General Information of This Antigen
Antigen ID
TAR0GLSWQ
Antigen Name
CD276 antigen (CD276)
Gene Name
CD276
Gene ID
80381
Synonym
B7H3; PSEC0249; UNQ309; PRO352; 4Ig-B7-H3;B7 homolog 3;Costimulatory molecule;CD_antigen=CD276
Sequence
MLRRRGSPGMGVHVGAALGALWFCLTGALEVQVPEDPVVALVGTDATLCCSFSPEPGFSL
AQLNLIWQLTDTKQLVHSFAEGQDQGSAYANRTALFPDLLAQGNASLRLQRVRVADEGSF
TCFVSIRDFGSAAVSLQVAAPYSKPSMTLEPNKDLRPGDTVTITCSSYQGYPEAEVFWQD
GQGVPLTGNVTTSQMANEQGLFDVHSILRVVLGANGTYSCLVRNPVLQQDAHSSVTITPQ
RSPTGAVEVQVPEDPVVALVGTDATLRCSFSPEPGFSLAQLNLIWQLTDTKQLVHSFTEG
RDQGSAYANRTALFPDLLAQGNASLRLQRVRVADEGSFTCFVSIRDFGSAAVSLQVAAPY
SKPSMTLEPNKDLRPGDTVTITCSSYRGYPEAEVFWQDGQGVPLTGNVTTSQMANEQGLF
DVHSVLRVVLGANGTYSCLVRNPVLQQDAHGSVTITGQPMTFPPEALWVTVGLSVCLIAL
LVALAFVCWRKIKQSCEEENAGAEDQDGEGEGSKTALQPLKHSDSKEDDGQEIA

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Family
HIV-1 env protein family
Function
May participate in the regulation of T-cell-mediated immune response. May play a protective role in tumor cells by inhibiting natural-killer mediated cell lysis as well as a role of marker for detection of neuroblastoma cells. May be involved in the development of acute and chronic transplant rejection and in the regulation of lymphocytic activity at mucosal surfaces. Could also play a key role in providing the placenta and fetus with a suitable immunological environment throughout pregnancy. Both isoform 1 and isoform 2 appear to be redundant in their ability to modulate CD4 T-cell responses. Isoform 2 is shown to enhance the induction of cytotoxic T-cells and selectively stimulates interferon gamma production in the presence of T-cell receptor signaling.

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Uniprot Entry
CD276_HUMAN
HGNC ID
HGNC:19137
KEGG ID
hsa:80381
Each Antibody-drug Conjuate AND It's Component Related to This Antigen
Full List of The ADC Related to This Antigen
ADC Info ADC Name Payload Target Linker Ref
1D1-01-ADC-Tb1-1
1D1-01-ADC-Tb1-1 payload
Undisclosed
1D1-01-ADC-Tb1-1 linker
[1]
1D1-01-ADC-Tb1-2
1D1-01-ADC-Tb1-2 payload
Undisclosed
1D1-01-ADC-Tb1-2 linker
[1]
1D1-01-ADC-Tb1-3
1D1-01-ADC-Tb1-3 payload
Undisclosed
1D1-01-ADC-Tb1-3 linker
[1]
1D1-01-ADC-Tb1-4
1D1-01-ADC-Tb1-4 payload
Undisclosed
1D1-01-ADC-Tb1-4 linker
[1]
1D1-01-ADC-Tb1-5
1D1-01-ADC-Tb1-5 payload
Undisclosed
1D1-01-ADC-Tb1-5 linker
[1]
1D1-01-ADC-Tb1-6
1D1-01-ADC-Tb1-6 payload
Undisclosed
1D1-01-ADC-Tb1-6 linker
[1]
1D1-01-ADC-Tb1-7
1D1-01-ADC-Tb1-7 payload
Undisclosed
1D1-01-ADC-Tb1-7 linker
[1]
1D1-01-ADC-Tb1-8
1D1-01-ADC-Tb1-8 payload
Undisclosed
1D1-01-ADC-Tb1-8 linker
[1]
1D1-01-ADC-Tb1-9
1D1-01-ADC-Tb1-9 payload
Undisclosed
1D1-01-ADC-Tb1-9 linker
[1]
1D1-01-ADC-Tb1-10
1D1-01-ADC-Tb1-10 payload
Undisclosed
1D1-01-ADC-Tb1-10 linker
[1]
1D1-01-ADC-Tb1-11
1D1-01-ADC-Tb1-11 payload
Undisclosed
1D1-01-ADC-Tb1-11 linker
[1]
1D1-01-ADC-Tb1-12
1D1-01-ADC-Tb1-12 payload
Undisclosed
1D1-01-ADC-Tb1-12 linker
[1]
1D1-01-ADC-Tb1-13
1D1-01-ADC-Tb1-13 payload
Undisclosed
1D1-01-ADC-Tb1-13 linker
[1]
1D1-01-ADC-Tb1-14
1D1-01-ADC-Tb1-14 payload
Undisclosed
1D1-01-ADC-Tb1-14 linker
[1]
1D1-01-ADC-Tb1-15
1D1-01-ADC-Tb1-15 payload
Undisclosed
1D1-01-ADC-Tb1-15 linker
[1]
1D1-01-ADC-Tb1-16
1D1-01-ADC-Tb1-16 payload
Undisclosed
1D1-01-ADC-Tb1-16 linker
[1]
1D1-01-ADC-Tb1-17
1D1-01-ADC-Tb1-17 payload
Undisclosed
1D1-01-ADC-Tb1-17 linker
[1]
1D1-01-ADC-Tb1-18
1D1-01-ADC-Tb1-18 payload
Undisclosed
1D1-01-ADC-Tb1-18 linker
[1]
1D1-01-ADC-Tb1-19
1D1-01-ADC-Tb1-19 payload
Undisclosed
1D1-01-ADC-Tb1-19 linker
[1]
1D1-01-ADC-Tb1-20
1D1-01-ADC-Tb1-20 payload
Undisclosed
1D1-01-ADC-Tb1-20 linker
[1]
1D1-01-ADC-Tb1-21
1D1-01-ADC-Tb1-21 payload
Undisclosed
1D1-01-ADC-Tb1-21 linker
[1]
1D1-01-ADC-Tb1-22
1D1-01-ADC-Tb1-22 payload
Undisclosed
1D1-01-ADC-Tb1-22 linker
[1]
1D1-01-ADC-Tb1-23
1D1-01-ADC-Tb1-23 payload
Undisclosed
1D1-01-ADC-Tb1-23 linker
[1]
1D1-01-ADC-Tb1-24
1D1-01-ADC-Tb1-24 payload
Undisclosed
1D1-01-ADC-Tb1-24 linker
[1]
1D1-01-ADC-Tb1-25
1D1-01-ADC-Tb1-25 payload
Undisclosed
1D1-01-ADC-Tb1-25 linker
[1]
1D1-01-ADC-Tb1-26
1D1-01-ADC-Tb1-26 payload
Undisclosed
1D1-01-ADC-Tb1-26 linker
[1]
ADC Info ADC Name Payload Target Linker Ref
WO2020063676A1 ADC-25
WO2020063676A1_ADC-25 payload
Undisclosed
WO2020063676A1_ADC-25 linker
[2]
WO2020063676A1 ADC-26
WO2020063676A1_ADC-26 payload
Undisclosed
WO2020063676A1_ADC-26 linker
[2]
WO2020063676A1 ADC-27
WO2020063676A1_ADC-27 payload
Undisclosed
WO2020063676A1_ADC-27 linker
[2]
WO2020063676A1 ADC-28
WO2020063676A1_ADC-28 payload
Undisclosed
WO2020063676A1_ADC-28 linker
[2]
WO2020063676A1 ADC-29
WO2020063676A1_ADC-29 payload
Undisclosed
WO2020063676A1_ADC-29 linker
[2]
WO2020063676A1 ADC-30
WO2020063676A1_ADC-30 payload
Undisclosed
WO2020063676A1_ADC-30 linker
[2]
WO2020063676A1 ADC-31
WO2020063676A1_ADC-31 payload
Undisclosed
WO2020063676A1_ADC-31 linker
[2]
ADC Info ADC Name Payload Target Linker Ref
40285886 7300-LP1003
Camptothecin derivative 095
Undisclosed
a polyethylene glycol-modified straight-link agent
[3]
40285886 7300-LP2004
Camptothecin derivative 095
Undisclosed
a polyethylene glycol-modified branched-link agent
[3]
40285886 7300-LP3004
Camptothecin derivative 095
Undisclosed
a PSar-modified branched-link agent
[3]
40285886 7300-Deruxtecan
DX-8951 derivative (DXd)
DNA topoisomerase 1 (TOP1)
Mc-Gly-Gly-Phe-Gly
[3]
Anti-b7h3
ADC Info ADC Name Payload Target Linker Ref
WBP301088-X2
Topo1 inhibitor F
DNA topoisomerase I (TOP1)
Mc-Gly-Gly-Phe-Gly
[4]
Anti-B7H3 mAb 2E3-02
ADC Info ADC Name Payload Target Linker Ref
B7H3-ADC-01
B7H3-ADC-01 payload
Undisclosed
B7H3-ADC-01 linker
[1]
B7H3-ADC-02
B7H3-ADC-02 payload
Undisclosed
B7H3-ADC-02 linker
[1]
B7H3-ADC-03
B7H3-ADC-03 payload
Undisclosed
B7H3-ADC-03 linker
[1]
B7H3-ADC-04 (DAR8)
B7H3-ADC-04 payload
Undisclosed
B7H3-ADC-04 linker
[1]
B7H3-ADC-05 (DAR8)
B7H3-ADC-05(DAR8) payload
Undisclosed
B7H3-ADC-05(DAR8) linker
[1]
B7H3-ADC-05 (DAR4)
B7H3-ADC-05(DAR8) payload
Undisclosed
B7H3-ADC-05(DAR4) linker
[1]
B7H3-ADC-06 (DAR8)
B7H3-ADC-06 payload
Undisclosed
B7H3-ADC-06 linker
[1]
B7H3-ADC-07 (DAR8)
B7H3-ADC-07(DAR8) payload
Undisclosed
B7H3-ADC-07(DAR8) linker
[1]
B7H3-ADC-07 (DAR2)
B7H3-ADC-07(DAR2) payload
Undisclosed
B7H3-ADC-07(DAR2) linker
[1]
B7H3-ADC-07 (DAR4)
B7H3-ADC-07(DAR4) payload
Undisclosed
B7H3-ADC-07(DAR4) linker
[1]
B7H3-ADC-07 (DAR6)
B7H3-ADC-07(DAR6) payload
Undisclosed
B7H3-ADC-07(DAR6) linker
[1]
B7H3-ADC-08 (DAR8)
B7H3-ADC-08(DAR8) payload
Undisclosed
B7H3-ADC-08(DAR8) linker
[1]
B7H3-ADC-08 (DAR4)
B7H3-ADC-08(DAR4) payload
Undisclosed
B7H3-ADC-08(DAR4) linker
[1]
B7H3-ADC-09 (DAR8)
B7H3-ADC-09 payload
Undisclosed
B7H3-ADC-09 linker
[1]
B7H3-ADC-10 (DAR8)
B7H3-ADC-10 payload
Undisclosed
B7H3-ADC-10 linker
[1]
B7H3-ADC-11 (DAR8)
B7H3-ADC-11 payload
Undisclosed
B7H3-ADC-11 linker
[1]
B7H3-ADC-12 (DAR8)
B7H3-ADC-12 payload
Undisclosed
B7H3-ADC-12 linker
[1]
B7H3-ADC-13 (DAR8)
B7H3-ADC-13 payload
Undisclosed
B7H3-ADC-13 linker
[1]
B7H3-ADC-14 (DAR8)
B7H3-ADC-14 payload
Undisclosed
B7H3-ADC-14 linker
[1]
B7H3-ADC-15 (DAR8)
B7H3-ADC-15(DAR8) payload
Undisclosed
B7H3-ADC-15(DAR8) linker
[1]
B7H3-ADC-15 (DAR4)
B7H3-ADC-15(DAR4) payload
Undisclosed
B7H3-ADC-15(DAR4) linker
[1]
B7H3-ADC-16 (DAR8)
B7H3-ADC-16 payload
Undisclosed
B7H3-ADC-16 linker
[1]
B7H3-ADC-17
B7H3-ADC-17 payload
Undisclosed
B7H3-ADC-17 linker
[1]
B7H3-ADC-18 (DAR8)
B7H3-ADC-18 payload
Undisclosed
B7H3-ADC-18 linker
[1]
B7H3-ADC-19 (DAR8)
B7H3-ADC-19 payload
Undisclosed
B7H3-ADC-19 linker
[1]
B7H3-ADC-20 (DAR8)
B7H3-ADC-20 payload
Undisclosed
B7H3-ADC-20 linker
[1]
B7H3-ADC-22 (DAR8)
B7H3-ADC-22 payload
Undisclosed
B7H3-ADC-22 linker
[1]
B7H3-ADC-23 (DAR8)
B7H3-ADC-23 payload
Undisclosed
B7H3-ADC-23 linker
[1]
B7H3-ADC-24 (DAR8)
B7H3-ADC-24 payload
Undisclosed
B7H3-ADC-24 linker
[1]
B7H3-ADC-25 (DAR8)
B7H3-ADC-25 payload
Undisclosed
B7H3-ADC-25 linker
[1]
B7H3-ADC-27 (DAR8)
B7H3-ADC-27 payload
Undisclosed
B7H3-ADC-27 linker
[1]
B7H3-ADC-28 (DAR8)
B7H3-ADC-28 payload
Undisclosed
B7H3-ADC-28 linker
[1]
B7H3-ADC-32 (DAR8)
B7H3-ADC-32 payload
Undisclosed
B7H3-ADC-32 linker
[1]
B7H3-ADC-33 (DAR8)
B7H3-ADC-33(DAR8) payload
Undisclosed
B7H3-ADC-33(DAR8) linker
[1]
B7H3-ADC-33 (DAR4)
B7H3-ADC-33(DAR4) payload
Undisclosed
B7H3-ADC-33(DAR4) linker
[1]
B7H3-ADC-001
DL014-payload; DL003-payload
Undisclosed
DL014-Linker; DL003-Linker
[5]
B7H3-ADC-002
DL014-payload; DL003-payload
Undisclosed
DL014-Linker; DL003-Linker
[5]
B7H3-ADC-003
DL014-payload; DL003-payload
Undisclosed
DL014-Linker; DL003-Linker
[5]
Anti-CD276 mAb
ADC Info ADC Name Payload Target Linker Ref
Anti-CD276 mAb-MMAF
Monomethyl auristatin F
Microtubule (MT)
Undisclosed
[6]
Anti-CD276 mAb h1702DS
ADC Info ADC Name Payload Target Linker Ref
WO2020063673A1 ADC-1
WO2020063673A1_ADC-1 payload
Undisclosed
WO2020063673A1_ADC-1 linker
[7]
WO2020063673A1 ADC-2
WO2020063673A1_ADC-2 payload
Undisclosed
WO2020063673A1_ADC-2 linker
[7]
WO2020063673A1 ADC-3
WO2020063673A1_ADC-3 payload
Undisclosed
WO2020063673A1_ADC-3 linker
[7]
WO2020063673A1 ADC-4
WO2020063673A1_ADC-4 payload
Undisclosed
WO2020063673A1_ADC-4 linker
[7]
WO2020063673A1 ADC-5
WO2020063673A1_ADC-5 payload
Undisclosed
WO2020063673A1_ADC-5 linker
[7]
WO2020063673A1 ADC-6
WO2020063673A1_ADC-6 payload
Undisclosed
WO2020063673A1_ADC-6 linker
[7]
WO2020063673A1 ADC-7
WO2020063673A1_ADC-7 payload
Undisclosed
WO2020063673A1_ADC-7 linker
[7]
WO2020063673A1 ADC-8
WO2020063673A1_ADC-8 payload
Undisclosed
WO2020063673A1_ADC-8 linker
[7]
Anti-CD276 mAb m276-SL
ADC Info ADC Name Payload Target Linker Ref
M276-SL-PBD
PBD dimer
Human Deoxyribonucleic acid (hDNA)
Mc-Val-Ala
[8]
Anti-human CD276 mAb
ADC Info ADC Name Payload Target Linker Ref
B7H3-EC3 DAR4.1
NAMPT inhibitor 4
Nicotinamide phosphoribosyltransferase (NAMPT)
Mc-Val-Ala
[9]
B7H3-EC3 DAR7.8
NAMPT inhibitor 4
Nicotinamide phosphoribosyltransferase (NAMPT)
Mc-Val-Ala
[9]
B7H3-EC5
NAMPT inhibitor 6
Nicotinamide phosphoribosyltransferase (NAMPT)
Open-chain glycine maleimide-PEG
[9]
B7H3-EC4
NAMPT inhibitor 5
Nicotinamide phosphoribosyltransferase (NAMPT)
Open-chain glycine maleimide
[9]
B7H3-EC2
NAMPT inhibitor 6
Nicotinamide phosphoribosyltransferase (NAMPT)
Maleimido-caproyl
[9]
B7H3-EC1
NAMPT inhibitor 4
Nicotinamide phosphoribosyltransferase (NAMPT)
Maleimido-caproyl
[9]
CN109069633A ADC-1
CN109069633A ADC-1 payload
Undisclosed
CN109069633A ADC-1 linker
[10]
CN109069633A ADC-2
CN109069633A ADC-2 payload
Undisclosed
CN109069633A ADC-2 linker
[10]
CN109069633A ADC-3
CN109069633A ADC-3 payload
Undisclosed
CN109069633A ADC-3 linker
[10]
Antibody V3
ADC Info ADC Name Payload Target Linker Ref
CN115969996A ADC1
Exatecan
DNA topoisomerase 1 (TOP1)
CB07 linker
[11]
CN115969996A ADC2
DX-8951 derivative (DXd)
DNA topoisomerase 1 (TOP1)
Mc-Gly-Gly-Phe-Gly
[11]
CN115969996A ADC3
Exatecan
DNA topoisomerase 1 (TOP1)
CB07 linker
[11]
B7-H3 mAb 401
ADC Info ADC Name Payload Target Linker Ref
37235999 ADC 401-4
Monomethyl auristatin E
Microtubule (MT)
Fmoc-Val-Cit-PAB-PNP
[12]
B7-H3-ABBV-155
ADC Info ADC Name Payload Target Linker Ref
B7-H3-ABBV-155-L101-D101
Compound D101
Undisclosed
L101 linker
[13]
B7-H3-ABBV-155-L102-D101
Compound D101
Undisclosed
L102 linker
[13]
B7-H3-ABBV-155-L103-D101
Compound D101
Undisclosed
L103 linker
[13]
B7-H3-ABBV-155-L101-D102
Compound D102
Undisclosed
L101 linker
[13]
B7-H3-ABBV-155-L101-D103
Compound D103
Undisclosed
L101 linker
[13]
B7-H3-ABBV-155-L101-D104
Compound D104
Undisclosed
L101 linker
[13]
B7-H3-ABBV-155-L102-D102
Compound D102
Undisclosed
L102 linker
[13]
B7-H3-ABBV-155-L102-D103
Compound D103
Undisclosed
L102 linker
[13]
B7-H3-ABBV-155-L102-D104
Compound D104
Undisclosed
L102 linker
[13]
B7-H3-DS-5573a
ADC Info ADC Name Payload Target Linker Ref
B7-H3-DS-5573a-L101-D101
Compound D101
Undisclosed
L101 linker
[13]
B7-H3-DS-5573a-L102-D101
Compound D101
Undisclosed
L102 linker
[13]
B7-H3-DS-5573a-L103-D101
Compound D101
Undisclosed
L103 linker
[13]
B7-H3-DS-5573a-L101-D102
Compound D102
Undisclosed
L101 linker
[13]
B7-H3-DS-5573a-L101-D103
Compound D103
Undisclosed
L101 linker
[13]
B7-H3-DS-5573a-L101-D104
Compound D104
Undisclosed
L101 linker
[13]
B7-H3-DS-5573a-L102-D102
Compound D102
Undisclosed
L102 linker
[13]
B7-H3-DS-5573a-L102-D103
Compound D103
Undisclosed
L102 linker
[13]
B7-H3-DS-5573a-L102-D104
Compound D104
Undisclosed
L102 linker
[13]
B7H3 antibody
ADC Info ADC Name Payload Target Linker Ref
CN115429893A ADC15
Undisclosed
Undisclosed
Undisclosed
[14]
B7H3 Y107 A121C
ADC Info ADC Name Payload Target Linker Ref
CN118414170A T-2-AB
T-2
Undisclosed
T-2 linker
[15]
CN118414170A T-3-AB
T-3
Undisclosed
T-3 linker
[15]
CN118414170A T-4-AB
T-4
Undisclosed
T-4 linker
[15]
CN118414170A T-5-AB
T-3
Undisclosed
T-5 linker
[15]
CN118414170A T-6-AB
T-6
Undisclosed
T-6 linker
[15]
CN118414170A T-8-AB
T-8
Undisclosed
T-8 linker
[15]
CN118414170A T-9-AB
T-9
Undisclosed
T-9 linker
[15]
CN118414170A T-10-AB
T-10
Undisclosed
T-5 linker
[15]
CN118414170A T-11-AB
T-11
Undisclosed
T-5 linker
[15]
CN118414170A T-12-AB
T-12
Undisclosed
T-5 linker
[15]
CN118414170A T-13-AB
T-13
Undisclosed
T-5 linker
[15]
CN118414170A T-14-AB
T-14
Undisclosed
T-14 linker
[15]
CN118414170A T-15-AB
T-15
Undisclosed
T-4 linker
[15]
CN118414170A T-102-AB
T-102
Undisclosed
T-102 linker
[15]
CN118414170A T-103-AB
T-103
Undisclosed
T-102 linker
[15]
CN118414170A T-104-AB
T-104
Undisclosed
T-102 linker
[15]
CN118414170A T-110-AB
T-110
Undisclosed
T-102 linker
[15]
CN118414170A T-111-AB
T-111
Undisclosed
T-102 linker
[15]
CN118414170A T-112-AB
T-112
Undisclosed
T-102 linker
[15]
CN118414170A T-113-AB
T-113
Undisclosed
T-102 linker
[15]
CN118414170A T-115-AB
T-115
Undisclosed
T-102 linker
[15]
CN118414170A T-116-AB
T-116
Undisclosed
T-102 linker
[15]
CN118414170A T-117-AB
T-116
Undisclosed
T-117 linker
[15]
CN118414170A T-118-AB
T-118
Undisclosed
T-102 linker
[15]
CN118414170A T-119-AB
T-119
Undisclosed
T-102 linker
[15]
CN118414170A T-120-AB
T-120
Undisclosed
T-102 linker
[15]
CN118414170A T-121-AB
T-121
Undisclosed
T-102 linker
[15]
CN118414170A T-122-AB
T-122
Undisclosed
T-102 linker
[15]
CN118414170A T-123-AB
T-123
Undisclosed
T-102 linker
[15]
CN118414170A T-124-AB
T-122
Undisclosed
T-124 linker
[15]
CN118414170A T-125-AB
T-123
Undisclosed
T-125 linker
[15]
CN118414170A T-127-AB
T-122
Undisclosed
Undisclosed
[15]
CN118414170A T-129-AB
T-129
Undisclosed
Undisclosed
[15]
CN118414170A T-132-AB
T-132
Undisclosed
T-132 linker
[15]
CN118414170A T-133-AB
T-133
Undisclosed
T-132 linker
[15]
CN118414170A T-134-AB
T-134
Undisclosed
T-132 linker
[15]
CN118414170A T-135-AB
T-135
Undisclosed
T-132 linker
[15]
ADC Info ADC Name Payload Target Linker Ref
B7H3-C1-ADC-05 (DAR4)
B7H3-C1-ADC-05(DAR4) payload
Undisclosed
B7H3-C1-ADC-05(DAR4) linker
[1]
B7H3-C1-ADC-07 (DAR4)
B7H3-C1-ADC-07(DAR4) payload
Undisclosed
B7H3-C1-ADC-07(DAR4) linker
[1]
B7H3-C1-ADC-08 (DAR4)
B7H3-C1-ADC-08(DAR4) payload
Undisclosed
B7H3-C1-ADC-08(DAR4) linker
[1]
B7H3-ADC-21 (DAR8)
B7H3-ADC-21(DAR8) payload
Undisclosed
B7H3-ADC-21(DAR8) linker
[1]
B7H3-ADC-21 (DAR2)
B7H3-ADC-21(DAR2) payload
Undisclosed
B7H3-ADC-21(DAR2) linker
[1]
B7H3-C1-ADC-21 (DAR4)
B7H3-C1-ADC-21(DAR4) payload
Undisclosed
B7H3-C1-ADC-21(DAR4) linker
[1]
B7H3-ADC-21 (DAR6)
B7H3-ADC-21(DAR6) payload
Undisclosed
B7H3-ADC-21(DAR6) linker
[1]
ADC Info ADC Name Payload Target Linker Ref
ChAb11-CZ
chAb11-CZ payload
Undisclosed
chAb11-CZ linker
[16]
ADC Info ADC Name Payload Target Linker Ref
ChAb13-CZ
chAb13-CZ payload
Undisclosed
chAb13-CZ linker
[16]
ADC Info ADC Name Payload Target Linker Ref
ChAb14-CZ
chAb14-CZ payload
Undisclosed
chAb14-CZ linker
[16]
ADC Info ADC Name Payload Target Linker Ref
ChAb16-CZ
chAb16-CZ payload
Undisclosed
chAb16-CZ linker
[16]
ADC Info ADC Name Payload Target Linker Ref
ChAb18-CZ
chAb18-CZ payload
Undisclosed
chAb18-CZ linker
[16]
chAb2 (chimra IgG1)
ADC Info ADC Name Payload Target Linker Ref
ChAb2-CZ
chAb2-CZ payload
Undisclosed
chAb2-CZ linker
[16]
ADC Info ADC Name Payload Target Linker Ref
ChAb3-CZ
chAb3-CZ payload
Undisclosed
chAb3-CZ linker
[16]
ADC Info ADC Name Payload Target Linker Ref
ChAb4-CZ
chAb4-CZ payload
Undisclosed
chAb4-CZ linker
[16]
ADC Info ADC Name Payload Target Linker Ref
ChAb6-CZ
chAb6-CZ payload
Undisclosed
chAb6-CZ linker
[16]
ADC Info ADC Name Payload Target Linker Ref
ChmAb-A B7-H3-ADC
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
[17]
ADC Info ADC Name Payload Target Linker Ref
ChmAb-B B7-H3-ADC
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
[17]
ADC Info ADC Name Payload Target Linker Ref
ChmAb-C B7-H3-ADC
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
[17]
ADC Info ADC Name Payload Target Linker Ref
ChmAb-D B7-H3-ADC
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
[17]
Enoblituzumab
ADC Info ADC Name Payload Target Linker Ref
Enoblituzumab-ADC-24-1
Enoblituzumab-ADC-24-1 payload
Undisclosed
Enoblituzumab-ADC-24-1 linker
[2]
Enoblituzumab-ADC-24-2
Enoblituzumab-ADC-24-2 payload
Undisclosed
Enoblituzumab-ADC-24-2 linker
[2]
Enoblituzumab-ADC-24-3
Enoblituzumab-ADC-24-3 payload
Undisclosed
Enoblituzumab-ADC-24-3 linker
[2]
Enoblituzumab-ADC-24-4
Enoblituzumab-ADC-24-4 payload
Undisclosed
Enoblituzumab-ADC-24-4 linker
[2]
Enoblituzumab-ADC-24-5
Enoblituzumab-ADC-24-5 payload
Undisclosed
Enoblituzumab-ADC-24-5 linker
[2]
Enoblituzumab-ADC-24-6
Enoblituzumab-ADC-24-6 payload
Undisclosed
Enoblituzumab-ADC-24-6 linker
[2]
Enoblituzumab-ADC-24-7
Enoblituzumab-ADC-24-7 payload
Undisclosed
Enoblituzumab-ADC-24-7 linker
[2]
Enoblituzumab-ADC-24-8
Enoblituzumab-ADC-24-8 payload
Undisclosed
Enoblituzumab-ADC-24-8 linker
[2]
Enoblituzumab-ADC-24-9
Enoblituzumab-ADC-24-9 payload
Undisclosed
Enoblituzumab-ADC-24-9 linker
[2]
Enoblituzumab-ADC-24-10
Enoblituzumab-ADC-24-10 payload
Undisclosed
Enoblituzumab-ADC-24-10 linker
[2]
Enoblituzumab-ADC-24-11
Enoblituzumab-ADC-24-11 payload
Undisclosed
Enoblituzumab-ADC-24-11 linker
[2]
Enoblituzumab-ADC-24-12
Enoblituzumab-ADC-24-12 payload
Undisclosed
Enoblituzumab-ADC-24-12 linker
[2]
Enoblituzumab-ADC-24-13
Enoblituzumab-ADC-24-13 payload
Undisclosed
Enoblituzumab-ADC-24-13 linker
[2]
Enoblituzumab-ADC-Tb1-1
Enoblituzumab-ADC-Tb1-1 payload
Undisclosed
Enoblituzumab-ADC-Tb1-1 linker
[1]
Enoblituzumab-ADC-Tb1-2
Enoblituzumab-ADC-Tb1-2 payload
Undisclosed
Enoblituzumab-ADC-Tb1-2 linker
[1]
Enoblituzumab-ADC-Tb1-3
Enoblituzumab-ADC-Tb1-3 payload
Undisclosed
Enoblituzumab-ADC-Tb1-3 linker
[1]
Enoblituzumab-ADC-Tb1-4
Enoblituzumab-ADC-Tb1-4 payload
Undisclosed
Enoblituzumab-ADC-Tb1-4 linker
[1]
Enoblituzumab-ADC-Tb1-5
Enoblituzumab-ADC-Tb1-5 payload
Undisclosed
Enoblituzumab-ADC-Tb1-5 linker
[1]
Enoblituzumab-ADC-Tb1-6
Enoblituzumab-ADC-Tb1-6 payload
Undisclosed
Enoblituzumab-ADC-Tb1-6 linker
[1]
Enoblituzumab-ADC-Tb1-7
Enoblituzumab-ADC-Tb1-7 payload
Undisclosed
Enoblituzumab-ADC-Tb1-7 linker
[1]
Enoblituzumab-ADC-Tb1-8
Enoblituzumab-ADC-Tb1-8 payload
Undisclosed
Enoblituzumab-ADC-Tb1-8 linker
[1]
Enoblituzumab-ADC-Tb1-9
Enoblituzumab-ADC-Tb1-9 payload
Undisclosed
Enoblituzumab-ADC-Tb1-9 linker
[1]
Enoblituzumab-ADC-Tb1-10
Enoblituzumab-ADC-Tb1-10 payload
Undisclosed
Enoblituzumab-ADC-Tb1-10 linker
[1]
Enoblituzumab-ADC-Tb1-11
Enoblituzumab-ADC-Tb1-11 payload
Undisclosed
Enoblituzumab-ADC-Tb1-11 linker
[1]
Enoblituzumab-ADC-Tb1-12
Enoblituzumab-ADC-Tb1-12 payload
Undisclosed
Enoblituzumab-ADC-Tb1-12 linker
[1]
Enoblituzumab-ADC-Tb1-13
Enoblituzumab-ADC-Tb1-13 payload
Undisclosed
Enoblituzumab-ADC-Tb1-13 linker
[1]
Enoblituzumab-ADC-Tb1-14
Enoblituzumab-ADC-Tb1-14 payload
Undisclosed
Enoblituzumab-ADC-Tb1-14 linker
[1]
Enoblituzumab-ADC-Tb1-15
Enoblituzumab-ADC-Tb1-15 payload
Undisclosed
Enoblituzumab-ADC-Tb1-15 linker
[1]
Enoblituzumab-ADC-Tb1-16
Enoblituzumab-ADC-Tb1-16 payload
Undisclosed
Enoblituzumab-ADC-Tb1-16 linker
[1]
Enoblituzumab-ADC-Tb1-17
Enoblituzumab-ADC-Tb1-17 payload
Undisclosed
Enoblituzumab-ADC-Tb1-17 linker
[1]
Enoblituzumab-ADC-Tb1-18
Enoblituzumab-ADC-Tb1-18 payload
Undisclosed
Enoblituzumab-ADC-Tb1-18 linker
[1]
Enoblituzumab-ADC-Tb1-19
Enoblituzumab-ADC-Tb1-19 payload
Undisclosed
Enoblituzumab-ADC-Tb1-19 linker
[1]
Enoblituzumab-ADC-Tb1-20
Enoblituzumab-ADC-Tb1-20 payload
Undisclosed
Enoblituzumab-ADC-Tb1-20 linker
[1]
Enoblituzumab-ADC-Tb1-21
Enoblituzumab-ADC-Tb1-21 payload
Undisclosed
Enoblituzumab-ADC-Tb1-21 linker
[1]
Enoblituzumab-ADC-Tb1-22
Enoblituzumab-ADC-Tb1-22 payload
Undisclosed
Enoblituzumab-ADC-Tb1-22 linker
[1]
Enoblituzumab-ADC-Tb1-23
Enoblituzumab-ADC-Tb1-23 payload
Undisclosed
Enoblituzumab-ADC-Tb1-23 linker
[1]
Enoblituzumab-ADC-Tb1-24
Enoblituzumab-ADC-Tb1-24 payload
Undisclosed
Enoblituzumab-ADC-Tb1-24 linker
[1]
Enoblituzumab-ADC-Tb1-25
Enoblituzumab-ADC-Tb1-25 payload
Undisclosed
Enoblituzumab-ADC-Tb1-25 linker
[1]
Enoblituzumab-ADC-Tb1-26
Enoblituzumab-ADC-Tb1-26 payload
Undisclosed
Enoblituzumab-ADC-Tb1-26 linker
[1]
ADC Info ADC Name Payload Target Linker Ref
HmAb-C-DUBA
seco-DUBA
Human Deoxyribonucleic acid (hDNA)
Mal-PEG2-Val-Cit-PABA-Cyclization Spacer
[17]
Hu276 mAb
ADC Info ADC Name Payload Target Linker Ref
CD276 mAb-MMAF
Monomethyl auristatin F
Microtubule (MT)
DBM linker
[18]
CD276 mAb-IMQ
imiquimod
Toll-like receptor 7 (TLR7); Toll-like receptor 8 (TLR8)
Phosphine-azide
[18]
CD276 mAb-MMAF/IMQ
Monomethyl auristatin F; imiquimod
Undisclosed
DBM linker
[18]
ADC Info ADC Name Payload Target Linker Ref
HuAb13v1-CZ
huAb13v1-CZ payload
Undisclosed
huAb13v1-CZ linker
[16]
HuAb13v1-TX
huAb13v1-TX payload
Undisclosed
huAb13v1-TX linker
[16]
HuAb13v1-TV
huAb13v1-TV payload
Undisclosed
huAb13v1-TV linker
[16]
HuAb13v1-AAA
huAb13v1-AAA payload
Undisclosed
huAb13v1-AAA linker
[16]
HuAb13v1-AAD
huAb13v1-AAD payload
Undisclosed
huAb13v1-AAD linker
[16]
HuAb13v1-WD
huAb13v1-WD payload
Undisclosed
huAb13v1-WD linker
[16]
HuAb13v1-LB
huAb13v1-LB payload
Undisclosed
huAb13v1-LB linker
[16]
HuAb13v1-ZT
huAb13v1-ZT payload
Undisclosed
huAb13v1-ZT linker
[16]
HuAb13v1-ZZ
huAb13v1-ZZ payload
Undisclosed
huAb13v1-ZZ linker
[16]
HuAb13v1-XW
huAb13v1-XW payload
Undisclosed
huAb13v1-XW linker
[16]
HuAb13v1-SE
huAb13v1-SE payload
Undisclosed
huAb13v1-SE linker
[16]
HuAb13v1-SR
huAb13v1-SR payload
Undisclosed
huAb13v1-SR linker
[16]
HuAb13v1-YG
huAb13v1-YG payload
Undisclosed
huAb13v1-YG linker
[16]
HuAb13v1-KZ
huAb13v1-KZ payload
Undisclosed
huAb13v1-KZ linker
[16]
HuAb13v1-WD E2
huAb13v1-WD E2 payload
Undisclosed
huAb13v1-WD E2 linker
[16]
HuAb13v1-TX E2
huAb13v1-TX E2 payload
Undisclosed
huAb13v1-TX E2 linker
[16]
ADC Info ADC Name Payload Target Linker Ref
HuAb18v1-CZ
huAb18v1-CZ payload
Undisclosed
huAb18v1-CZ linker
[16]
huAb18v10
ADC Info ADC Name Payload Target Linker Ref
HuAb18v10-CZ
huAb18v10-CZ payload
Undisclosed
huAb18v10-CZ linker
[16]
ADC Info ADC Name Payload Target Linker Ref
HuAb18v2-CZ
huAb18v2-CZ payload
Undisclosed
huAb18v2-CZ linker
[16]
ADC Info ADC Name Payload Target Linker Ref
HuAb18v3-CZ
huAb18v3-CZ payload
Undisclosed
huAb18v3-CZ linker
[16]
ADC Info ADC Name Payload Target Linker Ref
HuAb18v4-CZ
huAb18v4-CZ payload
Undisclosed
huAb18v4-CZ linker
[16]
ADC Info ADC Name Payload Target Linker Ref
HuAb18v5-CZ
huAb18v5-CZ payload
Undisclosed
huAb18v5-CZ linker
[16]
ADC Info ADC Name Payload Target Linker Ref
HuAb18v6-CZ
huAb18v6-CZ payload
Undisclosed
huAb18v6-CZ linker
[16]
ADC Info ADC Name Payload Target Linker Ref
HuAb18v7-CZ
huAb18v7-CZ payload
Undisclosed
huAb18v7-CZ linker
[16]
ADC Info ADC Name Payload Target Linker Ref
HuAb18v8-CZ
huAb18v8-CZ payload
Undisclosed
huAb18v8-CZ linker
[16]
ADC Info ADC Name Payload Target Linker Ref
HuAb18v9-CZ
huAb18v9-CZ payload
Undisclosed
huAb18v9-CZ linker
[16]
ADC Info ADC Name Payload Target Linker Ref
HuAb3v1-CZ
huAb3v1-CZ payload
Undisclosed
huAb3v1-CZ linker
[16]
ADC Info ADC Name Payload Target Linker Ref
HuAb3v2-CZ
huAb3v2-CZ payload
Undisclosed
huAb3v2-CZ linker
[16]
huAb3v2.2
ADC Info ADC Name Payload Target Linker Ref
HuAb3v2.2-CZ
huAb3v2.2-CZ payload
Undisclosed
huAb3v2.2-CZ linker
[16]
huAb3v2.3
ADC Info ADC Name Payload Target Linker Ref
HuAb3v2.3-CZ
huAb3v2.3-CZ payload
Undisclosed
huAb3v2.3-CZ linker
[16]
huAb3v2.5
ADC Info ADC Name Payload Target Linker Ref
HuAb3v2.5-CZ
huAb3v2.5-CZ payload
Undisclosed
huAb3v2.5-CZ linker
[16]
HuAb3v2.5-TX
huAb3v2.5-TX payload
Undisclosed
huAb3v2.5-TX linker
[16]
HuAb3v2.5-TV
huAb3v2.5-TV payload
Undisclosed
huAb3v2.5-TV linker
[16]
HuAb3v2.5-YY
huAb3v2.5-YY payload
Undisclosed
huAb3v2.5-YY linker
[16]
HuAb3v2.5-AAA
huAb3v2.5-AAA payload
Undisclosed
huAb3v2.5-AAA linker
[16]
HuAb3v2.5-AAD
huAb3v2.5-AAD payload
Undisclosed
huAb3v2.5-AAD linker
[16]
HuAb3v2.5-WD
huAb3v2.5-WD payload
Undisclosed
huAb3v2.5-WD linker
[16]
HuAb3v2.5-LB
huAb3v2.5-LB payload
Undisclosed
huAb3v2.5-LB linker
[16]
HuAb3v2.5-ZT
huAb3v2.5-ZT payload
Undisclosed
huAb3v2.5-ZT linker
[16]
HuAb3v2.5-ZZ
huAb3v2.5-ZZ payload
Undisclosed
huAb3v2.5-ZZ linker
[16]
HuAb3v2.5-XW
huAb3v2.5-XW payload
Undisclosed
huAb3v2.5-XW linker
[16]
HuAb3v2.5-SE
huAb3v2.5-SE payload
Undisclosed
huAb3v2.5-SE linker
[16]
HuAb3v2.5-SR
huAb3v2.5-SR payload
Undisclosed
huAb3v2.5-SR linker
[16]
HuAb3v2.5-YG
huAb3v2.5-YG payload
Undisclosed
huAb3v2.5-YG linker
[16]
HuAb3v2.5-KZ
huAb3v2.5-KZ payload
Undisclosed
huAb3v2.5-KZ linker
[16]
huAb3v2.6
ADC Info ADC Name Payload Target Linker Ref
HuAb3v2.6-CZ
huAb3v2.6-CZ payload
Undisclosed
huAb3v2.6-CZ linker
[16]
HuAb3v2.6-TX
huAb3v2.6-TX payload
Undisclosed
huAb3v2.6-TX linker
[16]
HuAb3v2.6-TV
huAb3v2.6-TV payload
Undisclosed
huAb3v2.6-TV linker
[16]
HuAb3v2.6-YY
huAb3v2.6-YY payload
Undisclosed
huAb3v2.6-YY linker
[16]
HuAb3v2.6-AAA
huAb3v2.6-AAA payload
Undisclosed
huAb3v2.6-AAA linker
[16]
HuAb3v2.6-AAD
huAb3v2.6-AAD payload
Undisclosed
huAb3v2.6-AAD linker
[16]
HuAb3v2.6-WD
huAb3v2.6-WD payload
Undisclosed
huAb3v2.6-WD linker
[16]
HuAb3v2.6-LB
huAb3v2.6-LB payload
Undisclosed
huAb3v2.6-LB linker
[16]
HuAb3v2.6-ZT
huAb3v2.6-ZT payload
Undisclosed
huAb3v2.6-ZT linker
[16]
HuAb3v2.6-ZZ
huAb3v2.6-ZZ payload
Undisclosed
huAb3v2.6-ZZ linker
[16]
HuAb3v2.6-XW
huAb3v2.6-XW payload
Undisclosed
huAb3v2.6-XW linker
[16]
HuAb3v2.6-SE
huAb3v2.6-SE payload
Undisclosed
huAb3v2.6-SE linker
[16]
HuAb3v2.6-SR
huAb3v2.6-SR payload
Undisclosed
huAb3v2.6-SR linker
[16]
HuAb3v2.6-YG
huAb3v2.6-YG payload
Undisclosed
huAb3v2.6-YG linker
[16]
HuAb3v2.6-KZ
huAb3v2.6-KZ payload
Undisclosed
huAb3v2.6-KZ linker
[16]
huAb3v2.8
ADC Info ADC Name Payload Target Linker Ref
HuAb3v2.8-CZ
huAb3v2.8-CZ payload
Undisclosed
huAb3v2.8-CZ linker
[16]
huAb3v2.9
ADC Info ADC Name Payload Target Linker Ref
HuAb3v2.9-CZ
huAb3v2.9-CZ payload
Undisclosed
huAb3v2.9-CZ linker
[16]
HuAb3v2.9-TX
huAb3v2.9-TX payload
Undisclosed
huAb3v2.9-TX linker
[16]
ADC Info ADC Name Payload Target Linker Ref
HuAb3v3-CZ
huAb3v3-CZ payload
Undisclosed
huAb3v3-CZ linker
[16]
ADC Info ADC Name Payload Target Linker Ref
HuAb3v4-CZ
huAb3v4-CZ payload
Undisclosed
huAb3v4-CZ linker
[16]
ADC Info ADC Name Payload Target Linker Ref
HuAb3v5-CZ
huAb3v5-CZ payload
Undisclosed
huAb3v5-CZ linker
[16]
ADC Info ADC Name Payload Target Linker Ref
HuAb3v6-CZ
huAb3v6-CZ payload
Undisclosed
huAb3v6-CZ linker
[16]
Ifinatamab
ADC Info ADC Name Payload Target Linker Ref
ZA202500415A-ADC Example 4
NMT inhibitor 1
N-Myristoyltransferase (NMT)
ZA202500415A-ADC-Example-1-Linker
[19]
SG11202408662TA ADC-C1
DX-8951 derivative (DXd)
DNA topoisomerase 1 (TOP1)
Mc-Gly-Gly-Phe-Gly
[20]
SG11202408662TA ADC-C2
Undisclosed
Undisclosed
Undisclosed
[20]
SG11202408662TA ADC-C3
Undisclosed
Undisclosed
Undisclosed
[20]
SG11202408662TA ADC-C4
Undisclosed
Undisclosed
Undisclosed
[20]
SG11202408662TA ADC-C5
Undisclosed
Undisclosed
Undisclosed
[20]
SG11202408662TA ADC-C6
Undisclosed
Undisclosed
Undisclosed
[20]
SG11202408662TA ADC-C7
Undisclosed
Undisclosed
Undisclosed
[20]
SG11202408662TA ADC-C8
Undisclosed
Undisclosed
Undisclosed
[20]
SG11202408662TA ADC-C9
Undisclosed
Undisclosed
Undisclosed
[20]
SG11202408662TA ADC-C10
Undisclosed
Undisclosed
Undisclosed
[20]
SG11202408662TA ADC-C11
Undisclosed
Undisclosed
Undisclosed
[20]
SG11202408662TA ADC-C12
Undisclosed
Undisclosed
Undisclosed
[20]
SG11202408662TA ADC-C13
Undisclosed
Undisclosed
Undisclosed
[20]
SG11202408662TA ADC-C14
Undisclosed
Undisclosed
Undisclosed
[20]
WO2024165045A1 ADC-B
Undisclosed
Undisclosed
Undisclosed
[21]
WO2024165045A1 ADC-4
Undisclosed
Undisclosed
Undisclosed
[21]
WO2024165045A1 ADC-5
Undisclosed
Undisclosed
Undisclosed
[21]
WO2024165045A1 ADC-6
Undisclosed
Undisclosed
Undisclosed
[21]
WO2024165045A1 ADC-7
Undisclosed
Undisclosed
Undisclosed
[21]
WO2024165045A1 ADC-8
Undisclosed
Undisclosed
Undisclosed
[21]
WO2024165045A1 ADC-9
Undisclosed
Undisclosed
Undisclosed
[21]
WO2024165045A1 ADC-10
Undisclosed
Undisclosed
Undisclosed
[21]
WO2024165045A1 ADC-11
Undisclosed
Undisclosed
Undisclosed
[21]
WO2024165045A1 ADC-12
Undisclosed
Undisclosed
Undisclosed
[21]
WO2024165045A1 ADC-13
Undisclosed
Undisclosed
Undisclosed
[21]
WO2024165045A1 ADC-14
Undisclosed
Undisclosed
Undisclosed
[21]
WO2024165045A1 ADC-16
Undisclosed
Undisclosed
Undisclosed
[21]
CN119317630A ADC-C1
DX-8951 derivative (DXd)
DNA topoisomerase 1 (TOP1)
Mc-Gly-Gly-Phe-Gly
[22]
CN119317630A ADC-C2
DX-8951 derivative (DXd)
DNA topoisomerase 1 (TOP1)
Mc-Gly-Gly-Phe-Gly
[22]
CN119317630A ADC-C3
DX-8951 derivative (DXd)
DNA topoisomerase 1 (TOP1)
CN119317630A ADC-C3 Linker
[22]
CN119317630A ADC-C4
DX-8951 derivative (DXd)
DNA topoisomerase 1 (TOP1)
CN119317630A ADC-C3 Linker
[22]
CN119317630A ADC-C5
DX-8951 derivative (DXd)
DNA topoisomerase 1 (TOP1)
CN119317630A ADC-C5 Linker
[22]
CN119317630A ADC-C6
DX-8951 derivative (DXd)
DNA topoisomerase 1 (TOP1)
CN119317630A ADC-C5 Linker
[22]
CN119317630A ADC-C7
DX-8951 derivative (DXd)
DNA topoisomerase 1 (TOP1)
CN119317630A ADC-C7 Linker
[22]
CN119317630A ADC-C8
DX-8951 derivative (DXd)
DNA topoisomerase 1 (TOP1)
CN119317630A ADC-C8 Linker
[22]
CN119317630A ADC-C9
DX-8951 derivative (DXd)
DNA topoisomerase 1 (TOP1)
CN119317630A ADC-C9 Linker
[22]
CN119317630A ADC-C10
DX-8951 derivative (DXd)
DNA topoisomerase 1 (TOP1)
CN119317630A ADC-C10 Linker
[22]
CN119317630A ADC-C11
DX-8951 derivative (DXd)
DNA topoisomerase 1 (TOP1)
CN119317630A ADC-C11 Linker
[22]
CN119317630A ADC-C12
DX-8951 derivative (DXd)
DNA topoisomerase 1 (TOP1)
CN119317630A ADC-C12 Linker
[22]
CN119317630A ADC-C13
DX-8951 derivative (DXd)
DNA topoisomerase 1 (TOP1)
CN119317630A ADC-C13 Linker
[22]
CN119317630A ADC-C14
DX-8951 derivative (DXd)
DNA topoisomerase 1 (TOP1)
CN119317630A ADC-C14 Linker
[22]
Mirzotamab
ADC Info ADC Name Payload Target Linker Ref
Mirzotamab-ADC-Tb1-1
Mirzotamab-ADC-Tb1-1 payload
Undisclosed
Mirzotamab-ADC-Tb1-1 linker
[1]
Mirzotamab-ADC-Tb1-2
Mirzotamab-ADC-Tb1-2 payload
Undisclosed
Mirzotamab-ADC-Tb1-2 linker
[1]
Mirzotamab-ADC-Tb1-3
Mirzotamab-ADC-Tb1-3 payload
Undisclosed
Mirzotamab-ADC-Tb1-3 linker
[1]
Mirzotamab-ADC-Tb1-4
Mirzotamab-ADC-Tb1-4 payload
Undisclosed
Mirzotamab-ADC-Tb1-4 linker
[1]
Mirzotamab-ADC-Tb1-5
Mirzotamab-ADC-Tb1-5 payload
Undisclosed
Mirzotamab-ADC-Tb1-5 linker
[1]
Mirzotamab-ADC-Tb1-6
Mirzotamab-ADC-Tb1-6 payload
Undisclosed
Mirzotamab-ADC-Tb1-6 linker
[1]
Mirzotamab-ADC-Tb1-7
Mirzotamab-ADC-Tb1-7 payload
Undisclosed
Mirzotamab-ADC-Tb1-7 linker
[1]
Mirzotamab-ADC-Tb1-8
Mirzotamab-ADC-Tb1-8 payload
Undisclosed
Mirzotamab-ADC-Tb1-8 linker
[1]
Mirzotamab-ADC-Tb1-9
Mirzotamab-ADC-Tb1-9 payload
Undisclosed
Mirzotamab-ADC-Tb1-9 linker
[1]
Mirzotamab-ADC-Tb1-10
Mirzotamab-ADC-Tb1-10 payload
Undisclosed
Mirzotamab-ADC-Tb1-10 linker
[1]
Mirzotamab-ADC-Tb1-11
Mirzotamab-ADC-Tb1-11 payload
Undisclosed
Mirzotamab-ADC-Tb1-11 linker
[1]
Mirzotamab-ADC-Tb1-12
Mirzotamab-ADC-Tb1-12 payload
Undisclosed
Mirzotamab-ADC-Tb1-12 linker
[1]
Mirzotamab-ADC-Tb1-13
Mirzotamab-ADC-Tb1-13 payload
Undisclosed
Mirzotamab-ADC-Tb1-13 linker
[1]
Mirzotamab-ADC-Tb1-14
Mirzotamab-ADC-Tb1-14 payload
Undisclosed
Mirzotamab-ADC-Tb1-14 linker
[1]
Mirzotamab-ADC-Tb1-15
Mirzotamab-ADC-Tb1-15 payload
Undisclosed
Mirzotamab-ADC-Tb1-15 linker
[1]
Mirzotamab-ADC-Tb1-16
Mirzotamab-ADC-Tb1-16 payload
Undisclosed
Mirzotamab-ADC-Tb1-16 linker
[1]
Mirzotamab-ADC-Tb1-17
Mirzotamab-ADC-Tb1-17 payload
Undisclosed
Mirzotamab-ADC-Tb1-17 linker
[1]
Mirzotamab-ADC-Tb1-18
Mirzotamab-ADC-Tb1-18 payload
Undisclosed
Mirzotamab-ADC-Tb1-18 linker
[1]
Mirzotamab-ADC-Tb1-19
Mirzotamab-ADC-Tb1-19 payload
Undisclosed
Mirzotamab-ADC-Tb1-19 linker
[1]
Mirzotamab-ADC-Tb1-20
Mirzotamab-ADC-Tb1-20 payload
Undisclosed
Mirzotamab-ADC-Tb1-20 linker
[1]
Mirzotamab-ADC-Tb1-21
Mirzotamab-ADC-Tb1-21 payload
Undisclosed
Mirzotamab-ADC-Tb1-21 linker
[1]
Mirzotamab-ADC-Tb1-22
Mirzotamab-ADC-Tb1-22 payload
Undisclosed
Mirzotamab-ADC-Tb1-22 linker
[1]
Mirzotamab-ADC-Tb1-23
Mirzotamab-ADC-Tb1-23 payload
Undisclosed
Mirzotamab-ADC-Tb1-23 linker
[1]
Mirzotamab-ADC-Tb1-24
Mirzotamab-ADC-Tb1-24 payload
Undisclosed
Mirzotamab-ADC-Tb1-24 linker
[1]
Mirzotamab-ADC-Tb1-25
Mirzotamab-ADC-Tb1-25 payload
Undisclosed
Mirzotamab-ADC-Tb1-25 linker
[1]
Mirzotamab-ADC-Tb1-26
Mirzotamab-ADC-Tb1-26 payload
Undisclosed
Mirzotamab-ADC-Tb1-26 linker
[1]
Non-pH-B7-H3 Ab
ADC Info ADC Name Payload Target Linker Ref
Non-pH-B7-H3 Ab-Dxd
DX-8951 derivative (DXd)
DNA topoisomerase 1 (TOP1)
Mc-Gly-Gly-Phe-Gly
[23]
Non-pH-B7-H3 Ab-MMAE
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
[23]
Omburtamab
ADC Info ADC Name Payload Target Linker Ref
Omburtamab-ADC-Tb1-1
Omburtamab-ADC-Tb1-1 payload
Undisclosed
Omburtamab-ADC-Tb1-1 linker
[1]
Omburtamab-ADC-Tb1-2
Omburtamab-ADC-Tb1-2 payload
Undisclosed
Omburtamab-ADC-Tb1-2 linker
[1]
Omburtamab-ADC-Tb1-3
Omburtamab-ADC-Tb1-3 payload
Undisclosed
Omburtamab-ADC-Tb1-3 linker
[1]
Omburtamab-ADC-Tb1-4
Omburtamab-ADC-Tb1-4 payload
Undisclosed
Omburtamab-ADC-Tb1-4 linker
[1]
Omburtamab-ADC-Tb1-5
Omburtamab-ADC-Tb1-5 payload
Undisclosed
Omburtamab-ADC-Tb1-5 linker
[1]
Omburtamab-ADC-Tb1-6
Omburtamab-ADC-Tb1-6 payload
Undisclosed
Omburtamab-ADC-Tb1-6 linker
[1]
Omburtamab-ADC-Tb1-7
Omburtamab-ADC-Tb1-7 payload
Undisclosed
Omburtamab-ADC-Tb1-7 linker
[1]
Omburtamab-ADC-Tb1-8
Omburtamab-ADC-Tb1-8 payload
Undisclosed
Omburtamab-ADC-Tb1-8 linker
[1]
Omburtamab-ADC-Tb1-9
Omburtamab-ADC-Tb1-9 payload
Undisclosed
Omburtamab-ADC-Tb1-9 linker
[1]
Omburtamab-ADC-Tb1-10
Omburtamab-ADC-Tb1-10 payload
Undisclosed
Omburtamab-ADC-Tb1-10 linker
[1]
Omburtamab-ADC-Tb1-11
Omburtamab-ADC-Tb1-11 payload
Undisclosed
Omburtamab-ADC-Tb1-11 linker
[1]
Omburtamab-ADC-Tb1-12
Omburtamab-ADC-Tb1-12 payload
Undisclosed
Omburtamab-ADC-Tb1-12 linker
[1]
Omburtamab-ADC-Tb1-13
Omburtamab-ADC-Tb1-13 payload
Undisclosed
Omburtamab-ADC-Tb1-13 linker
[1]
Omburtamab-ADC-Tb1-14
Omburtamab-ADC-Tb1-14 payload
Undisclosed
Omburtamab-ADC-Tb1-14 linker
[1]
Omburtamab-ADC-Tb1-15
Omburtamab-ADC-Tb1-15 payload
Undisclosed
Omburtamab-ADC-Tb1-15 linker
[1]
Omburtamab-ADC-Tb1-16
Omburtamab-ADC-Tb1-16 payload
Undisclosed
Omburtamab-ADC-Tb1-16 linker
[1]
Omburtamab-ADC-Tb1-17
Omburtamab-ADC-Tb1-17 payload
Undisclosed
Omburtamab-ADC-Tb1-17 linker
[1]
Omburtamab-ADC-Tb1-18
Omburtamab-ADC-Tb1-18 payload
Undisclosed
Omburtamab-ADC-Tb1-18 linker
[1]
Omburtamab-ADC-Tb1-19
Omburtamab-ADC-Tb1-19 payload
Undisclosed
Omburtamab-ADC-Tb1-19 linker
[1]
Omburtamab-ADC-Tb1-20
Omburtamab-ADC-Tb1-20 payload
Undisclosed
Omburtamab-ADC-Tb1-20 linker
[1]
Omburtamab-ADC-Tb1-21
Omburtamab-ADC-Tb1-21 payload
Undisclosed
Omburtamab-ADC-Tb1-21 linker
[1]
Omburtamab-ADC-Tb1-22
Omburtamab-ADC-Tb1-22 payload
Undisclosed
Omburtamab-ADC-Tb1-22 linker
[1]
Omburtamab-ADC-Tb1-23
Omburtamab-ADC-Tb1-23 payload
Undisclosed
Omburtamab-ADC-Tb1-23 linker
[1]
Omburtamab-ADC-Tb1-24
Omburtamab-ADC-Tb1-24 payload
Undisclosed
Omburtamab-ADC-Tb1-24 linker
[1]
Omburtamab-ADC-Tb1-25
Omburtamab-ADC-Tb1-25 payload
Undisclosed
Omburtamab-ADC-Tb1-25 linker
[1]
Omburtamab-ADC-Tb1-26
Omburtamab-ADC-Tb1-26 payload
Undisclosed
Omburtamab-ADC-Tb1-26 linker
[1]
pH-B7-H3 Ab
ADC Info ADC Name Payload Target Linker Ref
pH-B7-H3 Ab-Dxd
DX-8951 derivative (DXd)
DNA topoisomerase 1 (TOP1)
Mc-Gly-Gly-Phe-Gly
[23]
pH-B7-H3 Ab-MMAE
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
[23]
ADC Info ADC Name Payload Target Linker Ref
Anti-B7H3 APDC 3f
Kinesin spindle protein (KSP) inhibitor 3f
Kinesin-like protein KIF11 (KIF11)
Open-chain glycine maleimide
[24]
Anti-B7H3 APDC 3g
Kinesin spindle protein (KSP) inhibitor 3g
Kinesin-like protein KIF11 (KIF11)
Open-chain glycine maleimide
[24]
Undisclosed
ADC Info ADC Name Payload Target Linker Ref
IBI-129
Undisclosed
Undisclosed
Undisclosed
YBL-015
Undisclosed
Undisclosed
Undisclosed
[25]
64Cu-DOTAGA-alphaCD276 mAb
Undisclosed
Undisclosed
Undisclosed
[26]
B7-H3 ADC (Jiangsu hengrui)
Undisclosed
Undisclosed
Undisclosed
[27]
BVD-CD276
Undisclosed
Undisclosed
Undisclosed
[28]
B7H3-MMAE
Monomethyl auristatin E
Microtubule (MT)
Undisclosed
[29]
NV106
Panobinostat
Histone deacetylase 1 (HDAC1)
Undisclosed
[30]
NV104
Irinotecan
DNA topoisomerase 1 (TOP1)
Undisclosed
[30]
NV105
Temozolomide
Human Deoxyribonucleic acid (hDNA)
Undisclosed
[30]
undisclosed
ADC Info ADC Name Payload Target Linker Ref
ITC-6102RO
Benzodiazepine dimer derivative
Undisclosed
Maleimide-containing OHPAS linker
[31]
GLR1061
Undisclosed
Undisclosed
Undisclosed
[32]
antiB7H3 MF6
MF6
Undisclosed
Undisclosed
[33]
IL317340A-1
TW202500135A-1 payload
Undisclosed
Mc-Gly-Gly-Phe-Gly
[34]
IL317340A-2 1
TW202500135A-1 payload
Undisclosed
Mc-Gly-Gly-Phe-Gly
[34]
IL317340A-3
Undisclosed
Undisclosed
Mc-Gly-Gly-Phe-Gly
[34]
IL317340A-4
IL317340A-4payload
Undisclosed
Mc-Gly-Gly-Phe-Gly
[34]
IL317340A-5
IL317340A-5payload
Undisclosed
Mc-Gly-Gly-Phe-Gly
[34]
IL317340A-6
IL317340A-6payload
Undisclosed
Mc-Gly-Gly-Phe-Gly
[34]
IL317340A-7
IL317340A-7payload
Undisclosed
Mc-Gly-Gly-Phe-Gly
[34]
IL317340A-8
Topo1 inhibitor F
DNA topoisomerase I (TOP1)
Mc-Gly-Gly-Phe-Gly
[34]
IL317340A-9
IL317340A-9payload
Undisclosed
Mc-Gly-Gly-Phe-Gly
[34]
IL317340A-10
IL317340A-10payload
Undisclosed
Mc-Gly-Gly-Phe-Gly
[34]
IL317340A-11
Undisclosed
Undisclosed
Mc-Gly-Gly-Phe-Gly
[34]
IL317340A-12
Undisclosed
Undisclosed
Mc-Gly-Gly-Phe-Gly
[34]
IL317340A-13
TW202500135A-1 payload
Undisclosed
Mc-Gly-Gly-Phe-Gly
[34]
IL317340A-14
TW202500135A-1 payload
Undisclosed
Mc-Gly-Gly-Phe-Gly
[34]
Production of the antibody-drug conjugate (4)
undisclosed
Undisclosed
Undisclosed
[35]
References
Ref 1 Bioactive substance conjugate, preparation method therefor and use thereof; 2022-08-18.
Ref 2 Ligand-drug conjugate of exatecan analogue, preparation method therefor and application thereof; 2020-04-02.
Ref 3 Design, Synthesis, and Evaluation of Camptothecin-Based Antibody-Drug Conjugates with High Hydrophilicity and Structural Stability
Ref 4 Anti-b7h3 antibody-drug conjugate and use thereof
Ref 5 Multi-payload antibody-drug conjugates and their preparation methods and uses
Ref 6 A CD276-Targeted Antibody-Drug Conjugate to Treat Non-Small Lung Cancer (NSCLC)
Ref 7 Anti-b7h3 antibody-exatecan analog conjugate and medicinal use thereof; 2020-04-02.
Ref 8 The B7-H3-Targeting Antibody-Drug Conjugate m276-SL-PBD Is Potently Effective Against Pediatric Cancer Preclinical Solid Tumor Models. Clin Cancer Res. 2021 May 15;27(10):2938-2946. doi: 10.1158/1078-0432.CCR-20-4221. Epub 2021 Feb 22.
Ref 9 A Novel NAMPT Inhibitor-Based Antibody-Drug Conjugate Payload Class for Cancer Therapy. Bioconjug Chem. 2022 Jun 15;33(6):1210-1221.
Ref 10 Novel B7-H3- binding molecule, its antibody drug conjugate and its application method.
Ref 11 Antibody-drug conjugates and uses thereof
Ref 12 Development of a MMAE-based antibody-drug conjugate targeting B7-H3 for glioblastoma
Ref 13 PanRAS inhibitor antibody-drug conjugates and methods of use thereof
Ref 14 Drug conjugates and uses thereof
Ref 15 Antibody-drug conjugates containing toxins with polar groups and uses thereof
Ref 16 Anti-b7-h3 antibodies and antibody drug conjugates; 2018-03-08.
Ref 17 Novel b7-h3 binding molecules, antibody drug conjugates thereof and methods of use thereof; 2017-10-19.
Ref 18 A Dual-Payload Antibody-Drug Conjugate Targeting CD276/B7-H3 Elicits Cytotoxicity and Immune Activation in Triple-Negative Breast Cancer
Ref 19 Antibody drug conjugate comprising NMT inhibitor and its use
Ref 20 Antibody drug conjugates
Ref 21 Self-stabilizing linker conjugates
Ref 22 Antibody-drug complexes
Ref 23 A next generation ADC: AR153, pH-dependent anti-B7H3 MMAE
Ref 24 Antibody-Prodrug Conjugates with KSP Inhibitors and Legumain-Mediated Metabolite Formation. Chemistry. 2019 Jun 21;25(35):8208-8213. doi: 10.1002/chem.201900441. Epub 2019 Apr 15.
Ref 25 Y-Biologics biotechnology company product pipeline
Ref 26 Introduction to basic information on ADC drug 64Cu-DOTAGA-alphaCD276 mAb (Provenance).
Ref 27 Introduction to basic information on ADC drug B7-H3 ADC (Jiangsu hengrui).
Ref 28 Biomed valley discoveries product pipeline
Ref 29 Anwita biosciences product pipeline
Ref 30 Nanovalent pharmaceuticals product pipeline
Ref 31 ITC-6102RO, a novel B7-H3 antibody-drug conjugate, exhibits potent therapeutic effects against B7-H3 expressing solid tumors
Ref 32 Preclinical characterization of GLR1061, a B7H3-targeted ADC with a novel DNA topoisomerase I inhibitor, demonstrated superior bystander effect to overcome tumor heterogeneity
Ref 33 Design and synthesis of the novel camptothecin analog MF-6 for application into site-specific antibody-drug conjugate
Ref 34 Anti-B7-H3 antibody-drug conjugates and uses thereof
Ref 35 Combination of antibody-drug conjugate with anti-SIRPα antibody