Antibody Information
General Information of This Antibody
| Antibody ID | ANI0BFSVD |
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| Antibody Name | Modified ZHER2:2891 protein (ZHER2) |
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| Antibody Type | Fusion protein (FP) |
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| Antigen Name | Receptor tyrosine-protein kinase erbB-2 (ERBB2) |
Antigen Info | ||||
Each Antibody-drug Conjugate Related to This Antibody
Full Information of The Activity Data of The ADC(s) Related to This Antibody
Pyro-Linker-ZHER2 [Investigative]
Discovered Using Cell Line-derived Xenograft Model
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Tumor Growth Inhibition value (TGI) | ≈ 100.00% (Day 19) | High HER2 expression (HER2 +++) | ||
| Method Description |
BALB/c nude mice bearing HER2-high expression NCI-N87 tumors received iv injection of 20 nmol/mouse of Pyro-Linker-ZHER2, Pyro-Linker-OH, Pyro, or PBS buffer only and then irradiated with 180 J/cm2 light 4 h (for groups of PyroLinker-ZHER2 and PBS buffer only) postinjection.
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| In Vivo Model | NCI-N87 CDX model | ||||
| In Vitro Model | Gastric tubular adenocarcinoma | NCI-N87 cells | CVCL_1603 | ||
Revealed Based on the Cell Line Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal Inhibitory Concentration (IC50) |
12.50 nM
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High HER2 expression (HER2 +++) | ||
| Method Description |
Dark toxicity was measured without light illumination, and a HER2 receptor blocking experiment was carried out by preincubation of the cells with free ZHER2:2891 affibody (10.0 M) for 4 h before the addition of Pyro, Pyro-Linker-OH, or Pyro-Linker-ZHER2.
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| In Vitro Model | Invasive breast carcinoma | BT-474 cells | CVCL_0179 | ||
| Experiment 2 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal Inhibitory Concentration (IC50) |
23.00 nM
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High HER2 expression (HER2 +++) | ||
| Method Description |
Dark toxicity was measured without light illumination, and a HER2 receptor blocking experiment was carried out by preincubation of the cells with free ZHER2:2891 affibody (10.0 M) for 4 h before the addition of Pyro, Pyro-Linker-OH, or Pyro-Linker-ZHER2.
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| In Vitro Model | Gastric tubular adenocarcinoma | NCI-N87 cells | CVCL_1603 | ||
| Experiment 3 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal Inhibitory Concentration (IC50) | > 1000 nM | Low HER2 expression (HER2 -) | ||
| Method Description |
Dark toxicity was measured without light illumination, and a HER2 receptor blocking experiment was carried out by preincubation of the cells with free ZHER2:2891 affibody (10.0 M) for 4 h before the addition of Pyro, Pyro-Linker-OH, or Pyro-Linker-ZHER2.
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| In Vitro Model | Invasive breast carcinoma | MCF-7 cells | CVCL_0031 | ||
| Experiment 4 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal Inhibitory Concentration (IC50) | > 1000 nM | Low HER2 expression (HER2 -) | ||
| Method Description |
Dark toxicity was measured without light illumination, and a HER2 receptor blocking experiment was carried out by preincubation of the cells with free ZHER2:2891 affibody (10.0 M) for 4 h before the addition of Pyro, Pyro-Linker-OH, or Pyro-Linker-ZHER2.
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| In Vitro Model | Prostate carcinoma | PC-3 cells | CVCL_0035 | ||
| Experiment 5 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal Inhibitory Concentration (IC50) | > 1000 nM | High HER2 expression (HER2 +++) | ||
| Method Description |
Dark toxicity was measured without light illumination, and a HER2 receptor blocking experiment was carried out by preincubation of the cells with free ZHER2:2891 affibody (10.0 M) for 4 h before the addition of Pyro, Pyro-Linker-OH, or Pyro-Linker-ZHER2.
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| In Vitro Model | Gastric tubular adenocarcinoma | NCI-N87 cells (blocking) | CVCL_1603 | ||
| Experiment 6 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal Inhibitory Concentration (IC50) | > 1000 nM | Low HER2 expression (HER2 -) | ||
| Method Description |
Dark toxicity was measured without light illumination, and a HER2 receptor blocking experiment was carried out by preincubation of the cells with free ZHER2:2891 affibody (10.0 M) for 4 h before the addition of Pyro, Pyro-Linker-OH, or Pyro-Linker-ZHER2.
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| In Vitro Model | Prostate carcinoma | PC-3 cells (blocking) | CVCL_0035 | ||
References
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