Antibody Information

General Information of This Antibody

Antibody ID	ANI0RBUVD
Antibody Name	Thio anti-HER2 hu7C2 LC K149C HC L177C
Antibody Type	Monoclonal antibody (mAb)
Antibody Subtype	Humanized IgG1-kappa
Antigen Name	Receptor tyrosine-protein kinase erbB-2 (ERBB2)	Antigen Info

Each Antibody-drug Conjugate Related to This Antibody

Full Information of The Activity Data of The ADC(s) Related to This Antibody

WO2017059289A1 ADC-113 [Investigative]

ADC Info

Discovered Using Cell Line-derived Xenograft Model

Click To Hide/Show 1 Activity Data Related to This Level

Experiment 1 Reporting the Activity Date of This ADC					[1]
Efficacy Data	Tumor Growth Inhibition value (TGI)	≈ 0.00% (Day 14)	Positive CD22 expression (CD22+++/++)
Method Description	Inoculate 150 mice with WSU-DLCL2 cells at 3 million cells/mouse suspended in HBSS/matrigel, in the thoracic mammary fat pad at a volume of 0.2 ml. When tumors have reached a mean tumor volume of 100-250 mm³, they will be grouped out into 10 groups of 8-10 mice each. A single treatment will be administered intravenously (8.3 mg/kg) via the tail vein on Day 0. Click to Show/Hide
In Vivo Model	WSU-DLCL2 CDX model
In Vitro Model	Diffuse large B-cell lymphoma	WSU-DLCL2 cells		CVCL_1902

References

Ref 1	Pyrrolobenzodiazepine antibody drug conjugates and methods of use; 2017-04-06.

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