Antibody Information

General Information of This Antibody

Antibody ID	ANI0HMZTU
Antibody Name	ZHER2:342-Cupid-His
Antibody Type	Monoclonal antibody (mAb)
Antigen Name	Receptor tyrosine-protein kinase erbB-2 (ERBB2)	Antigen Info

Each Antibody-drug Conjugate Related to This Antibody

Full Information of The Activity Data of The ADC(s) Related to This Antibody

ZHER2:342-Cupid-His-Ax-SiPc [Investigative]

ADC Info

Discovered Using Cell Line-derived Xenograft Model

Click To Hide/Show 2 Activity Data Related to This Level

Experiment 1 Reporting the Activity Date of This ADC					[1]
Efficacy Data	Tumor Growth Inhibition value (TGI)	82.40% (Day 21)	Low HER2 expression (HER2+)
Method Description	The Kadcyla (the anti- Her2 ADC) group were administered at 300 g.
In Vivo Model	KPL- 4 cell line xenograft model
In Vitro Model	Breast inflammatory carcinoma	KPL-4 cells		CVCL_5310
Experiment 2 Reporting the Activity Date of This ADC					[1]
Efficacy Data	Tumor Growth Inhibition value (TGI)	93.40% (Day 21)	Low HER2 expression (HER2+)
Method Description	The ZHER2:342-Cupid-His-Ax-SiPc group were administered at 150 g.
In Vivo Model	KPL- 4 cell line xenograft model
In Vitro Model	Breast inflammatory carcinoma	KPL-4 cells		CVCL_5310

References

Ref 1	Pathological complete remission of relapsed tumor by photo-activating antibody-mimetic drug conjugate treatment. Cancer Sci. 2022 Dec;113(12):4350-4362.

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