Antigen Information

General Information of This Antigen
Antigen ID
TAR0GLSWQ
Antigen Name
CD276 antigen (CD276)
Gene Name
CD276
Gene ID
80381
Synonym
B7H3; PSEC0249; UNQ309; PRO352; 4Ig-B7-H3;B7 homolog 3;Costimulatory molecule;CD_antigen=CD276
Sequence
MLRRRGSPGMGVHVGAALGALWFCLTGALEVQVPEDPVVALVGTDATLCCSFSPEPGFSL
AQLNLIWQLTDTKQLVHSFAEGQDQGSAYANRTALFPDLLAQGNASLRLQRVRVADEGSF
TCFVSIRDFGSAAVSLQVAAPYSKPSMTLEPNKDLRPGDTVTITCSSYQGYPEAEVFWQD
GQGVPLTGNVTTSQMANEQGLFDVHSILRVVLGANGTYSCLVRNPVLQQDAHSSVTITPQ
RSPTGAVEVQVPEDPVVALVGTDATLRCSFSPEPGFSLAQLNLIWQLTDTKQLVHSFTEG
RDQGSAYANRTALFPDLLAQGNASLRLQRVRVADEGSFTCFVSIRDFGSAAVSLQVAAPY
SKPSMTLEPNKDLRPGDTVTITCSSYRGYPEAEVFWQDGQGVPLTGNVTTSQMANEQGLF
DVHSVLRVVLGANGTYSCLVRNPVLQQDAHGSVTITGQPMTFPPEALWVTVGLSVCLIAL
LVALAFVCWRKIKQSCEEENAGAEDQDGEGEGSKTALQPLKHSDSKEDDGQEIA

    Click to Show/Hide
Family
HIV-1 env protein family
Function
May participate in the regulation of T-cell-mediated immune response. May play a protective role in tumor cells by inhibiting natural-killer mediated cell lysis as well as a role of marker for detection of neuroblastoma cells. May be involved in the development of acute and chronic transplant rejection and in the regulation of lymphocytic activity at mucosal surfaces. Could also play a key role in providing the placenta and fetus with a suitable immunological environment throughout pregnancy. Both isoform 1 and isoform 2 appear to be redundant in their ability to modulate CD4 T-cell responses. Isoform 2 is shown to enhance the induction of cytotoxic T-cells and selectively stimulates interferon gamma production in the presence of T-cell receptor signaling.

    Click to Show/Hide
Uniprot Entry
CD276_HUMAN
HGNC ID
HGNC:19137
KEGG ID
hsa:80381
Each Antibody-drug Conjuate AND It's Component Related to This Antigen
Full List of The ADC Related to This Antigen
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
1D1-01-ADC-Tb1-1
1D1-01-ADC-Tb1-1 payload
Undisclosed
1D1-01-ADC-Tb1-1 linker
 [1]
 ADC Info 
1D1-01-ADC-Tb1-10
1D1-01-ADC-Tb1-10 payload
Undisclosed
1D1-01-ADC-Tb1-10 linker
 [1]
 ADC Info 
1D1-01-ADC-Tb1-11
1D1-01-ADC-Tb1-11 payload
Undisclosed
1D1-01-ADC-Tb1-11 linker
 [1]
 ADC Info 
1D1-01-ADC-Tb1-12
1D1-01-ADC-Tb1-12 payload
Undisclosed
1D1-01-ADC-Tb1-12 linker
 [1]
 ADC Info 
1D1-01-ADC-Tb1-13
1D1-01-ADC-Tb1-13 payload
Undisclosed
1D1-01-ADC-Tb1-13 linker
 [1]
 ADC Info 
1D1-01-ADC-Tb1-14
1D1-01-ADC-Tb1-14 payload
Undisclosed
1D1-01-ADC-Tb1-14 linker
 [1]
 ADC Info 
1D1-01-ADC-Tb1-15
1D1-01-ADC-Tb1-15 payload
Undisclosed
1D1-01-ADC-Tb1-15 linker
 [1]
 ADC Info 
1D1-01-ADC-Tb1-16
1D1-01-ADC-Tb1-16 payload
Undisclosed
1D1-01-ADC-Tb1-16 linker
 [1]
 ADC Info 
1D1-01-ADC-Tb1-17
1D1-01-ADC-Tb1-17 payload
Undisclosed
1D1-01-ADC-Tb1-17 linker
 [1]
 ADC Info 
1D1-01-ADC-Tb1-18
1D1-01-ADC-Tb1-18 payload
Undisclosed
1D1-01-ADC-Tb1-18 linker
 [1]
 ADC Info 
1D1-01-ADC-Tb1-19
1D1-01-ADC-Tb1-19 payload
Undisclosed
1D1-01-ADC-Tb1-19 linker
 [1]
 ADC Info 
1D1-01-ADC-Tb1-2
1D1-01-ADC-Tb1-2 payload
Undisclosed
1D1-01-ADC-Tb1-2 linker
 [1]
 ADC Info 
1D1-01-ADC-Tb1-20
1D1-01-ADC-Tb1-20 payload
Undisclosed
1D1-01-ADC-Tb1-20 linker
 [1]
 ADC Info 
1D1-01-ADC-Tb1-21
1D1-01-ADC-Tb1-21 payload
Undisclosed
1D1-01-ADC-Tb1-21 linker
 [1]
 ADC Info 
1D1-01-ADC-Tb1-22
1D1-01-ADC-Tb1-22 payload
Undisclosed
1D1-01-ADC-Tb1-22 linker
 [1]
 ADC Info 
1D1-01-ADC-Tb1-23
1D1-01-ADC-Tb1-23 payload
Undisclosed
1D1-01-ADC-Tb1-23 linker
 [1]
 ADC Info 
1D1-01-ADC-Tb1-24
1D1-01-ADC-Tb1-24 payload
Undisclosed
1D1-01-ADC-Tb1-24 linker
 [1]
 ADC Info 
1D1-01-ADC-Tb1-25
1D1-01-ADC-Tb1-25 payload
Undisclosed
1D1-01-ADC-Tb1-25 linker
 [1]
 ADC Info 
1D1-01-ADC-Tb1-26
1D1-01-ADC-Tb1-26 payload
Undisclosed
1D1-01-ADC-Tb1-26 linker
 [1]
 ADC Info 
1D1-01-ADC-Tb1-3
1D1-01-ADC-Tb1-3 payload
Undisclosed
1D1-01-ADC-Tb1-3 linker
 [1]
 ADC Info 
1D1-01-ADC-Tb1-4
1D1-01-ADC-Tb1-4 payload
Undisclosed
1D1-01-ADC-Tb1-4 linker
 [1]
 ADC Info 
1D1-01-ADC-Tb1-5
1D1-01-ADC-Tb1-5 payload
Undisclosed
1D1-01-ADC-Tb1-5 linker
 [1]
 ADC Info 
1D1-01-ADC-Tb1-6
1D1-01-ADC-Tb1-6 payload
Undisclosed
1D1-01-ADC-Tb1-6 linker
 [1]
 ADC Info 
1D1-01-ADC-Tb1-7
1D1-01-ADC-Tb1-7 payload
Undisclosed
1D1-01-ADC-Tb1-7 linker
 [1]
 ADC Info 
1D1-01-ADC-Tb1-8
1D1-01-ADC-Tb1-8 payload
Undisclosed
1D1-01-ADC-Tb1-8 linker
 [1]
 ADC Info 
1D1-01-ADC-Tb1-9
1D1-01-ADC-Tb1-9 payload
Undisclosed
1D1-01-ADC-Tb1-9 linker
 [1]
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
WO2020063676A1 ADC-25
WO2020063676A1_ADC-25 payload
Undisclosed
WO2020063676A1_ADC-25 linker
 [2]
 ADC Info 
WO2020063676A1 ADC-26
WO2020063676A1_ADC-26 payload
Undisclosed
WO2020063676A1_ADC-26 linker
 [2]
 ADC Info 
WO2020063676A1 ADC-27
WO2020063676A1_ADC-27 payload
Undisclosed
WO2020063676A1_ADC-27 linker
 [2]
 ADC Info 
WO2020063676A1 ADC-28
WO2020063676A1_ADC-28 payload
Undisclosed
WO2020063676A1_ADC-28 linker
 [2]
 ADC Info 
WO2020063676A1 ADC-29
WO2020063676A1_ADC-29 payload
Undisclosed
WO2020063676A1_ADC-29 linker
 [2]
 ADC Info 
WO2020063676A1 ADC-30
WO2020063676A1_ADC-30 payload
Undisclosed
WO2020063676A1_ADC-30 linker
 [2]
 ADC Info 
WO2020063676A1 ADC-31
WO2020063676A1_ADC-31 payload
Undisclosed
WO2020063676A1_ADC-31 linker
 [2]
Anti-B7H3 mAb 2E3-02
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
B7H3-ADC-01
B7H3-ADC-01 payload
Undisclosed
B7H3-ADC-01 linker
 [1]
 ADC Info 
B7H3-ADC-02
B7H3-ADC-02 payload
Undisclosed
B7H3-ADC-02 linker
 [1]
 ADC Info 
B7H3-ADC-03
B7H3-ADC-03 payload
Undisclosed
B7H3-ADC-03 linker
 [1]
 ADC Info 
B7H3-ADC-04 (DAR8)
B7H3-ADC-04 payload
Undisclosed
B7H3-ADC-04 linker
 [1]
 ADC Info 
B7H3-ADC-05 (DAR4)
B7H3-ADC-05(DAR8) payload
Undisclosed
B7H3-ADC-05(DAR4) linker
 [1]
 ADC Info 
B7H3-ADC-05 (DAR8)
B7H3-ADC-05(DAR8) payload
Undisclosed
B7H3-ADC-05(DAR8) linker
 [1]
 ADC Info 
B7H3-ADC-06 (DAR8)
B7H3-ADC-06 payload
Undisclosed
B7H3-ADC-06 linker
 [1]
 ADC Info 
B7H3-ADC-07 (DAR2)
B7H3-ADC-07(DAR2) payload
Undisclosed
B7H3-ADC-07(DAR2) linker
 [1]
 ADC Info 
B7H3-ADC-07 (DAR4)
B7H3-ADC-07(DAR4) payload
Undisclosed
B7H3-ADC-07(DAR4) linker
 [1]
 ADC Info 
B7H3-ADC-07 (DAR6)
B7H3-ADC-07(DAR6) payload
Undisclosed
B7H3-ADC-07(DAR6) linker
 [1]
 ADC Info 
B7H3-ADC-07 (DAR8)
B7H3-ADC-07(DAR8) payload
Undisclosed
B7H3-ADC-07(DAR8) linker
 [1]
 ADC Info 
B7H3-ADC-08 (DAR4)
B7H3-ADC-08(DAR4) payload
Undisclosed
B7H3-ADC-08(DAR4) linker
 [1]
 ADC Info 
B7H3-ADC-08 (DAR8)
B7H3-ADC-08(DAR8) payload
Undisclosed
B7H3-ADC-08(DAR8) linker
 [1]
 ADC Info 
B7H3-ADC-09 (DAR8)
B7H3-ADC-09 payload
Undisclosed
B7H3-ADC-09 linker
 [1]
 ADC Info 
B7H3-ADC-10 (DAR8)
B7H3-ADC-10 payload
Undisclosed
B7H3-ADC-10 linker
 [1]
 ADC Info 
B7H3-ADC-11 (DAR8)
B7H3-ADC-11 payload
Undisclosed
B7H3-ADC-11 linker
 [1]
 ADC Info 
B7H3-ADC-12 (DAR8)
B7H3-ADC-12 payload
Undisclosed
B7H3-ADC-12 linker
 [1]
 ADC Info 
B7H3-ADC-13 (DAR8)
B7H3-ADC-13 payload
Undisclosed
B7H3-ADC-13 linker
 [1]
 ADC Info 
B7H3-ADC-14 (DAR8)
B7H3-ADC-14 payload
Undisclosed
B7H3-ADC-14 linker
 [1]
 ADC Info 
B7H3-ADC-15 (DAR4)
B7H3-ADC-15(DAR4) payload
Undisclosed
B7H3-ADC-15(DAR4) linker
 [1]
 ADC Info 
B7H3-ADC-15 (DAR8)
B7H3-ADC-15(DAR8) payload
Undisclosed
B7H3-ADC-15(DAR8) linker
 [1]
 ADC Info 
B7H3-ADC-16 (DAR8)
B7H3-ADC-16 payload
Undisclosed
B7H3-ADC-16 linker
 [1]
 ADC Info 
B7H3-ADC-17
B7H3-ADC-17 payload
Undisclosed
B7H3-ADC-17 linker
 [1]
 ADC Info 
B7H3-ADC-18 (DAR8)
B7H3-ADC-18 payload
Undisclosed
B7H3-ADC-18 linker
 [1]
 ADC Info 
B7H3-ADC-19 (DAR8)
B7H3-ADC-19 payload
Undisclosed
B7H3-ADC-19 linker
 [1]
 ADC Info 
B7H3-ADC-20 (DAR8)
B7H3-ADC-20 payload
Undisclosed
B7H3-ADC-20 linker
 [1]
 ADC Info 
B7H3-ADC-22 (DAR8)
B7H3-ADC-22 payload
Undisclosed
B7H3-ADC-22 linker
 [1]
 ADC Info 
B7H3-ADC-23 (DAR8)
B7H3-ADC-23 payload
Undisclosed
B7H3-ADC-23 linker
 [1]
 ADC Info 
B7H3-ADC-24 (DAR8)
B7H3-ADC-24 payload
Undisclosed
B7H3-ADC-24 linker
 [1]
 ADC Info 
B7H3-ADC-25 (DAR8)
B7H3-ADC-25 payload
Undisclosed
B7H3-ADC-25 linker
 [1]
 ADC Info 
B7H3-ADC-27 (DAR8)
B7H3-ADC-27 payload
Undisclosed
B7H3-ADC-27 linker
 [1]
 ADC Info 
B7H3-ADC-28 (DAR8)
B7H3-ADC-28 payload
Undisclosed
B7H3-ADC-28 linker
 [1]
 ADC Info 
B7H3-ADC-32 (DAR8)
B7H3-ADC-32 payload
Undisclosed
B7H3-ADC-32 linker
 [1]
 ADC Info 
B7H3-ADC-33 (DAR4)
B7H3-ADC-33(DAR4) payload
Undisclosed
B7H3-ADC-33(DAR4) linker
 [1]
 ADC Info 
B7H3-ADC-33 (DAR8)
B7H3-ADC-33(DAR8) payload
Undisclosed
B7H3-ADC-33(DAR8) linker
 [1]
Anti-CD276 mAb h1702DS
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
WO2020063673A1 ADC-1
WO2020063673A1_ADC-1 payload
Undisclosed
WO2020063673A1_ADC-1 linker
 [3]
 ADC Info 
WO2020063673A1 ADC-2
WO2020063673A1_ADC-2 payload
Undisclosed
WO2020063673A1_ADC-2 linker
 [3]
 ADC Info 
WO2020063673A1 ADC-3
WO2020063673A1_ADC-3 payload
Undisclosed
WO2020063673A1_ADC-3 linker
 [3]
 ADC Info 
WO2020063673A1 ADC-4
WO2020063673A1_ADC-4 payload
Undisclosed
WO2020063673A1_ADC-4 linker
 [3]
 ADC Info 
WO2020063673A1 ADC-5
WO2020063673A1_ADC-5 payload
Undisclosed
WO2020063673A1_ADC-5 linker
 [3]
 ADC Info 
WO2020063673A1 ADC-6
WO2020063673A1_ADC-6 payload
Undisclosed
WO2020063673A1_ADC-6 linker
 [3]
 ADC Info 
WO2020063673A1 ADC-7
WO2020063673A1_ADC-7 payload
Undisclosed
WO2020063673A1_ADC-7 linker
 [3]
 ADC Info 
WO2020063673A1 ADC-8
WO2020063673A1_ADC-8 payload
Undisclosed
WO2020063673A1_ADC-8 linker
 [3]
Anti-CD276 mAb m276-SL
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
M276-SL-PBD
PBD dimer
Human Deoxyribonucleic acid (hDNA)
Mc-Val-Ala
 [4]
Anti-human CD276 mAb
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
B7H3-EC1
NAMPT inhibitor 4
Nicotinamide phosphoribosyltransferase (NAMPT)
Maleimido-caproyl
 [5]
 ADC Info 
B7H3-EC2
NAMPT inhibitor 6
Nicotinamide phosphoribosyltransferase (NAMPT)
Maleimido-caproyl
 [5]
 ADC Info 
B7H3-EC3 DAR4.1
NAMPT inhibitor 4
Nicotinamide phosphoribosyltransferase (NAMPT)
Mc-Val-Ala
 [5]
 ADC Info 
B7H3-EC3 DAR7.8
NAMPT inhibitor 4
Nicotinamide phosphoribosyltransferase (NAMPT)
Mc-Val-Ala
 [5]
 ADC Info 
B7H3-EC4
NAMPT inhibitor 5
Nicotinamide phosphoribosyltransferase (NAMPT)
Open-chain glycine maleimide
 [5]
 ADC Info 
B7H3-EC5
NAMPT inhibitor 6
Nicotinamide phosphoribosyltransferase (NAMPT)
Open-chain glycine maleimide-PEG
 [5]
 ADC Info 
CN109069633A ADC-1
CN109069633A ADC-1 payload
Undisclosed
CN109069633A ADC-1 linker
 [6]
 ADC Info 
CN109069633A ADC-2
CN109069633A ADC-2 payload
Undisclosed
CN109069633A ADC-2 linker
 [6]
 ADC Info 
CN109069633A ADC-3
CN109069633A ADC-3 payload
Undisclosed
CN109069633A ADC-3 linker
 [6]
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
B7H3-ADC-21 (DAR2)
B7H3-ADC-21(DAR2) payload
Undisclosed
B7H3-ADC-21(DAR2) linker
 [1]
 ADC Info 
B7H3-ADC-21 (DAR6)
B7H3-ADC-21(DAR6) payload
Undisclosed
B7H3-ADC-21(DAR6) linker
 [1]
 ADC Info 
B7H3-ADC-21 (DAR8)
B7H3-ADC-21(DAR8) payload
Undisclosed
B7H3-ADC-21(DAR8) linker
 [1]
 ADC Info 
B7H3-C1-ADC-05 (DAR4)
B7H3-C1-ADC-05(DAR4) payload
Undisclosed
B7H3-C1-ADC-05(DAR4) linker
 [1]
 ADC Info 
B7H3-C1-ADC-07 (DAR4)
B7H3-C1-ADC-07(DAR4) payload
Undisclosed
B7H3-C1-ADC-07(DAR4) linker
 [1]
 ADC Info 
B7H3-C1-ADC-08 (DAR4)
B7H3-C1-ADC-08(DAR4) payload
Undisclosed
B7H3-C1-ADC-08(DAR4) linker
 [1]
 ADC Info 
B7H3-C1-ADC-21 (DAR4)
B7H3-C1-ADC-21(DAR4) payload
Undisclosed
B7H3-C1-ADC-21(DAR4) linker
 [1]
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
chAb11-CZ
chAb11-CZ payload
Undisclosed
chAb11-CZ linker
 [7]
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
chAb13-CZ
chAb13-CZ payload
Undisclosed
chAb13-CZ linker
 [7]
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
chAb14-CZ
chAb14-CZ payload
Undisclosed
chAb14-CZ linker
 [7]
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
chAb16-CZ
chAb16-CZ payload
Undisclosed
chAb16-CZ linker
 [7]
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
chAb18-CZ
chAb18-CZ payload
Undisclosed
chAb18-CZ linker
 [7]
chAb2 (chimra IgG1)
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
chAb2-CZ
chAb2-CZ payload
Undisclosed
chAb2-CZ linker
 [7]
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
chAb3-CZ
chAb3-CZ payload
Undisclosed
chAb3-CZ linker
 [7]
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
chAb4-CZ
chAb4-CZ payload
Undisclosed
chAb4-CZ linker
 [7]
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
chAb6-CZ
chAb6-CZ payload
Undisclosed
chAb6-CZ linker
 [7]
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
chmAb-A B7-H3-ADC
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 [8]
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
chmAb-B B7-H3-ADC
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 [8]
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
chmAb-C B7-H3-ADC
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 [8]
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
chmAb-D B7-H3-ADC
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 [8]
Enoblituzumab
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
Enoblituzumab-ADC-24-1
Enoblituzumab-ADC-24-1 payload
Undisclosed
Enoblituzumab-ADC-24-1 linker
 [2]
 ADC Info 
Enoblituzumab-ADC-24-10
Enoblituzumab-ADC-24-10 payload
Undisclosed
Enoblituzumab-ADC-24-10 linker
 [2]
 ADC Info 
Enoblituzumab-ADC-24-11
Enoblituzumab-ADC-24-11 payload
Undisclosed
Enoblituzumab-ADC-24-11 linker
 [2]
 ADC Info 
Enoblituzumab-ADC-24-12
Enoblituzumab-ADC-24-12 payload
Undisclosed
Enoblituzumab-ADC-24-12 linker
 [2]
 ADC Info 
Enoblituzumab-ADC-24-13
Enoblituzumab-ADC-24-13 payload
Undisclosed
Enoblituzumab-ADC-24-13 linker
 [2]
 ADC Info 
Enoblituzumab-ADC-24-2
Enoblituzumab-ADC-24-2 payload
Undisclosed
Enoblituzumab-ADC-24-2 linker
 [2]
 ADC Info 
Enoblituzumab-ADC-24-3
Enoblituzumab-ADC-24-3 payload
Undisclosed
Enoblituzumab-ADC-24-3 linker
 [2]
 ADC Info 
Enoblituzumab-ADC-24-4
Enoblituzumab-ADC-24-4 payload
Undisclosed
Enoblituzumab-ADC-24-4 linker
 [2]
 ADC Info 
Enoblituzumab-ADC-24-5
Enoblituzumab-ADC-24-5 payload
Undisclosed
Enoblituzumab-ADC-24-5 linker
 [2]
 ADC Info 
Enoblituzumab-ADC-24-6
Enoblituzumab-ADC-24-6 payload
Undisclosed
Enoblituzumab-ADC-24-6 linker
 [2]
 ADC Info 
Enoblituzumab-ADC-24-7
Enoblituzumab-ADC-24-7 payload
Undisclosed
Enoblituzumab-ADC-24-7 linker
 [2]
 ADC Info 
Enoblituzumab-ADC-24-8
Enoblituzumab-ADC-24-8 payload
Undisclosed
Enoblituzumab-ADC-24-8 linker
 [2]
 ADC Info 
Enoblituzumab-ADC-24-9
Enoblituzumab-ADC-24-9 payload
Undisclosed
Enoblituzumab-ADC-24-9 linker
 [2]
 ADC Info 
Enoblituzumab-ADC-Tb1-1
Enoblituzumab-ADC-Tb1-1 payload
Undisclosed
Enoblituzumab-ADC-Tb1-1 linker
 [1]
 ADC Info 
Enoblituzumab-ADC-Tb1-10
Enoblituzumab-ADC-Tb1-10 payload
Undisclosed
Enoblituzumab-ADC-Tb1-10 linker
 [1]
 ADC Info 
Enoblituzumab-ADC-Tb1-11
Enoblituzumab-ADC-Tb1-11 payload
Undisclosed
Enoblituzumab-ADC-Tb1-11 linker
 [1]
 ADC Info 
Enoblituzumab-ADC-Tb1-12
Enoblituzumab-ADC-Tb1-12 payload
Undisclosed
Enoblituzumab-ADC-Tb1-12 linker
 [1]
 ADC Info 
Enoblituzumab-ADC-Tb1-13
Enoblituzumab-ADC-Tb1-13 payload
Undisclosed
Enoblituzumab-ADC-Tb1-13 linker
 [1]
 ADC Info 
Enoblituzumab-ADC-Tb1-14
Enoblituzumab-ADC-Tb1-14 payload
Undisclosed
Enoblituzumab-ADC-Tb1-14 linker
 [1]
 ADC Info 
Enoblituzumab-ADC-Tb1-15
Enoblituzumab-ADC-Tb1-15 payload
Undisclosed
Enoblituzumab-ADC-Tb1-15 linker
 [1]
 ADC Info 
Enoblituzumab-ADC-Tb1-16
Enoblituzumab-ADC-Tb1-16 payload
Undisclosed
Enoblituzumab-ADC-Tb1-16 linker
 [1]
 ADC Info 
Enoblituzumab-ADC-Tb1-17
Enoblituzumab-ADC-Tb1-17 payload
Undisclosed
Enoblituzumab-ADC-Tb1-17 linker
 [1]
 ADC Info 
Enoblituzumab-ADC-Tb1-18
Enoblituzumab-ADC-Tb1-18 payload
Undisclosed
Enoblituzumab-ADC-Tb1-18 linker
 [1]
 ADC Info 
Enoblituzumab-ADC-Tb1-19
Enoblituzumab-ADC-Tb1-19 payload
Undisclosed
Enoblituzumab-ADC-Tb1-19 linker
 [1]
 ADC Info 
Enoblituzumab-ADC-Tb1-2
Enoblituzumab-ADC-Tb1-2 payload
Undisclosed
Enoblituzumab-ADC-Tb1-2 linker
 [1]
 ADC Info 
Enoblituzumab-ADC-Tb1-20
Enoblituzumab-ADC-Tb1-20 payload
Undisclosed
Enoblituzumab-ADC-Tb1-20 linker
 [1]
 ADC Info 
Enoblituzumab-ADC-Tb1-21
Enoblituzumab-ADC-Tb1-21 payload
Undisclosed
Enoblituzumab-ADC-Tb1-21 linker
 [1]
 ADC Info 
Enoblituzumab-ADC-Tb1-22
Enoblituzumab-ADC-Tb1-22 payload
Undisclosed
Enoblituzumab-ADC-Tb1-22 linker
 [1]
 ADC Info 
Enoblituzumab-ADC-Tb1-23
Enoblituzumab-ADC-Tb1-23 payload
Undisclosed
Enoblituzumab-ADC-Tb1-23 linker
 [1]
 ADC Info 
Enoblituzumab-ADC-Tb1-24
Enoblituzumab-ADC-Tb1-24 payload
Undisclosed
Enoblituzumab-ADC-Tb1-24 linker
 [1]
 ADC Info 
Enoblituzumab-ADC-Tb1-25
Enoblituzumab-ADC-Tb1-25 payload
Undisclosed
Enoblituzumab-ADC-Tb1-25 linker
 [1]
 ADC Info 
Enoblituzumab-ADC-Tb1-26
Enoblituzumab-ADC-Tb1-26 payload
Undisclosed
Enoblituzumab-ADC-Tb1-26 linker
 [1]
 ADC Info 
Enoblituzumab-ADC-Tb1-3
Enoblituzumab-ADC-Tb1-3 payload
Undisclosed
Enoblituzumab-ADC-Tb1-3 linker
 [1]
 ADC Info 
Enoblituzumab-ADC-Tb1-4
Enoblituzumab-ADC-Tb1-4 payload
Undisclosed
Enoblituzumab-ADC-Tb1-4 linker
 [1]
 ADC Info 
Enoblituzumab-ADC-Tb1-5
Enoblituzumab-ADC-Tb1-5 payload
Undisclosed
Enoblituzumab-ADC-Tb1-5 linker
 [1]
 ADC Info 
Enoblituzumab-ADC-Tb1-6
Enoblituzumab-ADC-Tb1-6 payload
Undisclosed
Enoblituzumab-ADC-Tb1-6 linker
 [1]
 ADC Info 
Enoblituzumab-ADC-Tb1-7
Enoblituzumab-ADC-Tb1-7 payload
Undisclosed
Enoblituzumab-ADC-Tb1-7 linker
 [1]
 ADC Info 
Enoblituzumab-ADC-Tb1-8
Enoblituzumab-ADC-Tb1-8 payload
Undisclosed
Enoblituzumab-ADC-Tb1-8 linker
 [1]
 ADC Info 
Enoblituzumab-ADC-Tb1-9
Enoblituzumab-ADC-Tb1-9 payload
Undisclosed
Enoblituzumab-ADC-Tb1-9 linker
 [1]
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
hmAb-C-DUBA
seco-DUBA
Human Deoxyribonucleic acid (hDNA)
Mal-PEG2-Val-Cit-PABA-Cyclization Spacer
 [8]
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
huAb13v1-AAA
huAb13v1-AAA payload
Undisclosed
huAb13v1-AAA linker
 [7]
 ADC Info 
huAb13v1-AAD
huAb13v1-AAD payload
Undisclosed
huAb13v1-AAD linker
 [7]
 ADC Info 
huAb13v1-CZ
huAb13v1-CZ payload
Undisclosed
huAb13v1-CZ linker
 [7]
 ADC Info 
huAb13v1-KZ
huAb13v1-KZ payload
Undisclosed
huAb13v1-KZ linker
 [7]
 ADC Info 
huAb13v1-LB
huAb13v1-LB payload
Undisclosed
huAb13v1-LB linker
 [7]
 ADC Info 
huAb13v1-SE
huAb13v1-SE payload
Undisclosed
huAb13v1-SE linker
 [7]
 ADC Info 
huAb13v1-SR
huAb13v1-SR payload
Undisclosed
huAb13v1-SR linker
 [7]
 ADC Info 
huAb13v1-TV
huAb13v1-TV payload
Undisclosed
huAb13v1-TV linker
 [7]
 ADC Info 
huAb13v1-TX
huAb13v1-TX payload
Undisclosed
huAb13v1-TX linker
 [7]
 ADC Info 
huAb13v1-TX E2
huAb13v1-TX E2 payload
Undisclosed
huAb13v1-TX E2 linker
 [7]
 ADC Info 
huAb13v1-WD
huAb13v1-WD payload
Undisclosed
huAb13v1-WD linker
 [7]
 ADC Info 
huAb13v1-WD E2
huAb13v1-WD E2 payload
Undisclosed
huAb13v1-WD E2 linker
 [7]
 ADC Info 
huAb13v1-XW
huAb13v1-XW payload
Undisclosed
huAb13v1-XW linker
 [7]
 ADC Info 
huAb13v1-YG
huAb13v1-YG payload
Undisclosed
huAb13v1-YG linker
 [7]
 ADC Info 
huAb13v1-ZT
huAb13v1-ZT payload
Undisclosed
huAb13v1-ZT linker
 [7]
 ADC Info 
huAb13v1-ZZ
huAb13v1-ZZ payload
Undisclosed
huAb13v1-ZZ linker
 [7]
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
huAb18v1-CZ
huAb18v1-CZ payload
Undisclosed
huAb18v1-CZ linker
 [7]
huAb18v10
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
huAb18v10-CZ
huAb18v10-CZ payload
Undisclosed
huAb18v10-CZ linker
 [7]
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
huAb18v2-CZ
huAb18v2-CZ payload
Undisclosed
huAb18v2-CZ linker
 [7]
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
huAb18v3-CZ
huAb18v3-CZ payload
Undisclosed
huAb18v3-CZ linker
 [7]
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
huAb18v4-CZ
huAb18v4-CZ payload
Undisclosed
huAb18v4-CZ linker
 [7]
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
huAb18v5-CZ
huAb18v5-CZ payload
Undisclosed
huAb18v5-CZ linker
 [7]
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
huAb18v6-CZ
huAb18v6-CZ payload
Undisclosed
huAb18v6-CZ linker
 [7]
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
huAb18v7-CZ
huAb18v7-CZ payload
Undisclosed
huAb18v7-CZ linker
 [7]
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
huAb18v8-CZ
huAb18v8-CZ payload
Undisclosed
huAb18v8-CZ linker
 [7]
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
huAb18v9-CZ
huAb18v9-CZ payload
Undisclosed
huAb18v9-CZ linker
 [7]
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
huAb3v1-CZ
huAb3v1-CZ payload
Undisclosed
huAb3v1-CZ linker
 [7]
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
huAb3v2-CZ
huAb3v2-CZ payload
Undisclosed
huAb3v2-CZ linker
 [7]
huAb3v2.2
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
huAb3v2.2-CZ
huAb3v2.2-CZ payload
Undisclosed
huAb3v2.2-CZ linker
 [7]
huAb3v2.3
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
huAb3v2.3-CZ
huAb3v2.3-CZ payload
Undisclosed
huAb3v2.3-CZ linker
 [7]
huAb3v2.5
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
huAb3v2.5-AAA
huAb3v2.5-AAA payload
Undisclosed
huAb3v2.5-AAA linker
 [7]
 ADC Info 
huAb3v2.5-AAD
huAb3v2.5-AAD payload
Undisclosed
huAb3v2.5-AAD linker
 [7]
 ADC Info 
huAb3v2.5-CZ
huAb3v2.5-CZ payload
Undisclosed
huAb3v2.5-CZ linker
 [7]
 ADC Info 
huAb3v2.5-KZ
huAb3v2.5-KZ payload
Undisclosed
huAb3v2.5-KZ linker
 [7]
 ADC Info 
huAb3v2.5-LB
huAb3v2.5-LB payload
Undisclosed
huAb3v2.5-LB linker
 [7]
 ADC Info 
huAb3v2.5-SE
huAb3v2.5-SE payload
Undisclosed
huAb3v2.5-SE linker
 [7]
 ADC Info 
huAb3v2.5-SR
huAb3v2.5-SR payload
Undisclosed
huAb3v2.5-SR linker
 [7]
 ADC Info 
huAb3v2.5-TV
huAb3v2.5-TV payload
Undisclosed
huAb3v2.5-TV linker
 [7]
 ADC Info 
huAb3v2.5-TX
huAb3v2.5-TX payload
Undisclosed
huAb3v2.5-TX linker
 [7]
 ADC Info 
huAb3v2.5-WD
huAb3v2.5-WD payload
Undisclosed
huAb3v2.5-WD linker
 [7]
 ADC Info 
huAb3v2.5-XW
huAb3v2.5-XW payload
Undisclosed
huAb3v2.5-XW linker
 [7]
 ADC Info 
huAb3v2.5-YG
huAb3v2.5-YG payload
Undisclosed
huAb3v2.5-YG linker
 [7]
 ADC Info 
huAb3v2.5-YY
huAb3v2.5-YY payload
Undisclosed
huAb3v2.5-YY linker
 [7]
 ADC Info 
huAb3v2.5-ZT
huAb3v2.5-ZT payload
Undisclosed
huAb3v2.5-ZT linker
 [7]
 ADC Info 
huAb3v2.5-ZZ
huAb3v2.5-ZZ payload
Undisclosed
huAb3v2.5-ZZ linker
 [7]
huAb3v2.6
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
huAb3v2.6-AAA
huAb3v2.6-AAA payload
Undisclosed
huAb3v2.6-AAA linker
 [7]
 ADC Info 
huAb3v2.6-AAD
huAb3v2.6-AAD payload
Undisclosed
huAb3v2.6-AAD linker
 [7]
 ADC Info 
huAb3v2.6-CZ
huAb3v2.6-CZ payload
Undisclosed
huAb3v2.6-CZ linker
 [7]
 ADC Info 
huAb3v2.6-KZ
huAb3v2.6-KZ payload
Undisclosed
huAb3v2.6-KZ linker
 [7]
 ADC Info 
huAb3v2.6-LB
huAb3v2.6-LB payload
Undisclosed
huAb3v2.6-LB linker
 [7]
 ADC Info 
huAb3v2.6-SE
huAb3v2.6-SE payload
Undisclosed
huAb3v2.6-SE linker
 [7]
 ADC Info 
huAb3v2.6-SR
huAb3v2.6-SR payload
Undisclosed
huAb3v2.6-SR linker
 [7]
 ADC Info 
huAb3v2.6-TV
huAb3v2.6-TV payload
Undisclosed
huAb3v2.6-TV linker
 [7]
 ADC Info 
huAb3v2.6-TX
huAb3v2.6-TX payload
Undisclosed
huAb3v2.6-TX linker
 [7]
 ADC Info 
huAb3v2.6-WD
huAb3v2.6-WD payload
Undisclosed
huAb3v2.6-WD linker
 [7]
 ADC Info 
huAb3v2.6-XW
huAb3v2.6-XW payload
Undisclosed
huAb3v2.6-XW linker
 [7]
 ADC Info 
huAb3v2.6-YG
huAb3v2.6-YG payload
Undisclosed
huAb3v2.6-YG linker
 [7]
 ADC Info 
huAb3v2.6-YY
huAb3v2.6-YY payload
Undisclosed
huAb3v2.6-YY linker
 [7]
 ADC Info 
huAb3v2.6-ZT
huAb3v2.6-ZT payload
Undisclosed
huAb3v2.6-ZT linker
 [7]
 ADC Info 
huAb3v2.6-ZZ
huAb3v2.6-ZZ payload
Undisclosed
huAb3v2.6-ZZ linker
 [7]
huAb3v2.8
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
huAb3v2.8-CZ
huAb3v2.8-CZ payload
Undisclosed
huAb3v2.8-CZ linker
 [7]
huAb3v2.9
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
huAb3v2.9-CZ
huAb3v2.9-CZ payload
Undisclosed
huAb3v2.9-CZ linker
 [7]
 ADC Info 
huAb3v2.9-TX
huAb3v2.9-TX payload
Undisclosed
huAb3v2.9-TX linker
 [7]
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
huAb3v3-CZ
huAb3v3-CZ payload
Undisclosed
huAb3v3-CZ linker
 [7]
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
huAb3v4-CZ
huAb3v4-CZ payload
Undisclosed
huAb3v4-CZ linker
 [7]
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
huAb3v5-CZ
huAb3v5-CZ payload
Undisclosed
huAb3v5-CZ linker
 [7]
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
huAb3v6-CZ
huAb3v6-CZ payload
Undisclosed
huAb3v6-CZ linker
 [7]
Ifinatamab
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
Ifinatamab deruxtecan
DX-8951 derivative (DXd)
DNA topoisomerase 1 (TOP1)
Mc-Gly-Gly-Phe-Gly
 [9]
Mirzotamab
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
Mirzotamab clezutoclax
Clezutoclax
Bcl-2-like protein 1 (BCL2L1)
Valine-alanine (cleavable linker)
 [10]
 ADC Info 
Mirzotamab-ADC-Tb1-1
Mirzotamab-ADC-Tb1-1 payload
Undisclosed
Mirzotamab-ADC-Tb1-1 linker
 [1]
 ADC Info 
Mirzotamab-ADC-Tb1-10
Mirzotamab-ADC-Tb1-10 payload
Undisclosed
Mirzotamab-ADC-Tb1-10 linker
 [1]
 ADC Info 
Mirzotamab-ADC-Tb1-11
Mirzotamab-ADC-Tb1-11 payload
Undisclosed
Mirzotamab-ADC-Tb1-11 linker
 [1]
 ADC Info 
Mirzotamab-ADC-Tb1-12
Mirzotamab-ADC-Tb1-12 payload
Undisclosed
Mirzotamab-ADC-Tb1-12 linker
 [1]
 ADC Info 
Mirzotamab-ADC-Tb1-13
Mirzotamab-ADC-Tb1-13 payload
Undisclosed
Mirzotamab-ADC-Tb1-13 linker
 [1]
 ADC Info 
Mirzotamab-ADC-Tb1-14
Mirzotamab-ADC-Tb1-14 payload
Undisclosed
Mirzotamab-ADC-Tb1-14 linker
 [1]
 ADC Info 
Mirzotamab-ADC-Tb1-15
Mirzotamab-ADC-Tb1-15 payload
Undisclosed
Mirzotamab-ADC-Tb1-15 linker
 [1]
 ADC Info 
Mirzotamab-ADC-Tb1-16
Mirzotamab-ADC-Tb1-16 payload
Undisclosed
Mirzotamab-ADC-Tb1-16 linker
 [1]
 ADC Info 
Mirzotamab-ADC-Tb1-17
Mirzotamab-ADC-Tb1-17 payload
Undisclosed
Mirzotamab-ADC-Tb1-17 linker
 [1]
 ADC Info 
Mirzotamab-ADC-Tb1-18
Mirzotamab-ADC-Tb1-18 payload
Undisclosed
Mirzotamab-ADC-Tb1-18 linker
 [1]
 ADC Info 
Mirzotamab-ADC-Tb1-19
Mirzotamab-ADC-Tb1-19 payload
Undisclosed
Mirzotamab-ADC-Tb1-19 linker
 [1]
 ADC Info 
Mirzotamab-ADC-Tb1-2
Mirzotamab-ADC-Tb1-2 payload
Undisclosed
Mirzotamab-ADC-Tb1-2 linker
 [1]
 ADC Info 
Mirzotamab-ADC-Tb1-20
Mirzotamab-ADC-Tb1-20 payload
Undisclosed
Mirzotamab-ADC-Tb1-20 linker
 [1]
 ADC Info 
Mirzotamab-ADC-Tb1-21
Mirzotamab-ADC-Tb1-21 payload
Undisclosed
Mirzotamab-ADC-Tb1-21 linker
 [1]
 ADC Info 
Mirzotamab-ADC-Tb1-22
Mirzotamab-ADC-Tb1-22 payload
Undisclosed
Mirzotamab-ADC-Tb1-22 linker
 [1]
 ADC Info 
Mirzotamab-ADC-Tb1-23
Mirzotamab-ADC-Tb1-23 payload
Undisclosed
Mirzotamab-ADC-Tb1-23 linker
 [1]
 ADC Info 
Mirzotamab-ADC-Tb1-24
Mirzotamab-ADC-Tb1-24 payload
Undisclosed
Mirzotamab-ADC-Tb1-24 linker
 [1]
 ADC Info 
Mirzotamab-ADC-Tb1-25
Mirzotamab-ADC-Tb1-25 payload
Undisclosed
Mirzotamab-ADC-Tb1-25 linker
 [1]
 ADC Info 
Mirzotamab-ADC-Tb1-26
Mirzotamab-ADC-Tb1-26 payload
Undisclosed
Mirzotamab-ADC-Tb1-26 linker
 [1]
 ADC Info 
Mirzotamab-ADC-Tb1-3
Mirzotamab-ADC-Tb1-3 payload
Undisclosed
Mirzotamab-ADC-Tb1-3 linker
 [1]
 ADC Info 
Mirzotamab-ADC-Tb1-4
Mirzotamab-ADC-Tb1-4 payload
Undisclosed
Mirzotamab-ADC-Tb1-4 linker
 [1]
 ADC Info 
Mirzotamab-ADC-Tb1-5
Mirzotamab-ADC-Tb1-5 payload
Undisclosed
Mirzotamab-ADC-Tb1-5 linker
 [1]
 ADC Info 
Mirzotamab-ADC-Tb1-6
Mirzotamab-ADC-Tb1-6 payload
Undisclosed
Mirzotamab-ADC-Tb1-6 linker
 [1]
 ADC Info 
Mirzotamab-ADC-Tb1-7
Mirzotamab-ADC-Tb1-7 payload
Undisclosed
Mirzotamab-ADC-Tb1-7 linker
 [1]
 ADC Info 
Mirzotamab-ADC-Tb1-8
Mirzotamab-ADC-Tb1-8 payload
Undisclosed
Mirzotamab-ADC-Tb1-8 linker
 [1]
 ADC Info 
Mirzotamab-ADC-Tb1-9
Mirzotamab-ADC-Tb1-9 payload
Undisclosed
Mirzotamab-ADC-Tb1-9 linker
 [1]
Omburtamab
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
Omburtamab-ADC-Tb1-1
Omburtamab-ADC-Tb1-1 payload
Undisclosed
Omburtamab-ADC-Tb1-1 linker
 [1]
 ADC Info 
Omburtamab-ADC-Tb1-10
Omburtamab-ADC-Tb1-10 payload
Undisclosed
Omburtamab-ADC-Tb1-10 linker
 [1]
 ADC Info 
Omburtamab-ADC-Tb1-11
Omburtamab-ADC-Tb1-11 payload
Undisclosed
Omburtamab-ADC-Tb1-11 linker
 [1]
 ADC Info 
Omburtamab-ADC-Tb1-12
Omburtamab-ADC-Tb1-12 payload
Undisclosed
Omburtamab-ADC-Tb1-12 linker
 [1]
 ADC Info 
Omburtamab-ADC-Tb1-13
Omburtamab-ADC-Tb1-13 payload
Undisclosed
Omburtamab-ADC-Tb1-13 linker
 [1]
 ADC Info 
Omburtamab-ADC-Tb1-14
Omburtamab-ADC-Tb1-14 payload
Undisclosed
Omburtamab-ADC-Tb1-14 linker
 [1]
 ADC Info 
Omburtamab-ADC-Tb1-15
Omburtamab-ADC-Tb1-15 payload
Undisclosed
Omburtamab-ADC-Tb1-15 linker
 [1]
 ADC Info 
Omburtamab-ADC-Tb1-16
Omburtamab-ADC-Tb1-16 payload
Undisclosed
Omburtamab-ADC-Tb1-16 linker
 [1]
 ADC Info 
Omburtamab-ADC-Tb1-17
Omburtamab-ADC-Tb1-17 payload
Undisclosed
Omburtamab-ADC-Tb1-17 linker
 [1]
 ADC Info 
Omburtamab-ADC-Tb1-18
Omburtamab-ADC-Tb1-18 payload
Undisclosed
Omburtamab-ADC-Tb1-18 linker
 [1]
 ADC Info 
Omburtamab-ADC-Tb1-19
Omburtamab-ADC-Tb1-19 payload
Undisclosed
Omburtamab-ADC-Tb1-19 linker
 [1]
 ADC Info 
Omburtamab-ADC-Tb1-2
Omburtamab-ADC-Tb1-2 payload
Undisclosed
Omburtamab-ADC-Tb1-2 linker
 [1]
 ADC Info 
Omburtamab-ADC-Tb1-20
Omburtamab-ADC-Tb1-20 payload
Undisclosed
Omburtamab-ADC-Tb1-20 linker
 [1]
 ADC Info 
Omburtamab-ADC-Tb1-21
Omburtamab-ADC-Tb1-21 payload
Undisclosed
Omburtamab-ADC-Tb1-21 linker
 [1]
 ADC Info 
Omburtamab-ADC-Tb1-22
Omburtamab-ADC-Tb1-22 payload
Undisclosed
Omburtamab-ADC-Tb1-22 linker
 [1]
 ADC Info 
Omburtamab-ADC-Tb1-23
Omburtamab-ADC-Tb1-23 payload
Undisclosed
Omburtamab-ADC-Tb1-23 linker
 [1]
 ADC Info 
Omburtamab-ADC-Tb1-24
Omburtamab-ADC-Tb1-24 payload
Undisclosed
Omburtamab-ADC-Tb1-24 linker
 [1]
 ADC Info 
Omburtamab-ADC-Tb1-25
Omburtamab-ADC-Tb1-25 payload
Undisclosed
Omburtamab-ADC-Tb1-25 linker
 [1]
 ADC Info 
Omburtamab-ADC-Tb1-26
Omburtamab-ADC-Tb1-26 payload
Undisclosed
Omburtamab-ADC-Tb1-26 linker
 [1]
 ADC Info 
Omburtamab-ADC-Tb1-3
Omburtamab-ADC-Tb1-3 payload
Undisclosed
Omburtamab-ADC-Tb1-3 linker
 [1]
 ADC Info 
Omburtamab-ADC-Tb1-4
Omburtamab-ADC-Tb1-4 payload
Undisclosed
Omburtamab-ADC-Tb1-4 linker
 [1]
 ADC Info 
Omburtamab-ADC-Tb1-5
Omburtamab-ADC-Tb1-5 payload
Undisclosed
Omburtamab-ADC-Tb1-5 linker
 [1]
 ADC Info 
Omburtamab-ADC-Tb1-6
Omburtamab-ADC-Tb1-6 payload
Undisclosed
Omburtamab-ADC-Tb1-6 linker
 [1]
 ADC Info 
Omburtamab-ADC-Tb1-7
Omburtamab-ADC-Tb1-7 payload
Undisclosed
Omburtamab-ADC-Tb1-7 linker
 [1]
 ADC Info 
Omburtamab-ADC-Tb1-8
Omburtamab-ADC-Tb1-8 payload
Undisclosed
Omburtamab-ADC-Tb1-8 linker
 [1]
 ADC Info 
Omburtamab-ADC-Tb1-9
Omburtamab-ADC-Tb1-9 payload
Undisclosed
Omburtamab-ADC-Tb1-9 linker
 [1]
Risvutatug
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
HS-20093
Exatecan derivative (HS-9265)
DNA topoisomerase 1 (TOP1)
Maleimide tetrapeptide linker
 [11]
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
Anti-B7H3 APDC 3f
Kinesin spindle protein (KSP) inhibitor 3f
Kinesin-like protein KIF11 (KIF11)
Open-chain glycine maleimide
 [12]
 ADC Info 
Anti-B7H3 APDC 3g
Kinesin spindle protein (KSP) inhibitor 3g
Kinesin-like protein KIF11 (KIF11)
Open-chain glycine maleimide
 [12]
Vobramitamab
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
Vobramitamab duocarmazine
seco-DUBA
Human Deoxyribonucleic acid (hDNA)
Mal-PEG2-Val-Cit-PABA-Cyclization Spacer
 [13]
Undisclosed
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
YL-201
YL0010014
DNA topoisomerase 1 (TOP1)
Tumor microenviroment activable tripeptide linker
 [14]
 ADC Info 
DB-1311
P1021
DNA topoisomerase 1 (TOP1)
Maleimide tetrapeptide-based cleavable linker
 [15]
 ADC Info 
IBI-129
Undisclosed
DNA topoisomerase 1 (TOP1)
Undisclosed
 [16]
 ADC Info 
ILB-3101
Eribulin
Microtubule (MT)
Undisclosed
 [17]
 ADC Info 
MHB-088C
DNA topoisomerase I inhibitor
DNA topoisomerase 1 (TOP1)
Protease- hydrolyzable linker
 [18]
 ADC Info 
BAT8009
Exatecan
DNA topoisomerase 1 (TOP1)
Cleavable linker
 [19]
 ADC Info 
64Cu-DOTAGA-alphaCD276 mAb
Undisclosed
Undisclosed
Undisclosed
 [20]
 ADC Info 
7MW-3711
Topoisomerase I inhibitor
DNA topoisomerase 1 (TOP1)
Undisclosed
 [21]
 ADC Info 
B7-H3 ADC (Jiangsu hengrui)
Undisclosed
Undisclosed
Undisclosed
 [22]
 ADC Info 
B7H3-MMAE
Monomethyl auristatin E
Microtubule (MT)
Undisclosed
 [23]
 ADC Info 
BVD-CD276
Undisclosed
Undisclosed
Undisclosed
 [24]
 ADC Info 
NV104
Irinotecan
DNA topoisomerase 1 (TOP1)
Undisclosed
 [25]
 ADC Info 
NV105
Temozolomide
Human Deoxyribonucleic acid (hDNA)
Undisclosed
 [25]
 ADC Info 
NV106
Panobinostat
Histone deacetylase 1 (HDAC1)
Undisclosed
 [25]
 ADC Info 
YBL-015
Undisclosed
Undisclosed
Undisclosed
 [26]
References
Ref 1 Bioactive substance conjugate, preparation method therefor and use thereof; 2022-08-18.
Ref 2 Ligand-drug conjugate of exatecan analogue, preparation method therefor and application thereof; 2020-04-02.
Ref 3 Anti-b7h3 antibody-exatecan analog conjugate and medicinal use thereof; 2020-04-02.
Ref 4 The B7-H3-Targeting Antibody-Drug Conjugate m276-SL-PBD Is Potently Effective Against Pediatric Cancer Preclinical Solid Tumor Models. Clin Cancer Res. 2021 May 15;27(10):2938-2946. doi: 10.1158/1078-0432.CCR-20-4221. Epub 2021 Feb 22.
Ref 5 A Novel NAMPT Inhibitor-Based Antibody-Drug Conjugate Payload Class for Cancer Therapy. Bioconjug Chem. 2022 Jun 15;33(6):1210-1221.
Ref 6 Novel B7-H3- binding molecule, its antibody drug conjugate and its application method.
Ref 7 Anti-b7-h3 antibodies and antibody drug conjugates; 2018-03-08.
Ref 8 Novel b7-h3 binding molecules, antibody drug conjugates thereof and methods of use thereof; 2017-10-19.
Ref 9 Ifinatamab deruxtecan (I-DXd), a novel B7-H3-targeting antibody-drug conjugate, demonstrates efficient payload delivery into tumor through target-dependent internalization. Cancer Res (2023) 83 (7_Supplement): 4891.
Ref 10 A first-in-human study of mirzotamab clezutoclax as monotherapy and in combination with taxane therapy in relapsed/refractory solid tumors: Dose escalation results. Journal of Clinical Oncology 2021 39:15_suppl, 3015-3015.
Ref 11 ARTEMIS-002: HS-20093 in Patients With Relapsed or Refractory Osteosarcoma and Other Sarcomas
Ref 12 Antibody-Prodrug Conjugates with KSP Inhibitors and Legumain-Mediated Metabolite Formation. Chemistry. 2019 Jun 21;25(35):8208-8213. doi: 10.1002/chem.201900441. Epub 2019 Apr 15.
Ref 13 Anti-tumor activity of vobramitamab duocarmazine (MGC018), an investigational duocarmycin-based anti-B7-H3 antibody-drug conjugate (ADC), in preclinical neuroblastoma models. Cancer Res (2023) 83 (7_Supplement): 2981.
Ref 14 A Study of YL201 in Patients With Advanced Solid Tumors; NCT05434234.
Ref 15 Preclinical development of a B7-H3-targeting ADC with a novel DNA topoisomerase I inhibitor for solid tumors. Cancer Res (2023) 83 (7_Supplement): 2967.
Ref 16 Innoventbio 2022 Annual Performance Report.
Ref 17 Innolake biopharm biotechnology company product pipeline
Ref 18 Study of MHB088C in Participants With Advanced or Metastatic Solid Tumors; NCT05652855.
Ref 19 Assess Safety, Tolerability, Pharmacokinetics, and Preliminary Efficacy of BAT8009; NCT05405621.
Ref 20 Introduction to basic information on ADC drug 64Cu-DOTAGA-alphaCD276 mAb (Provenance).
Ref 21 Clinical Trial Application for 7MW3711 - an Innovative Drug Developed by Mabwell's ADC Platform, Accepted by NMPA.
Ref 22 Introduction to basic information on ADC drug B7-H3 ADC (Jiangsu hengrui).
Ref 23 Anwita biosciences product pipeline
Ref 24 Biomed valley discoveries product pipeline
Ref 25 Nanovalent pharmaceuticals product pipeline
Ref 26 Y-Biologics biotechnology company product pipeline