linker
[12]
WO2015095301A2 ADC-33
WO2015095301A2 ADC-33 payload
Undisclosed
WO2015095301A2 ADC-33 linker
[12]
WO2015095301A2 ADC-34
WO2015095301A2 ADC-34 payload
Undisclosed
WO2015095301A2 ADC-34 linker
[12]
WO2015095301A2 ADC-35
WO2015095301A2 ADC-35 payload
Undisclosed
WO2015095301A2 ADC-35 linker
[12]
WO2015095301A2 ADC-36
WO2015095301A2 ADC-36 payload
Undisclosed
WO2015095301A2 ADC-36 linker
[12]
WO2015095301A2 ADC-37
WO2015095301A2 ADC-37 payload
Undisclosed
WO2015095301A2 ADC-37 linker
[12]
WO2015189791A1 ADC-27
WO2015189791A1 ADC-27 payload
Undisclosed
WO2015189791A1 ADC-27 linker
[13]
WO2015189791A1 ADC-28
WO2015189791A1 ADC-28 payload
Undisclosed
WO2015189791A1 ADC-28 linker
[13]
WO2015189791A1 ADC-29
WO2015189791A1 ADC-29 payload
Undisclosed
WO2015189791A1 ADC-29 linker
[13]
WO2015189791A1 ADC-30
WO2015189791A1 ADC-30 payload
Undisclosed
WO2015189791A1 ADC-30 linker
[13]
WO2015189791A1 ADC-31
WO2015189791A1 ADC-31 payload
Undisclosed
WO2015189791A1 ADC-31 linker
[13]
WO2015189791A1 ADC-32
WO2015189791A1 ADC-32 payload
Undisclosed
WO2015189791A1 ADC-32 linker
[13]
WO2015189791A1 ADC-33
WO2015189791A1 ADC-33 payload
Undisclosed
WO2015189791A1 ADC-33 linker
[13]
WO2015189791A1 ADC-34
WO2015189791A1 ADC-34 payload
Undisclosed
WO2015189791A1 ADC-34 linker
[13]
WO2015189791A1 ADC-35
WO2015189791A1 ADC-35 payload
Undisclosed
WO2015189791A1 ADC-35 linker
[13]
WO2015189791A1 ADC-36
WO2015189791A1 ADC-36 payload
Undisclosed
WO2015189791A1 ADC-36 linker
[13]
WO2015189791A1 ADC-37
WO2015189791A1 ADC-37 payload
Undisclosed
WO2015189791A1 ADC-37 linker
[13]
WO2015189791A1 ADC-40
WO2015189791A1 ADC-40 payload
Undisclosed
WO2015189791A1 ADC-40 linker
[13]
WO2015189791A1 ADC-61
WO2015189791A1 ADC-61 payload
Undisclosed
WO2015189791A1 ADC-61 linker
[13]
WO2015189791A1 ADC-63
WO2015189791A1 ADC-63 payload
Undisclosed
WO2015189791A1 ADC-63 linker
[13]
WO2015189791A1 ADC-64
WO2015189791A1 ADC-64 payload
Undisclosed
WO2015189791A1 ADC-64 linker
[13]
Anti-HER2 antibody 2H9-A121C
ADC Info ADC Name Payload Target Linker Ref
2H9-A121C-BMPEO-DM1
Maytansinoid DM1
Microtubule (MT)
2H9-A121C-BMPEO-DM1 linker
[14]
anti-HER2 antibody mAb-1
ADC Info ADC Name Payload Target Linker Ref
WO2023232144A1ADC-1
WO2023232144A1, ADC-1, Payload
Microtubule (MT)
WO2023232144A1, ADC-1, linker
[15]
WO2023232144A1ADC-2
WO2023232144A1, ADC-2, Payload
DNA topoisomerase I (TOP1)
WO2023232144A1, ADC-2, linker
[15]
Anti-HER2 DVD-Fab
ADC Info ADC Name Payload Target Linker Ref
Anti-HER2 DVD-Fab_MMAF
Monomethyl auristatin F
Microtubule (MT)
Dibromomaleimide-PEG4
[16]
Anti-HER2 DVD-Fab-h38c2-K99C
ADC Info ADC Name Payload Target Linker Ref
Anti-HER2 DVD-Fab-h38c2-K99C_MMAF
Monomethyl auristatin F
Microtubule (MT)
Dibromomaleimide-PEG4
[16]
Anti-HER2 DVD-IgG1
ADC Info ADC Name Payload Target Linker Ref
Anti-HER2 DVD-IgG1_MMAF
Monomethyl auristatin F
Microtubule (MT)
Dibromomaleimide-PEG4
[16]
Anti-HER2 DVD-IgG1-Tiancimycin
Tiancimycin
Microtubule (MT)
DVD-PEG4-Triazol
[17]
Anti-HER2 DVD-IgG1-H38c2-K99C
ADC Info ADC Name Payload Target Linker Ref
Anti-HER2 DVD-IgG1-h38c2-K99C_MMAF
Monomethyl auristatin F
Microtubule (MT)
Dibromomaleimide-PEG4
[16]
Anti-HER2 DVD-IgG1-h38c2-K99C Fluorescein
Fluorescein derivative
Undisclosed
MS-PODA
[16]
Anti-HER2 DVD-IgG1-h38c2-K99C TAMTA 3
5(6)-Carboxytetramethylrhodamine
Undisclosed
Dibromomaleimide-PEG3
[16]
Anti-HER2 DVD-IgG1-h38c2-K99C TAMTA 2
5(6)-Carboxytetramethylrhodamine
Undisclosed
Monobromomaleimide-PEG3
[16]
Anti-HER2 DVD-IgG1-h38c2-K99C TAMTA 1
5(6)-Carboxytetramethylrhodamine
Undisclosed
Mal-PEG3
[16]
Anti-HER2 Fab
ADC Info ADC Name Payload Target Linker Ref
Fab-SN38
Active metabolite of irinotecan SN38
DNA topoisomerase 1 (TOP1)
LPETGGG-PEG3-Azide BCN-AVC
[18]
Anti-HER2 IgG1(GH2-20)
ADC Info ADC Name Payload Target Linker Ref
IgG1 (GH2-20)-vc-MMAE
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
[19]
Anti-HER2 IgG1(GH2-20) scFv
ADC Info ADC Name Payload Target Linker Ref
ScFv(GH2-20)-PE38KDEL
Pseudomonas exotoxin PE38
Eukaryotic elongation factor 2 kinase (EEF2K)
Undisclosed
[19]
Anti-HER2 IgG1(GH2-20)-AL1
ADC Info ADC Name Payload Target Linker Ref
IgG1 (GH2-20)-AL1-MMAE
Monomethyl auristatin E
Microtubule (MT)
Undisclosed
[19]
Anti-HER2 IgG1(GH2-61)
ADC Info ADC Name Payload Target Linker Ref
IgG1 (GH2-61)-vc-MMAE
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
[19]
Anti-HER2 IgG1(GH2-61) scFv
ADC Info ADC Name Payload Target Linker Ref
ScFv(GH2-61)-PE38KDEL
Pseudomonas exotoxin PE38
Eukaryotic elongation factor 2 kinase (EEF2K)
Undisclosed
[19]
Anti-HER2 IgG1(GH2-61)-AL1
ADC Info ADC Name Payload Target Linker Ref
IgG1 (GH2-61)-AL1-MMAE
Monomethyl auristatin E
Microtubule (MT)
Undisclosed
[19]
Anti-HER2 IgG1(GH2-75)
ADC Info ADC Name Payload Target Linker Ref
IgG1 (GH2-75)-vc-MMAE
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
[19]
Anti-HER2 IgG1(GH2-75) scFv
ADC Info ADC Name Payload Target Linker Ref
ScFv(GH2-75)-PE38KDEL
Pseudomonas exotoxin PE38
Eukaryotic elongation factor 2 kinase (EEF2K)
Undisclosed
[19]
Anti-HER2 IgG1(GH2-75)-AL1
ADC Info ADC Name Payload Target Linker Ref
IgG1 (GH2-75)-AL1-MMAE
Monomethyl auristatin E
Microtubule (MT)
Undisclosed
[19]
Anti-HER2 IgG1(H32)
ADC Info ADC Name Payload Target Linker Ref
IgG1 (H32)-vc-MMAE
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
[19]
Anti-HER2 IgG1(H32) scFv
ADC Info ADC Name Payload Target Linker Ref
ScFv(H32)-PE38KDEL
Pseudomonas exotoxin PE38
Eukaryotic elongation factor 2 kinase (EEF2K)
Undisclosed
[19]
Anti-HER2 IgG1(H32)-AL1
ADC Info ADC Name Payload Target Linker Ref
IgG1 (H32)-AL1-MMAE
Monomethyl auristatin E
Microtubule (MT)
Undisclosed
[19]
Anti-HER2 mAb
ADC Info ADC Name Payload Target Linker Ref
ADC2202
Undisclosed
Undisclosed
Undisclosed
[20]
Anti-HER2 ADC 12-3.1
Anti-HER2 ADC 12-3 payload
Undisclosed
Anti-HER2 ADC 12-3 linker
[21]
Alpha-HER2-Duo 405
Duocarmycin 405
Human Deoxyribonucleic acid (hDNA)
Undisclosed
[21]
Anti-HER2 ADC 2-7
Anti-HER2 ADC 2-7 payload
Undisclosed
Anti-HER2 ADC 2-7 linker
[21]
Anti-HER2 ADC 3-4
Anti-HER2 ADC 3-4 payload
Undisclosed
Anti-HER2 ADC 3-4 linker
[21]
Anti-HER2 ADC 4-3
Anti-HER2 ADC 4-3 payload
Undisclosed
Anti-HER2 ADC 4-3 linker
[21]
Anti-HER2 ADC 5-3
Anti-HER2 ADC 5-3 payload
Undisclosed
Anti-HER2 ADC 5-3 linker
[21]
Anti-HER2 ADC 6-2
Anti-HER2 ADC 6-2 payload
Undisclosed
Anti-HER2 ADC 6-2 linker
[21]
Anti-HER2 ADC 7-1
Anti-HER2 ADC 7-1 payload
Undisclosed
Anti-HER2 ADC 7-1 linker
[21]
Anti-HER2 ADC 8-5
Anti-HER2 ADC 8-5 payload
Undisclosed
Anti-HER2 ADC 8-5 linker
[21]
Anti-HER2 ADC 9-4
Anti-HER2 ADC 9-4 payload
Undisclosed
Anti-HER2 ADC 9-4 linker
[21]
Anti-HER2 ADC 10-1
Anti-HER2 ADC 10-1 payload
Undisclosed
Anti-HER2 ADC 10-1 linker
[21]
Anti-HER2 ADC 11-5
Anti-HER2 ADC 11-5 payload
Undisclosed
Anti-HER2 ADC 11-5 linker
[21]
Anti-HER2 ADC 12-3.2
Anti-HER2 ADC 12-3 payload
Undisclosed
Anti-HER2 ADC 12-3 linker
[21]
Anti-HER2 ADC 13-7
Anti-HER2 ADC 13-7 payload
Undisclosed
Anti-HER2 ADC 13-7 linker
[21]
Anti-HER2 ADC 14-5
Anti-HER2 ADC 14-5 payload
Undisclosed
Anti-HER2 ADC 14-5 linker
[21]
Anti-HER2 ADC 15-5
Anti-HER2 ADC 15-5 payload
Undisclosed
Anti-HER2 ADC 15-5 linker
[21]
Anti-HER2 ADC 16-5
Anti-HER2 ADC 16-5 payload
Undisclosed
Anti-HER2 ADC 16-5 linker
[21]
Anti-HER2 ADC 17-2
Anti-HER2 ADC 17-2 payload
Undisclosed
Anti-HER2 ADC 17-2 linker
[21]
Anti-HER2 ADC 18-3
Anti-HER2 ADC 18-3 payload
Undisclosed
Anti-HER2 ADC 18-3 linker
[21]
Anti-HER2 ADC 19-5
Anti-HER2 ADC 19-5 payload
Undisclosed
Anti-HER2 ADC 19-5 linker
[21]
Anti-HER2 ADC 20-5
Anti-HER2 ADC 20-5 payload
Undisclosed
Anti-HER2 ADC 20-5 linker
[21]
Anti-HER2 ADC 21-5
Anti-HER2 ADC 21-5 payload
Undisclosed
Anti-HER2 ADC 21-5 linker
[21]
HER2-HC-H-SS-PBD
SG2000
Human Deoxyribonucleic acid (hDNA)
H-disulfide linker
[22]
HER2-LC-H-SS-PBD
SG2000
Human Deoxyribonucleic acid (hDNA)
H-disulfide linker
[22]
HER2-HC-Me-SS-PBD
SG2000
Human Deoxyribonucleic acid (hDNA)
Me-disulfide linker
[22]
HER2-LC-Me-SS-PBD
SG2000
Human Deoxyribonucleic acid (hDNA)
Me-disulfide linker
[22]
Anti-HER2 mAb-Compound 9
Mertansine DM1
Microtubule (MT)
Anti-HER2 mAb-Compound 9 linker
[23]
Anti-HER2 mAb-Compound 17
Mertansine DM4
Microtubule (MT)
Anti-HER2 mAb-Compound 17 linker
[23]
Anti-HER2 mAb-Compound 25
Monomethyl auristatin E
Microtubule (MT)
Anti-HER2 mAb-Compound 25 linker
[23]
Anti-HER2 mAb-Compound 31
Auristatin 0101
Microtubule (MT)
Anti-HER2 mAb-Compound 31 linker
[23]
Anti-HER2 mAb-Compound 36
Monomethyl auristatin E
Microtubule (MT)
Anti-HER2 mAb-Compound 36 linker
[23]
Anti-HER2 mAb-Compound 43
PBD dimer
Human Deoxyribonucleic acid (hDNA)
Anti-HER2 mAb-Compound 43 linker
[23]
Anti-HER2 mAb-Compound 49
PBD dimer
Human Deoxyribonucleic acid (hDNA)
Anti-HER2 mAb-Compound 49 linker
[23]
Anti-HER2 mAb-Compound 55
Mertansine DM1
Microtubule (MT)
Anti-HER2 mAb-Compound 55 linker
[23]
Anti-HER2 mAb-Compound 59
Mertansine DM4
Microtubule (MT)
Anti-HER2 mAb-Compound 59 linker
[23]
Anti-HER2 mAb-Compound 64
Monomethyl auristatin E
Microtubule (MT)
Anti-HER2 mAb-Compound 64 linker
[23]
Anti-HER2 mAb-Compound 69
Monomethyl auristatin E
Microtubule (MT)
Anti-HER2 mAb-Compound 69 linker
[23]
Anti-HER2 mAb-Compound 74
PBD dimer
Human Deoxyribonucleic acid (hDNA)
Anti-HER2 mAb-Compound 74 linker
[23]
Anti-HER2 mAb-Compound 75
Monomethyl auristatin E
Microtubule (MT)
Anti-HER2 mAb-Compound 75 linker
[23]
Anti-HER2 mAb-Compound 76
Monomethyl auristatin E
Microtubule (MT)
Anti-HER2 mAb-Compound 76 linker
[23]
Anti-HER2 mAb-Compound 77
Mertansine DM1
Microtubule (MT)
Anti-HER2 mAb-Compound 77 linker
[23]
Anti-HER2 mAb-Compound 78
Auristatin 0101
Microtubule (MT)
Anti-HER2 mAb-Compound 78 linker
[23]
Anti-HER2 mAb-Compound 79
Auristatin 0101
Microtubule (MT)
Anti-HER2 mAb-Compound 79 linker
[23]
Anti-HER2 mAb-Compound 80
Mertansine DM4
Microtubule (MT)
Anti-HER2 mAb-Compound 80 linker
[23]
CN110997010A ADC-1
CN110997010A ADC-1 payload
Undisclosed
CN110997010A ADC-1 linker
[24]
CN110997010A ADC-2
CN110997010A ADC-2 payload
Undisclosed
CN110997010A ADC-2 linker
[24]
CN110997010A ADC-3
CN110997010A ADC-3 payload
Undisclosed
CN110997010A ADC-3 linker
[24]
CN110997010A ADC-4
CN110997010A ADC-4 payload
Undisclosed
CN110997010A ADC-4 linker
[24]
CN110997010A ADC-5
CN110997010A ADC-5 payload
Undisclosed
CN110997010A ADC-5 linker
[24]
CN110997010A ADC-6
CN110997010A ADC-6 payload
Undisclosed
CN110997010A ADC-6 linker
[24]
CN110997010A ADC-7
CN110997010A ADC-7 payload
Undisclosed
CN110997010A ADC-7 linker
[24]
CN110997010A ADC-8
CN110997010A ADC-8 payload
Undisclosed
CN110997010A ADC-8 linker
[24]
CN110997010A ADC-9
Undisclosed
Undisclosed
CN110997010A ADC-9 linker
[24]
CN110997010A ADC-10
Undisclosed
Undisclosed
CN110997010A ADC-10 linker
[24]
CN110997010A ADC-11
Undisclosed
Undisclosed
CN110997010A ADC-11 linker
[24]
CN110997010A ADC-12
Undisclosed
Undisclosed
CN110997010A ADC-12 linker
[24]
CN110997010A ADC-13
Undisclosed
Undisclosed
CN110997010A ADC-13 linker
[24]
CN110997010A ADC-14
Undisclosed
Undisclosed
CN110997010A ADC-14 linker
[24]
CN110997010A ADC-15
Undisclosed
Undisclosed
CN110997010A ADC-15 linker
[24]
CN110997010A ADC-16
Undisclosed
Undisclosed
CN110997010A ADC-16 linker
[24]
CN110997010A ADC-17
Undisclosed
Undisclosed
CN110997010A ADC-17 linker
[24]
CN110997010A ADC-18
Undisclosed
Undisclosed
CN110997010A ADC-18 linker
[24]
CN110997010A ADC-19
Undisclosed
Undisclosed
CN110997010A ADC-19 linker
[24]
CN110997010A ADC-20
Undisclosed
Undisclosed
CN110997010A ADC-20 linker
[24]
CN110997010A ADC-21
Undisclosed
Undisclosed
CN110997010A ADC-21 linker
[24]
CN110997010A ADC-22
Undisclosed
Undisclosed
CN110997010A ADC-22 linker
[24]
CN110997010A ADC-23
Undisclosed
Undisclosed
CN110997010A ADC-1 linker
[24]
CN110997010A ADC-24
Undisclosed
Undisclosed
CN110997010A ADC-3 linker
[24]
CN110997010A ADC-25
Undisclosed
Undisclosed
CN110997010A ADC-3 linker
[24]
CN110997010A ADC-26
Undisclosed
Undisclosed
CN110997010A ADC-26 linker
[24]
CN110997010A ADC-27
Undisclosed
Undisclosed
CN110997010A ADC-5 linker
[24]
CN110997010A ADC-28
Undisclosed
Undisclosed
CN110997010A ADC-6 linker
[24]
CN110997010A ADC-29
Undisclosed
Undisclosed
CN110997010A ADC-7 linker
[24]
CN110997010A ADC-30
Undisclosed
Undisclosed
CN110997010A ADC-8 linker
[24]
CN110997010A ADC-31
Undisclosed
Undisclosed
CN110997010A ADC-31 linker
[24]
CN110997010A ADC-32
Undisclosed
Undisclosed
CN110997010A ADC-32 linker
[24]
CN110997010A ADC-33
Undisclosed
Undisclosed
CN110997010A ADC-33 linker
[24]
CN110997010A ADC-34
Undisclosed
Undisclosed
CN110997010A ADC-34 linker
[24]
Anti-HER2 mAb A114N
ADC Info ADC Name Payload Target Linker Ref
A114N-Mc-Val-Cit-PABC-MMAE
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
[25]
Anti-HER2 mAb A114N NNAS
ADC Info ADC Name Payload Target Linker Ref
A114N NNAS-Mc-Val-Cit-PABC-MMAE
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
[25]
Anti-HER2 mAb glutamine 295 (Q295)
ADC Info ADC Name Payload Target Linker Ref
VCit ADC 3a
Monomethyl auristatin F
Microtubule (MT)
DBCO-PEG-VCit-PABC
[26]
EVCit ADC 3c
Monomethyl auristatin F
Microtubule (MT)
DBCO-PEG-EVCit-PABC
[26]
Anti-HER2 mAb H-1
ADC Info ADC Name Payload Target Linker Ref
H-1-vcMMAE
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
[27]
Anti-HER2 mAb H-3
ADC Info ADC Name Payload Target Linker Ref
H-3-vcMMAE
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
[27]
Anti-HER2 mAb H-4
ADC Info ADC Name Payload Target Linker Ref
H-4-vcMMAE
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
[27]
Anti-HER2 mAb H32
ADC Info ADC Name Payload Target Linker Ref
H32-DM1_3.0
Mertansine DM1
Microtubule (MT)
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
[28]
H32-DM1_3.3
Mertansine DM1
Microtubule (MT)
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
[28]
H32-DM1_3.7
Mertansine DM1
Microtubule (MT)
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
[28]
H32-DM1_3.8
Mertansine DM1
Microtubule (MT)
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
[28]
H32-VCMMAE_2.1
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
[28]
H32-VCMMAE_3.2
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
[28]
H32-VCMMAE_3.8
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
[28]
H32-VCMMAE_6.6
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
[28]
Anti-HER2 mAb NNAS
ADC Info ADC Name Payload Target Linker Ref
NNAS-Mc-Val-Cit-PABC-MMAE
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
[25]
Anti-HER2 mAb S298N/T299A/Y300S
ADC Info ADC Name Payload Target Linker Ref
HER2 S298N/T299A/Y300S-Mc-Val-Cit-PABC-MMAE
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
[25]
Anti-HER2 mAb WT
ADC Info ADC Name Payload Target Linker Ref
HER2 WT-Mc-Val-Cit-PABC-MMAE
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
[25]
Anti-HER-AO-Cys-MC-VC-PABC-MMAE
Monomethyl auristatin E
Microtubule (MT)
Anti-HER-AO-Cys-MC-VC-PABC-MMAE linker
[25]
Anti-HER-MC-VC-PABC-PEG8-Dol10
Anti-HER-MC-VC-PABC-PEG8-Dol10 payload
Undisclosed
Anti-HER-MC-VC-PABC-PEG8-Dol10 linker
[25]
Anti-HER-AO-Cys-MC-VC-PABC-PEG8-Dol10
Anti-HER-AO-Cys-MC-VC-PABC-PEG8-Dol10 payload
Undisclosed
Anti-HER-AO-Cys-MC-VC-PABC-PEG8-Dol10 linker
[25]
Anti-HER2 scFv-Fc (Ser396Sec)
ADC Info ADC Name Payload Target Linker Ref
Anti-HER2 scFv-Fc (Ser396Sec)-CN29
Monomethyl auristatin F derivative peptide (CN29)
Microtubule (MT)
Lodoacetamido-caproyl
[29]
Anti-Her2 WT
ADC Info ADC Name Payload Target Linker Ref
Anti-HER-MC-VC-FABC-MMAE
Monomethyl auristatin E
Microtubule (MT)
Aminooxy-Cys linker
[30]
AntiHER-AO-Cys-MC-VC-FABC-MMAE
Monomethyl auristatin E
Microtubule (MT)
Aminooxy-Cys linker
[30]
Anti-HER-MC-VC-FABC-FEG8-DollO
DollO
Undisclosed
Aminooxy-Cys linker
[30]
Anti-HER-AO-Cys-MC-VC-FABC-FEG8- DollO
DollO
Undisclosed
Aminooxy-Cys linker
[30]
Anti-HER2-D265C
ADC Info ADC Name Payload Target Linker Ref
Anti-HER2-D265C-30.2060
Amanitin 30.206
DNA-directed RNA polymerase II subunit RPB2 (POLR2B); DNA-directed RNA polymerase III subunit RPC7 (POLR3G)
Mc-Val-Ala-PABC
[31]
Anti-HER2-D265C-30.2115
Amanitin 30.2115
DNA-directed RNA polymerase II subunit RPB2 (POLR2B); DNA-directed RNA polymerase III subunit RPC7 (POLR3G)
Mc-Val-Ala-PABC
[31]
Anti-HER2-D265C-30.2347
Amanitin 30.2347
DNA-directed RNA polymerase II subunit RPB2 (POLR2B); DNA-directed RNA polymerase III subunit RPC7 (POLR3G)
Mc-Val-Ala-PABC
[31]
Anti-HER2-D265C-30.1699
Amanitin 30.1699
DNA-directed RNA polymerase II subunit RPB2 (POLR2B); DNA-directed RNA polymerase III subunit RPC7 (POLR3G)
Mc-Val-Ala-PABC
[31]
Anti-HER2-D265C-30.2371
Amanitin 30.2371
DNA-directed RNA polymerase II subunit RPB2 (POLR2B); DNA-directed RNA polymerase III subunit RPC7 (POLR3G)
Mc-Val-Ala-PABC
[31]
Anti-HER2-D265C-30.0880
Amanitin 30.088
DNA-directed RNA polymerase II subunit RPB2 (POLR2B); DNA-directed RNA polymerase III subunit RPC7 (POLR3G)
Maleimido-caproyl
[31]
Anti-HER2-D265C-30.2867
Amanitin 30.2867
DNA-directed RNA polymerase II subunit RPB2 (POLR2B); DNA-directed RNA polymerase III subunit RPC7 (POLR3G)
Maleimido-caproyl
[31]
Anti-HER2/neu mAb 4D5
ADC Info ADC Name Payload Target Linker Ref
4D5-AF (CUAAC)
Auristatin F
Microtubule (MT)
N6-(2-azidoethoxy)carbonyl-L-lysine
[32]
Anti-Her2Fab
ADC Info ADC Name Payload Target Linker Ref
TWI852077B-J8
Undisclosed
Undisclosed
Undisclosed
[33]
TWI852077B-J13
Undisclosed
Undisclosed
Undisclosed
[33]
Anti-Her2Fab'
ADC Info ADC Name Payload Target Linker Ref
TWI852077B-J6
Monomethyl auristatin E
Microtubule (MT)
TWI852077B-C1-linker
[33]
Anti-human HER2 mAb
ADC Info ADC Name Payload Target Linker Ref
HER2-EC4 DAR7.8
NAMPT inhibitor 5
Nicotinamide phosphoribosyltransferase (NAMPT)
Open-chain glycine maleimide
[34]
HER2-EC5
NAMPT inhibitor 6
Nicotinamide phosphoribosyltransferase (NAMPT)
Open-chain glycine maleimide-PEG
[34]
HER2-EC4 DAR2.7
NAMPT inhibitor 5
Nicotinamide phosphoribosyltransferase (NAMPT)
Open-chain glycine maleimide
[34]
HER2-EC3
NAMPT inhibitor 4
Nicotinamide phosphoribosyltransferase (NAMPT)
Mc-Val-Ala
[34]
HER2-EC1
NAMPT inhibitor 4
Nicotinamide phosphoribosyltransferase (NAMPT)
Maleimido-caproyl
[34]
Anvatabart
ADC Info ADC Name Payload Target Linker Ref
Anvatabart pactil
Undisclosed
Undisclosed
Undisclosed
[35]
Az-LacNAc-Tras Ab7
ADC Info ADC Name Payload Target Linker Ref
HER2-gsADC-41
Monomethyl auristatin E
Microtubule (MT)
Bicyclononyne derivative 6e
[36]
HER2-gsADC-42
Monomethyl auristatin E
Microtubule (MT)
PEGylation linker 6l
[36]
HER2-gsADC-43
Monomethyl auristatin E
Microtubule (MT)
PEGylation linker 6m
[36]
HER2-gsADC-44
Monomethyl auristatin E
Microtubule (MT)
Noncleavable linker 6s
[36]
HER2-gsADC-45
Monomethyl auristatin E
Microtubule (MT)
Noncleavable linker 6t
[36]
Azido-tagged trastuzumab (Ab2)
ADC Info ADC Name Payload Target Linker Ref
HER2-gsADC-5
Monomethyl auristatin E
Microtubule (MT)
Azadibenzocylooctyne-amine derivative 6d
[36]
HER2-gsADC-6
Monomethyl auristatin E
Microtubule (MT)
Bicyclononyne derivative 6e
[36]
HER2-gsADC-7
Monomethyl auristatin E
Microtubule (MT)
PEGylation linker 6m
[36]
HER2-gsADC-8
Monomethyl auristatin E
Microtubule (MT)
Glycosyl PEGylation linker 6r
[36]
Azido-tagged trastuzumab (Ab3)
ADC Info ADC Name Payload Target Linker Ref
HER2-gsADC-9
Monomethyl auristatin E
Microtubule (MT)
Linear alkyne 6f
[36]
HER2-gsADC-10
Monomethyl auristatin E
Microtubule (MT)
PEGylation linker 6g
[36]
HER2-gsADC-11
Monomethyl auristatin E
Microtubule (MT)
PEGylation linker 6h
[36]
HER2-gsADC-12
Monomethyl auristatin E
Microtubule (MT)
PEGylation linker 6i
[36]
HER2-gsADC-13
Monomethyl auristatin E
Microtubule (MT)
PEGylation linker 6j
[36]
HER2-gsADC-14
Monomethyl auristatin E
Microtubule (MT)
PEGylation linker 6k
[36]
HER2-gsADC-15
Monomethyl auristatin E
Microtubule (MT)
PEGylation linker 6l
[36]
HER2-gsADC-16
Monomethyl auristatin E
Microtubule (MT)
PEGylation linker 6m
[36]
HER2-gsADC-17
Monomethyl auristatin E
Microtubule (MT)
Noncleavable linker 6t
[36]
Azido-tagged trastuzumab (Ab5)
ADC Info ADC Name Payload Target Linker Ref
HER2-gsADC-22
Monomethyl auristatin E
Microtubule (MT)
Linear alkyne 6f
[36]
HER2-gsADC-23
Monomethyl auristatin E
Microtubule (MT)
PEGylation linker 6g
[36]
HER2-gsADC-24
Monomethyl auristatin E
Microtubule (MT)
PEGylation linker 6h
[36]
HER2-gsADC-25
Monomethyl auristatin E
Microtubule (MT)
PEGylation linker 6i
[36]
HER2-gsADC-26
Monomethyl auristatin E
Microtubule (MT)
PEGylation linker 6j
[36]
HER2-gsADC-27
Monomethyl auristatin E
Microtubule (MT)
PEGylation linker 6k
[36]
HER2-gsADC-28
Monomethyl auristatin E
Microtubule (MT)
PEGylation linker 6l
[36]
HER2-gsADC-29
Monomethyl auristatin E
Microtubule (MT)
PEGylation linker 6m
[36]
HER2-gsADC-30
Monomethyl auristatin E
Microtubule (MT)
Glycosyl PEGylation linker 6o
[36]
HER2-gsADC-31
Monomethyl auristatin E
Microtubule (MT)
Glycosyl PEGylation linker 6p
[36]
HER2-gsADC-32
Monomethyl auristatin E
Microtubule (MT)
Glycosyl PEGylation linker 6q
[36]
HER2-gsADC-33
Monomethyl auristatin E
Microtubule (MT)
Glycosyl PEGylation linker 6r
[36]
Azido-tagged trastuzumab (Ab6)
ADC Info ADC Name Payload Target Linker Ref
HER2-gsADC-34
Monomethyl auristatin E
Microtubule (MT)
Linear alkyne 6f
[36]
HER2-gsADC-35
Monomethyl auristatin E
Microtubule (MT)
PEGylation linker 6g
[36]
HER2-gsADC-36
Monomethyl auristatin E
Microtubule (MT)
PEGylation linker 6h
[36]
HER2-gsADC-37
Monomethyl auristatin E
Microtubule (MT)
PEGylation linker 6i
[36]
HER2-gsADC-38
Monomethyl auristatin E
Microtubule (MT)
PEGylation linker 6j
[36]
HER2-gsADC-39
Monomethyl auristatin E
Microtubule (MT)
PEGylation linker 6k
[36]
HER2-gsADC-40
Monomethyl auristatin E
Microtubule (MT)
PEGylation linker 6l
[36]
ADC Info ADC Name Payload Target Linker Ref
B2-MMAE
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
[37]
BA-130-00-01
ADC Info ADC Name Payload Target Linker Ref
LC A032D/HC
LC A032D/HC payload
Undisclosed
LC A032D/HC linker
[38]
BA-130-03-02
ADC Info ADC Name Payload Target Linker Ref
LC A032D/HC Y052K
LC A032D/HC Y052K payload
Undisclosed
LC A032D/HC Y052K linker
[38]
BA-130-03-05
ADC Info ADC Name Payload Target Linker Ref
LC A032D/HC G056K
LC A032D/HC G056K payload
Undisclosed
LC A032D/HC G056K linker
[38]
BA-130-03-06
ADC Info ADC Name Payload Target Linker Ref
LC A032D/HC T058D
LC A032D/HC T058D payload
Undisclosed
LC A032D/HC T058D linker
[38]
BA-130-03-07
ADC Info ADC Name Payload Target Linker Ref
LC A032D/HC A106E
LC A032D/HC A106E payload
Undisclosed
LC A032D/HC A106E linker
[38]
BA-130-03-08
ADC Info ADC Name Payload Target Linker Ref
LC A032D/HC S119E
LC A032D/HC S119E payload
Undisclosed
LC A032D/HC S119E linker
[38]
ADC Info ADC Name Payload Target Linker Ref
HER2 KSP-ADC 1.1
Pyrrole based kinesin spindle protein inhibitor
Kinesin-like protein KIF11 (KIF11)
Kinesin spindle protein inhibitor (KSPi)-ADC linker 1
[39]
HER2 KSP-ADC 1.2
Pyrrole based kinesin spindle protein inhibitor
Kinesin-like protein KIF11 (KIF11)
Kinesin spindle protein inhibitor (KSPi)-ADC linker 2
[39]
HER2 KSP-ADC 1.3
Pyrrole based kinesin spindle protein inhibitor
Kinesin-like protein KIF11 (KIF11)
Kinesin spindle protein inhibitor (KSPi)-ADC linker 3
[39]
HER2 KSP-ADC 1.4
Pyrrole based kinesin spindle protein inhibitor
Kinesin-like protein KIF11 (KIF11)
Kinesin spindle protein inhibitor (KSPi)-ADC linker 4
[39]
HER2 KSP-ADC 2.1
Pyrrole based kinesin spindle protein inhibitor
Kinesin-like protein KIF11 (KIF11)
Kinesin spindle protein inhibitor (KSPi)-ADC linker 5
[39]
HER2 KSP-ADC 2.2
Pyrrole based kinesin spindle protein inhibitor
Kinesin-like protein KIF11 (KIF11)
Kinesin spindle protein inhibitor (KSPi)-ADC linker 6
[39]
ADC Info ADC Name Payload Target Linker Ref
BB02E-MMAE
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
[40]
ADC Info ADC Name Payload Target Linker Ref
BB03E-MMAE
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
[40]
ADC Info ADC Name Payload Target Linker Ref
BB03E-A-MMAE
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
[40]
ADC Info ADC Name Payload Target Linker Ref
BB04E-MMAE
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
[40]
ADC Info ADC Name Payload Target Linker Ref
BB05E-MMAE
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
[40]
BCN-trastuzumab tras-v1a-145
ADC Info ADC Name Payload Target Linker Ref
Trast-v1a-145-PF03
Undisclosed
Undisclosed
Undisclosed
[41]
Trast-v1a-145-PF09
Undisclosed
Undisclosed
Undisclosed
[41]
Trast-v1a-145-PF12
Undisclosed
Undisclosed
Undisclosed
[41]
Trast-v1a-145-PF13
Undisclosed
Undisclosed
Undisclosed
[41]
Trast-v1a-145-PF17
Undisclosed
Undisclosed
Undisclosed
[41]
Tras-v1a-145-PF19
Undisclosed
Undisclosed
Undisclosed
[41]
Trast-v1a-145-PF21
Undisclosed
Undisclosed
Undisclosed
[41]
bis-azido-trastuzumab tras-v1a
ADC Info ADC Name Payload Target Linker Ref
Tras-v1a-PF29
Undisclosed
Undisclosed
Undisclosed
[41]
bis-azido-trastuzumab trast-v1a
ADC Info ADC Name Payload Target Linker Ref
Trast-v1a-PF22
Undisclosed
Undisclosed
Undisclosed
[41]
Rit-v1a-145-PF22
Undisclosed
Undisclosed
Undisclosed
[41]
Trast-v1a-PF23
Undisclosed
Undisclosed
Undisclosed
[41]
Trast-v1a- (PF07)2
Undisclosed
Undisclosed
Undisclosed
[41]
Trast-v1a- (PF10)2
Undisclosed
Undisclosed
Undisclosed
[41]
Trast-v1a- (PF11)2
Undisclosed
Undisclosed
Undisclosed
[41]
Trast-v1a- (PF14)2
Undisclosed
Undisclosed
Undisclosed
[41]
Trast-v1a- (PF15)2
Undisclosed
Undisclosed
Undisclosed
[41]
Trast-v1a-145-PF27
Undisclosed
Undisclosed
Undisclosed
[41]
Trast-v1a- (PF20)2
Undisclosed
Undisclosed
Undisclosed
[41]
CHO-G2F-Tras (Ab4)
ADC Info ADC Name Payload Target Linker Ref
HER2-gsADC-18
Monomethyl auristatin E
Microtubule (MT)
ThioPz linker 6a
[36]
HER2-gsADC-19
Monomethyl auristatin E
Microtubule (MT)
2-Aminobenzamide oxime
[36]
HER2-gsADC-20
Monomethyl auristatin E
Microtubule (MT)
Hydroxylamine derivative 6c
[36]
HER2-gsADC-21
Monomethyl auristatin E
Microtubule (MT)
PEGylation linker 6n
[36]
CHO-S2G2F-Tras (Ab1)
ADC Info ADC Name Payload Target Linker Ref
HER2-gsADC-1
Monomethyl auristatin E
Microtubule (MT)
ThioPz linker 6a
[36]
HER2-gsADC-2
Monomethyl auristatin E
Microtubule (MT)
2-Aminobenzamide oxime
[36]
HER2-gsADC-3
Monomethyl auristatin E
Microtubule (MT)
Hydroxylamine derivative 6c
[36]
HER2-gsADC-4
Monomethyl auristatin E
Microtubule (MT)
PEGylation linker 6n
[36]
CN105828840B_ADC-102 antibody
ADC Info ADC Name Payload Target Linker Ref
CN105828840B ADC-102
CN105828840B_ADC-102 payload
Undisclosed
CN105828840B_ADC-102 linker
[42]
CN105828840B_ADC-103 antibody
ADC Info ADC Name Payload Target Linker Ref
CN105828840B ADC-103
CN105828840B_ADC-103 payload
Undisclosed
CN105828840B_ADC-103 linker
[42]
CN105828840B_ADC-105 antibody
ADC Info ADC Name Payload Target Linker Ref
CN105828840B ADC-105
CN105828840B_ADC-105 payload
Undisclosed
CN105828840B_ADC-105 linker
[42]
CN105828840B_ADC-106 antibody
ADC Info ADC Name Payload Target Linker Ref
CN105828840B ADC-106
CN105828840B_ADC-106 payload
Undisclosed
CN105828840B_ADC-106 linker
[42]
CN105828840B_ADC-107 antibody
ADC Info ADC Name Payload Target Linker Ref
CN105828840B ADC-107
CN105828840B_ADC-107 payload
Undisclosed
CN105828840B_ADC-107 linker
[42]
CN105828840B_ADC-109 antibody
ADC Info ADC Name Payload Target Linker Ref
CN105828840B ADC-109
CN105828840B_ADC-109 payload
Undisclosed
CN105828840B_ADC-109 linker
[42]
CN105828840B_ADC-112 antibody
ADC Info ADC Name Payload Target Linker Ref
CN105828840B ADC-112
CN105828840B_ADC-112 payload
Undisclosed
CN105828840B_ADC-112 linker
[42]
CN105828840B_ADC-113 antibody
ADC Info ADC Name Payload Target Linker Ref
CN105828840B ADC-113
CN105828840B_ADC-113 payload
Undisclosed
CN105828840B_ADC-113 linker
[42]
CN105828840B_ADC-114 antibody
ADC Info ADC Name Payload Target Linker Ref
CN105828840B ADC-114
CN105828840B_ADC-114 payload
Undisclosed
CN105828840B_ADC-114 linker
[42]
CN105828840B_ADC-117 antibody
ADC Info ADC Name Payload Target Linker Ref
CN105828840B ADC-117
CN105828840B_ADC-117 payload
Undisclosed
CN105828840B_ADC-117 linker
[42]
CN105828840B_ADC-118 antibody
ADC Info ADC Name Payload Target Linker Ref
CN105828840B ADC-118
CN105828840B_ADC-118 payload
Undisclosed
CN105828840B_ADC-118 linker
[42]
CN105828840B_ADC-119 antibody
ADC Info ADC Name Payload Target Linker Ref
CN105828840B ADC-119
CN105828840B_ADC-119 payload
Undisclosed
CN105828840B_ADC-119 linker
[42]
CN105828840B_ADC-121 antibody
ADC Info ADC Name Payload Target Linker Ref
CN105828840B ADC-121
CN105828840B_ADC-121 payload
Undisclosed
CN105828840B_ADC-121 linker
[42]
CN105828840B_ADC-123 antibody
ADC Info ADC Name Payload Target Linker Ref
CN105828840B ADC-123
CN105828840B_ADC-123 payload
Undisclosed
CN105828840B_ADC-123 linker
[42]
Coprelotamab
ADC Info ADC Name Payload Target Linker Ref
Coprelotamab-ADC-Tb3-1
Coprelotamab-ADC-Tb3-1 payload
Undisclosed
Coprelotamab-ADC-Tb3-1 linker
[7]
Coprelotamab-ADC-Tb3-2
Coprelotamab-ADC-Tb3-2 payload
Undisclosed
Coprelotamab-ADC-Tb3-2 linker
[7]
Coprelotamab-ADC-Tb3-3
Coprelotamab-ADC-Tb3-3 payload
Undisclosed
Coprelotamab-ADC-Tb3-3 linker
[7]
Coprelotamab-ADC-Tb3-4
Coprelotamab-ADC-Tb3-4 payload
Undisclosed
Coprelotamab-ADC-Tb3-4 linker
[7]
Coprelotamab-ADC-Tb3-5
Coprelotamab-ADC-Tb3-5 payload
Undisclosed
Coprelotamab-ADC-Tb3-5 linker
[7]
Coprelotamab-ADC-Tb3-6
Coprelotamab-ADC-Tb3-6 payload
Undisclosed
Coprelotamab-ADC-Tb3-6 linker
[7]
Coprelotamab-ADC-Tb3-7
Coprelotamab-ADC-Tb3-7 payload
Undisclosed
Coprelotamab-ADC-Tb3-7 linker
[7]
Coprelotamab-ADC-Tb3-8
Coprelotamab-ADC-Tb3-8 payload
Undisclosed
Coprelotamab-ADC-Tb3-8 linker
[7]
Coprelotamab-ADC-Tb3-9
Coprelotamab-ADC-Tb3-9 payload
Undisclosed
Coprelotamab-ADC-Tb3-9 linker
[7]
Coprelotamab-ADC-Tb3-10
Coprelotamab-ADC-Tb3-10 payload
Undisclosed
Coprelotamab-ADC-Tb3-10 linker
[7]
Cys-mutant trastuzumab
ADC Info ADC Name Payload Target Linker Ref
Cys-mutant trastuzumab-biotin
Biotin
Undisclosed
Undisclosed
[43]
degly-ISOmAb
ADC Info ADC Name Payload Target Linker Ref
Degly-ISOmAb-1-mc-vc-PAB-MMAE
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
[44]
degly-mAb1
ADC Info ADC Name Payload Target Linker Ref
Degly-mAb1-1-mc-vc-PAB-MMAE
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
[44]
ADC Info ADC Name Payload Target Linker Ref
177Lu-CHX-A"-DTPA-PODS-DVD
Lutetium-177
Undisclosed
PODS-CHX-A"-DTPA
[45]
Enfertuzumab
ADC Info ADC Name Payload Target Linker Ref
Enfertuzumab-compound 1100
Undisclosed
Undisclosed
Undisclosed
[46]
Enfertuzumab-compound 1101
Undisclosed
Undisclosed
Undisclosed
[46]
Enfertuzumab-compound 1102
Undisclosed
Undisclosed
Undisclosed
[46]
Enfertuzumab-compound 1103
Undisclosed
Undisclosed
Undisclosed
[46]
Enfertuzumab-compound 1574
Undisclosed
Undisclosed
Undisclosed
[46]
Enfertuzumab-compound 1105
Undisclosed
Undisclosed
Undisclosed
[46]
Enfertuzumab-compound 1106
Undisclosed
Undisclosed
Undisclosed
[46]
Enfertuzumab-compound 1199
Undisclosed
Undisclosed
Undisclosed
[46]
Engineered trastuzumab
ADC Info ADC Name Payload Target Linker Ref
Trastuzumab-C239I-SG3600
N10-beta-glucuronide SG3200
Human Deoxyribonucleic acid (hDNA)
Mal-PEG8-Val-Ala-PABC
[47]
Trastuzumab-C239I-SG3400
SG3200
Human Deoxyribonucleic acid (hDNA)
Mal-PEG8-Val-Ala-PABC
[47]
Engineered HER-SG3227
SG2219
Human Deoxyribonucleic acid (hDNA)
Acetamide-PEG4-Val-Ala-PABA
[48]
ADC Info ADC Name Payload Target Linker Ref
FM2b-F-D2
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
[49]
ADC Info ADC Name Payload Target Linker Ref
FM2b-K-D2
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
[49]
ADC Info ADC Name Payload Target Linker Ref
FM2b-S-D2
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
[49]
ADC Info ADC Name Payload Target Linker Ref
FM2b-Y-D2
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
[49]
Gancotamab
ADC Info ADC Name Payload Target Linker Ref
Gancotamab-ADC-Tb3-1
Gancotamab-ADC-Tb3-1 payload
Undisclosed
Gancotamab-ADC-Tb3-1 linker
[7]
Gancotamab-ADC-Tb3-2
Gancotamab-ADC-Tb3-2 payload
Undisclosed
Gancotamab-ADC-Tb3-2 linker
[7]
Gancotamab-ADC-Tb3-3
Gancotamab-ADC-Tb3-3 payload
Undisclosed
Gancotamab-ADC-Tb3-3 linker
[7]
Gancotamab-ADC-Tb3-4
Gancotamab-ADC-Tb3-4 payload
Undisclosed
Gancotamab-ADC-Tb3-4 linker
[7]
Gancotamab-ADC-Tb3-5
Gancotamab-ADC-Tb3-5 payload
Undisclosed
Gancotamab-ADC-Tb3-5 linker
[7]
Gancotamab-ADC-Tb3-6
Gancotamab-ADC-Tb3-6 payload
Undisclosed
Gancotamab-ADC-Tb3-6 linker
[7]
Gancotamab-ADC-Tb3-7
Gancotamab-ADC-Tb3-7 payload
Undisclosed
Gancotamab-ADC-Tb3-7 linker
[7]
Gancotamab-ADC-Tb3-8
Gancotamab-ADC-Tb3-8 payload
Undisclosed
Gancotamab-ADC-Tb3-8 linker
[7]
Gancotamab-ADC-Tb3-9
Gancotamab-ADC-Tb3-9 payload
Undisclosed
Gancotamab-ADC-Tb3-9 linker
[7]
Gancotamab-ADC-Tb3-10
Gancotamab-ADC-Tb3-10 payload
Undisclosed
Gancotamab-ADC-Tb3-10 linker
[7]
GGG-IL15Ralpha-IL15 208
ADC Info ADC Name Payload Target Linker Ref
BCN-PEG12-IL15Ralpha-IL15
Undisclosed
Undisclosed
Undisclosed
[41]
ADC Info ADC Name Payload Target Linker Ref
WO2022228495A1 ADC-73
WO2022228495A1 ADC-73 payload
Undisclosed
WO2022228495A1 ADC-73 linker
[50]
H01L02-Dxd
DX-8951 derivative (DXd)
DNA topoisomerase 1 (TOP1)
Mc-Gly-Gly-Phe-Gly
[51]
ADC Info ADC Name Payload Target Linker Ref
H02L02-Dxd
DX-8951 derivative (DXd)
DNA topoisomerase 1 (TOP1)
Mc-Gly-Gly-Phe-Gly
[51]
ADC Info ADC Name Payload Target Linker Ref
H02L03-Dxd
DX-8951 derivative (DXd)
DNA topoisomerase 1 (TOP1)
Mc-Gly-Gly-Phe-Gly
[51]
ADC Info ADC Name Payload Target Linker Ref
H04L02-Dxd
DX-8951 derivative (DXd)
DNA topoisomerase 1 (TOP1)
Mc-Gly-Gly-Phe-Gly
[51]
HER2 (L328C)
ADC Info ADC Name Payload Target Linker Ref
anti-HER2 Ab (L328C)-vcMMAE
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
[52]
HER2-C Anti-ody
ADC Info ADC Name Payload Target Linker Ref
HER2-C Antibody-Compound (X)
HER2-C Antibody-Compound (X) payload
Undisclosed
HER2-C Antibody-Compound (X) linker
[53]
HER2-C Antibody-Compound (XI)
HER2-C Antibody-Compound (XI) payload
Undisclosed
HER2-C Antibody-Compound (XI) linker
[53]
HER2-C Antibody-Compound (XIV)
HER2-C Antibody-Compound (XIV) payload
Undisclosed
HER2-C Antibody-Compound (XIV) linker
[53]
HER2-C Antibody-Compound (XVIII)
HER2-C Antibody-Compound (XVIII) payload
Undisclosed
HER2-C Antibody-Compound (XVIII) linker
[53]
HER2-C Antibody-Compound (Ie)
HER2-C Antibody-Compound (Ie) payload
Undisclosed
HER2-C Antibody-Compound (Ie) linker
[53]
HER2-C Antibody-Compound (XIX)
HER2-C Antibody-Compound (XIX) payload
Undisclosed
HER2-C Antibody-Compound (XIX) linker
[53]
HER2-C Antibody-Compound (Ii)
HER2-C Antibody-Compound (Ii) payload
Undisclosed
HER2-C Antibody-Compound (Ii) linker
[53]
HER2-C Antibody-Compound (XLI)
HER2-C Antibody-Compound (XLI) payload
Undisclosed
HER2-C Antibody-Compound (XLI) linker
[53]
HER2-C Antibody-Compound (XVI)
HER2-C Antibody-Compound (XIX) payload
Undisclosed
HER2-C Antibody-Compound (XIX) linker
[53]
HER2-C Antibody-Compound (XL)
HER2-C Antibody-Compound (XL) payload
Undisclosed
HER2-C Antibody-Compound (XL) linker
[53]
HER2-C Antibody-Compound (XLIII)
HER2-C Antibody-Compound (XLIII) payload
Undisclosed
HER2-C Antibody-Compound (XLIII) linker
[53]
HER2-C Antibody-Compound (XLII)
HER2-C Antibody-Compound (XLII) payload
Undisclosed
HER2-C Antibody-Compound (XLII) linker
[53]
HER2-C Antibody-Compound (XV)
HER2-C Antibody-Compound (XV) payload
Undisclosed
HER2-C Antibody-Compound (XV) linker
[53]
Her2-PT-A114C-hGl
ADC Info ADC Name Payload Target Linker Ref
Her2-PT-A114C-hGl- LP2
Undisclosed
Undisclosed
Undisclosed
[54]
Her2-PT-A114C-hGl-LP48
Undisclosed
Undisclosed
Undisclosed
[54]
Her2-PT-H16-K222R-hG1
ADC Info ADC Name Payload Target Linker Ref
Her2-PT-H16-K222R- hG1-LP1
Undisclosed
Undisclosed
Undisclosed
[54]
Her2-PT-H16-K222R- hGl-LP13
Undisclosed
Undisclosed
Undisclosed
[54]
Her2-PT-H16-K222R- hGl-LP49
Undisclosed
Undisclosed
Undisclosed
[54]
Her2-PT-H16-K222R- hGl-LP19
Undisclosed
Undisclosed
Undisclosed
[54]
Her2-PT-H16-K222R-Hg1
ADC Info ADC Name Payload Target Linker Ref
Her2-PT-H16-K222R- hG1-LP6
Undisclosed
Undisclosed
Undisclosed
[54]
Her2-PT-H7C-K222R-hGl
ADC Info ADC Name Payload Target Linker Ref
Her2-PT-H7C-K222R- hGl-LP19
Undisclosed
Undisclosed
Undisclosed
[54]
Her2-PT-LCQ05- K222R-hGl
ADC Info ADC Name Payload Target Linker Ref
Her2-PT-LCQ05- K222R-hGl-LP19
Undisclosed
Undisclosed
Undisclosed
[54]
Hertuzumab
ADC Info ADC Name Payload Target Linker Ref
Hertuzumab vedotin
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
[55]
Disitamab-ADC-Tb3-1
Disitamab-ADC-Tb3-1 payload
Undisclosed
Disitamab-ADC-Tb3-1 linker
[7]
Disitamab-ADC-Tb3-2
Disitamab-ADC-Tb3-2 payload
Undisclosed
Disitamab-ADC-Tb3-2 linker
[7]
Disitamab-ADC-Tb3-3
Disitamab-ADC-Tb3-3 payload
Undisclosed
Disitamab-ADC-Tb3-3 linker
[7]
Disitamab-ADC-Tb3-4
Disitamab-ADC-Tb3-4 payload
Undisclosed
Disitamab-ADC-Tb3-4 linker
[7]
Disitamab-ADC-Tb3-5
Disitamab-ADC-Tb3-5 payload
Undisclosed
Disitamab-ADC-Tb3-5 linker
[7]
Disitamab-ADC-Tb3-6
Disitamab-ADC-Tb3-6 payload
Undisclosed
Disitamab-ADC-Tb3-6 linker
[7]
Disitamab-ADC-Tb3-7
Disitamab-ADC-Tb3-7 payload
Undisclosed
Disitamab-ADC-Tb3-7 linker
[7]
Disitamab-ADC-Tb3-8
Disitamab-ADC-Tb3-8 payload
Undisclosed
Disitamab-ADC-Tb3-8 linker
[7]
Disitamab-ADC-Tb3-9
Disitamab-ADC-Tb3-9 payload
Undisclosed
Disitamab-ADC-Tb3-9 linker
[7]
Disitamab-ADC-Tb3-10
Disitamab-ADC-Tb3-10 payload
Undisclosed
Disitamab-ADC-Tb3-10 linker
[7]
ADC Info ADC Name Payload Target Linker Ref
WO2024140447A1 ADC 1
WO2024140447A1 ADC 1 Payload
Undisclosed
WO2024140447A1 ADC 1 Linker
[56]
WO2024140447A1 ADC 3
WO2024140447A1 ADC 1 Payload
Undisclosed
WO2024140447A1 ADC 3 Linker
WO2024140447A1 ADC 5
WO2024140447A1 ADC 1 Payload
Undisclosed
WO2024140447A1 ADC 4 Linker
WO2024140447A1 ADC 7
WO2024140447A1 ADC 1 Payload
Undisclosed
WO2024140447A1 ADC 7 Linker
WO2024140447A1 ADC 9
WO2024140447A1 ADC 1 Payload
Undisclosed
WO2024140447A1 ADC 9 Linker
WO2024140447A1 ADC 11
WO2024140447A1 ADC 1 Payload
Undisclosed
WO2024140447A1 ADC 11 Linker
WO2024140447A1 ADC 13
WO2024140447A1 ADC 13 Payload
Undisclosed
WO2024140447A1 ADC 13 Linker
WO2024140447A1 ADC 15
WO2024140447A1 ADC 13 Payload
Undisclosed
WO2024140447A1 ADC 15 Linker
WO2024140447A1 ADC 17
WO2024140447A1 ADC 13 Payload
Undisclosed
WO2024140447A1 ADC 17 Linker
WO2024140447A1 ADC 19
WO2024140447A1 ADC 13 Payload
Undisclosed
WO2024140447A1 ADC 3 Linker
WO2024140447A1 ADC 21
WO2024140447A1 ADC 13 Payload
Undisclosed
WO2024140447A1 ADC 21 Linker
WO2024140447A1 ADC 23
WO2024140447A1 ADC 13 Payload
Undisclosed
WO2024140447A1 ADC 23 Linker
WO2024140447A1 ADC 25
WO2024140447A1 ADC 1 Payload
Undisclosed
WO2024140447A1 ADC 25 Linker
WO2024140450A1 7-[N- (HS627-mc-Gly-Gly-Phe-Gly-ha-Ac), N- (S)-methoxyisopropyl]aminomethyl-10,11-methylenedioxycamptothecin
Undisclosed
Undisclosed
Undisclosed
[57]
WO2024140450A1 7-[N- (HS627-Ac-PEG2-Val-Ala-PABC), N- (S)-methoxyisopropyl]aminomethyl-10,11-methylenedioxycamptothecin
Undisclosed
Undisclosed
Undisclosed
[57]
WO2024140450A1 7-[N- (HS627-Ac-PEG2-Gly-Gly-Leu-Gly-ha-Ac), N- (S)-methyl-2-oxoethyl]-10,11-methylenedi-10,11-dihydroxycamptothecin
Undisclosed
Undisclosed
Undisclosed
[57]
WO2024140450A1 7-[N- (HS627-Ac-PEG2-Val-Ala-PABC), N-methoxyethyl]aminoethyl-10,11-methylenedioxycamptothecin
Undisclosed
Undisclosed
Undisclosed
[57]
WO2024140450A1 7-[N- (HS627-Ac-PEG2-Gly-Gly-Leu-Gly-ha-Ac), N-methoxyethyl]aminoethyl-10,11-methylenedi-6-mercaptopurine
Undisclosed
Undisclosed
Undisclosed
[57]
WO2024140450A1 7-[N- (HS627-Ac-PEG2-Gly-Gly-Lys-Gly-ha-Ac), N- (S)-methylisopropyl]aminoethyl-10,11-methylenedi-10,11-ethenylhyerocytosine
Undisclosed
Undisclosed
Undisclosed
[57]
WO2024140450A1 7-[N- (HS627-Ac-PEG2-Gly-Lys-PABC), N- (S)-methylisopropyl]aminoethyl-10,11-methylenedi-10,11-ethenylhydragranin 4.3
Undisclosed
Undisclosed
Undisclosed
[57]
HS627 ADC1
Undisclosed
Undisclosed
Undisclosed
[58]
HS627 ADC2
Undisclosed
Undisclosed
Undisclosed
[58]
HS627 ADC3
Undisclosed
Undisclosed
Undisclosed
[58]
CN116785448A ADC1
CN116785448A ADC1 payload
Undisclosed
CN116785448A ADC8 linker
[59]
CN116785448A ADC2
CN116785448A ADC2 payload
Undisclosed
CN116785448A ADC2 linker
[59]
CN116785448A ADC3
CN116785448A ADC5 payload
Undisclosed
CN116785448A ADC8 linker
[59]
CN116785448A ADC4
CN116785448A ADC4 payload
Undisclosed
CN116785448A ADC4 linker
[59]
CN116785448A ADC5
CN116785448A ADC5 payload
Undisclosed
CN116785448A ADC5 linker
[59]
CN116785448A ADC6
CN116785448A ADC6 payload
Undisclosed
CN116785448A ADC6 linker
[59]
CN116785448A ADC7
CN116785448A ADC7 payload
Undisclosed
CN116785448A ADC7 linker
[59]
CN116785448A ADC8
CN116785448A ADC8 payload
Undisclosed
CN116785448A ADC8 linker
[59]
HS627- (C1)2
undisclosed
Undisclosed
Undisclosed
[60]
HS627- (C1)4
undisclosed
Undisclosed
Undisclosed
[60]
(C6)4-HS627- (C1)2
undisclosed
Undisclosed
Undisclosed
[60]
HS627- (C2)2
undisclosed
Undisclosed
Undisclosed
[60]
HS627- (C4)4 3.8
undisclosed
Undisclosed
Undisclosed
[60]
(C0)4-HS627- (C2)2
undisclosed
Undisclosed
Undisclosed
[60]
HS627- (C3)2
undisclosed
Undisclosed
Undisclosed
[60]
HS627- (C3)4
undisclosed
Undisclosed
Undisclosed
[60]
(C0)4-HS627- (C3)2
undisclosed
Undisclosed
Undisclosed
[60]
HS627- (C4)2
undisclosed
Undisclosed
Undisclosed
[60]
HS627- (C4)4 3.7
undisclosed
Undisclosed
Undisclosed
[60]
(C6)4-HS627- (C4)2
undisclosed
Undisclosed
Undisclosed
[60]
HS627- (C5)2
undisclosed
Undisclosed
Undisclosed
[60]
HS627- (C5)4
undisclosed
Undisclosed
Undisclosed
[60]
(C0)4-HS627- (C5)2
undisclosed
Undisclosed
Undisclosed
[60]
HS627- (C6)2
undisclosed
Undisclosed
Undisclosed
[60]
HS627- (C6)4
undisclosed
Undisclosed
Undisclosed
[60]
(C0)4-HS627- (C6)2
undisclosed
Undisclosed
Undisclosed
[60]
HS627- (C7)2
undisclosed
Undisclosed
Undisclosed
[60]
HS627- (C7)4
undisclosed
Undisclosed
Undisclosed
[60]
(C6)4-HS627- (C7)2
undisclosed
Undisclosed
Undisclosed
[60]
HS627- (C8)2
undisclosed
Undisclosed
Undisclosed
[60]
HS627- (C8)4
undisclosed
Undisclosed
Undisclosed
[60]
(C0)4-HS627- (C8)2
undisclosed
Undisclosed
Undisclosed
[60]
ADC Info ADC Name Payload Target Linker Ref
hSD5-vedotin
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
[61]
hu4DFabv7
ADC Info ADC Name Payload Target Linker Ref
hu4DFabv7-BMPEO-DM1
Maytansinoid DM1
Microtubule (MT)
hu4DFabv7-BMPEO-DM1 linker
[14]
hu4DFabv8 (A121C)
ADC Info ADC Name Payload Target Linker Ref
hu4DFabv8 (A121C)-BMPEO-DM1
Maytansinoid DM1
Microtubule (MT)
hu4DFabv8 (A121C)-BMPEO-DM1 linker
[14]
hu4DFabv8 (H-A175C)
ADC Info ADC Name Payload Target Linker Ref
hu4DFabv8 (H-A175C)-BMPEO-DM1
Maytansinoid DM1
Microtubule (MT)
hu4DFabv8 (H-A175C)-BMPEO-DM1 linker
[14]
hu4DFabv8 (H-A40C)
ADC Info ADC Name Payload Target Linker Ref
hu4DFabv8 (H-A40C)-BMPEO-DM1
Maytansinoid DM1
Microtubule (MT)
hu4DFabv8 (H-A40C)-BMPEO-DM1 linker
[14]
hu4DFabv8 (H-A88C)
ADC Info ADC Name Payload Target Linker Ref
hu4DFabv8 (H-A88C)-BMPEO-DM1
Maytansinoid DM1
Microtubule (MT)
hu4DFabv8 (H-A88C)-BMPEO-DM1 linker
[14]
hu4DFabv8 (H-S119C)
ADC Info ADC Name Payload Target Linker Ref
hu4DFabv8 (H-S119C)-BMPEO-DM1
Maytansinoid DM1
Microtubule (MT)
hu4DFabv8 (H-S119C)-BMPEO-DM1 linker
[14]
hu4DFabv8 (H-S122C)
ADC Info ADC Name Payload Target Linker Ref
hu4DFabv8 (H-S122C)-BMPEO-DM1
Maytansinoid DM1
Microtubule (MT)
hu4DFabv8 (H-S122C)-BMPEO-DM1 linker
[14]
hu4DFabv8 (H-S179C)
ADC Info ADC Name Payload Target Linker Ref
hu4DFabv8 (H-S179C)-BMPEO-DM1
Maytansinoid DM1
Microtubule (MT)
hu4DFabv8 (H-S179C)-BMPEO-DM1 linker
[14]
hu4DFabv8 (L-A144C)
ADC Info ADC Name Payload Target Linker Ref
hu4DFabv8 (L-A144C)-BMPEO-DM1
Maytansinoid DM1
Microtubule (MT)
hu4DFabv8 (L-A144C)-BMPEO-DM1 linker
[14]
hu4DFabv8 (L-A43C)
ADC Info ADC Name Payload Target Linker Ref
hu4DFabv8 (L-A43C)-BMPEO-DM1
Maytansinoid DM1
Microtubule (MT)
hu4DFabv8 (L-A43C)-BMPEO-DM1 linker
[14]
hu4DFabv8 (L-S168C)
ADC Info ADC Name Payload Target Linker Ref
hu4DFabv8 (L-S168C)-BMPEO-DM1
Maytansinoid DM1
Microtubule (MT)
hu4DFabv8 (L-S168C)-BMPEO-DM1 linker
[14]
hu4DFabv8 (L-V15C)
ADC Info ADC Name Payload Target Linker Ref
hu4DFabv8 (L-V15C)-BMPEO-DM1
Maytansinoid DM1
Microtubule (MT)
hu4DFabv8 (L-V15C)-BMPEO-DM1 linker
[14]
hu4DFabv8 (V110C)
ADC Info ADC Name Payload Target Linker Ref
hu4DFabv8 (V110C)-BMPEO-DM1
Maytansinoid DM1
Microtubule (MT)
hu4DFabv8 (V110C)-BMPEO-DM1 linker
[14]
hu4DFabv8 (V110C)-MC-MMAF
Monomethyl auristatin F
Microtubule (MT)
Maleimido-caproyl
[14]
hu4DFabv8 (V110C)-MC-MMAE
Monomethyl auristatin E
Microtubule (MT)
Maleimido-caproyl
[14]
hu4DFabv8 (V110C)-MC-Val-Cit-PAB-MMAF
Monomethyl auristatin F
Microtubule (MT)
Mc-Val-Cit-PABC
[14]
hu4DFabv8 (V110C)-MC-Val-Cit-PAB-MMAE
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
[14]
ADC Info ADC Name Payload Target Linker Ref
WO2024140447A1 ADC 2
WO2024140447A1 ADC 1 Payload
Undisclosed
WO2024140447A1 ADC 1 Linker
WO2024140447A1 ADC 4
WO2024140447A1 ADC 1 Payload
Undisclosed
Undisclosed
WO2024140447A1 ADC 6
WO2024140447A1 ADC 1 Payload
Undisclosed
WO2024140447A1 ADC 4 Linker
WO2024140447A1 ADC 8
WO2024140447A1 ADC 1 Payload
Undisclosed
WO2024140447A1 ADC 7 Linker
WO2024140447A1 ADC 10
WO2024140447A1 ADC 1 Payload
Undisclosed
WO2024140447A1 ADC 9 Linker
WO2024140447A1 ADC 12
WO2024140447A1 ADC 1 Payload
Undisclosed
WO2024140447A1 ADC 11 Linker
WO2024140447A1 ADC 14
WO2024140447A1 ADC 13 Payload
Undisclosed
WO2024140447A1 ADC 13 Linker
WO2024140447A1 ADC 16
WO2024140447A1 ADC 13 Payload
Undisclosed
WO2024140447A1 ADC 15 Linker
WO2024140447A1 ADC 18
WO2024140447A1 ADC 13 Payload
Undisclosed
WO2024140447A1 ADC 17 Linker
WO2024140447A1 ADC 20
WO2024140447A1 ADC 13 Payload
Undisclosed
WO2024140447A1 ADC 3 Linker
WO2024140447A1 ADC 22
WO2024140447A1 ADC 13 Payload
Undisclosed
WO2024140447A1 ADC 21 Linker
WO2024140447A1 ADC 24
WO2024140447A1 ADC 13 Payload
Undisclosed
WO2024140447A1 ADC 23 Linker
WO2024140447A1 ADC 26
WO2024140447A1 ADC 1 Payload
Undisclosed
WO2024140447A1 ADC 25 Linker
WO2024140449A1 ADC2
WO2024140449A1+ADC1+payload
Undisclosed
Mc-Val-Cit
[62]
WO2024140449A1 ADC4
WO2024140449A1+ADC1+payload
Undisclosed
WO2024140449A1+ADC3+Linker
[62]
WO2024140449A1 ADC6
WO2024140449A1+ADC5+payload
DNA topoisomerase I (TOP1)
WO2024140449A1+ADC5+Linker
[62]
WO2024140449A1 ADC8
WO2024140449A1+ADC5+payload
DNA topoisomerase I (TOP1)
WO2024140449A1+ADC7+Linker
[62]
WO2024140449A1 ADC10
WO2024140449A1+ADC5+payload
DNA topoisomerase I (TOP1)
WO2024140449A1+ADC9+Linker
[62]
WO2024140449A1 ADC12
WO2024140449A1+ADC5+payload
DNA topoisomerase I (TOP1)
WO2024140449A1+ADC9+Linker
[62]
WO2024140449A1 ADC14
WO2024140449A1+ADC13+payload
Undisclosed
WO2024140449A1+ADC13+Linker
[62]
WO2024140449A1 ADC16
WO2024140449A1+ADC13+payload
Undisclosed
WO2024140449A1+ADC13+Linker
[62]
WO2024140449A1 ADC18
WO2024140449A1+ADC17+payload
Undisclosed
WO2024140449A1+ADC17+Linker
[62]
WO2024140449A1 ADC20
WO2024140449A1+ADC19+payload
Undisclosed
WO2024140449A1+ADC19+Linker
[62]
WO2024140449A1 ADC22
WO2024140449A1+ADC5+payload
DNA topoisomerase I (TOP1)
WO2024140449A1+ADC5+Linker
[62]
WO2024140450A1 7-[N- (IP140B-mc-Gly-Gly-Phe-Gly-ha-Ac), N- (S)-methoxyisopropyl]aminomethyl-10,11-methylenedioxycamptothecin
Undisclosed
Undisclosed
Undisclosed
[57]
WO2024140450A1 7-[N- (1P140B-Ac-PEG2-Val-Ala-PABC), N- (S)-methylisopropyl]aminoethyl-10,11-methylenedioxycamptothecin
Undisclosed
Undisclosed
Undisclosed
[57]
WO2024140450A1 7-[N- (IP140B-Ac-PEG2-Gly-Gly-Leu-Gly-ha-Ac), N- (S)-methylisopropyl]aminoethyl-10,11-methylenedi-10,11-ethenyl-10,11-dihydroxycamptothecin
Undisclosed
Undisclosed
Undisclosed
[57]
WO2024140450A1 7-[N- (IP140B-Ac-PEG2-Val-Ala-PABC), N-methoxyethyl]aminoethyl-10,11-methylenedi-6,7-dihydroxystilbene
Undisclosed
Undisclosed
Undisclosed
[57]
WO2024140450A1 7-[N- (IP140B-Ac-PEG2-Gly-Gly-Leu-Gly-ha-Ac), N-methoxyethyl]aminoethyl-10,11-methylenedi-6,7-ethenidinocamptothecin
Undisclosed
Undisclosed
Undisclosed
[57]
WO2024140450A1 7-[N- (IP140B-Ac-PEGz-Gly-Gly-Lys-Gly-ha-Ac), N- (S)-methylisopropyl]aminoethyl-10,11-methylenedi-10,11-ethenylhyerocytosine
Undisclosed
Undisclosed
Undisclosed
[57]
WO2024140450A1 7-[N- (HS627-Ac-PEG2-Gly-Lys-PABC), N- (S)-methylisopropyl]aminoethyl-10,11-methylenedi-10,11-ethenylhydragranin 4.6
Undisclosed
Undisclosed
Undisclosed
[57]
IP140B ADC1
Undisclosed
Undisclosed
Undisclosed
[58]
IP140B ADC2
Undisclosed
Undisclosed
Undisclosed
[58]
IP140B ADC3
Undisclosed
Undisclosed
Undisclosed
[58]
CN117159739A ADC1
undisclosed
Undisclosed
Undisclosed
[63]
CN117159739A ADC2
undisclosed
Undisclosed
Undisclosed
[63]
CN117159739A ADC5
undisclosed
Undisclosed
Undisclosed
[63]
Isoprenylated trastuzumab
ADC Info ADC Name Payload Target Linker Ref
LCB-ADC3
Monomethyl auristatin F
Microtubule (MT)
Bridged PEG4-valine-alanine
[64]
LCB-ADC2
Monomethyl auristatin F
Microtubule (MT)
Isoprene-PEG3,3,3-beta-Glu-PABC
[64]
LCB-ADC1
Monomethyl auristatin F
Microtubule (MT)
Isoprene-PEG3-beta-Glu-PABC
[64]
LOL1-HER2 (L234A, L235A, L328C)
ADC Info ADC Name Payload Target Linker Ref
LOL1-anti-HER2 Ab (L234A, L235A, L328C)
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
[52]
M30-H1-L4P
ADC Info ADC Name Payload Target Linker Ref
WO2022099762A1 ADCa
Camptothecin
DNA topoisomerase 1 (TOP1)
WO2022099762A1 10
[65]
WO2022099762A1 ADCb
Camptothecin
DNA topoisomerase 1 (TOP1)
Mc-Gly-Gly-Phe-Gly
[65]
ADC Info ADC Name Payload Target Linker Ref
IN202417103839A ADC-1
Undisclosed
Undisclosed
Undisclosed
[66]
ADC Info ADC Name Payload Target Linker Ref
IN202417103839A ADC-2
Undisclosed
Undisclosed
Undisclosed
[66]
IN202417103839A ADC-3
Undisclosed
Undisclosed
Undisclosed
[66]
IN202417103839A ADC-4
Undisclosed
Undisclosed
Undisclosed
[66]
IN202417103839A ADC-5
Undisclosed
Undisclosed
Undisclosed
[66]
ADC Info ADC Name Payload Target Linker Ref
IN202417103839A ADC-6
Undisclosed
Undisclosed
Undisclosed
[66]
ADC Info ADC Name Payload Target Linker Ref
WO2024140927A1-ADC-A (DAR4)
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
[67]
WO2024140927A1-ADC-D (DAR6)
Active metabolite of irinotecan SN38
DNA topoisomerase 1 (TOP1)
CL2A
[67]
WO2024140927A1-ADC-D (DAR2)
Active metabolite of irinotecan SN38
DNA topoisomerase 1 (TOP1)
CL2A
[67]
WO2024140927A1-ADC-E (DAR6)
Doxorubicin
DNA topoisomerase 2-alpha (TOP2A)
Succinimidyl-4- (N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
[67]
WO2024140927A1-ADC-E (DAR2)
Doxorubicin
DNA topoisomerase 2-alpha (TOP2A)
Succinimidyl-4- (N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
[67]
WO2024140927A1-ADC-A (DAR6)
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
[67]
WO2024140927A1-ADC-A (DAR2)
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
[67]
ADC Info ADC Name Payload Target Linker Ref
mAb1-mc-vc-PAB-MMAE
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
[44]
mAb1-MMAE
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
[68]
mAb1-MMAF
Monomethyl auristatin F
Microtubule (MT)
Mc-Val-Cit-PABC
[68]
mAb1-DXd
DX-8951 derivative (DXd)
DNA topoisomerase 1 (TOP1)
Mc-Gly-Gly-Phe-Gly
[68]
mAb1-Extecan
Exatecan
DNA topoisomerase 1 (TOP1)
Mc-Gly-Gly-Phe-Gly
[68]
mAb1-DAR6-PB
Undisclosed
Undisclosed
Undisclosed
[68]
mAb1-DAR6-HEPES
Undisclosed
Undisclosed
Undisclosed
[68]
mAb1-DAR6-MES
Undisclosed
Undisclosed
Undisclosed
[68]
mAb1-DAR6-Tris
Undisclosed
Undisclosed
Undisclosed
[68]
mAb1-DAR6-MOPSO
Undisclosed
Undisclosed
Undisclosed
[68]
mAb17-DM21
Undisclosed
Undisclosed
Undisclosed
[68]
mAb1-MMAF+MMAE
Undisclosed
Undisclosed
Undisclosed
[68]
mAb1-MMAE+MMAF
Undisclosed
Undisclosed
Undisclosed
[68]
mAb1-MMAE+DXd
Undisclosed
Undisclosed
Undisclosed
[68]
mAb1-DXd+MMAE
Undisclosed
Undisclosed
Undisclosed
[68]
mAb1-DXd+MMAE+MMAF
Undisclosed
Undisclosed
Undisclosed
[68]
mAb1-MMAE+GGFG-DXd
Undisclosed
Undisclosed
Undisclosed
[68]
MAb1-DAR6-HEPES-20mM
Undisclosed
Undisclosed
Undisclosed
[68]
MAb1-DAR6-HEPES-40mM
Undisclosed
Undisclosed
Undisclosed
[68]
MAb1-DAR6-HEPES-60mM
Undisclosed
Undisclosed
Undisclosed
[68]
MAb1-DAR6-HEPES-80mM
Undisclosed
Undisclosed
Undisclosed
[68]
mAb1-DAR6-1mg·mL-1
Undisclosed
Undisclosed
Undisclosed
[68]
mAb1-DAR6-2.5mg·mL-1
Undisclosed
Undisclosed
Undisclosed
[68]
mAb1-DAR6-5mg·mL-1
Undisclosed
Undisclosed
Undisclosed
[68]
mAb1-DAR6-10mg·mI-1
Undisclosed
Undisclosed
Undisclosed
[68]
mAb1-DAR6-15mg·mL-1
Undisclosed
Undisclosed
Undisclosed
[68]
mAb1-DAR6-20mg·mL-1
Undisclosed
Undisclosed
Undisclosed
[68]
mAb1-DAR6-4°C/10.00 TCEP
Undisclosed
Undisclosed
Undisclosed
[68]
mAb1-DAR6-4°C/12.00 TCEP
Undisclosed
Undisclosed
Undisclosed
[68]
mAb1-DAR6-4°C/14.00 TCEP
Undisclosed
Undisclosed
Undisclosed
[68]
mAb1-DAR6-12°C/3.25 TCEP
Undisclosed
Undisclosed
Undisclosed
[68]
mAb1-DAR6-12°C/3.75 TCEP
Undisclosed
Undisclosed
Undisclosed
[68]
mAb1-DAR6-16°C/3.00 TCEP
Undisclosed
Undisclosed
Undisclosed
[68]
mAb1-DAR6-16°C/3.25 TCEP
Undisclosed
Undisclosed
Undisclosed
[68]
mAb1-DAR6-22°C/2.85 TCEP
Undisclosed
Undisclosed
Undisclosed
[68]
mAb1-DAR6-22°C/3.00 TCEP
Undisclosed
Undisclosed
Undisclosed
[68]
mAb1-DAR6-pH 6.8
Undisclosed
Undisclosed
Undisclosed
[68]
mAb1-DAR6-pH 7.0
Undisclosed
Undisclosed
Undisclosed
[68]
mAb1-DAR6-pH 7.4
Undisclosed
Undisclosed
Undisclosed
[68]
mAb1-DAR6-pH 8.0
Undisclosed
Undisclosed
Undisclosed
[68]
mAb1-Tween 20
Undisclosed
Undisclosed
Undisclosed
[68]
mAb1-Benzyl Alcohol
Undisclosed
Undisclosed
Undisclosed
[68]
mAb1-Trehalose
Undisclosed
Undisclosed
Undisclosed
[68]
mAb1-Extecan+MMAE
Undisclosed
Undisclosed
Undisclosed
[68]
mAb1-DBM-MMAF
Undisclosed
Undisclosed
Undisclosed
[68]
mAb1-STB-MMAE
Undisclosed
Undisclosed
Undisclosed
[68]
mAb1-Bimaleimide-MMAE
Undisclosed
Undisclosed
Undisclosed
[68]
WO2024118785A3 Lot2
Undisclosed
Undisclosed
Undisclosed
[69]
WO2024118785A3 Lot3
Undisclosed
Undisclosed
Undisclosed
[69]
WO2024118785A3 Lot5
Undisclosed
Undisclosed
Undisclosed
[69]
WO2024118785A3 Lot7
Undisclosed
Undisclosed
Undisclosed
[69]
WO2024118785A3 Lot10
Undisclosed
Undisclosed
Undisclosed
[69]
WO2024118785A3 Lot14
Undisclosed
Undisclosed
Undisclosed
[69]
WO2024118785A3 Lot18
Undisclosed
Undisclosed
Undisclosed
[69]
WO2024118785A3 Lot20
Undisclosed
Undisclosed
Undisclosed
[69]
WO2024118785A3 Lot21
Undisclosed
Undisclosed
Undisclosed
[69]
WO2024118785A3 Lot43
Undisclosed
Undisclosed
Undisclosed
[69]
WO2024118785A3 Lot48
Undisclosed
Undisclosed
Undisclosed
[69]
WO2024118785A3 Lot52
Undisclosed
Undisclosed
Undisclosed
[69]
Ab-AL-LP2
Pro-DHT
Undisclosed
DIBAC-PEG4-vcPAB
[70]
Ab-AL-LP3
Pro-DHT
Undisclosed
DIBAC-PEG4-EvcPAB linker
[70]
Ab-AL-LP7
Pro-DHT
Undisclosed
COT-PEG4-branch-PEG2-EvcPAB
[70]
Ab-AL-LP41
DHT
Undisclosed
COT-PEG4-VK-PABC
[70]
Ab-BL-LP7
Pro-DHT
Undisclosed
COT-PEG4-branch-PEG2-EvcPAB
[70]
Ab-LP3A
Pro-DHT
Undisclosed
NH2-PEG4-EvcPAB
[70]
Ab-LP5A
DHT
Undisclosed
NH2-PEG4-EvcPAB-NHCH2
[70]
Ab-LP44
DHT
Undisclosed
NH2-PEG4-vcPABC
[70]
Ab-LP33
Pro-DHT
Undisclosed
Mc-PEG4-EvcPAB
[70]
Margetuximab
ADC Info ADC Name Payload Target Linker Ref
Margetuximab-ADC-Tb3-1
Margetuximab-ADC-Tb3-1 payload
Undisclosed
Margetuximab-ADC-Tb3-1 linker
[7]
Margetuximab-ADC-Tb3-2
Margetuximab-ADC-Tb3-2 payload
Undisclosed
Margetuximab-ADC-Tb3-2 linker
[7]
Margetuximab-ADC-Tb3-3
Margetuximab-ADC-Tb3-3 payload
Undisclosed
Margetuximab-ADC-Tb3-3 linker
[7]
Margetuximab-ADC-Tb3-4
Margetuximab-ADC-Tb3-4 payload
Undisclosed
Margetuximab-ADC-Tb3-4 linker
[7]
Margetuximab-ADC-Tb3-5
Margetuximab-ADC-Tb3-5 payload
Undisclosed
Margetuximab-ADC-Tb3-5 linker
[7]
Margetuximab-ADC-Tb3-6
Margetuximab-ADC-Tb3-6 payload
Undisclosed
Margetuximab-ADC-Tb3-6 linker
[7]
Margetuximab-ADC-Tb3-7
Margetuximab-ADC-Tb3-7 payload
Undisclosed
Margetuximab-ADC-Tb3-7 linker
[7]
Margetuximab-ADC-Tb3-8
Margetuximab-ADC-Tb3-8 payload
Undisclosed
Margetuximab-ADC-Tb3-8 linker
[7]
Margetuximab-ADC-Tb3-9
Margetuximab-ADC-Tb3-9 payload
Undisclosed
Margetuximab-ADC-Tb3-9 linker
[7]
Margetuximab-ADC-Tb3-10
Margetuximab-ADC-Tb3-10 payload
Undisclosed
Margetuximab-ADC-Tb3-10 linker
[7]
EP4487874A1-1
EP4487874A1-1payload
Undisclosed
EP4487874A1-1linker
[71]
EP4487874A1-4
EP4487874A1-4payload
Undisclosed
EP4487874A1-3linker
[71]
ADC Info ADC Name Payload Target Linker Ref
CN114605367B A-II-11C
Undisclosed
Undisclosed
Undisclosed
[72]
CN114605367B A-II-12C
A-II-12C Payload
Undisclosed
6-Maleimidocaproic acid
[72]
CN114605367B A-II-13C
A-II-13C Payload
Undisclosed
6-Maleimidocaproic acid
[72]
CN114605367B A-II-14C
A-II-14C Payload
Undisclosed
6-Maleimidocaproic acid
[72]
CN114605367B A-II-21-C
Undisclosed
Undisclosed
Undisclosed
[72]
CN114605367B A-II-22-C
A-II-22-C Payload
Undisclosed
6-Maleimidocaproic acid
[72]
CN114605367B A-II-23-C
A-II-23-C Payload
Undisclosed
6-Maleimidocaproic acid
[72]
CN114605367B A-II-24-C
A-II-24-C Payload
Undisclosed
6-Maleimidocaproic acid
[72]
CN114605367B A-III-11
Undisclosed
Undisclosed
Undisclosed
[72]
CN114605367B A-III-12
A-III-12 Payload
Undisclosed
6-Maleimidocaproic acid
[72]
CN114605367B A-III-13
A-III-13 Payload
Undisclosed
6-Maleimidocaproic acid
[72]
CN114605367B A-III-14
A-III-14 Payload
Undisclosed
6-Maleimidocaproic acid
[72]
CN114605367B A-III-21
Undisclosed
Undisclosed
Undisclosed
[72]
CN114605367B A-III-22
A-III-22 Payload
Undisclosed
6-Maleimidocaproic acid
[72]
CN114605367B A-III-23
A-III-23 Payload
Undisclosed
6-Maleimidocaproic acid
[72]
CN114605367B A-III-24
A-III-24 Payload
Undisclosed
6-Maleimidocaproic acid
[72]
CN114605367B IV-21
Undisclosed
Undisclosed
Undisclosed
[72]
CN114605367B IV-22
A-III-22 Payload
Undisclosed
6-Maleimidocaproic acid
[72]
CN114605367B IV-23
A-III-23 Payload
Undisclosed
6-Maleimidocaproic acid
[72]
CN114605367B IV-24
A-III-24 Payload
Undisclosed
6-Maleimidocaproic acid
[72]
CN114605367B IV-11
Undisclosed
Undisclosed
Undisclosed
[72]
CN114605367B IV-12
A-III-12 Payload
Undisclosed
6-Maleimidocaproic acid
[72]
CN114605367B IV-13
A-III-13 Payload
Undisclosed
6-Maleimidocaproic acid
[72]
CN114605367B IV-14
A-III-14 Payload
Undisclosed
6-Maleimidocaproic acid
[72]
ADC Info ADC Name Payload Target Linker Ref
Mil40-12B
Monomethyl auristatin E
Microtubule (MT)
Maleamic methyl ester-based linker 12B
[73]
Mil40-12B
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
[73]
Mil40-5
Active metabolite of irinotecan SN38
DNA topoisomerase 1 (TOP1)
Mc-Val-Ala-PABC
[74]
Mil40-6
Active metabolite of irinotecan SN38
DNA topoisomerase 1 (TOP1)
Mal-PEG2-Val-Ala-PABC
[74]
Mil40-7
Active metabolite of irinotecan SN38
DNA topoisomerase 1 (TOP1)
Mal-PEG4-Val-Ala-PABC
[74]
Mil40-8
Active metabolite of irinotecan SN38
DNA topoisomerase 1 (TOP1)
Mal-PEG8-Val-Ala-PABC
[74]
Mil40-12A
Monomethyl auristatin E
Microtubule (MT)
Maleamic methyl ester-based linker 12A
[73]
Mil40-12C
Monomethyl auristatin E
Microtubule (MT)
Maleamic methyl ester-based linker 12C
[73]
Mil40-11 (DAR=7.1)
Active metabolite of irinotecan SN38
DNA topoisomerase 1 (TOP1)
Mc-PEG8-Val-Ala-PABC
[74]
Mil40-11 (DAR=3.8)
Active metabolite of irinotecan SN38
DNA topoisomerase 1 (TOP1)
Mc-PEG8-Val-Ala-PABC
[74]
Cys-linker-MMAE-based ADC 11
Monomethyl auristatin E
Microtubule (MT)
Cys-11 ADC linker
[75]
Cys-linker-MMAE-based ADC 12
Monomethyl auristatin E
Microtubule (MT)
Cys-12 ADC linker
[75]
Cys-linker-MMAE-based ADC 13
Monomethyl auristatin E
Microtubule (MT)
Cys-13 ADC linker
[75]
Cys-linker-MMAE-based ADC 14
Monomethyl auristatin E
Microtubule (MT)
Cys-14 ADC linker
[75]
Cys-linker-MMAE-based ADC 15
Monomethyl auristatin E
Microtubule (MT)
Mc-PABC
[75]
Cys-linker-MMAE-based ADC 16
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
[75]
ADC Mil40-6
Monomethyl auristatin E
Microtubule (MT)
Silyl ether-based linker
[76]
Mil40-15
Monomethyl auristatin E
Microtubule (MT)
Mc-PABC
[75]
Trastuzumab biosimilar mil40 12a
Monomethyl auristatin E
Microtubule (MT)
Maleamic methyl ester-based Val-Ala-PABC linker 12a
[77]
Trastuzumab biosimilar mil40 12b
Monomethyl auristatin E
Microtubule (MT)
Maleamic methyl ester-based Val-Ala-PABC linker 12b
[77]
Trastuzumab biosimilar mil40 12c
Monomethyl auristatin E
Microtubule (MT)
Maleamic methyl ester-based Val-Cit-PABC linker 12c
[77]
ADC Info ADC Name Payload Target Linker Ref
EP3838893B1-ADC-I
Monomethyl auristatin E
Microtubule (MT)
Mm-C3-Val-Ala-PAB
[78]
EP3838893B1-ADC-II
Monomethyl auristatin E
Microtubule (MT)
Mm-C6-Val-Ala-PAB
[78]
EP3838893B1-ADC-III
Monomethyl auristatin E
Microtubule (MT)
Mm-C6-Val-Cit-PAB
[78]
EP3838893B1-ADC-IV
Undisclosed
Undisclosed
Mm-C6-Val-Cit-PAB
[78]
EP3838893B1-ADC-A
Monomethyl auristatin E
Microtubule (MT)
Mm-C6-PEG4-Val-Ala-PAB
[78]
EP3838893B1-ADC-B
Monomethyl auristatin E
Microtubule (MT)
Mm-C6-PEG8-Val-Ala-PAB
[78]
EP3838893B1-ADC-C
Monomethyl auristatin E
Microtubule (MT)
Mm-C6-PEG8'-Val-Ala-PAB
[78]
Su-C6-Val-Cit-PAB
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
[78]
Mm-C6-PEG4-Val-Ala-PAB-MMAE
Monomethyl auristatin E
Microtubule (MT)
Mm-C6-PEG4-Val-Ala-PAB
[78]
Mm-C6-PEG8-Val-Ala-PAB-MMAE
Monomethyl auristatin E
Microtubule (MT)
Mm-C6-PEG8-Val-Ala-PAB
[78]
Mm-C6-PEG8'-Val-Ala-PAB-MMAE
Monomethyl auristatin E
Microtubule (MT)
Mm-C6-PEG8'-Val-Ala-PAB
[78]
Su-C3-VA
Monomethyl auristatin E
Microtubule (MT)
PEG2-Val-Cit-PABC
[78]
Su-C6-VC
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
[78]
Su-C6-VA
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Ala-PABC
[78]
Minibody (4 cys)
ADC Info ADC Name Payload Target Linker Ref
Mb (4)-m- (b-PEG12)-VC-MMAE
Monomethyl auristatin E
Microtubule (MT)
IgG (8)-m- (b-PEG12)-VC-MMAE
[79]
Modified ZHER2:2891 protein (ZHER2)
ADC Info ADC Name Payload Target Linker Ref
Pyro-Linker-ZHER2
Pyropheophorbide-a
Undisclosed
Pyro-Linker based linker
[80]
mouse anti-human HER2 Ab
ADC Info ADC Name Payload Target Linker Ref
WO2023232144A1ADC34
WO2025015586A1, ADC34, Payload
Toll-like receptor 7 (TLR7); Toll-like receptor 8 (TLR8)
Mc-Val-Cit-PABC
[81]
WO2023232144A1ADC35
WO2025015586A1, ADC35, Payload
Toll-like receptor 7 (TLR7); Toll-like receptor 8 (TLR8)
Mc-Val-Cit-PABC
[81]
WO2023232144A1ADC36
WO2025015586A1, ADC34, Payload
Toll-like receptor 7 (TLR7); Toll-like receptor 8 (TLR8)
SMCC
[81]
WO2023232144A1ADC37
WO2025015586A1, ADC35, Payload
Toll-like receptor 7 (TLR7); Toll-like receptor 8 (TLR8)
SMCC
[81]
ADC Info ADC Name Payload Target Linker Ref
NOV0712-Dxd
DX-8951 derivative (DXd)
DNA topoisomerase 1 (TOP1)
Mc-Gly-Gly-Phe-Gly
[51]
Palivizumab_msIgG2a
ADC Info ADC Name Payload Target Linker Ref
Palivizumab_msIgG2a Conjugate 3
Undisclosed
Undisclosed
Undisclosed
[4]
Patritumab
ADC Info ADC Name Payload Target Linker Ref
WO2022228495A1 ADC-72
WO2022228495A1 ADC-72 payload
Undisclosed
WO2022228495A1 ADC-72 linker
[50]
Pertuzumab
ADC Info ADC Name Payload Target Linker Ref
WO2020063676A1 ADC-7
WO2020063676A1_ADC-7 payload
Undisclosed
WO2020063676A1_ADC-7 linker
[82]
WO2020063676A1 ADC-8
WO2020063676A1_ADC-8 payload
Undisclosed
WO2020063676A1_ADC-8 linker
[82]
WO2020063676A1 ADC-9
WO2020063676A1_ADC-9 payload
Undisclosed
WO2020063676A1_ADC-9 linker
[82]
Pertuzumab-ADC-Tb3-1
Pertuzumab-ADC-Tb3-1 payload
Undisclosed
Pertuzumab-ADC-Tb3-1 linker
[7]
Pertuzumab-ADC-Tb3-2
Pertuzumab-ADC-Tb3-2 payload
Undisclosed
Pertuzumab-ADC-Tb3-2 linker
[7]
Pertuzumab-ADC-Tb3-3
Pertuzumab-ADC-Tb3-3 payload
Undisclosed
Pertuzumab-ADC-Tb3-3 linker
[7]
Pertuzumab-ADC-Tb3-4
Pertuzumab-ADC-Tb3-4 payload
Undisclosed
Pertuzumab-ADC-Tb3-4 linker
[7]
Pertuzumab-ADC-Tb3-5
Pertuzumab-ADC-Tb3-5 payload
Undisclosed
Pertuzumab-ADC-Tb3-5 linker
[7]
Pertuzumab-ADC-Tb3-6
Pertuzumab-ADC-Tb3-6 payload
Undisclosed
Pertuzumab-ADC-Tb3-6 linker
[7]
Pertuzumab-ADC-Tb3-7
Pertuzumab-ADC-Tb3-7 payload
Undisclosed
Pertuzumab-ADC-Tb3-7 linker
[7]
Pertuzumab-ADC-Tb3-8
Pertuzumab-ADC-Tb3-8 payload
Undisclosed
Pertuzumab-ADC-Tb3-8 linker
[7]
Pertuzumab-ADC-Tb3-9
Pertuzumab-ADC-Tb3-9 payload
Undisclosed
Pertuzumab-ADC-Tb3-9 linker
[7]
Pertuzumab-ADC-Tb3-10
Pertuzumab-ADC-Tb3-10 payload
Undisclosed
Pertuzumab-ADC-Tb3-10 linker
[7]
Pertuzumab-Compound(la)
NeoDegrader P1
Protein cereblon (CRBN)
Pertuzumab-Compound(la) linker
[83]
Pertuzumab-Compound (la) DAR 8
NeoDegrader P1
Protein cereblon (CRBN)
Pertuzumab-Compound (la) DAR 8 linker
[83]
Pertuzumab-Compound(lc)
NeoDegrader P4
Protein cereblon (CRBN)
Pertuzumab-Compound(lc) linker
[83]
Pertuzumab-Compound (lc) DAR 8
NeoDegrader P4
Protein cereblon (CRBN)
Pertuzumab-Compound (lc) DAR 8 linker
[83]
Pertuzumab-Compound (le)
NeoDegrader P1
Protein cereblon (CRBN)
Pertuzumab-Compound (le) linker
[83]
Pertuzumab-Compound (lf)
NeoDegrader P6
Protein cereblon (CRBN)
Pertuzumab-Compound (lf) linker
[83]
Pertuzumab-Compound (lg)
NeoDegrader P2
Protein cereblon (CRBN)
Pertuzumab-Compound (lg) linker
[83]
Pertuzumab-Compound (lh)
NeoDegrader P13
Protein cereblon (CRBN)
Pertuzumab-Compound (lh) linker
[83]
Pertuzumab-Compound (li)
NeoDegrader P1
Protein cereblon (CRBN)
Pertuzumab-Compound (li) linker
[83]
Pertuzumab-Compound (lj)
NeoDegrader P1
Protein cereblon (CRBN)
Pertuzumab-Compound (lj) linker
[83]
Pertuzumab-Compound (lk)
NeoDegrader P14
Protein cereblon (CRBN)
Pertuzumab-Compound (lk) linker
[83]
Pertuzumab-Compound (ll)
NeoDegrader P14
Protein cereblon (CRBN)
Pertuzumab-Compound (ll) linker
[83]
Pertuzumab-Compound (lm)
NeoDegrader P14
Protein cereblon (CRBN)
Pertuzumab-Compound (lm) linker
[83]
Pertuzumab-Compound (X)
Pertuzumab-Compound (X) payload
Undisclosed
Pertuzumab-Compound (X) linker
[53]
Pertuzumab-Compound (XI)
Pertuzumab-Compound (XI) payload
Undisclosed
Pertuzumab-Compound (XI) linker
[53]
Pertuzumab-Compound (XIV)
Pertuzumab-Compound (XIV) payload
Undisclosed
Pertuzumab-Compound (XIV) linker
[53]
Pertuzumab-Compound (XVIII)
Pertuzumab-Compound (XVIII) payload
Undisclosed
Pertuzumab-Compound (XVIII) linker
[53]
Pertuzumab-Compound (Ie)
Pertuzumab-Compound (Ie) payload
Undisclosed
Pertuzumab-Compound (Ie) linker
[53]
Pertuzumab-Compound (XIX)
Pertuzumab-Compound (XIX) payload
Undisclosed
Pertuzumab-Compound (XIX) linker
[53]
Pertuzumab-Compound (Ii)
Pertuzumab-Compound (Ii) payload
Undisclosed
Pertuzumab-Compound (Ii) linker
[53]
Pertuzumab-Compound (XLI)
Pertuzumab-Compound (XLI) payload
Undisclosed
Pertuzumab-Compound (XLI) linker
[53]
Pertuzumab-Compound (XVI)
Pertuzumab-Compound (XIX) payload
Undisclosed
Pertuzumab-Compound (XIX) linker
[53]
Pertuzumab-Compound (XL)
Pertuzumab-Compound (XL) payload
Undisclosed
Pertuzumab-Compound (XL) linker
[53]
Pertuzumab-Compound (XLIII)
Pertuzumab-Compound (XLIII) payload
Undisclosed
Pertuzumab-Compound (XLIII) linker
[53]
Pertuzumab-Compound (XLII)
Pertuzumab-Compound (XLII) payload
Undisclosed
Pertuzumab-Compound (XLII) linker
[53]
Pertuzumab-Compound (XV)
Pertuzumab-Compound (XV) payload
Undisclosed
Pertuzumab-Compound (XV) linker
[53]
Pertuzumab-Compound 9
Mertansine DM1
Microtubule (MT)
Pertuzumab-Compound 9 linker
[23]
Pertuzumab-Compound 17
Mertansine DM4
Microtubule (MT)
Pertuzumab-Compound 17 linker
[23]
Pertuzumab-Compound 25
Monomethyl auristatin E
Microtubule (MT)
Pertuzumab-Compound 25 linker
[23]
Pertuzumab-Compound 31
Auristatin 0101
Microtubule (MT)
Pertuzumab-Compound 31 linker
[23]
Pertuzumab-Compound 36
Monomethyl auristatin E
Microtubule (MT)
Pertuzumab-Compound 36 linker
[23]
Pertuzumab-Compound 43
PBD dimer
Human Deoxyribonucleic acid (hDNA)
Pertuzumab-Compound 43 linker
[23]
Pertuzumab-Compound 49
PBD dimer
Human Deoxyribonucleic acid (hDNA)
Pertuzumab-Compound 49 linker
[23]
Pertuzumab-Compound 55
Mertansine DM1
Microtubule (MT)
Pertuzumab-Compound 55 linker
[23]
Pertuzumab-Compound 59
Mertansine DM4
Microtubule (MT)
Pertuzumab-Compound 59 linker
[23]
Pertuzumab-Compound 64
Monomethyl auristatin E
Microtubule (MT)
Pertuzumab-Compound 64 linker
[23]
Pertuzumab-Compound 69
Monomethyl auristatin E
Microtubule (MT)
Pertuzumab-Compound 69 linker
[23]
Pertuzumab-Compound 74
PBD dimer
Human Deoxyribonucleic acid (hDNA)
Pertuzumab-Compound 74 linker
[23]
Pertuzumab-Compound 75
Monomethyl auristatin E
Microtubule (MT)
Pertuzumab-Compound 75 linker
[23]
Pertuzumab-Compound 76
Monomethyl auristatin E
Microtubule (MT)
Pertuzumab-Compound 76 linker
[23]
Pertuzumab-Compound 77
Mertansine DM1
Microtubule (MT)
Pertuzumab-Compound 77 linker
[23]
Pertuzumab-Compound 78
Auristatin 0101
Microtubule (MT)
Pertuzumab-Compound 78 linker
[23]
Pertuzumab-Compound 79
Auristatin 0101
Microtubule (MT)
Pertuzumab-Compound 79 linker
[23]
Pertuzumab-Compound 80
Mertansine DM4
Microtubule (MT)
Pertuzumab-Compound 80 linker
[23]
Per-2C
Undisclosed
Undisclosed
Undisclosed
[84]
Per-5C
Undisclosed
Undisclosed
Undisclosed
[84]
WO2024169913A1 ADC07-01-8
B19
Eukaryotic peptide chain release factor GTP-binding subunit ERF3A (GSPT1)
Mc-Val-Cit-PABC
[86]
WO2024169913A1 ADC07-01-4
B19
Eukaryotic peptide chain release factor GTP-binding subunit ERF3A (GSPT1)
Mc-Val-Cit-PABC
[86]
WO2024169913A1 ADC07-02-8
B19
Eukaryotic peptide chain release factor GTP-binding subunit ERF3A (GSPT1)
Mc-Val-Ala-PABC
[86]
WO2024169913A1 ADC07-02-4
B19
Eukaryotic peptide chain release factor GTP-binding subunit ERF3A (GSPT1)
Mc-Val-Ala-PABC
[86]
WO2024169913A1 ADC07-06-8
B63
Eukaryotic peptide chain release factor GTP-binding subunit ERF3A (GSPT1)
Mc-Val-Ala-PABC
[86]
WO2024169913A1 ADC07-06-4
B63
Eukaryotic peptide chain release factor GTP-binding subunit ERF3A (GSPT1)
Mc-Val-Ala-PABC
[86]
WO2024169913A1 ADC07-08-8
B19
Eukaryotic peptide chain release factor GTP-binding subunit ERF3A (GSPT1)
(Linker-03)SMCC-TAZ-PEG-VC-PAB
[86]
WO2024169913A1 ADC07-08-4
B19
Eukaryotic peptide chain release factor GTP-binding subunit ERF3A (GSPT1)
(Linker-03)SMCC-TAZ-PEG-VC-PAB
[86]
WO2024169913A1 ADC07-09-8
Smol006
Eukaryotic peptide chain release factor GTP-binding subunit ERF3A (GSPT1)
Mc-Val-Cit-PABC
[86]
WO2024169913A1 ADC07-09-4
Smol006
Eukaryotic peptide chain release factor GTP-binding subunit ERF3A (GSPT1)
Mc-Val-Cit-PABC
[86]
pertuzumab
ADC Info ADC Name Payload Target Linker Ref
CN114306633A A-1
Monomethyl auristatin E
Microtubule (MT)
CN114306633A-A-1-linker
[85]
CN114306633A C-3
Monomethyl auristatin E
Microtubule (MT)
CN114306633A-C-3-linker
[85]
Pertuzumab-S239C
ADC Info ADC Name Payload Target Linker Ref
HER2-A Antibody-Compound (X)
HER2-A Antibody-Compound (X) payload
Undisclosed
HER2-A Antibody-Compound (X) linker
[53]
HER2-A Antibody-Compound (XI)
HER2-A Antibody-Compound (XI) payload
Undisclosed
HER2-A Antibody-Compound (XI) linker
[53]
HER2-A Antibody-Compound (XIV)
HER2-A Antibody-Compound (XIV) payload
Undisclosed
HER2-A Antibody-Compound (XIV) linker
[53]
HER2-A Antibody-Compound (XVIII)
HER2-A Antibody-Compound (XVIII) payload
Undisclosed
HER2-A Antibody-Compound (XVIII) linker
[53]
HER2-A Antibody-Compound (Ie)
HER2-A Antibody-Compound (Ie) payload
Undisclosed
HER2-A Antibody-Compound (Ie) linker
[53]
HER2-A Antibody-Compound (XIX)
HER2-A Antibody-Compound (XIX) payload
Undisclosed
HER2-A Antibody-Compound (XIX) linker
[53]
HER2-A Antibody-Compound (Ii)
HER2-A Antibody-Compound (Ii) payload
Undisclosed
HER2-A Antibody-Compound (Ii) linker
[53]
HER2-A Antibody-Compound (XLI)
HER2-A Antibody-Compound (XLI) payload
Undisclosed
HER2-A Antibody-Compound (XLI) linker
[53]
HER2-A Antibody-Compound (XVI)
HER2-A Antibody-Compound (XIX) payload
Undisclosed
HER2-A Antibody-Compound (XIX) linker
[53]
HER2-A Antibody-Compound (XL)
HER2-A Antibody-Compound (XL) payload
Undisclosed
HER2-A Antibody-Compound (XL) linker
[53]
HER2-A Antibody-Compound (XLIII)
HER2-A Antibody-Compound (XLIII) payload
Undisclosed
HER2-A Antibody-Compound (XLIII) linker
[53]
HER2-A Antibody-Compound (XLII)
HER2-A Antibody-Compound (XLII) payload
Undisclosed
HER2-A Antibody-Compound (XLII) linker
[53]
Pertuzumab-S239C-Compound (XV)
Pertuzumab-S239C-Compound (XV) payload
Undisclosed
Pertuzumab-S239C-Compound (XV) linker
[53]
ADC Info ADC Name Payload Target Linker Ref
Ptz-SA vedotin
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
[87]
Rat IgG2a mAb ICR12
ADC Info ADC Name Payload Target Linker Ref
Monoclonal antibody ICR12-CPG2 conjugate
Carboxypeptidase G2 (CPG2)
Undisclosed
Undisclosed
[88]
ADC Info ADC Name Payload Target Linker Ref
(RC48-vc-MMAE)
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Ala-PABC
[89]
Rituximab
ADC Info ADC Name Payload Target Linker Ref
CN119343374A ADC-RIT41C
Undisclosed
Undisclosed
Undisclosed
[90]
S1 Trastuzumab glycovariants
ADC Info ADC Name Payload Target Linker Ref
S1 Trastuzumab glycovariants ADC
Monomethyl auristatin E
Microtubule (MT)
DBCO-PEG4-Val-Cit
[91]
S4 Trastuzumab glycovariants
ADC Info ADC Name Payload Target Linker Ref
S4 Trastuzumab glycovariants ADC
Monomethyl auristatin E
Microtubule (MT)
DBCO-PEG4-Val-Cit
[91]
S6 Trastuzumab glycovariants
ADC Info ADC Name Payload Target Linker Ref
S6 Trastuzumab glycovariants ADC
Monomethyl auristatin E
Microtubule (MT)
DBCO-PEG4-Val-Cit
[91]
Sacituzumab
ADC Info ADC Name Payload Target Linker Ref
Anti-Her2- (Q295-mcValCitPABC-A6)- (mcMMAF)
Monomethyl auristatin F
Microtubule (MT)
Undisclosed
[92]
Anti-Her2- (0295-mcA6)- (mcMMAF)
Monomethyl auristatin F
Microtubule (MT)
Undisclosed
[92]
Anti-Her2- (0295-mcMMAF)- (mcValCitPABC-A6)
Monomethyl auristatin F
Microtubule (MT)
Undisclosed
[92]
Anti-Her2- (0295-mcMMAF)- (mc-A6)
Monomethyl auristatin F
Microtubule (MT)
Undisclosed
[92]
Her2-Saci- (mc-MMAF)- (McAsnAsn-A6)
Monomethyl auristatin F
Microtubule (MT)
Undisclosed
[92]
Her2-Saci- (mc-MMAF)- (mc-A6)
Monomethyl auristatin F
Microtubule (MT)
Undisclosed
[92]
SCAHer2 (1)xSCAHer (2)
ADC Info ADC Name Payload Target Linker Ref
CN117337196A Compound88
Active metabolite of irinotecan SN38
DNA topoisomerase 1 (TOP1)
30kmPEG-Lys (PEG2 - Mal)-3 (Val-Cit-PAB-DEA)
[93]
SCAHer2 (1)xSCAHer2
ADC Info ADC Name Payload Target Linker Ref
CN117337196A Compound86
Active metabolite of irinotecan SN38
DNA topoisomerase 1 (TOP1)
30kmPEG-Lys (PEG2 - Mal)-2 (Val-Cit-PAB-DEA)
[93]
T (kK183C+K290C)
ADC Info ADC Name Payload Target Linker Ref
T (kK183C+K290C)-VC0101 ADC
Auristatin 0101
Microtubule (MT)
Mc-Val-Cit-PABC
[94]
TCO-trastuzumab trast-v1a-XL11
ADC Info ADC Name Payload Target Linker Ref
Trast-v1a-XL11-204
Undisclosed
Undisclosed
Undisclosed
[41]
Thio Anti-HER2 hu7C2 HC L177C
ADC Info ADC Name Payload Target Linker Ref
WO2017059289A1 ADC-117
WO2017059289A1_ADC-117 payload
Undisclosed
WO2017059289A1_ADC-117 linker
[95]
Thio Anti-HER2 hu7C2 HC Y376C
ADC Info ADC Name Payload Target Linker Ref
WO2017059289A1 ADC-119
WO2017059289A1_ADC-119 payload
Undisclosed
WO2017059289A1_ADC-119 linker
[95]
Thio Anti-HER2 hu7C2 LC K149C
ADC Info ADC Name Payload Target Linker Ref
WO2017059289A1 ADC-101
WO2017059289A1_ADC-101 payload
Undisclosed
WO2017059289A1_ADC-101 linker
[95]
WO2017059289A1 ADC-102
WO2017059289A1_ADC-102 payload
Undisclosed
WO2017059289A1_ADC-102 linker
[95]
WO2017059289A1 ADC-104
WO2017059289A1_ADC-104 payload
Undisclosed
WO2017059289A1_ADC-104 linker
[95]
WO2017059289A1 ADC-106
WO2017059289A1_ADC-106 payload
Undisclosed
WO2017059289A1_ADC-106 linker
[95]
WO2017059289A1 ADC-108
WO2017059289A1_ADC-108 payload
Undisclosed
WO2017059289A1_ADC-108 linker
[95]
WO2017059289A1 ADC-109
WO2017059289A1_ADC-109 payload
Undisclosed
WO2017059289A1_ADC-109 linker
[95]
WO2017059289A1 ADC-201
WO2017059289A1_ADC-201 payload
Undisclosed
WO2017059289A1_ADC-201 linker
[95]
WO2017059289A1 ADC-203
WO2017059289A1_ADC-203 payload
Undisclosed
WO2017059289A1_ADC-203 linker
[95]
WO2017059289A1 ADC-205
WO2017059289A1_ADC-205 payload
Undisclosed
WO2017059289A1_ADC-205 linker
[95]
Thio Anti-HER2 hu7C2 LC K149C HC L177C
ADC Info ADC Name Payload Target Linker Ref
WO2017059289A1 ADC-113
WO2017059289A1_ADC-113 payload
Undisclosed
WO2017059289A1_ADC-113 linker
[95]
Thio Anti-HER2 hu7C2 LC K149C HC L177C HC Y376C
ADC Info ADC Name Payload Target Linker Ref
WO2017059289A1 ADC-114
WO2017059289A1_ADC-114 payload
Undisclosed
WO2017059289A1_ADC-114 linker
[95]
Thio Her2 7C2 HC:A140C
ADC Info ADC Name Payload Target Linker Ref
CN118436801A PAC 5
undisclosed
Undisclosed
Mc-Val-Cit-PABC
[96]
Thio hu Anti-HER2 4D5-8 HC A118C
ADC Info ADC Name Payload Target Linker Ref
WO2014159981A2 ADC-211
WO2014159981A2_ADC-211 payload
Undisclosed
WO2014159981A2_ADC-211 linker
[97]
WO2014159981A2 ADC-130
WO2014159981A2_ADC-130 payload
Undisclosed
WO2014159981A2_ADC-130 linker
[97]
WO2014159981A2 ADC-HER2-48
WO2014159981A2_ADC-HER2-48 payload
Undisclosed
WO2014159981A2_ADC-HER2-48 linker
[97]
WO2014159981A2 ADC-HER2-22
WO2014159981A2_ADC-HER2-22 payload
Undisclosed
WO2014159981A2_ADC-HER2-22 linker
[97]
Thio hu Anti-HER2 7C2 HC A140C
ADC Info ADC Name Payload Target Linker Ref
WO2017214024A1 ADC-106
WO2017214024A1_ADC-106 payload
Undisclosed
WO2017214024A1_ADC-106 linker
[98]
Thio hu Anti-HER2 7C2 LC K149C
ADC Info ADC Name Payload Target Linker Ref
WO2017214024A1 ADC-103
WO2017214024A1_ADC-103 payload
Undisclosed
WO2017214024A1_ADC-103 linker
[98]
Thio Hu Anti-Her2 7C2 LC K149C
ADC Info ADC Name Payload Target Linker Ref
CN118436801A PAC 1
undisclosed
Undisclosed
Mc-Val-Cit-PABC
[96]
Thio Hu anti-Her2 7C2 LC:K149C
ADC Info ADC Name Payload Target Linker Ref
CN118436801A PAC 3
undisclosed
Undisclosed
Mc-Val-Cit-PABC
[96]
Thio-Tmab
ADC Info ADC Name Payload Target Linker Ref
Thio-Tmab-BMPEO-DM1
Maytansinoid DM1
Microtubule (MT)
Thio-Tmab-BMPEO-DM1 linker
[14]
Thio-Tr (A121C)
ADC Info ADC Name Payload Target Linker Ref
Thio-Tr (A121C)-BMPEO-DM1
Maytansinoid DM1
Microtubule (MT)
Thio-Tr (A121C)-BMPEO-DM1 linker
[14]
Tigatuzumab
ADC Info ADC Name Payload Target Linker Ref
Tigatuzumab-ADC-Tb3-1
Tigatuzumab-ADC-Tb3-1 payload
Undisclosed
Tigatuzumab-ADC-Tb3-1 linker
[7]
Tigatuzumab-ADC-Tb3-2
Tigatuzumab-ADC-Tb3-2 payload
Undisclosed
Tigatuzumab-ADC-Tb3-2 linker
[7]
Tigatuzumab-ADC-Tb3-3
Tigatuzumab-ADC-Tb3-3 payload
Undisclosed
Tigatuzumab-ADC-Tb3-3 linker
[7]
Tigatuzumab-ADC-Tb3-4
Tigatuzumab-ADC-Tb3-4 payload
Undisclosed
Tigatuzumab-ADC-Tb3-4 linker
[7]
Tigatuzumab-ADC-Tb3-5
Tigatuzumab-ADC-Tb3-5 payload
Undisclosed
Tigatuzumab-ADC-Tb3-5 linker
[7]
Tigatuzumab-ADC-Tb3-6
Tigatuzumab-ADC-Tb3-6 payload
Undisclosed
Tigatuzumab-ADC-Tb3-6 linker
[7]
Tigatuzumab-ADC-Tb3-7
Tigatuzumab-ADC-Tb3-7 payload
Undisclosed
Tigatuzumab-ADC-Tb3-7 linker
[7]
Tigatuzumab-ADC-Tb3-8
Tigatuzumab-ADC-Tb3-8 payload
Undisclosed
Tigatuzumab-ADC-Tb3-8 linker
[7]
Tigatuzumab-ADC-Tb3-9
Tigatuzumab-ADC-Tb3-9 payload
Undisclosed
Tigatuzumab-ADC-Tb3-9 linker
[7]
Tigatuzumab-ADC-Tb3-10
Tigatuzumab-ADC-Tb3-10 payload
Undisclosed
Tigatuzumab-ADC-Tb3-10 linker
[7]
ADC Info ADC Name Payload Target Linker Ref
WO2024105206A1 30e-1015 1
Undisclosed
Undisclosed
Undisclosed
[99]
WO2024105206A1 32e-1015 1
Undisclosed
Undisclosed
Undisclosed
[99]
WO2024105206A1 30e-1015 2
22i-5657 Payload
Undisclosed
22i-5657 Linker
[99]
WO2024105206A1 32e-1015 2
Mdo-cpt
DNA topoisomerase I (TOP1)
32p-Avelu Linker
[99]
ADC Info ADC Name Payload Target Linker Ref
Tra-CAST-MMAE
Monomethyl auristatin E
Microtubule (MT)
Styrylboronic acid-Val-Cit-PAB
[100]
ADC Info ADC Name Payload Target Linker Ref
Tras-VC-MMAE
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
[101]
trast-v1b
ADC Info ADC Name Payload Target Linker Ref
Trast-v1b- (PF07)2
Undisclosed
Undisclosed
Undisclosed
[41]
Trast-v1b- (PF15)2
Undisclosed
Undisclosed
Undisclosed
[41]
ADC Info ADC Name Payload Target Linker Ref
Trast-v2- (PF15)2
Undisclosed
Undisclosed
Undisclosed
[41]
ADC Info ADC Name Payload Target Linker Ref
Trast-v3- (PF15)2
Undisclosed
Undisclosed
Undisclosed
[41]
Trast-v3- (PF07)2
Undisclosed
Undisclosed
Undisclosed
[41]
Trast-v3-PF27
Undisclosed
Undisclosed
Undisclosed
[41]
Trast-v3-PF22
Undisclosed
Undisclosed
Undisclosed
[41]
Trast-v3- (201)2
Undisclosed
Undisclosed
Undisclosed
[41]
trast-v5a
ADC Info ADC Name Payload Target Linker Ref
Trast-v5b- (PF16)2
Undisclosed
Undisclosed
Undisclosed
[41]
Trast-v5b-PF28
Undisclosed
Undisclosed
Undisclosed
[41]
trast-v5b- (XL05)2
ADC Info ADC Name Payload Target Linker Ref
Trast-v5b- (XL05-PF09)2
Undisclosed
Undisclosed
Undisclosed
[41]
trast-v5b-XL01
ADC Info ADC Name Payload Target Linker Ref
Trast-v5b-XL01-PF19
Undisclosed
Undisclosed
Undisclosed
[41]
Trast-v5b-XL01-PF02
Undisclosed
Undisclosed
Undisclosed
[41]
Trast-v5b-XL01-PF09
Undisclosed
Undisclosed
Undisclosed
[41]
trast-v5b-XL02
ADC Info ADC Name Payload Target Linker Ref
Trast-v5b-XL02-PF15
Undisclosed
Undisclosed
Undisclosed
[41]
trast-v5b-XL05
ADC Info ADC Name Payload Target Linker Ref
Trast-v5b- (XL05)2 1
Undisclosed
Undisclosed
Undisclosed
[41]
Trast-v5b- (XL05-PF02)2
Undisclosed
Undisclosed
Undisclosed
[41]
ADC Info ADC Name Payload Target Linker Ref
Trast-v6- (XL05-PF19)2
Undisclosed
Undisclosed
Undisclosed
[41]
Trast-v6- (PF16)2
Undisclosed
Undisclosed
Undisclosed
[41]
Trast-v6-PF28
Undisclosed
Undisclosed
Undisclosed
[41]
Trast-v6- (XL05)2
ADC Info ADC Name Payload Target Linker Ref
Trast-v6- (XL05-PF02)2
Undisclosed
Undisclosed
Undisclosed
[41]
Trast-v6- (XL05-PF09)2
Undisclosed
Undisclosed
Undisclosed
[41]
trast-v6-XL01
ADC Info ADC Name Payload Target Linker Ref
Trast-v6-XL01-PF19 1
Undisclosed
Undisclosed
Undisclosed
[41]
Trast-v6-XL01-PF02
Undisclosed
Undisclosed
Undisclosed
[41]
Trast-v6-XL01-PF09
Undisclosed
Undisclosed
Undisclosed
[41]
trast-v6-XL02
ADC Info ADC Name Payload Target Linker Ref
Trast-v6-XL02-PF15
Undisclosed
Undisclosed
Undisclosed
[41]
trast-v6-XL03
ADC Info ADC Name Payload Target Linker Ref
Trast-v6-XL03-PF15
Undisclosed
Undisclosed
Undisclosed
[41]
trast-v6-XL12
ADC Info ADC Name Payload Target Linker Ref
Trast-v6-XL12-PF02
Undisclosed
Undisclosed
Undisclosed
[41]
Trast-v7-XL01
ADC Info ADC Name Payload Target Linker Ref
Trast-v6-XL01-PF19 2
Undisclosed
Undisclosed
Undisclosed
[41]
trast-v7-XL01
ADC Info ADC Name Payload Target Linker Ref
Trast-v7-XL01-PF02
Undisclosed
Undisclosed
Undisclosed
[41]
Trast-v7-XL01-PF09
Undisclosed
Undisclosed
Undisclosed
[41]
trast-v8-XL06
ADC Info ADC Name Payload Target Linker Ref
Trast-v8-XL06-PF02
Undisclosed
Undisclosed
Undisclosed
[41]
Trast-v8-XL06-PF09
Undisclosed
Undisclosed
Undisclosed
[41]
ADC Info ADC Name Payload Target Linker Ref
Trast-v9- (PF19)2,
Undisclosed
Undisclosed
Undisclosed
[41]
Trastuzumab
ADC Info ADC Name Payload Target Linker Ref
TAA-013
Mertansine DM1
Microtubule (MT)
Succinimidyl-4- (N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
B-003
Mertansine DM1
Microtubule (MT)
Succinimidyl-4- (N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
SHR-A1201
Mertansine DM1
Microtubule (MT)
Succinimidyl-4- (N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
BI-CON-02
Undisclosed
Undisclosed
Undisclosed
T-PBA
PBD-based payload 37b3
Human Deoxyribonucleic acid (hDNA)
Mc-Val-Ala
[102]
Trastuzumab-SYNtansine
Ahx-maytansine
Microtubule (MT)
BCN-HydraSpace-Val-Cit-PABC
[103]
Trastuzumab-Gelonin
Gelonin
Ribosome (RB)
N-succinimidyl 4-(2-pyridyldithio) butanoate (SPDB)
[104]
Anti-HER2_vc-1
TLR7 agonist-1
Toll-like receptor 7 (TLR7)
Mc-Val-Cit-PABC
[105]
Tmab-SPP-DM1
Mertansine DM1
Microtubule (MT)
N-succinimidyl 4-(2-pyridyldithio) pentanoate (SPP)
[106]
Tmab-SSNPP-DM3
Maytansinoid DM3
Microtubule (MT)
Sulfosuccinimidyl-N-succinimidyl-4-(5-nitro-2-pyridyldithio) pentanoate (SSNPP)
[106]
Tmab-SSNPP-DM4
Mertansine DM4
Microtubule (MT)
Sulfosuccinimidyl-N-succinimidyl-4-(5-nitro-2-pyridyldithio) pentanoate (SSNPP)
[106]
Trastuzumab-AJICAP-maytansinoid
Mertansine DM1
Microtubule (MT)
AJICAP
[107]
Trastuzumab-C239I-SG3249
SG3199
Human Deoxyribonucleic acid (hDNA)
Mal-PEG8-Val-Ala-PABC
[108]
Tras-Gly5-EDA-Pnu
PNU-159682
DNA topoisomerase 2-alpha (TOP2A)
Gly5-EDA
[109]
Trastuzumab DVD-ADC
Monomethyl auristatin F
Microtubule (MT)
Hexapeptide linker ASTKGP
[110]
Trastuzumab-Man-beta-1,4GlcNAc-MMAE
Monomethyl auristatin E
Microtubule (MT)
Man-beta-1,4-GlcNAc
[111]
Trastuzumab-Glc-beta-1,4GlcNAc-MMAE
Monomethyl auristatin E
Microtubule (MT)
Glc-beta-1,4GlcNAc
[111]
Trastuzumab-Gal-beta-1,4GlcNAc-MMAE
Monomethyl auristatin E
Microtubule (MT)
Gal-beta-1,4-GlcNAc
[111]
Trastuzumab-MMAE conjugate DAR2
Monomethyl auristatin E
Microtubule (MT)
Man-beta-1,4-GlcNAc-DBCO-PEG5-VC-PAB
[112]
Trastuzumab-MMAE conjugate DAR4
Monomethyl auristatin E
Microtubule (MT)
Man-beta-1,4-GlcNAc-DBCO-PEG5-VC-PAB
[112]
Trastuzumab-MMAE conjugate DAR6
Monomethyl auristatin E
Microtubule (MT)
Man-beta-1,4-GlcNAc-DBCO-PEG5-VC-PAB
[112]
Trastuzumab-MMAE conjugate DAR8
Monomethyl auristatin E
Microtubule (MT)
Man-beta-1,4-GlcNAc-DBCO-PEG5-VC-PAB
[112]
Trastuzumab-MMAE conjugate DAR12
Monomethyl auristatin E
Microtubule (MT)
Man-beta-1,4-GlcNAc-DBCO-PEG5-VC-PAB
[112]
Trastuzumab-RSL3-NH2
RSL3-NH2
Phospholipid hydroperoxide glutathione peroxidase (GPX4)
Mal-PEG4-DBCO-Ala-Val
[113]
Tras-Gly5-EDA-Dox
Doxorubicin
DNA topoisomerase 2-alpha (TOP2A)
Gly5-EDA
[109]
Tras-Gly5-EDA-Nemo
Nemorubicin
DNA topoisomerase 2-alpha (TOP2A)
Gly5-EDA
[109]
Tras-Gly3-Vakl-Cit-PAB-PNU-159682
PNU-159682
DNA topoisomerase 2-alpha (TOP2A)
Gly3-vcPAB
[109]
Tras-Gly5-May
Mertansine DM1
Microtubule (MT)
Gly5
[109]
Trastuzumab-SG3227
SG2219
Human Deoxyribonucleic acid (hDNA)
Acetamide-PEG4-Val-Ala-PABA
[48]
HER-SG3249
SG3199
Human Deoxyribonucleic acid (hDNA)
Mal-PEG8-Val-Ala-PABC
[114]
Site-specific HER-SG3249
SG3199
Human Deoxyribonucleic acid (hDNA)
Mal-PEG8-Val-Ala-PABC
[114]
Trastuzumab-SG3600 high DAR
N10-beta-glucuronide SG3200
Human Deoxyribonucleic acid (hDNA)
Mal-PEG8-Val-Ala-PABC
[47]
LIN-002
Undisclosed
Undisclosed
Undisclosed
[115]
Trastuzumab-BCN-HydraSpace-Val-Cit-PABC-Gly-Calicheamicin
Gly-calicheamicin
Human Deoxyribonucleic acid (hDNA)
BCN-HydraSpace-Val-Cit-PABC
[103]
HER2 targeted DEP conjugate
Active metabolite of irinotecan SN38
DNA topoisomerase 1 (TOP1)
Undisclosed
[116]
Trastuzumab SG-3259
SG3312
Human Deoxyribonucleic acid (hDNA)
Mc-Val-Ala
[117]
Trastuzumab-SG3400 high DAR
SG3200
Human Deoxyribonucleic acid (hDNA)
Mal-PEG8-Val-Ala-PABC
[47]
Tra-IR700
IRDye 700DX
Undisclosed
Undisclosed
[118]
Anti-HER2_vc-7
TLR7 agonist-7
Toll-like receptor 7 (TLR7)
Mc-Val-Cit-PABC
[105]
Anti-HER2_vc-2
TLR7 agonist-2
Toll-like receptor 7 (TLR7)
Mc-Val-Cit-PABC
[105]
Anti-HER2 antibody-drug conjugate (Spirea)
Monomethyl auristatin E
Microtubule (MT)
Undisclosed
[119]
TTZ-Mc-NPV-MMAE
Monomethyl auristatin E
Microtubule (MT)
Mc-Asn-Pro-Val-PABC
[120]
Adcitmer
Monomethyl auristatin E
Microtubule (MT)
Pyridino-caproic-Val-Cit-PABC
[121]
Trastuzumab-BCN-HydraSpace-Val-Cit-PABC-MMAE
Monomethyl auristatin E
Microtubule (MT)
BCN-HydraSpace-Val-Cit-PABC
[103]
MF-TTZ-MMAE
Monomethyl auristatin E
Microtubule (MT)
Dibromomethyl pyridine-Val-Cit-PABC
[122]
FGM-TTZ-MMAE
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
[122]
NC-ADC
Monomethyl auristatin E
Microtubule (MT)
Divinylpyrimidine-PEG4
[123]
C-ADC
Monomethyl auristatin E
Microtubule (MT)
Divinylpyrimidine-PEG4-Val-Ala-PABC
[123]
Tmab-SPDP-DM1
Mertansine DM1
Microtubule (MT)
N-succinimidyl 4-(2-pyridyldithio) butanoate (SPDB)
[106]
T-K-F (DAR 3.9)
Monomethyl auristatin F
Microtubule (MT)
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
[124]
T-C-F (DAR 3.7)
Monomethyl auristatin F
Microtubule (MT)
Maleimido-caproyl
[124]
Trastuzumab-PNU-159682 Antibody-Drug Conjugate
PNU-159682
DNA topoisomerase 2-alpha (TOP2A)
Undisclosed
[125]
Trastuzumab-BCN-HydraSpace-Val-Cit-PABC-PNU-159682
PNU-159682
DNA topoisomerase 2-alpha (TOP2A)
BCN-HydraSpace-Val-Cit-PABC
[126]
Trastuzumab-G5-PNU
PNU-159682
DNA topoisomerase 2-alpha (TOP2A)
Gly5-FITC
[109]
PRO-1102
Exatecan
DNA topoisomerase 1 (TOP1)
Cleavable hydrophilic linker
[127]
Tra-Exa-PSAR10
Exatecan
DNA topoisomerase 1 (TOP1)
Mal-Exa-PSAR10
[128]
Tra-Exa-PSAR0
Exatecan
DNA topoisomerase 1 (TOP1)
Mal-Exa-PSAR0
[128]
T-N-F (DAR 3.2)
Aldehyde-tagged MMAF
Microtubule (MT)
Undisclosed
[124]
T-N-F (DAR 1.6)
Aldehyde-tagged MMAF
Microtubule (MT)
Undisclosed
[124]
Tras-ALN
Alendronate
Farnesyl pyrophosphate synthase (FDPS)
Bicyclo[6.1.0]nona-4-yne
[129]
Trastuzumab-ATAC
Alpha-amanitin
DNA-directed RNA polymerase II subunit RPB2 (POLR2B); DNA-directed RNA polymerase III subunit RPC7 (POLR3G)
Undisclosed
[130]
CRD-5500 antibody-drug conjugate
CRD5500
Stimulator of interferon genes protein (STING1)
Undisclosed
[131]
Trastuzumab-deBouganin
DeBouganin
Microtubule (MT)
Undisclosed
[132]
Trastuzumab-BCN-HydraSpace-Val-Cit-PABC-Duocarmycin
Duocarmycin Sa
Human Deoxyribonucleic acid (hDNA)
BCN-HydraSpace-Val-Cit-PABC
[103]
Trastuzumab-BCN-HydraSpace-Val-Cit-PABC-Calicheamicin
N-acetyl-gamma-calicheamicin
Human Deoxyribonucleic acid (hDNA)
BCN-HydraSpace-Val-Cit-PABC
[103]
MYX2449
N-Myristolytransferase inhibitor (NMTi)
Glycylpeptide N-tetradecanoyltransferase 1 (NMT1)
Undisclosed
[133]
Trastuzumab-BCN-HydraSpace-Val-Ala-PABC-PBD dimer
PBD dimer 2
Human Deoxyribonucleic acid (hDNA)
BCN-HydraSpace-Val-Ala-PABC
[103]
MI-130004
PM050489
Microtubule (MT)
6-(2,5-dioxopyrrol-1-yl)-N-Propylhexanamide
[134]
Trastuzumab-DNA mimic 4
Q Pho-DNA mimics
Human Deoxyribonucleic acid (hDNA)
Diphenyltio-Mal-Cap
[135]
ST8176AA1
ST7612AA1
Histone deacetylase 1 (HDAC1)
Maleimide-thiol linker
[136]
Trastuzumab-L3-TL
Triptolide
Nuclear factor NF-kappa-B p105 subunit (NFKB1)
BVP-PEG3-carbamate-PEG4
[137]
Trastuzumab-L2-TL
Triptolide
Nuclear factor NF-kappa-B p105 subunit (NFKB1)
BVP-PEG3-diamine
[137]
Trastuzumab-L1-TL
Triptolide
Nuclear factor NF-kappa-B p105 subunit (NFKB1)
BVP-PEG3-carbamate
[137]
Trastuzumab-L6
MF-6
DNA topoisomerase 1 (TOP1)
Bridged PEG4-valine-alanine
[138]
ADC Trast-7
Monomethyl auristatin E
Microtubule (MT)
Undisclosed
[139]
ADC Trast-10
Monomethyl auristatin E
Microtubule (MT)
Bis-BCN-modified Val-Cit-PABC linker 10
[139]
ADC Trast-14
PBD dimer 3
Human Deoxyribonucleic acid (hDNA)
Undisclosed
[139]
ADC Trast-11
PBD dimer 3
Human Deoxyribonucleic acid (hDNA)
Bis-BCN-modified Val-Cit-PABC linker 10
[139]
Trastuzumab-MCC-CpG conjugate
Differentiated TLR-9 agonist (T-CpG)
Toll-like receptor 9 (TLR9)
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
[140]
Trastuzumab-T1000-exatecan
Exatecan
DNA topoisomerase 1 (TOP1)
Undisclosed
[141]
Trastuzumab-NGM-PROTAC conjugate
BRD4 PROTAC 3
Bromodomain-containing protein 4 (BRD4)
NGM based linker
[142]
Trastuzumab-iCME
Membrane-impermable colchinolmethyl ether (iCME) cytotoxin
Microtubule (MT)
Pacific blue fluorophore-SH based linker
[143]
IgG1 (trastuzumab)-vc-MMAE
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
[19]
Trastuzumab-DNA conjugate
DNA mimics
Human Deoxyribonucleic acid (hDNA)
Undisclosed
[144]
OHPAS ADC-1
Alpha-amanitin
DNA-directed RNA polymerase II subunit RPB2 (POLR2B); DNA-directed RNA polymerase III subunit RPC7 (POLR3G)
Ortho-hydroxy-protected aryl sulfate
[145]
OHPAS ADC-2
SG2000
Human Deoxyribonucleic acid (hDNA)
Ortho-hydroxy-protected aryl sulfate
[145]
OHPAS ADC-3
seco-CBI-indole
Human Deoxyribonucleic acid (hDNA)
Ortho-hydroxy-protected aryl sulfate
[145]
OHPAS ADC-4
CBI-dimer-beta-Gal
Human Deoxyribonucleic acid (hDNA)
Ortho-hydroxy-protected aryl sulfate
[145]
Trastuzumab/nab-paclitaxel
Paclitaxel
Microtubule (MT)
Undisclosed
[146]
Docetaxel-trastuzumab
Docetaxel
Microtubule (MT)
Undisclosed
[147]
Trastuzumab-PC4AP-DOX
Doxorubicin
DNA topoisomerase 2-alpha (TOP2A)
Photocaged C4AP
[148]
Trastuzumab-PNUEDAGly5
PNU-159682
DNA topoisomerase 2-alpha (TOP2A)
LPETG-Gly5-EDA
[149]
T (Anti-HER2)-30.2060
Amanitin 30.206
DNA-directed RNA polymerase II subunit RPB2 (POLR2B); DNA-directed RNA polymerase III subunit RPC7 (POLR3G)
Mc-Val-Ala-PABC
[31]
T (Anti-HER2)-30.2867
Amanitin 30.2867
DNA-directed RNA polymerase II subunit RPB2 (POLR2B); DNA-directed RNA polymerase III subunit RPC7 (POLR3G)
Maleimido-caproyl
[31]
ADC2-2
ADC 2-2 payload
DNA topoisomerase 1 (TOP1)
ADC 2-2 linker
[150]
ADC2-4
ADC 2-4 payload
DNA topoisomerase 1 (TOP1)
ADC 2-4 linker
[150]
ADC2-6-2
ADC 2-6-2 payload
DNA topoisomerase 1 (TOP1)
ADC 2-6-2 linker
[150]
ADC2-7-2
ADC 2-7-2 payload
DNA topoisomerase 1 (TOP1)
ADC 2-7-2 linker
[150]
ADC2-9-1
ADC 2-9-1 payload
DNA topoisomerase 1 (TOP1)
ADC 2-9-1 linker
[150]
ADC2-9-2
ADC 2-9-2 payload
DNA topoisomerase 1 (TOP1)
ADC 2-9-2 linker
[150]
ADC2-10
ADC 2-10 payload
DNA topoisomerase 1 (TOP1)
ADC 2-10 linker
[150]
ADC2-11
ADC 2-11 payload
DNA topoisomerase 1 (TOP1)
ADC 2-11 linker
[150]
ADC2-22
ADC 2-22 payload
DNA topoisomerase 1 (TOP1)
ADC 2-22 linker
[150]
ADC2-23
ADC 2-23 payload
DNA topoisomerase 1 (TOP1)
ADC 2-23 linker
[150]
ADC2-24
ADC 2-24 payload
DNA topoisomerase 1 (TOP1)
ADC 2-24 linker
[150]
ADC2-25
ADC 2-25 payload
DNA topoisomerase 1 (TOP1)
ADC 2-25 linker
[150]
ADC2-26
ADC 2-26 payload
DNA topoisomerase 1 (TOP1)
ADC 2-26 linker
[150]
ADC2-27
ADC 2-27 payload
DNA topoisomerase 1 (TOP1)
ADC 2-27 linker
[150]
ADC2-29
ADC 2-29 payload
DNA topoisomerase 1 (TOP1)
ADC 2-29 linker
[150]
ADC2-30
ADC 2-30 payload
DNA topoisomerase 1 (TOP1)
ADC 2-30 linker
[150]
ADC2-31
ADC 2-31 payload
DNA topoisomerase 1 (TOP1)
ADC 2-31 linker
[150]
ADC2-32
ADC 2-32 payload
DNA topoisomerase 1 (TOP1)
ADC 2-32 linker
[150]
ADC2-33
ADC 2-33 payload
DNA topoisomerase 1 (TOP1)
ADC 2-33 linker
[150]
ADC2-34
ADC 2-34 payload
DNA topoisomerase 1 (TOP1)
ADC 2-34 linker
[150]
ADC2-35
ADC 2-35 payload
DNA topoisomerase 1 (TOP1)
ADC 2-35 linker
[150]
ADC2-36-1
ADC 2-36-1 payload
DNA topoisomerase 1 (TOP1)
ADC 2-36-1 linker
[150]
ADC2-36-2
ADC 2-36-2 payload
DNA topoisomerase 1 (TOP1)
ADC 2-36-2 linker
[150]
ADC2-37
ADC 2-37 payload
DNA topoisomerase 1 (TOP1)
ADC 2-37 linker
[150]
ADC2-38
ADC 2-38 payload
DNA topoisomerase 1 (TOP1)
ADC 2-38 linker
[150]
ADC2-39
ADC 2-39 payload
DNA topoisomerase 1 (TOP1)
ADC 2-39 linker
[150]
ADC2-40
ADC 2-40 payload
DNA topoisomerase 1 (TOP1)
ADC 2-40 linker
[150]
ADC2-41
ADC 2-41 payload
DNA topoisomerase 1 (TOP1)
ADC 2-41 linker
[150]
ADC2-42
ADC 2-42 payload
DNA topoisomerase 1 (TOP1)
ADC 2-42 linker
[150]
ADC2-42-RO
ADC 2-42-RO payload
DNA topoisomerase 1 (TOP1)
ADC 2-42-RO linker
[150]
ADC2-43
ADC 2-43 payload
DNA topoisomerase 1 (TOP1)
ADC 2-43 linker
[150]
ADC2-44
ADC 2-44 payload
DNA topoisomerase 1 (TOP1)
ADC 2-44 linker
[150]
ADC2-45
ADC 2-45 payload
DNA topoisomerase 1 (TOP1)
ADC 2-45 linker
[150]
ADC2-46
ADC 2-46 payload
DNA topoisomerase 1 (TOP1)
ADC 2-46 linker
[150]
ADC2-47
ADC 2-47 payload
DNA topoisomerase 1 (TOP1)
ADC 2-47 linker
[150]
ADC2-48
ADC 2-48 payload
DNA topoisomerase 1 (TOP1)
ADC 2-48 linker
[150]
ADC2-49
ADC 2-49 payload
DNA topoisomerase 1 (TOP1)
ADC 2-49 linker
[150]
ADC2-50
ADC 2-50 payload
DNA topoisomerase 1 (TOP1)
ADC 2-50 linker
[150]
ADC2-51
ADC 2-51 payload
DNA topoisomerase 1 (TOP1)
ADC 2-51 linker
[150]
ADC2-53
ADC 2-53 payload
DNA topoisomerase 1 (TOP1)
ADC 2-53 linker
[150]
ADC2-54
ADC 2-54 payload
DNA topoisomerase 1 (TOP1)
ADC 2-54 linker
[150]
ADC2-55
ADC 2-55 payload
DNA topoisomerase 1 (TOP1)
ADC 2-55 linker
[150]
ADC2-56
ADC 2-56 payload
DNA topoisomerase 1 (TOP1)
ADC 2-56 linker
[150]
ADC2-57
ADC 2-57 payload
DNA topoisomerase 1 (TOP1)
ADC 2-57 linker
[150]
ADC2-58
ADC 2-58 payload
DNA topoisomerase 1 (TOP1)
ADC 2-58 linker
[150]
ADC2-59
ADC 2-59 payload
DNA topoisomerase 1 (TOP1)
ADC 2-59 linker
[150]
ADC2-60
ADC 2-60 payload
DNA topoisomerase 1 (TOP1)
ADC 2-60 linker
[150]
ADC2-61
ADC 2-61 payload
DNA topoisomerase 1 (TOP1)
ADC 2-61 linker
[150]
ADC-2-62-1
ADC 2-62-1 payload
DNA topoisomerase 1 (TOP1)
ADC 2-62-1 linker
[150]
ADC-2-62-2
ADC 2-62-2 payload
DNA topoisomerase 1 (TOP1)
ADC 2-62-2 linker
[150]
ADC-2-63-1
ADC 2-63-1 payload
DNA topoisomerase 1 (TOP1)
ADC 2-63-1 linker
[150]
ADC-2-63-2
ADC 2-63-2 payload
DNA topoisomerase 1 (TOP1)
ADC 2-63-2 linker
[150]
ADC-2-64-1
ADC 2-64-1 payload
DNA topoisomerase 1 (TOP1)
ADC 2-64-1 linker
[150]
ADC-2-64-2
ADC 2-64-2 payload
DNA topoisomerase 1 (TOP1)
ADC 2-64-2 linker
[150]
ADC-2-65-1
ADC 2-65-1 payload
DNA topoisomerase 1 (TOP1)
ADC 2-65-1 linker
[150]
ADC-2-65-2
ADC 2-65-2 payload
DNA topoisomerase 1 (TOP1)
ADC 2-65-2 linker
[150]
ADC3-1
ADC 3-1 payload
DNA topoisomerase 1 (TOP1)
ADC 3-1 linker
[150]
ADC3-2
ADC 3-2 payload
DNA topoisomerase 1 (TOP1)
ADC 3-2 linker
[150]
ADC3-3
ADC 3-3 payload
DNA topoisomerase 1 (TOP1)
ADC 3-3 linker
[150]
ADC3-4
ADC 3-4 payload
DNA topoisomerase 1 (TOP1)
ADC 3-4 linker
[150]
ADC3-5
ADC 3-5 payload
DNA topoisomerase 1 (TOP1)
ADC 3-5 linker
[150]
ADC2-A
ADC 2-A payload
DNA topoisomerase 1 (TOP1)
ADC 2-A linker
[150]
ADC2-B
ADC 2-B payload
DNA topoisomerase 1 (TOP1)
ADC 2-B linker
[150]
ADC2-12
ADC 2-12 payload
DNA topoisomerase 1 (TOP1)
ADC 2-12 linker
[150]
HER2-ADC-01 (DAR8)
HER2-ADC-01(DAR8) payload
Undisclosed
HER2-ADC-01(DAR8) linker
[7]
HER2-ADC-02 (DAR8)
HER2-ADC-02(DAR8) payload
Undisclosed
HER2-ADC-02(DAR8) linker
[7]
HER2-ADC-03 (DAR8)
HER2-ADC-03(DAR8) payload
Undisclosed
HER2-ADC-03(DAR8) linker
[7]
HER2-ADC-04 (DAR8)
HER2-ADC-04(DAR8) payload
Undisclosed
HER2-ADC-04(DAR8) linker
[7]
HER2-ADC-05 (DAR8)
HER2-ADC-05(DAR8) payload
Undisclosed
HER2-ADC-05(DAR8) linker
[7]
HER2-ADC-06 (DAR8)
HER2-ADC-06(DAR8) payload
Undisclosed
HER2-ADC-06(DAR8) linker
[7]
HER2-ADC-07 (DAR8)
HER2-ADC-07(DAR8) payload
Undisclosed
HER2-ADC-07(DAR8) linker
[7]
HER2-ADC-08 (DAR8)
HER2-ADC-08(DAR8) payload
Undisclosed
HER2-ADC-08(DAR8) linker
[7]
HER2-ADC-09 (DAR8)
HER2-ADC-09(DAR8) payload
Undisclosed
HER2-ADC-09(DAR8) linker
[7]
HER2-ADC-10 (DAR8)
HER2-ADC-10(DAR8) payload
Undisclosed
HER2-ADC-10(DAR8) linker
[7]
WO2020063676A1 ADC-1
WO2020063676A1_ADC-1 payload
Undisclosed
WO2020063676A1_ADC-1 linker
[82]
WO2020063676A1 ADC-2
WO2020063676A1_ADC-2 payload
Undisclosed
WO2020063676A1_ADC-2 linker
[82]
WO2020063676A1 ADC-3
WO2020063676A1_ADC-3 payload
Undisclosed
WO2020063676A1_ADC-3 linker
[82]
WO2020063676A1 ADC-4
WO2020063676A1_ADC-4 payload
Undisclosed
WO2020063676A1_ADC-4 linker
[82]
WO2020063676A1 ADC-5
WO2020063676A1_ADC-5 payload
Undisclosed
WO2020063676A1_ADC-5 linker
[82]
WO2020063676A1 ADC-6
WO2020063676A1_ADC-6 payload
Undisclosed
WO2020063676A1_ADC-6 linker
[82]
WO2020063676A1 ADC-10
WO2020063676A1_ADC-10 payload
Undisclosed
WO2020063676A1_ADC-10 linker
[82]
WO2020063676A1 ADC-11
WO2020063676A1_ADC-11 payload
Undisclosed
WO2020063676A1_ADC-11 linker
[82]
WO2020063676A1 ADC-12
WO2020063676A1_ADC-12 payload
Undisclosed
WO2020063676A1_ADC-12 linker
[82]
WO2020063676A1 ADC-13
WO2020063676A1_ADC-13 payload
Undisclosed
WO2020063676A1_ADC-13 linker
[82]
WO2020063676A1 ADC-14
WO2020063676A1_ADC-14 payload
Undisclosed
WO2020063676A1_ADC-14 linker
[82]
WO2020063676A1 ADC-15
WO2020063676A1_ADC-15 payload
Undisclosed
WO2020063676A1_ADC-15 linker
[82]
WO2020063676A1 ADC-16
WO2020063676A1_ADC-16 payload
Undisclosed
WO2020063676A1_ADC-16 linker
[82]
WO2020063676A1 ADC-17
WO2020063676A1_ADC-17 payload
Undisclosed
WO2020063676A1_ADC-17 linker
[82]
WO2020063676A1 ADC-18
WO2020063676A1_ADC-18 payload
Undisclosed
WO2020063676A1_ADC-18 linker
[82]
WO2020063676A1 ADC-19
WO2020063676A1_ADC-19 payload
Undisclosed
WO2020063676A1_ADC-19 linker
[82]
WO2020063676A1 ADC-20
WO2020063676A1_ADC-20 payload
Undisclosed
WO2020063676A1_ADC-20 linker
[82]
WO2020063676A1 ADC-21
WO2020063676A1_ADC-21 payload
Undisclosed
WO2020063676A1_ADC-21 linker
[82]
WO2020063676A1 ADC-22
WO2020063676A1_ADC-22 payload
Undisclosed
WO2020063676A1_ADC-22 linker
[82]
WO2020063676A1 ADC-23
WO2020063676A1_ADC-23 payload
Undisclosed
WO2020063676A1_ADC-23 linker
[82]
WO2020063676A1 ADC-24
WO2020063676A1_ADC-24 payload
Undisclosed
WO2020063676A1_ADC-24 linker
[82]
Trastuzumab-Compound (la) DAR 1.6
NeoDegrader P1
Protein cereblon (CRBN)
Trastuzumab-Compound (la) DAR 1.6 linker
[83]
Trastuzumab-Compound (la) DAR 8
NeoDegrader P1
Protein cereblon (CRBN)
Trastuzumab-Compound (la) DAR 8 linker
[83]
Trastuzumab-Compound (Ib) DAR1.5
NeoDegrader P3
Protein cereblon (CRBN)
Trastuzumab-Compound (Ib) DAR1.5 linker
[83]
Trastuzumab-Compound (lc)
NeoDegrader P4
Protein cereblon (CRBN)
Trastuzumab-Compound (lc) linker
[83]
Trastuzumab-Compound (lc) DAR 8
NeoDegrader P4
Protein cereblon (CRBN)
Trastuzumab-Compound (lc) DAR 8 linker
[83]
Trastuzumab-Compound (ld) DAR 1.6
NeoDegrader P1
Protein cereblon (CRBN)
Trastuzumab-Compound (ld) DAR 1.6 linker
[83]
Trastuzumab-Compound (le)
NeoDegrader P1
Protein cereblon (CRBN)
Trastuzumab-Compound (le) linker
[83]
Trastuzumab-Compound (lf)
NeoDegrader P6
Protein cereblon (CRBN)
Trastuzumab-Compound (lf) linker
[83]
Trastuzumab-Compound (lg)
NeoDegrader P2
Protein cereblon (CRBN)
Trastuzumab-Compound (lg) linker
[83]
Trastuzumab-Compound (lh)
NeoDegrader P13
Protein cereblon (CRBN)
Trastuzumab-Compound (lh) linker
[83]
Trastuzumab-Compound (li)
NeoDegrader P1
Protein cereblon (CRBN)
Trastuzumab-Compound (li) linker
[83]
Trastuzumab-Compound (lj)
NeoDegrader P1
Protein cereblon (CRBN)
Trastuzumab-Compound (lj) linker
[83]
Trastuzumab-Compound (lk)
NeoDegrader P14
Protein cereblon (CRBN)
Trastuzumab-Compound (lk) linker
[83]
Trastuzumab-Compound (ll)
NeoDegrader P14
Protein cereblon (CRBN)
Trastuzumab-Compound (ll) linker
[83]
Trastuzumab-Compound (lm)
NeoDegrader P14
Protein cereblon (CRBN)
Trastuzumab-Compound (lm) linker
[83]
WO2017089895A1 ADC1
Monomethyl auristatin E
Microtubule (MT)
WO2017089895A1_ADC1 linker
[151]
WO2017089895A1 ADC2
Monomethyl auristatin F
Microtubule (MT)
WO2017089895A1_ADC2 linker
[151]
WO2017089895A1 ADC3
Monomethyl auristatin E
Microtubule (MT)
WO2017089895A1_ADC3 linker
[151]
WO2017089895A1 ADC4
Monomethyl auristatin F
Microtubule (MT)
WO2017089895A1_ADC4 linker
[151]
WO2017089895A1 ADC5
Monomethyl auristatin E
Microtubule (MT)
WO2017089895A1_ADC5 linker
[151]
WO2017089895A1 ADC6
Monomethyl auristatin F
Microtubule (MT)
WO2017089895A1_ADC6 linker
[151]
WO2017089895A1 ADC7
Monomethyl auristatin E
Microtubule (MT)
WO2017089895A1_ADC7 linker
[151]
WO2017089895A1 ADC8
Monomethyl auristatin F
Microtubule (MT)
WO2017089895A1_ADC8 linker
[151]
WO2017089895A1 ADC9
Monomethyl auristatin E
Microtubule (MT)
WO2017089895A1_ADC9 linker
[151]
WO2017089895A1 ADC10
Monomethyl auristatin E
Microtubule (MT)
WO2017089895A1_ADC10 linker
[151]
WO2017089895A1 ADC11
Monomethyl auristatin E
Microtubule (MT)
WO2017089895A1_ADC11 linker
[151]
WO2017089895A1 ADC12
Monomethyl auristatin E
Microtubule (MT)
WO2017089895A1_ADC12 linker
[151]
WO2017089895A1 ADC13
Monomethyl auristatin E
Microtubule (MT)
WO2017089895A1_ADC13 linker
[151]
WO2017089895A1 ADC14
Monomethyl auristatin F
Microtubule (MT)
WO2017089895A1_ADC14 linker
[151]
WO2017089895A1 ADC15
Monomethyl auristatin E
Microtubule (MT)
WO2017089895A1_ADC15 linker
[151]
WO2017089895A1 ADC16
Monomethyl auristatin F
Microtubule (MT)
WO2017089895A1_ADC16 linker
[151]
WO2017089895A1 ADC17
Monomethyl auristatin E
Microtubule (MT)
WO2017089895A1_ADC17 linker
[151]
WO2017089895A1 ADC18
Monomethyl auristatin F
Microtubule (MT)
WO2017089895A1_ADC18 linker
[151]
WO2017089895A1 ADC19
Monomethyl auristatin E
Microtubule (MT)
WO2017089895A1_ADC19 linker
[151]
WO2017089895A1 ADC20
Monomethyl auristatin F
Microtubule (MT)
WO2017089895A1_ADC20 linker
[151]
WO2017089895A1 ADC86
Monomethyl auristatin F
Microtubule (MT)
WO2017089895A1_ADC86 linker
[151]
WO2017089895A1 ADC87
Monomethyl auristatin E
Microtubule (MT)
WO2017089895A1_ADC87 linker
[151]
WO2017089895A1 ADC23
Monomethyl auristatin F
Microtubule (MT)
WO2017089895A1_ADC23 linker
[151]
WO2017089895A1 ADC24
Monomethyl auristatin E
Microtubule (MT)
WO2017089895A1_ADC24 linker
[151]
WO2017089895A1 ADC25
Monomethyl auristatin E
Microtubule (MT)
WO2017089895A1_ADC25 linker
[151]
WO2017089895A1 ADC26
Monomethyl auristatin E
Microtubule (MT)
WO2017089895A1_ADC26 linker
[151]
WO2017089895A1 ADC27
Monomethyl auristatin E
Microtubule (MT)
WO2017089895A1_ADC27 linker
[151]
WO2017089895A1 ADC28
Monomethyl auristatin E
Microtubule (MT)
WO2017089895A1_ADC28 linker
[151]
WO2017089895A1 ADC29
Monomethyl auristatin E
Microtubule (MT)
WO2017089895A1_ADC29 linker
[151]
WO2017089895A1 ADC30
Monomethyl auristatin E
Microtubule (MT)
WO2017089895A1_ADC30 linker
[151]
WO2017089895A1 ADC31
Monomethyl auristatin E
Microtubule (MT)
WO2017089895A1_ADC31 linker
[151]
WO2017089895A1 ADC32
Monomethyl auristatin E
Microtubule (MT)
WO2017089895A1_ADC32 linker
[151]
WO2017089895A1 ADC33
Monomethyl auristatin E
Microtubule (MT)
WO2017089895A1_ADC33 linker
[151]
WO2017089895A1 ADC34
Monomethyl auristatin F
Microtubule (MT)
WO2017089895A1_ADC34 linker
[151]
WO2017089895A1 ADC35
Monomethyl auristatin E
Microtubule (MT)
WO2017089895A1_ADC35 linker
[151]
WO2017089895A1 ADC36
Monomethyl auristatin E
Microtubule (MT)
WO2017089895A1_ADC36 linker
[151]
WO2017089895A1 ADC37
Monomethyl auristatin E
Microtubule (MT)
WO2017089895A1_ADC37 linker
[151]
WO2017089895A1 ADC38
Monomethyl auristatin F
Microtubule (MT)
WO2017089895A1_ADC38 linker
[151]
WO2017089895A1 ADC39
Monomethyl auristatin E
Microtubule (MT)
WO2017089895A1_ADC39 linker
[151]
WO2017089895A1 ADC40
Monomethyl auristatin F
Microtubule (MT)
WO2017089895A1_ADC40 linker
[151]
WO2017089895A1 ADC41
Monomethyl auristatin E
Microtubule (MT)
WO2017089895A1_ADC41 linker
[151]
WO2017089895A1 ADC42
Monomethyl auristatin F
Microtubule (MT)
WO2017089895A1_ADC42 linker
[151]
WO2017089895A1 ADC43
Monomethyl auristatin E
Microtubule (MT)
WO2017089895A1_ADC43 linker
[151]
WO2017089895A1 ADC44
Monomethyl auristatin F
Microtubule (MT)
WO2017089895A1_ADC44 linker
[151]
WO2017089895A1 ADC45
Monomethyl auristatin E
Microtubule (MT)
WO2017089895A1_ADC45 linker
[151]
WO2017089895A1 ADC46
Monomethyl auristatin F
Microtubule (MT)
WO2017089895A1_ADC46 linker
[151]
WO2017089895A1 ADC47
Monomethyl auristatin E
Microtubule (MT)
WO2017089895A1_ADC47 linker
[151]
WO2017089895A1 ADC48
Monomethyl auristatin F
Microtubule (MT)
WO2017089895A1_ADC48 linker
[151]
WO2017089895A1 ADC49
Monomethyl auristatin E
Microtubule (MT)
WO2017089895A1_ADC49 linker
[151]
WO2017089895A1 ADC50
Monomethyl auristatin F
Microtubule (MT)
WO2017089895A1_ADC50 linker
[151]
WO2017089895A1 ADC51
Monomethyl auristatin E
Microtubule (MT)
WO2017089895A1_ADC51 linker
[151]
WO2017089895A1 ADC52
Monomethyl auristatin E
Microtubule (MT)
WO2017089895A1_ADC52 linker
[151]
WO2017089895A1 ADC53
Monomethyl auristatin F
Microtubule (MT)
WO2017089895A1_ADC53 linker
[151]
WO2017089895A1 ADC54
Monomethyl auristatin F
Microtubule (MT)
WO2017089895A1_ADC54 linker
[151]
WO2017089895A1 ADC55
Monomethyl auristatin F
Microtubule (MT)
WO2017089895A1_ADC55 linker
[151]
WO2017089895A1 ADC76
Monomethyl auristatin F
Microtubule (MT)
WO2017089895A1_ADC76 linker
[151]
WO2017089895A1 ADC88
Monomethyl auristatin F
Microtubule (MT)
WO2017089895A1_ADC88 linker
[151]
WO2017089895A1 ADC89
Monomethyl auristatin F
Microtubule (MT)
WO2017089895A1_ADC89 linker
[151]
WO2017089895A1 ADC90
Monomethyl auristatin F
Microtubule (MT)
WO2017089895A1_ADC90 linker
[151]
WO2017089895A1 ADC91
Monomethyl auristatin E
Microtubule (MT)
WO2017089895A1_ADC91 linker
[151]
WO2017089895A1 ADC60
Monomethyl auristatin F
Microtubule (MT)
WO2017089895A1_ADC60 linker
[151]
WO2017089895A1 ADC61
Monomethyl auristatin E
Microtubule (MT)
WO2017089895A1_ADC61 linker
[151]
WO2017089895A1 ADC62
Monomethyl auristatin F
Microtubule (MT)
WO2017089895A1_ADC62 linker
[151]
WO2017089895A1 ADC63
Monomethyl auristatin E
Microtubule (MT)
WO2017089895A1_ADC63 linker
[151]
WO2017089895A1 ADC77
Monomethyl auristatin F
Microtubule (MT)
WO2017089895A1_ADC77 linker
[151]
WO2017089895A1 ADC21
Alpha-amanitin
DNA-directed RNA polymerase II subunit RPB2 (POLR2B); DNA-directed RNA polymerase III subunit RPC7 (POLR3G)
WO2017089895A1_ADC21 linker
[151]
WO2017089895A1 ADC22
Alpha-amanitin
DNA-directed RNA polymerase II subunit RPB2 (POLR2B); DNA-directed RNA polymerase III subunit RPC7 (POLR3G)
WO2017089895A1_ADC22 linker
[151]
WO2017089895A1 ADC56
Alpha-amanitin
DNA-directed RNA polymerase II subunit RPB2 (POLR2B); DNA-directed RNA polymerase III subunit RPC7 (POLR3G)
WO2017089895A1_ADC56 linker
[151]
WO2017089895A1 ADC57
Alpha-amanitin
DNA-directed RNA polymerase II subunit RPB2 (POLR2B); DNA-directed RNA polymerase III subunit RPC7 (POLR3G)
WO2017089895A1_ADC57 linker
[151]
WO2017089895A1 ADC58
Alpha-amanitin+Monomethyl auristatin F
Undisclosed
WO2017089895A1_ADC58 linker
[151]
WO2017089895A1 ADC59
Alpha-amanitin+Monomethyl auristatin F
Undisclosed
WO2017089895A1_ADC59 linker
[151]
HER2-B Antibody-Compound (X)
HER2-B Antibody-Compound (X) payload
Undisclosed
HER2-B Antibody-Compound (X) linker
[53]
HER2-B Antibody-Compound (XI)
HER2-B Antibody-Compound (XI) payload
Undisclosed
HER2-B Antibody-Compound (XI) linker
[53]
HER2-B Antibody-Compound (XIV)
HER2-B Antibody-Compound (XIV) payload
Undisclosed
HER2-B Antibody-Compound (XIV) linker
[53]
HER2-B Antibody-Compound (XVIII)
HER2-B Antibody-Compound (XVIII) payload
Undisclosed
HER2-B Antibody-Compound (XVIII) linker
[53]
HER2-B Antibody-Compound (Ie)
HER2-B Antibody-Compound (Ie) payload
Undisclosed
HER2-B Antibody-Compound (Ie) linker
[53]
HER2-B Antibody-Compound (XIX)
HER2-B Antibody-Compound (XIX) payload
Undisclosed
HER2-B Antibody-Compound (XIX) linker
[53]
HER2-B Antibody-Compound (Ii)
HER2-B Antibody-Compound (Ii) payload
Undisclosed
HER2-B Antibody-Compound (Ii) linker
[53]
HER2-B Antibody-Compound (XLI)
HER2-B Antibody-Compound (XLI) payload
Undisclosed
HER2-B Antibody-Compound (XLI) linker
[53]
HER2-B Antibody-Compound (XVI)
HER2-B Antibody-Compound (XIX) payload
Undisclosed
HER2-B Antibody-Compound (XIX) linker
[53]
HER2-B Antibody-Compound (XL)
HER2-B Antibody-Compound (XL) payload
Undisclosed
HER2-B Antibody-Compound (XL) linker
[53]
HER2-B Antibody-Compound (XLIII)
HER2-B Antibody-Compound (XLIII) payload
Undisclosed
HER2-B Antibody-Compound (XLIII) linker
[53]
HER2-B Antibody-Compound (XLII)
HER2-B Antibody-Compound (XLII) payload
Undisclosed
HER2-B Antibody-Compound (XLII) linker
[53]
Trastuzumab-Compound (XV)
Trastuzumab-Compound (XV) payload
Undisclosed
Trastuzumab-Compound (XV) linker
[53]
WO2013055987A1 Tmab-101
SG2000
Human Deoxyribonucleic acid (hDNA)
WO2013055987A1_Tmab-101 linker
[152]
WO2013055987A1 Tmab-102
SG2000
Human Deoxyribonucleic acid (hDNA)
WO2013055987A1_Tmab-102 linker
[152]
WO2013055987A1 Tmab-104
SG2000
Human Deoxyribonucleic acid (hDNA)
WO2013055987A1_Tmab-104 linker
[152]
WO2013055987A1 Tmab-110
SG2000
Human Deoxyribonucleic acid (hDNA)
WO2013055987A1_Tmab-110 linker
[152]
WO2014159981A2 ADC-110
WO2014159981A2_ADC-110 payload
Undisclosed
WO2014159981A2_ADC-110 linker
[97]
WO2014159981A2 ADC-120
WO2014159981A2_ADC-120 payload
Undisclosed
WO2014159981A2_ADC-120 linker
[97]
ADC-II-1
ADC-II-1 payload
Undisclosed
ADC-II-1 linker
[153]
ADC-II-5
ADC-II-5 payload
Undisclosed
ADC-II-5 linker
[153]
ADC-II-9
ADC-II-9 payload
Undisclosed
ADC-II-9 linker
[153]
ADC-II-13
ADC-II-13 payload
Undisclosed
ADC-II-13 linker
[153]
ADC-I-1
ADC-I-1 payload
Undisclosed
ADC-I-1 linker
[153]
ADC-III-1
ADC-III-1 payload
Undisclosed
ADC-III-1 linker
[153]
ADC-III-9
ADC-III-9 payload
Undisclosed
ADC-III-9 linker
[153]
WO2022078260A1 ADC-1
Ln-D9
DNA topoisomerase 1 (TOP1)
WO2022078260A1_ADC-1 linker
[154]
WO2022078260A1 ADC-2
Ln-D1
DNA topoisomerase 1 (TOP1)
WO2022078260A1_ADC-2 linker
[154]
WO2022078260A1 ADC-3
Ln-D2
DNA topoisomerase 1 (TOP1)
WO2022078260A1_ADC-3 linker
[154]
WO2022078260A1 ADC-4
Ln-D4
DNA topoisomerase 1 (TOP1)
WO2022078260A1_ADC-4 linker
[154]
WO2022078260A1 ADC-5
Ln-D5
DNA topoisomerase 1 (TOP1)
WO2022078260A1_ADC-5 linker
[154]
WO2022078260A1 ADC-6
Ln-D6
DNA topoisomerase 1 (TOP1)
WO2022078260A1_ADC-6 linker
[154]
WO2022078260A1 ADC-7
Ln-D7
DNA topoisomerase 1 (TOP1)
WO2022078260A1_ADC-7 linker
[154]
WO2022078260A1 ADC-8
Ln-D8
DNA topoisomerase 1 (TOP1)
WO2022078260A1_ADC-8 linker
[154]
WO2021249228A1 ADC-1
WO2021249228A1_ADC-1 payload
Undisclosed
WO2021249228A1_ADC-1 linker
[155]
WO2021249228A1 ADC-2
WO2021249228A1_ADC-2 payload
Undisclosed
WO2021249228A1_ADC-2 linker
[155]
WO2021249228A1 ADC-3
WO2021249228A1_ADC-3 payload
Undisclosed
WO2021249228A1_ADC-3 linker
[155]
WO2021249228A1 ADC-4
WO2021249228A1_ADC-4 payload
Undisclosed
WO2021249228A1_ADC-4 linker
[155]
WO2021249228A1 ADC-5
WO2021249228A1_ADC-5 payload
Undisclosed
WO2021249228A1_ADC-5 linker
[155]
WO2021249228A1 ADC-6
WO2021249228A1_ADC-6 payload
Undisclosed
WO2021249228A1_ADC-6 linker
[155]
WO2021249228A1 ADC-7
WO2021249228A1_ADC-7 payload
Undisclosed
WO2021249228A1_ADC-7 linker
[155]
WO2021249228A1 ADC-8
WO2021249228A1_ADC-8 payload
Undisclosed
WO2021249228A1_ADC-8 linker
[155]
WO2021249228A1 ADC-9
WO2021249228A1_ADC-9 payload
Undisclosed
WO2021249228A1_ADC-9 linker
[155]
WO2021249228A1 ADC-10
WO2021249228A1_ADC-10 payload
Undisclosed
WO2021249228A1_ADC-10 linker
[155]
WO2021249228A1 ADC-11
WO2021249228A1_ADC-11 payload
Undisclosed
WO2021249228A1_ADC-11 linker
[155]
WO2021249228A1 ADC-12
WO2021249228A1_ADC-12 payload
Undisclosed
WO2021249228A1_ADC-12 linker
[155]
WO2021249228A1 ADC-13
WO2021249228A1_ADC-13 payload
Undisclosed
WO2021249228A1_ADC-13 linker
[155]
WO2021249228A1 ADC-14
WO2021249228A1_ADC-14 payload
Undisclosed
WO2021249228A1_ADC-14 linker
[155]
WO2021249228A1 ADC-15
WO2021249228A1_ADC-15 payload
Undisclosed
WO2021249228A1_ADC-15 linker
[155]
WO2021249228A1 ADC-16
WO2021249228A1_ADC-16 payload
Undisclosed
WO2021249228A1_ADC-16 linker
[155]
WO2021249228A1 ADC-17
WO2021249228A1_ADC-17 payload
Undisclosed
WO2021249228A1_ADC-17 linker
[155]
WO2021249228A1 ADC-18
WO2021249228A1_ADC-18 payload
Undisclosed
WO2021249228A1_ADC-18 linker
[155]
WO2021249228A1 ADC-19
WO2021249228A1_ADC-19 payload
Undisclosed
WO2021249228A1_ADC-19 linker
[155]
WO2021249228A1 ADC-20
WO2021249228A1_ADC-20 payload
Undisclosed
WO2021249228A1_ADC-20 linker
[155]
WO2021249228A1 ADC-21
WO2021249228A1_ADC-21 payload
Undisclosed
WO2021249228A1_ADC-21 linker
[155]
WO2021249228A1 ADC-22
WO2021249228A1_ADC-22 payload
Undisclosed
WO2021249228A1_ADC-22 linker
[155]
WO2021249228A1 ADC-23
WO2021249228A1_ADC-23 payload
Undisclosed
WO2021249228A1_ADC-23 linker
[155]
WO2021249228A1 ADC-24
WO2021249228A1_ADC-24 payload
Undisclosed
WO2021249228A1_ADC-24 linker
[155]
WO2021249228A1 ADC-25
WO2021249228A1_ADC-25 payload
Undisclosed
WO2021249228A1_ADC-25 linker
[155]
WO2021249228A1 ADC-26
WO2021249228A1_ADC-26 payload
Undisclosed
WO2021249228A1_ADC-26 linker
[155]
WO2021249228A1 ADC-27
WO2021249228A1_ADC-27 payload
Undisclosed
WO2021249228A1_ADC-27 linker
[155]
WO2021249228A1 ADC-28
WO2021249228A1_ADC-28 payload
Undisclosed
WO2021249228A1_ADC-28 linker
[155]
WO2021249228A1 ADC-29
WO2021249228A1_ADC-29 payload
Undisclosed
WO2021249228A1_ADC-29 linker
[155]
WO2021249228A1 ADC-30
WO2021249228A1_ADC-30 payload
Undisclosed
WO2021249228A1_ADC-30 linker
[155]
WO2021249228A1 ADC-31
WO2021249228A1_ADC-31 payload
Undisclosed
WO2021249228A1_ADC-31 linker
[155]
WO2021249228A1 ADC-32
WO2021249228A1_ADC-32 payload
Undisclosed
WO2021249228A1_ADC-32 linker
[155]
WO2021249228A1 ADC-33
WO2021249228A1_ADC-33 payload
Undisclosed
WO2021249228A1_ADC-33 linker
[155]
WO2021249228A1 ADC-34
WO2021249228A1_ADC-34 payload
Undisclosed
WO2021249228A1_ADC-34 linker
[155]
WO2021249228A1 ADC-35
WO2021249228A1_ADC-35 payload
Undisclosed
WO2021249228A1_ADC-35 linker
[155]
WO2021249228A1 ADC-36
WO2021249228A1_ADC-36 payload
Undisclosed
WO2021249228A1_ADC-36 linker
[155]
WO2021249228A1 ADC-37
WO2021249228A1_ADC-37 payload
Undisclosed
WO2021249228A1_ADC-37 linker
[155]
WO2021249228A1 ADC-38
WO2021249228A1_ADC-38 payload
Undisclosed
WO2021249228A1_ADC-38 linker
[155]
WO2021249228A1 ADC-39
WO2021249228A1_ADC-39 payload
Undisclosed
WO2021249228A1_ADC-39 linker
[155]
WO2021249228A1 ADC-40
WO2021249228A1_ADC-40 payload
Undisclosed
WO2021249228A1_ADC-40 linker
[155]
WO2021249228A1 ADC-41
WO2021249228A1_ADC-41 payload
Undisclosed
WO2021249228A1_ADC-41 linker
[155]
WO2021249228A1 ADC-42
WO2021249228A1_ADC-42 payload
Undisclosed
WO2021249228A1_ADC-42 linker
[155]
WO2021249228A1 ADC-43
WO2021249228A1_ADC-43 payload
Undisclosed
WO2021249228A1_ADC-43 linker
[155]
WO2021249228A1 ADC-44
WO2021249228A1_ADC-44 payload
Undisclosed
WO2021249228A1_ADC-44 linker
[155]
WO2021249228A1 ADC-45
WO2021249228A1_ADC-45 payload
Undisclosed
WO2021249228A1_ADC-45 linker
[155]
WO2021249228A1 ADC-46
WO2021249228A1_ADC-46 payload
Undisclosed
WO2021249228A1_ADC-46 linker
[155]
WO2021249228A1 ADC-47
WO2021249228A1_ADC-47 payload
Undisclosed
WO2021249228A1_ADC-47 linker
[155]
WO2021249228A1 ADC-48
WO2021249228A1_ADC-48 payload
Undisclosed
WO2021249228A1_ADC-48 linker
[155]
WO2021249228A1 ADC-49
WO2021249228A1_ADC-49 payload
Undisclosed
WO2021249228A1_ADC-49 linker
[155]
WO2021249228A1 ADC-50
WO2021249228A1_ADC-50 payload
Undisclosed
WO2021249228A1_ADC-50 linker
[155]
WO2021249228A1 ADC-51
WO2021249228A1_ADC-51 payload
Undisclosed
WO2021249228A1_ADC-51 linker
[155]
WO2021249228A1 ADC-52
WO2021249228A1_ADC-52 payload
Undisclosed
WO2021249228A1_ADC-52 linker
[155]
WO2021249228A1 ADC-53
WO2021249228A1_ADC-53 payload
Undisclosed
WO2021249228A1_ADC-53 linker
[155]
WO2021249228A1 ADC-54
WO2021249228A1_ADC-54 payload
Undisclosed
WO2021249228A1_ADC-54 linker
[155]
WO2021249228A1 ADC-55
WO2021249228A1_ADC-55 payload
Undisclosed
WO2021249228A1_ADC-55 linker
[155]
WO2021249228A1 ADC-56
WO2021249228A1_ADC-56 payload
Undisclosed
WO2021249228A1_ADC-56 linker
[155]
WO2021249228A1 ADC-57
WO2021249228A1_ADC-57 payload
Undisclosed
WO2021249228A1_ADC-57 linker
[155]
WO2021249228A1 ADC-58
WO2021249228A1_ADC-58 payload
Undisclosed
WO2021249228A1_ADC-58 linker
[155]
WO2021249228A1 ADC-59
WO2021249228A1_ADC-59 payload
Undisclosed
WO2021249228A1_ADC-59 linker
[155]
WO2021249228A1 ADC-60
WO2021249228A1_ADC-60 payload
Undisclosed
WO2021249228A1_ADC-60 linker
[155]
WO2021249228A1 ADC-61
WO2021249228A1_ADC-61 payload
Undisclosed
WO2021249228A1_ADC-61 linker
[155]
WO2022228495A1 ADC-67
WO2022228495A1 ADC-67 payload
Undisclosed
WO2022228495A1 ADC-67 linker
[50]
WO2022228495A1 ADC-68
WO2022228495A1 ADC-68 payload
Undisclosed
WO2022228495A1 ADC-68 linker
[50]
WO2022228495A1 ADC-69
WO2022228495A1 ADC-69 payload
Undisclosed
WO2022228495A1 ADC-69 linker
[50]
WO2022228495A1 ADC-70
WO2022228495A1 ADC-70 payload
Undisclosed
WO2022228495A1 ADC-70 linker
[50]
WO2022228495A1 ADC-71
WO2022228495A1 ADC-71 payload
Undisclosed
WO2022228495A1 ADC-71 linker
[50]
WO2022228495A1 ADC-74
WO2022228495A1 ADC-74 payload
Undisclosed
WO2022228495A1 ADC-74 linker
[50]
WO2022228495A1 ADC-75
WO2022228495A1 ADC-75 payload
Undisclosed
WO2022228495A1 ADC-75 linker
[50]
HER2-MMAU ADC
Glucuronyl-monomethyl-auristatin E (MMAU)
Microtubule (MT)
Mc-Val-Cit-PABC
[156]
PF-06888667
SW-163D
Human Deoxyribonucleic acid (hDNA)
AcLys-Val-Cit-PABC-DMAE
[157]
TTZ-1-MMAE
Monomethyl auristatin E
Microtubule (MT)
DSPh-Val-Ala-PABC
[158]
TTZ-2-MMAE
Monomethyl auristatin E
Microtubule (MT)
DSPh-Val-Cit-PABC
[158]
TTZ-3-MMAE
Monomethyl auristatin E
Microtubule (MT)
DSPh-PEG12-Val-Ala-PABC
[158]
TTZ-4-MMAE
Monomethyl auristatin E
Microtubule (MT)
DSPh-PEG12-Val-Cit-PABC
[158]
Trastuzumab-DVP-linker-MMAE 1
Monomethyl auristatin E
Microtubule (MT)
DVP-based linker 1f
[159]
Trastuzumab-Val-Cit linker-MMAE 2
Monomethyl auristatin E
Microtubule (MT)
Val-Cit linker 2e
[159]
Trastuzumab-DVP-linker-MMAE 3
Monomethyl auristatin E
Microtubule (MT)
DVP-based linker 3
[159]
Trastuzumab-DVP-linker-MMAE 4
Monomethyl auristatin E
Microtubule (MT)
DVP-based linker 4
[159]
Trastuzumab-Me-PRX conjugate
Methylated-beta-Cyclodextrin/Pluronic P103-based polyrotaxane (Me-PRX)
Undisclosed
Phenyl maleimide PEG2
[160]
HER2-acetal-ADC 11
Monomethyl auristatin F
Microtubule (MT)
Clravable-acetal based linker 11
[161]
HER2-acetal-ADC 12
Monomethyl auristatin F
Microtubule (MT)
Clravable-TAMRA-acetal based linker 12
[161]
HER2-azide-alkyne MMAE conjugate
Monomethyl auristatin E
Microtubule (MT)
Azide-alkyne based linker 10a
[162]
HER2-cyclopropene-tetrazine MMAE conjugate
Monomethyl auristatin E
Microtubule (MT)
Cyclopropene-tetrazine based linker 10b
[162]
HER2-norbornene-tetrazine MMAE conjugate
Monomethyl auristatin E
Microtubule (MT)
Norbornene-tetrazine based linker 10c
[162]
T-FcBP-DM1
Mertansine DM1
Microtubule (MT)
N-terminal norbornene group pFcBP linker
[163]
T-D8-1508
AZ-1508
Microtubule (MT)
Cysteine D8
[164]
T-D6-1508
AZ-1508
Microtubule (MT)
Cysteine D6
[164]
T-D4-1508
AZ-1508
Microtubule (MT)
Cysteine D4
[164]
T-D2-1508
AZ-1508
Microtubule (MT)
Cysteine D2
[164]
HER2 ADC-18
Monomethyl auristatin E
Microtubule (MT)
Vinylsulfonamide based linker 15
[165]
HER2 ADC-19
Monomethyl auristatin E
Microtubule (MT)
Vinylsulfonamide based linker 16
[165]
HER2 ADC-20
Monomethyl auristatin E
Microtubule (MT)
Vinylsulfonamide based linker 17
[165]
T-DM1-IR700
Mertansine DM1 plus IRDye700DX
Microtubule (MT)
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
[166]
HER2-gsADC-46
Monomethyl auristatin E
Microtubule (MT)
ThioPz linker 6a
[36]
HER2-gsADC-47
Monomethyl auristatin E
Microtubule (MT)
Hydroxylamine derivative 6c
[36]
HER2-gsADC-48
Monomethyl auristatin E
Microtubule (MT)
2-Aminobenzamide oxime
[36]
HER2-gsADC-49
Monomethyl auristatin E
Microtubule (MT)
Azadibenzocylooctyne-amine derivative 6d
[36]
HER2-gsADC-50
Monomethyl auristatin E
Microtubule (MT)
2-Aminobenzamidoxime without core-fucosylation
[36]
T-DM1-2.6
Mertansine DM1
Microtubule (MT)
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
[36]
Trastuzumab-amanitin 1
Beta-amanitin
DNA-directed RNA polymerase II subunit RPB2 (POLR2B); DNA-directed RNA polymerase III subunit RPC7 (POLR3G)
Trastuzumab-Amanitin1 linker
[167]
Trastuzumab-alpha-amanitin conjugate 3
Alpha-amanitin
DNA-directed RNA polymerase II subunit RPB2 (POLR2B); DNA-directed RNA polymerase III subunit RPC7 (POLR3G)
Trastuzumab-alpha-amanitin conjugate 3 linker
[167]
Trastuzumab-alpha-amanitin conjugate 4
Alpha-amanitin
DNA-directed RNA polymerase II subunit RPB2 (POLR2B); DNA-directed RNA polymerase III subunit RPC7 (POLR3G)
Trastuzumab-alpha-amanitin conjugate 4 linker
[167]
Trastuzumab-alpha-amanitin conjugate 7
Alpha-amanitin
DNA-directed RNA polymerase II subunit RPB2 (POLR2B); DNA-directed RNA polymerase III subunit RPC7 (POLR3G)
Trastuzumab-alpha-amanitin conjugate 7 linker
[167]
Trastuzumab-alpha-amanitin conjugate 10
Alpha-amanitin
DNA-directed RNA polymerase II subunit RPB2 (POLR2B); DNA-directed RNA polymerase III subunit RPC7 (POLR3G)
Trastuzumab-alpha-amanitin conjugate 10 linker
[167]
Trastuzumab-alpha-amanitin conjugate 11
Alpha-amanitin
DNA-directed RNA polymerase II subunit RPB2 (POLR2B); DNA-directed RNA polymerase III subunit RPC7 (POLR3G)
Trastuzumab-alpha-amanitin conjugate 11 linker
[167]
Trastuzumab-alpha-amanitin conjugate 14
Alpha-amanitin
DNA-directed RNA polymerase II subunit RPB2 (POLR2B); DNA-directed RNA polymerase III subunit RPC7 (POLR3G)
Trastuzumab-alpha-amanitin conjugate 14 linker
[167]
Trastuzumab-alpha-amanitin conjugate 15
Alpha-amanitin
DNA-directed RNA polymerase II subunit RPB2 (POLR2B); DNA-directed RNA polymerase III subunit RPC7 (POLR3G)
Trastuzumab-alpha-amanitin conjugate 15 linker
[167]
Trastuzumab-amanitin 3
Beta-amanitin
DNA-directed RNA polymerase II subunit RPB2 (POLR2B); DNA-directed RNA polymerase III subunit RPC7 (POLR3G)
Trastuzumab-Amanitin3 linker
[167]
Trastuzumab-amanitin 4
Beta-amanitin
DNA-directed RNA polymerase II subunit RPB2 (POLR2B); DNA-directed RNA polymerase III subunit RPC7 (POLR3G)
Trastuzumab-Amanitin4 linker
[167]
Her-30.0643
HDP 30.0643
DNA-directed RNA polymerase II subunit RPB2 (POLR2B); DNA-directed RNA polymerase III subunit RPC7 (POLR3G)
Her-30.0643 linker
[168]
Her-30.1033
HDP 30.1033
Undisclosed
Her-30.1033 linker
[168]
Her-30.1036
HDP 30.1036
Undisclosed
Her-30.1036 linker
[168]
Her-30.1165
HDP 30.1165
Undisclosed
Her-30.1165 linker
[168]
Her-30.0132
HDP 30.0132
Undisclosed
Her-30.0132 linker
[168]
Her-30.0134
HDP 30.0134
Undisclosed
Her-30.0134 linker
[168]
Her-30.0741
HDP 30.0741
Undisclosed
Her-30.0741 linker
[168]
Her-30.0743
HDP 30.0743
Undisclosed
Her-30.0743 linker
[168]
Trastuzumab-E-13
Trastuzumab-E-13 payload
Undisclosed
Trastuzumab-E-13 linker
[169]
Trastuzumab-G-13
Trastuzumab-G-13 payload
Undisclosed
Trastuzumab-G-13 linker
[169]
Trastuzumab-E-11
Trastuzumab-E-11 payload
Undisclosed
Trastuzumab-E-11 linker
[169]
Trastuzumab-E-12
Trastuzumab-E-12 payload
Undisclosed
Trastuzumab-E-12 payload
[169]
Trastuzumab-G-12
Trastuzumab-G-12 payload
Undisclosed
Trastuzumab-G-12E-11
[169]
Trastuzumab-F-13
Trastuzumab-F-13 payload
Undisclosed
Trastuzumab-F-13E-12
[169]
Trastuzumab-E-15
Trastuzumab-E-15 payload
Undisclosed
Trastuzumab-E-15G-12
[169]
Trastuzumab-G-15
Trastuzumab-G-15 payload
Undisclosed
Trastuzumab-G-15F-13
[169]
Trastuzumab-F-61
Trastuzumab-F-61 payload
Undisclosed
Trastuzumab-F-61E-15
[169]
Trastuzumab-F-62
Trastuzumab-F-62 payload
Undisclosed
Trastuzumab-F-62G-15
[169]
Trastuzumab-F-63
Trastuzumab-F-63 payload
Undisclosed
Trastuzumab-F-63F-61
[169]
WO2017089890A1 ADC1
Monomethyl auristatin E
Microtubule (MT)
WO2017089890A1_ADC1 linker
[170]
WO2017089890A1 ADC2
Monomethyl auristatin F
Microtubule (MT)
WO2017089890A1_ADC2 linker
[170]
WO2017089890A1 ADC3
Monomethyl auristatin E
Microtubule (MT)
WO2017089890A1_ADC3 linker
[170]
WO2017089890A1 ADC4
Monomethyl auristatin F
Microtubule (MT)
WO2017089890A1_ADC4 linker
[170]
WO2017089890A1 ADC5
Monomethyl auristatin E
Microtubule (MT)
WO2017089890A1_ADC5 linker
[170]
WO2017089890A1 ADC6
Monomethyl auristatin F
Microtubule (MT)
WO2017089890A1_ADC6 linker
[170]
WO2017089890A1 ADC7
Monomethyl auristatin E
Microtubule (MT)
WO2017089890A1_ADC7 linker
[170]
WO2017089890A1 ADC8
Monomethyl auristatin F
Microtubule (MT)
WO2017089890A1_ADC8 linker
[170]
WO2017089890A1 ADC9
Monomethyl auristatin E
Microtubule (MT)
WO2017089890A1_ADC9 linker
[170]
WO2017089890A1 ADC10
Monomethyl auristatin E
Microtubule (MT)
WO2017089890A1_ADC10 linker
[170]
WO2017089890A1 ADC11
Monomethyl auristatin E
Microtubule (MT)
WO2017089890A1_ADC11 linker
[170]
WO2017089890A1 ADC12
Monomethyl auristatin E
Microtubule (MT)
WO2017089890A1_ADC12 linker
[170]
WO2017089890A1 ADC13
Monomethyl auristatin E
Microtubule (MT)
WO2017089890A1_ADC13 linker
[170]
WO2017089890A1 ADC14
Monomethyl auristatin F
Microtubule (MT)
WO2017089890A1_ADC14 linker
[170]
WO2017089890A1 ADC15
Monomethyl auristatin E
Microtubule (MT)
WO2017089890A1_ADC15 linker
[170]
WO2017089890A1 ADC16
Monomethyl auristatin F
Microtubule (MT)
WO2017089890A1_ADC16 linker
[170]
WO2017089890A1 ADC17
Monomethyl auristatin E
Microtubule (MT)
WO2017089890A1_ADC17 linker
[170]
WO2017089890A1 ADC18
Monomethyl auristatin F
Microtubule (MT)
WO2017089890A1_ADC18 linker
[170]
WO2017089890A1 ADC19
Monomethyl auristatin E
Microtubule (MT)
WO2017089890A1_ADC19 linker
[170]
WO2017089890A1 ADC20
Monomethyl auristatin F
Microtubule (MT)
WO2017089890A1_ADC20 linker
[170]
WO2017089890A1 ADC86
Monomethyl auristatin F
Microtubule (MT)
WO2017089890A1_ADC86 linker
[170]
WO2017089890A1 ADC87
Monomethyl auristatin E
Microtubule (MT)
WO2017089890A1_ADC87 linker
[170]
WO2017089890A1 ADC23
Monomethyl auristatin F
Microtubule (MT)
WO2017089890A1_ADC23 linker
[170]
WO2017089890A1 ADC24
Monomethyl auristatin E
Microtubule (MT)
WO2017089890A1_ADC24 linker
[170]
WO2017089890A1 ADC25
Monomethyl auristatin E
Microtubule (MT)
WO2017089890A1_ADC25 linker
[170]
WO2017089890A1 ADC26
Monomethyl auristatin E
Microtubule (MT)
WO2017089890A1_ADC26 linker
[170]
WO2017089890A1 ADC27
Monomethyl auristatin E
Microtubule (MT)
WO2017089890A1_ADC27 linker
[170]
WO2017089890A1 ADC28
Monomethyl auristatin E
Microtubule (MT)
WO2017089890A1_ADC28 linker
[170]
WO2017089890A1 ADC29
Monomethyl auristatin E
Microtubule (MT)
WO2017089890A1_ADC29 linker
[170]
WO2017089890A1 ADC30
Monomethyl auristatin E
Microtubule (MT)
WO2017089890A1_ADC30 linker
[170]
WO2017089890A1 ADC31
Monomethyl auristatin E
Microtubule (MT)
WO2017089890A1_ADC31 linker
[170]
WO2017089890A1 ADC32
Monomethyl auristatin E
Microtubule (MT)
WO2017089890A1_ADC32 linker
[170]
WO2017089890A1 ADC33
Monomethyl auristatin E
Microtubule (MT)
WO2017089890A1_ADC33 linker
[170]
WO2017089890A1 ADC34
Monomethyl auristatin F
Microtubule (MT)
WO2017089890A1_ADC34 linker
[170]
WO2017089890A1 ADC35
Monomethyl auristatin E
Microtubule (MT)
WO2017089890A1_ADC35 linker
[170]
WO2017089890A1 ADC36
Monomethyl auristatin E
Microtubule (MT)
WO2017089890A1_ADC36 linker
[170]
WO2017089890A1 ADC37
Monomethyl auristatin E
Microtubule (MT)
WO2017089890A1_ADC37 linker
[170]
WO2017089890A1 ADC38
Monomethyl auristatin F
Microtubule (MT)
WO2017089890A1_ADC38 linker
[170]
WO2017089890A1 ADC39
Monomethyl auristatin E
Microtubule (MT)
WO2017089890A1_ADC39 linker
[170]
WO2017089890A1 ADC40
Monomethyl auristatin F
Microtubule (MT)
WO2017089890A1_ADC40 linker
[170]
WO2017089890A1 ADC41
Monomethyl auristatin E
Microtubule (MT)
WO2017089890A1_ADC41 linker
[170]
WO2017089890A1 ADC42
Monomethyl auristatin F
Microtubule (MT)
WO2017089890A1_ADC42 linker
[170]
WO2017089890A1 ADC43
Monomethyl auristatin E
Microtubule (MT)
WO2017089890A1_ADC43 linker
[170]
WO2017089890A1 ADC44
Monomethyl auristatin F
Microtubule (MT)
WO2017089890A1_ADC44 linker
[170]
WO2017089890A1 ADC45
Monomethyl auristatin E
Microtubule (MT)
WO2017089890A1_ADC45 linker
[170]
WO2017089890A1 ADC46
Monomethyl auristatin F
Microtubule (MT)
WO2017089890A1_ADC46 linker
[170]
WO2017089890A1 ADC47
Monomethyl auristatin E
Microtubule (MT)
WO2017089890A1_ADC47 linker
[170]
WO2017089890A1 ADC48
Monomethyl auristatin F
Microtubule (MT)
WO2017089890A1_ADC48 linker
[170]
WO2017089890A1 ADC49
Monomethyl auristatin E
Microtubule (MT)
WO2017089890A1_ADC49 linker
[170]
WO2017089890A1 ADC50
Monomethyl auristatin F
Microtubule (MT)
WO2017089890A1_ADC50 linker
[170]
WO2017089890A1 ADC51
Monomethyl auristatin E
Microtubule (MT)
WO2017089890A1_ADC51 linker
[170]
WO2017089890A1 ADC52
Monomethyl auristatin E
Microtubule (MT)
WO2017089890A1_ADC52 linker
[170]
WO2017089890A1 ADC53
Monomethyl auristatin E
Microtubule (MT)
WO2017089890A1_ADC53 linker
[170]
WO2017089890A1 ADC54
Monomethyl auristatin F
Microtubule (MT)
WO2017089890A1_ADC54 linker
[170]
WO2017089890A1 ADC55
Monomethyl auristatin E
Microtubule (MT)
WO2017089890A1_ADC55 linker
[170]
WO2017089890A1 ADC76
Monomethyl auristatin F
Microtubule (MT)
WO2017089890A1_ADC76 linker
[170]
WO2017089890A1 ADC88
Monomethyl auristatin F
Microtubule (MT)
WO2017089890A1_ADC88 linker
[170]
WO2017089890A1 ADC89
Monomethyl auristatin E
Microtubule (MT)
WO2017089890A1_ADC89 linker
[170]
WO2017089890A1 ADC90
Monomethyl auristatin F
Microtubule (MT)
WO2017089890A1_ADC90 linker
[170]
WO2017089890A1 ADC91
Monomethyl auristatin E
Microtubule (MT)
WO2017089890A1_ADC91 linker
[170]
WO2017089890A1 ADC60
Monomethyl auristatin F
Microtubule (MT)
WO2017089890A1_ADC60 linker
[170]
WO2017089890A1 ADC61
Monomethyl auristatin E
Microtubule (MT)
WO2017089890A1_ADC61 linker
[170]
WO2017089890A1 ADC62
Monomethyl auristatin F
Microtubule (MT)
WO2017089890A1_ADC62 linker
[170]
WO2017089890A1 ADC63
Monomethyl auristatin E
Microtubule (MT)
WO2017089890A1_ADC63 linker
[170]
WO2017089890A1 ADC77
Monomethyl auristatin F
Microtubule (MT)
WO2017089890A1_ADC77 linker
[170]
WO2017089890A1 ADC21
Alpha-amanitin
DNA-directed RNA polymerase II subunit RPB2 (POLR2B); DNA-directed RNA polymerase III subunit RPC7 (POLR3G)
WO2017089890A1_ADC21 linker
[170]
WO2017089890A1 ADC22
Alpha-amanitin
DNA-directed RNA polymerase II subunit RPB2 (POLR2B); DNA-directed RNA polymerase III subunit RPC7 (POLR3G)
WO2017089890A1_ADC22 linker
[170]
WO2017089890A1 ADC56
Alpha-amanitin
DNA-directed RNA polymerase II subunit RPB2 (POLR2B); DNA-directed RNA polymerase III subunit RPC7 (POLR3G)
WO2017089890A1_ADC56 linker
[170]
WO2017089890A1 ADC57
Alpha-amanitin
DNA-directed RNA polymerase II subunit RPB2 (POLR2B); DNA-directed RNA polymerase III subunit RPC7 (POLR3G)
WO2017089890A1_ADC57 linker
[170]
WO2017089890A1 ADC58
Alpha-amanitin+Monomethyl auristatin E
DNA-directed RNA polymerase II subunit RPB2 (POLR2B); DNA-directed RNA polymerase III subunit RPC7 (POLR3G); Microtubule (MT)
WO2017089890A1_ADC58 linker
[170]
WO2017089890A1 ADC59
Alpha-amanitin+Monomethyl auristatin E
DNA-directed RNA polymerase II subunit RPB2 (POLR2B); DNA-directed RNA polymerase III subunit RPC7 (POLR3G); Microtubule (MT)
WO2017089890A1_ADC59 linker
[170]
WO2017089890A1 ADC78
Alpha-amanitin+Monomethyl auristatin E
DNA-directed RNA polymerase II subunit RPB2 (POLR2B); DNA-directed RNA polymerase III subunit RPC7 (POLR3G); Microtubule (MT)
WO2017089890A1_ADC78 linker
[170]
WO2018098269A2 conjugate 25
WO2018098269A2_conjugate 25 payload
Undisclosed
WO2018098269A2_conjugate 25 linker
[171]
WO2018098269A2 conjugate 28
WO2018098269A2_conjugate 28 payload
Undisclosed
WO2018098269A2_conjugate 28 linker
[171]
WO2018098269A2 conjugate 31A
WO2018098269A2_conjugate 31A payload
Undisclosed
WO2018098269A2_conjugate 31A linker
[171]
WO2018098269A2 conjugate 34A
WO2018098269A2_conjugate 34A payload
Undisclosed
WO2018098269A2_conjugate 34A linker
[171]
WO2018098269A2 conjugate 43A
WO2018098269A2_conjugate 43A payload
Undisclosed
WO2018098269A2_conjugate 43A linker
[171]
WO2018098269A2 conjugate 46A
WO2018098269A2_conjugate 46A payload
Undisclosed
WO2018098269A2_conjugate 46A linker
[171]
WO2018098269A2 conjugate 48
WO2018098269A2_conjugate 48 payload
Undisclosed
WO2018098269A2_conjugate 48 linker
[171]
WO2018098269A2 conjugate 50
WO2018098269A2_conjugate 50 payload
Undisclosed
WO2018098269A2_conjugate 50 linker
[171]
WO2018098269A2 conjugate 52
WO2018098269A2_conjugate 52 payload
Undisclosed
WO2018098269A2_conjugate 52 linker
[171]
WO2018098269A2 conjugate 67
WO2018098269A2_conjugate 67 payload
Undisclosed
WO2018098269A2_conjugate 67 linker
[171]
WO2018098269A2 conjugate 68
WO2018098269A2_conjugate 68 payload
Undisclosed
WO2018098269A2_conjugate 68 linker
[171]
WO2018098269A2 conjugate 46B
WO2018098269A2_conjugate 46B payload
Undisclosed
WO2018098269A2_conjugate 46B linker
[171]
WO2018098269A2 conjugate 43B
WO2018098269A2_conjugate 43B payload
Undisclosed
WO2018098269A2_conjugate 43B linker
[171]
WO2018098269A2 conjugate 34B
WO2018098269A2_conjugate 34B payload
Undisclosed
WO2018098269A2_conjugate 34B linker
[171]
WO2018098269A2 conjugate 31B
WO2018098269A2_conjugate 31B payload
Undisclosed
WO2018098269A2_conjugate 31B linker
[171]
WO2015004400A1 ADC-1
WO2015004400A1 ADC-1 payload
Undisclosed
WO2015004400A1 ADC-1 linker
[172]
WO2015004400A1 ADC-2
WO2015004400A1 ADC-2 payload
Undisclosed
WO2015004400A1 ADC-2 linker
[172]
WO2015004400A1 ADC-3
WO2015004400A1 ADC-3 payload
Undisclosed
WO2015004400A1 ADC-3 linker
[172]
WO2015004400A1 ADC-4
WO2015004400A1 ADC-4 payload
Undisclosed
WO2015004400A1 ADC-4 linker
[172]
WO2015004400A1 ADC-5
WO2015004400A1 ADC-5 payload
Undisclosed
WO2015004400A1 ADC-5 linker
[172]
WO2015004400A1 ADC-6
WO2015004400A1 ADC-6 payload
Undisclosed
WO2015004400A1 ADC-6 linker
[172]
WO2015004400A1 ADC-7
WO2015004400A1 ADC-7 payload
Undisclosed
WO2015004400A1 ADC-7 linker
[172]
WO2015004400A1 ADC-8
WO2015004400A1 ADC-8 payload
Undisclosed
WO2015004400A1 ADC-8 linker
[172]
Trastuzumab-Compound 9
Mertansine DM1
Microtubule (MT)
Trastuzumab-Compound 9 linker
[23]
Trastuzumab-Compound 17
Mertansine DM4
Microtubule (MT)
Trastuzumab-Compound 17 linker
[23]
Trastuzumab-Compound 25
Monomethyl auristatin E
Microtubule (MT)
Trastuzumab-Compound 25 linker
[23]
Trastuzumab-Compound 31
Auristatin 0101
Microtubule (MT)
Trastuzumab-Compound 31 linker
[23]
Trastuzumab-Compound 36
Monomethyl auristatin E
Microtubule (MT)
Trastuzumab-Compound 36 linker
[23]
Trastuzumab-Compound 43
PBD dimer
Human Deoxyribonucleic acid (hDNA)
Trastuzumab-Compound 43 linker
[23]
Trastuzumab-Compound 49
PBD dimer
Human Deoxyribonucleic acid (hDNA)
Trastuzumab-Compound 49 linker
[23]
Trastuzumab-Compound 55
Mertansine DM1
Microtubule (MT)
Trastuzumab-Compound 55 linker
[23]
Trastuzumab-Compound 59
Mertansine DM4
Microtubule (MT)
Trastuzumab-Compound 59 linker
[23]
Trastuzumab-Compound 64
Monomethyl auristatin E
Microtubule (MT)
Trastuzumab-Compound 64 linker
[23]
Trastuzumab-Compound 69
Monomethyl auristatin E
Microtubule (MT)
Trastuzumab-Compound 69 linker
[23]
Trastuzumab-Compound 74
PBD dimer
Human Deoxyribonucleic acid (hDNA)
Trastuzumab-Compound 74 linker
[23]
Trastuzumab-Compound 75
Monomethyl auristatin E
Microtubule (MT)
Trastuzumab-Compound 75 linker
[23]
Trastuzumab-Compound 76
Monomethyl auristatin E
Microtubule (MT)
Trastuzumab-Compound 76 linker
[23]
Trastuzumab-Compound 77
Mertansine DM1
Microtubule (MT)
Trastuzumab-Compound 77 linker
[23]
Trastuzumab-Compound 78
Auristatin 0101
Microtubule (MT)
Trastuzumab-Compound 78 linker
[23]
Trastuzumab-Compound 79
Auristatin 0101
Microtubule (MT)
Trastuzumab-Compound 79 linker
[23]
Trastuzumab-Compound 80
Mertansine DM4
Microtubule (MT)
Trastuzumab-Compound 80 linker
[23]
CN114917361A ADC-2
CN114917361A ADC-2 payload
Undisclosed
CN114917361A ADC-2 linker
[173]
CN114917361A ADC-7
CN114917361A ADC-7 payload
Undisclosed
CN114917361A ADC-7 linker
[173]
CN114917361A ADC-14
CN114917361A ADC-14 payload
Undisclosed
CN114917361A ADC-14 linker
[173]
CN114917361A ADC-17
CN114917361A ADC-17 payload
Undisclosed
CN114917361A ADC-17 linker
[173]
CN114917361A ADC-22
CN114917361A ADC-22 payload
Undisclosed
CN114917361A ADC-22 linker
[173]
CN114917361A ADC-28
CN114917361A ADC-28 payload
Undisclosed
CN114917361A ADC-28 linker
[173]
CN114917361A ADC-31
CN114917361A ADC-31 payload
Undisclosed
CN114917361A ADC-31 linker
[173]
CN114917361A ADC-34
CN114917361A ADC-34 payload
Undisclosed
CN114917361A ADC-34 linker
[173]
CN114917361A ADC-37
CN114917361A ADC-37 payload
Undisclosed
CN114917361A ADC-37 linker
[173]
CN114917361A ADC-42
CN114917361A ADC-42 payload
Undisclosed
CN114917361A ADC-42 linker
[173]
CN114917361A ADC-45
CN114917361A ADC-45 payload
Undisclosed
CN114917361A ADC-45 linker
[173]
CN114917361A ADC-48
CN114917361A ADC-48 payload
Undisclosed
CN114917361A ADC-48 linker
[173]
CN114917361A ADC-51
CN114917361A ADC-51 payload
Undisclosed
CN114917361A ADC-51 linker
[173]
CN114917361A ADC-56
CN114917361A ADC-56 payload
Undisclosed
CN114917361A ADC-56 linker
[173]
CN114917361A ADC-59
CN114917361A ADC-59 payload
Undisclosed
CN114917361A ADC-59 linker
[173]
CN114917361A ADC-62
CN114917361A ADC-62 payload
Undisclosed
CN114917361A ADC-62 linker
[173]
CN114917361A ADC-65
CN114917361A ADC-65 payload
Undisclosed
CN114917361A ADC-65 linker
[173]
CN114917361A ADC-68
CN114917361A ADC-68 payload
Undisclosed
CN114917361A ADC-68 linker
[173]
CN114917361A ADC-71
CN114917361A ADC-71 payload
Undisclosed
CN114917361A ADC-71 linker
[173]
CN114917361A ADC-74
CN114917361A ADC-74 payload
Undisclosed
CN114917361A ADC-74 linker
[173]
CN114917361A ADC-77
CN114917361A ADC-77 payload
Undisclosed
CN114917361A ADC-77 linker
[173]
CN114917361A ADC-80
CN114917361A ADC-80 payload
Undisclosed
CN114917361A ADC-80 linker
[173]
CN114917361A ADC-83
CN114917361A ADC-83 payload
Undisclosed
CN114917361A ADC-83 linker
[173]
CN109641910A ADC-1
CN109641910A ADC-1 payload
Undisclosed
CN109641910A ADC-1 linker
[174]
CN109641910A ADC-2
CN109641910A ADC-2 payload
Undisclosed
CN109641910A ADC-2 linker
[174]
CN109641910A ADC-3
CN109641910A ADC-3 payload
Undisclosed
CN109641910A ADC-3 linker
[174]
CN109641910A ADC-4
CN109641910A ADC-4 payload
Undisclosed
CN109641910A ADC-4 linker
[174]
CN109641910A ADC-5
CN109641910A ADC-5 payload
Undisclosed
CN109641910A ADC-5 linker
[174]
CN109641910A ADC-6
CN109641910A ADC-6 payload
Undisclosed
CN109641910A ADC-6 linker
[174]
CN109641910A ADC-7
CN109641910A ADC-7 payload
Undisclosed
CN109641910A ADC-7 linker
[174]
CN109641910A ADC-8
CN109641910A ADC-8 payload
Undisclosed
CN109641910A ADC-8 linker
[174]
CN109641910A ADC-9
CN109641910A ADC-9 payload
Undisclosed
CN109641910A ADC-9 linker
[174]
CN109641910A ADC-10
CN109641910A ADC-10 payload
Undisclosed
CN109641910A ADC-10 linker
[174]
CN109641910A ADC-11
CN109641910A ADC-11 payload
Undisclosed
CN109641910A ADC-11 linker
[174]
CN109641910A ADC-12
CN109641910A ADC-12 payload
Undisclosed
CN109641910A ADC-12 linker
[174]
CN109641910A ADC-13
CN109641910A ADC-13 payload
Undisclosed
CN109641910A ADC-13 linker
[174]
CN109641910A ADC-14
CN109641910A ADC-14 payload
Undisclosed
CN109641910A ADC-14 linker
[174]
CN109641910A ADC-15
CN109641910A ADC-15 payload
Undisclosed
CN109641910A ADC-15 linker
[174]
CN109641910A ADC-16
CN109641910A ADC-16 payload
Undisclosed
CN109641910A ADC-16 linker
[174]
CN105051032B ADC-I-5
CN105051032B_ADC-I-5 payload
Undisclosed
CN105051032B_ADC-I-5 linker
[175]
CN105051032B ADC-I-6
CN105051032B_ADC-I-6 payload
Undisclosed
CN105051032B_ADC-I-6 linker
[175]
CN105051032B ADC-I-7
CN105051032B_ADC-I-7 payload
Undisclosed
CN105051032B_ADC-I-7 linker
[175]
CN105051032B ADC-I-8
CN105051032B_ADC-I-8 payload
Undisclosed
CN105051032B_ADC-I-8 linker
[175]
CN105051032B ADC-I-9
CN105051032B_ADC-I-9 payload
Undisclosed
CN105051032B_ADC-I-9 linker
[175]
CN105051032B ADC-I-10
CN105051032B_ADC-I-10 payload
Undisclosed
CN105051032B_ADC-I-10 linker
[175]
CN105051032B ADC-I-11
CN105051032B_ADC-I-11 payload
Undisclosed
CN105051032B_ADC-I-11 linker
[175]
CN105051032B ADC-I-12
CN105051032B_ADC-I-12 payload
Undisclosed
CN105051032B_ADC-I-12 linker
[175]
CN105051032B ADC-I-13
CN105051032B_ADC-I-13 payload
Undisclosed
CN105051032B_ADC-I-13 linker
[175]
CN105051032B ADC-I-14
CN105051032B_ADC-I-14 payload
Undisclosed
CN105051032B_ADC-I-14 linker
[175]
CN105051032B ADC-I-15
CN105051032B_ADC-I-15 payload
Undisclosed
CN105051032B_ADC-I-15 linker
[175]
CN105051032B ADC-I-16
CN105051032B_ADC-I-16 payload
Undisclosed
CN105051032B_ADC-I-16 linker
[175]
CN105051032B ADC-I-17
CN105051032B_ADC-I-17 payload
Undisclosed
CN105051032B_ADC-I-17 linker
[175]
CN105051032B ADC-I-18
CN105051032B_ADC-I-18 payload
Undisclosed
CN105051032B_ADC-I-18 linker
[175]
CN105051032B ADC-I-19
CN105051032B_ADC-I-19 payload
Undisclosed
CN105051032B_ADC-I-19 linker
[175]
CN105051032B ADC-I-20
CN105051032B_ADC-I-20 payload
Undisclosed
CN105051032B_ADC-I-20 linker
[175]
CN105051032B ADC-I-21
CN105051032B_ADC-I-21 payload
Undisclosed
CN105051032B_ADC-I-21 linker
[175]
CN105051032B ADC-I-22
CN105051032B_ADC-I-22 payload
Undisclosed
CN105051032B_ADC-I-22 linker
[175]
CN105051032B ADC-I-23
CN105051032B_ADC-I-23 payload
Undisclosed
CN105051032B_ADC-I-23 linker
[175]
CN105051032B ADC-I-24
CN105051032B_ADC-I-24 payload
Undisclosed
CN105051032B_ADC-I-24 linker
[175]
CN105051032B ADC-I-25
CN105051032B_ADC-I-25 payload
Undisclosed
CN105051032B_ADC-I-25 linker
[175]
CN105051032B ADC-I-26
CN105051032B_ADC-I-26 payload
Undisclosed
CN105051032B_ADC-I-26 linker
[175]
CN105051032B ADC-I-27
CN105051032B_ADC-I-27 payload
Undisclosed
CN105051032B_ADC-I-27 linker
[175]
CN105051032B ADC-I-28
CN105051032B_ADC-I-28 payload
Undisclosed
CN105051032B_ADC-I-28 linker
[175]
CN105051032B ADC-I-29
CN105051032B_ADC-I-29 payload
Undisclosed
CN105051032B_ADC-I-29 linker
[175]
CN105051032B ADC-I-30
CN105051032B_ADC-I-30 payload
Undisclosed
CN105051032B_ADC-I-30 linker
[175]
CN105051032B ADC-I-31
CN105051032B_ADC-I-31 payload
Undisclosed
CN105051032B_ADC-I-31 linker
[175]
CN105051032B ADC-I-32
CN105051032B_ADC-I-32 payload
Undisclosed
CN105051032B_ADC-I-32 linker
[175]
CN105051032B ADC-I-33
CN105051032B_ADC-I-33 payload
Undisclosed
CN105051032B_ADC-I-33 linker
[175]
CN105051032B ADC-I-34
CN105051032B_ADC-I-34 payload
Undisclosed
CN105051032B_ADC-I-34 linker
[175]
CN105051032B ADC-I-35
CN105051032B_ADC-I-35 payload
Undisclosed
CN105051032B_ADC-I-35 linker
[175]
CN105051032B ADC-I-36
CN105051032B_ADC-I-36 payload
Undisclosed
CN105051032B_ADC-I-36 linker
[175]
CN105051032B ADC-I-37
CN105051032B_ADC-I-37 payload
Undisclosed
CN105051032B_ADC-I-37 linker
[175]
CN105051032B ADC-I-38
CN105051032B_ADC-I-38 payload
Undisclosed
CN105051032B_ADC-I-38 linker
[175]
CN105051032B ADC-I-39
CN105051032B_ADC-I-39 payload
Undisclosed
CN105051032B_ADC-I-39 linker
[175]
CN105051032B ADC-I-40
CN105051032B_ADC-I-40 payload
Undisclosed
CN105051032B_ADC-I-40 linker
[175]
CN105051032B ADC-I-41
CN105051032B_ADC-I-41 payload
Undisclosed
CN105051032B_ADC-I-41 linker
[175]
WO2014068443A1 ADC1
WO2014068443A1_ADC1 payload
Undisclosed
WO2014068443A1_ADC1 linker
[176]
WO2014068443A1 ADC2
WO2014068443A1_ADC2 payload
Undisclosed
WO2014068443A1_ADC2 linker
[176]
WO2014068443A1 ADC3
WO2014068443A1_ADC3 payload
Undisclosed
WO2014068443A1_ADC3 linker
[176]
WO2014068443A1 ADC4
WO2014068443A1_ADC4 payload
Undisclosed
WO2014068443A1_ADC4 linker
[176]
WO2014068443A1 ADC5
WO2014068443A1_ADC5 payload
Undisclosed
WO2014068443A1_ADC5 linker
[176]
WO2014068443A1 ADC6
WO2014068443A1_ADC6 payload
Undisclosed
WO2014068443A1_ADC6 linker
[176]
WO2014068443A1 ADC7
WO2014068443A1_ADC7 payload
Undisclosed
WO2014068443A1_ADC7 linker
[176]
WO2014068443A1 ADC8
WO2014068443A1_ADC8 payload
Undisclosed
WO2014068443A1_ADC8 linker
[176]
WO2014068443A1 ADC9
WO2014068443A1_ADC9 payload
Undisclosed
WO2014068443A1_ADC9 linker
[176]
WO2014068443A1 ADC10
WO2014068443A1_ADC10 payload
Undisclosed
WO2014068443A1_ADC10 linker
[176]
WO2014068443A1 ADC11
WO2014068443A1_ADC11 payload
Undisclosed
WO2014068443A1_ADC11 linker
[176]
WO2014068443A1 ADC12
WO2014068443A1_ADC12 payload
Undisclosed
WO2014068443A1_ADC12 linker
[176]
WO2014068443A1 ADC13
WO2014068443A1_ADC13 payload
Undisclosed
WO2014068443A1_ADC13 linker
[176]
WO2014068443A1 ADC14
WO2014068443A1_ADC14 payload
Undisclosed
WO2014068443A1_ADC14 linker
[176]
WO2014068443A1 ADC15
WO2014068443A1_ADC15 payload
Undisclosed
WO2014068443A1_ADC15 linker
[176]
WO2014068443A1 ADC16
WO2014068443A1_ADC16 payload
Undisclosed
WO2014068443A1_ADC16 linker
[176]
WO2014068443A1 ADC17
WO2014068443A1_ADC17 payload
Undisclosed
WO2014068443A1_ADC17 linker
[176]
WO2014068443A1 ADC18
WO2014068443A1_ADC18 payload
Undisclosed
WO2014068443A1_ADC18 linker
[176]
WO2014068443A1 ADC19
WO2014068443A1_ADC19 payload
Undisclosed
WO2014068443A1_ADC19 linker
[176]
WO2014068443A1 ADC20
WO2014068443A1_ADC20 payload
Undisclosed
WO2014068443A1_ADC20 linker
[176]
WO2014068443A1 ADC21
WO2014068443A1_ADC21 payload
Undisclosed
WO2014068443A1_ADC21 linker
[176]
WO2014068443A1 ADC22
WO2014068443A1_ADC22 payload
Undisclosed
WO2014068443A1_ADC22 linker
[176]
WO2014068443A1 ADC23
WO2014068443A1_ADC23 payload
Undisclosed
WO2014068443A1_ADC23 linker
[176]
WO2014068443A1 ADC24
WO2014068443A1_ADC24 payload
Undisclosed
WO2014068443A1_ADC24 linker
[176]
WO2014068443A1 ADC25
WO2014068443A1_ADC25 payload
Undisclosed
WO2014068443A1_ADC25 linker
[176]
WO2014068443A1 ADC26
WO2014068443A1_ADC26 payload
Undisclosed
WO2014068443A1_ADC26 linker
[176]
WO2014068443A1 ADC27
WO2014068443A1_ADC27 payload
Undisclosed
WO2014068443A1_ADC27 linker
[176]
WO2014068443A1 ADC28
WO2014068443A1_ADC28 payload
Undisclosed
WO2014068443A1_ADC28 linker
[176]
WO2014068443A1 ADC29
WO2014068443A1_ADC29 payload
Undisclosed
WO2014068443A1_ADC29 linker
[176]
WO2014068443A1 ADC30
WO2014068443A1_ADC30 payload
Undisclosed
WO2014068443A1_ADC30 linker
[176]
WO2014068443A1 ADC31
WO2014068443A1_ADC31 payload
Undisclosed
WO2014068443A1_ADC31 linker
[176]
WO2014068443A1 ADC32
WO2014068443A1_ADC32 payload
Undisclosed
WO2014068443A1_ADC32 linker
[176]
WO2014068443A1 ADC33
WO2014068443A1_ADC33 payload
Undisclosed
WO2014068443A1_ADC33 linker
[176]
WO2014068443A1 ADC34
WO2014068443A1_ADC34 payload
Undisclosed
WO2014068443A1_ADC34 linker
[176]
WO2014068443A1 ADC35
WO2014068443A1_ADC35 payload
Undisclosed
WO2014068443A1_ADC35 linker
[176]
WO2014068443A1 ADC36
WO2014068443A1_ADC36 payload
Undisclosed
WO2014068443A1_ADC36 linker
[176]
WO2014068443A1 ADC37
WO2014068443A1_ADC37 payload
Undisclosed
WO2014068443A1_ADC37 linker
[176]
WO2014068443A1 ADC38
WO2014068443A1_ADC38 payload
Undisclosed
WO2014068443A1_ADC38 linker
[176]
WO2014068443A1 ADC39
WO2014068443A1_ADC39 payload
Undisclosed
WO2014068443A1_ADC39 linker
[176]
WO2014068443A1 ADC40
WO2014068443A1_ADC40 payload
Undisclosed
WO2014068443A1_ADC40 linker
[176]
WO2014068443A1 ADC41
WO2014068443A1_ADC41 payload
Undisclosed
WO2014068443A1_ADC41 linker
[176]
WO2014068443A1 ADC42
WO2014068443A1_ADC42 payload
Undisclosed
WO2014068443A1_ADC42 linker
[176]
WO2014068443A1 ADC43
WO2014068443A1_ADC43 payload
Undisclosed
WO2014068443A1_ADC43 linker
[176]
WO2014068443A1 ADC44
WO2014068443A1_ADC44 payload
Undisclosed
WO2014068443A1_ADC44 linker
[176]
WO2014068443A1 ADC45
WO2014068443A1_ADC45 payload
Undisclosed
WO2014068443A1_ADC45 linker
[176]
WO2014068443A1 ADC46
WO2014068443A1_ADC46 payload
Undisclosed
WO2014068443A1_ADC46 linker
[176]
WO2014068443A1 ADC47
WO2014068443A1_ADC47 payload
Undisclosed
WO2014068443A1_ADC47 linker
[176]
WO2014068443A1 ADC48
WO2014068443A1_ADC48 payload
Undisclosed
WO2014068443A1_ADC48 linker
[176]
WO2014068443A1 ADC49
WO2014068443A1_ADC49 payload
Undisclosed
WO2014068443A1_ADC49 linker
[176]
WO2014068443A1 ADC50
WO2014068443A1_ADC50 payload
Undisclosed
WO2014068443A1_ADC50 linker
[176]
WO2014068443A1 ADC51
WO2014068443A1_ADC51 payload
Undisclosed
WO2014068443A1_ADC51 linker
[176]
WO2014068443A1 ADC52
WO2014068443A1_ADC52 payload
Undisclosed
WO2014068443A1_ADC52 linker
[176]
WO2014068443A1 ADC53
WO2014068443A1_ADC53 payload
Undisclosed
WO2014068443A1_ADC53 linker
[176]
WO2014068443A1 ADC54
WO2014068443A1_ADC54 payload
Undisclosed
WO2014068443A1_ADC54 linker
[176]
WO2014068443A1 ADC55
WO2014068443A1_ADC55 payload
Undisclosed
WO2014068443A1_ADC55 linker
[176]
WO2014068443A1 ADC56
WO2014068443A1_ADC56 payload
Undisclosed
WO2014068443A1_ADC56 linker
[176]
WO2014068443A1 ADC57
WO2014068443A1_ADC57 payload
Undisclosed
WO2014068443A1_ADC57 linker
[176]
WO2014068443A1 ADC58
WO2014068443A1_ADC58 payload
Undisclosed
WO2014068443A1_ADC58 linker
[176]
WO2014068443A1 ADC59
WO2014068443A1_ADC59 payload
Undisclosed
WO2014068443A1_ADC59 linker
[176]
WO2014068443A1 ADC60
WO2014068443A1_ADC60 payload
Undisclosed
WO2014068443A1_ADC60 linker
[176]
WO2014068443A1 ADC61
WO2014068443A1_ADC61 payload
Undisclosed
WO2014068443A1_ADC61 linker
[176]
WO2014068443A1 ADC62
WO2014068443A1_ADC62 payload
Undisclosed
WO2014068443A1_ADC62 linker
[176]
WO2014068443A1 ADC63
WO2014068443A1_ADC63 payload
Undisclosed
WO2014068443A1_ADC63 linker
[176]
WO2014068443A1 ADC64
WO2014068443A1_ADC64 payload
Undisclosed
WO2014068443A1_ADC64 linker
[176]
WO2014068443A1 ADC65
WO2014068443A1_ADC65 payload
Undisclosed
WO2014068443A1_ADC65 linker
[176]
WO2014068443A1 ADC66
WO2014068443A1_ADC66 payload
Undisclosed
WO2014068443A1_ADC66 linker
[176]
WO2014068443A1 ADC67
WO2014068443A1_ADC67 payload
Undisclosed
WO2014068443A1_ADC67 linker
[176]
WO2014068443A1 ADC68
WO2014068443A1_ADC68 payload
Undisclosed
WO2014068443A1_ADC68 linker
[176]
WO2014068443A1 ADC69
WO2014068443A1_ADC69 payload
Undisclosed
WO2014068443A1_ADC69 linker
[176]
WO2014068443A1 ADC70
WO2014068443A1_ADC70 payload
Undisclosed
WO2014068443A1_ADC70 linker
[176]
WO2014068443A1 ADC71
WO2014068443A1_ADC71 payload
Undisclosed
WO2014068443A1_ADC71 linker
[176]
WO2014068443A1 ADC72
WO2014068443A1_ADC72 payload
Undisclosed
WO2014068443A1_ADC72 linker
[176]
WO2014068443A1 ADC73
WO2014068443A1_ADC73 payload
Undisclosed
WO2014068443A1_ADC73 linker
[176]
WO2014068443A1 ADC74
WO2014068443A1_ADC74 payload
Undisclosed
WO2014068443A1_ADC74 linker
[176]
WO2014068443A1 ADC75
WO2014068443A1_ADC75 payload
Undisclosed
WO2014068443A1_ADC75 linker
[176]
WO2014068443A1 ADC76
WO2014068443A1_ADC76 payload
Undisclosed
WO2014068443A1_ADC76 linker
[176]
WO2014068443A1 ADC77
WO2014068443A1_ADC77 payload
Undisclosed
WO2014068443A1_ADC77 linker
[176]
WO2014068443A1 ADC78
WO2014068443A1_ADC78 payload
Undisclosed
WO2014068443A1_ADC78 linker
[176]
WO2014068443A1 ADC79
WO2014068443A1_ADC79 payload
Undisclosed
WO2014068443A1_ADC79 linker
[176]
WO2014068443A1 ADC80
WO2014068443A1_ADC80 payload
Undisclosed
WO2014068443A1_ADC80 linker
[176]
WO2014068443A1 ADC81
WO2014068443A1_ADC81 payload
Undisclosed
WO2014068443A1_ADC81 linker
[176]
WO2014068443A1 ADC82
WO2014068443A1_ADC82 payload
Undisclosed
WO2014068443A1_ADC82 linker
[176]
WO2014068443A1 ADC83
WO2014068443A1_ADC83 payload
Undisclosed
WO2014068443A1_ADC83 linker
[176]
WO2014068443A1 ADC84
WO2014068443A1_ADC84 payload
Undisclosed
WO2014068443A1_ADC84 linker
[176]
Trastuzumab-dTSPEG-MMAF
Monomethyl auristatin F
Microtubule (MT)
dTSPEG
[177]
H2-921
Undisclosed
Undisclosed
D5 linker
[178]
H2-921
SB743921
Kinesin spindle protein (KSP)
CN118987256A, H2-921, Linker
[179]
T-PBA
PBD-based payload 37b3
Undisclosed
MC-Val-Ala-OH linker
[180]
US20250018051A1 IaⅦ
US20250018038A1+IaⅥ+payload
Undisclosed
Mc-Val-Ala-PABC
[181]
US20250018051A1 IaⅦ
US20250018038A1+IaⅦ+payload
Undisclosed
Mc-Val-Cit-PABC
[181]
T-Ed9
Ed9
DNA topoisomerase I (TOP1)
Mc-Gly-Gly-Phe-Gly
[182]
T-VEd9
Ed9
DNA topoisomerase I (TOP1)
Mc-Val-Ala
[182]
Tras-DXd-MTL1
DX-8951 derivative (DXd); MTT5
Undisclosed
Gly-Mal-Gly-Gly-Phe-Gly
[183]
Trastuzumab-MMAU (DAR4)
Glucuronyl-monomethyl-auristatin E (MMAU)
Microtubule (MT)
Val-Ser (beta-Glc) cleavable linker
[184]
Trastuzumab-MMAU (DAR8)
Glucuronyl-monomethyl-auristatin E (MMAU)
Microtubule (MT)
Val-Ser (beta-Glc) cleavable linker
[184]
38850783 ADC 1
Mertansine DM1
Microtubule (MT)
Dimaleimide linker 1
[185]
38850783 ADC 2
Mertansine DM1
Microtubule (MT)
Dimaleimide linker 2
[185]
38850783 ADC 3
Mertansine DM1
Microtubule (MT)
Dimaleimide linker 3
[185]
38850783 ADC 4
Mertansine DM1
Microtubule (MT)
Dimaleimide linker 4
[185]
38850783 ADC 5
Mertansine DM1
Microtubule (MT)
Dimaleimide linker 5
[185]
39235949 anti-HER2-1
Undisclosed
Undisclosed
Undisclosed
[186]
39235949 anti-HER2-2
Undisclosed
Undisclosed
Undisclosed
[186]
39235949 anti-HER2-3
Undisclosed
Undisclosed
Undisclosed
[186]
39235949 anti-HER2-4
Undisclosed
Undisclosed
Undisclosed
[186]
39235949 anti-HER2-5
Undisclosed
Undisclosed
Undisclosed
[186]
39410752 ADC (1)
Pyrene
Undisclosed
Mal-Exo-EVC
[187]
39410752 ADC (2)
Pyrene
Undisclosed
Mal-Exo-EEVC
[187]
39410752 ADC (3)
Pyrene
Undisclosed
Mc-Val-Cit-PABC
[187]
39410752 ADC (4)
Pyrene
Undisclosed
Mc-EVC-PAB
[187]
39410752 ADC (5)
Monomethyl auristatin E
Microtubule (MT)
Mal-Exo-EVC
[187]
39410752 ADC (6)
Monomethyl auristatin E
Microtubule (MT)
Mal-Exo-EEVC
[187]
39410752 ADC (7)
Exatecan
DNA topoisomerase 1 (TOP1)
Mal-Exo-EEVC
[187]
39410752 ADC (8)
Monomethyl auristatin E
Microtubule (MT)
Mal-Exo-EEVC
[187]
39410752 ADC (9)
Exatecan
DNA topoisomerase 1 (TOP1)
Mal-Exo-EEVC
[187]
39410752 ADC (10)
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
[187]
39410752 ADC (11)
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
[187]
39410752 ADC (12)
Monomethyl auristatin E
Microtubule (MT)
Mc-EVC-PAB
[187]
37492000 ADC 6a (4h)
Monomethyl auristatin E
Microtubule (MT)
TetraDVP based linker 1a
[188]
37492000 ADC 6b (4h)
Monomethyl auristatin E
Microtubule (MT)
TetraDVP based linker 1b
[188]
37492000 ADC 6c (4h)
Monomethyl auristatin E
Microtubule (MT)
TetraDVP based linker 1c
[188]
37492000 ADC 6d (4h)
Monomethyl auristatin E
Microtubule (MT)
TetraDVP based linker 1d
[188]
37492000 ADC 7a (4h)
Monomethyl auristatin E
Microtubule (MT)
TetraDVP based linker 2a
[188]
37492000 ADC 7b (4h)
Monomethyl auristatin E
Microtubule (MT)
TetraDVP based linker 2b
[188]
37492000 ADC 7c (4h)
Monomethyl auristatin E
Microtubule (MT)
TetraDVP based linker 2c
[188]
37492000 ADC 7d (4h)
Monomethyl auristatin E
Microtubule (MT)
TetraDVP based linker 2d
[188]
37492000 ADC 6a (24h)
Monomethyl auristatin E
Microtubule (MT)
TetraDVP based linker 1a
[188]
37492000 ADC 6b (24h)
Monomethyl auristatin E
Microtubule (MT)
TetraDVP based linker 1b
[188]
37492000 ADC 6c (24h)
Monomethyl auristatin E
Microtubule (MT)
TetraDVP based linker 1c
[188]
37492000 ADC 6d (24h)
Monomethyl auristatin E
Microtubule (MT)
TetraDVP based linker 1d
[188]
37492000 ADC 7a (24h)
Monomethyl auristatin E
Microtubule (MT)
TetraDVP based linker 2a
[188]
37492000 ADC 7b (24h)
Monomethyl auristatin E
Microtubule (MT)
TetraDVP based linker 2b
[188]
37492000 ADC 7c (24h)
Monomethyl auristatin E
Microtubule (MT)
TetraDVP based linker 2c
[188]
37492000 ADC 7d (24h)
Monomethyl auristatin E
Microtubule (MT)
TetraDVP based linker 2d
[188]
Tras-Exa
Exatecan
DNA topoisomerase 1 (TOP1)
AB2 self-immolative dendritic scaffold
[189]
Tras-Bel
Belotecan
DNA topoisomerase 1 (TOP1)
AB2 self-immolative dendritic scaffold
[189]
DEVD ADC
Exatecan
DNA topoisomerase 1 (TOP1)
MC-DEVD-PAB
[190]
36924655 ADC 28
Monomethyl auristatin E
Microtubule (MT)
Undisclosed
[191]
36924655 ADC 29
Monomethyl auristatin E
Microtubule (MT)
Undisclosed
[191]
36924655 ADC 30
Monomethyl auristatin E
Microtubule (MT)
Undisclosed
[191]
36924655 ADC 31
Monomethyl auristatin E
Microtubule (MT)
Undisclosed
[191]
36924655 ADC 5
Monomethyl auristatin E
Microtubule (MT)
Undisclosed
[191]
36924655 ADC 6
Monomethyl auristatin E
Microtubule (MT)
Undisclosed
[191]
36924655 ADC 7
Monomethyl auristatin E
Microtubule (MT)
Undisclosed
[191]
36924655 ADC 8
Monomethyl auristatin E
Microtubule (MT)
Undisclosed
[191]
36924655 ADC 9
Monomethyl auristatin E
Microtubule (MT)
Undisclosed
[191]
36924655 ADC 10
Monomethyl auristatin E
Microtubule (MT)
Undisclosed
[191]
36924655 ADC 11
Monomethyl auristatin E
Microtubule (MT)
Undisclosed
[191]
36924655 ADC 12
Monomethyl auristatin E
Microtubule (MT)
Undisclosed
[191]
36924655 ADC 13
Monomethyl auristatin E
Microtubule (MT)
Undisclosed
[191]
36924655 ADC 14
Monomethyl auristatin E
Microtubule (MT)
Undisclosed
[191]
36924655 ADC 15
Monomethyl auristatin E
Microtubule (MT)
Undisclosed
[191]
Trastuzumab-DXd (38003245)
DX-8951 derivative (DXd)
DNA topoisomerase 1 (TOP1)
Undisclosed
[192]
37307297 ADC 1
FD-1
Undisclosed
Mc-Val-Cit-PABC
[193]
37307297 ADC 2
FD-1
Undisclosed
Undisclosed
[193]
37307297 ADC 3
FD-1
Undisclosed
Undisclosed
[193]
37307297 ADC 4
FD-1
Undisclosed
Undisclosed
[193]
37307297 ADC 5
FD-1
Undisclosed
Undisclosed
[193]
37307297 ADC 6
FD-1
Undisclosed
Undisclosed
[193]
37307297 ADC 7
FD-1
Undisclosed
Undisclosed
[193]
37307297 ADC 8
FD-1
Undisclosed
Undisclosed
[193]
37307297 ADC 9
FD-1
Undisclosed
Undisclosed
[193]
37307297 ADC 12
FD-2
Undisclosed
Undisclosed
[193]
37307297 ADC 13
FD-2
Undisclosed
Undisclosed
[193]
37307297 ADC 14
FD-3
Undisclosed
Undisclosed
[193]
Trastuzumab-LplA-MMAE
Monomethyl auristatin E
Microtubule (MT)
DBCO-Val-Cit-PABC
[194]
Tras-16a
14a 39321689
Undisclosed
Mc-Gly-Gly-Phe-Gly
[195]
Tras-16b
14b 39321689
Undisclosed
Mc-Gly-Gly-Phe-Gly
[195]
37486969 ADC 36
STING Agonist 6
Undisclosed
Undisclosed
[196]
37486969 ADC 37
STING Agonist 6
Undisclosed
Undisclosed
[196]
37486969 ADC 38
STING Agonist 6
Undisclosed
Undisclosed
[196]
37486969 ADC 39
STING Agonist 4
Undisclosed
Undisclosed
[196]
37486969 ADC 40
STING Agonist 4
Undisclosed
Undisclosed
[196]
37486969 ADC 42
STING Agonist 15
Undisclosed
Undisclosed
[196]
37486969 ADC 43
STING Agonist 15
Undisclosed
Undisclosed
[196]
37486969 ADC 44
STING Agonist 15
Undisclosed
Undisclosed
[196]
37486969 ADC 45
STING Agonist 15
Undisclosed
Undisclosed
[196]
37486969 ADC 46
STING Agonist 15
Undisclosed
Undisclosed
[196]
T-VCR 6a
Vincristine (VCR)
Undisclosed
Mc-Val-Cit-PABC
[197]
T-VCR 6b
Vincristine (VCR)
Undisclosed
Mc-Val-Cit-PABC
[197]
37217025 ADC-1
TLR7/8 agonist 1
Undisclosed
MT-VC-PABC
[198]
37217025 ADC-2
TLR7/8 agonist 20h
Undisclosed
MT-VC-PABC
[198]
37917829 ADC 2
RIPK2 PROTAC
Undisclosed
Undisclosed
[199]
37828728 ADC 1
Exatecan
DNA topoisomerase 1 (TOP1)
P5 (OEt)-VC-PAB
[200]
37828728 ADC 2
Exatecan
DNA topoisomerase 1 (TOP1)
P5 (PEG2)-VC-PAB
[200]
37828728 ADC 3
Exatecan
DNA topoisomerase 1 (TOP1)
P5 (PEG12)-VC-PAB
[200]
37828728 ADC 4
Exatecan
DNA topoisomerase 1 (TOP1)
P5 (PEG12)-VA-PAB
[200]
37828728 ADC 5
Exatecan
DNA topoisomerase 1 (TOP1)
P5 (PEG24)-VC-PAB
[200]
37828728 ADC 6
Exatecan
DNA topoisomerase 1 (TOP1)
Mc-Val-Cit-PABC
[200]
37828728 ADC 7
Exatecan
DNA topoisomerase 1 (TOP1)
P5 (PEG12)-VA
[200]
37828728 ADC 8
Exatecan
DNA topoisomerase 1 (TOP1)
P5- (PEG12)
[200]
HER2-14
CPTS-1
Undisclosed
Mal-Val-Ala-PAB
[201]
HER2-16
CPTS-1
Undisclosed
Mc-Val-Cit-PABC
[201]
HER2-17
WL-14
Undisclosed
Mal-Val-Ala-PAB
[201]
HER2-18
WL-14
Undisclosed
Mc-Val-Cit-PABC
[201]
Trastuzumab- (VC-PABC-MMAE)2
Monomethyl auristatin E
Microtubule (MT)
Undisclosed
[202]
Trastuzumab-DM1 (K248)
Mertansine DM1
Microtubule (MT)
Undisclosed
[203]
Trastuzumab-MMAE (K248)
Monomethyl auristatin E
Microtubule (MT)
Undisclosed
[203]
Trastuzumab-MMAE (K288)
Monomethyl auristatin E
Microtubule (MT)
Undisclosed
[203]
38888299 ADC 1
Monomethyl auristatin E
Microtubule (MT)
Tuneable thiol exchange linker 1
[204]
38888299 ADC 2
Monomethyl auristatin E
Microtubule (MT)
Tuneable thiol exchange linker 2
[204]
38888299 ADC 3
Monomethyl auristatin E
Microtubule (MT)
Tuneable thiol exchange linker 3
[204]
Trastu-AzaNIRII-MMAE
Monomethyl auristatin E
Microtubule (MT)
azaNIRII-BCN-PEG4-VAC-PAB
[205]
Tra-CL2A-FL118 (11)
Undisclosed
Undisclosed
CL2A
[206]
39337633 2ICy7-Ab
Diiodinated heptamethine cyanine
Undisclosed
Undisclosed
[207]
Cy7-Ab
Heptamethine cyanine
Undisclosed
Undisclosed
[207]
[111In]In-ADCS
Undisclosed
Undisclosed
Undisclosed
[208]
[111In]In-AD
Undisclosed
Undisclosed
Undisclosed
[208]
HER2-25
Tolllike receptor 7/8 agonist 18
Undisclosed
Undisclosed
[209]
HER2-26
Tolllike receptor 7/8 agonist 18
Undisclosed
Undisclosed
[209]
37222285 ADC 1
Auri E
Undisclosed
sulfatase-responsive linker
[210]
Tras-DSPEK248
Undisclosed
Undisclosed
Undisclosed
[211]
Tmab-VcMMAE-SMCC-DM1
Monomethyl auristatin E; Maytansinoid DM1
Undisclosed
Mc-Val-Cit-PABC; Succinimidyl-4- (N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
[212]
TZ-dSA3-2
diABZI STING agonist 3
Undisclosed
Undisclosed
[213]
TZ-dSA3-4
diABZI STING agonist 3
Undisclosed
Undisclosed
[213]
TZ-dSA3-8
diABZI STING agonist 3
Undisclosed
Undisclosed
[213]
TZ-dSA3-12
diABZI STING agonist 3
Undisclosed
Undisclosed
[213]
Anti-HER2_VCGP-Dex
Dexamethasone
Glucocorticoid receptor (NR3C1)
Mal-ValCitGlyPro-OH
[214]
Tras-2C
Undisclosed
Undisclosed
Undisclosed
[84]
Tras-5C
Undisclosed
Undisclosed
Undisclosed
[84]
HC-A118C-1a
Monomethyl auristatin E
Microtubule (MT)
Undisclosed
[215]
HC-A118C-1b
Monomethyl auristatin E
Microtubule (MT)
Undisclosed
[215]
HC-A118C-2
Monomethyl auristatin E
Microtubule (MT)
Undisclosed
[215]
HC-A118C-3
Monomethyl auristatin E
Microtubule (MT)
Undisclosed
[215]
HC-A118C-4
Monomethyl auristatin E
Microtubule (MT)
Undisclosed
[215]
HC-A140C-1a
Monomethyl auristatin E
Microtubule (MT)
Undisclosed
[215]
HC-A140C-1b
Monomethyl auristatin E
Microtubule (MT)
Undisclosed
[215]
HC-A140C-2
Monomethyl auristatin E
Microtubule (MT)
Undisclosed
[215]
HC-A140C-3
Monomethyl auristatin E
Microtubule (MT)
Undisclosed
[215]
HC-A140C-4
Monomethyl auristatin E
Microtubule (MT)
Undisclosed
[215]
HC-E258C-1a
Monomethyl auristatin E
Microtubule (MT)
Undisclosed
[215]
HC-E258C-1b
Monomethyl auristatin E
Microtubule (MT)
Undisclosed
[215]
HC-E258C-2
Monomethyl auristatin E
Microtubule (MT)
Undisclosed
[215]
HC-E258C-3
Monomethyl auristatin E
Microtubule (MT)
Undisclosed
[215]
HC-E258C-4
Monomethyl auristatin E
Microtubule (MT)
Undisclosed
[215]
HC-S400C-1a
Monomethyl auristatin E
Microtubule (MT)
Undisclosed
[215]
HC-S400C-1b
Monomethyl auristatin E
Microtubule (MT)
Undisclosed
[215]
HC-S400C-2
Monomethyl auristatin E
Microtubule (MT)
Undisclosed
[215]
HC-S400C-3
Monomethyl auristatin E
Microtubule (MT)
Undisclosed
[215]
HC-S400C-4
Monomethyl auristatin E
Microtubule (MT)
Undisclosed
[215]
LC-K149C-1a
Monomethyl auristatin E
Microtubule (MT)
Undisclosed
[215]
LC-K149C-1b
Monomethyl auristatin E
Microtubule (MT)
Undisclosed
[215]
LC-K149C-2
Monomethyl auristatin E
Microtubule (MT)
Undisclosed
[215]
LC-K149C-3
Monomethyl auristatin E
Microtubule (MT)
Undisclosed
[215]
LC-K149C-4
Monomethyl auristatin E
Microtubule (MT)
Undisclosed
[215]
LC-V205C-1a
Monomethyl auristatin E
Microtubule (MT)
Undisclosed
[215]
LC-V205C-1b
Monomethyl auristatin E
Microtubule (MT)
Undisclosed
[215]
LC-V205C-2
Monomethyl auristatin E
Microtubule (MT)
Undisclosed
[215]
LC-V205C-3
Monomethyl auristatin E
Microtubule (MT)
Undisclosed
[215]
LC-V205C-4
Monomethyl auristatin E
Microtubule (MT)
Undisclosed
[215]
WT ADC
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
[216]
Trastuzumab-TCO-Pot-Tz
Porphyrin (Por)-tetrazine (Tz)
Undisclosed
Undisclosed
[217]
Trastuzumab 20
PBD-butanamide derivative
Undisclosed
Mc-Val-Ala
[218]
Antibody-fluorophore conjugate FCY (11)
Biorthogonal azide 9
Undisclosed
Undisclosed
[219]
CN119343374A ADC-S109
Undisclosed
Undisclosed
Undisclosed
[90]
CN119343374A ADC-S110
Undisclosed
Undisclosed
Undisclosed
[90]
CN119343374A ADC-S111
Undisclosed
Undisclosed
Undisclosed
[90]
CN119343374A ADC-S423
Undisclosed
Undisclosed
Undisclosed
[90]
CN119343374A ADC-S426
Undisclosed
Undisclosed
Undisclosed
[90]
CN119343374A ADC-TRA41C
Undisclosed
Undisclosed
Undisclosed
[90]
Trastuzumab-Example 1
CN119343152A 1C1-Example1 Payload
Microtubule (MT)
CN119343152A 1C1-Example1 Linker
[220]
Trastuzumab-Example 2
CN119343152A 1C1-Example1 Payload
Microtubule (MT)
CN119343152A 1C1-Example2 Linker
[220]
Trastuzumab-Example 3
CN119343152A 1C1-Example3 Payload1; CN119343152A 1C1-Example3 Payload2
Undisclosed
CN119343152A 1C1-Example3 Linker
[220]
Trastuzumab-Example 4
CN119343152A 1C1-Example1 Payload; CN119343152A 1C1-Example4 Payload
Undisclosed
CN119343152A 1C1-Example4 Linker
[220]
Trastuzumab-Example 5
CN119343152A Trastuzumab-Example5 Payload
Microtubule (MT)
CN119343152A 1C1-Example1 Linker
[220]
Trastuzumab-Example 6
CN119343152A Trastuzumab-Example6 Payload
DNA topoisomerase I (TOP1)
CN119343152A 1C1-Example1 Linker
[220]
Trastuzumab-Example 7
CN119343152A Trastuzumab-Example6 Payload
DNA topoisomerase I (TOP1)
CN119343152A Trastuzumab-Example7 Linker
[220]
Trastuzumab-Example 8
DX-8951 derivative (DXd)
DNA topoisomerase 1 (TOP1)
CN119343152A Trastuzumab-Example8 Linker
[220]
Trastuzumab-GDP-D-P2/P4-P4-GGFG-Dxd
DX-8951 derivative (DXd)
DNA topoisomerase 1 (TOP1)
CN119343152A Trastuzumab-GDP-D-P2/P4-P4-GGFG-Dxd Linker
[221]
Trastuzumab-GDP-K-P2/P4-P4-GGFG-Dxd
DX-8951 derivative (DXd)
DNA topoisomerase 1 (TOP1)
CN119326907A Trastuzumab-GDP-D-P2/P4-P4-GGFG-Dxd Linker
[221]
Trastuzumab-GDP-D-P2/P8-P4-GGFG-Dxd
DX-8951 derivative (DXd)
DNA topoisomerase 1 (TOP1)
CN119326907A Trastuzumab-GDP-D-P2/P8-P4-GGFG-Dxd Linker
[221]
Trastuzumab-GDP-D-P1/P2-P4-GGFG-Dxd
DX-8951 derivative (DXd)
DNA topoisomerase 1 (TOP1)
CN119326907A Trastuzumab-GDP-D-P2/P4-P4-GGFG-Dxd Linker
[221]
Trastuzumab-GDP-D-P1/P1-P4-GGFG-Dxd
DX-8951 derivative (DXd)
DNA topoisomerase 1 (TOP1)
CN119326907A Trastuzumab-GDP-D-P1/P1-P4-GGFG-Dxd Linker
[221]
Trastuzumab-GDP-D-P2/P4-P1-GGFG-Dxd
DX-8951 derivative (DXd)
DNA topoisomerase 1 (TOP1)
CN119326907A Trastuzumab-GDP-D-P2/P4-P1-GGFG-Dxd Linker
[221]
Trastuzumab-GDP-D-P2/P4-P2-GGFG-Dxd
DX-8951 derivative (DXd)
DNA topoisomerase 1 (TOP1)
CN119326907A Trastuzumab-GDP-D-P2/P4-P2-GGFG-Dxd Linker
[221]
Trastuzumab-GDP-D-P1/P1-P1-GGFG-Dxd
DX-8951 derivative (DXd)
DNA topoisomerase 1 (TOP1)
CN119326907A Trastuzumab-GDP-D-P1/P1-P1-GGFG-Dxd Linker
[221]
Trastuzumab-GDP-D-P1/P1-P2-GGFG-Dxd
DX-8951 derivative (DXd)
DNA topoisomerase 1 (TOP1)
CN119326907A Trastuzumab-GDP-D-P1/P1-P2-GGFG-Dxd Linker
[221]
Trastuzumab-GDP-D-P1/P1-C2-GGFG-Dxd
DX-8951 derivative (DXd)
DNA topoisomerase 1 (TOP1)
CN119326907A Trastuzumab-GDP-D-P1/P1-C2-GGFG-Dxd Linker
[221]
Trastuzumab-GDP-D-P1/P2-C2-GGFG-Dxd
DX-8951 derivative (DXd)
DNA topoisomerase 1 (TOP1)
CN119326907A Trastuzumab-GDP-D-P1/P2-C2-GGFG-Dxd Linker
[221]
Trastuzumab-GDP-D-P1/P2-P1-GGFG-Dxd
DX-8951 derivative (DXd)
DNA topoisomerase 1 (TOP1)
CN119326907A Trastuzumab-GDP-D-P1/P2-P1-GGFG-Dxd Linker
[221]
Trastuzumab-GDP-N-P1/P2-P1-GGFG-Dxd
DX-8951 derivative (DXd)
DNA topoisomerase 1 (TOP1)
CN119326907A Trastuzumab-GDP-N-P1/P2-P1-GGFG-Dxd Linker
[221]
Trastuzumab-GDP-N-P1/P1-P1-GGFG-Dxd
DX-8951 derivative (DXd)
DNA topoisomerase 1 (TOP1)
CN119326907A Trastuzumab-GDP-N-P1/P1-P1-GGFG-Dxd Linker
[221]
Trastuzumab-GDP-D-P2/P2-P2-GGFG-Dxd
DX-8951 derivative (DXd)
DNA topoisomerase 1 (TOP1)
Trastuzumab-GDP-D-P2/P2-P2-GGFG-Dxd Linker
[221]
AB185-ADL10-D8
D8 payload
Undisclosed
6-Maleimidocaproic acid
[222]
AB185-ADL10-D1
D1 payload
Undisclosed
6-Maleimidocaproic acid
[222]
AB185-ADL5-D17
D17 payload
Undisclosed
Mc-Val-Cit-PAB (Qamine) linker
[222]
AB185-ADL1-D16
D16 payload
Undisclosed
Mc-Val-Cit-PABC
[222]
AB185-ADL5-D26
D26 payload
Undisclosed
Mc-Val-Cit-PAB (Qamine) linker
[222]
AB185-ADL1-D14
D14 payload
Undisclosed
Mc-Val-Cit-PABC
[222]
AB185-ADL5-D15
D15 payload
Undisclosed
Mc-Val-Cit-PAB (Qamine) linker
[222]
AB185-ADL5-D11
D11 payload
Undisclosed
Mc-Val-Cit-PAB (Qamine) linker
[222]
AB185-ADL1-D33
D33 payload
Undisclosed
Mc-Val-Cit-PABC
[222]
AB185-ADL1-D22
D22 payload
Undisclosed
Mc-Val-Cit-PABC
[222]
AB185-ADL12-D2
D2 payload
Undisclosed
Mal- (CH2)6- linker
[222]
AB185-ADL1-D13
D13 payload
Undisclosed
Mc-Val-Cit-PABC
[222]
AB185-ADL5-D19
D19 payload
Undisclosed
Mc-Val-Cit-PAB (Qamine) linker
[222]
AB185-ADL5-D10
D10 payload
Undisclosed
Mc-Val-Cit-PAB (Qamine) linker
[222]
AB185-ADL6-D9
D9 payload
Undisclosed
Mc-Val-Cit-PABC
[222]
AB185-ADL5-D2 4.14
D2 payload
Undisclosed
Mc-Val-Cit-PAB (Qamine) linker
[222]
AB185-ADL1-D8
D8 payload
Undisclosed
Mc-Val-Cit-PABC
[222]
AB185-ADL15-D2
D2 payload
Undisclosed
Mal-CH2CH2-O-CH2CH2- linker
[222]
AB185-ADL12-D20
D20 payload
Undisclosed
Mal- (CH2)6- linker
[222]
AB185-ADL12-D1 3.3
D1 payload
Undisclosed
Mal- (CH2)6- linker
[222]
AB185-ADL5-D2 8.5
D2 payload
Undisclosed
Mc-Val-Cit-PAB (Qamine) linker
[222]
AB185-ADL6-D1
D1 payload
Undisclosed
Mc-Val-Cit-PABC
[222]
AB185-ADL12-D1 3
D1 payload
Undisclosed
Mal- (CH2)6- linker
[222]
AB185-ADL12-D22
D22 payload
Undisclosed
Mal- (CH2)6- linker
[222]
AB185-ADL1-D4 8
D4 payload
Undisclosed
Mc-Val-Cit-PABC
[222]
AB185-ADL15-D1
D1 payload
Undisclosed
Mal-CH2CH2-O-CH2CH2- linker
[222]
AB185-ADL14-D1
D14 payload
Undisclosed
Mal-CH2CH2- linker
[222]
AB185-ADL1-D4 2.8
undisclosed
Undisclosed
Mc-Val-Cit-PABC
[222]
AB185-ADL1-D1
D1 payload
Undisclosed
Mc-Val-Cit-PABC
[222]
AB185-ADL5-D25
D25 payload
Undisclosed
Mc-Val-Cit-PABC
[222]
AB185-ADL12-D21
D21 payload
Undisclosed
Mal- (CH2)6- linker
[222]
AB185-ADL1-D18
D18 payload
Undisclosed
Mc-Val-Cit-PABC
[222]
AB185-ADL1-D12
D12 payload
Undisclosed
Mc-Val-Cit-PABC
[222]
AB185-ADL13-D4
D4 payload
Undisclosed
B-glucuronide linker
[222]
AB185-ADL1-D5
D5 payload
Undisclosed
Mc-Val-Cit-PABC
[222]
AB185-ADL1-D3
D3 Payload payload
Undisclosed
Undisclosed
[222]
CN118924912A anti-HER2 ADC1
CN118924912A anti-HER2 ADC1 Payload
Undisclosed
CN118924912A anti-HER2 ADC1 Linker
[223]
CN118924912A anti-HER2 ADC2
CN118924912A anti-HER2 ADC2 Payload
Undisclosed
CN118924912A anti-HER2 ADC1 Linker
[223]
CN118924912A anti-HER2 ADC3
CN118924912A anti-HER2 ADC3 Payload
Undisclosed
CN118924912A anti-HER2 ADC1 Linker
[223]
CN118924912A anti-HER2 ADC4
CN118924912A anti-HER2 ADC4 Payload
Undisclosed
CN118924912A anti-HER2 ADC1 Linker
[223]
CN118924912A anti-HER2 ADC5
CN118924912A anti-HER2 ADC5 Payload
Undisclosed
CN118924912A anti-HER2 ADC1 Linker
[223]
CN118924912A anti-HER2 ADC6
CN118924912A anti-HER2 ADC6 Payload
Undisclosed
CN118924912A anti-HER2 ADC1 Linker
[223]
CN118924912A anti-HER2 ADC7
CN118924912A anti-HER2 ADC7 Payload
Undisclosed
CN118924912A anti-HER2 ADC1 Linker
[223]
CN118924912A anti-HER2 ADC8
CN118924912A anti-HER2 ADC8 Payload
Undisclosed
CN118924912A anti-HER2 ADC1 Linker
[223]
CN118924912A anti-HER2 ADC9
CN118924912A anti-HER2 ADC9 Payload
Undisclosed
CN118924912A anti-HER2 ADC1 Linker
[223]
CN118924912A anti-HER2 ADC10
CN118924912A anti-HER2 ADC10 Payload
Undisclosed
CN118924912A anti-HER2 ADC1 Linker
[223]
CN118924912A anti-HER2 ADC11
CN118924912A anti-HER2 ADC11 Payload
Undisclosed
CN118924912A anti-HER2 ADC1 Linker
[223]
CN118924912A anti-HER2 ADC12
CN118924912A anti-HER2 ADC12 Payload
Undisclosed
CN118924912A anti-HER2 ADC1 Linker
[223]
CN118924912A anti-HER2 ADC13
CN118924912A anti-HER2 ADC13 Payload
Undisclosed
CN118924912A anti-HER2 ADC1 Linker
[223]
CN118924912A anti-HER2 ADC14
CN118924912A anti-HER2 ADC14 Payload
Undisclosed
CN118924912A anti-HER2 ADC1 Linker
[223]
CN118924912A anti-HER2 ADC15
CN118924912A anti-HER2 ADC15 Payload
Undisclosed
CN118924912A anti-HER2 ADC1 Linker
[223]
CN118924912A anti-HER2 ADC16
CN118924912A anti-HER2 ADC16 Payload
Undisclosed
CN118924912A anti-HER2 ADC1 Linker
[223]
CN118924912A anti-HER2 ADC17
CN118924912A anti-HER2 ADC17 Payload
Undisclosed
CN118924912A anti-HER2 ADC1 Linker
[223]
CN118924912A anti-HER2 ADC18
CN118924912A anti-HER2 ADC18 Payload
Undisclosed
CN118924912A anti-HER2 ADC1 Linker
[223]
CN118924912A anti-HER2 ADC19
CN118924912A anti-HER2 ADC19 Payload
Undisclosed
CN118924912A anti-HER2 ADC1 Linker
[223]
CN118924912A anti-HER2 ADC20
CN118924912A anti-HER2 ADC20 Payload
Undisclosed
CN118924912A anti-HER2 ADC1 Linker
[223]
CN118401256A ADC 1
Monomethyl auristatin E
Microtubule (MT)
Allenamide-Amcap-Val-Cit-PABC
[224]
CN118401256A ADC 2
Monomethyl auristatin E
Microtubule (MT)
Maleimido-caproyl-Val-Cit-PABC
[224]
CN117750982A ADC58
CN117750982A ADC58 Payload
Undisclosed
CN117750982A ADC58 Linker
[225]
CN117750982A ADC59
CN117750982A ADC58 Payload
Undisclosed
CN117750982A ADC59 Linker
[225]
CN117750982A ADC60
CN117750982A ADC58 Payload
Undisclosed
CN117750982A ADC60 Linker
[225]
CN117750982A ADC61
CN117750982A ADC58 Payload
Undisclosed
CN117750982A ADC61 Linker
[225]
CN117750982A ADC62
CN117750982A ADC62 Payload
Undisclosed
CN117750982A ADC58 Linker
[225]
CN117750982A ADC63
CN117750982A ADC62 Payload
Undisclosed
CN117750982A ADC59 Linker
[225]
CN117750982A ADC64
CN117750982A ADC62 Payload
Undisclosed
CN117750982A ADC60 Linker
[225]
CN117750982A ADC65
CN117750982A ADC62 Payload
Undisclosed
CN117750982A ADC61 Linker
[225]
CN114615999B ADC-1
CN114615999B ADC-1 Payload
Undisclosed
CN114615999B ADC-1 Linker
[226]
CN114615999B ADC-2
CN114615999B ADC-1 Payload
Undisclosed
CN114615999B ADC-2 Linker
[226]
CN114615999B ADC-3
CN114615999B ADC-3 Payload
Undisclosed
CN114615999B ADC-2 Linker
[226]
CN114615999B ADC-4
CN114615999B ADC-1 Payload
Undisclosed
CN114615999B ADC-1 Linker
[226]
CN114615999B ADC-5
CN114615999B ADC-3 Payload
Undisclosed
CN114615999B ADC-2 Linker
[226]
US20230109312A1 ADC with 4 MMAF
Monomethyl auristatin F
Microtubule (MT)
US20230109312A1 ADC with 4 MMAF Linker
[227]
US20220226492A1 Immunoconjugate A
undisclosed
Undisclosed
Undisclosed
[228]
US20220226492A1 Immunoconjugate B
undisclosed
Undisclosed
Undisclosed
[228]
US20220226492A1 Immunoconjugate C
undisclosed
Undisclosed
Undisclosed
[228]
US20220226492A1 Immunoconjugate D
undisclosed
Undisclosed
Undisclosed
[228]
US20220226492A1 Immunoconjugate E
undisclosed
Undisclosed
Undisclosed
[228]
US20220226492A1 Immunoconjugate F
undisclosed
Undisclosed
Undisclosed
[228]
US20220226492A1 Immunoconjugate G
undisclosed
Undisclosed
Undisclosed
[228]
US20220226492A1 Immunoconjugate H
undisclosed
Undisclosed
Undisclosed
[228]
US20220226492A1 Immunoconjugate I
undisclosed
Undisclosed
Undisclosed
[228]
US20220226492A1 Immunoconjugate J
undisclosed
Undisclosed
Undisclosed
[228]
US20220226492A1 Immunoconjugate L
undisclosed
Undisclosed
Undisclosed
[228]
US20220226492A1 Immunoconjugate M
undisclosed
Undisclosed
Undisclosed
[228]
US20220226492A1 Immunoconjugate N
undisclosed
Undisclosed
Undisclosed
[228]
US20220226492A1 Immunoconjugate O
undisclosed
Undisclosed
Undisclosed
[228]
US20220226492A1 Immunoconjugate P
undisclosed
Undisclosed
Undisclosed
[228]
US20220226492A1 Immunoconjugate Q
undisclosed
Undisclosed
Undisclosed
[228]
US20220226492A1 Immunoconjugate R
undisclosed
Undisclosed
Undisclosed
[228]
US20220226492A1 Immunoconjugate S
undisclosed
Undisclosed
Undisclosed
[228]
US20220226492A1 Immunoconjugate T
undisclosed
Undisclosed
Undisclosed
[228]
US20220226492A1 Immunoconjugate U
undisclosed
Undisclosed
Undisclosed
[228]
US20220226492A1 Immunoconjugate V
undisclosed
Undisclosed
Undisclosed
[228]
US20220226492A1 Immunoconjugate K1
undisclosed
Undisclosed
Undisclosed
[228]
US20220226492A1 Immunoconjugate R1
undisclosed
Undisclosed
Undisclosed
[228]
CN115515644A ADC-1-b
CN115515644A ADC-1-a Payload
Undisclosed
CN115515644A ADC-1-a Linker
[229]
CN115515644A ADC-2-b
CN115515644A ADC-1-a Payload
Undisclosed
CN115515644A ADC-2-a Linker
[229]
CN115515644A ADC-3-b
CN115515644A ADC-1-a Payload
Undisclosed
CN115515644A ADC-3-a Linker
[229]
CN115515644A ADC-4-b
CN115515644A ADC-1-a Payload
Undisclosed
CN115515644A ADC-4-a Linker
[229]
CN115515644A ADC-5-b
CN115515644A ADC-1-a Payload
Undisclosed
CN115515644A ADC-5-a Linker
[229]
JP7623413B2 ExampleADC9
Undisclosed
Undisclosed
Undisclosed
[230]
JP7623413B2 ExampleADC45
Undisclosed
Undisclosed
Undisclosed
[230]
US12144865B2 1e
Undisclosed
Undisclosed
Undisclosed
[231]
US12144865B2 2e
Undisclosed
Undisclosed
Undisclosed
[231]
US12144865B2 5e
Undisclosed
Undisclosed
Undisclosed
[231]
US12144865B2 6e
Undisclosed
Undisclosed
Undisclosed
[231]
US12144865B2 8e
Undisclosed
Undisclosed
Undisclosed
[231]
US12144865B2 11e
Undisclosed
Undisclosed
Undisclosed
[231]
US12144865B2 12e
Undisclosed
Undisclosed
Undisclosed
[231]
US12144865B2 13e
Undisclosed
Undisclosed
Undisclosed
[231]
US12144865B2 14e
Undisclosed
Undisclosed
Undisclosed
[231]
US12144865B2 16e
Undisclosed
Undisclosed
Undisclosed
[231]
US12144865B2 17e
Undisclosed
Undisclosed
Undisclosed
[231]
US12144865B2 18e
Undisclosed
Undisclosed
Undisclosed
[231]
US12144865B2 19e
Undisclosed
Undisclosed
Undisclosed
[231]
US12144865B2 21e
Undisclosed
Undisclosed
Undisclosed
[231]
US12144865B2 22e
Undisclosed
Undisclosed
Undisclosed
[231]
US12144865B2 23e
Undisclosed
Undisclosed
Undisclosed
[231]
US12144865B2 24e
Undisclosed
Undisclosed
Undisclosed
[231]
US12144865B2 25e
Undisclosed
Undisclosed
Undisclosed
[231]
US12144865B2 26e
Undisclosed
Undisclosed
Undisclosed
[231]
US12144865B2 27e
Undisclosed
Undisclosed
Undisclosed
[231]
US12144865B2 28e
Undisclosed
Undisclosed
Undisclosed
[231]
US12144865B2 29e
Undisclosed
Undisclosed
Undisclosed
[231]
US12144865B2 30e
Undisclosed
Undisclosed
Undisclosed
[231]
US12144865B2 35e
Undisclosed
Undisclosed
Undisclosed
[231]
US12144865B2 36e
Undisclosed
Undisclosed
Undisclosed
[231]
US12144865B2 37e
Undisclosed
Undisclosed
Undisclosed
[231]
US12144865B2 38e
Undisclosed
Undisclosed
Undisclosed
[231]
US12144865B2 39e
Undisclosed
Undisclosed
Undisclosed
[231]
US12144865B2 40e
Undisclosed
Undisclosed
Undisclosed
[231]
US12144865B2 41e
Undisclosed
Undisclosed
Undisclosed
[231]
US12144865B2 42e
Undisclosed
Undisclosed
Undisclosed
[231]
US12144865B2 43e
Undisclosed
Undisclosed
Undisclosed
[231]
US12144865B2 44e
Undisclosed
Undisclosed
Undisclosed
[231]
Trastuzumab-LD1
seco-DUBA
Human Deoxyribonucleic acid (hDNA)
Trastuzumab-LD1-LINKER
[235]
Trastuzumab-LD3
seco-DUBA
Human Deoxyribonucleic acid (hDNA)
Trastuzumab-LD3-LINKER
[235]
Trastuzumab-LD4
seco-DUBA
Human Deoxyribonucleic acid (hDNA)
Trastuzumab-LD1-LINKER
[235]
Trastuzumab-LD5
seco-DUBA
Human Deoxyribonucleic acid (hDNA)
Trastuzumab-LD1-LINKER
[235]
Trastuzumab-LD6
seco-DUBA
Human Deoxyribonucleic acid (hDNA)
Trastuzumab-LD1-LINKER
[235]
Trastuzumab-LD7
Undisclosed
Undisclosed
Trastuzumab-LD7-LINKER
[235]
Trastuzumab-LD8
Undisclosed
Undisclosed
Trastuzumab-LD8-LINKER
[235]
AU2017363246B2 Conjugate28
AU2017363246B2+Conjugate28+Payload
Undisclosed
Undisclosed
[236]
AU2017363246B2 Conjugate31A
AU2017363246B2+Conjugate31+Payload
Undisclosed
AU2017363246B2+Conjugate31+Linker
[236]
AU2017363246B2 Conjugate31B
AU2017363246B2+Conjugate31+Payload
Undisclosed
AU2017363246B2+Conjugate31+Linker
[236]
AU2017363246B2 Conjugate34A
AU2017363246B2+Conjugate34+Payload
Undisclosed
AU2017363246B2+Conjugate34+Linker
[236]
AU2017363246B2 Conjugate34B
AU2017363246B2+Conjugate34+Payload
Undisclosed
AU2017363246B2+Conjugate34+Linker
[236]
AU2017363246B2 Conjugate43A
AU2017363246B2+Conjugate43+Payload
Undisclosed
AU2017363246B2+Conjugate43+Linker
[236]
AU2017363246B2 Conjugate43B
AU2017363246B2+Conjugate43+Payload
Undisclosed
AU2017363246B2+Conjugate43+Linker
[236]
AU2017363246B2 Conjugate46A
AU2017363246B2+Conjugate46+Payload
Undisclosed
AU2017363246B2+Conjugate46+Linker
[236]
AU2017363246B2 Conjugate46B
AU2017363246B2+Conjugate46+Payload
Undisclosed
AU2017363246B2+Conjugate46+Linker
[236]
AU2017363246B2 Conjugate48
AU2017363246B2+Conjugate48+Payload
Undisclosed
AU2017363246B2+Conjugate48+Linker
[236]
AU2017363246B2 Conjugate52
AU2017363246B2+Conjugate52+Payload
Undisclosed
AU2017363246B2+Conjugate52+Linker
[236]
AU2017363246B2 Conjugate67
AU2017363246B2+Conjugate67+Payload
Undisclosed
AU2017363246B2+Conjugate67+Linker
[236]
AU2017363246B2 Conjugate68
AU2017363246B2+Conjugate68+Payload
Undisclosed
AU2017363246B2+Conjugate68+Linker
[236]
AU2017363246B2 Conjugate25
AU2017363246B2+Conjugate25+Payload
Undisclosed
AU2017363246B2+Conjugate25+Linker
[236]
AU2023226367A1-1
RU20241285-1-payload
Undisclosed
RU20241285-1-linker
[237]
AU2023226367A1-2
U-030
DNA topoisomerase I (TOP1)
RU20241285-1-linker
[237]
AU2023226367A1-3
Auristatin E
Microtubule (MT)
RU20241285-3-linker
[237]
AU2023226367A1-4
RU20241285-4-payload
Undisclosed
RU20241285-4-linker
[237]
AU2023226367A1-5
RU20241285-5-payload
Undisclosed
RU20241285-1-linker
[237]
AU2023226367A1-6
RU20241285-6-payload
Undisclosed
RU20241285-6-linker
[237]
AU2023226367A1-7
Monomethyl auristatin E
Microtubule (MT)
RU20241285-7-linker
[237]
AU2023226367A1-8
Monomethyl auristatin E
Microtubule (MT)
RU20241285-8-linker
[237]
AU2023226367A1-9
RU20241285-9-payload
Undisclosed
RU20241285-9-linker
[237]
AU2023226367A1-10
RU20241285-10-payload
Undisclosed
RU20241285-10-linker
[237]
AU2023226367A1-11
DX-8951 derivative (DXd)
DNA topoisomerase 1 (TOP1)
RU20241285-10-linker
[237]
AU2023226367A1-12
DX-8951 derivative (DXd)
DNA topoisomerase 1 (TOP1)
RU20241285-12-linker
[237]
AU2023226367A1-13
DX-8951 derivative (DXd)
DNA topoisomerase 1 (TOP1)
RU20241285-13-linker
[237]
AU2023226367A1-14
Eribulin
Microtubule (MT)
RU20241285-8-linker
[237]
AU2023226367A1-15
RU20241285-15-payload
Undisclosed
RU20241285-15-linker
[237]
AU2023226367A1-16
Eribulin
Microtubule (MT)
EP4487874A1-18linker
[237]
AU2023226367A1-17
Eribulin
Microtubule (MT)
RU20241285-17-linker
[237]
AU2023226367A1-18
Eribulin
Microtubule (MT)
RU20241285-18-linker
[237]
AU2023226367A1-19
Auristatin E
Microtubule (MT)
RU20241285-19-linker
[237]
AU2023226367A1-20
Topo1 inhibitor A
DNA topoisomerase I (TOP1)
EP4487874A1-13linker
[237]
AU2023226367A1-21
RU20241285-21-payload
Undisclosed
RU20241285-21-linker
[237]
AU2023226367A1-22
RU20241285-22-payload
Undisclosed
RU20241285-22-linker
[237]
AU2023226367A1-23
RU20241285-23-payload
DNA topoisomerase I (TOP1)
RU20241285-23-linker
[237]
AU2023226367A1-24
RU20241285-23-payload
DNA topoisomerase I (TOP1)
RU20241285-24-linker
[237]
ZA202500114A-ADC-6
Undisclosed
Undisclosed
Undisclosed
[238]
ZA202500415A-ADC Example 1
NMT inhibitor 1
N-Myristoyltransferase (NMT)
ZA202500415A-ADC-Example-1-Linker
[239]
ZA202500415A-ADC Example 5
NMT inhibitor 26
N-Myristoyltransferase (NMT)
ZA202500415A-ADC-Example-1-Linker
[239]
ZA202500415A-ADC Example 6
ZA202500415A-ADC-Example-6-payload
N-Myristoyltransferase (NMT)
ZA202500415A-ADC-Example-1-Linker
[239]
ZA202500415A-ADC Example 7
NMT inhibitor 1
N-Myristoyltransferase (NMT)
Mc-Gly-Gly-Phe-Gly
[239]
HER2-ADC-001
DL001-payload; DL003-payload
Undisclosed
DL001-Linker; DL003-Linker
[240]
HER2-ADC-002
DL007-payload; DL003-payload
Undisclosed
DL007-Linker; DL003-Linker
[240]
HER2-ADC-003
DL007-payload; DL003-payload
Undisclosed
DL007-Linker; DL003-Linker
[240]
HER2-ADC-004
DL007-payload; DL002-payload
Undisclosed
DL007-Linker; DL002-Linker
[240]
HER2-ADC-005
DL012-payload; DL003-payload
Undisclosed
DL012-Linker; DL003-Linker
[240]
HER2-ADC-006
DL012-payload; DL003-payload
Undisclosed
DL012-Linker; DL003-Linker
[240]
HER2-ADC-007
DL012-payload; DL003-payload
Undisclosed
DL012-Linker; DL003-Linker
[240]
HER2-ADC-008
DL012-payload; DL003-payload
Undisclosed
DL012-Linker; DL003-Linker
[240]
HER2-ADC-009
DL012-payload; DL003-payload
Undisclosed
DL012-Linker; DL003-Linker
[240]
HER2-ADC-010
DL014-payload; DL003-payload
Undisclosed
DL014-Linker; DL003-Linker
[240]
HER2-ADC-011
DL014-payload; DL003-payload
Undisclosed
DL014-Linker; DL003-Linker
[240]
HER2-ADC-012
DL014-payload; DL003-payload
Undisclosed
DL014-Linker; DL003-Linker
[240]
HER2-ADC-013
DL012-payload; DL003-payload
Undisclosed
DL012-Linker; DL003-Linker
[240]
HER2-ADC-014
DL017-payload; DL003-payload
Undisclosed
DL017-Linker; DL003-Linker
[240]
HER2-ADC-015
DL017-payload; DL003-payload
Undisclosed
DL017-Linker; DL003-Linker
[240]
HER2-DL012-DAR2
DL012-payload
Undisclosed
DL012-Linker
[240]
HER2-DL003-DAR8
DL003-payload
Undisclosed
DL003-Linker
[240]
Trastuzumab N221 (WT)-MMAF #1
Monomethyl auristatin F
Microtubule (MT)
Undisclosed
[241]
Trastuzumab N221 (WT)-MMAF #2
Monomethyl auristatin F
Microtubule (MT)
Undisclosed
[241]
Trastuzumab N221 (GDLN)-MMAF
Monomethyl auristatin F
Microtubule (MT)
Undisclosed
[241]
Tras-LN-MMAF
Monomethyl auristatin F
Microtubule (MT)
Undisclosed
[241]
Tras.D221N-MMAF (HEK GDLN)
Monomethyl auristatin F
Microtubule (MT)
Undisclosed
[241]
Tras.D221N-MMAF (HEK WT)
Monomethyl auristatin F
Microtubule (MT)
Undisclosed
[241]
WO2023047090A1-MMAE ADC
Monomethyl auristatin E
Microtubule (MT)
Undisclosed
[94]
WO2023047090A1-SN-38 reagent (11) ADC
Undisclosed
Undisclosed
Undisclosed
[94]
WO2023047090A1-SN-38 reagent (13) ADC
Undisclosed
Undisclosed
Undisclosed
[94]
AU2020291014A1 IC-1
AU2020291014A1-Payload-2
Undisclosed
Aminobenzazepine-linker Formula II-2
[242]
AU2020291014A1 IC-2
AU2020291014A1-Payload-3
Undisclosed
Aminobenzazepine-linker Formula II-3
[242]
AU2020291014A1 IC-3
AU2020291014A1-Payload-2
Undisclosed
Aminobenzazepine-linker Formula II-4
[242]
AU2020291014A1 IC-4
AU2020291014A1-Payload-2
Undisclosed
Aminobenzazepine-linker Formula II-5
[242]
AU2020291014A1 IC-5
Undisclosed
Undisclosed
Undisclosed
[242]
AU2020291014A1 IC-6
Undisclosed
Undisclosed
Undisclosed
[242]
AU2020291014A1 IC-7
Undisclosed
Undisclosed
Undisclosed
[242]
AU2020291014A1 IC-8
AU2020291014A1-Payload-70
Undisclosed
Aminobenzazepine-linker Formula II-15
[242]
AU2020291014A1 IC-10
AU2020291014A1-Payload-16
Undisclosed
Aminobenzazepine-linker Formula II-16
[242]
AU2020291014A1 IC-11
AU2020291014A1-Payload-17
Undisclosed
Aminobenzazepine-linker Formula II-17
[242]
AU2020291014A1 IC-12
AU2020291014A1-Payload-18
Undisclosed
Aminobenzazepine-linker Formula II-17
[242]
AU2020291014A1 IC-13
AU2020291014A1-Payload-19
Undisclosed
Aminobenzazepine-linker Formula II-17
[242]
AU2020291014A1 IC-14
AU2020291014A1-Payload-70
Undisclosed
Aminobenzazepine-linker Formula II-17
[242]
AU2020291014A1 IC-16
Undisclosed
Undisclosed
Undisclosed
[242]
AU2020291014A1 IC-17
AU2020291014A1-Payload-70
Undisclosed
Aminobenzazepine-linker Formula II-22
[242]
AU2020291014A1 IC-18
AU2020291014A1-Payload-25
Undisclosed
Aminobenzazepine-linker Formula II-25
[242]
AU2020291014A1 IC-19
AU2020291014A1-Payload-27
Undisclosed
Aminobenzazepine-linker Formula II-27
[242]
AU2020291014A1 IC-20
AU2020291014A1-Payload-70
Undisclosed
Aminobenzazepine-linker Formula II-31
[242]
AU2020291014A1 IC-21
Undisclosed
Undisclosed
Undisclosed
[242]
AU2020291014A1 IC-22
AU2020291014A1-Payload-33
Undisclosed
Aminobenzazepine-linker Formula II-33
[242]
AU2020291014A1 IC-23
AU2020291014A1-Payload-35
Undisclosed
Aminobenzazepine-linker Formula II-33
[242]
AU2020291014A1 IC-24
AU2020291014A1-Payload-36
Undisclosed
Aminobenzazepine-linker Formula II-36
[242]
AU2020291014A1 IC-25
Undisclosed
Undisclosed
Undisclosed
[242]
AU2020291014A1 IC-26
Undisclosed
Undisclosed
Undisclosed
[242]
AU2020291014A1 IC-27
AU2020291014A1-Payload-34
Undisclosed
Aminobenzazepine-linker Formula II-34
[242]
AU2020291014A1 IC-28
AU2020291014A1-Payload-39
Undisclosed
Undisclosed
[242]
AU2020291014A1 IC-29
AU2020291014A1-Payload-40
Undisclosed
Undisclosed
[242]
AU2020291014A1 IC-30
AU2020291014A1-Payload-41
Undisclosed
Undisclosed
[242]
AU2020291014A1 IC-31
AU2020291014A1-Payload-42
Undisclosed
Aminobenzazepine-linker Formula II-42
[242]
AU2020291014A1 IC-32
undisclosed
Undisclosed
Undisclosed
[242]
AU2020291014A1 IC-33
undisclosed
Undisclosed
Undisclosed
[242]
AU2020291014A1 IC-34
undisclosed
Undisclosed
Undisclosed
[242]
AU2020291014A1 IC-35
undisclosed
Undisclosed
Undisclosed
[242]
AU2020291014A1 IC-38
AU2020291014A1-Payload-49
Undisclosed
Undisclosed
[242]
AU2020291014A1 IC-40
undisclosed
Undisclosed
Undisclosed
[242]
AU2020291014A1 IC-41
undisclosed
Undisclosed
Undisclosed
[242]
AU2020291014A1 IC-42
undisclosed
Undisclosed
Undisclosed
[242]
AU2020291014A1 IC-43
undisclosed
Undisclosed
Undisclosed
[242]
AU2020291014A1 IC-44
undisclosed
Undisclosed
Undisclosed
[242]
AU2020291014A1 IC-45
undisclosed
Undisclosed
Undisclosed
[242]
AU2020291014A1 IC-50
undisclosed
Undisclosed
Undisclosed
[242]
AU2020291014A1 IC-52
undisclosed
Undisclosed
Undisclosed
[242]
AU2020291014A1 IC-53
undisclosed
Undisclosed
Undisclosed
[242]
AU2020291014A1 IC-54
undisclosed
Undisclosed
Undisclosed
[242]
AU2020291014A1 IC-55
undisclosed
Undisclosed
Undisclosed
[242]
AU2020291014A1 IC-56
undisclosed
Undisclosed
Undisclosed
[242]
AU2020291014A1 IC-59
undisclosed
Undisclosed
Undisclosed
[242]
AU2020291014A1 IC-60
undisclosed
Undisclosed
Undisclosed
[242]
AU2020291014A1 IC-61
undisclosed
Undisclosed
Undisclosed
[242]
AU2020291014A1 IC-62
AU2020291014A1-Payload-69
Undisclosed
Aminobenzazepine-linker Formula II-69
[242]
AU2020291014A1 IC-65
AU2020291014A1-Payload-70
Undisclosed
Aminobenzazepine-linker Formula II-69
[242]
AU2020291014A1 IC-66
AU2020291014A1-Payload-72
Undisclosed
Aminobenzazepine-linker Formula II-72
[242]
AU2020291014A1 IC-70
undisclosed
Undisclosed
Undisclosed
[242]
AU2020291014A1 IC-71
undisclosed
Undisclosed
Undisclosed
[242]
AU2020291014A1 IC-74
undisclosed
Undisclosed
Undisclosed
[242]
AU2020291014A1 IC-75
AU2020291014A1-Payload-74
Undisclosed
Undisclosed
[242]
AU2020291014A1 IC-76
AU2020291014A1-Payload-77
Undisclosed
Aminobenzazepine-linker Formula II-72
[242]
AU2020291014A1 IC-77
AU2020291014A1-Payload-35
Undisclosed
Aminobenzazepine-linker Formula II-75
[242]
AU2020291014A1 IC-78
AU2020291014A1-Payload-78
Undisclosed
Aminobenzazepine-linker Formula II-69
[242]
AU2020291014A1 IC-79
AU2020291014A1-Payload-70
Undisclosed
Aminobenzazepine-linker Formula II-75
[242]
AU2020291014A1 IC-86
AU2020291014A1-Payload-80
Undisclosed
Aminobenzazepine-linker Formula II-80
[242]
AU2020291014A1 IC-87
AU2020291014A1-Payload-82
Undisclosed
Aminobenzazepine-linker Formula II-82
[242]
AU2020291014A1 IC-90
undisclosed
Undisclosed
Undisclosed
[242]
AU2020291014A1 IC-91
AU2020291014A1-Payload-85
Undisclosed
Aminobenzazepine-linker Formula II-75
[242]
AU2020291014A1 IC-92
AU2020291014A1-Payload-69
Undisclosed
Aminobenzazepine-linker Formula II-69
[242]
Tra-25-4
PBX-7014
DNA topoisomerase I (TOP1)
Mc-Gly-Gly-Phe-Gly
[243]
Tra-25-6
PBX-7016
DNA topoisomerase I (TOP1)
Mc-Gly-Gly-Phe-Gly
[243]
EP4494656A1 DM-II
DM-II Payload
Undisclosed
DM-II Linker
[245]
EP4494656A1 DM-III
DM-III Payload
Undisclosed
DM-III Linker
[245]
EP4494656A1 DM-IV
undisclosed
Undisclosed
Undisclosed
[245]
EP4494656A1 DM-V
undisclosed
Undisclosed
Undisclosed
[245]
DS-24
DS-24 Payload
Undisclosed
DS-24 Linker
[246]
DS-26
DS-24 Payload
Undisclosed
DS-26 Linker
[246]
WO2019126691A1 Conjugate No.5
Conjugate No.5 Payload
Undisclosed
Conjugate No.5 Linker
[247]
WO2019126691A1 Conjugate No.10
Conjugate No.10 Payload
Undisclosed
Conjugate No.5 Linker
[247]
WO2019126691A1 Conjugate No.20
Conjugate No.20 Payload
Undisclosed
Conjugate No.20 Linker
[247]
WO2019126691A1 Conjugate No.26
Conjugate No.26 Payload
Undisclosed
Conjugate No.26 Linker
[247]
WO2019126691A1 Conjugate No.31
Conjugate No.31 Payload
Undisclosed
Conjugate No.20 Linker
[247]
WO2019126691A1 Conjugate No.36
Conjugate No.26 Payload
Undisclosed
Conjugate No.36 Linker
[247]
WO2019126691A1 Conjugate No.38
Conjugate No.26 Payload
Undisclosed
Conjugate No.38 Linker
[247]
WO2019126691A1 Conjugate No.46
Conjugate No.46 Payload
Undisclosed
Conjugate No.46 Linker
[247]
WO2019126691A1 Conjugate No.57
Conjugate No.57 Payload
Undisclosed
Conjugate No.57 Linker
[247]
WO2019126691A1 Conjugate No.60
Conjugate No.60 Payload
Undisclosed
Conjugate No.5 Linker
[247]
WO2019126691A1 Conjugate No.67
Conjugate No.67 Payload
Undisclosed
Conjugate No.67 Linker
[247]
WO2019126691A1 Conjugate No.71
Conjugate No.57 Payload
Undisclosed
Conjugate No.71 Linker
[247]
WO2019126691A1 Conjugate No.73
Conjugate No.67 Payload
Undisclosed
Conjugate No.73 Linker
[247]
WO2019126691A1 Conjugate No.79
Conjugate No.57 Payload
Undisclosed
Conjugate No.79 Linker
[247]
WO2019126691A1 Conjugate No.86
Conjugate No.67 Payload
Undisclosed
DL18 linker
[247]
WO2019126691A1 Conjugate No.94
Conjugate No.94 Payload
Undisclosed
Conjugate No.94 Linker
[247]
WO2019126691A1 Conjugate No.105
Conjugate No.105 Payload
Undisclosed
Conjugate No.105 Linker
[247]
WO2019126691A1 Conjugate No.112
Conjugate No.112 Payload
Undisclosed
Conjugate No.112 Linker
[247]
WO2019126691A1 Conjugate No.115
Conjugate No.112 Payload
Undisclosed
Conjugate No.115 Linker
[247]
WO2019126691A1 Conjugate No.119
Conjugate No.94 Payload
Undisclosed
Conjugate No.119 Linker
[247]
WO2019126691A1 Conjugate No.122
Conjugate No.94 Payload
Undisclosed
Conjugate No.122 Linker
[247]
WO2019126691A1 Conjugate No.130
Conjugate No.130 Payload
Undisclosed
Conjugate No.105 Linker
[247]
WO2019126691A1 Conjugate No.137
Conjugate No.137 Payload
Undisclosed
Conjugate No.105 Linker
[247]
CN115429893A ADC1
CN115429893A ADC1 Payload
Undisclosed
CB07 linker
[248]
CN115429893A ADC2
CN115429893A ADC2 Payload
Undisclosed
CB07 linker
[248]
CN115429893A ADC3
CN115429893A ADC3 Payload
Undisclosed
Mc-Gly-Gly-Phe-Gly
[248]
Trastuzumab-C-7
Undisclosed
Undisclosed
KR1020250002133A Trastuzumab-C-7 Linker
[249]
Trastuzumab-C-8
KR1020250002133A Trastuzumab-C-8 Payload
Undisclosed
KR1020250002133A Trastuzumab-C-8 Linker
[249]
Trastuzumab-C-9
Undisclosed
Undisclosed
KR1020250002133A Trastuzumab-C-9 Linker
[249]
Trastuzumab-C-10
undisclosed
Undisclosed
KR1020250002133A Trastuzumab-C-10 Linker
[249]
Trastuzumab-C-11
undisclosed
Undisclosed
KR1020250002133A Trastuzumab-C-11 Linker
[249]
Trastuzumab-C-15
undisclosed
Undisclosed
KR1020250002133A Trastuzumab-C-15 Linker
[249]
Trastuzumab-C-16
undisclosed
Undisclosed
KR1020250002133A Trastuzumab-C-16 Linker
[249]
Trastuzumab-C-17
undisclosed
Undisclosed
KR1020250002133A Trastuzumab-C-117 Linker
[249]
Trastuzumab-C-20
undisclosed
Undisclosed
KR1020250002133A Trastuzumab-C-20 Linker
[249]
Trastuzumab-C-21
undisclosed
Undisclosed
KR1020250002133A Trastuzumab-C-21 Linker
[249]
Trastuzumab-C-22
WO2023221971A1 NEC49-4 Payload
Undisclosed
KR1020250002133A Trastuzumab-C-22 Linker
[249]
HK40112172A Antibody-drug conjugate (2)
HK40112172A+Antibody-drug conjugate (2)+payload
Undisclosed
HK40112172A+Antibody-drug conjugate (2)+Linker
[250]
HK40112172A Antibody-drug conjugate (3)
HK40112172A+Antibody-drug conjugate (3)+payload
Undisclosed
Mc-Gly-Gly-Phe-Gly
[250]
HK40112172A Antibody-drug conjugate (4)
HK40112172A+Antibody-drug conjugate (4)+payload
Undisclosed
HK40112172A+Antibody-drug conjugate (4)+Linker
[250]
HK40112172A Antibody-drug conjugate (5)
LT4212552T ADC10 payload
DNA topoisomerase I (TOP1)
HK40112172A+Antibody-drug conjugate (4)+Linker
[250]
HK40112172A Antibody-drug conjugate (6)
LT4212552T ADC10 payload
DNA topoisomerase I (TOP1)
HK40112172A+Antibody-drug conjugate (6)+Linker
[250]
HK40112172A Antibody-drug conjugate (7)
LT4212552T ADC10 payload
DNA topoisomerase I (TOP1)
HK40112172A+Antibody-drug conjugate (7)+Linker
[250]
HK40112172A Antibody-drug conjugate (8)
LT4212552T ADC10 payload
DNA topoisomerase I (TOP1)
HK40112172A+Antibody-drug conjugate (7)+Linker
[250]
HK40112172A Antibody-drug conjugate (9)
LT4212552T ADC10 payload
DNA topoisomerase I (TOP1)
HK40112172A+Antibody-drug conjugate (7)+Linker
[250]
HK40112172A Antibody-drug conjugate (10)
LT4212552T ADC10 payload
DNA topoisomerase I (TOP1)
HK40112172A+Antibody-drug conjugate (7)+Linker
[250]
HK40112172A Antibody-drug conjugate (12)
LT4212552T ADC13 payload
DNA topoisomerase I (TOP1)
Mc-Gly-Gly-Phe-Gly
[250]
HK40112172A Antibody-drug conjugate (13)
LT4212552T ADC13 payload
DNA topoisomerase I (TOP1)
Mc-Gly-Gly-Phe-Gly
[250]
HK40112172A Antibody-drug conjugate (15)
LT4212552T ADC13 payload
DNA topoisomerase I (TOP1)
Mc-Gly-Gly-Phe-Gly
[250]
HK40112172A Antibody-drug conjugate (16)
LT4212552T ADC13 payload
DNA topoisomerase I (TOP1)
Mc-Gly-Gly-Phe-Gly
[250]
HK40112172A Antibody-drug conjugate (17)
HK40112172A+Antibody-drug conjugate (17)+payload
Undisclosed
HK40112172A+Antibody-drug conjugate (17)+Linker
[250]
HK40112172A Antibody-drug conjugate (18)
HK40112172A+Antibody-drug conjugate (17)+payload
Undisclosed
HK40112172A+Antibody-drug conjugate (17)+Linker
[250]
HK40112172A Antibody-drug conjugate (19)
HK40112172A+Antibody-drug conjugate (17)+payload
Undisclosed
HK40112172A+Antibody-drug conjugate (17)+Linker
[250]
HK40112172A Antibody-drug conjugate (20)
HK40112172A+Antibody-drug conjugate (17)+payload
Undisclosed
HK40112172A+Antibody-drug conjugate (17)+Linker
[250]
HK40112172A Antibody-drug conjugate (21)
LT4212552T ADC10 payload
DNA topoisomerase I (TOP1)
HK40112172A+Antibody-drug conjugate (7)+Linker
[250]
HK40112172A Antibody-drug conjugate (22)
LT4212552T ADC10 payload
DNA topoisomerase I (TOP1)
HK40112172A+Antibody-drug conjugate (7)+Linker
[250]
HK40112172A Antibody-drug conjugate (24)
LT4212552T ADC25 payload
DNA topoisomerase I (TOP1)
Mc-Gly-Gly-Phe-Gly
[250]
HK40112172A Antibody-drug conjugate (25)
LT4212552T ADC25 payload
DNA topoisomerase I (TOP1)
Mc-Gly-Gly-Phe-Gly
[250]
HK40112172A Antibody-drug conjugate (26)
LT4212552T ADC49 payload
DNA topoisomerase I (TOP1)
Mc-Gly-Gly-Phe-Gly
[250]
HK40112172A Antibody-drug conjugate (27)
LT4212552T ADC49 payload
DNA topoisomerase I (TOP1)
Mc-Gly-Gly-Phe-Gly
[250]
HK40112172A Antibody-drug conjugate (28)
LT4212552T ADC49 payload
DNA topoisomerase I (TOP1)
Mc-Gly-Gly-Phe-Gly
[250]
HK40112172A Antibody-drug conjugate (29)
LT4212552T ADC49 payload
DNA topoisomerase I (TOP1)
Mc-Gly-Gly-Phe-Gly
[250]
HK40112172A Antibody-drug conjugate (30)
LT4212552T ADC49 payload
DNA topoisomerase I (TOP1)
Mc-Gly-Gly-Phe-Gly
[250]
HK40112172A Antibody-drug conjugate (31)
LT4212552T ADC49 payload
DNA topoisomerase I (TOP1)
Mc-Gly-Gly-Phe-Gly
[250]
HK40112172A Antibody-drug conjugate (36)
LT4212552T ADC49 payload
DNA topoisomerase I (TOP1)
SCHEMBL17022441
[250]
HK40112172A Antibody-drug conjugate (37)
LT4212552T ADC37 payload
DNA topoisomerase I (TOP1)
SCHEMBL17022441
[250]
HK40112172A Antibody-drug conjugate (39)
HK40112172A+Antibody-drug conjugate (39)+payload
Undisclosed
HK40112172A+Antibody-drug conjugate (39)+Linker
[250]
HK40112172A Antibody-drug conjugate (40)
HK40112172A+Antibody-drug conjugate (39)+payload
Undisclosed
HK40112172A+Antibody-drug conjugate (39)+Linker
[250]
HK40112172A Antibody-drug conjugate (41)
Topo1 inhibitor B
DNA topoisomerase I (TOP1)
Mc-Gly-Gly-Phe-Gly
[250]
HK40112172A Antibody-drug conjugate (42)
Topo1 inhibitor B
DNA topoisomerase I (TOP1)
Mc-Gly-Gly-Phe-Gly
[250]
HK40112172A Antibody-drug conjugate (43)
LT4212552T ADC49 payload
DNA topoisomerase I (TOP1)
HK40112172A+Antibody-drug conjugate (43)+Linker
[250]
HK40112172A Antibody-drug conjugate (44)
LT4212552T ADC49 payload
DNA topoisomerase I (TOP1)
HK40112172A+Antibody-drug conjugate (44)+Linker
[250]
HK40112172A Antibody-drug conjugate (46)
LT4212552T ADC49 payload
DNA topoisomerase I (TOP1)
Mc-Gly-Gly-Phe-Gly
[250]
HK40112172A Antibody-drug conjugate (47)
LT4212552T ADC49 payload
DNA topoisomerase I (TOP1)
Mc-Gly-Gly-Phe-Gly
[250]
HK40112172A Antibody-drug conjugate (48)
LT4212552T ADC49 payload
DNA topoisomerase I (TOP1)
Mc-Gly-Gly-Phe-Gly
[250]
HK40112172A Antibody-drug conjugate (49)
LT4212552T ADC49 payload
DNA topoisomerase I (TOP1)
Mc-Gly-Gly-Phe-Gly
[250]
HK40112172A Antibody-drug conjugate (50)
Undisclosed
Undisclosed
Undisclosed
[250]
US20250018051A1 IaⅠ
US20250018038A1+IaⅠ+payload
Undisclosed
Mc-Val-Cit-PABC
[181]
US20250018051A1 IaⅡ
US20250018038A1+IaⅠ+payload
Undisclosed
TW202436324A+ADC-2+Linker
[181]
US20250018051A1 IaⅢ
US20250018038A1+IaⅢ+payload
Undisclosed
Mc-Val-Cit-PABC
[181]
US20250018051A1 IaⅣ
US20250018038A1+IaⅣ+payload
Undisclosed
Mc-Val-Ala-PABC
[181]
US20250018051A1 IaⅥ
US20250018038A1+IaⅥ+payload
Undisclosed
Mc-Val-Cit-PABC
[181]
US20250018051A1 IaⅧ
US20250018038A1+IaⅦ+payload
Undisclosed
TW202436324A+ADC-2+Linker
[181]
US20250018051A1 IaⅩ
US20250018038A1+IaⅢ+payload
Undisclosed
Mc-Val-Cit-PABC
[181]
US20250018051A1 Iaⅰ
US20250018038A1+IaⅣ+payload
Undisclosed
Mc-Val-Ala-PABC
[181]
US20250018051A1 IaⅰⅠ
US20250018038A1+IaⅥ+payload
Undisclosed
Mc-Val-Cit-PABC
[181]
US20250018051A1 IaⅰⅡ
US20250018038A1+IaⅦ+payload
Undisclosed
Mc-Val-Ala-PABC
[181]
US20250018051A1 IaⅰⅢ
US20250018038A1+IaⅣ+payload
Undisclosed
Mc-Val-Cit-PABC
[181]
US20250018051A1 IaⅰⅣ
US20250018038A1+IaⅰⅣ+payload
Undisclosed
Mc-Val-Ala-PABC
[181]
US20250018051A1 IaⅰⅥ
US20250018038A1+IaⅣ+payload
Undisclosed
Mc-Val-Cit-PABC
[181]
US20250018051A1 IaⅰⅦ
US20250018038A1+IaⅣ+payload
Undisclosed
Mc-Val-Ala-PABC
[181]
US11903948B2 I-1
Dolicatatin 5
Microtubule (MT)
Undisclosed
[251]
US11903948B2 I-2
Undisclosed
Undisclosed
Undisclosed
[251]
US11903948B2 I-3
Undisclosed
Undisclosed
Undisclosed
[251]
HER-E-36
WO2024020536A1+HER-E-36+payload
Undisclosed
WO2024020536A1+HER-E-36+Linker
[252]
HER-E-37
WO2024020536A1+HER-E-37+payload
Undisclosed
Mc-Gly-Gly-Phe-Gly
[252]
HER-E-39
WO2024020536A1+HER-E-37+payload
Undisclosed
Mc-Gly-Gly-Phe-Gly
[252]
HER-E-40
WO2024020536A1+HER-E-37+payload
Undisclosed
Mc-Gly-Gly-Phe-Gly
[252]
HER-E-44
WO2024020536A1+HER-E-44+payload
Undisclosed
WO2024020536A1+HER-E-44+Linker
[252]
HER-E-46
WO2024020536A1+HER-E-44+payload
Undisclosed
Mc-Gly-Gly-Phe-Gly
[252]
HER-E-48
WO2024020536A1+HER-E-48+payload
Undisclosed
WO2024020536A1+HER-E-48+Linker
[252]
HER-E-49
WO2024020536A1+HER-E-37+payload
Undisclosed
WO2024020536A1+HER-E-49+Linker
[252]
Trastuzumab-DXD (EP4183421A1)
Exatecan
DNA topoisomerase 1 (TOP1)
EP4183421A1+Trastuzumab-DXD+Linker
[253]
Trastuzumab-DDDXD
Exatecan
DNA topoisomerase 1 (TOP1)
EP4183421A1+Trastuzumab-DDDXD+Linker
[253]
JP2025004232A ADC9
undisclosed
Undisclosed
Undisclosed
[254]
EP4227309A4 ADC-1
undisclosed
Undisclosed
Undisclosed
[255]
EP4227309A4 ADC-2
undisclosed
Undisclosed
Undisclosed
[255]
EP4227309A4 ADC-3
undisclosed
Undisclosed
Undisclosed
[255]
EP4227309A4 ADC-4
undisclosed
Undisclosed
Undisclosed
[255]
EP4227309A4 ADC-5
undisclosed
Undisclosed
Undisclosed
[255]
EP4227309A4 ADC-6
undisclosed
Undisclosed
Undisclosed
[255]
EP4227309A4 ADC-7
undisclosed
Undisclosed
Undisclosed
[255]
EP4227309A4 ADC-8
undisclosed
Undisclosed
Undisclosed
[255]
EP4227309A4 ADC-9
undisclosed
Undisclosed
Undisclosed
[255]
EP4227309A4 ADC-10
undisclosed
Undisclosed
Undisclosed
[255]
EP4227309A4 ADC-11
undisclosed
Undisclosed
Undisclosed
[255]
EP4227309A4 ADC-12
undisclosed
Undisclosed
Undisclosed
[255]
EP4227309A4 ADC-13
undisclosed
Undisclosed
Undisclosed
[255]
EP4227309A4 ADC-14
undisclosed
Undisclosed
Undisclosed
[255]
EP4227309A4 ADC-15
undisclosed
Undisclosed
Undisclosed
[255]
EP4227309A4 ADC-16
undisclosed
Undisclosed
Undisclosed
[255]
EP4227309A4 ADC-17
undisclosed
Undisclosed
Undisclosed
[255]
EP4227309A4 ADC-18
undisclosed
Undisclosed
Undisclosed
[255]
US11850287B2 IIIa
Undisclosed
Undisclosed
Undisclosed
[257]
US11850287B2 IIIb
Undisclosed
Undisclosed
Undisclosed
[257]
US11850287B2 IIIc
Undisclosed
Undisclosed
Undisclosed
[257]
US11850287B2 IIId
Undisclosed
Undisclosed
Undisclosed
[257]
WO2023232144A1ADC-6
WO2023232144A1, ADC-2, Payload
DNA topoisomerase I (TOP1)
WO2023232144A1, ADC-2, linker
[15]
WO2023232144A1ADC22
WO2025015586A1, ADC22, Payload
DNA topoisomerase I (TOP1)
Mc-Val-Cit-PABC
[81]
WO2023232144A1ADC23
WO2025015586A1, ADC23, Payload
Toll-like receptor 7 (TLR7); Toll-like receptor 8 (TLR8)
Mc-Val-Cit-PABC
[81]
WO2023232144A1ADC24
WO2025015586A1, ADC24, Payload
Toll-like receptor 7 (TLR7); Toll-like receptor 8 (TLR8)
Mc-Val-Cit-PABC
[81]
WO2023232144A1ADC25
WO2025015586A1, ADC25, Payload
Toll-like receptor 7 (TLR7); Toll-like receptor 8 (TLR8)
Mc-Val-Cit-PABC
[81]
WO2023232144A1ADC30
WO2025015586A1, ADC25, Payload
Toll-like receptor 7 (TLR7); Toll-like receptor 8 (TLR8)
SMCC
[81]
WO2023232144A1ADC32
WO2025015586A1, ADC22, Payload
DNA topoisomerase I (TOP1)
SMCC
[81]
AU2023308528A1 ADC3
Exatecan
DNA topoisomerase 1 (TOP1)
Mal-amido-PEG8-acid
[258]
AU2023308528A1 ADC5
4- ((S)-2- ((S)-2-amino-3-methylbutanamido)propanamido)benzyl ((1S,9S)-9-ethyl-5-fluoro-9-hydroxy-4-methyl-10,13-dioxo-2,3,9,10,13,15-hexahydro-1H,12H-benzo[de]pyrano[3',4':6,7]indolizino[1,2-b]quinolin-1-yl)carbamate
DNA topoisomerase I (TOP1)
Mal-amido-PEG8-acid
[258]
AU2023308528A1 ADC1
PBD aromatic-amide derivative
DNA topoisomerase I (TOP1)
6-Maleimidocaproic acid
[258]
AU2023308528A1 ADC2
PBD-butanamide derivative
DNA topoisomerase I (TOP1)
6-Maleimidocaproic acid
[258]
AU2023308528A1 ADC7
N- (4- ((S)-2- ((S)-2-amino-3- methylbutanamido)propanamido)phenyl)-4- (4- (4- (4- (( (S)-2-methoxy-12-oxo-6a,7,8,9,10,12-hexahydrobenzo[e]pyrido[1,2-a][1,4]diazepin-3-yl)oxy)butanamido)-1-methyl-1H-pyrrole-2-carboxamido)phenyl)-1-methyl-1H-pyrrole-2-carboxamide
DNA topoisomerase I (TOP1)
(S)-75-oxo-76- (4- (3-tosyl-2- (tosylmethyl)propanoyl)benzamido) 2,5,8,11,14,17,20,23,26,29,32,35,38,41,44,47,50,53,56,59,62,65,68,71-tetracosaoxa-74 azanonaheptacontan-79-oic acid
[258]
AU2023308528A1 ADC2 (DAR of 4)
PBD-butanamide derivative
DNA topoisomerase I (TOP1)
6-Maleimidocaproic acid
[258]
Trastuzumab-Compound 30
Exatecan
DNA topoisomerase 1 (TOP1)
Mal-amido-PEG8-acid
[258]
AU2023279443A1 Example 1
U-030; Ac-Exatecan
Undisclosed
AU2023279443A1, Example 1, Linker
[259]
AU2023279443A1 Example 2
U-031
Microtubule (MT)
AU2023279443A1, Example 3, Linker
[259]
AU2023279443A1 Example 3
U-030
DNA topoisomerase I (TOP1)
AU2023279443A1, Example 4, Linker
[259]
AU2023279443A1 Example 4
U-031
Microtubule (MT)
AU2023279443A1, Example 4, Linker
[259]
AU2023279443A1 Example 5
U-031
Microtubule (MT)
AU2023279443A1, Example 5, Linker
[259]
AU2023279443A1 Example 6
U-031; AU2023279443A1, Example 6, Paylaod
Undisclosed
AU2023279443A1, Example 4, Linker
[259]
AU2023279443A1 Example 7
U-031; U-033
Undisclosed
AU2023279443A1, Example 4, Linker
[259]
AU2023279443A1 Example A1
Monomethyl auristatin E
Microtubule (MT)
Undisclosed
[259]
AU2023279443A1 Example A2
U-030
DNA topoisomerase I (TOP1)
Undisclosed
[259]
AU2023279443A1 Example A3
U-031
Microtubule (MT)
AU2023279443A1, Example A3, Linker
[259]
AU2023279443A1 Example A4
U-003
Microtubule (MT)
Undisclosed
[259]
AU2023279443A1 Example A5
U-029
Microtubule (MT)
Undisclosed
[259]
AU2023279443A1 Example A6
Monomethyl auristatin E
Microtubule (MT)
AU2023279443A1, Example A6, Linker
[259]
AU2023279443A1 Example A7
Monomethyl auristatin E
Microtubule (MT)
AU2023279443A1, Example A7, Linker
[259]
AU2023279443A1 Example A8
Monomethyl auristatin E
Microtubule (MT)
RU20241285-9-linker
[259]
AU2023279443A1 Example A9
U-036
Microtubule (MT)
RU20241285-9-linker
[259]
AU2023279443A1 Example A10
Ac-Exatecan
DNA topoisomerase I (TOP1)
AU2023279443A1, Example A10, Linker
[259]
AU2023279443A1 Example A11
DX-8951 derivative (DXd)
DNA topoisomerase 1 (TOP1)
AU2023279443A1, Example A10, Linker
[259]
AU2023279443A1 Example A12
U-035
Microtubule (MT)
AU2023279443A1, Example A12, Linker
[259]
AU2023279443A1 Example A13
DX-8951 derivative (DXd)
DNA topoisomerase 1 (TOP1)
AU2023279443A1, Example A13, Linker
[259]
AU2023279443A1 Example A14
Eribulin
Microtubule (MT)
RU20241285-9-linker
[259]
AU2023279443A1Example A15
U-031
Microtubule (MT)
AU2023279443A1, Example A15, Linker
[259]
AU2023279443A1 Example A16
Eribulin
Microtubule (MT)
AU2023279443A1, Example A16, Linker
[259]
AU2023279443A1 Example A17
Eribulin
Microtubule (MT)
AU2023279443A1, Example A17, Linker
[259]
AU2023279443A1 Example A18
Eribulin
Microtubule (MT)
AU2023279443A1, Example A18, Linker
[259]
AU2023279443A1 Example A19
U-031
Microtubule (MT)
AU2023279443A1, Example A19, Linker
[259]
AU2023279443A1 Example A20
Topo1 inhibitor A
DNA topoisomerase I (TOP1)
AU2023279443A1, Example A12, Linker
[259]
AU2023279443A1 Example A21
Eribulin
Microtubule (MT)
AU2023279443A1, Example A21, Linker
[259]
AU2023279443A1 Example A22
Eribulin
Microtubule (MT)
AU2023279443A1, Example A22, Linker
[259]
AU2023279443A1 Example A23
RU20241285-23-payload
DNA topoisomerase I (TOP1)
AU2023279443A1, Example A10, Linker
[259]
AU2023279443A1 Example A24
RU20241285-23-payload
DNA topoisomerase I (TOP1)
AU2023279443A1, Example A24, Linker
[259]
AU2023279443A1 Comparative Control Compound-1
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
[259]
AU2023279443A1 Comparative Control Compound-2
Eribulin
Microtubule (MT)
Mal-PEG2-Val-Cit-PAB
[259]
CN113943310A ADC-1
D-D9 payload
DNA topoisomerase I (TOP1)
CN113943310A, ADC-1, Linker
[260]
CN113943310A ADC-2
D-D10 payload
DNA topoisomerase I (TOP1)
CN113943310A, ADC-1, Linker
[260]
CN113943310A ADC-3
D-D3 payload
DNA topoisomerase I (TOP1)
CN113943310A, ADC-1, Linker
[260]
CN113943310A ADC-4
D-D4 payload
DNA topoisomerase I (TOP1)
CN113943310A, ADC-1, Linker
[260]
CN113943310A ADC-5
D-D5 payload
DNA topoisomerase I (TOP1)
CN113943310A, ADC-1, Linker
[260]
CN113943310A ADC-6
D-D6 payload
DNA topoisomerase I (TOP1)
CN113943310A, ADC-1, Linker
[260]
CN113943310A ADC-7
D-D11 payload
DNA topoisomerase I (TOP1)
CN113943310A, ADC-1, Linker
[260]
CN113943310A ADC-8
D-D12 payload
DNA topoisomerase I (TOP1)
CN113943310A, ADC-1, Linker
[260]
CN113943310A ADC-9
D-D14 payload
DNA topoisomerase I (TOP1)
CN113943310A, ADC-1, Linker
[260]
CN113943310A ADC-10
D-D1 payload
DNA topoisomerase I (TOP1)
CN113943310A, ADC-1, Linker
[260]
CN113943310A ADC-11
WO2025015586A1, ADC25, Payload
Toll-like receptor 7 (TLR7); Toll-like receptor 8 (TLR8)
Mc-Gly-Gly-Phe-Gly
[260]
CN113943310A ADC-12
WO2025015586A1, ADC25, Payload
Toll-like receptor 7 (TLR7); Toll-like receptor 8 (TLR8)
CN113943310A, ADC-12, Linker
[260]
CN113943310A ADC-13
WO2025015586A1, ADC23, Payload
Toll-like receptor 7 (TLR7); Toll-like receptor 8 (TLR8)
CN113943310A, ADC-12, Linker
[260]
CN113943310A ADC-14
compound 4
DNA topoisomerase I (TOP1)
CN113943310A, ADC-12, Linker
[260]
CN113943310A ADC-15
compound 5
DNA topoisomerase I (TOP1)
CN113943310A, ADC-12, Linker
[260]
CN113943310A ADC-16
WO2025015586A1, ADC24, Payload
Toll-like receptor 7 (TLR7); Toll-like receptor 8 (TLR8)
CN113943310A, ADC-12, Linker
[260]
CN113943310A ADC-17
WO2025015586A1, ADC35, Payload
Toll-like receptor 7 (TLR7); Toll-like receptor 8 (TLR8)
CN113943310A, ADC-12, Linker
[260]
CN113943310A ADC-18
WO2025015586A1, ADC34, Payload
Toll-like receptor 7 (TLR7); Toll-like receptor 8 (TLR8)
CN113943310A, ADC-12, Linker
[260]
CN106714844B ADC-141
Mertansine DM1
Microtubule (MT)
Succinimidyl-4- (N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
[3]
Tras-1
US11141490B2-Tras-1-payload
Undisclosed
US11141490B2-Tras-1-linker
[261]
Tras-4
US11141490B2-Tras-4-payload
Undisclosed
Ethylmaleimide linker
[261]
CN110974975B C-01
Exatecan
DNA topoisomerase 1 (TOP1)
Coumpound7
[262]
CN110974975B C-06
Exatecan
DNA topoisomerase 1 (TOP1)
Coumpound15
[262]
CN110974975B C-07
Active metabolite of irinotecan SN38
DNA topoisomerase 1 (TOP1)
Coumpound17
[262]
CN110974975B C-00
Monomethyl auristatin E
Microtubule (MT)
CN110974975B-C-00-linker
[262]
CN116888123A ADC-1
D2 payload
Undisclosed
Mc-Gly-Gly-Phe-Gly
[263]
CN116888123A ADC-2
D2 payload
Undisclosed
LA2 linker
[263]
CN116888123A ADC-3
D2 payload
Undisclosed
LA2 linker
[263]
CN116888123A ADC-4
D3 payload
Undisclosed
Mc-Gly-Gly-Phe-Gly
[263]
CN116888123A ADC-5
D1 payload
Undisclosed
B1-b linker
[263]
CN116888123A ADC-6
D1-SH payload
Undisclosed
LC1 linker
[263]
CN116888123A ADC-7
D2 payload
Undisclosed
LD1 linker
[263]
BCN-linker-Dxd1
DX-8951 derivative (DXd)
DNA topoisomerase 1 (TOP1)
BCN-linker
[264]
BCN-linker-Dxd2
DX-8951 derivative (DXd)
DNA topoisomerase 1 (TOP1)
BCN-linker
[264]
BCN-linker-Dxd3
DX-8951 derivative (DXd)
DNA topoisomerase 1 (TOP1)
BCN-linker
[264]
BCN-linker-Dxd4
DX-8951 derivative (DXd)
DNA topoisomerase 1 (TOP1)
BCN-linker
[264]
SMCC-calicheamicin-ADC
Calicheamicin
Undisclosed
Succinimidyl-4- (N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
[265]
SMPB-calicheamicin-ADC
Calicheamicin
Undisclosed
Undisclosed
[265]
AU2016292759A1 ADC-1
AU2016292759A1-ADC-1-payload
Undisclosed
AU2016292759A1-ADC-1-linker
[266]
TrastuzumabA132TCO*A
Undisclosed
Undisclosed
CN118574641A-TrastuzumabA132TCO*A-linker
[267]
Trastuzumab-TCO*A-5
Undisclosed
Undisclosed
CN118574641A-Trastuzumab-TCO*A-5-linker
[267]
Trastuzumab-TCO*A-11
Undisclosed
Undisclosed
CN118574641A-Trastuzumab-TCO*A-11-linker
[267]
US20240148889A1 ADC-1
US20240148889A1-ADC-1-payload
Undisclosed
US20240148889A1-ADC-1-linker
[268]
TWI870307BAntibody-drug conjugate (2)
LT4212552T ADC10 payload
DNA topoisomerase I (TOP1)
Mc-Gly-Gly-Phe-Gly
[269]
TWI870307BAntibody-drug conjugate (3)
LT4212552T ADC10 payload
DNA topoisomerase I (TOP1)
Mc-Gly-Gly-Phe-Gly
[269]
TWI870307BAntibody-drug conjugate (4)
LT4212552T ADC10 payload
DNA topoisomerase I (TOP1)
TWI870307BAntibody-drug conjugate (4)Linker
[269]
TWI870307BAntibody-drug conjugate (5)
LT4212552T ADC10 payload
DNA topoisomerase I (TOP1)
TWI870307BAntibody-drug conjugate (4)Linker
[269]
TWI870307BAntibody-drug conjugate (6)
LT4212552T ADC10 payload
DNA topoisomerase I (TOP1)
TWI870307BAntibody-drug conjugate (6)Linker
[269]
TWI870307BAntibody-drug conjugate (7)
LT4212552T ADC10 payload
DNA topoisomerase I (TOP1)
TWI870307BAntibody-drug conjugate (6)Linker
[269]
TWI870307BAntibody-drug conjugate (8)
LT4212552T ADC10 payload
DNA topoisomerase I (TOP1)
TWI870307BAntibody-drug conjugate (6)Linker
[269]
TWI870307BAntibody-drug conjugate (9)
LT4212552T ADC10 payload
DNA topoisomerase I (TOP1)
TWI870307BAntibody-drug conjugate (9)Linker
[269]
TWI870307BAntibody-drug conjugate (10)
LT4212552T ADC10 payload
DNA topoisomerase I (TOP1)
TWI870307BAntibody-drug conjugate (9)Linker
[269]
TWI870307BAntibody-drug conjugate (12)
TWI870307BAntibody-drug conjugate (12)Payload
Undisclosed
Mc-Gly-Gly-Phe-Gly
[269]
TWI870307BAntibody-drug conjugate (13)
TWI870307BAntibody-drug conjugate (12)Payload
Undisclosed
Mc-Gly-Gly-Phe-Gly
[269]
TWI870307BAntibody-drug conjugate (15)
TWI870307BAntibody-drug conjugate (12)Payload
Undisclosed
Mc-Gly-Gly-Phe-Gly
[269]
TWI870307BAntibody-drug conjugate (16)
TWI870307BAntibody-drug conjugate (12)Payload
Undisclosed
Mc-Gly-Gly-Phe-Gly
[269]
TWI870307BAntibody-drug conjugate (17)
TWI870307BAntibody-drug conjugate (12)Payload
Undisclosed
LT4212552T-ADC-5-LINKER
[269]
TWI870307BAntibody-drug conjugate (18)
TWI870307BAntibody-drug conjugate (12)Payload
Undisclosed
LT4212552T-ADC-5-LINKER
[269]
TWI870307BAntibody-drug conjugate (19)
TWI870307BAntibody-drug conjugate (12)Payload
Undisclosed
HK40112172A+Antibody-drug conjugate (19)+Linker
[269]
TWI870307BAntibody-drug conjugate (20)
TWI870307BAntibody-drug conjugate (12)Payload
Undisclosed
HK40112172A+Antibody-drug conjugate (19)+Linker
[269]
TWI870307BAntibody-drug conjugate (21)
TWI870307BAntibody-drug conjugate (12)Payload
Undisclosed
TWI870307BAntibody-drug conjugate (21)Linker
[269]
TWI870307BAntibody-drug conjugate (22)
TWI870307BAntibody-drug conjugate (12)Payload
Undisclosed
TWI870307BAntibody-drug conjugate (21)Linker
[269]
TWI870307BAntibody-drug conjugate (24)
LT4212552T ADC25 payload
DNA topoisomerase I (TOP1)
Mc-Gly-Gly-Phe-Gly
[269]
TWI870307BAntibody-drug conjugate (25)
LT4212552T ADC25 payload
DNA topoisomerase I (TOP1)
Mc-Gly-Gly-Phe-Gly
[269]
TWI870307BAntibody-drug conjugate (26)
TWI870307BAntibody-drug conjugate (26)Payload
Undisclosed
TWI870307BAntibody-drug conjugate (26)Linker
[269]
TWI870307BAntibody-drug conjugate (27)
TWI870307BAntibody-drug conjugate (26)Payload
Undisclosed
TWI870307BAntibody-drug conjugate (26)Linker
[269]
TWI870307BAntibody-drug conjugate (28)
TWI870307BAntibody-drug conjugate (26)Payload
Undisclosed
TWI870307BAntibody-drug conjugate (26)Linker
[269]
TWI870307BAntibody-drug conjugate (29)
TWI870307BAntibody-drug conjugate (26)Payload
Undisclosed
TWI870307BAntibody-drug conjugate (26)Linker
[269]
TWI870307BAntibody-drug conjugate (30)
TWI870307BAntibody-drug conjugate (26)Payload
Undisclosed
TWI870307BAntibody-drug conjugate (26)Linker
[269]
TWI870307BAntibody-drug conjugate (31)
TWI870307BAntibody-drug conjugate (26)Payload
Undisclosed
TWI870307BAntibody-drug conjugate (26)Linker
[269]
TWI870307BAntibody-drug conjugate (36)
LT4212552T ADC37 payload
DNA topoisomerase I (TOP1)
TWI870307BAntibody-drug conjugate (36)Linker
[269]
TWI870307BAntibody-drug conjugate (37)
LT4212552T ADC37 payload
DNA topoisomerase I (TOP1)
TWI870307BAntibody-drug conjugate (36)Linker
[269]
TWI870307BAntibody-drug conjugate (39)
TWI870307BAntibody-drug conjugate (39)Payload
Undisclosed
TWI870307BAntibody-drug conjugate (39)Linker
[269]
TWI870307BAntibody-drug conjugate (40)
TWI870307BAntibody-drug conjugate (39)Payload
Undisclosed
TWI870307BAntibody-drug conjugate (39)Linker
[269]
TWI870307BAntibody-drug conjugate (41)
Topo1 inhibitor B
DNA topoisomerase I (TOP1)
Mc-Gly-Gly-Phe-Gly
[269]
TWI870307BAntibody-drug conjugate (42)
Topo1 inhibitor B
DNA topoisomerase I (TOP1)
Mc-Gly-Gly-Phe-Gly
[269]
TWI870307BAntibody-drug conjugate (43)
LT4212552T ADC49 payload
DNA topoisomerase I (TOP1)
TWI870307BAntibody-drug conjugate (6)Linker
[269]
TWI870307BAntibody-drug conjugate (44)
TWI870307BAntibody-drug conjugate (44)Payload
Undisclosed
TWI870307BAntibody-drug conjugate (44)Linker
[269]
TWI870307BAntibody-drug conjugate (46)
Undisclosed
Undisclosed
Mc-Gly-Gly-Phe-Gly
[269]
TWI870307BAntibody-drug conjugate (47)
Undisclosed
Undisclosed
Mc-Gly-Gly-Phe-Gly
[269]
TWI870307BAntibody-drug conjugate (48)
Undisclosed
Undisclosed
Mc-Gly-Gly-Phe-Gly
[269]
TWI870307BAntibody-drug conjugate (49)
Undisclosed
Undisclosed
Mc-Gly-Gly-Phe-Gly
[269]
TWI870307BAntibody-drug conjugate (50)
Undisclosed
Undisclosed
Mc-Gly-Gly-Phe-Gly
[269]
KR102754055B1 ADCProductionexampleNo.1
ADCProductionexampleNo.1Payload
Undisclosed
Mc-Val-Cit-PABC
[89]
KR102754055B1 ADCProductionexampleNo.2
ADCProductionexampleNo.2Payload
Undisclosed
ADCProductionexampleNo.2Linker
[89]
KR102754055B1 ADCProductionexampleNo.3a
ADCProductionexampleNo.3aPayload
Undisclosed
ADCProductionexampleNo.3aLinker
[89]
KR102754055B1 ADCProductionexampleNo.3b
ADCProductionexampleNo.3bPayload
Undisclosed
ADCProductionexampleNo.3aLinker
[89]
KR102754055B1 ADCProductionexampleNo.3c
ADCProductionexampleNo.3cPayload
Undisclosed
ADCProductionexampleNo.3aLinker
[89]
KR102754055B1 ADCProductionexampleNo.4
ADCProductionexampleNo.4Payload
Undisclosed
ADCProductionexampleNo.4Linker
[89]
KR102754055B1 ADCProductionexampleNo.5
ADCProductionexampleNo.5Payload
Undisclosed
RU20241285-4-linker
[89]
KR102754055B1 ADCProductionexampleNo.6
ADCProductionexampleNo.6Payload
Undisclosed
ADCProductionexampleNo.6Linker
[89]
KR102754055B1 ADCProductionexampleNo.7
ADCProductionexampleNo.7Payload
Undisclosed
ADCProductionexampleNo.7Linker
[89]
KR102754055B1 ADCProductionexampleNo.8
ADCProductionexampleNo.8Payload
Undisclosed
ADCProductionexampleNo.8Linker
[89]
KR102754055B1 ADCProductionexampleNo.9
ADCProductionexampleNo.9Payload
Undisclosed
ADCProductionexampleNo.9Linker
[89]
KR102754055B1 ADCProductionexampleNo.10
ADCProductionexampleNo.10Payload
Undisclosed
ADCProductionexampleNo.10Linker
[89]
KR102754055B1 ADCProductionexampleNo.11
ADCProductionexampleNo.11Payload
Undisclosed
ADCProductionexampleNo.11Linker
[89]
KR102754055B1 ADCProductionexampleNo.12
ADCProductionexampleNo.12Payload
Undisclosed
ADCProductionexampleNo.8Linker
[89]
KR102754055B1 ADCProductionexampleNo.13
ADCProductionexampleNo.13Payload
Undisclosed
ADCProductionexampleNo.13Linker
[89]
KR102754055B1 ADCProductionexampleNo.14
Undisclosed
Undisclosed
ADCProductionexampleNo.15Linker
[89]
KR102754055B1 ADCProductionexampleNo.15
ADCProductionexampleNo.15Payload
Undisclosed
ADCProductionexampleNo.15Linker
[89]
KR102754055B1 ADCProductionexampleNo.16
ADCProductionexampleNo.16Payload
Undisclosed
ADCProductionexampleNo.16Linker
[89]
KR102754055B1 ADCProductionexampleNo.17
ADCProductionexampleNo.17Payload
Undisclosed
ADCProductionexampleNo.17Linker
[89]
KR102754055B1 ADCProductionexampleNo.18
ADCProductionexampleNo.18Payload
Undisclosed
ADCProductionexampleNo.18Linker
[89]
KR102754055B1 ADCProductionexampleNo.19
ADCProductionexampleNo.19Payload
Undisclosed
ADCProductionexampleNo.19Linker
[89]
KR102754055B1 ADCProductionexampleNo.20
ADCProductionexampleNo.20Payload
Undisclosed
ADCProductionexampleNo.20Linker
[89]
KR102754055B1 ADCProductionexampleNo.21
ADCProductionexampleNo.20Payload
Undisclosed
ADCProductionexampleNo.20Linker
[89]
KR102754055B1 ADCProductionexampleNo.22
ADCProductionexampleNo.20Payload
Undisclosed
ADCProductionexampleNo.20Linker
[89]
KR102754055B1 ADCProductionexampleNo.23
Undisclosed
Undisclosed
Undisclosed
[89]
KR102754055B1 ADCProductionexampleNo.24
Undisclosed
Undisclosed
Undisclosed
[89]
CH-2-589
Undisclosed
Undisclosed
Undisclosed
[89]
CH-2-593
Undisclosed
Undisclosed
Undisclosed
[270]
CH-2-518
Undisclosed
Undisclosed
Undisclosed
[270]
LC302-2-1
Undisclosed
Undisclosed
Undisclosed
[270]
LC302-2-4 (4) 3.41
Undisclosed
Undisclosed
Undisclosed
[270]
IN202417100055A Reference Example A1
Undisclosed
Undisclosed
Undisclosed
[271]
IN202417100055A Reference Example A2
Undisclosed
Undisclosed
Undisclosed
[271]
IN202417100055A Reference Example A3
Undisclosed
Undisclosed
Undisclosed
[271]
IN202417100055A Reference Example A3b
Undisclosed
Undisclosed
Undisclosed
[271]
IN202417100055A Reference Example A3c
Undisclosed
Undisclosed
Undisclosed
[271]
IN202417100055A Reference Example A4
Undisclosed
Undisclosed
Undisclosed
[271]
IN202417100055A Reference Example A5
Undisclosed
Undisclosed
Undisclosed
[271]
IN202417100055A Reference Example A6
Undisclosed
Undisclosed
Undisclosed
[271]
IN202417100055A Reference Example A7
Undisclosed
Undisclosed
Undisclosed
[271]
IN202417100055A Reference Example A8
Undisclosed
Undisclosed
Undisclosed
[271]
IN202417100055A Reference Example A9
Undisclosed
Undisclosed
Undisclosed
[271]
IN202417100055A Reference Example A10
Undisclosed
Undisclosed
Undisclosed
[271]
IN202417100055A Reference Example A11
Undisclosed
Undisclosed
Undisclosed
[271]
IN202417100055A Reference Example A12
Undisclosed
Undisclosed
Undisclosed
[271]
IN202417100055A Reference Example A13
Undisclosed
Undisclosed
Undisclosed
[271]
IN202417100055A Reference Example A14
Undisclosed
Undisclosed
Undisclosed
[271]
IN202417100055A Reference Example A15
Undisclosed
Undisclosed
Undisclosed
[271]
IN202417100055A Reference Example A16
Undisclosed
Undisclosed
Undisclosed
[271]
IN202417100055A Reference Example A17
Undisclosed
Undisclosed
Undisclosed
[271]
IN202417100055A Reference Example A18
Undisclosed
Undisclosed
Undisclosed
[271]
IN202417100055A Reference Example A19
Undisclosed
Undisclosed
Undisclosed
[271]
IN202417100055A Reference Example A20
Undisclosed
Undisclosed
Undisclosed
[271]
IN202417100055A Reference Example A21
Undisclosed
Undisclosed
Undisclosed
[271]
IN202417100055A Reference Example A22
Undisclosed
Undisclosed
Undisclosed
[271]
IN202417100055A Reference Example A23
Undisclosed
Undisclosed
Undisclosed
[271]
IN202417100055A Reference Example A24
Undisclosed
Undisclosed
Undisclosed
[271]
IN202417100055A Reference Example A25
Undisclosed
Undisclosed
Undisclosed
[271]
IN202417100055A Reference Example A26
Undisclosed
Undisclosed
Undisclosed
[271]
IN202417100055A Reference Example 1
Undisclosed
Undisclosed
Undisclosed
[271]
IN202417100055A Reference Example 2
Undisclosed
Undisclosed
Undisclosed
[271]
IN202417100055A Reference Example 3
Undisclosed
Undisclosed
Undisclosed
[271]
IN202417100055A Reference Example 4
Undisclosed
Undisclosed
Undisclosed
[271]
IN202417100055A Reference Example 5
Undisclosed
Undisclosed
Undisclosed
[271]
IN202417100055A Reference Example 6
Undisclosed
Undisclosed
Undisclosed
[271]
IN202417100055A Reference Example 7
Undisclosed
Undisclosed
Undisclosed
[272]
CN115594732A I-LD011
undisclosed
Undisclosed
Undisclosed
[273]
CN115594732A I-LD012
undisclosed
Undisclosed
Undisclosed
[273]
CN115594732A I-LD013
undisclosed
Undisclosed
Undisclosed
[273]
CN115594732A I-LD014
undisclosed
Undisclosed
Undisclosed
[273]
CN115594732A I-LD015
undisclosed
Undisclosed
Undisclosed
[273]
CN115594732A I-LD016
undisclosed
Undisclosed
Undisclosed
[273]
CN115594732A I-LD017
undisclosed
Undisclosed
Undisclosed
[273]
CN115594732A I-LD018A
undisclosed
Undisclosed
Undisclosed
[273]
CN115594732A I-LD018B
undisclosed
Undisclosed
Undisclosed
[273]
CN115594732A I-LD019
undisclosed
Undisclosed
Undisclosed
[273]
CN115594732A I-LD020
undisclosed
Undisclosed
Undisclosed
[273]
CN115594732A I-LD021
undisclosed
Undisclosed
Undisclosed
[273]
CN115594732A II-LD-011
undisclosed
Undisclosed
Undisclosed
[273]
CN115594732A II-LD-012
undisclosed
Undisclosed
Undisclosed
[273]
CN115594732A II-LD-013
undisclosed
Undisclosed
Undisclosed
[273]
CN115594732A II-LD-014
undisclosed
Undisclosed
Undisclosed
[273]
CN115594732A II-LD-015
undisclosed
Undisclosed
Undisclosed
[273]
CN115594732A II-LD-016
undisclosed
Undisclosed
Undisclosed
[273]
CN115594732A II-LD-017
undisclosed
Undisclosed
Undisclosed
[273]
CN115594732A II-LD-018
undisclosed
Undisclosed
Undisclosed
[273]
CN115594732A II-LD-019
undisclosed
Undisclosed
Undisclosed
[273]
CN118873678A ADC-1
undisclosed
Undisclosed
Undisclosed
[274]
CN118873678A ADC-2
Undisclosed
Undisclosed
Undisclosed
[274]
CN118873678A ADC-3
Undisclosed
Undisclosed
Undisclosed
[274]
CN118873678A ADC-4
undisclosed
Undisclosed
Undisclosed
[274]
CN118873678A ADC-5
Undisclosed
Undisclosed
Undisclosed
[274]
CN118873678A ADC-6
Undisclosed
Undisclosed
Undisclosed
[274]
CN118873678A ADC-7
Undisclosed
Undisclosed
Undisclosed
[274]
CN118873678A ADC-8
Undisclosed
Undisclosed
Undisclosed
[274]
CN118873678A ADC-9
Undisclosed
Undisclosed
Undisclosed
[274]
CN118873678A ADC-10
Undisclosed
Undisclosed
Undisclosed
[274]
CN118873678A ADC-11
undisclosed
Undisclosed
Undisclosed
[274]
CN118873678A ADC-12
undisclosed
Undisclosed
Undisclosed
[274]
CN118873678A ADC-13
undisclosed
Undisclosed
Undisclosed
[274]
CN118873678A ADC-14
undisclosed
Undisclosed
Undisclosed
[274]
LT4212552T ADC-2
LT4212552T-ADC-2-PAYLOAD
Undisclosed
Mc-Gly-Gly-Phe-Gly
[275]
LT4212552T ADC-3
LT4212552T ADC10 payload
DNA topoisomerase I (TOP1)
Mc-Gly-Gly-Phe-Gly
[275]
LT4212552T ADC4
LT4212552T-ADC-4-PAYLOAD
Undisclosed
Mc-Gly-Gly-Phe-Gly
[275]
LT4212552T ADC5
LT4212552T ADC10 payload
DNA topoisomerase I (TOP1)
LT4212552T-ADC-5-LINKER
[275]
LT4212552T ADC6
LT4212552T-ADC-6-PAYLOAD
Undisclosed
LT4212552T-ADC-6-LINKER
[275]
LT4212552T ADC7
LT4212552T ADC10 payload
DNA topoisomerase I (TOP1)
LT4212552T-ADC-7-LINKER
[275]
LT4212552T ADC8
LT4212552T ADC10 payload
DNA topoisomerase I (TOP1)
LT4212552T-ADC-8-LINKER
[275]
LT4212552T ADC9
LT4212552T ADC10 payload
DNA topoisomerase I (TOP1)
LT4212552T-ADC-9-LINKER
[275]
LT4212552T ADC10
LT4212552T ADC10 payload
DNA topoisomerase I (TOP1)
LT4212552T-ADC-10-LINKER
[275]
LT4212552T ADC12
LT4212552T-ADC-12-PAYLOAD
Undisclosed
Mc-Gly-Gly-Phe-Gly
[275]
LT4212552T ADC13
LT4212552T ADC13 payload
DNA topoisomerase I (TOP1)
Mc-Gly-Gly-Phe-Gly
[275]
LT4212552T ADC15
LT4212552T ADC37 payload
DNA topoisomerase I (TOP1)
Undisclosed
[275]
LT4212552T ADC16
LT4212552T ADC37 payload
DNA topoisomerase I (TOP1)
Undisclosed
[275]
LT4212552T ADC17
LT4212552T ADC37 payload
DNA topoisomerase I (TOP1)
LT4212552T-ADC-17-LINKER
[275]
LT4212552T ADC18
LT4212552T ADC37 payload
DNA topoisomerase I (TOP1)
LT4212552T-ADC-17-LINKER
[275]
LT4212552T ADC19
LT4212552T ADC37 payload
DNA topoisomerase I (TOP1)
LT4212552T-ADC-19-LINKER
[275]
LT4212552T ADC20
LT4212552T ADC37 payload
DNA topoisomerase I (TOP1)
LT4212552T-ADC-19-LINKER
[275]
LT4212552T ADC21
LT4212552T ADC37 payload
DNA topoisomerase I (TOP1)
LT4212552T-ADC-21-LINKER
[275]
LT4212552T ADC22
LT4212552T ADC37 payload
DNA topoisomerase I (TOP1)
LT4212552T-ADC-21-LINKER
[275]
LT4212552T ADC24
LT4212552T ADC25 payload
DNA topoisomerase I (TOP1)
LT4212552T-ADC-24-LINKER
[275]
LT4212552T ADC25
LT4212552T ADC25 payload
DNA topoisomerase I (TOP1)
LT4212552T-ADC-24-LINKER
[275]
LT4212552T ADC26
LT4212552T ADC49 payload
DNA topoisomerase I (TOP1)
Mc-Gly-Gly-Phe-Gly
[275]
LT4212552T ADC27
LT4212552T ADC49 payload
DNA topoisomerase I (TOP1)
Mc-Gly-Gly-Phe-Gly
[275]
LT4212552T ADC28
LT4212552T ADC49 payload
DNA topoisomerase I (TOP1)
Mc-Gly-Gly-Phe-Gly
[275]
LT4212552T ADC29
LT4212552T ADC49 payload
DNA topoisomerase I (TOP1)
Mc-Gly-Gly-Phe-Gly
[275]
LT4212552T ADC30
LT4212552T ADC49 payload
DNA topoisomerase I (TOP1)
Mc-Gly-Gly-Phe-Gly
[275]
LT4212552T ADC31
LT4212552T ADC49 payload
DNA topoisomerase I (TOP1)
Mc-Gly-Gly-Phe-Gly
[275]
LT4212552T ADC36
LT4212552T ADC37 payload
DNA topoisomerase I (TOP1)
LT4212552T-ADC-36-LINKER
[275]
LT4212552T ADC37
LT4212552T ADC37 payload
DNA topoisomerase I (TOP1)
LT4212552T-ADC-36-LINKER
[275]
LT4212552T ADC39
LT4212552T-ADC-39-PAYLOAD
Undisclosed
Mc-Gly-Gly-Phe-Gly
[275]
LT4212552T ADC40
LT4212552T-ADC-39-PAYLOAD
Undisclosed
Mc-Gly-Gly-Phe-Gly
[275]
LT4212552T ADC41
Topo1 inhibitor B
DNA topoisomerase I (TOP1)
Mc-Gly-Gly-Phe-Gly
[275]
LT4212552T ADC42
Topo1 inhibitor B
DNA topoisomerase I (TOP1)
Mc-Gly-Gly-Phe-Gly
[275]
LT4212552T ADC43
LT4212552T ADC49 payload
DNA topoisomerase I (TOP1)
LT4212552T-ADC-6-LINKER
[275]
LT4212552T ADC44
LT4212552T ADC49 payload
DNA topoisomerase I (TOP1)
HK40112172A+Antibody-drug conjugate (44)+Linker
[275]
LT4212552T ADC46
LT4212552T ADC49 payload
DNA topoisomerase I (TOP1)
Mc-Gly-Gly-Phe-Gly
[275]
LT4212552T ADC47
LT4212552T ADC49 payload
DNA topoisomerase I (TOP1)
Mc-Gly-Gly-Phe-Gly
[275]
LT4212552T ADC49
LT4212552T ADC49 payload
DNA topoisomerase I (TOP1)
Mc-Gly-Gly-Phe-Gly
[275]
Herceptin-RTX-5007
Undisclosed
Undisclosed
Undisclosed
[276]
IGAC-1
IG-L-1 Payload
Undisclosed
IG-L-1 linker
[277]
IGAC-3
Smol006
Eukaryotic peptide chain release factor GTP-binding subunit ERF3A (GSPT1)
MP-Ala-Ala-PAB
[277]
IGAC-5
IG-L-2 Payload
Undisclosed
MP-Ala-Ala-PAB
[277]
IGAC-7
Smol006
Eukaryotic peptide chain release factor GTP-binding subunit ERF3A (GSPT1)
MP-Ala-Ala-PAB
[277]
IGAC-9
IG-L-1 Payload
Undisclosed
IG-L-1 linker
[277]
IGAC-11
IG-L-3 Payload
Undisclosed
IG-L-3 linker
[277]
IGAC-13
IG-L-7 Payload
Undisclosed
MP-Ala-Ala-PAB
[277]
IGAC-15
IG-L-4 Payload
Undisclosed
MP-Ala-Ala-PAB
[277]
IGAC-17
IG-L-5 Payload
Undisclosed
MP-Ala-Ala-PAB
[277]
IGAC-19
IG-L-9 Payload
Undisclosed
MP-Ala-Ala-PAB
[277]
IGAC-21
IG-L-10 Payload
Undisclosed
MP-Ala-Ala-PAB
[277]
IGAC-23
IG-L-11 Payload
Undisclosed
MP-Ala-Ala-PAB
[277]
IGAC-29
IG-L-12 Payload
Undisclosed
MP-Ala-Ala-PAB
[277]
IGAC-31
Smol006
Eukaryotic peptide chain release factor GTP-binding subunit ERF3A (GSPT1)
IG-L-14 linker
[277]
IGAC-33
IG-L-16 Payload
Undisclosed
IG-L-16 linker
[277]
IGAC-35
IG-L-17 Payload
Undisclosed
MP-Ala-Ala-PAB
[277]
IGAC-36
IG-L-13 Payload
Undisclosed
IG-L-13 linker
[277]
IGAC-37
IG-L-15 Payload
Undisclosed
DL18 linker
[277]
IGAC-39
Smol006
Eukaryotic peptide chain release factor GTP-binding subunit ERF3A (GSPT1)
MP-Ala-Ala-PAB
[277]
IGAC-40
IG-L-18 Payload
Undisclosed
IG-L-18 linker
[277]
IGAC-41
undisclosed
Undisclosed
IG-L-19 linker
[277]
IGAC-42
IG-L-18 Payload
Undisclosed
IG-L-20 linker
[277]
IGAC-43
IG-L-18 Payload
Undisclosed
IG-L-21 linker
[277]
IGAC-44
IG-L-18 Payload
Undisclosed
IG-L-22 linker
[277]
IGAC-47
IG-L-26 Payload
Undisclosed
IG-L-26 linker
[277]
IGAC-48
IG-L-23 Payload
Undisclosed
IG-L-3 linker
[277]
IGAC-49
IG-L-18 Payload
Undisclosed
IG-L-25 linker
[277]
IGAC-50
IG-L-36 Payload
Undisclosed
IG-L-36 linker
[277]
IGAC-52
IG-L-36 Payload
Undisclosed
IG-L-37 linker
[277]
IGAC-54
IG-L-38 Payload
Undisclosed
IG-L-38 linker
[277]
IGAC-55
IG-L-39 Payload
Undisclosed
IG-L-38 linker
[277]
IGAC-56
IG-L-79 Payload
Undisclosed
IG-L-47 linker
[277]
IGAC-57
Smol006
Eukaryotic peptide chain release factor GTP-binding subunit ERF3A (GSPT1)
IG-L-16 linker
[277]
IGAC-58
Smol006
Eukaryotic peptide chain release factor GTP-binding subunit ERF3A (GSPT1)
IG-L-63 linker
[277]
IGAC-60
CC-885
Undisclosed
IG-L-54 linker
[277]
IGAC-61
CC-885
Undisclosed
IG-L-58 linker
[277]
IGAC-63
IG-L-79 Payload
Undisclosed
IG-L-46 linker
[277]
IGAC-65
Smol006
Eukaryotic peptide chain release factor GTP-binding subunit ERF3A (GSPT1)
IG-L-65 linker
[277]
IGAC-68
IG-L-71 Payload
Undisclosed
IG-L-71 linker
[277]
IGAC-69
Smol006
Eukaryotic peptide chain release factor GTP-binding subunit ERF3A (GSPT1)
IG-L-68 linker
[277]
IGAC-71
IG-L-70 Payload
Undisclosed
IG-L-70 linker
[277]
IGAC-73
IG-L-48 Payload
Undisclosed
IG-L-36 linker
[277]
IGAC-75
IG-L-45 Payload
Undisclosed
IG-L-45 linker
[277]
IGAC-77
IG-L-40 Payload
Undisclosed
IG-L-40 linker
[277]
IGAC-79
CC-885
Undisclosed
IG-L-42 linker
[277]
IGAC-81
IG-L-41 Payload
Undisclosed
IG-L-41 linker
[277]
IGAC-84
IG-L-43 Payload
Undisclosed
IG-L-43 linker
[277]
IGAC-85
IG-L-44 Payload
Undisclosed
IG-L-44 linker
[277]
IGAC-93
IG-L-18 Payload
Undisclosed
IG-L-25 linker
[277]
IGAC-96
CC-885
Undisclosed
IG-L-73 linker
[277]
IGAC-97
Smol006
Eukaryotic peptide chain release factor GTP-binding subunit ERF3A (GSPT1)
IG-L-74 linker
[277]
IGAC-98
IG-L-79 Payload
Undisclosed
IG-L-75 linker
[277]
IGAC-99
IG-L-76 Payload
Undisclosed
IG-L-76 linker
[277]
IGAC-100
IG-L-79 Payload
Undisclosed
IG-L-77 linker
[277]
IGAC-101
CC-885
Undisclosed
IG-L-74 linker
[277]
IGAC-102
IG-L-79 Payload
Undisclosed
IG-L-74 linker
[277]
IGAC-103
IG-L-80 Payload
Undisclosed
IG-L-74 linker
[277]
IGAC-104
IG-L-81 Payload
Undisclosed
IG-L-81 linker
[277]
IGAC-105
IG-L-82 Payload
Undisclosed
IG-L-82 linker
[277]
JP7560255B2 ControlADC45
Undisclosed
Undisclosed
Undisclosed
[278]
CN113874046B ADC-1
Monomethyl auristatin E
Microtubule (MT)
CN113874046B-ADC-1-LINKER
[279]
CN113874046B ADC-2
CN113874046B-ADC-2-PAYLOAD
Undisclosed
CN113874046B-ADC-2-LINKER
[279]
CN113874046B ADC-3
CN113874046B-ADC-3-PAYLOAD
Undisclosed
CN113874046B-ADC-3-LINKER
[279]
CN113874046B ADC-4
Monomethyl auristatin E
Microtubule (MT)
CN113874046B-ADC-4-LINKER
[279]
CN113874046B ADC-5
CN113874046B-ADC-5-PAYLOAD
Undisclosed
CN113874046B-ADC-5-LINKER
[279]
CN113874046B ADC-6
CN113874046B-ADC-6-PAYLOAD
Undisclosed
CN113874046B-ADC-6-LINKER
[279]
CN113874046B ADC-7
Monomethyl auristatin E
Microtubule (MT)
CN113874046B-ADC-7-LINKER
[279]
CN113453724B ADC-A
CN113453724B-ADCA-PAYLOAD
Undisclosed
CN113453724B-ADCA-LINKER
[280]
CN119630431A ADC-90
CN119630431A-ADC-82-PAYLOAD
Undisclosed
CN119630431A-ADC-82-LINKER
[281]
TWI857167B IC-1
TWI857167B-IC-1-PAYLOAD
Undisclosed
TWI857167B-IC-1-LINKER
[282]
TWI857167B IC-2 2.4
TWI857167B-IC-2-PAYLOAD
Undisclosed
TWI857167B-IC-1-LINKER
[282]
TWI857167B IC-2 4.2
TWI857167B-IC-2-PAYLOAD
Undisclosed
TWI857167B-IC-1-LINKER
[282]
TWI857167B IC-3
TWI857167B-IC-3-PAYLOAD
Undisclosed
Aminobenzazepine-linker Formula II-3
[282]
TWI857167B IC-6
TWI857167B-IC-6-PAYLOAD
Undisclosed
Aminobenzazepine-linker Formula II-3
[282]
TWI857167B IC-7
TWI857167B-IC-7-PAYLOAD
Undisclosed
Aminobenzazepine-linker Formula II-3
[282]
TWI857167B IC-10
TWI857167B-IC-10-PAYLOAD
Undisclosed
TWI857167B-IC-1-LINKER
[282]
TWI857167B IC-11
TWI857167B-IC-11-PAYLOAD
Undisclosed
Aminobenzazepine-linker Formula II-3
[282]
TWI857167B IC-13
TWI857167B-IC-13-PAYLOAD
Undisclosed
Aminobenzazepine-linker Formula II-3
[282]
TWI857167B IC-14
TWI857167B-IC-14-PAYLOAD
Undisclosed
Aminobenzazepine-linker Formula II-3
[282]
TWI857167B IC-15
TWI857167B IC-74 payload
Undisclosed
Aminobenzazepine-linker Formula II-3
[282]
TWI857167B IC-16
TWI857167B-IC-16-PAYLOAD
Undisclosed
Aminobenzazepine-linker Formula II-3
[282]
TWI857167B IC-17
TWI857167B-IC-17-PAYLOAD
Undisclosed
Aminobenzazepine-linker Formula II-3
[282]
TWI857167B IC-18
TWI857167B-IC-18-PAYLOAD
Undisclosed
Aminobenzazepine-linker Formula II-3
[282]
TWI857167B IC-19
TWI857167B-IC-19-PAYLOAD
Undisclosed
Aminobenzazepine-linker Formula II-3
[282]
TWI857167B IC-20
TWI857167B-IC-20-PAYLOAD
Undisclosed
Aminobenzazepine-linker Formula II-3
[282]
TWI857167B IC-21
TWI857167B-IC-21-PAYLOAD
Undisclosed
Aminobenzazepine-linker Formula II-3
[282]
TWI857167B IC-22
TWI857167B-IC-22-PAYLOAD
Undisclosed
Aminobenzazepine-linker Formula II-3
[282]
TWI857167B IC-23
TWI857167B-IC-23-PAYLOAD
Undisclosed
Aminobenzazepine-linker Formula II-3
[282]
TWI857167B IC-24
TWI857167B-IC-24-PAYLOAD
Undisclosed
Aminobenzazepine-linker Formula II-3
[282]
TWI857167B IC-25
TWI857167B-IC-25-PAYLOAD
Undisclosed
Aminobenzazepine-linker Formula II-3
[282]
TWI857167B IC-26
TWI857167B-IC-26-PAYLOAD
Undisclosed
Aminobenzazepine-linker Formula II-3
[282]
TWI857167B IC-27
TWI857167B-IC-27-PAYLOAD
Undisclosed
Aminobenzazepine-linker Formula II-3
[282]
TWI857167B IC-28
TWI857167B-IC-28-PAYLOAD
Undisclosed
Aminobenzazepine-linker Formula II-3
[282]
TWI857167B IC-29
TWI857167B IC-67 payload
Undisclosed
TWI857167B-IC-29-LINKER
[282]
TWI857167B IC-30
TWI857167B IC-38 payload
Undisclosed
TWI857167B-IC-30-LINKER
[282]
TWI857167B IC-31
TWI857167B-IC-31-PAYLOAD
Undisclosed
Aminobenzazepine-linker Formula II-3
[282]
TWI857167B IC-32
TWI857167B-IC-32-PAYLOAD
Undisclosed
TWI857167B-IC-32-LINKER
[282]
TWI857167B IC-34
TWI857167B-IC-34-PAYLOAD
Undisclosed
Aminobenzazepine-linker Formula II-3
[282]
TWI857167B IC-35
TWI857167B-IC-35-PAYLOAD
Undisclosed
TWI857167B-IC-35-LINKER
[282]
TWI857167B IC-36
TWI857167B-IC-36-PAYLOAD
Undisclosed
Aminobenzazepine-linker Formula II-3
[282]
TWI857167B IC-37
TWI857167B-IC-37-PAYLOAD
Undisclosed
Undisclosed
[282]
TWI857167B IC-38
TWI857167B IC-38 payload
Undisclosed
Aminobenzazepine-linker Formula II-72
[282]
TWI857167B IC-39
TWI857167B-IC-39-PAYLOAD
Undisclosed
Undisclosed
[282]
TWI857167B IC-40
TWI857167B-IC-39-PAYLOAD
Undisclosed
Aminobenzazepine-linker Formula II-72
[282]
TWI857167B IC-41
TWI857167B-IC-41-PAYLOAD
Undisclosed
Aminobenzazepine-linker Formula II-72
[282]
TWI857167B IC-42
TWI857167B-IC-42-PAYLOAD
Undisclosed
Aminobenzazepine-linker Formula II-72
[282]
TWI857167B IC-43
TWI857167B-IC-43-PAYLOAD
Undisclosed
Aminobenzazepine-linker Formula II-72
[282]
TWI857167B IC-44
TWI857167B-IC-44-PAYLOAD
Undisclosed
Aminobenzazepine-linker Formula II-3
[282]
TWI857167B IC-45
TWI857167B-IC-45-PAYLOAD
Undisclosed
Aminobenzazepine-linker Formula II-72
[282]
TWI857167B IC-46
TWI857167B-IC-45-PAYLOAD
Undisclosed
Aminobenzazepine-linker Formula II-72
[282]
TWI857167B IC-47
TWI857167B-IC-47-PAYLOAD
Undisclosed
Aminobenzazepine-linker Formula II-72
[282]
TWI857167B IC-48
TWI857167B-IC-48-PAYLOAD
Undisclosed
Aminobenzazepine-linker Formula II-3
[282]
TWI857167B IC-49
TWI857167B-IC-49-PAYLOAD
Undisclosed
Aminobenzazepine-linker Formula II-3
[282]
TWI857167B IC-50
TWI857167B-IC-50-PAYLOAD
Undisclosed
Aminobenzazepine-linker Formula II-3
[282]
TWI857167B IC-51
TWI857167B-IC-51-PAYLOAD
Undisclosed
Aminobenzazepine-linker Formula II-3
[282]
TWI857167B IC-52
TWI857167B-IC-52-PAYLOAD
Undisclosed
Aminobenzazepine-linker Formula II-72
[282]
TWI857167B IC-53
TWI857167B-IC-53-PAYLOAD
Undisclosed
Aminobenzazepine-linker Formula II-72
[282]
TWI857167B IC-54
TWI857167B-IC-54-PAYLOAD
Undisclosed
Aminobenzazepine-linker Formula II-72
[282]
TWI857167B IC-55
TWI857167B-IC-55-PAYLOAD
Undisclosed
Aminobenzazepine-linker Formula II-72
[282]
TWI857167B IC-56
TWI857167B-IC-56-PAYLOAD
Undisclosed
Aminobenzazepine-linker Formula II-72
[282]
TWI857167B IC-57
TWI857167B-IC-55-PAYLOAD
Undisclosed
Aminobenzazepine-linker Formula II-3
[282]
TWI857167B IC-58
TWI857167B-IC-58-PAYLOAD
Undisclosed
Aminobenzazepine-linker Formula II-3
[282]
TWI857167B IC-59
TWI857167B-IC-59-PAYLOAD
Undisclosed
Aminobenzazepine-linker Formula II-72
[282]
TWI857167B IC-60
TWI857167B-IC-60-PAYLOAD
Undisclosed
Aminobenzazepine-linker Formula II-72
[282]
TWI857167B IC-61
TWI857167B IC-67 payload
Undisclosed
TWI857167B-IC-61-LINKER
[282]
TWI857167B IC-62
TWI857167B-IC-62-PAYLOAD
Undisclosed
Aminobenzazepine-linker Formula II-72
[282]
TWI857167B IC-63
TWI857167B-IC-63-PAYLOAD
Undisclosed
Aminobenzazepine-linker Formula II-72
[282]
TWI857167B IC-64
TWI857167B IC-74 payload
Undisclosed
Aminobenzazepine-linker Formula II-72
[282]
TWI857167B IC-65
TWI857167B-IC-65-PAYLOAD
Undisclosed
Aminobenzazepine-linker Formula II-3
[282]
TWI857167B IC-66
TWI857167B-IC-65-PAYLOAD
Undisclosed
TWI857167B-IC-66-LINKER
[282]
TWI857167B IC-67
TWI857167B IC-67 payload
Undisclosed
Aminobenzazepine-linker Formula II-72
[282]
TWI857167B IC-68
TWI857167B-IC-67-PAYLOAD
Undisclosed
Aminobenzazepine-linker Formula II-3
[282]
TWI857167B IC-69
TWI857167B-IC-68-PAYLOAD
Undisclosed
Aminobenzazepine-linker Formula II-3
[282]
TWI857167B IC-70
TWI857167B-IC-69-PAYLOAD
Undisclosed
Aminobenzazepine-linker Formula II-3
[282]
TWI857167B IC-71
TWI857167B-IC-70-PAYLOAD
Undisclosed
TWI857167B-IC-70-LINKER
[282]
TWI857167B IC-72
undisclosed
Undisclosed
TWI857167B-IC-71-LINKER
[282]
TWI857167B IC-73
TWI857167B-IC-69-PAYLOAD
Undisclosed
TWI857167B-IC-72-LINKER
[282]
TWI857167B IC-74
TWI857167B IC-74 payload
Undisclosed
Aminobenzazepine-linker Formula II-82
[282]
TWI857167B IC-75
TWI857167B-IC-74-PAYLOAD
Undisclosed
TWI857167B-IC-70-LINKER
[282]
TWI857167B IC-76
TWI857167B-IC-75-PAYLOAD
Undisclosed
Aminobenzazepine-linker Formula II-3
[282]
TWI857167B IC-77
TWI857167B-IC-50-PAYLOAD
Undisclosed
Aminobenzazepine-linker Formula II-82
[282]
TWI857167B IC-78
TWI857167B-IC-77-PAYLOAD
Undisclosed
Aminobenzazepine-linker Formula II-3
[282]
TWI857167B IC-79
TWI857167B-IC-78-PAYLOAD
Undisclosed
Aminobenzazepine-linker Formula II-3
[282]
TWI857167B IC-80
TWI857167B-IC-79-PAYLOAD
Undisclosed
Aminobenzazepine-linker Formula II-3
[282]
TWI857167B IC-81
TWI857167B-IC-80-PAYLOAD
Undisclosed
Aminobenzazepine-linker Formula II-3
[282]
TWI857167B IC-82
TWI857167B-IC-81-PAYLOAD
Undisclosed
Aminobenzazepine-linker Formula II-3
[282]
TWI857167B IC-83
TWI857167B IC-84 payload
Undisclosed
Aminobenzazepine-linker Formula II-3
[282]
TWI857167B IC-84
TWI857167B IC-84 payload
Undisclosed
TWI857167B-IC-82-LINKER
[282]
TWI857167B IC-85
TWI857167B-IC-85-PAYLOAD
Undisclosed
TWI857167B-IC-82-LINKER
[282]
TWI857167B IC-86
TWI857167B-IC-85-PAYLOAD
Undisclosed
Aminobenzazepine-linker Formula II-82
[282]
TWI857167B IC-87
TWI857167B-IC-86-PAYLOAD
Undisclosed
TWI857167B-IC-85-LINKER
[282]
TWI857167B IC-88
TWI857167B-IC-78-PAYLOAD
Undisclosed
TWI857167B-IC-82-LINKER
[282]
TWI857167B IC-89
TWI857167B-IC-88-PAYLOAD
Undisclosed
Undisclosed
[282]
TWI857167B IC-90
TWI857167B-IC-88-PAYLOAD
Undisclosed
TWI857167B-IC-82-LINKER
[282]
TWI857167B IC-91
TWI857167B-IC-90-PAYLOAD
Undisclosed
Undisclosed
[282]
TWI857167B IC-92
TWI857167B-IC-91-PAYLOAD
Undisclosed
TWI857167B-IC-90-LINKER
[282]
TWI857167B IC-93
TWI857167B-IC-92-PAYLOAD
Undisclosed
TWI857167B-IC-82-LINKER
[282]
TWI857167B IC-94
TWI857167B-IC-93-PAYLOAD
Undisclosed
TWI857167B-IC-82-LINKER
[282]
TWI857167B IC-95
TWI857167B-IC-86-PAYLOAD
Undisclosed
Undisclosed
[282]
TWI857167B IC-96
TWI857167B-IC-95-PAYLOAD
Undisclosed
Undisclosed
[282]
TWI857167B IC-97
TWI857167B-IC-96-PAYLOAD
Undisclosed
TWI857167B-IC-95-LINKER
[282]
TWI857167B IC-98
TWI857167B-IC-63-PAYLOAD
Undisclosed
TWI857167B-IC-96-LINKER
[282]
TWI857167B IC-99
TWI857167B-IC-98-PAYLOAD
Undisclosed
TWI857167B-IC-97-LINKER
[282]
TWI857167B IC-100
TWI857167B-IC-99-PAYLOAD
Undisclosed
Undisclosed
[282]
TWI857167B IC-101
TWI857167B-IC-99-PAYLOAD
Undisclosed
Undisclosed
[282]
TWI857167B IC-102
TWI857167B-IC-101-PAYLOAD
Undisclosed
Undisclosed
[282]
TWI857167B IC-103
TWI857167B-IC-102-PAYLOAD
Undisclosed
TWI857167B-IC-101-LINKER
[282]
TWI857167B IC-104
TWI857167B-IC-95-PAYLOAD
Undisclosed
Undisclosed
[282]
TWI857167B IC-105
TWI857167B-IC-104-PAYLOAD
Undisclosed
Undisclosed
[282]
TWI857167B IC-106
TWI857167B-IC-105-PAYLOAD
Undisclosed
Undisclosed
[282]
TWI857167B IC-107
TWI857167B-IC-106-PAYLOAD
Undisclosed
TWI857167B-IC-105-LINKER
[282]
TWI857167B IC-108
TWI857167B-IC-107-PAYLOAD
Undisclosed
TWI857167B-IC-95-LINKER
[282]
TWI857167B IC-109
TWI857167B-IC-108-PAYLOAD
Undisclosed
Undisclosed
[282]
TWI857167B IC-110
TWI857167B-IC-101-PAYLOAD
Undisclosed
TWI857167B-IC-108-LINKER
[282]
TWI857167B IC-111
TWI857167B-IC-110-PAYLOAD
Undisclosed
Undisclosed
[282]
TWI857167B IC-112
TWI857167B-IC-111-PAYLOAD
Undisclosed
Undisclosed
[282]
TWI857167B IC-113
TWI857167B-IC-111-PAYLOAD
Undisclosed
Undisclosed
[282]
TWI857167B IC-114
TWI857167B-IC-113-PAYLOAD
Undisclosed
Undisclosed
[282]
TWI857167B IC-115
undisclosed
Undisclosed
Undisclosed
[282]
TWI857167B IC-116
TWI857167B-IC-115-PAYLOAD
Undisclosed
Undisclosed
[282]
TWI857167B IC-117
TWI857167B-IC-116-PAYLOAD
Undisclosed
Undisclosed
[282]
TWI857167B IC-118
TWI857167B-IC-117-PAYLOAD
Undisclosed
Undisclosed
[282]
TWI857167B IC-119
TWI857167B-IC-118-PAYLOAD
Undisclosed
Undisclosed
[282]
TWI857167B IC-120
undisclosed
Undisclosed
Undisclosed
[282]
TWI857167B IC-121
TWI857167B-IC-115-PAYLOAD
Undisclosed
Undisclosed
[282]
TWI857167B IC-122
undisclosed
Undisclosed
Undisclosed
[282]
TWI857167B IC-123
undisclosed
Undisclosed
Undisclosed
[282]
EP4487874A1-2
EP4487874A1-2payload
Undisclosed
RU20241285-1-linker
[71]
EP4487874A1-3
undisclosed
Undisclosed
EP4487874A1-3linker
[71]
EP4487874A1-5
EP4487874A1-5payload
Undisclosed
RU20241285-4-linker
[71]
EP4487874A1-6
EP4487874A1-6payload
Undisclosed
RU20241285-4-linker
[71]
EP4487874A1-7
EP4487874A1-7payload
Undisclosed
EP4487874A1-7linker
[71]
EP4487874A1-8
EP4487874A1-8payload
Undisclosed
EP4487874A1-8linker
[71]
EP4487874A1-9
EP4487874A1-9payload
Undisclosed
EP4487874A1-9linker
[71]
EP4487874A1-10
EP4487874A1-10payload
Undisclosed
EP4487874A1-10linker
[71]
EP4487874A1-11
EP4487874A1-11payload
Undisclosed
RU20241285-9-linker
[71]
EP4487874A1-12
DX-8951 derivative (DXd)
DNA topoisomerase 1 (TOP1)
EP4487874A1-12linker
[71]
EP4487874A1-13
EP4487874A1-13payload
Undisclosed
EP4487874A1-13linker
[71]
EP4487874A1-14
DX-8951 derivative (DXd)
DNA topoisomerase 1 (TOP1)
EP4487874A1-14linker
[71]
EP4487874A1-15
EP4487874A1-15payload
Undisclosed
EP4487874A1-15linker
[71]
EP4487874A1-16
EP4487874A1-16payload
Undisclosed
EP4487874A1-10linker
[71]
EP4487874A1-17
EP4487874A1-17payload
Undisclosed
EP4487874A1-17linker
[71]
EP4487874A1-18
Topo1 inhibitor A
DNA topoisomerase I (TOP1)
EP4487874A1-18linker
[71]
EP4487874A1-19
RU20241285-23-payload
DNA topoisomerase I (TOP1)
EP4487874A1-19linker
[71]
EP4487874A1-20
undisclosed
Undisclosed
EP4487874A1-20linker
[71]
EP4487874A1-21
RU20241285-23-payload
DNA topoisomerase I (TOP1)
RU20241285-19-linker
[71]
EP4487874A1-22
Topo1 inhibitor A
DNA topoisomerase I (TOP1)
EP4487874A1-22linker
[71]
EP4487874A1-23
EP4487874A1-16payload
Undisclosed
EP4487874A1-23linker
[71]
EP4487874A1-24
EP4487874A1-16payload
Undisclosed
EP4487874A1-24linker
[71]
EP4487874A1-25
RU20241285-23-payload
DNA topoisomerase I (TOP1)
EP4487874A1-23linker
[71]
EP4487874A1-26
RU20241285-23-payload
DNA topoisomerase I (TOP1)
EP4487874A1-24linker
[71]
38354417 T-DL1
FD1
DNA topoisomerase I (TOP1)
MT-GGFG-AM
[283]
38354417 T-DL3
FD2
DNA topoisomerase I (TOP1)
MT-GGFG-AM
[283]
38354417 T-DL4
FD3
DNA topoisomerase I (TOP1)
MT-GGFG-AM
[283]
38354417 T-DL9
10NH2-11F-Camptothecin
DNA topoisomerase I (TOP1)
MT-GGFG-AM
[283]
38354417 T-DL5
FD5
DNA topoisomerase I (TOP1)
MT-GGFG-AM
[283]
38354417 T-DL6
FD5
DNA topoisomerase I (TOP1)
Mc-Gly-Gly-Phe-Gly
[283]
38354417 T-DL11
FD5
DNA topoisomerase I (TOP1)
MT-GGFG-AM
[283]
38354417 T-DL13
FD6
DNA topoisomerase I (TOP1)
MT-GGFG-AM
[283]
38354417 T-DL14
FD7
DNA topoisomerase I (TOP1)
MT-GGFG-AM
[283]
38354417 T-DL7
DX-8951 derivative (DXd)
DNA topoisomerase 1 (TOP1)
MT-GGFG-AM
[283]
AZO-ADC-0
Monomethyl auristatin E
Microtubule (MT)
Solubilizing group-PEG0-Hypoxia sensitive linker-Azobenzene
[284]
AZO-ADC-2
Monomethyl auristatin E
Microtubule (MT)
Solubilizing group-PEG2-Hypoxia sensitive linker-Azobenzene
[284]
AZO-ADC-4
Monomethyl auristatin E
Microtubule (MT)
Solubilizing group-PEG4-Hypoxia sensitive linker-Azobenzene
[284]
AZO-ADC-6
Monomethyl auristatin E
Microtubule (MT)
Solubilizing group-PEG6-Hypoxia sensitive linker-Azobenzene
[284]
AZO-ADC-8
Monomethyl auristatin E
Microtubule (MT)
Solubilizing group-PEG8-Hypoxia sensitive linker-Azobenzene
[284]
IgG (8)-m- (b-PEG12)-VC-MMAE
Monomethyl auristatin E
Microtubule (MT)
IgG (8)-m- (b-PEG12)-VC-MMAE
[79]
WO2024169913A1 ADC01-01-8
Smol006
Eukaryotic peptide chain release factor GTP-binding subunit ERF3A (GSPT1)
Mc-Val-Cit-PABC
[86]
WO2024169913A1 ADC01-01-4
B19
Eukaryotic peptide chain release factor GTP-binding subunit ERF3A (GSPT1)
Mc-Val-Cit-PABC
[86]
WO2024169913A1 ADC01-02-8
B19
Eukaryotic peptide chain release factor GTP-binding subunit ERF3A (GSPT1)
Mc-Val-Cit-PABC
[86]
WO2024169913A1 ADC01-02-4
B19
Eukaryotic peptide chain release factor GTP-binding subunit ERF3A (GSPT1)
Mc-Val-Ala-PABC
[86]
WO2024169913A1 ADC01-06-8
B19
Eukaryotic peptide chain release factor GTP-binding subunit ERF3A (GSPT1)
Mc-Val-Ala-PABC
[86]
WO2024169913A1 ADC01-06-4
B63
Eukaryotic peptide chain release factor GTP-binding subunit ERF3A (GSPT1)
Mc-Val-Ala-PABC
[86]
WO2024169913A1 ADC01-07-4
B63
Eukaryotic peptide chain release factor GTP-binding subunit ERF3A (GSPT1)
Mc-Val-Ala-PABC
[86]
WO2024169913A1 ADC01-08-8
B19
Eukaryotic peptide chain release factor GTP-binding subunit ERF3A (GSPT1)
(Linker-02)MC-PEG-VA-PAB
[86]
WO2024169913A1 ADC01-08-4
B19
Eukaryotic peptide chain release factor GTP-binding subunit ERF3A (GSPT1)
(Linker-03)SMCC-TAZ-PEG-VC-PAB
[86]
WO2024222841A1 ADC38
(S)B19
Eukaryotic peptide chain release factor GTP-binding subunit ERF3A (GSPT1)
OXDc-VA-PAB (PEG)
[285]
WO2024222841A1 ADC38-4
(S)B19
Eukaryotic peptide chain release factor GTP-binding subunit ERF3A (GSPT1)
OXDc-VA-PAB (PEG)
[285]
WO2024222841A1 ADC39
(S)B19
Eukaryotic peptide chain release factor GTP-binding subunit ERF3A (GSPT1)
OXD-VA-PAB (PEG)
[285]
WO2024222841A1 ADC40
(S)B19
Eukaryotic peptide chain release factor GTP-binding subunit ERF3A (GSPT1)
OXDc-VA-PAB (Glu)
[285]
WO2024222841A1 ADC41
(S)B19
Eukaryotic peptide chain release factor GTP-binding subunit ERF3A (GSPT1)
OXD-VA-PAB (Glu)
[285]
WO2024222841A1 ADC42
B19
Eukaryotic peptide chain release factor GTP-binding subunit ERF3A (GSPT1)
OXDc-VA-PAB (PEG)
[285]
WO2024222841A1 ADC43
(R)B19
Eukaryotic peptide chain release factor GTP-binding subunit ERF3A (GSPT1)
OXDc-VA-PAB (PEG)
[285]
WO2024222841A1 ADC44
B61
Eukaryotic peptide chain release factor GTP-binding subunit ERF3A (GSPT1)
OXDc-VA-PAB (PEG)
[285]
WO2024222841A1 ADC45
B63
Eukaryotic peptide chain release factor GTP-binding subunit ERF3A (GSPT1)
OXDc-VA-PAB (PEG)
[285]
T-ADC-2
(S)B19
Eukaryotic peptide chain release factor GTP-binding subunit ERF3A (GSPT1)
OXDc-VA-PAB (PEG)
[285]
T-ADC
(S)B19
Eukaryotic peptide chain release factor GTP-binding subunit ERF3A (GSPT1)
OXDc-VA-PAB (PEG)
[285]
WO2024222841A1 ADC39-4
(S)B19
Eukaryotic peptide chain release factor GTP-binding subunit ERF3A (GSPT1)
OXD-VA-PAB (PEG)
[285]
WO2024222841A1 ADC40-4
(S)B19
Eukaryotic peptide chain release factor GTP-binding subunit ERF3A (GSPT1)
OXDc-VA-PAB (Glu)
[285]
WO2024222841A1 ADC41-4
(S)B19
Eukaryotic peptide chain release factor GTP-binding subunit ERF3A (GSPT1)
OXD-VA-PAB (Glu)
[285]
WO2024222841A1 ADC42-4
B19
Eukaryotic peptide chain release factor GTP-binding subunit ERF3A (GSPT1)
OXDc-VA-PAB (PEG)
[285]
WO2024222841A1 ADC43-4
(R)B19
Eukaryotic peptide chain release factor GTP-binding subunit ERF3A (GSPT1)
OXDc-VA-PAB (PEG)
[285]
WO2024222841A1 ADC44-4
B61
Eukaryotic peptide chain release factor GTP-binding subunit ERF3A (GSPT1)
OXDc-VA-PAB (PEG)
[285]
CN119343374A ADC-S108
Undisclosed
Undisclosed
Undisclosed
[90]
CN119343374A ADC-S105
Undisclosed
Undisclosed
Undisclosed
[90]
trastuzumab
ADC Info ADC Name Payload Target Linker Ref
WO2024230301A1 ADC-1
Undisclosed
Undisclosed
Undisclosed
[232]
WO2024230301A1 ADC-2
Undisclosed
Undisclosed
Undisclosed
[232]
WO2024230301A1 ADC-3
Undisclosed
Undisclosed
Undisclosed
[232]
WO2024230301A1 ADC-4
Undisclosed
Undisclosed
Undisclosed
[232]
WO2024230301A1 ADC-5
Undisclosed
Undisclosed
Undisclosed
[232]
WO2024230301A1 ADC-6
Undisclosed
Undisclosed
Undisclosed
[232]
WO2024230301A1 ADC-7
Undisclosed
Undisclosed
Undisclosed
[232]
WO2024230301A1 ADC-8
Undisclosed
Undisclosed
Undisclosed
[232]
WO2024230301A1 ADC-9
Undisclosed
Undisclosed
Undisclosed
[232]
WO2024230301A1 ADC-10
Undisclosed
Undisclosed
Undisclosed
[232]
WO2024230301A1 ADC-11
Undisclosed
Undisclosed
Undisclosed
[232]
WO2024230301A1 ADC-12
Undisclosed
Undisclosed
Undisclosed
[232]
WO2024230301A1 ADC-13
Undisclosed
Undisclosed
Undisclosed
[232]
WO2024230301A1 ADC-14
Undisclosed
Undisclosed
Undisclosed
[232]
WO2024230301A1 ADC-15
Undisclosed
Undisclosed
Undisclosed
[232]
WO2024230301A1 ADC-16
Undisclosed
Undisclosed
Undisclosed
[232]
WO2024230301A1 ADC-17
Undisclosed
Undisclosed
Undisclosed
[232]
WO2024230301A1 ADC-18
Undisclosed
Undisclosed
Undisclosed
[232]
WO2024230301A1 ADC-19
Undisclosed
Undisclosed
Undisclosed
[232]
WO2024230301A1 ADC-20
Undisclosed
Undisclosed
Undisclosed
[232]
WO2024230301A1 ADC1a-DAR4
Undisclosed
Undisclosed
Undisclosed
[232]
CN116782954A ADC2-DAR4
Undisclosed
Undisclosed
Undisclosed
[233]
CN116782954A ADC3-DAR4
Undisclosed
Undisclosed
Undisclosed
[233]
CN116782954A ADC4a-DAR4
Undisclosed
Undisclosed
Undisclosed
[233]
CN116782954A ADC4b-DAR4
Undisclosed
Undisclosed
Undisclosed
[233]
CN116782954A ADC5-DAR2
Undisclosed
Undisclosed
Undisclosed
[233]
Trastuzumab-ZY-889
Undisclosed
Undisclosed
Undisclosed
[234]
Trastuzumab-ZY-948
Undisclosed
Undisclosed
Undisclosed
[234]
Trastuzumab-ZY-894
Undisclosed
Undisclosed
Undisclosed
[234]
EP4090377A1 EP4090377A1 221
Undisclosed
Undisclosed
Undisclosed
[41]
Trast-v8-XL06
Undisclosed
Undisclosed
Undisclosed
[41]
Trast-v4- (201)2
Undisclosed
Undisclosed
Undisclosed
[41]
US20240245795A1 Antibody Conjugate 1
Exatecan
DNA topoisomerase 1 (TOP1)
Mc-Val-Cit-PABC
[244]
US20240245795A1 Antibody Conjugate 2
Undisclosed
Undisclosed
Undisclosed
[244]
US20240245795A1 Antibody Conjugate 3
Undisclosed
Undisclosed
Undisclosed
[244]
US20240245795A1 Antibody Conjugate 4
Undisclosed
Undisclosed
Undisclosed
[244]
US20240245795A1 Antibody Conjugate 5
Exatecan
DNA topoisomerase 1 (TOP1)
Undisclosed
[244]
US20240245795A1 Antibody Conjugate 6
Exatecan
DNA topoisomerase 1 (TOP1)
Undisclosed
[244]
US20240245795A1 Antibody Conjugate 7
Antibody Conjugate 7 +Payload
DNA topoisomerase I (TOP1)
Undisclosed
[244]
US20240245795A1 Antibody Conjugate 8
Undisclosed
Undisclosed
Undisclosed
[244]
US20240245795A1 Antibody Conjugate 11
Undisclosed
Undisclosed
Undisclosed
[244]
US20240245795A1 Antibody Conjugate 12
Undisclosed
Undisclosed
Undisclosed
[244]
Trastuzumab-DXD (CN114569739A)
Undisclosed
Undisclosed
Undisclosed
[256]
CN114569739A ADC-1 (trastuzumab)
Undisclosed
Undisclosed
Undisclosed
[256]
CN114569739A ADC-2 (trastuzumab)
Undisclosed
Undisclosed
Undisclosed
[256]
CN114569739A ADC-3 (trastuzumab)
Undisclosed
Undisclosed
Undisclosed
[256]
CN114569739A ADC-4 (trastuzumab)
Undisclosed
Undisclosed
Undisclosed
[256]
CN114569739A ADC-7 (trastuzumab)
Undisclosed
Undisclosed
Undisclosed
[256]
trastuzumab (6-N3-GalNAc)2
ADC Info ADC Name Payload Target Linker Ref
EP4090377A1 EP4090377A1 210
Undisclosed
Undisclosed
Undisclosed
[41]
Trastuzumab (C2)
ADC Info ADC Name Payload Target Linker Ref
Tras (C2)-Cp
Cryptophycin-uD[Dap (Me)]
Undisclosed
Mc-Val-Cit-PABC
[286]
Trastuzumab (C4)
ADC Info ADC Name Payload Target Linker Ref
Tras (C4)-Cp
Cryptophycin-uD[Dap (Me)]
Undisclosed
Mc-Val-Cit-PABC
[286]
Trastuzumab (C8)
ADC Info ADC Name Payload Target Linker Ref
Tras (C8)-Cp
Cryptophycin-uD[Dap (Me)]
Undisclosed
Mc-Val-Cit-PABC
[286]
Tras (C8)-MMAE
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
[286]
Trastuzumab (Positively Charged)
ADC Info ADC Name Payload Target Linker Ref
Positively Charged ADC
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
[216]
Trastuzumab A114C
ADC Info ADC Name Payload Target Linker Ref
Neolymphostin ADC 21
Neolymphostin A
3-Phosphoinositide-dependent protein kinase 1 (PDPK1)
Mc-Val-Cit-PABC-DMEA
[287]
Neolymphostin ADC 22
Neolymphostin A
3-Phosphoinositide-dependent protein kinase 1 (PDPK1)
PEG4-DMEA
[287]
Neolymphostin ADC 23
Neolymphostin A
3-Phosphoinositide-dependent protein kinase 1 (PDPK1)
Mc-Val-Cit-PABC
[287]
Neolymphostin ADC 24
Neolymphostin A
3-Phosphoinositide-dependent protein kinase 1 (PDPK1)
N-Methoxycarbonylmaleimide
[287]
Trastuzumab D265C
ADC Info ADC Name Payload Target Linker Ref
T-D265C-CN-Pro-amanitin
CN-Pro-dideoxy-alpha-amanitin
DNA-directed RNA polymerase II subunit RPB2 (POLR2B); DNA-directed RNA polymerase III subunit RPC7 (POLR3G)
Mal-Val-Ala-PAB
[288]
T-D265C-NH2-Pro-amanitin
NH2-Pro-dideoxy-alpha-amanitin
DNA-directed RNA polymerase II subunit RPB2 (POLR2B); DNA-directed RNA polymerase III subunit RPC7 (POLR3G)
Mc-Val-Ala-PABC
[288]
T-D265C-OH-Pro-amanitin
OH-Pro-dideoxy-alpha-amanitin
DNA-directed RNA polymerase II subunit RPB2 (POLR2B); DNA-directed RNA polymerase III subunit RPC7 (POLR3G)
Mc-Val-Ala-PABC
[288]
trastuzumab GalNProSSMe trast-v5a
ADC Info ADC Name Payload Target Linker Ref
Trast-v5b-XL02
Undisclosed
Undisclosed
Undisclosed
[41]
Trastuzumab I253Q
ADC Info ADC Name Payload Target Linker Ref
Trastuzumab I253Q-MMAE
Monomethyl auristatin E
Microtubule (MT)
Dansylcadaverine-BCN based linker
[289]
Trastuzumab deglycosylated WT-MMAE
Monomethyl auristatin E
Microtubule (MT)
Dansylcadaverine deglycosylated-BCN based linker
[289]
Trastuzumab N297A
ADC Info ADC Name Payload Target Linker Ref
ADC MMAE/F 4+2
Monomethyl auristatin E+Monomethyl auristatin F
Microtubule (MT)
DBCO-PEG3-Glu-Val-Cit-PABC; TCO-PEG3-Glu-Val-Cit-PABC
[290]
ADC MMAE/F 2+4
Monomethyl auristatin E+Monomethyl auristatin F
Microtubule (MT)
DBCO-PEG3-Glu-Val-Cit-PABC; TCO-PEG3-Glu-Val-Cit-PABC
[290]
ADC MMAE/F 2+2
Monomethyl auristatin E+Monomethyl auristatin F
Microtubule (MT)
DBCO-PEG3-Glu-Val-Cit-PABC; TCO-PEG3-Glu-Val-Cit-PABC
[290]
trastuzumab S239C mutant trast-v6
ADC Info ADC Name Payload Target Linker Ref
Trast-v6-XL02
Undisclosed
Undisclosed
Undisclosed
[41]
Trast-v6-XL03
Undisclosed
Undisclosed
C-lock-azide linker
[41]
Trast-v6- (XL05)2
Undisclosed
Undisclosed
Maleimide linker
[41]
Trastuzumab scFv
ADC Info ADC Name Payload Target Linker Ref
scFv (Herceptin)-PE
Pseudomonas exotoxin PE38
Eukaryotic elongation factor 2 kinase (EEF2K)
Undisclosed
[291]
scFv(Herceptin)-PE-STXA
PE15-Stx 2a
Eukaryotic elongation factor 2 kinase (EEF2K)
Undisclosed
[291]
ScFv(trastuzumab)-PE38KDEL
Pseudomonas exotoxin PE38
Eukaryotic elongation factor 2 kinase (EEF2K)
Undisclosed
[19]
trastuzumab trast-v1a
ADC Info ADC Name Payload Target Linker Ref
TCO-trastuzumab trast-v1a-XL11
Undisclosed
Undisclosed
Undisclosed
[41]
trastuzumab trast-v7
ADC Info ADC Name Payload Target Linker Ref
Trast-v7-XL01
Undisclosed
Undisclosed
Undisclosed
[41]
trastuzumab- (azide)2
ADC Info ADC Name Payload Target Linker Ref
EP4090377A1 EP4090377A1 211
Undisclosed
Undisclosed
linker105
[41]
EP4090377A1 EP4090377A1 212
Undisclosed
Undisclosed
Undisclosed
[41]
EP4090377A1 EP4090377A1 213
Undisclosed
Undisclosed
Undisclosed
[41]
EP4090377A1 EP4090377A1 214
Undisclosed
Undisclosed
Undisclosed
[41]
EP4090377A1 EP4090377A1 215
Undisclosed
Undisclosed
Undisclosed
[41]
EP4090377A1 EP4090377A1 216
Undisclosed
Undisclosed
Undisclosed
[41]
EP4090377A1 EP4090377A1 217
Undisclosed
Undisclosed
linker145
[41]
Trastuzumab-A111
ADC Info ADC Name Payload Target Linker Ref
AU2022395626A1 ADC-L2-P2
Monomethyl auristatin E
Microtubule (MT)
H-Tet-Glucuronide
[292]
Trastuzumab-A121
ADC Info ADC Name Payload Target Linker Ref
AU2022395626A1 ADC-H8-P3
Undisclosed
Undisclosed
Undisclosed
[292]
Trastuzumab-A51
ADC Info ADC Name Payload Target Linker Ref
AU2022395626A1 ADC-L1-P2
Monomethyl auristatin E
Microtubule (MT)
H-Tet-Glucuronide
[292]
Trastuzumab-AL1
ADC Info ADC Name Payload Target Linker Ref
IgG1 (trastuzumab)-AL1-MMAE
Monomethyl auristatin E
Microtubule (MT)
Undisclosed
[19]
Trastuzumab-BUPY
ADC Info ADC Name Payload Target Linker Ref
Trastuzumab-BUPY-DM1
Mertansine DM1
Microtubule (MT)
N3-SMCC
[293]
Trastuzumab-BUPY-TAMRA
TAMRA
Undisclosed
N3-PEG3
[293]
Trastuzumab-CpHK
ADC Info ADC Name Payload Target Linker Ref
T-CpHK-Tet-ADC
Monomethyl auristatin E
Microtubule (MT)
Tetrazine-PEG5-Val-Ala-PABC
[294]
T-CpHK-Mal-ADC
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
[294]
Trastuzumab-Fab-cd38
ADC Info ADC Name Payload Target Linker Ref
38501590 Anti-HER2 ARC-FDC (1)
Monomethyl auristatin F
Microtubule (MT)
2'-Cl-araNAD linker
[295]
38501590 Anti-HER2 ARC-FDC (2)
Monomethyl auristatin F
Microtubule (MT)
2'-Cl-araNAD linker
[295]
Trastuzumab-Flexmab
ADC Info ADC Name Payload Target Linker Ref
Trastuzumab-Flexmab-SG3710
SG3199
Human Deoxyribonucleic acid (hDNA)
Mal-PEG8-Val-Ala-PABC
[108]
Trastuzumab-G41
ADC Info ADC Name Payload Target Linker Ref
AU2022395626A1 ADC-L4-P2
Monomethyl auristatin E
Microtubule (MT)
H-Tet-Glucuronide
[292]
Trastuzumab-G42
ADC Info ADC Name Payload Target Linker Ref
AU2022395626A1 ADC-H7-P2
Monomethyl auristatin E
Microtubule (MT)
H-Tet-Glucuronide
[292]
trastuzumab-GalNProSSMe trast-v5a
ADC Info ADC Name Payload Target Linker Ref
Trast-v5b-XL01
Undisclosed
Undisclosed
Undisclosed
[41]
Trast-v5b- (XL05)2 2
Undisclosed
Undisclosed
Undisclosed
[41]
Trastuzumab-H16-K222R-Hg1
ADC Info ADC Name Payload Target Linker Ref
US11365263B2 ADC#2
US11365263B2 ADC#2 payload
Undisclosed
US11365263B2 ADC#3 linker
[296]
US11365263B2 ADC#3
US11365263B2 ADC#3 payload
Undisclosed
US11365263B2 ADC#3 linker
[296]
Trastuzumab-K169
ADC Info ADC Name Payload Target Linker Ref
AU2022395626A1 ADC-L3-P2
Monomethyl auristatin E
Microtubule (MT)
H-Tet-Glucuronide
[292]
Trastuzumab-K249
ADC Info ADC Name Payload Target Linker Ref
AU2022395626A1 ADC-H1-P1
Monomethyl auristatin E
Microtubule (MT)
H-Tet-PEG9-Val-Ala-PAB
[292]
AU2022395626A1 ADC-H1-P2
Monomethyl auristatin E
Microtubule (MT)
H-Tet-Glucuronide
[292]
GlyADC-H1-P2
Monomethyl auristatin E
Microtubule (MT)
H-Tet-Glucuronide
[292]
Trastuzumab-K249&G41
ADC Info ADC Name Payload Target Linker Ref
AU2022395626A1 ADC-H1L4-P2
Monomethyl auristatin E
Microtubule (MT)
H-Tet-Glucuronide
[292]
Trastuzumab-K249&K169
ADC Info ADC Name Payload Target Linker Ref
AU2022395626A1 ADC-H1L3-P2
Monomethyl auristatin E
Microtubule (MT)
H-Tet-Glucuronide
[292]
Trastuzumab-K249&K320
ADC Info ADC Name Payload Target Linker Ref
AU2022395626A1 ADC-H1H4-P2
Monomethyl auristatin E
Microtubule (MT)
H-Tet-Glucuronide
[292]
Trastuzumab-K249&K343
ADC Info ADC Name Payload Target Linker Ref
AU2022395626A1 ADC-H1H5-P2
Monomethyl auristatin E
Microtubule (MT)
H-Tet-Glucuronide
[292]
Trastuzumab-K251
ADC Info ADC Name Payload Target Linker Ref
AU2022395626A1 ADC-H2-P1
Monomethyl auristatin E
Microtubule (MT)
H-Tet-PEG9-Val-Ala-PAB
[292]
Trastuzumab-K291
ADC Info ADC Name Payload Target Linker Ref
AU2022395626A1 ADC-H3-P1
Monomethyl auristatin E
Microtubule (MT)
H-Tet-PEG9-Val-Ala-PAB
[292]
Trastuzumab-K320
ADC Info ADC Name Payload Target Linker Ref
AU2022395626A1 ADC-H4-P1
Monomethyl auristatin E
Microtubule (MT)
H-Tet-PEG9-Val-Ala-PAB
[292]
AU2022395626A1 ADC-H4-P2
Monomethyl auristatin E
Microtubule (MT)
H-Tet-Glucuronide
[292]
GlyADC-H4-P2
Monomethyl auristatin E
Microtubule (MT)
H-Tet-Glucuronide
[292]
Trastuzumab-K320&G41
ADC Info ADC Name Payload Target Linker Ref
AU2022395626A1 ADC-H4L4-P2
Monomethyl auristatin E
Microtubule (MT)
H-Tet-Glucuronide
[292]
Trastuzumab-K320&K169
ADC Info ADC Name Payload Target Linker Ref
AU2022395626A1 ADC-H4L3-P2
Monomethyl auristatin E
Microtubule (MT)
H-Tet-Glucuronide
[292]
Trastuzumab-K343
ADC Info ADC Name Payload Target Linker Ref
AU2022395626A1 ADC-H5-P1
Monomethyl auristatin E
Microtubule (MT)
H-Tet-PEG9-Val-Ala-PAB
[292]
Trastuzumab-P41
ADC Info ADC Name Payload Target Linker Ref
AU2022395626A1 ADC-H6-P2
Monomethyl auristatin E
Microtubule (MT)
H-Tet-Glucuronide
[292]
Trastuzumab-P41&G41
ADC Info ADC Name Payload Target Linker Ref
AU2022395626A1 ADC-H6L4-P2
Monomethyl auristatin E
Microtubule (MT)
H-Tet-Glucuronide
[292]
Trastuzumab-P59
ADC Info ADC Name Payload Target Linker Ref
AU2022395626A1 ADC-L5-P2
Monomethyl auristatin E
Microtubule (MT)
H-Tet-Glucuronide
[292]
Trastuzumab-Qtag2
ADC Info ADC Name Payload Target Linker Ref
Trastuzumab-Qtag2-Alexa 488-cadaverine
Alexa 488-cadaverine
Undisclosed
Undisclosed
[297]
Trastuzumab-Qtag2-MMAE
Monomethyl auristatin E
Microtubule (MT)
PEG4-VC-PAB
[297]
Trastuzumab-Qtag2-DM1
Mertansine DM1
Microtubule (MT)
PEG4-SMCC
[297]
37341172 13d
NAMPT inhibitor 1b
Undisclosed
Undisclosed
[298]
37341172 13f
NAMPT inhibitor 1b
Undisclosed
Undisclosed
[298]
trastuzumab-S239C mutant trast-v6
ADC Info ADC Name Payload Target Linker Ref
Trast-v6-XL01
Undisclosed
Undisclosed
Undisclosed
[41]
Trast-v6-XL12
Undisclosed
Undisclosed
Undisclosed
[41]
Trastuzumabk453del-Qtag2
ADC Info ADC Name Payload Target Linker Ref
Trastuzumabk453del-Qtag2-MMAE
Monomethyl auristatin E
Microtubule (MT)
PEG4-VC-PAB
[297]
Tratuzumab (P41C)
ADC Info ADC Name Payload Target Linker Ref
KR1020250011922A ADC-TRA41C
Undisclosed
Undisclosed
Undisclosed
[299]
KR1020250011922A ADC-S105 masked
Undisclosed
Undisclosed
Undisclosed
[299]
KR1020250011922A ADC-S105 demasked
Undisclosed
Undisclosed
Undisclosed
[299]
KR1020250011922A ADC-S105
Undisclosed
Undisclosed
Undisclosed
[299]
KR1020250011922A ADC-S108
Undisclosed
Undisclosed
Undisclosed
[299]
KR1020250011922A ADC-S109
Undisclosed
Undisclosed
Undisclosed
[299]
KR1020250011922A ADC-S110
Undisclosed
Undisclosed
Undisclosed
[299]
KR1020250011922A ADC-S111
Undisclosed
Undisclosed
Undisclosed
[299]
KR1020250011922A ADC-TRA41C MMP2-treated
Undisclosed
Undisclosed
Undisclosed
[299]
KR1020250011922A ADC-S423 masked
Undisclosed
Undisclosed
Undisclosed
[299]
KR1020250011922A ADC-S423 demasked
Undisclosed
Undisclosed
Undisclosed
[299]
KR1020250011922A ADC-S426 masked
Undisclosed
Undisclosed
Undisclosed
[299]
KR1020250011922A ADC-S426 MMP2-treated
Undisclosed
Undisclosed
Undisclosed
[299]
KR1020250011922A ADC-S424 masked
Undisclosed
Undisclosed
Undisclosed
[299]
KR1020250011922A ADC-S424 demasked
Undisclosed
Undisclosed
Undisclosed
[299]
KR1020250011922A ADC-S425 masked
Undisclosed
Undisclosed
Undisclosed
[299]
KR1020250011922A ADC-S425 demasked
Undisclosed
Undisclosed
Undisclosed
[299]
KR1020250011922A ADC-S424 MMP2 treated
Undisclosed
Undisclosed
Undisclosed
[299]
KR1020250011922A ADC-S425 MMP2 treated
Undisclosed
Undisclosed
Undisclosed
[299]
Trz-HC:p67
ADC Info ADC Name Payload Target Linker Ref
Trz-HC:p67-MMAE
Monomethyl auristatin E
Microtubule (MT)
Undisclosed
[300]
Trz-LC:p67
ADC Info ADC Name Payload Target Linker Ref
Trz-LC:p67-MMAE
Monomethyl auristatin E
Microtubule (MT)
Undisclosed
[300]
WO2015095301A2 ADC-1 antibody
ADC Info ADC Name Payload Target Linker Ref
WO2015095301A2 ADC-1
WO2015095301A2 ADC-1 payload
Undisclosed
WO2015095301A2 ADC-1 linker
[12]
WO2015095301A2 ADC-10 antibody
ADC Info ADC Name Payload Target Linker Ref
WO2015095301A2 ADC-10
WO2015095301A2 ADC-10 payload
Undisclosed
WO2015095301A2 ADC-10 linker
[12]
WO2015095301A2 ADC-11 antibody
ADC Info ADC Name Payload Target Linker Ref
WO2015095301A2 ADC-11
WO2015095301A2 ADC-11 payload
Undisclosed
WO2015095301A2 ADC-11 linker
[12]
WO2015095301A2 ADC-12 antibody
ADC Info ADC Name Payload Target Linker Ref
WO2015095301A2 ADC-12
WO2015095301A2 ADC-12 payload
Undisclosed
WO2015095301A2 ADC-12 linker
[12]
WO2015095301A2 ADC-13 antibody
ADC Info ADC Name Payload Target Linker Ref
WO2015095301A2 ADC-13
WO2015095301A2 ADC-13 payload
Undisclosed
WO2015095301A2 ADC-13 linker
[12]
WO2015095301A2 ADC-14 antibody
ADC Info ADC Name Payload Target Linker Ref
WO2015095301A2 ADC-14
WO2015095301A2 ADC-14 payload
Undisclosed
WO2015095301A2 ADC-14 linker
[12]
WO2015095301A2 ADC-15 antibody
ADC Info ADC Name Payload Target Linker Ref
WO2015095301A2 ADC-15
WO2015095301A2 ADC-15 payload
Undisclosed
WO2015095301A2 ADC-15 linker
[12]
WO2015095301A2 ADC-16 antibody
ADC Info ADC Name Payload Target Linker Ref
WO2015095301A2 ADC-16
WO2015095301A2 ADC-16 payload
Undisclosed
WO2015095301A2 ADC-16 linker
[12]
WO2015095301A2 ADC-17 antibody
ADC Info ADC Name Payload Target Linker Ref
WO2015095301A2 ADC-17
WO2015095301A2 ADC-17 payload
Undisclosed
WO2015095301A2 ADC-17 linker
[12]
WO2015095301A2 ADC-18 antibody
ADC Info ADC Name Payload Target Linker Ref
WO2015095301A2 ADC-18
WO2015095301A2 ADC-18 payload
Undisclosed
WO2015095301A2 ADC-18 linker
[12]
WO2015095301A2 ADC-19 antibody
ADC Info ADC Name Payload Target Linker Ref
WO2015095301A2 ADC-19
WO2015095301A2 ADC-19 payload
Undisclosed
WO2015095301A2 ADC-19 linker
[12]
WO2015095301A2 ADC-2 antibody
ADC Info ADC Name Payload Target Linker Ref
WO2015095301A2 ADC-2
WO2015095301A2 ADC-2 payload
Undisclosed
WO2015095301A2 ADC-2 linker
[12]
WO2015095301A2 ADC-20 antibody
ADC Info ADC Name Payload Target Linker Ref
WO2015095301A2 ADC-20
WO2015095301A2 ADC-20 payload
Undisclosed
WO2015095301A2 ADC-20 linker
[12]
WO2015095301A2 ADC-21 antibody
ADC Info ADC Name Payload Target Linker Ref
WO2015095301A2 ADC-21
WO2015095301A2 ADC-21 payload
Undisclosed
WO2015095301A2 ADC-21 linker
[12]
WO2015095301A2 ADC-22 antibody
ADC Info ADC Name Payload Target Linker Ref
WO2015095301A2 ADC-22
WO2015095301A2 ADC-22 payload
Undisclosed
WO2015095301A2 ADC-22 linker
[12]
WO2015095301A2 ADC-23 antibody
ADC Info ADC Name Payload Target Linker Ref
WO2015095301A2 ADC-23
WO2015095301A2 ADC-23 payload
Undisclosed
WO2015095301A2 ADC-23 linker
[12]
WO2015095301A2 ADC-24 antibody
ADC Info ADC Name Payload Target Linker Ref
WO2015095301A2 ADC-24
WO2015095301A2 ADC-24 payload
Undisclosed
WO2015095301A2 ADC-24 linker
[12]
WO2015095301A2 ADC-25 antibody
ADC Info ADC Name Payload Target Linker Ref
WO2015095301A2 ADC-25
WO2015095301A2 ADC-25 payload
Undisclosed
WO2015095301A2 ADC-25 linker
[12]
WO2015095301A2 ADC-26 antibody
ADC Info ADC Name Payload Target Linker Ref
WO2015095301A2 ADC-26
WO2015095301A2 ADC-26 payload
Undisclosed
WO2015095301A2 ADC-26 linker
[12]
WO2015095301A2 ADC-27 antibody
ADC Info ADC Name Payload Target Linker Ref
WO2015095301A2 ADC-27
WO2015095301A2 ADC-27 payload
Undisclosed
WO2015095301A2 ADC-27 linker
[12]
WO2015095301A2 ADC-3 antibody
ADC Info ADC Name Payload Target Linker Ref
WO2015095301A2 ADC-3
WO2015095301A2 ADC-3 payload
Undisclosed
WO2015095301A2 ADC-3 linker
[12]
WO2015095301A2 ADC-4 antibody
ADC Info ADC Name Payload Target Linker Ref
WO2015095301A2 ADC-4
WO2015095301A2 ADC-4 payload
Undisclosed
WO2015095301A2 ADC-4 linker
[12]
WO2015095301A2 ADC-5 antibody
ADC Info ADC Name Payload Target Linker Ref
WO2015095301A2 ADC-5
WO2015095301A2 ADC-5 payload
Undisclosed
WO2015095301A2 ADC-5 linker
[12]
WO2015095301A2 ADC-6 antibody
ADC Info ADC Name Payload Target Linker Ref
WO2015095301A2 ADC-6
WO2015095301A2 ADC-6 payload
Undisclosed
WO2015095301A2 ADC-6 linker
[12]
WO2015095301A2 ADC-7 antibody
ADC Info ADC Name Payload Target Linker Ref
WO2015095301A2 ADC-7
WO2015095301A2 ADC-7 payload
Undisclosed
WO2015095301A2 ADC-7 linker
[12]
WO2015095301A2 ADC-8 antibody
ADC Info ADC Name Payload Target Linker Ref
WO2015095301A2 ADC-8
WO2015095301A2 ADC-8 payload
Undisclosed
WO2015095301A2 ADC-8 linker
[12]
WO2015095301A2 ADC-9 antibody
ADC Info ADC Name Payload Target Linker Ref
WO2015095301A2 ADC-9
WO2015095301A2 ADC-9 payload
Undisclosed
WO2015095301A2 ADC-9 linker
[12]
WO2015189791A1 ADC-1 antibody
ADC Info ADC Name Payload Target Linker Ref
WO2015189791A1 ADC-1
WO2015189791A1 ADC-1 payload
Undisclosed
WO2015189791A1 ADC-1 linker
[13]
WO2015189791A1 ADC-10 antibody
ADC Info ADC Name Payload Target Linker Ref
WO2015189791A1 ADC-10
WO2015189791A1 ADC-10 payload
Undisclosed
WO2015189791A1 ADC-10 linker
[13]
WO2015189791A1 ADC-11 antibody
ADC Info ADC Name Payload Target Linker Ref
WO2015189791A1 ADC-11
WO2015189791A1 ADC-11 payload
Undisclosed
WO2015189791A1 ADC-11 linker
[13]
WO2015189791A1 ADC-12 antibody
ADC Info ADC Name Payload Target Linker Ref
WO2015189791A1 ADC-12
WO2015189791A1 ADC-12 payload
Undisclosed
WO2015189791A1 ADC-12 linker
[13]
WO2015189791A1 ADC-13 antibody
ADC Info ADC Name Payload Target Linker Ref
WO2015189791A1 ADC-13
WO2015189791A1 ADC-13 payload
Undisclosed
WO2015189791A1 ADC-13 linker
[13]
WO2015189791A1 ADC-14 antibody
ADC Info ADC Name Payload Target Linker Ref
WO2015189791A1 ADC-14
WO2015189791A1 ADC-14 payload
Undisclosed
WO2015189791A1 ADC-14 linker
[13]
WO2015189791A1 ADC-15 antibody
ADC Info ADC Name Payload Target Linker Ref
WO2015189791A1 ADC-15
WO2015189791A1 ADC-15 payload
Undisclosed
WO2015189791A1 ADC-15 linker
[13]
WO2015189791A1 ADC-16 antibody
ADC Info ADC Name Payload Target Linker Ref
WO2015189791A1 ADC-16
WO2015189791A1 ADC-16 payload
Undisclosed
WO2015189791A1 ADC-16 linker
[13]
WO2015189791A1 ADC-17 antibody
ADC Info ADC Name Payload Target Linker Ref
WO2015189791A1 ADC-17
WO2015189791A1 ADC-17 payload
Undisclosed
WO2015189791A1 ADC-17 linker
[13]
WO2015189791A1 ADC-18 antibody
ADC Info ADC Name Payload Target Linker Ref
WO2015189791A1 ADC-18
WO2015189791A1 ADC-18 payload
Undisclosed
WO2015189791A1 ADC-18 linker
[13]
WO2015189791A1 ADC-19 antibody
ADC Info ADC Name Payload Target Linker Ref
WO2015189791A1 ADC-19
WO2015189791A1 ADC-19 payload
Undisclosed
WO2015189791A1 ADC-19 linker
[13]
WO2015189791A1 ADC-2 antibody
ADC Info ADC Name Payload Target Linker Ref
WO2015189791A1 ADC-2
WO2015189791A1 ADC-2 payload
Undisclosed
WO2015189791A1 ADC-2 linker
[13]
WO2015189791A1 ADC-20 antibody
ADC Info ADC Name Payload Target Linker Ref
WO2015189791A1 ADC-20
WO2015189791A1 ADC-20 payload
Undisclosed
WO2015189791A1 ADC-20 linker
[13]
WO2015189791A1 ADC-21 antibody
ADC Info ADC Name Payload Target Linker Ref
WO2015189791A1 ADC-21
WO2015189791A1 ADC-21 payload
Undisclosed
WO2015189791A1 ADC-21 linker
[13]
WO2015189791A1 ADC-22 antibody
ADC Info ADC Name Payload Target Linker Ref
WO2015189791A1 ADC-22
WO2015189791A1 ADC-22 payload
Undisclosed
WO2015189791A1 ADC-22 linker
[13]
WO2015189791A1 ADC-23 antibody
ADC Info ADC Name Payload Target Linker Ref
WO2015189791A1 ADC-23
WO2015189791A1 ADC-23 payload
Undisclosed
WO2015189791A1 ADC-23 linker
[13]
WO2015189791A1 ADC-24 antibody
ADC Info ADC Name Payload Target Linker Ref
WO2015189791A1 ADC-24
WO2015189791A1 ADC-24 payload
Undisclosed
WO2015189791A1 ADC-24 linker
[13]
WO2015189791A1 ADC-25 antibody
ADC Info ADC Name Payload Target Linker Ref
WO2015189791A1 ADC-25
WO2015189791A1 ADC-25 payload
Undisclosed
WO2015189791A1 ADC-25 linker
[13]
WO2015189791A1 ADC-26 antibody
ADC Info ADC Name Payload Target Linker Ref
WO2015189791A1 ADC-26
WO2015189791A1 ADC-26 payload
Undisclosed
WO2015189791A1 ADC-26 linker
[13]
WO2015189791A1 ADC-3 antibody
ADC Info ADC Name Payload Target Linker Ref
WO2015189791A1 ADC-3
WO2015189791A1 ADC-3 payload
Undisclosed
WO2015189791A1 ADC-3 linker
[13]
WO2015189791A1 ADC-38 antibody
ADC Info ADC Name Payload Target Linker Ref
WO2015189791A1 ADC-38
WO2015189791A1 ADC-38 payload
Undisclosed
WO2015189791A1 ADC-38 linker
[13]
WO2015189791A1 ADC-39 antibody
ADC Info ADC Name Payload Target Linker Ref
WO2015189791A1 ADC-39
WO2015189791A1 ADC-39 payload
Undisclosed
WO2015189791A1 ADC-39 linker
[13]
WO2015189791A1 ADC-4 antibody
ADC Info ADC Name Payload Target Linker Ref
WO2015189791A1 ADC-4
WO2015189791A1 ADC-4 payload
Undisclosed
WO2015189791A1 ADC-4 linker
[13]
WO2015189791A1 ADC-41 antibody
ADC Info ADC Name Payload Target Linker Ref
WO2015189791A1 ADC-41
WO2015189791A1 ADC-41 payload
Undisclosed
WO2015189791A1 ADC-41 linker
[13]
WO2015189791A1 ADC-42 antibody
ADC Info ADC Name Payload Target Linker Ref
WO2015189791A1 ADC-42
WO2015189791A1 ADC-42 payload
Undisclosed
WO2015189791A1 ADC-42 linker
[13]
WO2015189791A1 ADC-43 antibody
ADC Info ADC Name Payload Target Linker Ref
WO2015189791A1 ADC-43
WO2015189791A1 ADC-43 payload
Undisclosed
WO2015189791A1 ADC-43 linker
[13]
WO2015189791A1 ADC-44 antibody
ADC Info ADC Name Payload Target Linker Ref
WO2015189791A1 ADC-44
WO2015189791A1 ADC-44 payload
Undisclosed
WO2015189791A1 ADC-44 linker
[13]
WO2015189791A1 ADC-45 antibody
ADC Info ADC Name Payload Target Linker Ref
WO2015189791A1 ADC-45
WO2015189791A1 ADC-45 payload
Undisclosed
WO2015189791A1 ADC-45 linker
[13]
WO2015189791A1 ADC-46 antibody
ADC Info ADC Name Payload Target Linker Ref
WO2015189791A1 ADC-46
WO2015189791A1 ADC-46 payload
Undisclosed
WO2015189791A1 ADC-46 linker
[13]
WO2015189791A1 ADC-47 antibody
ADC Info ADC Name Payload Target Linker Ref
WO2015189791A1 ADC-47
WO2015189791A1 ADC-47 payload
Undisclosed
WO2015189791A1 ADC-47 linker
[13]
WO2015189791A1 ADC-48 antibody
ADC Info ADC Name Payload Target Linker Ref
WO2015189791A1 ADC-48
WO2015189791A1 ADC-48 payload
Undisclosed
WO2015189791A1 ADC-48 linker
[13]
WO2015189791A1 ADC-49 antibody
ADC Info ADC Name Payload Target Linker Ref
WO2015189791A1 ADC-49
WO2015189791A1 ADC-49 payload
Undisclosed
WO2015189791A1 ADC-49 linker
[13]
WO2015189791A1 ADC-5 antibody
ADC Info ADC Name Payload Target Linker Ref
WO2015189791A1 ADC-5
WO2015189791A1 ADC-5 payload
Undisclosed
WO2015189791A1 ADC-5 linker
[13]
WO2015189791A1 ADC-50 antibody
ADC Info ADC Name Payload Target Linker Ref
WO2015189791A1 ADC-50
WO2015189791A1 ADC-50 payload
Undisclosed
WO2015189791A1 ADC-50 linker
[13]
WO2015189791A1 ADC-51 antibody
ADC Info ADC Name Payload Target Linker Ref
WO2015189791A1 ADC-51
WO2015189791A1 ADC-51 payload
Undisclosed
WO2015189791A1 ADC-51 linker
[13]
WO2015189791A1 ADC-52 antibody
ADC Info ADC Name Payload Target Linker Ref
WO2015189791A1 ADC-52
WO2015189791A1 ADC-52 payload
Undisclosed
WO2015189791A1 ADC-52 linker
[13]
WO2015189791A1 ADC-53 antibody
ADC Info ADC Name Payload Target Linker Ref
WO2015189791A1 ADC-53
WO2015189791A1 ADC-53 payload
Undisclosed
WO2015189791A1 ADC-53 linker
[13]
WO2015189791A1 ADC-54 antibody
ADC Info ADC Name Payload Target Linker Ref
WO2015189791A1 ADC-54
WO2015189791A1 ADC-54 payload
Undisclosed
WO2015189791A1 ADC-54 linker
[13]
WO2015189791A1 ADC-55 antibody
ADC Info ADC Name Payload Target Linker Ref
WO2015189791A1 ADC-55
WO2015189791A1 ADC-55 payload
Undisclosed
WO2015189791A1 ADC-55 linker
[13]
WO2015189791A1 ADC-56 antibody
ADC Info ADC Name Payload Target Linker Ref
WO2015189791A1 ADC-56
WO2015189791A1 ADC-56 payload
Undisclosed
WO2015189791A1 ADC-56 linker
[13]
WO2015189791A1 ADC-57 antibody
ADC Info ADC Name Payload Target Linker Ref
WO2015189791A1 ADC-57
WO2015189791A1 ADC-57 payload
Undisclosed
WO2015189791A1 ADC-57 linker
[13]
WO2015189791A1 ADC-58 antibody
ADC Info ADC Name Payload Target Linker Ref
WO2015189791A1 ADC-58
WO2015189791A1 ADC-58 payload
Undisclosed
WO2015189791A1 ADC-58 linker
[13]
WO2015189791A1 ADC-59 antibody
ADC Info ADC Name Payload Target Linker Ref
WO2015189791A1 ADC-59
WO2015189791A1 ADC-59 payload
Undisclosed
WO2015189791A1 ADC-59 linker
[13]
WO2015189791A1 ADC-6 antibody
ADC Info ADC Name Payload Target Linker Ref
WO2015189791A1 ADC-6
WO2015189791A1 ADC-6 payload
Undisclosed
WO2015189791A1 ADC-6 linker
[13]
WO2015189791A1 ADC-60 antibody
ADC Info ADC Name Payload Target Linker Ref
WO2015189791A1 ADC-60
WO2015189791A1 ADC-60 payload
Undisclosed
WO2015189791A1 ADC-60 linker
[13]
WO2015189791A1 ADC-62 antibody
ADC Info ADC Name Payload Target Linker Ref
WO2015189791A1 ADC-62
WO2015189791A1 ADC-62 payload
Undisclosed
WO2015189791A1 ADC-62 linker
[13]
WO2015189791A1 ADC-65 antibody
ADC Info ADC Name Payload Target Linker Ref
WO2015189791A1 ADC-65
WO2015189791A1 ADC-65 payload
Undisclosed
WO2015189791A1 ADC-65 linker
[13]
WO2015189791A1 ADC-7 antibody
ADC Info ADC Name Payload Target Linker Ref
WO2015189791A1 ADC-7
WO2015189791A1 ADC-7 payload
Undisclosed
WO2015189791A1 ADC-7 linker
[13]
WO2015189791A1 ADC-8 antibody
ADC Info ADC Name Payload Target Linker Ref
WO2015189791A1 ADC-8
WO2015189791A1 ADC-8 payload
Undisclosed
WO2015189791A1 ADC-8 linker
[13]
WO2015189791A1 ADC-9 antibody
ADC Info ADC Name Payload Target Linker Ref
WO2015189791A1 ADC-9
WO2015189791A1 ADC-9 payload
Undisclosed
WO2015189791A1 ADC-9 linker
[13]
ADC Info ADC Name Payload Target Linker Ref
XMT-1519 Conjugate 1
Undisclosed
Undisclosed
Undisclosed
[4]
ZA202500114A-mAb-1
ADC Info ADC Name Payload Target Linker Ref
ZA202500114A-ADC-1
Monomethyl auristatin E
Microtubule (MT)
Undisclosed
[238]
ZA202500114A-ADC-2
Undisclosed
Undisclosed
Undisclosed
[238]
Zanidatamab
ADC Info ADC Name Payload Target Linker Ref
Zanidatamab-ADC-Tb3-1
Zanidatamab-ADC-Tb3-1 payload
Undisclosed
Zanidatamab-ADC-Tb3-1 linker
[7]
Zanidatamab-ADC-Tb3-2
Zanidatamab-ADC-Tb3-2 payload
Undisclosed
Zanidatamab-ADC-Tb3-2 linker
[7]
Zanidatamab-ADC-Tb3-3
Zanidatamab-ADC-Tb3-3 payload
Undisclosed
Zanidatamab-ADC-Tb3-3 linker
[7]
Zanidatamab-ADC-Tb3-4
Zanidatamab-ADC-Tb3-4 payload
Undisclosed
Zanidatamab-ADC-Tb3-4 linker
[7]
Zanidatamab-ADC-Tb3-5
Zanidatamab-ADC-Tb3-5 payload
Undisclosed
Zanidatamab-ADC-Tb3-5 linker
[7]
Zanidatamab-ADC-Tb3-6
Zanidatamab-ADC-Tb3-6 payload
Undisclosed
Zanidatamab-ADC-Tb3-6 linker
[7]
Zanidatamab-ADC-Tb3-7
Zanidatamab-ADC-Tb3-7 payload
Undisclosed
Zanidatamab-ADC-Tb3-7 linker
[7]
Zanidatamab-ADC-Tb3-8
Zanidatamab-ADC-Tb3-8 payload
Undisclosed
Zanidatamab-ADC-Tb3-8 linker
[7]
Zanidatamab-ADC-Tb3-9
Zanidatamab-ADC-Tb3-9 payload
Undisclosed
Zanidatamab-ADC-Tb3-9 linker
[7]
Zanidatamab-ADC-Tb3-10
Zanidatamab-ADC-Tb3-10 payload
Undisclosed
Zanidatamab-ADC-Tb3-10 linker
[7]
ADC Info ADC Name Payload Target Linker Ref
ZHER2-Gly3-VC-PAB-MMAF
Monomethyl auristatin F
Microtubule (MT)
Gly3-VC-PAB
[301]
ZHER2-Gly3-VC-PAB-MMAE
Monomethyl auristatin E
Microtubule (MT)
Gly3-VC-PAB
[301]
ZHER2-ABD
ADC Info ADC Name Payload Target Linker Ref
ZHER2-ABD-mcMMAF
Monomethyl auristatin F
Microtubule (MT)
Maleimido-caproyl
[302]
ZHER2-ABD-mcMMAE
Monomethyl auristatin E
Microtubule (MT)
Maleimido-caproyl
[302]
ZHER2:342-Cupid-His
ADC Info ADC Name Payload Target Linker Ref
ZHER2:342-Cupid-His-Ax-SiPc
Silicon Phthalocyanine
Undisclosed
Psyche-Ax
[303]
Zr-labeled trastuzumab
ADC Info ADC Name Payload Target Linker Ref
89Zr-DFO-T-DM1
Mertansine DM1
Microtubule (MT)
Undisclosed
[145]
Undisclosed
ADC Info ADC Name Payload Target Linker Ref
Recombinant anti-HER2 humanized mAb-DM1
Mertansine DM1
Microtubule (MT)
Undisclosed
MT-5111
Shiga toxin B subunit (StxB)
Ribosome (RB)
Undisclosed
KM254-ADC
Undisclosed
Undisclosed
Undisclosed
[304]
Xl-250
Undisclosed
Undisclosed
Undisclosed
[305]
Anti-HER2 antibody-drug conjugate (XDCExplorer)
Undisclosed
Undisclosed
Undisclosed
[306]
YB1-ADC-HER2
Undisclosed
Undisclosed
Undisclosed
[307]
Biparatopic HER2/HER2 antibody drug conjugate
Undisclosed
Undisclosed
Undisclosed
[308]
Anti-HER2-4AP ADC
Undisclosed
Undisclosed
Undisclosed
[309]
Anti-HER2 antibody drug conjugate (NBE-Therapeutics)
Undisclosed
Undisclosed
Undisclosed
[310]
Anti-HER2 antibody-drug conjugate (Mersana Therapeutics/Genentech)
Undisclosed
Undisclosed
Undisclosed
[311]
Mabion-HER2 ADC
Undisclosed
Undisclosed
Undisclosed
[312]
Antibody drug conjugate targeting HER2 (IntoCell)
Undisclosed
Undisclosed
Undisclosed
[313]
TE-1218
Undisclosed
Undisclosed
Undisclosed
[314]
TE-1112
Undisclosed
Undisclosed
Undisclosed
[315]
Second Generation HER2-Directed Antibody-Drug conjugate
Undisclosed
Undisclosed
Undisclosed
[316]
Chloromethylbenz-Indoline Dimer Antibody Drug conjugate
Undisclosed
Undisclosed
Undisclosed
[317]
XB3-001
Undisclosed
Undisclosed
Undisclosed
[318]
ANT-043
Undisclosed
Undisclosed
Undisclosed
[319]
AbGn-110
Undisclosed
Undisclosed
Undisclosed
[320]
CTAT-ADC
Mertansine DM1
Microtubule (MT)
Undisclosed
[321]
Humanized Anti-HER2 Mab-Maytansine Conjugate
Mertansine DM1
Microtubule (MT)
Undisclosed
[322]
DAN-311
Camptothecin
DNA topoisomerase 1 (TOP1)
Undisclosed
[323]
JAB-BX400
STING agonist
Stimulator of interferon genes protein (STING1)
Undisclosed
[324]
QBK249-G
Undisclosed
Undisclosed
Undisclosed
[325]
Antibody-drug conjugate (Scripps)
Undisclosed
Undisclosed
Undisclosed
[326]
FS-1502
Monomethyl auristatin F
Microtubule (MT)
Undisclosed
ZV-0203
Undisclosed
Undisclosed
Undisclosed
[328]
FDA022-BB05
Undisclosed
Undisclosed
Undisclosed
[329]
HS630
Mertansine DM1
Microtubule (MT)
Undisclosed
[330]
CN114106088A ADC6
Tubulin inhibitor B
Microtubule (MT)
CN114106088A+ADC1+Linker
[347]
CN114106088A ADC7
Tubulin inhibitor B
Microtubule (MT)
CN114106088A+ADC2+Linker
[347]
CN114106088A ADC8
Tubulin inhibitor B
Microtubule (MT)
CN114106088A+ADC3+Linker
[347]
CN114106088A ADC9
Tubulin inhibitor B
Microtubule (MT)
CN114106088A+ADC4+Linker
[347]
CN114106088A ADC10
Tubulin inhibitor B
Microtubule (MT)
CN114106088A+ADC5+Linker
[347]
US12195552B2 ADC41
undisclosed
Undisclosed
Undisclosed
[348]
US12195552B2 ADC42
undisclosed
Undisclosed
Undisclosed
[348]
US12195552B2 ADC43
undisclosed
Undisclosed
Undisclosed
[348]
US12195552B2 ADC44
undisclosed
Undisclosed
Undisclosed
[348]
US12195552B2 ADC45
undisclosed
Undisclosed
Undisclosed
[348]
US12195552B2 ADC46
undisclosed
Undisclosed
Undisclosed
[348]
US12195552B2 ADC47
undisclosed
Undisclosed
Undisclosed
[348]
US12195552B2 ADC48
undisclosed
Undisclosed
Undisclosed
[348]
BR122024023391 antibody-drug conjugate (1)
undisclosed
Undisclosed
Undisclosed
[349]
WO2024118785A3 Lot1
Undisclosed
Undisclosed
Undisclosed
[69]
WO2024118785A3 Lot8
Undisclosed
Undisclosed
Undisclosed
[69]
WO2024118785A3 Lot9
Undisclosed
Undisclosed
Undisclosed
[69]
WO2024118785A3 Lot13
Undisclosed
Undisclosed
Undisclosed
[69]
WO2024118785A3 Lot15
Undisclosed
Undisclosed
Undisclosed
[69]
WO2024118785A3 Lot16
Undisclosed
Undisclosed
Undisclosed
[69]
WO2024118785A3 Lot17
Undisclosed
Undisclosed
Undisclosed
[69]
WO2024118785A3 Lot25
Undisclosed
Undisclosed
Undisclosed
[69]
WO2024118785A3 Lot26
Undisclosed
Undisclosed
Undisclosed
[69]
WO2024118785A3 Lot27
Undisclosed
Undisclosed
Undisclosed
[69]
WO2024118785A3 Lot28
P9
Undisclosed
Undisclosed
[69]
WO2024118785A3 Lot29
Undisclosed
Undisclosed
Undisclosed
[69]
WO2024118785A3 Lot30
Undisclosed
Undisclosed
Undisclosed
[69]
WO2024118785A3 Lot31
Undisclosed
Undisclosed
Undisclosed
[69]
WO2024118785A3 Lot32
Undisclosed
Undisclosed
Undisclosed
[69]
WO2024118785A3 Lot37
Undisclosed
Undisclosed
Undisclosed
[69]
WO2024118785A3 Lot44
Undisclosed
Undisclosed
Undisclosed
[69]
WO2024118785A3 Lot45
Undisclosed
Undisclosed
Undisclosed
[69]
WO2024118785A3 Lot46
Undisclosed
Undisclosed
Undisclosed
[69]
WO2024118785A3 Lot47
P9
Undisclosed
Undisclosed
[69]
WO2024118785A3 Lot51
Undisclosed
Undisclosed
Undisclosed
[69]
WO2024118785A3 Lot60
P9
Undisclosed
Undisclosed
[69]
WO2024118785A3 Lot63
P9
Undisclosed
Undisclosed
[69]
WO2024118785A3 Lot72
Undisclosed
Undisclosed
Undisclosed
[69]
WO2024118785A3 Lot73
Undisclosed
Undisclosed
Undisclosed
[69]
WO2024118785A3 Lot81
Undisclosed
Undisclosed
Undisclosed
[69]
WO2024118785A3 Lot82
P9
Undisclosed
Undisclosed
[69]
WO2024118785A3 Lot83
P9
Undisclosed
Undisclosed
[69]
WO2024118785A3 Lot84
Undisclosed
Undisclosed
Undisclosed
[69]
WO2024118785A3 Lot85
Undisclosed
Undisclosed
Undisclosed
[69]
WO2024118785A3 Lot86
P9
Undisclosed
Undisclosed
[69]
WO2024118785A3 Lot87
P9
Undisclosed
Undisclosed
[69]
WO2024118785A3 Lot88
Undisclosed
Undisclosed
Undisclosed
[69]
WO2024118785A3 Lot89
Undisclosed
Undisclosed
Undisclosed
[69]
WO2024118785A3 Lot90
Undisclosed
Undisclosed
Undisclosed
[69]
undisclosed
ADC Info ADC Name Payload Target Linker Ref
H-1-VcMMAE
Undisclosed
Undisclosed
Undisclosed
[327]
H-3-VcMMAE
Undisclosed
Undisclosed
Undisclosed
[327]
H-4-VcMMAE
Undisclosed
Undisclosed
Undisclosed
[327]
JY201
Undisclosed
Undisclosed
Mc-Val-Cit-PABC
[86]
Anti-Her2_ (Q295)_AsnAsnPABC_MMAE
Monomethyl auristatin E
Microtubule (MT)
AsnAsnPABC
[331]
Anti-Her2_ (Q295)_AsnAlaPABC_MMAE
Monomethyl auristatin E
Microtubule (MT)
AsnAlaPABC
[331]
Antl-Her2_ (0295)_ValAlaPABC_MMAE
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Ala-PABC
[331]
Anti-Her2_AsnAsnPABC_MMAE
Monomethyl auristatin E
Microtubule (MT)
AsnAsnPABC
[331]
Anti-Her2_AsnAlaPABC_MMAE
Monomethyl auristatin E
Microtubule (MT)
AsnAlaPABC
[331]
Anti-Her2_ValCitPABC_MMAE
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
[331]
HER2-11
WL-14
Undisclosed
Undisclosed
[332]
HER2-STINGa
STINGa
Undisclosed
Undisclosed
[333]
HER2-B
TLR7/8 agonist B
Undisclosed
Succinimidyl-4- (N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
[334]
HER2-A
TLR7/8 agonist A
Undisclosed
Succinimidyl-4- (N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
[334]
HER2-A (Fc null)
TLR7/8 agonist A
Undisclosed
Succinimidyl-4- (N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
[334]
HLX91-048 ADC (DAR 4)
HLX91-048
Undisclosed
Undisclosed
[335]
HLX91-048 ADC (DAR 8)
HLX91-048
Undisclosed
Undisclosed
[335]
aHer2- (AL6-LP1)n
DX-8951 derivative (DXd)
DNA topoisomerase 1 (TOP1)
US20240269308A1 aHer2- (AL6-LP1)n Linker
[336]
aHer2- (AL6-LP15)n
DX-8951 derivative (DXd)
DNA topoisomerase 1 (TOP1)
US20240269308A1 aHer2- (AL6-LP15)n Linker
[336]
aHer2- (AL6-LP13)n
DX-8951 derivative (DXd)
DNA topoisomerase 1 (TOP1)
US20240269308A1 aHer2- (AL6-LP13)n Linker
[336]
aHer2- (AL7-LP1)n
DX-8951 derivative (DXd)
DNA topoisomerase 1 (TOP1)
US20240269308A1 aHer2- (AL6-LP1)n Linker
[336]
aHer2- (AL7-LP13)n
DX-8951 derivative (DXd)
DNA topoisomerase 1 (TOP1)
US20240269308A1 aHer2- (AL6-LP13)n Linker
[336]
aHer2- (AL7-LP2)n
CP1412
Undisclosed
US20240269308A1 aHer2- (AL6-LP1)n Linker
[336]
aHer2- (AL7-LP3)n
CP1408
Undisclosed
US20240269308A1 aHer2- (AL6-LP1)n Linker
[336]
aHer2- (AL7-LP4)n
CP1409
Undisclosed
US20240269308A1 aHer2- (AL6-LP1)n Linker
[336]
aHer2- (AL7-LP5)n
CP1436
DNA topoisomerase I (TOP1)
US20240269308A1 aHer2- (AL7-LP5)n Linker
[336]
aHer2- (AL7-LP7)n
CP1411
Undisclosed
US20240269308A1 aHer2- (AL6-LP1)n Linker
[336]
aHer2- (AL7-LP9)n
CP1422
Undisclosed
US20240269308A1 aHer2- (AL7-LP5)n Linker
[336]
aHer2- (AL7-LP12)n
CP1436
DNA topoisomerase I (TOP1)
US20240269308A1 aHer2- (AL7-LP5)n Linker
[336]
aHer2- (AL7-LP5D)n
CP1436
DNA topoisomerase I (TOP1)
US20240269308A1 aHer2- (AL7-LP5D)n Linker
[336]
aHer2- (AL4c-LP1B)n
DX-8951 derivative (DXd)
DNA topoisomerase 1 (TOP1)
US20240269308A1 aHer2- (AL4c-LP1B)n Linker
[336]
aHer2- (AL4c-LP13C)n
DX-8951 derivative (DXd)
DNA topoisomerase 1 (TOP1)
US20240269308A1 aHer2- (AL4c-LP13C)n Linker
[336]
aHer2- (AL11a-LP1)n
DX-8951 derivative (DXd)
DNA topoisomerase 1 (TOP1)
US20240269308A1 aHer2- (AL6-LP1)n Linker
[336]
aHer2- (AL11a-LP13)n
DX-8951 derivative (DXd)
DNA topoisomerase 1 (TOP1)
US20240269308A1 aHer2- (AL6-LP13)n Linker
[336]
aHer2- (AL11a-LP15)n
DX-8951 derivative (DXd)
DNA topoisomerase 1 (TOP1)
US20240269308A1 aHer2- (AL6-LP15)n Linker
[336]
aHer2- (BL1-LP1)n
DX-8951 derivative (DXd)
DNA topoisomerase 1 (TOP1)
US20240269308A1 aHer2- (AL6-LP1)n Linker
[336]
aHer2- (BL1-LP13)n
DX-8951 derivative (DXd)
DNA topoisomerase 1 (TOP1)
US20240269308A1 aHer2- (AL6-LP13)n Linker
[336]
aHer2- (BL3b-LP1)n
DX-8951 derivative (DXd)
DNA topoisomerase 1 (TOP1)
US20240269308A1 aHer2- (AL6-LP1)n Linker
[336]
HK40112818A Anti-Her2-AL1- LP9
US12209180B2 P3
Undisclosed
Anti-Her2-AL1- LP9 LINKER
[337]
HK40112818A Anti-Her2-AL1- LP4
US12209180B2 P3
Undisclosed
Anti-Her2-AL1- LP4 LINKER
[337]
HK40112818A Anti-Her2-AL1- LP3
US12209180B2 P3
Undisclosed
Anti-Her2-AL1- LP3 LINKER
[337]
HK40112818A Anti-Her2-AL1- LP1
US12209180B2 P3
Undisclosed
Anti-Her2-AL1- LP1 LINKER
[337]
HK40112818A Anti-Her2-BL2- LP1
US12209180B2 P3
Undisclosed
Anti-Her2-AL1- LP1 LINKER
[337]
HK40112818A Anti-Her2-AL1- LP2
US12209180B2 P3
Undisclosed
Anti-Her2-AL1- LP2 LINKER
[337]
HK40112818A Anti-Her2-AL1- LP20
US12209180B2 P3
Undisclosed
Anti-Her2-AL1- LP20 LINKER
[337]
HK40112818A Anti-Her2-AL1- LP22
US12209180B2 P3
Undisclosed
Anti-Her2-AL1- LP22 linker
[337]
HK40112818A Anti-Her2-BL2- LP22
US12209180B2 P3
Undisclosed
Anti-Her2-AL1- LP22 linker
[337]
HK40112818A Anti-Her2-AL1- LP10
US12209180B2 P3
Undisclosed
Anti-Her2-AL1- LP10 linker
[337]
HK40112818A Anti-Her2-AL1- LP11
US12209180B2 P3
Undisclosed
Anti-Her2-AL1- LP11 linker
[337]
HK40112818A Anti-Her2-AL1- LP12
US12209180B2 P3
Undisclosed
Anti-Her2-AL1- LP12 linker
[337]
HK40112818A Anti-Her2-AL1- LP23
Undisclosed
Undisclosed
Anti-Her2-AL1- LP23 linker
[337]
HK40112818A Anti-Her2-AL1- LP24
Undisclosed
Undisclosed
Anti-Her2-AL1- LP24 linker
[337]
HK40112818A Anti-Her2-AL1- LP25
Undisclosed
Undisclosed
Anti-Her2-AL1- LP25 linker
[337]
HK40112818A Anti-Her2-AL1- LP26
Undisclosed
Undisclosed
Anti-Her2-AL1- LP26 linker
[337]
HK40112818A Anti-Her2-AL1- LP28
Undisclosed
Undisclosed
Anti-Her2-AL1- LP28 linker
[337]
Control-AL1- LP28
Undisclosed
Undisclosed
Anti-Her2-AL1- LP28 linker
[337]
HK40112818A Anti-Her2-BL21- LP28
Undisclosed
Undisclosed
Anti-Her2-AL1- LP28 linker
[337]
HK40112818A Anti-Her2-AL1- LP30
Undisclosed
Undisclosed
Anti-Her2-AL1- LP30 linker
[337]
HK40112818A Anti-Her2-AL1- LP32
Undisclosed
Undisclosed
Anti-Her2-AL1- LP32 linker
[337]
HK40112818A Anti-Her2-BL2- LP32
Undisclosed
Undisclosed
Anti-Her2-AL1- LP32 linker
[337]
HK40112818A Anti-Her2-AL1- LP34
Undisclosed
Undisclosed
Anti-Her2-AL1- LP32 linker
[337]
HK40112818A Anti-Her2-AL1- LP35
Undisclosed
Undisclosed
Anti-Her2-AL1- LP35 LINKER linker
[337]
HK40112818A Anti-Her2-AL1- LP36
Undisclosed
Undisclosed
Anti-Her2-AL1- LP36 linker
[337]
HK40112818A Anti-Her2-AL1- LP37
Undisclosed
Undisclosed
Anti-Her2-AL1- LP37 linker
[337]
HK40112818A Anti-Her2-AL1- LP38
Undisclosed
Undisclosed
Anti-Her2-AL1- LP38 linker
[337]
HK40112818A Anti-Her2-BL2- LP38
Undisclosed
Undisclosed
Anti-Her2-AL1- LP38 linker
[337]
HK40112818A Anti-Her2-AL1- LP39
Undisclosed
Undisclosed
Anti-Her2-AL1- LP41 linker
[337]
HK40112818A Anti-Her2-BL2- LP39
Undisclosed
Undisclosed
Undisclosed
[337]
HK40112818A Anti-Her2-AL1- LP41
Undisclosed
Undisclosed
Anti-Her2-AL1- LP40 linker
[337]
HK40112818A Anti-Her2-BL2- LP41
Undisclosed
Undisclosed
Anti-Her2-AL1- LP41 linker
[337]
HK40112818A Anti-Her2-LP16
US12209180B2 P3
Undisclosed
Anti-Her2-LP16 linker
[337]
HK40112818A Anti-Her2-LP21
Undisclosed
Undisclosed
Anti-Her2-LP21 linker
[337]
HK40112818A Anti-Her2-LP27
Undisclosed
Undisclosed
Anti-Her2-LP27 linker
[337]
HK40112818A Anti-Her2-LP31
Undisclosed
Undisclosed
Anti-Her2-LP31 linker
[337]
HK40112818A Anti-Her2-qLP18
Undisclosed
Undisclosed
Undisclosed
[337]
CA2975383C example16
Tubulin inhibitor A
Undisclosed
Undisclosed
[338]
CA2975383C example17
Tubulin inhibitor A
Undisclosed
Undisclosed
[338]
CA2975383C example19
Tubulin inhibitor C
Undisclosed
Undisclosed
[338]
CA2975383C example64
CA2975383C example64 payload
Undisclosed
Undisclosed
[338]
CA2975383C example21
Tubulin inhibitor A
Undisclosed
Undisclosed
[338]
CA2975383C example22
Tubulin inhibitor A
Undisclosed
Undisclosed
[338]
CA2975383C example23
Tubulin inhibitor A
Undisclosed
Undisclosed
[338]
CA2975383C example24
CA2975383C example24 payload
Undisclosed
Undisclosed
[338]
CA2975383C example28
Tubulin inhibitor C
Undisclosed
Undisclosed
[338]
CA2975383C example65
Tubulin inhibitor C
Undisclosed
Undisclosed
[338]
WO2024043319A1 78
Undisclosed
Undisclosed
Undisclosed
[339]
H-1-MMAF
Undisclosed
Undisclosed
Undisclosed
[327]
H-3-MMAF
Undisclosed
Undisclosed
Undisclosed
[327]
H-4-MMAF
Undisclosed
Undisclosed
Undisclosed
[327]
Maa-C6-Val-Ala-PAB-MMAE
Monomethyl auristatin E
Microtubule (MT)
Maa-C6-Val-Ala-PAB
[78]
Maa-C6-Val-Cit-PAB-MMAE
Monomethyl auristatin E
Microtubule (MT)
Maa-C6-Val-Cit-PAB
[78]
Mf-C6-Val-Ala-PAB-MMAE
Monomethyl auristatin E
Microtubule (MT)
Mm-C6-Val-Ala-PAB
[78]
Mf-C3-Val-Ala-PAB-MMAE
Monomethyl auristatin E
Microtubule (MT)
Mm-C3-Val-Ala-PAB
[78]
Mf-C6-Val-Cit-PAB-MMAE
Monomethyl auristatin E
Microtubule (MT)
Mf-C6-Val-Cit-PAB
[78]
Mm-C6-Val-Ala-PAB-MMAE
Monomethyl auristatin E
Microtubule (MT)
Mm-C6-Val-Ala-PAB
[78]
Mm-C3-Val-Ala-PAB-MMAE
Monomethyl auristatin E
Microtubule (MT)
Mm-C3-Val-Ala-PAB
[78]
Mm-C6-Val-Cit-PAB-MMAE
Monomethyl auristatin E
Microtubule (MT)
Mm-C6-Val-Cit-PAB
[78]
JY201b
Undisclosed
Undisclosed
Mc-Val-Cit-PABC
[86]
Ab[AL- LP1] 4
Exatecan
DNA topoisomerase 1 (TOP1)
Undisclosed
[340]
Ab[AL- LP2] 4
Exatecan
DNA topoisomerase 1 (TOP1)
Undisclosed
[340]
Ab[AL- LP3] 4
Exatecan
DNA topoisomerase 1 (TOP1)
Undisclosed
[340]
Ab[AL- LP4] 4
Exatecan
DNA topoisomerase 1 (TOP1)
Undisclosed
[340]
Ab[AL- LP8] 4
Exatecan
DNA topoisomerase 1 (TOP1)
Undisclosed
[340]
Ab[AL- LP9] 4
Exatecan
DNA topoisomerase 1 (TOP1)
Undisclosed
[340]
Ab[AL- LP3]
Exatecan
DNA topoisomerase 1 (TOP1)
Undisclosed
[340]
Ab[AL- LP8]
Exatecan
DNA topoisomerase 1 (TOP1)
Undisclosed
[340]
Ab[AL- LP9]
DX-8951 derivative (DXd)
DNA topoisomerase 1 (TOP1)
Undisclosed
[340]
Ab[AL2- LP1] 4
Exatecan
DNA topoisomerase 1 (TOP1)
Undisclosed
[340]
Ab[AL2- LP17]n
DX-8951 derivative (DXd)
DNA topoisomerase 1 (TOP1)
Undisclosed
[340]
Ab[AL2- LP17]
DX-8951 derivative (DXd)
DNA topoisomerase 1 (TOP1)
Undisclosed
[340]
JP2025502147A aHer2 Ab
Undisclosed
Undisclosed
Undisclosed
[340]
Isotype Control Ab
Undisclosed
Undisclosed
Undisclosed
[340]
aHer2 (Handle)n
Undisclosed
Undisclosed
Undisclosed
[340]
Isotype Control- (Handle)n
Undisclosed
Undisclosed
Undisclosed
[340]
JP2025502147A ADC1
undisclosed
Undisclosed
Undisclosed
[340]
JP2025502147A ADC2
Undisclosed
Undisclosed
Undisclosed
[340]
JP2025502147A ADC3
undisclosed
Undisclosed
Undisclosed
[340]
Isotype Control ADC
Undisclosed
Undisclosed
Undisclosed
[340]
JP2025502147A ADC4
Undisclosed
Undisclosed
Undisclosed
[340]
JP2025502147A ADC5
Exatecan
DNA topoisomerase 1 (TOP1)
Undisclosed
[340]
JP2025502147A ADC6
Exatecan
DNA topoisomerase 1 (TOP1)
Undisclosed
[340]
JP2025502147A ADC7
Exatecan
DNA topoisomerase 1 (TOP1)
Undisclosed
[340]
JP2025502147A ADC8
Exatecan
DNA topoisomerase 1 (TOP1)
Undisclosed
[340]
HER2-L078-055
Undisclosed
Undisclosed
Undisclosed
[341]
HER2-L078-056
Undisclosed
Undisclosed
Undisclosed
[341]
HER2-L078-062
Undisclosed
Undisclosed
Undisclosed
[341]
HER2-L078-063
Undisclosed
Undisclosed
Undisclosed
[341]
HER2-SET0218 (1)
Undisclosed
Undisclosed
Undisclosed
[341]
STI1499-SET0218 6.2-6.4
Undisclosed
Undisclosed
Undisclosed
[341]
HER2-L078-030-LT
Undisclosed
Undisclosed
Undisclosed
[341]
HER2-L078-044
Undisclosed
Undisclosed
Undisclosed
[341]
HER2-L078-045
Undisclosed
Undisclosed
Undisclosed
[341]
HER2-L078-057
Undisclosed
Undisclosed
Undisclosed
[341]
HER2-L078-058
Undisclosed
Undisclosed
Undisclosed
[341]
HER2-L078-059
Undisclosed
Undisclosed
Undisclosed
[341]
HER2-L078-064
Undisclosed
Undisclosed
Undisclosed
[341]
HER2-L078-065LT
Undisclosed
Undisclosed
Undisclosed
[341]
HER2-L078-066LT
Undisclosed
Undisclosed
Undisclosed
[341]
HER2-SET0218 (2)
Undisclosed
Undisclosed
Undisclosed
[341]
STI1499-SET0218 3.8-4.1
Undisclosed
Undisclosed
Undisclosed
[341]
HER2-L079-018
Undisclosed
Undisclosed
Undisclosed
[341]
HER2-L079-019
Undisclosed
Undisclosed
Undisclosed
[341]
HER2-L079-027
Undisclosed
Undisclosed
Undisclosed
[341]
HER2-L079-034
Undisclosed
Undisclosed
Undisclosed
[341]
HER2-L079-035
Undisclosed
Undisclosed
Undisclosed
[341]
HER2-L079-040
Undisclosed
Undisclosed
Undisclosed
[341]
HER2-L078-121
Undisclosed
Undisclosed
Undisclosed
[341]
HER2-L078-118
Undisclosed
Undisclosed
Undisclosed
[341]
HER2-L078-119
Undisclosed
Undisclosed
Undisclosed
[341]
HER2-L078-120
Undisclosed
Undisclosed
Undisclosed
[341]
HER2-L078-177
Undisclosed
Undisclosed
Undisclosed
[341]
HER2-L078-130
Undisclosed
Undisclosed
Undisclosed
[341]
HER2-L078-123
Undisclosed
Undisclosed
Undisclosed
[341]
HER2-L078-163
Undisclosed
Undisclosed
Undisclosed
[341]
HER2-L078-164
Undisclosed
Undisclosed
Undisclosed
[341]
HER2-L078-173
Undisclosed
Undisclosed
Undisclosed
[341]
HER2-L078-170
Undisclosed
Undisclosed
Undisclosed
[341]
HER2-L078-171
Undisclosed
Undisclosed
Undisclosed
[341]
HER2-L078-178
Undisclosed
Undisclosed
Undisclosed
[341]
HER2-L078-182
Undisclosed
Undisclosed
Undisclosed
[341]
HER2-L081-034
Undisclosed
Undisclosed
Undisclosed
[341]
HER2-L081-036
Undisclosed
Undisclosed
Undisclosed
[341]
HER2-L081-038
Undisclosed
Undisclosed
Undisclosed
[341]
HER2-Dxd
DX-8951 derivative (DXd)
DNA topoisomerase 1 (TOP1)
Undisclosed
[341]
US20230233540A1+ADC
Undisclosed
Undisclosed
Mc-Gly-Gly-Phe-Gly
[342]
Her2-E380C-L443C
Undisclosed
Undisclosed
Undisclosed
[343]
Her2-L443C 1
Undisclosed
Undisclosed
Undisclosed
[343]
Her2-E380C 1.9
Undisclosed
Undisclosed
Undisclosed
[343]
Her2-Q347C 2
Undisclosed
Undisclosed
Undisclosed
[343]
Her2-Q347C
Undisclosed
Undisclosed
Undisclosed
[343]
Her2-Y373C 1.6
Undisclosed
Undisclosed
Undisclosed
[343]
Her2-Y373C 1.9
Undisclosed
Undisclosed
Undisclosed
[343]
Her2-E380C 2
Undisclosed
Undisclosed
Undisclosed
[343]
Her2-E380C+L443C
Undisclosed
Undisclosed
Undisclosed
[343]
Her2-K392C 2
Undisclosed
Undisclosed
Undisclosed
[343]
Her2-K392C 1.9
Undisclosed
Undisclosed
Undisclosed
[343]
Her2-K392C+L443C
Undisclosed
Undisclosed
Undisclosed
[343]
Her2-L398C+L443C
Undisclosed
Undisclosed
Undisclosed
[343]
Her2-N421C 2
Undisclosed
Undisclosed
Undisclosed
[343]
Her2-N421C 2.1
Undisclosed
Undisclosed
Undisclosed
[343]
Her2-L443C 2
Undisclosed
Undisclosed
Undisclosed
[343]
Her2-L443C 3
Undisclosed
Undisclosed
Undisclosed
[343]
Her2-kappa-A111C
Undisclosed
Undisclosed
Undisclosed
[343]
Her2-kappa-A111C+Q347C
Undisclosed
Undisclosed
Undisclosed
[343]
Her2-kappa-A111C+K392C
Undisclosed
Undisclosed
Undisclosed
[343]
Her2-kappa-A111C+L443C
Undisclosed
Undisclosed
Undisclosed
[343]
Her2-kappa-K149C
Undisclosed
Undisclosed
Undisclosed
[343]
Her2-kappa-K183C
Undisclosed
Undisclosed
Undisclosed
[343]
Her2-kappa-K183C+L443C
Undisclosed
Undisclosed
Undisclosed
[343]
Her2-kappa-K207C
Undisclosed
Undisclosed
Undisclosed
[343]
Her2-kappa-K207C+L443C
Undisclosed
Undisclosed
Undisclosed
[343]
WO2024138000A1 aHer2 Ab
Undisclosed
Undisclosed
Undisclosed
[344]
aHer2- (AL11a)4
Undisclosed
Undisclosed
Undisclosed
[344]
aHer2- (AL2a)4
Undisclosed
Undisclosed
Undisclosed
[344]
aHer2- (AL3a)3.94
Undisclosed
Undisclosed
Undisclosed
[344]
aHer2- (AL7)4
Undisclosed
Undisclosed
Undisclosed
[344]
aHer2- (AL6)3.6
Undisclosed
Undisclosed
Undisclosed
[344]
aHer2- (BL1)3.9
Undisclosed
Undisclosed
Undisclosed
[344]
aHer2- (BL3b)3.8
Undisclosed
Undisclosed
Undisclosed
[344]
aHer2- (AL6-LP1)3.6
aHer2- (AL6-LP1)<sub>3.6</sub> Payload
Undisclosed
aHer2- (AL6-LP1)<sub>3.6</sub> Linker
[344]
aHer2- (AL6-LP13D)6.2
DX-8951 derivative (DXd)
DNA topoisomerase 1 (TOP1)
aHer2- (AL6-LP13D)<sub>6.2</sub> Linker
[344]
aHer2- (AL6-LP13)6.5
aHer2- (AL6-LP1)<sub>3.6</sub> Payload
Undisclosed
aHer2- (AL6-LP13)<sub>6.5</sub> Linker
[344]
aHer2- (AL7-LP1)3.7
aHer2- (AL6-LP1)<sub>3.6</sub> Payload
Undisclosed
aHer2- (AL7-LP1)<sub>3.7</sub> Linker
[344]
aHer2- (AL7-LP13)7.3
aHer2- (AL6-LP1)<sub>3.6</sub> Payload
Undisclosed
aHer2- (AL7-LP13)<sub>7.3</sub> Linker
[344]
aHer2- (AL7-LP2)3.83
aHer2- (AL7-LP2)<sub>3.83</sub> Payload
Undisclosed
aHer2- (AL7-LP2)<sub>3.83</sub> Linker
[344]
aHer2- (AL7-LP3)3.88
DX-8951 derivative (DXd)
DNA topoisomerase 1 (TOP1)
aHer2- (AL7-LP2)<sub>3.83</sub> Linker
[344]
aHer2- (AL7-LP4)3.84
DX-8951 derivative (DXd)
DNA topoisomerase 1 (TOP1)
aHer2- (AL7-LP2)<sub>3.83</sub> Linker
[344]
aHer2- (AL7-LP5)3.80
aHer2- (AL7-LP5)<sub>3.80</sub> Payload
Undisclosed
aHer2- (AL7-LP5)<sub>3.80</sub> Linker
[344]
aHer2- (AL7-LP7)3.70
aHer2- (AL7-LP7)<sub>3.70</sub> Payload
Undisclosed
aHer2- (AL7-LP2)<sub>3.83</sub> Linker
[344]
aHer2- (AL7-LP9)3.81
undisclosed
Undisclosed
aHer2- (AL7-LP2)<sub>3.83</sub> Linker
[344]
aHer2- (AL7-LP12)3.82
aHer2- (AL7-LP12)<sub>3.82</sub> Payload
Undisclosed
aHer2- (AL7-LP12)<sub>3.82</sub> Linker
[344]
aHer2- (AL7-LP5D)3.89
aHer2- (AL7-LP5D)<sub>3.89</sub> Payload
Undisclosed
aHer2- (AL7-LP12)<sub>3.82</sub> Linker
[344]
aHer2- (AL7-LP5D)3.90
aHer2- (AL7-LP5D)<sub>3.89</sub> Payload
Undisclosed
aHer2- (AL7-LP12)<sub>3.82</sub> Linker
[344]
aHer2- (AL4c-LP1B)3.49
aHer2- (AL4c-LP1B)<sub>3.49</sub> Payload
Undisclosed
aHer2- (AL4c-LP1B)<sub>3.49</sub> Linker
[344]
aHer2- (AL4c-LP13C)7.07
undisclosed
Undisclosed
aHer2- (AL4c-LP13C)<sub>7.07</sub> Linker
[344]
aHer2- (AL4c-LP13C)7.11
undisclosed
Undisclosed
aHer2- (AL4c-LP13C)<sub>7.07</sub> Linker
[344]
aHer2- (AL11a-LP1)4
aHer2- (AL6-LP1)<sub>3.6</sub> Payload
Undisclosed
aHer2- (AL7-LP2)<sub>3.83</sub> Linker
[344]
aHer2- (AL11a-LP13)7.8
aHer2- (AL6-LP1)<sub>3.6</sub> Payload
Undisclosed
aHer2- (AL11a-LP13)<sub>7.8</sub> Linker
[344]
aHer2- (AL11a-LP15)7.6
DX-8951 derivative (DXd)
DNA topoisomerase 1 (TOP1)
aHer2- (AL11a-LP15)<sub>7.6</sub> Linker
[344]
aHer2- (BL1-LP1)7.7
aHer2- (AL6-LP1)<sub>3.6</sub> Payload
Undisclosed
aHer2- (BL1-LP1)<sub>7.7</sub> Linker
[344]
aHer2- (BL1-LP13)14.88
aHer2- (AL6-LP1)<sub>3.6</sub> Payload
Undisclosed
aHer2- (BL1-LP13)<sub>14.88</sub> Linker
[344]
aHer2- (BL3b-LP1)7.5
aHer2- (AL4c-LP1B)<sub>3.49</sub> Payload
Undisclosed
aHer2- (BL3b-LP1)<sub>7.5</sub> Linker
[344]
aHer2 1- (Mc-GGFG-DXD)7.7
DX-8951 derivative (DXd)
DNA topoisomerase 1 (TOP1)
Mc-Gly-Gly-Phe-Gly
[344]
aHer2 2- (Mc-GGFG-DXD)7.7
DX-8951 derivative (DXd)
DNA topoisomerase 1 (TOP1)
Mc-Gly-Gly-Phe-Gly
[344]
aHer2 3- (Mc-GGFG-DXD)7.7
DX-8951 derivative (DXd)
DNA topoisomerase 1 (TOP1)
Mc-Gly-Gly-Phe-Gly
[344]
aHer2 1- (Mc-GGFG-DXD)7.1
DX-8951 derivative (DXd)
DNA topoisomerase 1 (TOP1)
Mc-Gly-Gly-Phe-Gly
[344]
aHer2 2- (Mc-GGFG-DXD)7.1
DX-8951 derivative (DXd)
DNA topoisomerase 1 (TOP1)
Mc-Gly-Gly-Phe-Gly
[344]
aHer2 3- (Mc-GGFG-DXD)7.1
DX-8951 derivative (DXd)
DNA topoisomerase 1 (TOP1)
Mc-Gly-Gly-Phe-Gly
[344]
AU2017341000B2 ADC (1)
DX-8951 derivative (DXd)
DNA topoisomerase 1 (TOP1)
Mc-Gly-Gly-Phe-Gly
[345]
TW202500135A-1
TW202500135A-1 payload
Undisclosed
Mc-Gly-Gly-Phe-Gly
[346]
LN401-31-1
Tubulin inhibitor B
Microtubule (MT)
CN114106088A+ADC1+Linker
[347]
LN401-31-2
Tubulin inhibitor B
Microtubule (MT)
CN114106088A+ADC2+Linker
[347]
LN401-90-5
Tubulin inhibitor B
Microtubule (MT)
CN114106088A+ADC3+Linker
[347]
LN401-90-6
Tubulin inhibitor B
Microtubule (MT)
CN114106088A+ADC4+Linker
[347]
LN401-90-4
Tubulin inhibitor B
Microtubule (MT)
CN114106088A+ADC5+Linker
[347]
US12195552B2 ADC1
Undisclosed
Undisclosed
Undisclosed
[254]
US12195552B2 ADC2
Undisclosed
Undisclosed
Undisclosed
[348]
US12195552B2 ADC3
Undisclosed
Undisclosed
Undisclosed
[348]
US12195552B2 ADC4
Undisclosed
Undisclosed
Undisclosed
[348]
US12195552B2 ADC5
Undisclosed
Undisclosed
Undisclosed
[348]
US12195552B2 ADC6
Undisclosed
Undisclosed
Undisclosed
[348]
US12195552B2 ADC7
Undisclosed
Undisclosed
Undisclosed
[348]
US12195552B2 ADC8
Undisclosed
Undisclosed
Undisclosed
[348]
US12195552B2 ADC9
Undisclosed
Undisclosed
Undisclosed
[348]
US12195552B2 ADC10
Undisclosed
Undisclosed
Undisclosed
[348]
US12195552B2 ADC11
Undisclosed
Undisclosed
Undisclosed
[348]
US12195552B2 ADC12
Undisclosed
Undisclosed
Undisclosed
[348]
US12195552B2 ADC13
Undisclosed
Undisclosed
Undisclosed
[348]
US12195552B2 ADC14
Undisclosed
Undisclosed
Undisclosed
[348]
US12195552B2 ADC15
Undisclosed
Undisclosed
Undisclosed
[348]
US12195552B2 ADC16
Undisclosed
Undisclosed
Undisclosed
[348]
US12195552B2 ADC17
Undisclosed
Undisclosed
Undisclosed
[348]
US12195552B2 ADC18
Undisclosed
Undisclosed
Undisclosed
[348]
US12195552B2 ADC19
Undisclosed
Undisclosed
Undisclosed
[348]
US12195552B2 ADC20
Undisclosed
Undisclosed
Undisclosed
[348]
US12195552B2 ADC21
Undisclosed
Undisclosed
Undisclosed
[348]
US12195552B2 ADC22
Undisclosed
Undisclosed
Undisclosed
[348]
US12195552B2 ADC23
Undisclosed
Undisclosed
Undisclosed
[348]
US12195552B2 ADC24
Undisclosed
Undisclosed
Undisclosed
[348]
US12195552B2 ADC25
Undisclosed
Undisclosed
Undisclosed
[348]
US12195552B2 ADC26
Undisclosed
Undisclosed
Undisclosed
[348]
US12195552B2 ADC27
Undisclosed
Undisclosed
Undisclosed
[348]
US12195552B2 ADC28
Undisclosed
Undisclosed
Undisclosed
[348]
US12195552B2 ADC29
Undisclosed
Undisclosed
Undisclosed
[348]
US12195552B2 ADC30
Undisclosed
Undisclosed
Undisclosed
[348]
US12195552B2 ADC31
Undisclosed
Undisclosed
Undisclosed
[348]
US12195552B2 ADC32
Undisclosed
Undisclosed
Undisclosed
[348]
US12195552B2 ADC33
Undisclosed
Undisclosed
Undisclosed
[348]
US12195552B2 ADC34
Undisclosed
Undisclosed
Undisclosed
[348]
US12195552B2 ADC35
Undisclosed
Undisclosed
Undisclosed
[348]
US12195552B2 ADC36
Undisclosed
Undisclosed
Undisclosed
[348]
US12195552B2 ADC37
Undisclosed
Undisclosed
Undisclosed
[348]
US12195552B2 ADC38
Undisclosed
Undisclosed
Undisclosed
[348]
US12195552B2 ADC39
Undisclosed
Undisclosed
Undisclosed
[348]
US12195552B2 ADC40
Undisclosed
Undisclosed
Undisclosed
[348]
30kmPEG (SCAHer2 (1)xSCAHer2 (2))-2 (Val-Cit-PAB-DEA-SN38)
Active metabolite of irinotecan SN38
DNA topoisomerase 1 (TOP1)
Undisclosed
[350]
30kmPEG (SCAHer2 (1)xSCAHer2 (2))-3 (Val-Cit-PAB-DEA-SN38)
Active metabolite of irinotecan SN38
DNA topoisomerase 1 (TOP1)
Undisclosed
[350]
Anti-HER-N297Q-Ex18
Undisclosed
Undisclosed
Undisclosed
[351]
Anti-HER-N297Q-Ex27
Undisclosed
Undisclosed
Undisclosed
[351]
SG11202200215QA ADC1
Ceritinib
Undisclosed
SG11202200215QA ADC5 linker
[352]
SG11202200215QA ADC2
MK4827
Undisclosed
SG11202200215QA ADC5 linker
[352]
SG11202200215QA ADC3
Active metabolite of irinotecan SN38
DNA topoisomerase 1 (TOP1)
SG11202200215QA ADC3 linker
[352]
SG11202200215QA ADC4
Exatecan
DNA topoisomerase 1 (TOP1)
SG11202200215QA ADC5 linker
[352]
SG11202200215QA ADC5
DX-8951 derivative (DXd)
DNA topoisomerase 1 (TOP1)
SG11202200215QA ADC5 linker
[352]
WO2021260582A1 ADC-1
Exatecan
DNA topoisomerase 1 (TOP1)
Mc-Gly-Gly-Phe-Gly
[353]
Production of the antibody-drug conjugate (1)
undisclosed
Undisclosed
Undisclosed
[354]
References
Ref 1 Antibody-drug conjugates (A2DCs) with enzymatically cleavable groups
Ref 2 A HER2 Specific Nanobody-Drug Conjugate: Site-Selective Bioconjugation and In Vitro Evaluation in Breast Cancer Models
Ref 3 Anthracycline disulfide intermediates, antibody-drug conjugates and methods
Ref 4 Antibody drug conjugates comprising STING agonists, combinations and methods of use
Ref 5 Pharmaceutical composition of antibody-drug conjugates
Ref 6 Targeting HER2 Expressing Tumors with a Potent Drug Conjugate Based on an Albumin Binding Domain-Derived Affinity Protein. Pharmaceutics. 2021 Nov 3;13(11):1847.
Ref 7 Bioactive substance conjugate, preparation method therefor and use thereof; 2022-08-18.
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Ref 9 Effect of vitamin D analog (1alpha hydroxy D5) immunoconjugated to Her-2 antibody on breast cancer. Int J Cancer. 2004 Mar 1;108(6):922-9. doi: 10.1002/ijc.11590.
Ref 10 Heteroaryl sulfone-based conjugation handles, methods for their preparation, and their use in synthesizing antibody drug conjugates
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Ref 12 Cytotoxic peptides and conjugates thereof.
Ref 13 Auristatin derivatives and conjugates thereof.
Ref 14 Cysteine engineered antibodies and conjugates.
Ref 15 Oligosaccharide linkers, linker-payloads comprising the linkers, and glycan chain-remodeled antibody-drug conjugates, preparation methods and uses thereof
Ref 16 Sculpting a Uniquely Reactive Cysteine Residue for Site-Specific Antibody Conjugation. Bioconjug Chem. 2022 Jun 15;33(6):1192-1200.
Ref 17 Application of a Biocatalytic Strategy for the Preparation of Tiancimycin-Based Antibody-Drug Conjugates Revealing Key Insights into Structure-Activity Relationships. J Med Chem. 2023 Jan 26;66(2):1562-1573. doi: 10.1021/acs.jmedchem.2c01771.
Ref 18 A single-chain fab derived drug conjugate for HER2 specific delivery
Ref 19 Antibody-drug conjugates with HER2-targeting antibodies from synthetic antibody libraries are highly potent against HER2-positive human gastric tumor in xenograft models. MAbs. 2019 Jan;11(1):153-165. doi: 10.1080/19420862.2018.1541370. Epub 2018 Nov 8.
Ref 20 Introduction to basic information on ADC drug ADC2202
Ref 21 Phosphate based linkers for intracellular delivery of drug conjugates; 2015-10-08.
Ref 22 Intratumoral Payload Concentration Correlates with the Activity of Antibody-Drug Conjugates. Mol Cancer Ther. 2018 Mar;17(3):677-685. doi: 10.1158/1535-7163.MCT-17-0697. Epub 2018 Jan 18.
Ref 23 Covalent linkers in antibody-drug conjugates and methods of making and using the same.
Ref 24 Antibody drug conjugate and application thereof.
Ref 25 Site-specific antibody-drug conjugation through glycoengineering.
Ref 26 Glutamic acid-valine-citrulline linkers ensure stability and efficacy of antibody-drug conjugates in mice. Nat Commun. 2018 Jun 28;9(1):2512. doi: 10.1038/s41467-018-04982-3.
Ref 27 Tridentate connexon and use thereof.
Ref 28 Preparation and characterization of antibody-drug conjugates acting on HER2-positive cancer cells. PLoS One. 2020 Sep 28;15(9):e0239813. doi: 10.1371/journal.pone.0239813. eCollection 2020.
Ref 29 Stable and Potent Selenomab-Drug Conjugates. Cell Chem Biol. 2017 Apr 20;24(4):433-442.e6. doi: 10.1016/j.chembiol.2017.02.012.
Ref 30 Site-specific antibody-drug conjugation through glycoengineering
Ref 31 Amatoxin antibody-drug conjugates and uses thereof; 2020-10-29.
Ref 32 Genetically Encoded Azide Containing Amino Acid in Mammalian Cells Enables Site-Specific Antibody-Drug Conjugates Using Click Cycloaddition Chemistry. Bioconjug Chem. 2015 Nov 18;26(11):2249-60. doi: 10.1021/acs.bioconjchem.5b00359.
Ref 33 Antibody-drug conjugates for removing hematopoietic stem cells
Ref 34 A Novel NAMPT Inhibitor-Based Antibody-Drug Conjugate Payload Class for Cancer Therapy. Bioconjug Chem. 2022 Jun 15;33(6):1210-1221.
Ref 35 Introduction to basic information on ADC Anvatabart pactil.
Ref 36 Hiding Payload Inside the IgG Fc Cavity Significantly Enhances the Therapeutic Index of Antibody-Drug Conjugates. J Med Chem. 2023 Jan 12;66(1):1011-1026. doi: 10.1021/acs.jmedchem.2c01812. Epub 2022 Dec 30.
Ref 37 A novel anti-HER2/EGFR bispecific antibody-drug conjugate demonstrates promising antitumor efficacy and overcomes resistance to HER2- or EGFR-targeted ADCs
Ref 38 Conditionally active anti-her2 antibodies, antibody fragments their immunoconjugates and uses thereof; 2021-07-29.
Ref 39 Antibody-Drug Conjugates with Pyrrole-Based KSP Inhibitors as the Payload Class. Angew Chem Int Ed Engl. 2018 Nov 12;57(46):15243-15247. doi: 10.1002/anie.201807619. Epub 2018 Oct 15.
Ref 40 Tetravalent antibody-drug conjugates and uses thereof
Ref 41 Conjugates of antibodies and immune cell engagers
Ref 42 1-(chloromethyl)-2,3-dihydro-1h-benzo[e]indole dimer antibody-drug conjugate compounds, and methods of use and treatment.
Ref 43 Nickel-Catalyzed Antibody Bioconjugation
Ref 44 Selenium antibody conjugates
Ref 45 Leveraging a Dual Variable Domain Immunoglobulin to Create a Site-Specifically Modified Radioimmunoconjugate. Mol Pharm. 2023 Jan 2;20(1):775-782. doi: 10.1021/acs.molpharmaceut.2c00700. Epub 2022 Nov 15.
Ref 46 Antibody-drug conjugates for delivering cytotoxic agents using MATE technology
Ref 47 Synthesis and evaluation of pyrrolobenzodiazepine dimer antibody-drug conjugates with dual -glucuronide and dipeptide triggers. Eur J Med Chem. 2019 Oct 1;179:591-607.
Ref 48 Synthesis and in vitro evaluation of SG3227, a pyrrolobenzodiazepine dimer antibody-drug conjugate payload based on sibiromycin. Bioorg Med Chem Lett. 2017 Mar 1;27(5):1154-1158.
Ref 49 Antibody-drug conjugate comprising modified antibody
Ref 50 Preparation method for antibody-drug conjugate, and application; 2022-11-03.
Ref 51 Uses of antibody-drug conjugates
Ref 52 Antibody compositions comprising Fc mutations and site-specific conjugation properties for use in treating cancer, immunological disorders, and methods thereof
Ref 53 Linkers for use in antibody drug conjugates; 2023-03-16.
Ref 54 Calicheamicin derivatives and antibody drug conjugates thereof
Ref 55 Antibody-Drug Conjugates Used in Breast Cancers. J Oncol. 2021 Jun 24;2021:9927433. doi: 10.1155/2021/9927433. eCollection 2021.
Ref 56 Antibody-drug conjugates of N-haloalkyl substituted camptothecin derivatives
Ref 57 Antibody-drug conjugates of N-alkoxyalkyl substituted camptothecin derivatives
Ref 58 Antibody-drug conjugates of N-azidoalkyl substituted camptothecin derivatives
Ref 59 2'-deoxy-2',2'-difluorocytidine ProTides and antibody-drug conjugates and their preparation and uses
Ref 60 Bifunctional linker compounds, antibody-drug conjugates, and their preparation methods and uses
Ref 61 An auristatin-based antibody-drug conjugate targeting EphA2 in pancreatic cancer treatment
Ref 62 Antibody-drug conjugates of N-oxacycloalkyl substituted camptothecin derivatives
Ref 63 Antibody-drug conjugates, their preparation methods and applications
Ref 64 An Elaborate New Linker System Significantly Enhances the Efficacy of an HER2-Antibody-Drug Conjugate against Refractory HER2-Positive Cancers. Adv Sci (Weinh). 2021 Dec;8(23):e2102414. doi: 10.1002/advs.202102414. Epub 2021 Oct 18.
Ref 65 Antibody-drug conjugate intermediates and preparation methods thereof
Ref 66 Oligosaccharide linker, linker-payload comprising the same and glycan chain-remodeled antibody-drug conjugate, preparation methods and uses thereof
Ref 67 Use of hydroxypropyl-&beta;-cyclodextrin in stabilizing antibody-drug conjugate formulations
Ref 68 Antibody-drug conjugates and production thereof
Ref 69 TLR7 agonists and antibody-drug conjugates thereof
Ref 70 Antibody-drug conjugates and uses thereof
Ref 71 Antibody-drug conjugate precursor and intermediate for synthesis thereof
Ref 72 Coumarin-containing linkers and antibody-drug conjugates comprising the linkers
Ref 73 Development of applicable thiol-linked antibody-drug conjugates with improved stability and therapeutic index. Drug Deliv. 2022 Dec;29(1):754-766.
Ref 74 Synthesis and evaluation of highly releasable and structurally stable antibody-SN-38-conjugates. Drug Deliv. 2021 Dec;28(1):2603-2617.
Ref 75 Antibody-Drug Conjugate Using Ionized Cys-Linker-MMAE as the Potent Payload Shows Optimal Therapeutic Safety. Cancers (Basel). 2020 Mar 21;12(3):744. doi: 10.3390/cancers12030744.
Ref 76 Novel Silyl Ether-Based Acid-Cleavable Antibody-MMAE Conjugates with Appropriate Stability and Efficacy. Cancers (Basel). 2019 Jul 8;11(7):957. doi: 10.3390/cancers11070957.
Ref 77 Development of applicable thiol-linked antibody-drug conjugates with improved stability and therapeutic index. Drug Deliv. 2022 Dec;29(1):754-766. doi: 10.1080/10717544.2022.2039807.
Ref 78 Linker, antibody-drug conjugate including same, and uses thereof
Ref 79 Branched pegylated linker-auristatin to control hydrophobicity for the production of homogeneous minibody-drug conjugate against HER2-positive breast cancer
Ref 80 Anti-HER2 Affibody-Conjugated Photosensitizer for Tumor Targeting Photodynamic Therapy. Mol Pharm. 2020 May 4;17(5):1546-1557. doi: 10.1021/acs.molpharmaceut.9b01247. Epub 2020 Apr 16.
Ref 81 Drug conjugates of imidazoquinoline amine derivatives, compositions and methods thereof
Ref 82 Ligand-drug conjugate of exatecan analogue, preparation method therefor and application thereof; 2020-04-02.
Ref 83 Neodegrader conjugates; 2021-10-07.
Ref 84 Shifting the Antibody-Drug Conjugate Paradigm: A Trastuzumab-Gold-Based Conjugate Demonstrates High Efficacy against Human Epidermal Growth Factor Receptor 2-Positive Breast Cancer Mouse Model
Ref 85 Preparation method for doubly substituted bridge-linked antibody-drug conjugates
Ref 86 Domide molecular glue derivative and use thereof
Ref 87 Computational-aided rational mutation design of pertuzumab to overcome active HER2 mutation S310F through antibody-drug conjugates
Ref 88 Regression of established breast carcinoma xenografts with antibody-directed enzyme prodrug therapy against c-erbB2 p185. Cancer Res. 1994 Oct 1;54(19):5171-7.
Ref 89 Pharmaceutical compositions of anti-HER2 antibody-drug conjugate
Ref 90 Novel masked antibodies
Ref 91 Production of site-specific antibody conjugates using metabolic glycoengineering and novel Fc glycovariants
Ref 92 Targeted delivery of dual payloads of MMAF or MMAE and TLR7 agonists for the treatment of cancer
Ref 93 PEGylated antibody hydroxyl-bearing drug conjugates
Ref 94 Antibody-drug conjugates
Ref 95 Pyrrolobenzodiazepine antibody drug conjugates and methods of use; 2017-04-06.
Ref 96 PROTAC antibody conjugates and methods of use
Ref 97 Pyrrolobenzodiazepines and conjugates thereof; 2015-04-09.
Ref 98 Silvestrol antibody-drug conjugates and methods of use; 2017-12-14.
Ref 99 Antibody-drug conjugates cleavable in a tumor microenvironment
Ref 100 Copper assisted sequence-specific chemical protein conjugation at a single backbone amide
Ref 101 Site-Selective Tyrosine Reaction for Antibody-Cell Conjugation and Targeted Immunotherapy
Ref 102 Design, Synthesis, and Bioevaluation of a Novel Hybrid Molecular Pyrrolobenzodiazepine-Anthracenecarboxyimide as a Payload for Antibody-Drug Conjugate. J Med Chem. 2022 Sep 8;65(17):11679-11702. doi: 10.1021/acs.jmedchem.2c00471. Epub 2022 Aug 18.
Ref 103 Enzymatic glycan remodeling-metal free click (GlycoConnect) provides homogenous antibody-drug conjugates with improved stability and therapeutic index without sequence engineering. MAbs. 2022 Jan-Dec;14(1):2078466.
Ref 104 Transient Inhibition of Trastuzumab-Tumor Binding to Overcome the "Binding-Site Barrier" and Improve the Efficacy of a Trastuzumab-Gelonin Immunotoxin. Mol Cancer Ther. 2022 Oct 7;21(10):1573-1582.
Ref 105 Design and Characterization of Immune-Stimulating Imidazo[4,5-c]quinoline Antibody-Drug Conjugates. Mol Pharm. 2022 Sep 5;19(9):3228-3241.
Ref 106 Targeting HER2-positive breast cancer with trastuzumab-DM1, an antibody-cytotoxic drug conjugate. Cancer Res. 2008 Nov 15;68(22):9280-90.
Ref 107 Biological Evaluation of Maytansinoid-Based Site-Specific Antibody-Drug Conjugate Produced by Fully Chemical Conjugation Approach: AJICAP. Front Biosci (Landmark Ed). 2022 Aug 5;27(8):234.
Ref 108 Design and characterization of homogenous antibody-drug conjugates with a drug-to-antibody ratio of one prepared using an engineered antibody and a dual-maleimide pyrrolobenzodiazepine dimer. MAbs. 2019 Apr;11(3):500-515.
Ref 109 Highly Potent, Anthracycline-based Antibody-Drug Conjugates Generated by Enzymatic, Site-specific Conjugation. Mol Cancer Ther. 2017 May;16(5):879-892.
Ref 110 A new immunochemical strategy for triple-negative breast cancer therapy. Sci Rep. 2021 Jul 21;11(1):14875.
Ref 111 Synthesis and Evaluation of Three Azide-Modified Disaccharide Oxazolines as Enzyme Substrates for Single-Step Fc Glycan-Mediated Antibody-Drug Conjugation. Bioconjug Chem. 2022 Jun 15;33(6):1179-1191.
Ref 112 General and Robust Chemoenzymatic Method for Glycan-Mediated Site-Specific Labeling and Conjugation of Antibodies: Facile Synthesis of Homogeneous Antibody-Drug Conjugates. ACS Chem Biol. 2021 Nov 19;16(11):2502-2514.
Ref 113 The first ADC bearing the ferroptosis inducer RSL3 as a payload with conservation of the fragile electrophilic warhead. Eur J Med Chem. 2022 Dec 15;244:114863.
Ref 114 Design and Synthesis of Tesirine, a Clinical Antibody-Drug Conjugate Pyrrolobenzodiazepine Dimer Payload. ACS Med Chem Lett. 2016 May 24;7(11):983-987.
Ref 115 Introduction to basic information on ADC drug LIN-002.
Ref 116 HER2-targeted DEP SN-38 ADC outperforms in HER2+ human cancer model (ASX announcement); 2023
Ref 117 BN 80245: An E-ring modified camptothecin with potent antiproliferative and topoisomerase I inhibitory activities. Bioorg Med Chem Lett. 1997;7(17):2235-2238.
Ref 118 Fluorescence Imaging of Tumor-Accumulating Antibody-IR700 Conjugates Prior to Near-Infrared Photoimmunotherapy (NIR-PIT) Using a Commercially Available Camera Designed for Indocyanine Green. Mol Pharm. 2021 Mar 1;18(3):1238-1246. doi: 10.1021/acs.molpharmaceut.0c01107. Epub 2021 Jan 27.
Ref 119 Spirea secures more capital to develop nextgeneration ADC cancer therapeutics; 2020
Ref 120 Develop highly specific cell engager constructs with improved function and safety by understanding target-effector cell avidity.
Ref 121 Adcitmer , a new CD56-targeting monomethyl auristatin E-conjugated antibody, is a potential therapeutic approach in Merkel cell carcinoma. Br J Dermatol. 2022 Feb;186(2):295-306. doi: 10.1111/bjd.20770.
Ref 122 Therapeutic Potential of MF-TTZ-MMAE, a Site-Specifically Conjugated Antibody-Drug Conjugate, for the Treatment of HER2-Overexpressing Breast Cancer. Bioconjug Chem. 2022 Feb 16;33(2):418-426. doi: 10.1021/acs.bioconjchem.2c00015. Epub 2022 Feb 1.
Ref 123 Divinylpyrimidine reagents generate antibody-drug conjugates with excellent in vivo efficacy and tolerability. Chem Commun (Camb). 2022 Feb 8;58(12):1962-1965. doi: 10.1039/d1cc06766d.
Ref 124 N-terminal selective conjugation method widens the therapeutic window of antibody-drug conjugates by improving tolerability and stability. MAbs. 2021 Jan-Dec;13(1):1914885. doi: 10.1080/19420862.2021.1914885.
Ref 125 A novel anti-HER2 anthracycline-based antibody-drug conjugate induces adaptive anti-tumor immunity and potentiates PD-1 blockade in breast cancer. J Immunother Cancer. 2019 Jan 21;7(1):16. doi: 10.1186/s40425-018-0464-1.
Ref 126 Non-Genetic Generation of Antibody Conjugates Based on Chemoenzymatic Tyrosine Click Chemistry. Bioconjug Chem. 2021 Oct 20;32(10):2167-2172. doi: 10.1021/acs.bioconjchem.1c00351. Epub 2021 Sep 14.
Ref 127 The preclinical pharmacology of PRO1102, a novel exatecan-based HER2-directed antibody-drug conjugate with robust anti-tumor activity. Cancer Res (2022) 82 (12_Supplement): 1758.
Ref 128 Exatecan Antibody Drug Conjugates Based on a Hydrophilic Polysarcosine Drug-Linker Platform. Pharmaceuticals (Basel). 2021 Mar 9;14(3):247. doi: 10.3390/ph14030247.
Ref 129 Harnessing the power of antibodies to fight bone metastasis. Sci Adv. 2021 Jun 23;7(26):eabf2051. doi: 10.1126/sciadv.abf2051.
Ref 130 Payload diversification: a key step in the development of antibody-drug conjugates. J Hematol Oncol. 2023 Jan 17;16(1):3. doi: 10.1186/s13045-022-01397-y.
Ref 131 CRD5500: A versatile small molecule STING agonist amenable to bioconjugation as an ADC. Cancer Res (2019) 79 (13_Supplement): LB-061.
Ref 132 Trastuzumab-deBouganin Conjugate Overcomes Multiple Mechanisms of T-DM1 Drug Resistance. J Immunother. 2016 Apr;39(3):117-26. doi: 10.1097/CJI.0000000000000115.
Ref 133 N-Myristolytransferase (NMT) inhibitors as novel potent payloads for antibody drug conjugates. Cancer Res (2023) 83 (7_Supplement): 2635.
Ref 134 MI130004, a Novel Antibody-Drug Conjugate Combining Trastuzumab with a Molecule of Marine Origin, Shows Outstanding In Vivo Activity against HER2-Expressing Tumors. Mol Cancer Ther. 2018 Apr;17(4):786-794. doi: 10.1158/1535-7163.MCT-17-0795. Epub 2018 Feb 13.
Ref 135 Internalization of Foldamer-Based DNA Mimics through a Site-Specific Antibody Conjugate to Target HER2-Positive Cancer Cells. Pharmaceuticals (Basel). 2021 Jun 28;14(7):624. doi: 10.3390/ph14070624.
Ref 136 ErbB2 Targeted Epigenetic Modulation: Anti-tumor Efficacy of the ADC Trastuzumab-HDACi ST8176AA1. Front Oncol. 2020 Jan 23;9:1534. doi: 10.3389/fonc.2019.01534.
Ref 137 Site-specific construction of triptolide-based antibody-drug conjugates. Bioorg Med Chem. 2021 Dec 1;51:116497. doi: 10.1016/j.bmc.2021.116497. Epub 2021 Nov 10.
Ref 138 A HER2-targeted antibody-novel DNA topoisomerase I inhibitor conjugate induces durable adaptive antitumor immunity by activating dendritic cells. MAbs. 2023 Jan-Dec;15(1):2220466. doi: 10.1080/19420862.2023.2220466.
Ref 139 Generation of DAR1 Antibody-Drug Conjugates for Ultrapotent Payloads Using Tailored GlycoConnect Technology. Bioconjug Chem. 2023 Mar 15;34(3):538-548. doi: 10.1021/acs.bioconjchem.2c00611. Epub 2023 Mar 1.
Ref 140 Antibody conjugates for targeted delivery of Toll-like receptor 9 agonist to the tumor tissue. PLoS One. 2023 Mar 13;18(3):e0282831. doi: 10.1371/journal.pone.0282831. eCollection 2023.
Ref 141 Antibody-Exatecan Conjugates with a Novel Self-immolative Moiety Overcome Resistance in Colon and Lung Cancer. Cancer Discov. 2023 Apr 3;13(4):950-973. doi: 10.1158/2159-8290.CD-22-1368.
Ref 142 Antibody-PROTAC Conjugates Enable HER2-Dependent Targeted Protein Degradation of BRD4. ACS Chem Biol. 2020 Jun 19;15(6):1306-1312. doi: 10.1021/acschembio.0c00285. Epub 2020 Apr 30.
Ref 143 Antibody-Drug Conjugate that Exhibits Synergistic Cytotoxicity with an Endosome-Disruptive Peptide. ACS Omega. 2019 Jul 31;4(7):12955-12968. doi: 10.1021/acsomega.9b01585. eCollection 2019 Jul 31.
Ref 144 Aptamer-Directed Conjugation of DNA to Therapeutic Antibodies. Bioconjug Chem. 2019 Aug 21;30(8):2127-2135. doi: 10.1021/acs.bioconjchem.9b00363. Epub 2019 Jul 12.
Ref 145 Aryl Sulfate is a Useful Motif for Conjugating and Releasing Phenolic Molecules: Sulfur Fluorine Exchange Click Chemistry Enables Discovery of Ortho-Hydroxy-Protected Aryl Sulfate Linker. Bioconjug Chem. 2019 Jul 17;30(7):1957-1968. doi: 10.1021/acs.bioconjchem.9b00340. Epub 2019 Jun 28.
Ref 146 Antibody-nanoparticle conjugate constructed with trastuzumab and nanoparticle albumin-bound paclitaxel for targeted therapy of human epidermal growth factor receptor?2-positive gastric cancer. Oncol Rep. 2018 Mar;39(3):1396-1404. doi: 10.3892/or.2018.6201. Epub 2018 Jan 9.
Ref 147 Tumor uptake and associated greater efficacy of anti-Her2 immunoliposome does not rely on Her2 expression status: study of a docetaxel-trastuzumab immunoliposome on Her2+ breast cancer model (SKBR3). Anticancer Drugs. 2020 Jun;31(5):463-472. doi: 10.1097/CAD.0000000000000878.
Ref 148 A light-responsive, self-immolative linker for controlled drug delivery via peptide- and protein-drug conjugates. Chem Sci. 2019 Aug 19;10(39):8973-8980. doi: 10.1039/c9sc03016f. eCollection 2019 Oct 21.
Ref 149 Binding protein drug conjugates comprising anthracycline derivatives; 2016-06-30.
Ref 150 Antibody drug conjugates; 2023-07-06.
Ref 151 Antibody-drug conjugates comprising branched linkers and methods related thereto; 2017-06-01.
Ref 152 Pyrrolobenzodiazepines and conjugates thereof; 2013-04-18.
Ref 153 Antitumor compound, and preparation method therefor and use thereof; 2022-04-07.
Ref 154 Camptothecin derivative and ligand-drug conjugate thereof; 2022-04-21.
Ref 155 Camptothecin drug having high-stability hydrophilic connecting unit and conjugate thereof; 2021-12-16.
Ref 156 Hydrophilic Auristatin Glycoside Payload Enables Improved Antibody-Drug Conjugate Efficacy and Biocompatibility. Antibodies (Basel). 2018 Mar 22;7(2):15. doi: 10.3390/antib7020015.
Ref 157 Natural Product Bis-Intercalator Depsipeptides as a New Class of Payloads for Antibody-Drug Conjugates. Bioconjug Chem. 2019 Jan 16;30(1):200-209. doi: 10.1021/acs.bioconjchem.8b00843. Epub 2018 Dec 13.
Ref 158 Impact of cathepsin B-sensitive triggers and hydrophilic linkers on in vitro efficacy of novel site-specific antibody-drug conjugates. Org Biomol Chem. 2018 Mar 14;16(11):1882-1889. doi: 10.1039/c7ob02780j.
Ref 159 Peroxide-cleavable linkers for antibody-drug conjugates. Chem Commun (Camb). 2023 Feb 9;59(13):1841-1844. doi: 10.1039/d2cc06677g.
Ref 160 An antibody-supermolecule conjugate for tumor-specific targeting of tumoricidal methylated -cyclodextrin-threaded polyrotaxanes. J Mater Chem B. 2020 Aug 21;8(31):6975-6987. doi: 10.1039/d0tb00575d. Epub 2020 Jun 23.
Ref 161 A Novel Family of Acid-Cleavable Linker Based on Cyclic Acetal Motifs for the Production of Antibody-Drug Conjugates with High Potency and Selectivity. Bioconjug Chem. 2022 Oct 19;33(10):1860-1866. doi: 10.1021/acs.bioconjchem.2c00314. Epub 2022 Sep 15.
Ref 162 One-Pot Conversion of Free Sialoglycans to Functionalized Glycan Oxazolines and Efficient Synthesis of Homogeneous Antibody-Drug Conjugates through Site-Specific Chemoenzymatic Glycan Remodeling. Bioconjug Chem. 2021 Aug 18;32(8):1888-1897. doi: 10.1021/acs.bioconjchem.1c00314. Epub 2021 Aug 5.
Ref 163 Photoconjugation of an Fc-Specific Peptide Enables Efficient DAR 2 Antibody-Drug Conjugate Formation. Org Lett. 2020 Nov 6;22(21):8419-8423. doi: 10.1021/acs.orglett.0c03049. Epub 2020 Oct 19.
Ref 164 Design and Validation of Linkers for Site-Specific Preparation of Antibody-Drug Conjugates Carrying Multiple Drug Copies Per Cysteine Conjugation Site. Int J Mol Sci. 2020 Sep 19;21(18):6882. doi: 10.3390/ijms21186882.
Ref 165 Divinylsulfonamides enable the construction of homogeneous antibody-drug conjugates. Bioorg Med Chem. 2020 Dec 1;28(23):115793. doi: 10.1016/j.bmc.2020.115793. Epub 2020 Oct 6.
Ref 166 Near-infrared-induced drug release from antibody-drug double conjugates exerts a cytotoxic photo-bystander effect. Bioeng Transl Med. 2022 Aug 21;7(3):e10388. doi: 10.1002/btm2.10388. eCollection 2022 Sep.
Ref 167 Amatoxin-armed therapeutic cell surface binding components designed for tumour therapy.
Ref 168 Amatoxin derivatives.
Ref 169 Antibody-drug-conjugate and its use for the treatment of cancer.
Ref 170 Conjugates comprising self-immolative groups and methods related thereto.
Ref 171 Peptide-containing linkers for antibody-drug conjugates.
Ref 172 Novel antibody-drug conjugates and the use of same in therapy.
Ref 173 Binder-wirkstoff-konjugate (adcs) und binder-prodrug-konjugate (apdcs) mit enzymatisch spaltbaren gruppen.
Ref 174 Pyrrolobenzodiazepines and conjugates thereof.
Ref 175 Antibody-linker-drug conjugate, preparation method therefor, and anticancer drug composition containing same.
Ref 176 Spliceostatin analogs.
Ref 177 Antibody-drug conjugates and related compounds, compositions, and methods.
Ref 178 A novel antibody-KSP inhibitor conjugate improves KSP inhibitor efficacy in vitro and in vivo
Ref 179 Antibody-drug conjugates and their preparation methods and uses
Ref 180 Pyrrolobenzodiazepine-anthraceneimide hybrid molecules and their preparation methods and uses
Ref 181 Anthracycline derivative linker reagents, antibody-drug conjugates and methods
Ref 182 Rational Identification of Novel Antibody-Drug Conjugate with High Bystander Killing Effect against Heterogeneous Tumors
Ref 183 A DXd/TLR7-Agonist Dual-Conjugate Anti-HER2 ADC Exerts Robust Antitumor Activity Through Tumor Cell Killing and Immune Activation
Ref 184 Trastuzumab-MMAU Antibody-Auristatin Conjugates: Valine-Glucoserine Linker with Stabilized Maleimide Conjugation Improves In Vivo Efficacy and Tolerability
Ref 185 Synthesis and evaluation of antibody-drug conjugates with high drug-to-antibody ratio using dimaleimide-DM1 as a linker- payload
Ref 186 Discovery and Evaluation of TLR-Targeted Immune Agonists
Ref 187 Exo-Cleavable Linkers: Enhanced Stability and Therapeutic Efficacy in Antibody-Drug Conjugates
Ref 188 Disulfide re-bridging reagents for single-payload antibody-drug conjugates
Ref 189 Potent antitumor activity of anti-HER2 antibody-topoisomerase I inhibitor conjugate based on self-immolative dendritic dimeric-linker
Ref 190 Enhancing the bystander effect of antibody-drug conjugate by using a novel caspase-3 cleavable peptide linker to overcome tumor heterogeneity
Ref 191 Phenyldivinylsulfonamides for the construction of antibody-drug conjugates with controlled four payloads
Ref 192 Generation of a Novel SORT1&times;HER2 Bispecific Antibody-Drug Conjugate Targeting HER2-Low-Expression Tumor
Ref 193 Structure-Activity Relationships of Bis-Intercalating Peptides and Their Application as Antibody-Drug Conjugate Payloads
Ref 194 Biological Evaluation of Antibody-Drug Conjugates Produced by Tag-Free Lipoate Ligase A Modification
Ref 195 Synthesis and evaluation of homocamptothecin antibody-drug conjugates for cancer treatment
Ref 196 Discovery and Optimization of a STING Agonist Platform for Application in Antibody Drug Conjugates
Ref 197 Antibody-Vincristine Conjugates as Potent Anticancer Therapeutic Agents
Ref 198 Generation and structure-activity relationships of novel imidazo-thienopyridine based TLR7 agonists: application as payloads for immunostimulatory antibody drug-conjugates
Ref 199 Antibody-Proteolysis Targeting Chimera Conjugate Enables Selective Degradation of Receptor-Interacting Serine/Threonine-Protein Kinase 2 in HER2+ Cell Lines
Ref 200 Design and Evaluation of Phosphonamidate-Linked Exatecan Constructs for Highly Loaded, Stable, and Efficacious Antibody-Drug Conjugates
Ref 201 Synthesis and biological evaluation of novel quaternary ammonium antibody drug conjugates based on camptothecin derivatives
Ref 202 Affinity-Directed Site-Specific Protein Labeling and Its Application to Antibody-Drug Conjugates
Ref 203 AJICAP-M: Traceless Affinity Peptide Mediated Conjugation Technology for Site-Selective Antibody-Drug Conjugate Synthesis
Ref 204 Tuneable thiol exchange linkers for traceless drug release applications in prodrugs and ADCs
Ref 205 NIR-II aza-BODIPY Platform for the Development of a Fluorescent Antibody Drug Conjugate
Ref 206 Design, synthesis and biological evaluation of camptothecin analogue FL118 as a payload for antibody-drug conjugates in targeted cancer therapy
Ref 207 Sonodynamic Therapy for HER2+ Breast Cancer with Iodinated Heptamethine Cyanine-Trastuzumab Conjugate
Ref 208 Synthesis and Evaluation of a Cathepsin B-Recognizing Trifunctional Chelating Agent to Improve Tumor Retention of Radioimmunoconjugates
Ref 209 Design and Optimization of Selectivity-Tunable Toll-like Receptor 7/8 Agonists as Novel Antibody-Drug Conjugate Payloads
Ref 210 Targeted delivery of alcohol-containing payloads with antibody-drug conjugates
Ref 211 Site-selective antibody-lipid conjugates for surface functionalization of red blood cells and targeted drug delivery
Ref 212 A Novel Dual-Payload ADC for the Treatment of HER2+ Breast and Colon Cancer
Ref 213 Novel Quaternary Ammonium Salt-Linked STING Agonist Antibody-Drug Conjugate: Synergistic Activation of Tumor Immunity with Mitigated Off-Target Toxicity
Ref 214 ValCitGlyPro-dexamethasone antibody conjugates selectively suppress the activation of human monocytes
Ref 215 Linker and Conjugation Site Synergy in Antibody-Drug Conjugates: Impacts on Biological Activity
Ref 216 PK/PD of Positively Charged ADC in Mice
Ref 217 Positron Emission Tomography and Optical Imaging to Monitor Bioorthogonal Diels-Alder Click Chemistry of Trastuzumab with a Porphyrin
Ref 218 A novel DNA sequence-selective, guanine mono-alkylating ADC payload suitable for solid tumour treatment
Ref 219 Effective synthesis, development and application of a highly fluorescent cyanine dye for antibody conjugation and microscopy imaging
Ref 220 Antibody-drug conjugates
Ref 221 A drug conjugate and its preparation method and application
Ref 222 Splicing modulator antibody-drug conjugates and methods of use
Ref 223 An antibody-drug conjugate and its uses
Ref 224 Allenamide linkers for antibody-drug conjugates
Ref 225 Conjugation reagents and conjugates thereof
Ref 226 Drug-antibody conjugates
Ref 227 Novel linkers for antibody-drug conjugates and related compounds, compositions, and methods of use
Ref 228 Immunoconjugates targeting HER2
Ref 229 An antibody-drug conjugate, its preparation method and applications
Ref 230 Antibody-drug complexes containing hemiasterlin derivatives
Ref 231 Antibody drug conjugates with enzymatically cleavable groups
Ref 232 An antibody-drug conjugate and its uses
Ref 233 Antibody-irinotecan conjugates
Ref 234 Linkers containing o-phthalaldehyde and their use in preparing antibody-drug conjugates
Ref 235 Non-linear self-immolative linkers and conjugates thereof
Ref 236 Peptide-containing linkers for antibody-drug conjugates
Ref 237 Antibody-drug conjugate
Ref 238 Oligosaccharide linker, linker-payload comprising the same and glycan chain-remodeled antibody-drug conjugate, preparation methods and uses thereof
Ref 239 Antibody drug conjugate comprising NMT inhibitor and its use
Ref 240 Multi-payload antibody-drug conjugates and their preparation methods and uses
Ref 241 Glyco-engineered antibody-drug conjugates comprising an oxime linker
Ref 242 Aminobenzazepine compounds, immunoconjugates, and uses thereof
Ref 243 DDX5 protein-binding camptothecin derivatives and prodrugs thereof
Ref 244 Preparation method and application of antibody drug conjugate
Ref 245 Organic cytotoxin oligomers and uses thereof as a payload in antibody-drug conjugates
Ref 246 Benzoselenophene compounds, pharmaceutical compositions containing them and antibody-drug conjugates
Ref 247 Pyrrolobenzodiazepine antibody conjugates
Ref 248 Drug conjugates and uses thereof
Ref 249 Anticipate-drug zygotes, pharmacological compositions and Uses
Ref 250 Anti-HER2 antibody-drug conjugate
Ref 251 Anti-ErbB2 antibody-drug conjugate and composition thereof, preparation method therefor, and use thereof
Ref 252 Hexacyclic topoisomerase inhibitors having cytotoxic activity on cancer cells
Ref 253 Antibody drug conjugate
Ref 254 Antibody-drug complexes containing hemiasterlin derivatives
Ref 255 Deuterated camptothecin derivatives and antibody-drug conjugates thereof
Ref 256 Antibody-drug conjugates
Ref 257 Heterocyclic acyl hydrazone linkers, methods and uses thereof
Ref 258 Antibody-drug conjugates
Ref 259 Antibody-multidrug conjugate
Ref 260 Deuterated camptothecin derivatives and their antibody-drug conjugates
Ref 261 Antibody-drug conjugates based on gold compounds
Ref 262 Rapid-release antibody-drug conjugates
Ref 263 Camptothecin derivatives for ADC preparation
Ref 264 Acetal-based cleavable linkers
Ref 265 Compositions and methods for reducing off-target toxicity of antibody drug conjugates
Ref 266 Compositions comprising antibody-duocarmycin drug conjugates
Ref 267 Hydrophilic tetrazine-functionalized payloads for preparing targeted conjugates
Ref 268 Stabilized trioxacarcin antibody drug conjugates and uses thereof
Ref 269 Uses of antibody-drug conjugates
Ref 270 Exatecan derivatives, linker-payloads and conjugates thereof
Ref 271 Antibody-multidrug conjugate
Ref 272 Antibody-drug conjugate binding to human PTK7 and method for preparation and use thereof
Ref 273 Linker-drug conjugates, their preparation methods and applications
Ref 274 Antibody-drug conjugates and uses thereof
Ref 275 Anti-HER2 antibody-drug conjugate
Ref 276 Oxazaphosphorine antibody drug conjugates and methods of use
Ref 277 Isoindolinone-glutarimide antibody conjugates, and uses thereof
Ref 278 Pharmaceuticals containing antibody-drug complexes containing hemiasterin derivatives
Ref 279 Peptide linkers containing glycosides for antibody-drug conjugates
Ref 280 Sulfonyl maleimide-based linkers and corresponding conjugates
Ref 281 Antibody-drug conjugates
Ref 282 Thienobenzodiazepine immunoconjugates and uses thereof
Ref 283 Design and Evaluation of ZD06519, a Novel Camptothecin Payload for Antibody Drug Conjugates
Ref 284 Azobenzene-Based Linker Strategy for Selective Activation of Antibody-Drug Conjugates
Ref 285 Antibody-drug conjugate
Ref 286 Evaluation of Potency and Specificity of Cryptophycin-Loaded Antibody-Drug Conjugates
Ref 287 Novel PIKK inhibitor antibody-drug conjugates: Synthesis and anti-tumor activity. Bioorg Med Chem Lett. 2019 Apr 1;29(7):943-947. doi: 10.1016/j.bmcl.2019.01.009. Epub 2019 Jan 11.
Ref 288 Design, Synthesis, and Biochemical Evaluation of Alpha-Amanitin Derivatives Containing Analogs of the trans-Hydroxyproline Residue for Potential Use in Antibody-Drug Conjugates. Chemistry. 2021 Jul 16;27(40):10282-10292. doi: 10.1002/chem.202101373. Epub 2021 Jun 18.
Ref 289 Tag-free, specific conjugation of glycosylated IgG1 antibodies using microbial transglutaminase. RSC Adv. 2022 Nov 22;12(52):33510-33515. doi: 10.1039/d2ra05630e. eCollection 2022 Nov 22.
Ref 290 Antibody-drug conjugates with dual payloads for combating breast tumor heterogeneity and drug resistance. Nat Commun. 2021 Jun 10;12(1):3528.
Ref 291 Breast cancer targeted/ therapeutic with double and triple fusion Immunotoxins. J Steroid Biochem Mol Biol. 2020 Jun;200:105651. doi: 10.1016/j.jsbmb.2020.105651. Epub 2020 Mar 5.
Ref 292 Improved antibody-payload conjugates (APCs) prepared by site-specific conjugation utilizing genetic code expansion
Ref 293 Site-Selective Antibody Conjugation with Dibromopyrazines
Ref 294 Cyclopentadiene as a Multifunctional Reagent for Normal- and Inverse-Electron Demand Diels-Alder Bioconjugation. Bioconjug Chem. 2022 Sep 21;33(9):1609-1619.
Ref 295 Synthesis of site-specific Fab-drug conjugates using ADP-ribosyl cyclases
Ref 296 Bifunctional cytotoxic agents containing the CTI pharmacophore
Ref 297 Antibody and antibody fragments site-specific conjugation using new Q-tag substrate of bacterial transglutaminase
Ref 298 Chemical Tagging of Bioactive Amides by Cooperative Catalysis: Applications in the Syntheses of Drug Conjugates
Ref 299 New shielded antibody
Ref 300 A Recognition Tag of Human Origin for Bioorthogonal Generation of Antibody-Drug Conjugates using Microbial Biotin Ligase
Ref 301 Methods for preparing protein-small-molecule drug conjugates and applications thereof
Ref 302 Comparison of HER2-targeted affibody conjugates loaded with auristatin- and maytansine-derived drugs. J Control Release. 2023 Mar;355:515-527. doi: 10.1016/j.jconrel.2023.02.005. Epub 2023 Feb 14.
Ref 303 Pathological complete remission of relapsed tumor by photo-activating antibody-mimetic drug conjugate treatment. Cancer Sci. 2022 Dec;113(12):4350-4362.
Ref 304 Sihuan pharmaceutical holdings group annual presentation; 2020
Ref 305 Introduction to basic information on ADC drug xl-250.
Ref 306 Introduction to basic information on ADC drug Anti-HER2 antibody-drug conjugate(XDCExplorer)
Ref 307 YB1 pharmaceutical company product pipeline
Ref 308 Introduction to basic information on biparatopic HER2 x HER2 antibody drug conjugate(Regeneron Pharmaceuticals).
Ref 309 Introduction to basic information on ADC drug Anti-HER2-4AP ADC(Catalent Biologics)
Ref 310 Introduction to basic information on anti-HER2 antibody drug conjugates(NBE-Therapeutics).
Ref 311 Introduction to basic information on anti-HER2 antibody-drug conjugate(Mersana Therapeutics/Genentech).
Ref 312 Introduction to basic information on ADC drug Mabion-HER2 ADC
Ref 313 Intocell biotechnology company product pipeline
Ref 314 Introduction to basic information on ADC drug TE-1218.
Ref 315 Introduction to basic information on ADC drug TE-1112.
Ref 316 A second-generation antibody-drug conjugate to treat HER2-positive breast cancer. Lancet. 2023 Jan 14;401(10371):80-81. doi: 10.1016/S0140-6736(22)02534-X. Epub 2022 Dec 7.
Ref 317 Introduction to basic information on ADC drug Chloromethylbenz-Indoline Dimer Antibody Drug conjugate
Ref 318 Bioasis and wuxi biologics announce initial strategic collaboration for the development and manufacturing of xB3-001, the companys lead investigational candidate to treat brain cancer; 2018
Ref 319 Antibody fragment drug-conjugates (FDCs)-application of ANT-043 and ANT-045 in solid tumors. Cancer Res (2021) 81 (13_Supplement): 909.
Ref 320 ADC review: basic information about ABGN-110.
Ref 321 Antibody drug conjugate using CTAT linker technology shows superior efficacy in xenograft trial; 2015
Ref 322 Introduction to basic information on humanized anti-HER2 mab-maytansine conjugate(Anhui Anke Biotechnology/Wuxi Pharmatech).
Ref 323 An investigational next generation ADC (DAN-311) is highly effective in HER2-low breast cancer models. Cancer Res (2022) 82 (4_Supplement): P2-13-09.
Ref 324 A JAB-X1800/JAB-BX400 introduction by Jacobio Pharmaceuticals.
Ref 325 Quadira Biosciences AG company product pipeline
Ref 326 Introduction to basic information on ADC drug Antibody-drug conjugate (Scripps).
Ref 327 Trident-type linkers and applications thereof
Ref 328 Study of ZV0203 in Patients With HER2-Positive Advanced Solid Tumors; NCT05423977.
Ref 329 Fudan-zhangjiang bio-pharmaceutic company indicative announcement
Ref 330 Novel development strategies and challenges for anti-Her2 antibody-drug conjugates. Antib Ther. 2022 Jan 27;5(1):18-29. doi: 10.1093/abt/tbac001.
Ref 331 A comparison of the activity, lysosomal stability, and efficacy of legumain-cleavable and cathepsin-cleavable ADC linkers
Ref 332 Comparison of quaternary ammonium-based linkers for antibody-drug conjugates based on camptothecin derivatives
Ref 333 Tumor cell-directed STING agonist antibody-drug conjugates induce type III interferons and anti-tumor innate immune responses
Ref 334 Development and application of an in vitro assay to assess target-independent B-cell activation by targeted TLR7 immune agonists
Ref 335 Discovery of a novel antibody-drug conjugate linker-payload with a distinct killing mechanism via prolonged unfolded protein response activation
Ref 336 Prodrugs of topoisomerase I inhibitor for ADC conjugations and methods of use thereof
Ref 337 Protein-drug conjugates comprising camptothecin analogs and methods of use thereof
Ref 338 Antibody drug conjugates comprising dolastatin derivatives
Ref 339 Antibody-drug complexes
Ref 340 Camptothecin analogs conjugated to glutamine residues in proteins and their uses
Ref 341 Antibody-drug conjugates and uses thereof
Ref 342 Combination of antibody-drug conjugate and CDK9 inhibitor
Ref 343 Engineered antibody constant regions for site-specific conjugation and methods and uses therefor
Ref 344 Prodrugs of topoisomerase I inhibitor for ADC conjugations and methods of use thereof
Ref 345 Therapy for drug-resistant cancer by administration of anti-HER2 antibody/drug conjugate
Ref 346 Antibody-drug conjugates comprising antibodies against human TROP2 and uses thereof
Ref 347 Bromomethylpyrazine-based drug conjugates and ADCs
Ref 348 Linkers for antibody-drug conjugates and uses thereof
Ref 349 Use of an antibody-drug conjugate, pharmaceutical composition and pharmaceutical combination
Ref 350 PEGylated antibody hydroxyl-bearing drug conjugates
Ref 351 Hydrophilic linkers for antibody-drug conjugates
Ref 352 Antibody drug conjugate loaded with binary toxins and its application
Ref 353 Combination of antibody-drug conjugate and Aurora B inhibitor
Ref 354 Combination of antibody-drug conjugate with anti-SIRP&alpha; antibody