Antibody-drug Conjugate Information

General Information of This Antibody-drug Conjugate (ADC)
ADC ID
DRG0GUSXO
ADC Name
WO2017214024A1 ADC-106
Synonyms
WO2017214024A1 ADC-106
   Click to Show/Hide
Organization
Genentech, Inc.
Drug Status
Investigative
Indication
In total 1 Indication(s)
Breast cancer [ICD11:2C60-2C65]
Investigative
Drug-to-Antibody Ratio
1.97
Antibody Name
Thio hu Anti-HER2 7C2 HC A140C
  Antibody Info 
Antigen Name
Receptor tyrosine-protein kinase erbB-2 (ERBB2)
  Antigen Info 
Payload Name
Undisclosed
Linker Name
WO2017214024A1_ADC-106 linker
General Information of The Activity Data Related to This ADC
Discovered Using Cell Line-derived Xenograft Model
Click To Hide/Show 2 Activity Data Related to This Level
Standard Type Value Units Cell Line Disease Model
Tumor Growth Inhibition value (TGI) 
≈ 28.32
%
BJAB cells
Burkitt lymphoma
Tumor Growth Inhibition value (TGI) 
≈ 48.87
%
BJAB cells
Burkitt lymphoma
Full List of Activity Data of This Antibody-drug Conjugate
Discovered Using Cell Line-derived Xenograft Model
Click To Hide/Show 2 Activity Data Related to This Level
Experiment 1 Reporting the Activity Date of This ADC [1]
Efficacy Data Tumor Growth Inhibition value (TGI) ≈ 28.32% (Day 17) Moderate CD22 expression (CD22++)
Method Description
Inoculate 150 mice with BJAB cells at 3 million cells/mouse suspended in HBSS/matrigel, in the thoracic mammary fat pad at a volume of 0.2 ml. When tumors have reached a mean tumor volume of 100-250 mm3, they will be grouped out into 10 groups of 8-10 mice each. A single treatment will be administered intravenously (3 mg/kg) via the tail vein on Day 0.

   Click to Show/Hide
In Vivo Model BJAB CDX model
In Vitro Model Burkitt lymphoma BJAB cells CVCL_5711
Experiment 2 Reporting the Activity Date of This ADC [1]
Efficacy Data Tumor Growth Inhibition value (TGI) ≈ 48.87% (Day 17) Moderate CD22 expression (CD22++)
Method Description
Inoculate 150 mice with BJAB cells at 3 million cells/mouse suspended in HBSS/matrigel, in the thoracic mammary fat pad at a volume of 0.2 ml. When tumors have reached a mean tumor volume of 100-250 mm3, they will be grouped out into 10 groups of 8-10 mice each. A single treatment will be administered intravenously (10 mg/kg) via the tail vein on Day 0.

   Click to Show/Hide
In Vivo Model BJAB CDX model
In Vitro Model Burkitt lymphoma BJAB cells CVCL_5711
References
Ref 1 Silvestrol antibody-drug conjugates and methods of use; 2017-12-14.

If you find any error in data or bug in web service, please kindly report it to Dr. Shen et al.