General Information of This Antibody-drug Conjugate (ADC)
ADC ID
DRG0HORED
ADC Name
T-D265C-NH2-Pro-amanitin
Synonyms
T-D265C NH2-Pro-amanitin
   Click to Show/Hide
Drug Status
Investigative
Indication
In total 1 Indication(s)
Breast cancer [ICD11:2C60-2C65]
Investigative
Drug-to-Antibody Ratio
2
Structure
Antibody Name
Trastuzumab D265C
 Antibody Info 
Antigen Name
Receptor tyrosine-protein kinase erbB-2 (ERBB2)
 Antigen Info 
Payload Name
NH2-Pro-dideoxy-alpha-amanitin
 Payload Info 
Therapeutic Target
DNA-directed RNA polymerase II subunit RPB2 (POLR2B); DNA-directed RNA polymerase III subunit RPC7 (POLR3G)
 Target Info 
Linker Name
Mc-Val-Ala-PABC
 Linker Info 
Conjugate Type
Site-specific conjugated of maleimidocaproyl with two D265C free thiol in heavy chains, Michael addition reaction.

If you find any error in data or bug in web service, please kindly report it to Dr. Shen et al.