Antibody-drug Conjugate Information
General Information of This Antibody-drug Conjugate (ADC)
| ADC ID |
DRG0EFLMW
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| ADC Name |
T-D265C-OH-Pro-amanitin
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| Synonyms |
T-D265C OH-Pro-amanitin
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| Drug Status |
Investigative
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| Indication |
In total 1 Indication(s)
Breast cancer [ICD11:2C60-2C65]
Investigative
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| Drug-to-Antibody Ratio |
2
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| Structure |
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| Antibody Name |
Trastuzumab D265C
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Antibody Info | ||||
| Antigen Name |
Receptor tyrosine-protein kinase erbB-2 (ERBB2)
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Antigen Info | ||||
| Payload Name |
OH-Pro-dideoxy-alpha-amanitin
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Payload Info | ||||
| Therapeutic Target |
DNA-directed RNA polymerase II subunit RPB2 (POLR2B); DNA-directed RNA polymerase III subunit RPC7 (POLR3G)
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Target Info | ||||
| Linker Name |
Mc-Val-Ala-PABC
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Linker Info | ||||
| Conjugate Type |
Site-specific conjugated of maleimidocaproyl with two D265C free thiol in heavy chains, Michael addition reaction.
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