Antibody-drug Conjugate Information
General Information of This Antibody-drug Conjugate (ADC)
| ADC ID |
DRG0IJVEW
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| ADC Name |
Trastuzumab-L1-TL
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| Synonyms |
Tra-L1-TL
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| Drug Status |
Investigative
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| Indication |
In total 1 Indication(s)
Breast cancer [ICD11:2C60-2C65]
Investigative
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| Drug-to-Antibody Ratio |
2.75
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| Structure |
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| Antibody Name |
Trastuzumab
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Antibody Info | ||||
| Antigen Name |
Receptor tyrosine-protein kinase erbB-2 (ERBB2)
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Antigen Info | ||||
| Payload Name |
Triptolide
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Payload Info | ||||
| Therapeutic Target |
Nuclear factor NF-kappa-B p105 subunit (NFKB1)
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Target Info | ||||
| Linker Name |
BVP-PEG3-carbamate
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Linker Info | ||||
| Conjugate Type |
All the linker-drugs contain a BVP group for the site-specific conjugation to the disulfides of antibody by re-bridging approach.
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| Combination Type |
L1-TL
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